Produits et services

Contract manufacturing of pharmaceutical products; contract manufacturing of pre-filled syringes containing pharmaceutical preparations; manufacture, for others, of pharmaceutical and biopharmaceutical preparations; Manufacture for others of pharmaceuticals; manufacture for others of products relating to biotechnology; manufacture for others of cell therapy products; manufacture for others of gene therapy products; pharmaceutical manufacturing in accordance with GMP regulations. Pharmaceutical research services; research and development of pharmaceutical products; development of products; Contract development and manufacturing organization (CDMO) services; consulting and advisory services in the field of analytical development and quality control testing of pharmaceutical, gene therapy, and cell therapy products; consulting and advisory services in the field of manufacturing process development for pharmaceutical, gene therapy and cell therapy products; consulting in the field of chemistry manufacturing and controls (CMC) activities; testing of pharmaceutical, gene therapy, and cell therapy products and materials; quality control testing of pharmaceutical products and materials; testing and validation services for pharmaceutical, cell therapy and gene therapy methods of development.

Abrégé

A transfer device (10) for removing or transferring a medium out of or into a bottle (20) having a bottle neck (34) that can be closed by means of a closure (42), including a first adapter part (12), which can be positioned on the bottle, and a second adapter part (14), which interacts with the first adapter part, which can be displaced in the longitudinal direction of the bottle, and has a conducting element (50) for piercing the closure. After the second adapter part (14) has been displaced along the first adapter part in the direction of the closure (42) and the second adapter part has been locked, the first adapter part (12) is non-releasably fastened to or around the bottle (20).

Classes IPC  ?

• A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue
• A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques DétailsAccessoires à cet effet
• A61J 1/16 - Supports pour récipients

Abrégé

Disclosed is a process for preparing new crystal salt forms of sulfasalazine, in particular a crystal Form A of the D(−)-N-methylglucamine (meglumine) salt of sulfasalazine, a crystal form A of the piperazine salt of sulfasalazine and a crystal Form B of the diethylamine salt of sulfasalazine, and the use thereof in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and/or the gastro-intestinal tract.

Classes IPC  ?

• A61K 31/4402 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 2, p. ex. phéniramine, bisacodyl
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• C07D 213/76 - Atomes d'azote auxquels est lié un second hétéro-atome

Produits et services

Pharmaceuticals; Pharmaceuticals and natural remedies. Medical apparatus and instruments; Equipment, containers and bags for the reconstitution of medicinal products for intravesical use.

Produits et services

Pharmaceutical preparations for conditioning therapy prior hematopoietic stem cell transplantation

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceuticals.

Produits et services

Downloadable and recorded content; Computer databases; Software; Application software; apps; Web application and server software; Information technology and audio-visual, multimedia and photographic devices; Apparatus, instruments and cables for electricity; Scientific research and laboratory apparatus, educational apparatus and simulators. Human healthcare services; Medical services; Pharmaceutical services; Mental health services; Human hygiene and beauty care.

Abrégé

The present invention relates to a pressure measuring device (10) including an elastic body (12) having a wall (14) which defines a lumen (16) arranged within the elastic body (12), the lumen (16) being fillable with a compressible fluid. The lumen (16) is configured to be compressed by a body part of a user to compress the compressible fluid. A pressure detection device (20) is configured to detect a pressure in the lumen (16). The pressure measuring device (10) further includes a connection member (24) arranged within an opening (26) formed in and attached to the wall (14), the connection member (24) being operatively connectable to an electrical component (20, 28) of the pressure measuring device (10) and connectable to an external power source (30). The connection member (24) has an outer contour (32) which is curved, with respect to a direction which extends along a longitudinal axis (34) of the opening (26), at an interface (36) between the wall (14) and the connection member (24).

Classes IPC  ?

• G01L 1/02 - Mesure des forces ou des contraintes, en général par des moyens hydrauliques ou pneumatiques
• A61B 5/22 - ErgométrieMesure de la force musculaire ou de la force d'un coup musculaire

Produits et services

Pharmaceutical preparations.

Abrégé

The present invention relates to a pressure measuring device (100; 200) for monitoring a medical condition of a user related to arthritis and/or arthrosis. The pressure measuring device (100; 200) comprises an elastic body (102; 202) defining a lumen (104; 204) filled with a compressible fluid. The lumen (104; 204) is configured to be compressed by at least one body part of a user. The pressure measuring device (100; 200) further comprises a pressure detection device (112; 212) arranged at least partially within the lumen (104; 204), the pressure detection device (112; 212) being configured to detect at least one absolute pressure in the lumen (104; 204), generate a pressure signal based on the detected absolute pressure, and provide the pressure signal to an evaluating device (114) for evaluating the pressure signal. The pressure measuring device (100; 200) further comprises an energy source arranged within the elastic body (102; 202).

Classes IPC  ?

• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/22 - ErgométrieMesure de la force musculaire ou de la force d'un coup musculaire

Abrégé

Disclosed is a process for preparing new crystal salt forms of sulfasalazine, in particular a crystal Form A of the D(−)-N-methylglucamine (meglumine) salt of sulfasalazine, a crystal form A of the piperazine salt of sulfasalazine and a crystal Form B of the diethylamine salt of sulfasalazine, and the use thereof in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and/or the gastro-intestinal tract.

Classes IPC  ?

• A61K 31/4402 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 2, p. ex. phéniramine, bisacodyl
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• C07D 213/76 - Atomes d'azote auxquels est lié un second hétéro-atome

Produits et services

Recorded content; Databases; Software; Application software; apps; Web application and server software; Information technology and audio-visual, multimedia and photographic devices; Apparatus, instruments and cables for electricity; Scientific research and laboratory apparatus, educational apparatus and simulators. Physical therapy equipment; Medical and veterinary apparatus and instruments; Mobility aids. IT services; Science and technology services; Testing, authentication and quality control; Design services. Human healthcare services; Human hygiene and beauty care.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceuticals.

Abrégé

A lyophilisate of treosulfan is described which possesses favourable characteristics in terms of a short reconstitution time and a high purity and stability and which is particularly useful in the treatment of cancer and for conditioning therapy before transplantation of bone marrow or blood stem cells.

Classes IPC  ?

• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
• C07C 309/08 - Acides sulfoniques ayant des groupes sulfo liés à des atomes de carbone acycliques d'un squelette carboné acyclique saturé contenant des atomes d'oxygène liés au squelette carboné contenant des groupes hydroxy liés au squelette carboné

Abrégé

A crystalline form of treosulfan and methods to prepare it are described. This crystalline form of treosulfan is useful in pharmaceutical compositions for the treatment of cancer and for conditioning therapy before transplantation of bone marrow or blood stem cells.

Classes IPC  ?

• C07C 309/66 - Méthanesulfonates
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées

Abrégé

Disclosed is to a new pharmaceutical composition for oral administration containing sulfasalazine and/or a sulfasalazine organic salt, production processes and uses, in particular in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and/or the gastro-intestinal tract.

Classes IPC  ?

• A61K 31/655 - Composés azoïques(-N=N-), diazoïques (=N2), azoxy (N-O-N ou N(=O)-N), azido (-N3) ou diazoamino (-N=N-N)
• A61K 33/242 - OrSes composés
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 9/28 - DragéesPilules ou comprimés avec revêtements
• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• A61K 9/50 - Microcapsules
• A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
• A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
• A61K 31/415 - 1,2-Diazoles
• A61K 31/42 - Oxazoles
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/5415 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame condensés en ortho ou en péri avec des systèmes carbocycliques, p. ex. phénothiazine, chlorpromazine, piroxicam
• A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
• A61K 31/616 - Acide salicyliqueSes dérivés ayant le groupe hydroxyle en position 2 estérifié, p. ex. acide salicylsulfurique par des acides carboxyliques, p. ex. acide acétylsalicylique
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire

Produits et services

Pharmaceutical preparations for treating and diagnosing cancer, autoimmune diseases, urologic diseases; pharmaceutical preparations for use in fibrinolysis, hematology and dermatology

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceuticals.

Abrégé

Disclosed are a process for preparing new crystal salt forms of sulfasalazine, in particular crystal Form A of the D(−)-N-methylglucamine (meglumine) salt of sulfasalazine (see FIG. 1), crystal form A of the piperazine salt of sulfasalazine (see FIG. 2) and crystal Form B of the diethylamine salt of sulfasalazine (see FIG. 4), and a pharmaceutical composition containing one or more of the inventive crystal salt forms in particular in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and/or the gastro-intestinal tract.

Classes IPC  ?

• A61K 31/4402 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 2, p. ex. phéniramine, bisacodyl
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• C07D 213/76 - Atomes d'azote auxquels est lié un second hétéro-atome

Produits et services

Medicines and pharmaceutical preparations; Veterinary preparations; Chemicals for medical use; Sanitary preparations for medical purposes; Sanitary preparations for medical purposes; Foodstuffs and dietetic substances for medical or veterinary purposes; Infant formula; Dietary supplements for humans; Dietary supplements for animals; Plasters, materials for dressings; Dressings, medical; Teeth filling material; Dental impression materials; Disinfectants; Fungicides; Herbicides; Vermin destroying preparations.

Produits et services

Medicines and pharmaceutical preparations; Veterinary preparations; Chemicals for medical use; Sanitary preparations for medical purposes; Sanitary preparations for medical purposes; Foodstuffs and dietetic substances for medical or veterinary purposes; Infant formula; Dietary supplements for humans; Dietary supplements for animals; Plasters, materials for dressings; Dressings, medical; Teeth filling material; Dental impression materials; Disinfectants; Fungicides; Herbicides; Vermin destroying preparations.

Produits et services

(1) Pharmaceutical preparations for Conditioning Therapy prior to Hematopoietic Stem Cell Transplantation

Produits et services

Medicine.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceuticals.

Abrégé

A transfer device (10) for removing or transferring a medium out of or into a bottle (20) having a bottle neck (34) that can be closed by means of a closure (42), including a first adapter part (12), which can be positioned on the bottle, and a second adapter part (14), which interacts with the first adapter part, which can be displaced in the longitudinal direction of the bottle, and has a conducting element (50) for piercing the closure. After the second adapter part (14) has been displaced along the first adapter part in the direction of the closure (42) and the second adapter part has been locked, the first adapter part (12) is non-releasably fastened to or around the bottle (20).

Classes IPC  ?

• A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques DétailsAccessoires à cet effet
• A61J 1/16 - Supports pour récipients
• A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue

Abrégé

A process is described for the preparation of freeze-dried pharmaceutical compositions of mitomycin C, which are characterized by high stability and can be rapidly reconstituted to form solutions.

Classes IPC  ?

• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
• A61K 31/435 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 31/407 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil condensés avec des systèmes hétérocycliques, p. ex. kétorolac, physostigmine
• A61K 9/08 - Solutions
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine

Produits et services

(1) Pharmaceutical preparations for Conditioning Therapy prior Hematopoietic Stem Cell Transplantation

Abrégé

A crystalline form of treosulfan and methods to prepare it are described. This crystalline form of treosulfan is useful in pharmaceutical compositions for the treatment of cancer and for conditioning therapy before transplantation of bone marrow or blood stem cells.

Classes IPC  ?

• A61K 9/08 - Solutions
• A61K 31/255 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides oxygénés du soufre ou de leurs thio-analogues
• A61P 35/00 - Agents anticancéreux
• C07C 309/66 - Méthanesulfonates

Abrégé

A crystalline form of treosulfan and methods to prepare it are described. This crystalline form of treosulfan is useful in pharmaceutical compositions for the treatment of cancer and for conditioning therapy before transplantation of bone marrow or blood stem cells.

Classes IPC  ?

• A61P 35/00 - Agents anticancéreux
• C07C 309/66 - Méthanesulfonates
• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques

Abrégé

A solution is described which comprises treosulfan and a mixture of water and acetic acid and leads, upon freeze-drying, to a lyophilisate which possesses favourable characteristics in terms of a short reconstitution time and a high purity and stability and which is particularly useful in the treatment of cancer and for conditioning therapy before transplantation of bone marrow or blood stem cells.

Classes IPC  ?

• A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
• A61K 9/08 - Solutions
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
• A61K 31/255 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides oxygénés du soufre ou de leurs thio-analogues

Abrégé

A lyophilisate of treosulfan is described which possesses favourable characteristics in terms of a short reconstitution time and a high purity and stability and which is particularly useful in the treatment of cancer and for conditioning therapy before transplantation of bone marrow or blood stem cells.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées

Abrégé

A lyophilisate of treosulfan is described which possesses favourable characteristics in terms of a short reconstitution time and a high purity and stability and which is particularly useful in the treatment of cancer and for conditioning therapy before transplantation of bone marrow or blood stem cells.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées

Produits et services

Pharmaceutical and veterinary preparations; Sanitary preparations for medical purposes; Dietetic foodstuffs and substances adapted for medical use; Infant formula; Dietary supplements for humans; Plasters, materials for dressings; Dressings, medical; Teeth filling material; Dental impression materials; Disinfectants.

Abrégé

The present invention relates to new crystal salt forms of sulfasalazine, in particular crystal Form A of the D(-)-N-methylglucamine (meglumine) salt of sulfasalazine (see Figure 1), crystal form A of the piperazine salt of sulfasalazine (see Figure 2) and crystal Form B of the diethylamine salt of sulfasalazine (see Figure 4), which can be obtained by use of the inventive preparation pro- cess, a pharmaceutical composition comprising one or more of the inventive crystal salt forms in particular in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and/or the gastro-intestinal tract.

Classes IPC  ?

• C07D 213/76 - Atomes d'azote auxquels est lié un second hétéro-atome

Abrégé

The present invention relates to a new pharmaceutical composition for oral administration containing sulfasalazine and/or a sulfasalazine organic salt, production processes and uses,in particular in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and/or the gastro-intestinal tract.

Classes IPC  ?

• A61K 9/08 - Solutions
• A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]

Abrégé

The present invention relates to a new pharmaceutical composition for oral administration containing sulfasalazine and/or a sulfasalazine organic salt, production processes and uses,in particular in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and/or the gastro-intestinal tract.

Classes IPC  ?

• A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 9/08 - Solutions
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses

Abrégé

The present invention relates to new crystal salt forms of sulfasalazine, in particular crystal Form A of the D(-)-N-methylglucamine (meglumine) salt of sulfasalazine (see Figure 1), crystal form A of the piperazine salt of sulfasalazine (see Figure 2) and crystal Form B of the diethylamine salt of sulfasalazine (see Figure 4), which can be obtained by use of the inventive preparation pro- cess, a pharmaceutical composition comprising one or more of the inventive crystal salt forms in particular in the treatment of a disease or condition in which modulation of inflammatory cells is beneficial, a disease or condition concerning bones or joints and/or the gastro-intestinal tract.

Classes IPC  ?

• C07D 213/76 - Atomes d'azote auxquels est lié un second hétéro-atome

Produits et services

Computer software; Interactive computer systems. Educational instruction. Advisory services relating to computer programming; Computer software research; Software development. Medical services; Medical consultations; Medical services for the diagnosis of conditions of the human body; Professional consultancy relating to health care; Monitoring of patients; Professional consultancy relating to health; Advisory services relating to health.

Produits et services

Pharmaceutical preparations for conditioning therapy prior hematopoietic stem cell transplantation

Produits et services

Pharmaceutical preparations.

Produits et services

Pharmaceuticals; Medical preparations.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceutical preparations; medicines; chemical preparations for medical purposes; plasters, materials for dressing; disinfectants.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceutical products.

Produits et services

Pharmaceuticals; Veterinary preparations; Sanitary preparations for medical purposes; Foodstuffs and dietetic substances for medical or veterinary purposes; Infant formula; Dietary supplements for humans; Dietary supplements for animals; Plasters, materials for dressings; Dressings, medical; Teeth filling material; Dental impression materials; Disinfectants; Fungicides; Herbicides; Preparations for destroying vermin.

Produits et services

Pharmaceuticals; Veterinary preparations; Sanitary preparations for medical purposes; Foodstuffs and dietetic substances for medical or veterinary purposes; Infant formula; Dietary supplements for humans; Dietary supplements for animals; Plasters, materials for dressings; Dressings, medical; Teeth filling material; Dental impression materials; Disinfectants; Fungicides; Herbicides; Preparations for destroying vermin.

Produits et services

Pharmaceuticals; Veterinary preparations; Sanitary preparations for medical purposes; Foodstuffs and dietetic substances for medical or veterinary purposes; Infant formula; Dietary supplements for humans; Dietary supplements for animals; Plasters, materials for dressings; Dressings, medical; Teeth filling material; Dental impression materials; Disinfectants; Fungicides; Herbicides; Preparations for destroying vermin.

Abrégé

A method for purifying epidaunorubicin is provided. The purification method involves the removal of the impurity epi-feudomycin, which is formed as a by-product in the biotechnological production of epidaunorubicin.

Classes IPC  ?

• C07H 15/252 - Radicaux naphtacène, p. ex. daunomycines, adriamycines
• C07H 1/06 - SéparationPurification
• C07H 15/24 - Systèmes cycliques condensés comportant au moins trois cycles

Abrégé

A transfer device (10) for removing or transferring a medium out of or into a bottle (20) having a bottle neck (34) that can be closed by means of a closure (42), including a first adapter part (12), which can be positioned on the bottle, and a second adapter part (14), which interacts with the first adapter part, which can be displaced in the longitudinal direction of the bottle, and has a conducting element (50) for piercing the closure. After the second adapter part (14) has been displaced along the first adapter part in the direction of the closure (42) and the second adapter part has been locked, the first adapter part (12) is non-releasably fastened to or around the bottle (20).

Classes IPC  ?

• A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques DétailsAccessoires à cet effet
• A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue
• A61J 1/16 - Supports pour récipients

Abrégé

A process is described for the preparation of freeze-dried pharmaceutical compositions of mitomycin C, which are characterized by high stability and can be rapidly reconstituted to form solutions.

Classes IPC  ?

• A61K 31/435 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 31/407 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil condensés avec des systèmes hétérocycliques, p. ex. kétorolac, physostigmine
• A61K 9/08 - Solutions
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine

Produits et services

Pharmaceuticals.

Produits et services

(1) Pharmaceutical preparations for treating cancer and auto-immune diseases; medicines for treating cancer and auto-immune diseases; chemical preparations for medical purposes, namely, chemical reagents for diagnostic purposes; medical plasters; surgical dressings; all purpose disinfectants.

Produits et services

Pharmaceutical preparations; Veterinary preparations; Sanitary preparations for medical purposes; Foodstuffs and dietetic substances for medical or veterinary purposes; Infant formula; Dietary supplements for humans; Dietary supplements for animals; Plasters, materials for dressings; Dressings, medical; Teeth filling material; Dental impression materials; Disinfectants; Fungicides; Herbicides; Preparations for destroying vermin.

Produits et services

Pharmaceutical preparations; Veterinary preparations; Sanitary preparations for medical purposes; Foodstuffs and dietetic substances for medical or veterinary purposes; Infant formula; Dietary supplements for humans; Dietary supplements for animals; Plasters, materials for dressings; Dressings, medical; Teeth filling material; Dental impression materials; Disinfectants; Fungicides; Herbicides; Preparations for destroying vermin.

Abrégé

The present invention relates to a method for purifying epidaunorubicin, in particular to the removal of the impurity epi-feudomycin such as is formed as a by-product in the biotechnological production of epidaunorubicin.

Classes IPC  ?

• C07H 15/24 - Systèmes cycliques condensés comportant au moins trois cycles

Abrégé

The invention relates to a transfer device (10) for removing or transferring a medium out of or into a bottle (20) having a bottle neck (34) that can be closed by means of a closure (42), comprising a first adapter part (12), which can be positioned on the bottle, and a second adapter part (14), which interacts with the first adapter part, can be displaced in the longitudinal direction of the bottle, and has a conducting element (50) for piercing the closure. After the second adapter part (14) has been displaced along the first adapter part in the direction of the closure (42) and the second adapter part has been locked, the first adapter part (12) is non-releasably fastened to or around the bottle (20).

Classes IPC  ?

• A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue

Abrégé

The invention relates to a transfer device (10) for removing or transferring a medium out of or into a bottle (20) having a bottle neck (34) that can be closed by means of a closure (42), comprising a first adapter part (12), which can be positioned on the bottle, and a second adapter part (14), which interacts with the first adapter part, can be displaced in the longitudinal direction of the bottle, and has a conducting element (50) for piercing the closure. After the second adapter part (14) has been displaced along the first adapter part in the direction of the closure (42) and the second adapter part has been locked, the first adapter part (12) is non-releasably fastened to or around the bottle (20).

Classes IPC  ?

• A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue

Abrégé

The invention relates to a transfer device for tapping or delivering a fluid from a bottle sealed with a closure, the device having a hollow cylinder-shaped first part having a circumferential wall, which first part can be placed on the bottle and surrounds the closure, a hollow cylinder-shaped second part which can be adjusted with respect to the first part, the second part having a first wall running transverse to the longitudinal axis direction, and a puncturing needle originating from the first wall and extending in the direction of the first part permitting piercing of the closure, wherein the first part cannot be adjusted axially with respect to the second part if the closure is not surrounded and, if the first part surrounds the closure, the first part can be adjusted with respect to the second part for piercing the closure.

Classes IPC  ?

• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
• A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue
• A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques DétailsAccessoires à cet effet

Produits et services

Pharmaceutical preparations for treating autoimmune diseases and oncological diseases.

Abrégé

The invention relates to a method for producing freeze-dried mitomycin C compositions which have excellent stability and can be quickly reconstituted to solutions.

Classes IPC  ?

• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 9/08 - Solutions
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques

Abrégé

5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4′-epidaunorubicin hydrochloride than solvent B. A method of producing an anthracycline using crystalline 4′-epidaunorubicin hydrochloride is also provided.

Classes IPC  ?

• C07H 15/24 - Systèmes cycliques condensés comportant au moins trois cycles
• C07H 15/252 - Radicaux naphtacène, p. ex. daunomycines, adriamycines
• C07H 1/00 - Procédés de préparation des dérivés du sucre

Produits et services

Computer software; Interactive computer systems. Educational instruction. Advisory services relating to computer programming; Computer software research; Developing computer software; Computer programming and software design. Medical services; Medical advisory services; Medical services for the diagnosis of conditions of the human body; Counselling relating to the social relief of medical ailments; Professional consultancy relating to health care; Monitoring of patients; Providing health care information by telephone; Professional consultancy relating to health; Advisory services relating to health; Mental health services.

Produits et services

Pharmaceutical preparations.

Abrégé

The present invention relates to a pharmaceutical composition according to the invention containing 14 to 17.5 mg leflunomide prepared as a single dose and uses thereof.

Classes IPC  ?

• A61K 31/42 - Oxazoles
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe

Abrégé

5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4′-epidaunorubicin hydrochloride than solvent B. A method of producing an anthracycline using crystalline 4′-epidaunorubicin hydrochloride is also provided.

Classes IPC  ?

• C07H 15/24 - Systèmes cycliques condensés comportant au moins trois cycles

Produits et services

Pharmaceutical preparations.

Abrégé

The invention relates to a transfer device (10) for tapping or delivering a fluid from a bottle (24) sealed with a closure (26, 28), said device comprising a hollow cylinder-shaped first part (12) having a circumferential wall (16), which first part (12) can be placed on the bottle and surrounds the closure (26, 28), a hollow cylinder-shaped second part (14) which can be adjusted with respect to the first part (12), said second part having a first wall (46) running transverse to the longitudinal axis direction, and a puncturing needle (48) originating from the first wall (46) and extending in the direction of the first part permitting piercing of the closure (26, 28), wherein the first part (12) cannot be adjusted axially with respect to the second part if the closure (26, 28) is not surrounded and, if the first part (12) surrounds the closure (26 28), the first part (12) can be adjusted with respect to the second part (14) for piercing the closure (26, 28). To prevent any injury from the puncturing needle (48), according to the invention the first part (12) has a second wall (30) running transverse to the longitudinal axis (80) of the first part (12) and the distal end (74) of the puncturing needle (48) runs between the first and the second wall (30, 46) if the first and the second parts (12, 14) cannot be axially adjusted or largely cannot be axially adjusted with respect to one another.

Classes IPC  ?

• A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue

Produits et services

Pharmaceutical preparations.

Produits et services

Pharmaceutical preparations.

Abrégé

A crystalline epirubicin hydrochloride and a method for its production are provided. The method for producing the crystalline epirubicin hydrochloride includes the steps: (a) providing epirubicin hydrochloride, (b) producing a mixture containing the provided epirubicin hydrochloride and at least one alcohol selected from the group 1-butanol, 2-butanol, and 1-pentanol, and (c) crystallizing epirubicin hydrochloride from this mixture.

Classes IPC  ?

• C07H 15/252 - Radicaux naphtacène, p. ex. daunomycines, adriamycines
• C07H 1/06 - SéparationPurification

Abrégé

5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4′-epidaunorubicin hydrochloride than solvent B.

Classes IPC  ?

• C07D 315/00 - Composés hétérocycliques contenant des cycles comportant un atome d'oxygène comme unique hétéro-atome du cycle, couverts par plus d'un des groupes principaux

Produits et services

(1) Medicines, namely antirheumatics.

Produits et services

Pharmaceutical preparations, medicines, chemical preparations for medical purposes, plasters, surgical dressing; disinfectants.

Produits et services

Pharmaceutical preparations, Medicines, Chemicals for medical use, Plasters, Materials for dressings; Disinfectants.

Abrégé

The present invention relates to a form of crystalline 4'-epidaunorubicin hydrochloride which is stable and readily soluble, and to a process for the production thereof. This process comprises crystallizing 4'-epidaunorubicin hydrochloride in a solvent system including (a) solvent A which is selected from the group consisting of Cl and C2 halogenated solvents and mixtures thereof, (b) solvent B which is selected from the group consisting of Cl - C5 straight and branched alcohols and mixtures thereof, and (c) solvent C which is selected from the group consisting of Cl - C5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4'-epidaunorubicin hydrochloride than solvent B.

Classes IPC  ?

• C07H 15/24 - Systèmes cycliques condensés comportant au moins trois cycles

Produits et services

Pharmaceutical preparations.

Produits et services

Pharmaceutical preparations.

Produits et services

Pharmaceutical preparations.

Produits et services

Contract manufacturing of pharmaceutical preparations, for others.

Produits et services

Medicines.

Produits et services

Pharmaceutical products.

Produits et services

Medicines, namely antirheumatics.

Produits et services

Medicines, namely antirheumatics.

Abrégé

The invention relates to methotrexate derivatives which contain a protein-binding group and can be enzymatically split in the body such that the active substance or a low-molecular active substance derivative is released. Also disclosed is a method for producing methotrexate derivatives, the use thereof, and medicaments comprising methotrexate derivatives.

Classes IPC  ?

• C07K 5/10 - Tétrapeptides
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament

Abrégé

The invention relates to concentrated methotrexate solutions containing an active substance for the production of a parenterally administered medicament for the treatment of inflammatory autoimmune diseases. The methotrexate is added to a pharmaceutically compatible solvent, in a concentration of more than 25mg/ml. The invention also relates to a ready-made syringe, a carpule containing such a pharmaceutical solution formulation, and a pen injector comprising such a carpule and/or a ready-made syringe.

Classes IPC  ?

• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61P 11/06 - Antiasthmatiques
• A61P 17/06 - Antipsoriasiques
• A61P 19/00 - Médicaments pour le traitement des troubles du squelette
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Produits et services

(1) Pharmaceutical preparations for treating cancer and autoimmune diseases.

Produits et services

Pharmaceuticals.

Produits et services

Pharmaceutical products.

Produits et services

(1) Pharmaceutical and veterinary preparations for treating cancers and autoimmune diseases; preparations for detecting cancers and autoimmune diseases; food for babies; material for stopping teeth, dental wax; preparations for destroying vermin; fungicides, herbicides.