09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory equipment, namely, laboratory pipettes, pipette
tips, microcentrifuge tubes, reload systems for pipette
tips, reload systems for pipette tips consisting of pipette
tip rack, rack base and snap cards, pipette tip racks,
pipette tip rack bases, laboratory vessels for physical,
chemical and biotechnical applications, reservoirs, reagent
reservoirs, laboratory tubes, plates, assay plates, deep
well plates, PCR plates, cell culture and storage plates;
refill systems for pipette tips comprising containers
housing one or more arrays of pipette tips dispensable from
the containers to refill empty racks and storage boxes;
racks and storage boxes for pipette tips, laboratory
syringes and laboratory capillaries; containers and holders
for racks and storage boxes for pipette tips; snap cards to
be combined with pipette tip rack bases to form pipette tip
racks; snap cards holding pipette tips; pipette accessories,
namely, stands for pipettes and carousel stands for
pipettes; laboratory equipment, namely, laboratory syringes,
laboratory capillaries, laboratory vials, vials for storing
biological materials, centrifuge tubes, PCR-tubes, vials for
the preservation of specimens; refill systems for laboratory
syringes and laboratory capillaries comprising containers
housing one or more arrays of laboratory syringes or
laboratory capillaries dispensable from the containers to
refill empty racks and storage boxes; containers and holders
for racks and storage boxes for laboratory syringes and
laboratory capillaries.
09 - Scientific and electric apparatus and instruments
Goods & Services
Equipment for scientific and laboratory purposes; pipette
tips; containers for samples for scientific use or for
laboratory use; vials for scientific use or for laboratory
use; vials for storing biological materials; vials for the
preservation of specimens; reaction tubes, tubes, and mini
test tubes for scientific use or for laboratory use;
centrifuge tubes; microcentrifuge tubes; polymerase chain
reaction tubes; plates for scientific use or for laboratory
use; polymerase chain reaction (PCR) plates; cell culture
plates; storage plates for scientific use or for laboratory
use; plates having multi-well arrays for scientific use or
for laboratory use; parts and accessories for scientific and
laboratory equipment.
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Laboratory equipment, namely, laboratory pipettes, pipette tips, microcentrifuge tubes, reload systems for pipette tips, reload systems for pipette tips consisting of pipette tip rack, rack base and snap cards, pipette tip racks, pipette tip rack bases, laboratory vessels for physical, chemical and biotechnical applications, reservoirs, reagent reservoirs, laboratory tubes, plates, assay plates, deep well plates, PCR plates, cell culture and storage plates; refill systems for pipette tips comprising containers housing one or more arrays of pipette tips dispensable from the containers to refill empty racks and storage boxes; racks and storage boxes for pipette tips, laboratory syringes and laboratory capillaries; containers and holders for racks and storage boxes for pipette tips; snap cards to be combined with pipette tip rack bases to form pipette tip racks; snap cards holding pipette tips; pipette accessories, namely, stands for pipettes and carousel stands for pipettes; laboratory equipment, namely, laboratory syringes, laboratory capillaries, laboratory vials, vials for storing biological materials, centrifuge tubes, PCR-tubes, vials for the preservation of specimens; refill systems for laboratory syringes and laboratory capillaries comprising containers housing one or more arrays of laboratory syringes or laboratory capillaries dispensable from the containers to refill empty racks and storage boxes; containers and holders for racks and storage boxes for laboratory syringes and laboratory capillaries.
09 - Scientific and electric apparatus and instruments
Goods & Services
(1) Equipment for scientific and laboratory purposes; pipette tips; containers for samples for scientific use or for laboratory use; vials for scientific use or for laboratory use; vials for storing biological materials; vials for the preservation of specimens; reaction tubes, tubes, and mini test tubes for scientific use or for laboratory use; centrifuge tubes; microcentrifuge tubes; polymerase chain reaction tubes; plates for scientific use or for laboratory use; polymerase chain reaction (PCR) plates; cell culture plates; storage plates for scientific use or for laboratory use; plates having multi-well arrays for scientific use or for laboratory use; parts and accessories for scientific and laboratory equipment.
09 - Scientific and electric apparatus and instruments
Goods & Services
(Based on use) Laboratory equipment, namely, laboratory pipettes, pipette tips, microcentrifuge tubes, reload systems for pipette tips, reload systems for pipette tips consisting of pipette tip rack, rack base and snap cards, pipette tip racks, pipette tip rack bases, laboratory vessels for physical, chemical and biotechnical applications, reservoirs, reagent reservoirs, laboratory tubes, plates, assay plates, deep well plates, PCR plates, cell culture and storage plates; refill systems for pipette tips comprising containers housing one or more arrays of pipette tips dispensable from the containers to refill empty racks and storage boxes; racks and storage boxes for laboratory pipette tips, laboratory syringes and laboratory capillaries; containers and holders specially adapted and designed for holding and storing laboratory pipette racks and laboratory pipette tip storage boxes; snap cards to be combined with laboratory pipette tip rack bases to form pipette tip racks; snap cards holding laboratory pipette tips to be combined with pipette tip rack bases to form pipette tip racks; laboratory pipette accessories, namely, stands for pipettes and carousel stands for pipettes (Based on Intent to Use) Laboratory equipment, namely, laboratory syringes, laboratory capillaries, laboratory vials, vials for storing biological materials, centrifuge tubes, PCR-tubes, vials for the preservation of specimens; refill systems for laboratory syringes and laboratory capillaries comprising containers housing one or more arrays of laboratory syringes or laboratory capillaries dispensable from the containers to refill empty racks and storage boxes; containers and holders specially adapted and designed for holding and storing laboratory syringe and laboratory capillary racks and laboratory syringe and laboratory capillary storage boxes
09 - Scientific and electric apparatus and instruments
Goods & Services
Equipment for scientific and laboratory purposes, namely, pipette tips and pipette racks for scientific use and laboratory use; containers for samples for scientific use and for laboratory use, namely, containers especially made for holding liquid reagents and biological materials; vials for scientific use and for laboratory use; Scientific research specimen collection devices in the nature of vials for storing biological materials, namely, DNA, RNA, proteins, cells, antibodies, buffers, small molecules, and cultures of blood, urine, saliva, tissue, and microbial samples; Scientific research specimen collection devices in the nature of vials for the preservation of DNA, RNA, proteins, cells, antibodies, buffers, small molecules, and cultures of blood, urine, saliva, tissue, and microbial samples; reaction test tubes, test tubes, and mini test tubes for scientific use and for laboratory use; centrifuge tubes for scientific and laboratory use; microcentrifuge tubes for scientific and laboratory use; polymerase chain reaction tubes; plates for scientific use and for laboratory use; polymerase chain reaction (PCR) plates for scientific use and for laboratory use; cell culture plates for scientific use and for laboratory use; storage plates for scientific use and for laboratory use; plates having multi-well arrays for scientific use and for laboratory use
HADASIT MEDICAL RESEARCH SERVICS AND DEVELOPMENT LTD. (Israel)
Inventor
Skaliter, Rami
Hayoun Neeman, Dana
Wiser, Ofer
Reubinoff, Benjamin Eithan
Khaner, Hanita
Abstract
Described herein are methods for differentiating human pluripotent stem cells into populations of retinal cells comprising photoreceptor neural cells (PNCs) in dynamic culture. Also provided are cells and cellular compositions obtained by such methods, and uses of such cells in a suspension or imbedded in a scaffold that can be administered to a subject suffering from a retinal disease or disorder.
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in disease, condition and infection detection; Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in in vitro diagnostic (IVD) testing Medical testing for transplantation monitoring and transplantation therapy evaluation
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation; Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in kidney and liver transplantation monitoring and kidney and liver transplantation therapy evaluation Medical testing for transplantation monitoring and transplantation therapy evaluation; Medical testing for use in kidney and liver transplantation monitoring and kidney and liver transplantation therapy evaluation
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
05 - Pharmaceutical, veterinary and sanitary products
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation. Medical testing for transplantation monitoring and transplantation therapy evaluation.
20.
RPE CELL POPULATIONS AND METHODS OF GENERATING SAME
A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
Presented herein are methods and compositions for expanding RPE cells with the use of a suspendable cell support matrix. Also provided are pharmaceutical compositions containing RPE cells, and methods of treating an eye disorder or disease using RPE cells.
09 - Scientific and electric apparatus and instruments
Goods & Services
Pipette tips; Pipette tip racks; Racks and storage boxes for laboratory pipette tips, laboratory syringes, and laboratory capillaries; Laboratory syringes, namely, Disposable dispenser syringes for laboratory use; Laboratory capillaries, namely, Capillary tubes for samples for laboratory use, Capillary reagent tubes for laboratory use; Reload systems for pipette tips consisting of a pipette tip rack, rack base and snap cards; Refill systems for pipette tips, laboratory syringes, and laboratory capillaries comprising containers housing one or more arrays of pipette tips, laboratory syringes, or laboratory capillaries dispensable from the containers to refill empty racks and storage boxes; Snap cards, to be combined with pipette tip rack bases to form pipette tip racks; Snap cards holding pipette tips to be combined with pipette tip rack bases to form pipette tip racks; Laboratory vessels, namely, laboratory glassware, plastic storage tubes, sterile sampling bags, containers especially made for laboratory waste, filters for physical, chemical and biotechnical applications; Reservoirs, in particular reagent reservoirs; Laboratory tubes, in particular microcentrifuge tubes, centrifuge tubes, PCR-tubes; Laboratory vials, in particular vials for storing biological materials, vials for the preservation of specimens, Plates, in particular assay plates, deep well plates, PCR-plates, cell culture and storage plates
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Diagnostic reagents, other than for medical or veterinary purposes; diagnostic reagents for scientific or research use; reagents for scientific or medical research use Research use only chemical reagents for clinical medical or veterinary purposes; diagnostic reagents for medicinal research use Research use only biopsy tests and devices, namely, medical instruments for use in performing biopsies and medical diagnostic apparatus for evaluating appropriate immunotherapy cancer treatments; Research use only cancer screening tests and devices, namely, medical devices for evaluating immunotherapy cancer treatment options; Research use only cancer screening tests and devices, namely, medical devices for matching cancer diagnosis with cancer treatments; Research use only medical diagnostic apparatus for testing a patient's response to various immunotherapy cancer treatment options in order to help determine the most effective course of treatment for that patient Providing reagent sample testing and diagnostic services for others in the field of cancer testing research, tumor testing research, and screening for the purpose of evaluating patient immunotherapy cancer treatment options
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (Israel)
Inventor
Skaliter, Rami
Neeman, Dana Hayoun
Wiser, Ofer
Reubinoff, Benjamin Eithan
Khaner, Hanita
Abstract
Described herein are methods for differentiating human pluripotent stem cells into populations of retinal cells comprising photoreceptor neural cells (PNCs) in dynamic culture. Also provided are cells and cellular compositions obtained by such methods, and uses of such cells in a suspension or imbedded in a scaffold that can be administered to a subject suffering from a retinal disease or disorder.
The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
C07D 209/70 - [b]- or [c]-condensed containing carbocyclic rings other than six-membered
C09B 23/06 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups three CH groups, e.g. carbocyanines
C09B 23/08 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups more than three CH groups, e.g. polycarbocyanines
C09B 23/10 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an even number of CH groups
Cancer is the second leading cause of death in the United States. Increasingly, immune modulating therapies, such as therapy with immune checkpoint inhibitors (ICI) are being explored as promising potential therapies for many cancers. Presented herein are systems and methods for prediction, and especially automated prediction, of subject response to cancer therapies. Also presented herein are methods for selection of cancer therapies based upon predicted subject response and/or technologies for administering cancer therapies to appropriate subjects.
Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A method of qualifying whether a cell population is a suitable therapeutic for treating an eye condition is disclosed. The method comprises analyzing co-expression of premelanosome protein (PMEL17) and at least one polypeptide selected from the group consisting of cellular retinaldehyde binding protein (CRALBP), lecithin retinol acyltransferase (LRAT) and sex determining region Y-box 9 (SOX 9) in the population of cells.
A method of treating a subject with dry-form age-related macular degeneration (AMD) is disclosed. The method comprises administering into the subretina of the subject a therapeutically effective amount of a pharmaceutical composition comprising human RPE cells, wherein at least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), and wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms to the subject, thereby treating the subject.
A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in cancer therapy evaluation and transplantation monitoring and transplantation therapy evaluation.
Biopsy tests and devices, namely, medical instruments for use in performing biopsies and medical diagnostic apparatus for testing biomarkers; Biopsy tests and devices, namely, medical instruments for use in performing biopsies and medical diagnostic apparatus for evaluating appropriate immunotherapy cancer treatments; Cancer screening tests and devices, namely, medical devices for detecting risk factors and probability of cancer reoccurrence; Cancer screening tests and devices, namely, medical devices for evaluating immunotherapy cancer treatment options; Cancer screening tests and devices, namely, medical devices for matching cancer diagnosis with cancer treatments; Medical testing device for diagnosing cancer and detecting biological traits that effect the risk of reoccurrence; Medical diagnostic apparatus for testing a patient's response to various immunotherapy cancer treatment options in order to help determine the most effective course of treatment for that patient; Blood testing apparatus for cancer diagnosis and evaluation of treatment options; Medical testing devices for tumor diagnosis and treatment evaluation
42.
Efficiently nested pipette tip arrays and related methods
Provided in part herein are pipette tip rack assemblies having one or more of the following features: (i) having a plurality of pipette tip receptacle plates, each plate having an array of pipette tips, stacked upon one another supported by a rack base; (ii) each plate having one or more projections from the proximal or distal surface and, optionally, orifices that oppose the projections of the next plate in the stack, and (iii) the rack base having a proximal surface with one or more orifices or projections that oppose the projections or orifices of the plate in the stack. Also provided are methods of dispensing pipette tips from pipette tip rack assemblies and manufacturing pipette tip rack assembly components.
Presented herein are systems and methods for prediction, and especially automated prediction, of subject response to cancer therapies. Also presented herein are methods for selection of cancer therapies based upon predicted subject response and/or technologies for administering cancer therapies to appropriate subjects.
Provided herein is a pipette tip tray that includes a base and a connected pipette tip receptacle plate, where the base includes a plurality of axially-disposed base ribs disposed on two or more internal wall surfaces, the pipette receptacle plate includes a plurality of plate ribs disposed on the distal surface of the plate, and a portion of at least a subset of the plate ribs is in contact with at least a portion of an end of at least a subset of the base ribs.
B65D 85/30 - Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.
2O, where Fum—fumaric acid anion, Me—zinc, calcium or magnesium, n=0-8 or mixture of these. The B group can be B12, B6, B2, preferably, at least two of these. Preferably also including at least one amino acid from the following: glycine, L-glutamic acid and/or its salts, L-arginine and/or its salts, L-carnitine and/or its salts, asparagine and/or its salts. Preferably also succinic, citric or isocitric acid and/or their salts. Preferably also including other vitamins, fillers, ballast substances, flavors, colors, sugars, oils.
The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.
C09B 57/00 - Other synthetic dyes of known constitution
C09B 23/08 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups more than three CH groups, e.g. polycarbocyanines
C09B 23/06 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups three CH groups, e.g. carbocyanines
G01N 33/533 - Production of labelled immunochemicals with fluorescent label
Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
Provided herein is a single-walled pipette tip rack comprising buttresses for use in automated systems, in some embodiments. Also provided herein is a partial single-walled pipette tip rack comprising posts.
Disclosed herein are methods for detecting whether a subject is at risk of lung cancer based on a blood-based multivariate gene expression classifier. Methods for determining whether to obtain a biopsy in a subject based on a blood-based multivariate gene expression classifier are also disclosed. Further disclosed are methods for treating lung cancer based on a blood-based multivariate gene expression classifier are disclosed. Kits for detecting the expression levels of biomarkers for determining whether a subject is at risk of lung cancer are also disclosed.
Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
Provided in part herein are multiple-tube devices that contain a region of reduced wall thickness, which devices facilitate biological fluid processing and analysis. Also provided in part herein are methods of manufacturing and using such devices.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are pipette tip rack assemblies in which a plurality of pipette tip racks are contained within a transparent or translucent non-porous container. Also provided are methods for using and manufacturing pipette tip rack assemblies described herein.
Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
Disclosed here are pipette tips (100) useful for receiving and dispensing liquids, which include a plurality of interior ribs (155) with beveled proximal surfaces (163) in a proximal region of the pipette tip.
Biopsy tests and devices, namely, medical instruments for use in performing tissue biopsies and medical diagnostic apparatus for testing biomarkers; cancer screening tests and devices, namely, medical devices for detecting risk factors and probability of cancer reoccurrence; medical testing device for diagnosing cancer and detecting bioloigical traits that effect the risk of reoccurrence; medical testing devices for tumor diagnosis
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing reagent sample testing and diagnostic services for others in the field of cancer testing, tumor testing, and screening for the purpose of evaluating risk factors, the probability of cancer reoccurrence, and need for subsequent therapeutic treatment
Provided herein is a pipette tip tray that includes a base and a connected pipette tip receptacle plate, where the base includes a plurality of axially-disposed base ribs disposed on two or more internal wall surfaces, the pipette receptacle plate includes a plurality of plate ribs disposed on the distal surface of the plate, and a portion of at least a subset of the plate ribs is in contact with at least a portion of an end of at least a subset of the base ribs.
B65D 85/30 - Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
Provided herein is a pipette tip tray that includes a base and a connected pipette tip receptacle plate, where the base includes a plurality of axially-disposed base ribs disposed on two or more internal wall surfaces, the pipette receptacle plate includes a plurality of plate ribs disposed on the distal surface of the plate, and a portion of at least a subset of the plate ribs is in contact with at least a portion of an end of at least a subset of the base ribs.
Provided herein are methods, compositions and kits for labeling of target proteins such as antibodies. The methods, compositions and kits are suited for labeling of such proteins that are mixed with other non-target molecules including BSA, gelatin, and other complex biological molecules.
Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
G06F 19/20 - for hybridisation or gene expression, e.g. microarrays, sequencing by hybridisation, normalisation, profiling, noise correction models, expression ratio estimation, probe design or probe optimisation
Provided herein are cap and tube component embodiments that permit ergonomic engagement and disengagement. Also provided herein are assemblies thereof in which a cap is in sealing engagement with a tube. When engaged with a tube, a cap may be pivoted with respect to a point located on the interior rim of the tube opening by applying a relatively small force to the exterior surface of the cap. Pivoting the cap at this point on the tube can break the seal between the tube and cap and permit removal of the cap from the tube for manipulation of fluid in the tube.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.
