09 - Appareils et instruments scientifiques et électriques
Produits et services
(Based on Use) Laboratory equipment, namely, laboratory pipettes, pipette tips, microcentrifuge tubes, reload systems for pipette tips, reload systems for pipette tips consisting of pipette tip rack, rack base and snap cards, pipette tip racks, pipette tip rack bases, laboratory vessels for physical, chemical and biotechnical applications, reservoirs, reagent reservoirs, laboratory tubes, plates, assay plates, deep well plates, PCR plates, cell culture and storage plates; refill systems for pipette tips comprising containers housing one or more arrays of pipette tips dispensable from the containers to refill empty racks and storage boxes; racks and storage boxes for pipette tips, laboratory syringes and laboratory capillaries; containers and holders for racks and storage boxes for pipette tips; snap cards to be combined with pipette tip rack bases to for pipette tip racks; snap cards holding pipette tips; pipette accessories, namely, stands for pipettes and carousel stands for pipettes (Based on Intent to Use) Laboratory equipment, namely, laboratory syringes, laboratory capillaries, laboratory vials, vials for storing biological materials, centrifuge tubes, PCR-tubes, vials for the preservation of specimens; refill systems for laboratory syringes and laboratory capillaries comprising containers housing one or more arrays of laboratory syringes or laboratory capillaries dispensable from the containers to refill empty racks and storage boxes; containers and holders for racks and storage boxes for laboratory syringes and laboratory capillaries
09 - Appareils et instruments scientifiques et électriques
Produits et services
Equipment for scientific and laboratory purposes; pipette tips; containers for samples for scientific use or for laboratory use; vials for scientific use or for laboratory use; vials for storing biological materials; vials for the preservation of specimens; reaction tubes, tubes, and mini test tubes for scientific use or for laboratory use; centrifuge tubes; microcentrifuge tubes; polymerase chain reaction tubes; plates for scientific use or for laboratory use; polymerase chain reaction (PCR) plates; cell culture plates; storage plates for scientific use or for laboratory use; plates having multi-well arrays for scientific use or for laboratory use; parts and accessories for scientific and laboratory equipment.
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Pipette tips; Pipette tip racks; Racks and storage boxes for laboratory pipette tips, laboratory syringes, and laboratory capillaries; Laboratory syringes, namely, Disposable dispenser syringes for laboratory use; Laboratory capillaries, namely, Capillary tubes for samples for laboratory use, Capillary reagent tubes for laboratory use; Reload systems for pipette tips consisting of a pipette tip rack, rack base and snap cards; Refill systems for pipette tips, laboratory syringes, and laboratory capillaries comprising containers housing one or more arrays of pipette tips, laboratory syringes, or laboratory capillaries dispensable from the containers to refill empty racks and storage boxes; Snap cards, to be combined with pipette tip rack bases to form pipette tip racks; Snap cards holding pipette tips to be combined with pipette tip rack bases to form pipette tip racks; Laboratory vessels, namely, laboratory glassware, plastic storage tubes, sterile sampling bags, containers especially made for laboratory waste, filters for physical, chemical and biotechnical applications; Reservoirs, in particular reagent reservoirs; Laboratory tubes, in particular microcentrifuge tubes, centrifuge tubes, PCR-tubes; Laboratory vials, in particular vials for storing biological materials, vials for the preservation of specimens, Plates, in particular assay plates, deep well plates, PCR-plates, cell culture and storage plates
The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
C09B 23/10 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre pair de groupes CH
C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
C09B 23/06 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH trois groupes CH, p. ex. carbocyanines
C07D 209/70 - Systèmes cycliques contenant au moins trois cycles condensés en [b] ou en [c] contenant des carbocycles autres que des cycles à six chaînons
Provided in part herein are pipette tip rack assemblies having one or more of the following features: (i) having a plurality of pipette tip receptacle plates, each plate having an array of pipette tips, stacked upon one another supported by a rack base; (ii) each plate having one or more projections from the proximal or distal surface and, optionally, orifices that oppose the projections of the next plate in the stack, and (iii) the rack base having a proximal surface with one or more orifices or projections that oppose the projections or orifices of the plate in the stack. Also provided are methods of dispensing pipette tips from pipette tip rack assemblies and manufacturing pipette tip rack assembly components.
B65D 85/00 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers
G01N 1/28 - Préparation d'échantillons pour l'analyse
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
Provided herein is a pipette tip tray that includes a base and a connected pipette tip receptacle plate, where the base includes a plurality of axially-disposed base ribs disposed on two or more internal wall surfaces, the pipette receptacle plate includes a plurality of plate ribs disposed on the distal surface of the plate, and a portion of at least a subset of the plate ribs is in contact with at least a portion of an end of at least a subset of the base ribs.
B65D 85/30 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour objets particulièrement sensibles aux dommages par chocs ou compression
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 9/00 - Dispositifs de supportDispositifs de serrage
B65D 25/10 - Dispositifs pour placer les objets dans les réceptacles
B65D 43/16 - Couvercles ou chapeaux inamovibles s'ouvrant à charnières vers le haut ou vers le bas
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.
2O, where Fum—fumaric acid anion, Me—zinc, calcium or magnesium, n=0-8 or mixture of these. The B group can be B12, B6, B2, preferably, at least two of these. Preferably also including at least one amino acid from the following: glycine, L-glutamic acid and/or its salts, L-arginine and/or its salts, L-carnitine and/or its salts, asparagine and/or its salts. Preferably also succinic, citric or isocitric acid and/or their salts. Preferably also including other vitamins, fillers, ballast substances, flavors, colors, sugars, oils.
The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.
G01N 33/532 - Production de composés immunochimiques marqués
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
C09B 11/24 - Phtaléines contenant des groupes amine
C09B 57/00 - Autres colorants synthétiques de structure connue
C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
C09B 23/06 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH trois groupes CH, p. ex. carbocyanines
G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
Provided herein is a single-walled pipette tip rack comprising buttresses for use in automated systems, in some embodiments. Also provided herein is a partial single-walled pipette tip rack comprising posts.
Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
Provided in part herein are multiple-tube devices that contain a region of reduced wall thickness, which devices facilitate biological fluid processing and analysis. Also provided in part herein are methods of manufacturing and using such devices.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are pipette tip rack assemblies in which a plurality of pipette tip racks are contained within a transparent or translucent non-porous container. Also provided are methods for using and manufacturing pipette tip rack assemblies described herein.
B29C 45/00 - Moulage par injection, c.-à-d. en forçant un volume déterminé de matière à mouler par une buse d'injection dans un moule ferméAppareils à cet effet
B29C 51/04 - Thermoformage combiné avec un pré-étirage, p. ex. étirage biaxial
Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
Disclosed here are pipette tips (100) useful for receiving and dispensing liquids, which include a plurality of interior ribs (155) with beveled proximal surfaces (163) in a proximal region of the pipette tip.
Provided herein is a pipette tip tray that includes a base and a connected pipette tip receptacle plate, where the base includes a plurality of axially-disposed base ribs disposed on two or more internal wall surfaces, the pipette receptacle plate includes a plurality of plate ribs disposed on the distal surface of the plate, and a portion of at least a subset of the plate ribs is in contact with at least a portion of an end of at least a subset of the base ribs.
B65D 85/30 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour objets particulièrement sensibles aux dommages par chocs ou compression
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 9/00 - Dispositifs de supportDispositifs de serrage
B65D 25/10 - Dispositifs pour placer les objets dans les réceptacles
B65D 43/16 - Couvercles ou chapeaux inamovibles s'ouvrant à charnières vers le haut ou vers le bas
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Provided herein is a pipette tip tray that includes a base and a connected pipette tip receptacle plate, where the base includes a plurality of axially-disposed base ribs disposed on two or more internal wall surfaces, the pipette receptacle plate includes a plurality of plate ribs disposed on the distal surface of the plate, and a portion of at least a subset of the plate ribs is in contact with at least a portion of an end of at least a subset of the base ribs.
B01L 9/00 - Dispositifs de supportDispositifs de serrage
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
52.
Methods, compositions and kits for labeling of proteins
Provided herein are methods, compositions and kits for labeling of target proteins such as antibodies. The methods, compositions and kits are suited for labeling of such proteins that are mixed with other non-target molecules including BSA, gelatin, and other complex biological molecules.
Provided herein are cap and tube component embodiments that permit ergonomic engagement and disengagement. Also provided herein are assemblies thereof in which a cap is in sealing engagement with a tube. When engaged with a tube, a cap may be pivoted with respect to a point located on the interior rim of the tube opening by applying a relatively small force to the exterior surface of the cap. Pivoting the cap at this point on the tube can break the seal between the tube and cap and permit removal of the cap from the tube for manipulation of fluid in the tube.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Provided herein are anti-static pipette trays that reduce the amount of static charge accumulated on or in pipette tips and allow for discharge of any accumulated static charge.
B01L 9/00 - Dispositifs de supportDispositifs de serrage
B65D 25/10 - Dispositifs pour placer les objets dans les réceptacles
B65D 85/00 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers
B65D 85/20 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour objets incompressibles ou rigides en forme de baguette ou tubulaires
Provided in part herein are pipette tip rack assemblies having one or more of the following features: (i) having a plurality of pipette tip receptacle plates, each plate having an array of pipette tips, stacked upon one another supported by a rack base; (ii) each plate having one or more projections from the proximal or distal surface and, optionally, orifices that oppose the projections of the next plate in the stack, and (iii) the rack base having a proximal surface with one or more orifices or projections that oppose the projections or orifices of the plate in the stack. Also provided are methods of dispensing pipette tips from pipette tip rack assemblies and manufacturing pipette tip rack assembly components.
B65D 85/00 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers
G01N 1/28 - Préparation d'échantillons pour l'analyse
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
Provided in part herein are pipette tip rack assemblies having one or more of the following features: (i) having a plurality of pipette tip receptacle plates, each plate having an array of pipette tips, stacked upon one another supported by a rack base; (ii) each plate having one or more projections from the proximal or distal surface and, optionally, orifices that oppose the projections of the next plate in the stack, and (iii) the rack base having a proximal surface with one or more orifices or projections that oppose the projections or orifices of the plate in the stack. Also provided are methods of dispensing pipette tips from pipette tip rack assemblies and manufacturing pipette tip rack assembly components.
In some aspects, the disclosure provides compounds comprising nucleic acid modifying moieties, such as nucleic acid binding dyes comprising activatable groups. In some aspects, the disclosure provides nucleic acid probes comprising compounds of the disclosure, and methods of making the same. In some aspects, the disclosure provides methods of using compounds of the disclosure, such as methods of labeling and/or detecting non-viable organisms or non-viable cells, and methods of detecting contamination or infection.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C07D 513/02 - Composés hétérocycliques contenant dans le système condensé au moins un hétérocycle comportant des atomes d'azote et de soufre comme uniques hétéro-atomes du cycle, non prévus dans les groupes , ou dans lesquels le système condensé contient deux hétérocycles
The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
C09B 11/24 - Phtaléines contenant des groupes amine
C09B 57/00 - Autres colorants synthétiques de structure connue
C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
C09B 23/06 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH trois groupes CH, p. ex. carbocyanines
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
C07K 17/06 - Peptides immobilisés sur, ou dans, un support organique liés au support au moyen d'un agent de pontage
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
Provided herein are anti-static pipette trays that reduce the amount of static charge accumulated on or in pipette tips and allow for discharge of any accumulated static charge.
B65D 85/20 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour objets incompressibles ou rigides en forme de baguette ou tubulaires
The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
C07H 15/26 - Radicaux acycliques ou carbocycliques substitués par des hétérocycles
C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 491/147 - Systèmes condensés en ortho le système condensé contenant un cycle avec l'oxygène comme hétéro-atome du cycle et deux cycles avec l'azote comme hétéro-atome du cycle
C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
C07D 491/22 - Composés hétérocycliques contenant dans le système cyclique condensé, à la fois un ou plusieurs cycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle, et un ou plusieurs cycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus dans les groupes , , ou dans lesquels le système condensé contient au moins quatre hétérocycles
C07F 9/6558 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle contenant au moins deux hétérocycles différents ou différemment substitués ni condensés entre eux ni condensés avec un carbocycle commun ou un système carbocyclique commun
81.
CAP AND FLUID HANDLING TUBE COMPONENTS AND ASSEMBLIES
Provided herein are cap and tube component embodiments that permit ergonomic engagement and disengagement. Also provided herein are assemblies thereof in which a cap is in sealing engagement with a tube. When engaged with a tube, a cap may be pivoted with respect to a point located on the interior rim of the tube opening by applying a relatively small force to the exterior surface of the cap. Pivoting the cap at this point on the tube can break the seal between the tube and cap and permit removal of the cap from the tube for manipulation of fluid in the tube.
Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Provided are pipette tip trays for use in biotechnology applications. In certain embodiments, provided are pipette tip trays having one or more of the following features: (i) lacking an external hinge between the lid and the rack, and (ii) having snap plate fasteners configured to releasably secure a snap plate to a base.
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
Discussed herein are methods and devices for storing, handling, loading or dispensing of pipette tips. Some embodiments allow repetitive loading of an array of multiple pipette tips that are stored in a nested configuration.
B65D 85/62 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour objets empilésRéceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour agencements particuliers de groupes d'objets
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Provided in part herein are multiple-tube devices that contain a region of reduced wall thickness, which devices facilitate biological fluid processing and analysis. Also provided in part herein are methods of manufacturing and using such devices.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
92.
Enzyme substrate comprising a functional dye and associated technology and methods
Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
C12N 9/96 - Stabilisation d'une enzyme par formation d'un adduct ou d'une compositionFormation de conjugaisons d'enzymes
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
C07D 417/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
C07D 501/00 - Composés hétérocycliques contenant des systèmes cycliques thia-5 aza-1 bicyclo [4.2.0] octane, c.-à-d. des composés contenant un système cyclique de formule , p. ex. céphalosporinesCes systèmes cycliques étant ultérieurement condensés, p. ex. condensés en positions 2, 3 avec des hétérocycles contenant de l'oxygène, de l'azote ou du soufre
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
Discussed herein are methods and devices for storing, handling, loading or dispensing of pipette tips. Some embodiments allow repetitive loading of an array of multiple pipette tips that are stored in a nested configuration.
B65D 85/62 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour objets empilésRéceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour agencements particuliers de groupes d'objets
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
The present invention relates to fluorescent dyes. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. In one aspect, the invention provides a compound having a maximal fluorescence excitation wavelength, wherein the compound has a structure of Formula II:
− is a counterion, Y is a bridge unit permitting electron delocalization between F and Ψ, and F is a moiety having the structure:
The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
C07K 2/00 - Peptides à nombre indéterminé d'amino-acidesLeurs dérivés
C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
C07H 17/02 - Radicaux hétérocycliques contenant uniquement des atomes d'azote comme hétéro-atomes du cycle
C07H 21/00 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
C09B 11/24 - Phtaléines contenant des groupes amine
C09B 23/01 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique
C09B 23/06 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH trois groupes CH, p. ex. carbocyanines
C09B 57/00 - Autres colorants synthétiques de structure connue
The invention provides compounds, including fluorescent nucleic acid dyes, and methods for use including nucleic acid detection, nucleic acid amplification reactions, and high-resolution melt curve analysis. Further provided are kits, instruments and systems comprising compounds of the invention or adapted for use with compounds of the invention or other nucleic acid dyes.
C07D 417/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
C07D 413/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07C 53/18 - Acides acétiques halogénés contenant du fluor
C07D 209/20 - Radicaux substitués par des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile substitués en outre par des atomes d'azote, p. ex. tryptophane
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
Provided herein is a single-walled pipette tip rack comprising buttresses for use in automated systems, in some embodiments. Also provided herein is a partial single-walled pipette tip rack comprising posts.
Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
