Cancer is the second leading cause of death in the United States. Increasingly, immune modulating therapies, such as therapy with immune checkpoint inhibitors (ICI) are being explored as promising potential therapies for many cancers. Presented herein are systems and methods for prediction, and especially automated prediction, of subject response to cancer therapies. Also presented herein are methods for selection of cancer therapies based upon predicted subject response and/or technologies for administering cancer therapies to appropriate subjects.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16B 20/00 - TIC spécialement adaptées à la génomique ou protéomique fonctionnelle, p. ex. corrélations génotype-phénotype
G16B 25/10 - Profilage de l’expression de gènes ou de protéinesEstimation ou normalisation de ratio d’expression
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in disease, condition and infection detection; Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in in vitro diagnostic (IVD) testing Medical testing for transplantation monitoring and transplantation therapy evaluation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Research use only transplant test kits using digital polymerase chain reaction technology to measure and test the concentration of donor-derived cell free DNA in a single nucleotide polymorphism gene; test kits for use in measuring DNA levels for transplant research purposes; Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation Medical testing for transplantation monitoring and transplantation therapy evaluation.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in disease, condition and infection detection; Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in in vitro diagnostic (IVD) testing Medical testing for transplantation monitoring and transplantation therapy evaluation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation; Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in kidney and liver transplantation monitoring and kidney and liver transplantation therapy evaluation Medical testing for transplantation monitoring and transplantation therapy evaluation; Medical testing for use in kidney and liver transplantation monitoring and kidney and liver transplantation therapy evaluation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Research use only transplant test kits using digital polymerase chain reaction technology to measure and test the concentration of donor-derived cell free DNA in a single nucleotide polymorphism gene; test kits for use in measuring DNA levels for transplant research purposes; Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation Medical testing for transplantation monitoring and transplantation therapy evaluation.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation; Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in kidney and liver transplantation monitoring and kidney and liver transplantation therapy evaluation Medical testing for transplantation monitoring and transplantation therapy evaluation; Medical testing for use in kidney and liver transplantation monitoring and kidney and liver transplantation therapy evaluation
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation. Medical testing for transplantation monitoring and transplantation therapy evaluation.
12.
RPE CELL POPULATIONS AND METHODS OF GENERATING SAME
A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
Presented herein are methods and compositions for expanding RPE cells with the use of a suspendable cell support matrix. Also provided are pharmaceutical compositions containing RPE cells, and methods of treating an eye disorder or disease using RPE cells.
09 - Appareils et instruments scientifiques et électriques
Produits et services
(Based on use) Pipette tips; Pipette tip racks; Racks and storage boxes for laboratory pipette tips, laboratory syringes, and laboratory capillaries; (based on an intent to use) Laboratory syringes; Laboratory capillaries; Reload systems for pipette tips; Reload systems for pipette tips consisting of a pipette tip rack, rack base and snap cards; Refill systems for pipette tips, laboratory syringes, and laboratory capillaries comprising containers housing one or more arrays of pipette tips, laboratory syringes, or laboratory capillaries dispensable from the containers to refill empty racks and storage boxes; Snap cards, to be combined with pipette tip rack bases to form pipette tip racks; Snap cards holding pipette tips; to be combined with pipette tip rack bases to form pipette tip racks; Laboratory vessels for physical, chemical and biotechnical applications; Reservoirs; in particular reagent reservoirs; Laboratory tubes, in particular microcentrifuge tubes; centrifuge tubes; PCR-tubes; Laboratory vials, in particular vials for storing biological materials; vials for the preservation of specimens; Plates, in particular assay plates, deep well plates, PCR-plates, cell culture and storage plates
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Diagnostic reagents, other than for medical or veterinary purposes; diagnostic reagents for scientific or research use; reagents for scientific or medical research use Research use only chemical reagents for clinical medical or veterinary purposes; diagnostic reagents for medicinal research use Research use only biopsy tests and devices, namely, medical instruments for use in performing biopsies and medical diagnostic apparatus for evaluating appropriate immunotherapy cancer treatments; Research use only cancer screening tests and devices, namely, medical devices for evaluating immunotherapy cancer treatment options; Research use only cancer screening tests and devices, namely, medical devices for matching cancer diagnosis with cancer treatments; Research use only medical diagnostic apparatus for testing a patient's response to various immunotherapy cancer treatment options in order to help determine the most effective course of treatment for that patient Providing reagent sample testing and diagnostic services for others in the field of cancer testing research, tumor testing research, and screening for the purpose of evaluating patient immunotherapy cancer treatment options
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Diagnostic reagents, other than for medical or veterinary purposes; diagnostic reagents for scientific or research use; reagents for scientific or medical research use Research use only chemical reagents for clinical medical or veterinary purposes; diagnostic reagents for medicinal research use Research use only biopsy tests and devices, namely, medical instruments for use in performing biopsies and medical diagnostic apparatus for evaluating appropriate immunotherapy cancer treatments; Research use only cancer screening tests and devices, namely, medical devices for evaluating immunotherapy cancer treatment options; Research use only cancer screening tests and devices, namely, medical devices for matching cancer diagnosis with cancer treatments; Research use only medical diagnostic apparatus for testing a patient's response to various immunotherapy cancer treatment options in order to help determine the most effective course of treatment for that patient Providing reagent sample testing and diagnostic services for others in the field of cancer testing research, tumor testing research, and screening for the purpose of evaluating patient immunotherapy cancer treatment options
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Research use only transplant test kits using digital polymerase chain reaction technology to measure and test the concentration of donor-derived cell free DNA in a single nucleotide polymorphism gene; test kits for use in measuring DNA levels for transplant research purposes; Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Research use only transplant test kits using digital polymerase chain reaction technology to measure and test the concentration of donor-derived cell free DNA in a single nucleotide polymorphism gene; test kits for use in measuring DNA levels for transplant research purposes; Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation
Presented herein are systems and methods for prediction, and especially automated prediction, of subject response to cancer therapies. Also presented herein are methods for selection of cancer therapies based upon predicted subject response and/or technologies for administering cancer therapies to appropriate subjects.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
C09B 23/10 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre pair de groupes CH
C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
C09B 23/06 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH trois groupes CH, p. ex. carbocyanines
C07D 209/70 - Systèmes cycliques contenant au moins trois cycles condensés en [b] ou en [c] contenant des carbocycles autres que des cycles à six chaînons
Presented herein are systems and methods for prediction, and especially automated prediction, of subject response to cancer therapies. Also presented herein are methods for selection of cancer therapies based upon predicted subject response and/or technologies for administering cancer therapies to appropriate subjects.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
Cancer is the second leading cause of death in the United States. Increasingly, immune modulating therapies, such as therapy with immune checkpoint inhibitors (ICI) are being explored as promising potential therapies for many cancers. Presented herein are systems and methods for prediction, and especially automated prediction, of subject response to cancer therapies. Also presented herein are methods for selection of cancer therapies based upon predicted subject response and/or technologies for administering cancer therapies to appropriate subjects.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Diagnostic reagents, other than for medical or veterinary purposes; diagnostic reagents for scientific or research use; reagents for scientific or medical research use Chemical reagents for medical or veterinary purposes; clinical medical reagents; diagnostic reagents for medicinal use; medical diagnostic reagents; reagents for medical use Biopsy tests and devices, namely, medical instruments for use in performing biopsies and medical diagnostic apparatus for evaluating appropriate immunotherapy cancer treatments; Cancer screening tests and devices, namely, medical devices for evaluating immunotherapy cancer treatment options; Cancer screening tests and devices, namely, medical devices for matching cancer diagnosis with cancer treatments; Medical diagnostic apparatus for testing a patient's response to various immunotherapy cancer treatment options in order to help determine the most effective course of treatment for that patient Providing reagent sample testing and diagnostic services for others in the field of cancer testing, tumor testing, and screening for the purpose of evaluating patient immunotherapy cancer treatment options
Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A method of qualifying whether a cell population is a suitable therapeutic for treating an eye condition is disclosed. The method comprises analyzing co-expression of premelanosome protein (PMEL17) and at least one polypeptide selected from the group consisting of cellular retinaldehyde binding protein (CRALBP), lecithin retinol acyltransferase (LRAT) and sex determining region Y-box 9 (SOX 9) in the population of cells.
A method of treating a subject with dry-form age-related macular degeneration (AMD) is disclosed. The method comprises administering into the subretina of the subject a therapeutically effective amount of a pharmaceutical composition comprising human RPE cells, wherein at least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), and wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms to the subject, thereby treating the subject.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
A61K 35/30 - NerfsCerveauYeuxCellules cornéennesLiquide céphalorachidienCellules souches neuronalesCellules précurseurs neuronalesCellules glialesOligodendrocytesCellules de SchwannAstrogliesAstrocytesPlexus choroïdeTissu de moelle épinière
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation Medical testing for transplantation monitoring and transplantation therapy evaluation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation Medical testing for transplantation monitoring and transplantation therapy evaluation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation Medical testing for transplantation monitoring and transplantation therapy evaluation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in transplantation monitoring and transplantation therapy evaluation Medical testing for transplantation monitoring and transplantation therapy evaluation
A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Medical diagnostic test kits comprised of medical diagnostic reagents and assays for testing blood for use in cancer therapy evaluation and transplantation monitoring and transplantation therapy evaluation.
Biopsy tests and devices, namely, medical instruments for use in performing biopsies and medical diagnostic apparatus for testing biomarkers; Biopsy tests and devices, namely, medical instruments for use in performing biopsies and medical diagnostic apparatus for evaluating appropriate immunotherapy cancer treatments; Cancer screening tests and devices, namely, medical devices for detecting risk factors and probability of cancer reoccurrence; Cancer screening tests and devices, namely, medical devices for evaluating immunotherapy cancer treatment options; Cancer screening tests and devices, namely, medical devices for matching cancer diagnosis with cancer treatments; Medical testing device for diagnosing cancer and detecting biological traits that effect the risk of reoccurrence; Medical diagnostic apparatus for testing a patient's response to various immunotherapy cancer treatment options in order to help determine the most effective course of treatment for that patient; Blood testing apparatus for cancer diagnosis and evaluation of treatment options; Medical testing devices for tumor diagnosis and treatment evaluation
Presented herein are systems and methods for prediction, and especially automated prediction, of subject response to cancer therapies. Also presented herein are methods for selection of cancer therapies based upon predicted subject response and/or technologies for administering cancer therapies to appropriate subjects.
Provided in part herein are pipette tip rack assemblies having one or more of the following features: (i) having a plurality of pipette tip receptacle plates, each plate having an array of pipette tips, stacked upon one another supported by a rack base; (ii) each plate having one or more projections from the proximal or distal surface and, optionally, orifices that oppose the projections of the next plate in the stack, and (iii) the rack base having a proximal surface with one or more orifices or projections that oppose the projections or orifices of the plate in the stack. Also provided are methods of dispensing pipette tips from pipette tip rack assemblies and manufacturing pipette tip rack assembly components.
B65D 85/00 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers
G01N 1/28 - Préparation d'échantillons pour l'analyse
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
Presented herein are systems and methods for prediction, and especially automated prediction, of subject response to cancer therapies. Also presented herein are methods for selection of cancer therapies based upon predicted subject response and/or technologies for administering cancer therapies to appropriate subjects.
Provided herein is a pipette tip tray that includes a base and a connected pipette tip receptacle plate, where the base includes a plurality of axially-disposed base ribs disposed on two or more internal wall surfaces, the pipette receptacle plate includes a plurality of plate ribs disposed on the distal surface of the plate, and a portion of at least a subset of the plate ribs is in contact with at least a portion of an end of at least a subset of the base ribs.
B65D 85/30 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour objets particulièrement sensibles aux dommages par chocs ou compression
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 9/00 - Dispositifs de supportDispositifs de serrage
B65D 25/10 - Dispositifs pour placer les objets dans les réceptacles
B65D 43/16 - Couvercles ou chapeaux inamovibles s'ouvrant à charnières vers le haut ou vers le bas
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.
2O, where Fum—fumaric acid anion, Me—zinc, calcium or magnesium, n=0-8 or mixture of these. The B group can be B12, B6, B2, preferably, at least two of these. Preferably also including at least one amino acid from the following: glycine, L-glutamic acid and/or its salts, L-arginine and/or its salts, L-carnitine and/or its salts, asparagine and/or its salts. Preferably also succinic, citric or isocitric acid and/or their salts. Preferably also including other vitamins, fillers, ballast substances, flavors, colors, sugars, oils.
The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.
G01N 33/532 - Production de composés immunochimiques marqués
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
C09B 11/24 - Phtaléines contenant des groupes amine
C09B 57/00 - Autres colorants synthétiques de structure connue
C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
C09B 23/06 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH trois groupes CH, p. ex. carbocyanines
G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Diagnostic reagents for clinical or medical laboratory use; diagnostic reagents for scientific or research use; reagents for scientific or medical research use Chemical reagents for medical or veterinary purposes; clinical medical reagents; diagnostic reagents for medicinal use; medical diagnostic reagents; reagents for medical use Biopsy tests and devices, namely, medical instruments for use in performing blood-based testing and medical diagnostic apparatus for testing changes in biomarkers; cancer screening tests and devices, namely, medical devices for post-cancer treatment reoccurrence monitoring; medical diagnostic apparatus for testing patients' post-cancer treatment biomarkers Providing blood reagent sample testing and diagnostic services for others in the field of cancer testing, tumor testing, and screening for the purpose of monitoring patients post-treatment for the probability of cancer reoccurrence Medical services, namely, providing blood testing and diagnostic services for others in the field of cancer testing, tumor testing, and screening for the purpose of monitoring patients post-treatment for the probability of cancer reoccurrence
Provided herein is a single-walled pipette tip rack comprising buttresses for use in automated systems, in some embodiments. Also provided herein is a partial single-walled pipette tip rack comprising posts.
Disclosed herein are methods for detecting whether a subject is at risk of lung cancer based on a blood-based multivariate gene expression classifier. Methods for determining whether to obtain a biopsy in a subject based on a blood-based multivariate gene expression classifier are also disclosed. Further disclosed are methods for treating lung cancer based on a blood-based multivariate gene expression classifier are disclosed. Kits for detecting the expression levels of biomarkers for determining whether a subject is at risk of lung cancer are also disclosed.
Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Provided in part herein are static-defeating apparatus for use in multipipettor systems. Multiple pipette tips can be retained by a static-defeating sheet of material. A multipipettor, having multiple pipettes or nozzles, can engage the pipette tips retained by the sheet. After use, the multipipettor can eject the pipette tips, which sometimes are ejected as a single unit due to the pipette tips being retained by the sheet. In certain embodiments, an apparatus includes a snap plate having one or more holes, and a base rack for ease of mounting.
Provided in part herein are multiple-tube devices that contain a region of reduced wall thickness, which devices facilitate biological fluid processing and analysis. Also provided in part herein are methods of manufacturing and using such devices.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are pipette tip rack assemblies in which a plurality of pipette tip racks are contained within a transparent or translucent non-porous container. Also provided are methods for using and manufacturing pipette tip rack assemblies described herein.
B29C 45/00 - Moulage par injection, c.-à-d. en forçant un volume déterminé de matière à mouler par une buse d'injection dans un moule ferméAppareils à cet effet
B29C 51/04 - Thermoformage combiné avec un pré-étirage, p. ex. étirage biaxial
Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
Disclosed here are pipette tips (100) useful for receiving and dispensing liquids, which include a plurality of interior ribs (155) with beveled proximal surfaces (163) in a proximal region of the pipette tip.
Biopsy tests and devices, namely, medical instruments for use in performing tissue biopsies and medical diagnostic apparatus for testing biomarkers; cancer screening tests and devices, namely, medical devices for detecting risk factors and probability of cancer reoccurrence; medical testing device for diagnosing cancer and detecting bioloigical traits that effect the risk of reoccurrence; medical testing devices for tumor diagnosis
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Providing reagent sample testing and diagnostic services for others in the field of cancer testing, tumor testing, and screening for the purpose of evaluating risk factors, the probability of cancer reoccurrence, and need for subsequent therapeutic treatment
Provided herein is a pipette tip tray that includes a base and a connected pipette tip receptacle plate, where the base includes a plurality of axially-disposed base ribs disposed on two or more internal wall surfaces, the pipette receptacle plate includes a plurality of plate ribs disposed on the distal surface of the plate, and a portion of at least a subset of the plate ribs is in contact with at least a portion of an end of at least a subset of the base ribs.
B65D 85/30 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour objets particulièrement sensibles aux dommages par chocs ou compression
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 9/00 - Dispositifs de supportDispositifs de serrage
B65D 25/10 - Dispositifs pour placer les objets dans les réceptacles
B65D 43/16 - Couvercles ou chapeaux inamovibles s'ouvrant à charnières vers le haut ou vers le bas
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Provided herein is a pipette tip tray that includes a base and a connected pipette tip receptacle plate, where the base includes a plurality of axially-disposed base ribs disposed on two or more internal wall surfaces, the pipette receptacle plate includes a plurality of plate ribs disposed on the distal surface of the plate, and a portion of at least a subset of the plate ribs is in contact with at least a portion of an end of at least a subset of the base ribs.
B01L 9/00 - Dispositifs de supportDispositifs de serrage
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
87.
Methods, compositions and kits for labeling of proteins
Provided herein are methods, compositions and kits for labeling of target proteins such as antibodies. The methods, compositions and kits are suited for labeling of such proteins that are mixed with other non-target molecules including BSA, gelatin, and other complex biological molecules.
Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 35/30 - NerfsCerveauYeuxCellules cornéennesLiquide céphalorachidienCellules souches neuronalesCellules précurseurs neuronalesCellules glialesOligodendrocytesCellules de SchwannAstrogliesAstrocytesPlexus choroïdeTissu de moelle épinière
Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
G06F 19/20 - pour l'hybridation ou l'expression génique, p.ex. microréseaux, séquençage par hybridation, normalisation, profilage, modèles de correction de bruit, estimation du ratio d'expression, conception ou optimisation de sonde
Provided herein are cap and tube component embodiments that permit ergonomic engagement and disengagement. Also provided herein are assemblies thereof in which a cap is in sealing engagement with a tube. When engaged with a tube, a cap may be pivoted with respect to a point located on the interior rim of the tube opening by applying a relatively small force to the exterior surface of the cap. Pivoting the cap at this point on the tube can break the seal between the tube and cap and permit removal of the cap from the tube for manipulation of fluid in the tube.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
Provided herein are fluid handling tubes having a cap that includes a sealing member having interior grooves and panels. Also provided herein are fluid handling tubes having a cap that includes (i) a sealing member having a concave surface at a distal region, and (ii) a flat proximal surface. Provided also are fluid handling tubes having a cap that includes an engagement member at an edge of the cap, where the engagement member includes a surface having curvature and a taper. Also provided herein are fluid handling tubes that include a cap comprising a tube sealing member, an anterior engagement member, and one or more channels (e.g., one or more furrows or grooves) between the sealing member and the engagement member that function as a hinge or pivot. Also provided are fluid handling tubes that include (i) a cap having a sealing member that includes an annular protrusion, and (ii) a tube body having an interior surface that includes an annular recess, where the annular recess in the tube body is configured to receive the annular protrusion of the tubular sealing member of the cap.
