The present invention relates to novel antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of detecting VISTA.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
4.
METHOD AND SYSTEM FOR ASSISTING A USER IN GUIDING A CATHETER DURING A CARDIAL OPERATION
A method, apparatus and computer program product, the method comprising: obtaining electrical information from a plurality of electrodes disposed on a distal end assembly of a catheter within a heart of a patient as the catheter is being maneuvered within the heart; dynamically identifying a portion of the distal end assembly that is displaced from tissue wall of the heart, based upon the electrical information received from the plurality of electrodes; generating a visual representation of the distal end assembly; dynamically distorting the visual representation by warping (the identified portion of the distal end assembly; and rendering the visual representation as dynamically distorted to the display device.
A61B 5/343 - Indication de la répartition des potentiels électriques
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/0538 - Mesure de l'impédance ou de la conductivité électrique d'une partie du corps invasive, p. ex. en utilisant un cathéter
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
A61B 5/287 - Supports pour électrodes multiples, p. ex. cathéters à électrode pour des études électrophysiologiques [EEP]
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A method includes receiving an anatomical map of wall tissue of at least a portion of a cardiac chamber, the map superimposed with a grid of ablation tags that are graphically encoded according to respective levels of ablation of the wall tissue. Upon placing a multi-electrode ablation catheter in a vicinity of the wall tissue, one or more of the ablation tags are graphically re-encoded according to (i) existing levels of ablation associated with the tags and (ii) electrode proximity to wall tissue locations associated with the tags. The anatomical map, having the re-encoded ablation tags, is displated to a user.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A catheter apparatus, including an elongated deflectable element, a distal assembly, a force sensor disposed between the elongated deflectable element and the distal assembly, and comprising a spring including a tube with at least one helical cut extending around a circumference of the tube, the at least one helical cut including deviations extending in a longitudinal direction of the tube, the deviations being configured to prevent overstretching and overbending of the spring.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A method for producing a surgical instrument is disclosed. The method comprises obtaining a handle, wherein the handle comprises a distal end comprising a shaft interface surface and a first set of magnetic elements. The method further comprises obtaining a shaft, wherein the shaft comprises a proximal end comprising a handle interface surface, a second set of magnetic elements, and a third set of magnetic elements. The method further comprises attaching the shaft to the handle, wherein the shaft interface surface is configured to engage the shaft at the handle interface surface, wherein an attractive magnetic force is configured to pull the handle towards the shaft when the first set of magnetic elements interact with the second magnetic elements, and wherein a repulsive magnetic force is configured to repel the handle from the shaft when the first set of magnetic elements interacts with the third set of magnetic elements.
A61B 17/10 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour poser ou retirer les clamps pour blessuresChargeurs de clamps pour blessures
A61B 17/115 - Agrafeuses pour réaliser une anastomose, p. ex. en une seule opération
A61B 17/122 - Clamps ou pinces, p. ex. pour le cordon ombilical
A61B 17/128 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical pour appliquer ou enlever les clamps ou les pinces
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
A61B 90/90 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes
A61B 90/96 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes utilisant des symboles, p. ex. du texte utilisant des codes-barres
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes utilisant des moyens électromagnétiques, p. ex. transpondeurs
G16H 40/00 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux
The present invention is directed to a surgical instrument with a robotics system, a memory device and an end effector having an elongate channel, knife position sensor(s) and a firing bar coupled to a knife. In response to drive motions initiated by the robotics system, the firing bar may translate within the elongate channel. As the firing bar translates, the sensor(s) transmit a signal to the memory device. The position of the knife may be determined from the output signals and may be communicated to the robotics system or instrument user. The sensors may be Hall Effect sensors.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/072 - Agrafeuses chirurgicales pour appliquer une rangée d'agrafes en une seule opération, p. ex. agrafes appliquées simultanément
A61B 17/10 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour poser ou retirer les clamps pour blessuresChargeurs de clamps pour blessures
A61B 17/29 - Pinces pour la chirurgie faiblement invasive
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
9.
Methods for Controlling Cooperative Surgical Instruments
Systems, devices, and methods for controlling cooperative surgical instruments are provided. Various aspects of the present disclosure provide for coordinated operation of surgical instruments accessing a common body cavity of a patient from different approaches to achieve a common surgical purpose. For example, various methods, devices, and systems disclosed herein can enable the coordinated treatment of surgical tissue by disparate minimally invasive surgical systems that approach the tissue from varying anatomical spaces and operate in concert with one another to effect a desired surgical treatment.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
A61B 1/313 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour l'introduction dans des incisions chirurgicales, p. ex. laparoscopes
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour réaliser l'anastomoseBoutons pour anastomose
A61B 17/115 - Agrafeuses pour réaliser une anastomose, p. ex. en une seule opération
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
Various embodiments of surgical robot control systems are disclosed. In one example embodiment, the surgical robot control system comprises a housing. A controller is located within the housing and is coupled to a socket. The socket receives a handheld surgical user interface therein to control a surgical instrument. The surgical instrument is connected to the surgical robot and comprises an end effector and a mechanical interface to manipulate the end effector. The mechanical interface is coupled to the controller. At least one sensor is coupled to the controller and the socket to convert movement of the handheld surgical user interface into electrical signals corresponding to the movement of the surgical instrument. At least one feedback device is coupled to the controller to provide feedback to a user. The feedback is associated with a predetermined function of the surgical instrument.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A luer fitting that included a body having a proximal region, a distal region, and a length therebetween. The body includes: a recessed region within a portion of the length of the body at the proximal region, the recessed region having a proximal end opening, an inner back wall and an inner circumferential sidewall; a barb extending proximally from the inner back wall; and a passage between a first opening at the distal region of the body to a second opening at a proximal end of the barb, the passage forming an inner surface and having a first inner diameter at or near the first opening at the distal region opening that is greater than a second inner diameter at or near the inner back wall of the recessed region, wherein the transition between the first inner diameter and the second inner diameter is curvilinear.
An apparatus includes a first jaw member including a first needle clamp pad and a first suture clamp pad. The apparatus also includes a second jaw member including a second needle clamp pad and a second suture clamp pad. The first and second jaw members are pivotable relative to each other between an open state, a first closed state in which the first and second suture clamp pads are configured to cooperate with each other to securely grip a suture, and a second closed state in which the first and second needle clamp pads are configured to cooperate with each other to securely grip a needle.
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour la suture des plaiesSupports ou emballages pour aiguilles ou matériaux de suture
A61B 17/062 - Dispositifs pour manipuler les aiguilles
A method includes, receiving: (i) a selected three-dimensional (3D) section that has been ablated in a patient organ in accordance with a specified contour, and (ii) a dataset, which is indicative of a set of lesions formed during ablation of the selected 3D section. The selected 3D section is transformed into a two-dimensional (2D) map, and checking, on the 2D map, whether the set of lesions covers the specified contour.
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
A surgical stapler includes a first elongate member having a distal portion that supports an anvil surface, and a second elongate member having a distal portion configured to receive a staple cartridge. The stapler further includes a pin rotatably coupled with the first elongate member, and a clamp member movably coupled with the second elongate member. The clamp member is operable to releasably capture the pin to thereby clamp the first elongate member against the second elongate member. The pin is configured to rotate relative to the first elongate member in response to being captured by the clamp member.
An apparatus includes a first jaw member including a first needle clamp pad and a first suture clamp pad. The apparatus also includes a second jaw member including a second needle clamp pad and a second suture clamp pad. The first and second jaw members are pivotable relative to each other between an open state, a first closed state in which the first and second suture clamp pads are configured to cooperate with each other to securely grip a suture, and a second closed state in which the first and second needle clamp pads are configured to cooperate with each other to securely grip a needle.
A luer fitting that included a body having a proximal region, a distal region, and a length therebetween. The body includes: a recessed region within a portion of the length of the body at the proximal region, the recessed region having a proximal end opening, an inner back wall and an inner circumferential sidewall; a barb extending proximally from the inner back wall; and a passage between a first opening at the distal region of the body to a second opening at a proximal end of the barb, the passage forming an inner surface and having a first inner diameter at or near the first opening at the distal region opening that is greater than a second inner diameter at or near the inner back wall of the recessed region, wherein the transition between the first inner diameter and the second inner diameter is curvilinear.
A staple cartridge including: a cartridge body; a staple pocket in the cartridge body, the staple pocket having an opening and containing an unformed staple including a first leg and a second leg, the staple pocket containing the first leg and the second leg of the unformed staple in an unfired position; and two or more guide surfaces in the staple pocket disposed adjacent the opening, wherein the guide surfaces are configured to deform the first leg of the unformed staple as the first leg exits the staple pocket at the opening during a firing of the unformed staple.
The disclosed technology includes a sterilizable powered electronics system for a surgical instrument that includes a boost regulator circuit, an ultracapacitor, and a sealed enclosure. The boost regulator circuit is configured to electrically connect to one or more batteries and output at least one of a predetermined voltage or a predetermined current. The ultracapacitor is electrically connected to the boost regulator circuit. The sealed enclosure encloses the boost regulator circuit and is configured to withstand temperatures greater than 50° C. and pressures greater than 15 psi. At least one of the boost regulator circuit or the ultracapacitor can be configured to be electrically connected to an instrument motor.
H02P 23/00 - Dispositions ou procédés pour la commande de moteurs à courant alternatif caractérisés par un procédé de commande autre que la commande par vecteur
A surgical instrument includes an end effector, a shaft assembly, and an axial location feature. The end effector includes an ultrasonic blade and a clamp arm that can move between an open and closed position. The shaft assembly includes a proximal shaft portion, an acoustic waveguide extending proximally from the ultrasonic blade, a distal shaft portion extending along a distal axis, and an articulation section interposed between the proximal shaft portion and the distal shaft portion. The articulation section can deflect the distal shaft portion and the end effector relative to the longitudinal axis between a non-deflected position and a deflected position. The axial location feature can inhibit the ultrasonic blade from shifting relative to the clamp arm along the distal axis as the end effector is driven between the non-deflected position and the deflected position.
A depth limiter that is configured to couple with first and second trocar cannulas having different diameters. The depth limiter includes first and second body portions. First and second body portions each include first and second gripping surfaces. The first and second body portions are pivotably coupled together and are movable between an open configuration and a closed configuration. In the open configuration, the first and second body portions are configured to allow for axial movement of the depth limiter relative to the first and second trocar cannulas. The first gripping surfaces of the first and second body portions are configured to restrict axial movement of the depth limiter relative to the first trocar cannula in the closed configuration. The second gripping surfaces of the first and second body portions are configured to restrict axial movement of the depth limiter relative to the second trocar cannula in the closed configuration.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate or enhance or mimic VISTA's suppressive effects on T cell immunity and thereby suppress T cell immunity. These agonist antibodies and antibody fragments are especially useful in the treatment of autoimmunity, allergy, inflammatory conditions, GVHD, sepsis and transplant recipients. Screening assays for identifying these agonists are also provided.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
An orthopaedic surgical instrument may include an elongated body with a broach end and an impactor end. The body may be straight or curved. A latch lever may be pivotally coupled to the elongated body. The latch lever may be moveable between an open position and a latched position in which the latch lever is retained within the body. A surgical broach may be rigidly attached to the broach end of the elongated body. An automated surgical impactor may be attached to the impactor end.
A system includes an input device and a processor. The processor is configured to (i) one of receive and generate an electrophysiological (EP) map that visualizes a first EP parameter on the EP map with a graphical representation that varies in size according to a value of the first EP parameter, (ii) receive, using the input device, a second EP parameter, (iii) apply a visual indication of the second EP parameter on the graphical representation of the first EP parameter, wherein the visual indication varies according to a value of the second EP parameter, and (iv) display the EP map to the user on a display device.
A system included an input device and a processor. The processor is configured to (i) receive or generate an electrophysiological (EP) map comprising one or more regions of interest (ROIs), (ii) receive from a user, via the input device, a level of deemphasis the EP map required outside the ROIs, (iii) deemphasize the EP map outside the ROIs responsively to the required level, and (iv) display the deemphasized EP map to the user.
The present invention concerns pharmaceutical formulations of apalutamide, which can be administered to a mammal, in particular a human, suffering from an androgen receptor (AR)-related disease or condition, in particular cancer, more in particular prostate cancer.
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
Provided herein are small interfering ribonucleic acid (siRNA) agents targeting a microtubule-associated protein tau (MAPT) gene and compositions comprising such siRNA agents.
A method includes applying pacing to ventricle of heart of patient from multiple electrode locations over circumference of multi-electrode catheter area. Cardiac signals are received in response to the pacing. A correlation algorithm is applied to the received signals to calculate a plurality of correlations among the received signals. Based on calculated correlations, the area is checked if it includes an arrhythmogenic location identified with predefined sufficient spatial resolution. If the resolution is insufficient, sub-area to pace is defined. Subsequent pacing is applied to ventricle from multiple electrode locations over a circumference of the sub-area. Subsequent cardiac signals are received in response to the subsequent pacing. Subsequent correlations among the subsequent received signals are calculated. Based on the subsequent correlations, it is ascertained whether the arrhythmogenic location is found in the sub-area. If an arrhythmogenic location is found with sufficient spatial resolution, the identified arrhythmogenic location is indicated to user.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/257 - Moyens adhésifs, p. ex. garnitures ou bandes adhésives
A61B 5/287 - Supports pour électrodes multiples, p. ex. cathéters à électrode pour des études électrophysiologiques [EEP]
A61B 5/339 - Affichages spécialement adaptés à cet effet
A61B 5/363 - Détection de la tachycardie ou de la bradycardie
A61B 5/364 - Détection d'intervalle ECG anormal, p. ex. des extrasystoles ou des battements cardiaques ectopiques
33.
REDUCING NOISE OF INTRACARDIAC ELECTROCARDIOGRAMS USING AN AUTOENCODER AND UTILIZING AND REFINING INTRACARDIAC AND BODY SURFACE ELECTROCARDIOGRAMS USING DEEP LEARNING TRAINING LOSS FUNCTIONS
A system and method include a memory storing processor executable code for a denoised autoencoder, and one or more processors coupled to the memory to execute the processor executable code to receive raw signal data comprising signal noise, encode, by the denoised autoencoder, the raw signal data by performing a denoising autoencoder operation to produce a latent representation, and decode, by the denoised autoencoder, the latent representation to produce clean signal data reconstructed without the signal noise. A first filter is applied to a signal to emphasize activity within the signal and to produce a first modified signal, a rectifier and a second filter are applied to the first modified signal to smooth areas of the first modified signal with clinical importance and to produce a second modified signal, and high frequency energy zones of the second modified signal are automatically detected using an energy threshold to produce a weights vector.
In one embodiment, a system includes a balloon catheter configured to be inserted into a body-part of a living subject, the balloon catheter comprising an insertion tube having a distal tip, a force sensor connected to the distal tip, and an inflatable balloon including a proximal portion connected to the force sensor so that the force sensor is disposed between the distal tip of the insertion tube and the inflatable balloon, and multiple electrodes disposed around an outer surface of the balloon, and configured, when the balloon is inflated, to contact tissue at respective locations in the body-part, wherein the force sensor is configured to output at least one force signal indicative of a magnitude and a direction of a force applied by the balloon on the tissue when the balloon is inflated.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
Systems, methods and devices for surgical procedurelization via a modular energy system are disclosed herein. In various aspects, the systems, methods and devices include an energy module, a header module communicably coupled to the energy module, and a display screen capable of rendering a graphical user interface (GUI). The GUI may be configured to display a plurality of steps that correspond with actions performed by a user while operating the modular energy system. In some aspects, the steps displayed are steps of a predetermined procedural checklist corresponding with a mental model followed by the user while performing a surgical procedure. In some aspects, the steps displayed are steps of an output verification process.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
36.
ADJUSTMENT OF A SURGICAL DEVICE FUNCTION BASED ON SITUATIONAL AWARENESS
Surgical devices and surgical systems are disclosed. The surgical device can comprise an actuator and a control circuit configured to adjust one or more functions of the surgical device based on a signal from a situationally-aware surgical hub. A surgical system can comprise a screen and a control circuit configured to communicate a priority level of a recommendation to the clinician on the display.
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 34/35 - Robots chirurgicaux pour la téléchirurgie
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
G01N 15/06 - Recherche de la concentration des suspensions de particules
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
37.
MYOPIC CONTROL PROGRESSION MODELING, TRACKING, AND/OR TREATMENT
Myopic control progression modeling, tracking, and/or treatment is disclosed. The myopic control progression tracking uses a synthesized myopic progression modeling employing an initial efficacy boost in myopic progression of the patient's eye. Methods and apparatuses for determining myopic control treatment efficacy in a myopic control treated patient using synthesized myopic progression modeling employing using an "untreated" predicted myopic control progression data for the respective patient group(s) but then altered with (1) application of observed initial boost in efficacy; (2) an expected consistent reduction per year in axial elongation subsequent; and (3) an accumulated multi-year (e.g. three year) reduction of axial elongation. In this manner, "treated" predicted myopic control progression models can be generated that can be used to determine whether the actual efficacy of the myopia control intervention treatment in the patient's eye is consistent with an accurate predicted efficacy of the myopia control intervention treatment.
G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
The disclosure provided herein relates to methods of enriching cells expressing a chimeric antigen receptor (CAR) transgene comprising a BIRD linker peptide. In particular, the disclosure provided herein relates to methods of using antibodies that bind to the BIRD linker peptide to enrich CAR+ cells.
A staple cartridge assembly for use with a surgical stapling instrument is disclosed. The staple cartridge assembly comprises an elongated channel comprising a retaining feature and a staple cartridge insertable into the elongated channel. The staple cartridge includes a deck defining a tissue contacting surface, a housing, a cartridge pan releasably attachable to the elongated channel, staple drivers stored in the housing between the deck and the cartridge pan, staples stored in the housing, a central longitudinal slot along a central longitudinal plane, and a sled translatable relative to the cartridge pan from a first position toward a second position to motivate the staple drivers to deploy the staples. The retaining feature is configured to resist a movement of the sled beyond the first position up to a predetermined force. The retaining feature extends across the central longitudinal slot.
The present invention relates to improved contact lens packages. The package may be configured such that upon opening the package by a wearer the packaging solution drains away from the contact lens and is substantially recaptured in the lid. Lens packages also may include a lens support that facilitates single touch transfer or a colored region that visually indicates to a wearer where to hold the package for opening.
A method includes emitting an ultrasound beam from an array of ultrasound transducers in a catheter placed in a blood pool in an organ. Echo signals reflected in response to the ultrasound beam are received in the array. Distinction is made in the echo signals between (i) first spectral signal components having Doppler shifts characteristic of blood and (ii) second spectral signal components having Doppler shifts characteristic of tissue of the organ. The first spectral signal components are suppressed relative to the second spectral signal components in the echo signals. An ultrasound image of at least a portion of the organ is reconstructed from the echo signals having the suppressed first spectral signal components. The reconstructed image is displayed to a user.
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
44.
Safe and Effective Method of Treating Psoriatic Arthritis with Anti-IL23 Specific Antibody
A method of treating psoriatic arthritis in a patient by administering an IL-23 specific antibody, e.g., guselkumab, in a clinically proven safe and clinically proven effective amount and the patient achieves significant ACR20/50/70, PASI70/90/100, MDA, HAQ-DI, SF-36 PCS, MCS, LEI/dactylitis, PASDAS, GRACE, mCPDAI, DAPSA or RAPID3 improvement as measured 16, 24, 32, 40 and 48 weeks after initial treatment.
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
45.
METHODS FOR TREATING MULTIPLE MYELOMA WITH CAR-T CELLS AND BISPECIFIC ANTIBODIES
Provided herein are methods of treating cancer in a subject in need thereof. In some embodiments, the method comprises administering an anti-BCMA CAR-T cell and a GPRC5DxCD3 bispecific antibody. In some embodiments, the method comprises administering an anti-BMCA CAR-T cell, a GPRC5DxCD3 bispecific antibody, and a BCMAxCD3 bispecific antibody.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 40/11 - Lymphocytes T, p. ex. lymphocytes infiltrant les tumeurs [TIL] ou lymphocytes T régulateurs [Treg]Cellules tueuses activées par les lymphokines [LAK]
Provided herein are methods of treating cancer in a subject in need thereof by administering an anti-BCMA CAR-T cell and a GPRC5DxCD3 bispecific antibody. In some embodiments, the subject has relapsed and/or refractory multiple myeloma. In some embodiments, the subject has received at least one prior line of therapy. In some embodiments, the subject has newly diagnosed multiple myeloma and is transplant ineligible.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 40/11 - Lymphocytes T, p. ex. lymphocytes infiltrant les tumeurs [TIL] ou lymphocytes T régulateurs [Treg]Cellules tueuses activées par les lymphokines [LAK]
An apparatus (1000) includes an end effector (1200, 2200, 2300, 3200, 4200, 5200), a first flexible coil (508, 1508), a second flexible coil (510, 1510), and a pivoting lock (1270, 2270, 2370, 3270, 4270, 5270). The end effector includes a first jaw (1202, 2202, 2302, 3202, 4202, 5202), a second jaw (1202), and a knife (1206, 2206, 2306, 3206, 4206, 5206). The first and second flexible coils are operatively attached to an upper portion (1238, 2238, 2338, 3238, 4238, 5238) and a lower portion (1246, 2246, 2346, 3246, 4246, 5246) of the knife, respectively. The pivoting lock is pivotable from an unlocked configuration to a locked-out configuration about a pivot axis located vertically between the first and second flexible coils to inhibit distal actuation of the knife. The knife can move the pivoting lock relative to the first and second jaws along the firing stroke.
An end effector of a surgical instrument may be equipped with a firing redirect assembly including: a firing carrier; a reaction pulley disposed distally from the firing carrier; a firing cable coupled to a distal end of the firing carrier and wrapping around the reaction pulley and extending proximally past the firing carrier; and a reaction cable coupled to and extending between a distal end of the reaction pulley and a proximal end of an end effector of the surgical tool, the end effector including a cartridge jaw and an anvil jaw pivotably connected to the cartridge jaw at a pivot, where a firing load on the firing cable in a proximal direction causes the firing carrier to translate distally and causes the reaction pulley and the reaction cable to translate proximally, thereby assisting with closing the anvil jaw or assisting with stabilizing an articulation joint of the end effector.
Provided herein are methods of treating a subject who has multiple myeloma and has received one to three prior treatment(s). Infusions of chimeric antigen receptor (CAR)-T cells comprising a CAR capable of specifically binding to an epitope of BCMA are administered to the subject.
A61K 40/11 - Lymphocytes T, p. ex. lymphocytes infiltrant les tumeurs [TIL] ou lymphocytes T régulateurs [Treg]Cellules tueuses activées par les lymphokines [LAK]
A medical probe includes a shaft and a distal-end assembly. The shaft is configured for insertion into an organ of a body. The distal-end assembly is fitted at a distal end of the shaft. The distal-end assembly includes (a) a substrate, (b) a two-dimensional (2D) ultrasound transducer array located on the substrate, and (c) a sensor, which is also located on the substrate, the sensor configured to output signals indicative of a position and an orientation of the 2D ultrasound transducer array inside the organ.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
G01R 35/00 - Test ou étalonnage des appareils couverts par les autres groupes de la présente sous-classe
G01S 7/52 - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
G01S 15/89 - Systèmes sonar, spécialement adaptés à des applications spécifiques pour la cartographie ou la représentation
51.
ELECTRO-ANATOMICAL MAPPING AND ANNOTATION PRESENTED IN ELECTROPHYSIOLOGICAL PROCEDURES
A catheter includes: (a) a shaft for insertion into a heart of a patient, (b) an expandable distal-end assembly, which is coupled to the shaft and is configured to make contact with tissue of the heart, (c) at least first and second electrocardiogram (ECG) electrodes, which are coupled to an outer surface of the expandable distal-end assembly, and when placed in contact with the tissue, are configured to sense ECG signals in the tissue, and (d) a reference electrode, which is positioned within an inner volume of the distal-end assembly, and in an expanded position of the distal-end assembly, the reference electrode: (i) has no physical contact with the tissue, and (ii) is positioned at a first distance from the first ECG electrode and at a second distance from the second ECG electrode, and the difference between the first and second distances is smaller than a predefined threshold.
Provided is a serum-free, xeno-free, feeder-free method for selectively activating and expanding human γδ T cells to achieve sufficient cell numbers for adoptive cell therapy while retaining their robust intrinsic antitumor activity comprising: (a) contacting the γδ T cells with an isolated antibody or antigen-binding fragment that agonizes the γδ T cell receptor; (b) culturing the γδ T cells in cell culture medium comprising a cytokine selected from IL-2, IL-7, IL-12, IL-15, IL-18, IL-21, IL-22, IL-27, and TGFβ, and combinations thereof; wherein the cell culture medium further comprises a serum substitute In some embodiments, the γδ T cells are obtained from induced pluripotent stem cells (iPSCs) and/or peripheral blood mononuclear cells (PBMCs). In further embodiments, the γδ T cells express the Vγ9Vδ2 T cell receptor. The iPSC-derived γδ T cells or the PBMC-derived γδ T cells may be engineered to express a chimeric antigen receptor (CAR).
A processing system automatically detects regions of GA-related biomarkers from medical images. The processing system obtains a volumetric image of an eye comprising a set of image slices. For each of the image slices, the processing system applies a machine learning model to generate likelihood values characterizing inferred regions of GA-related biomarkers. The machine learning model is trained to learn relationships between training image slices from training volumetric images and labels identifying regions of GA-related biomarkers in the training volumetric images. The processing system generates from the likelihood values, an inference map that spatially maps the inferred regions of the GA-related biomarkers. The processing system furthermore outputs a visual representation of the inference map, such as a two dimensional enface map or a three-dimensional map, to a display device.
An apparatus (1000) includes a shaft (600A) and an end effector (1200, 2200) configured to receive a staple cartridge (210) having staples and a sled (1210a, 2210a). The end effector includes a knife (1206, 2206), an anvil jaw (204, 1204), a cartridge jaw (1208, 2208), and a blocker (1255, 2255) coupled to the cartridge jaw. The blocker is vertically translatable relative to the cartridge jaw and the knife between a raised and lowered positions. The blocker in the raised position is configured to directly contact and thereby inhibit distal advancement of the knife, and the blocker in the lowered position is configured to permit distal advancement of the. The blocker is configured to assume the raised position in the absence of an unspent staple cartridge and the lowered position in the presence of an unspent staple cartridge.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/02 - Instruments, dispositifs ou procédés chirurgicaux pour maintenir les blessures ouvertes, p. ex. rétracteursÉcarteurs
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour la suture des plaiesSupports ou emballages pour aiguilles ou matériaux de suture
A61B 17/06 - AiguillesSupports ou empaquetages pour aiguilles ou matériaux de suture
A61B 17/062 - Dispositifs pour manipuler les aiguilles
A61B 17/10 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour poser ou retirer les clamps pour blessuresChargeurs de clamps pour blessures
A61B 17/115 - Agrafeuses pour réaliser une anastomose, p. ex. en une seule opération
A61B 17/122 - Clamps ou pinces, p. ex. pour le cordon ombilical
A61B 17/128 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical pour appliquer ou enlever les clamps ou les pinces
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 90/53 - Supports pour instruments chirurgicaux, p. ex. bras articulés reliés au corps du chirurgien, p. ex. par une ceinture
A61B 90/90 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes
A61B 90/92 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes utilisant des codes de couleurs
A61B 90/96 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes utilisant des symboles, p. ex. du texte utilisant des codes-barres
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes utilisant des moyens électromagnétiques, p. ex. transpondeurs
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
H03K 17/95 - Commutateurs de proximité utilisant un détecteur magnétique
H03K 17/955 - Commutateurs de proximité utilisant un détecteur capacitif
Disclosed herein are methods for analyzing predictors including quantitative values of biomarkers (e.g., metabolite biomarkers) for predicting risk of cancer in a human subject. Further disclosed herein are kits for measuring quantitative values of the markers as well as computer systems and software embodiments for predicting risk of cancer in a human subject based on the quantitative values of the biomarkers (e.g., metabolite biomarkers).
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
The present invention provides methods of maintaining stable remission or stable response achieved by a patient with depression following administration of a therapeutically effective amount of esketamine during an initial administration phase, comprising continuing administration of a therapeutically effective amount of esketamine for at least five months during a subsequent administration phase. The present invention also provides methods for the long term treatment of depression in a patient, comprising administering to the patient in need of the treatment a clinically proven safe and clinically proven effective therapeutically effective amount of esketamine for at least six months. In some embodiments, the depression is major depressive disorder or treatment resistant depression.
Materials, methods, and systems for the cellular redifferentiation and expansion of induced pluripotent stem cell (iPSC)-derived hematopoietic stem cells (iHSCs) without the use of serum or additional cells is provided.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
60.
CELL MANUFACTURING MANAGEMENT PLATFORM USING MACHINE LEARNING
A cell manufacturing management platform facilitates management of a cell manufacturing process. The cell manufacturing management platform tracks events associated with a cell manufacturing process and coordinates between disparate entities involved in the process. The cell manufacturing management platform utilizes machine learning techniques to generate inferences associated with event scheduling in a manner that optimizes an efficiency metric and reduces likelihood of exceptions occurring. Machine learning models may furthermore be used to generate various alerts or other actions associated with the process. A user interface enables different participating entities to track progress of the process and upcoming events.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
61.
METHOD, COMPUTING DEVICE AND SURGICAL SYSTEM FOR AUTOMATICALLY EDITING SURGICAL VIDEO
The present invention provides a method for automatically editing a surgical video, comprising: receiving a raw surgical video captured by an image capture device; pre-processing the raw surgical video; performing machine learning analysis on each video frame of a plurality of video frames, to identify a surgical scene; performing labeling on the surgical video at least once according to the result of the identification for each video frame; determining retention or deletion of each time period according to the result of the labeling; generating and exporting an edited surgical video on the basis of retained time periods; storing the edited surgical video; and displaying the edited surgical video. The present invention further provides a computing device capable of implementing the method, a computer-readable medium, and a surgical system comprising the computing device. The method according to the present invention can automatically identify, label, and retain important segments in a surgical video, and eliminate unimportant segments, so as to automatically obtain a surgical video on which different amounts of clipping can be performed according to a user's choice.
The present invention provides a surgical stapler. The surgical stapler includes an anvil portion, the anvil portion including a cap portion at one end of an anvil portion body, and a retaining pin recess of the anvil portion being offset to one side relative to a center line. An extension section of the cap portion provides a part of a tissue contacting surface of the anvil portion or is used for supporting a widened tissue contacting surface. This configuration allows as much as possible for a certain error when firing a retaining pin, so that even if the retaining pin is not accurately received by the retaining pin recess, an end portion of the retaining pin will abut against the tissue contacting surface of the anvil portion without missing the anvil portion and entering tissue. The retaining pin abuts against the enlarged tissue contacting surface, thereby resisting actuation of the anvil portion and a staple cartridge toward a closed configuration, which can enable an operator to perceive abnormal actuation of a guide pin. In addition, the retaining pin abutting against the tissue contacting surface of the anvil portion may be returned to the retaining pin recess with subsequent slight shaking or a similar operation, to allow for subsequent surgical procedures.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
63.
METHODS AND SYSTEMS FOR MICROBIAL DETECTION USING RAMAN AND INFRARED SPECTROSCOPY
Provided is a method for detecting a microbe in a sample comprising measuring a Raman or an infrared spectrum of the sample and subjecting the spectrum to data analysis. In some embodiments, the measuring is automated. In some embodiments, the monitoring is continuous and/or non-invasive and/or non-destructive. Also provided is a system for detecting a microbe in a sample comprising a means for measuring a Raman spectrum or an infrared spectrum of the sample and subjecting the spectrum to data analysis. In some embodiments, the measuring is automated. In some embodiments, the monitoring is continuous and/or non-invasive and/or non-destructive. Also provided are methods and systems for assaying a test agent.
G01N 21/3577 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de liquides, p. ex. l'eau polluée
64.
METHODS AND SYSTEMS FOR MICROBIAL DETECTION USING RAMAN AND INFRARED SPECTROSCOPY
Provided is a method for detecting a microbe in a sample comprising measuring a Raman or an infrared spectrum of the sample and subjecting the spectrum to data analysis. In some embodiments, the measuring is automated. In some embodiments, the monitoring is continuous and/or non-invasive and/or non- destructive. Also provided is a system for detecting a microbe in a sample comprising a means for measuring a Raman spectrum or an infrared spectrum of the sample and subjecting the spectrum to data analysis. In some embodiments, the measuring is automated. In some embodiments, the monitoring is continuous and/or non-invasive and/or non-destructive. Also provided are methods and systems for assaying a test agent.
G01N 21/3577 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de liquides, p. ex. l'eau polluée
Methods for treating a B-cell malignancy in a human subject are described. The methods involve determining the presence or absence of a B-cell activating mutation in a gene(s) obtained from the subject. Methods include treatment with the compound of formula (I).
A cell manufacturing management platform facilitates management of a cell manufacturing process. The cell manufacturing management platform tracks events associated with a cell manufacturing process and coordinates between disparate entities involved in the process. The cell manufacturing management platform utilizes machine learning techniques to generate inferences associated with event scheduling in a manner that optimizes an efficiency metric and reduces likelihood of exceptions occurring. Machine learning models may furthermore be used to generate various alerts or other actions associated with the process. A user interface enables different participating entities to track progress of the process and upcoming events.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
67.
FORMULATIONS, CRYSTALLINE FORMS AND DOSAGE REGIMENS OF A MALT1 INHIBITOR
The present invention relates to the amorphous solid dispersions and crystalline forms of a MALT1 inhibitor. The present invention also relates to dosage regimens of the MALT1 inhibitor for the treatment of diseases, syndromes, conditions, and disorders affected by the inhibition of MALT1.
There is described a contact lens package containing a bowl for holding a contact lens and a flange around the bowl which may be made from a different polymer material than the bowl. The packages comprise at least one interface tab with at least one slot so that the second polymer material forming the flange can encapsulate the tab providing a mechanical interlock displaying good flexural strength.
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproiiferative neoplasms (MPN); and diabetes.
A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
70.
Bone Plating Assembly Having a Screw Guide, And Related Systems And Methods
A screw guide for connecting to a bone plate includes a body having proximal and distal ends spaced from each other along a direction. The distal end has a coupling mechanism for coupling to the bone plate at an orientation. The body defines at least one channel that extends along a central axis and is configured to receive a bone fastener therein in a pre-loaded position. The coupling mechanism is configured such that the central axis substantially aligns with a central axis of a fastener hole of the bone plate when coupled to the bone plate at the orientation. The body has a retention mechanism at least partially located within the at least one channel and configured to apply a retention force to the bone fastener for retaining the bone fastener within the channel in the pre-loaded position.
An example apparatus is provided for bone fixation. The apparatus may include a nail, a suture lock, a tightening device, and a suture. The nail may include a proximal end and a distal end, with the suture lock being disposed at the proximal end of the nail. The suture may extend at least between the suture lock and the tightening device. Actuating the tightening device may transition the suture lock from an unlocked position to a locked position.
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour la suture des plaiesSupports ou emballages pour aiguilles ou matériaux de suture
A surgical system includes a detector that includes an array of pixels configured to detect light reflected by a surgical device and generate a first signal. The first signal includes a first dataset representative of a visible image of the surgical device. The surgical system also includes a processor configured to receive the first signal and a second signal representative of one or more operating parameters of the surgical device. The processor is also configured to generate a modified image of the surgical device that includes information related to one or more operating parameters.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 34/35 - Robots chirurgicaux pour la téléchirurgie
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
A61B 90/50 - Supports pour instruments chirurgicaux, p. ex. bras articulés
G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
G06T 19/00 - Transformation de modèles ou d'images tridimensionnels [3D] pour infographie
G06V 10/26 - Segmentation de formes dans le champ d’imageDécoupage ou fusion d’éléments d’image visant à établir la région de motif, p. ex. techniques de regroupementDétection d’occlusion
G06V 20/20 - ScènesÉléments spécifiques à la scène dans les scènes de réalité augmentée
H04N 13/239 - Générateurs de signaux d’images utilisant des caméras à images stéréoscopiques utilisant deux capteurs d’images 2D dont la position relative est égale ou en correspondance à l’intervalle oculaire
H04N 13/337 - Affichage pour le visionnement à l’aide de lunettes spéciales ou de visiocasques utilisant le multiplexage par polarisation
H04N 13/344 - Affichage pour le visionnement à l’aide de lunettes spéciales ou de visiocasques avec des visiocasques portant des affichages gauche et droit
73.
SURGICAL STAPLER WITH FIRING LOCKOUT FEATURE COUPLED TO END EFFECTOR KNIFE
An apparatus (1000) includes an end effector (1200, 2200, 2300, 3200, 4200, 5200), a first flexible coil (508, 1508), a second flexible coil (510, 1510), and a pivoting lock (1270, 2270, 2370, 3270, 4270, 5270). The end effector includes a first jaw (1202, 2202, 2302, 3202, 4202, 5202), a second jaw (1202), and a knife (1206, 2206, 2306, 3206, 4206, 5206). The first and second flexible coils are operatively attached to an upper portion (1238, 2238, 2338, 3238, 4238, 5238) and a lower portion (1246, 2246, 2346, 3246, 4246, 5246) of the knife, respectively. The pivoting lock is pivotable from an unlocked configuration to a locked-out configuration about a pivot axis located vertically between the first and second flexible coils to inhibit distal actuation of the knife. The knife can move the pivoting lock relative to the first and second jaws along the firing stroke.
An apparatus includes a body (700), a shaft (600A), an end effector (200), and a lockout assembly (1100). The end effector includes a cartridge jaw (202), an anvil jaw (204), a knife (206) and a distal retainer (1110). The lockout assembly includes a sensor (1120) and a lockout (1140). The lockout is vertically constrained. The sensor is associated with a first pivot (1124) and a second pivot. The first pivot is grounded with respect to a channel (1114). The second pivot is a moving pivot. The lockout assembly includes an unlocked and locked position. The second pivot is positioned above the first pivot when the lockout assembly is in the unlocked position with the lockout providing no interference with respect to actuation of the knife. The first pivot and the second pivot are positioned at substantially the same height when the lockout assembly is in the locked position.
An end effector of a surgical instrument may be equipped with a firing redirect assembly including: a firing carrier; a reaction pulley disposed distally from the firing carrier; a firing cable coupled to a distal end of the firing carrier and wrapping around the reaction pulley and extending proximally past the firing carrier; and a reaction cable coupled to and extending between a distal end of the reaction pulley and a proximal end of an end effector of the surgical tool, the end effector including a cartridge jaw and an anvil jaw pivotably connected to the cartridge jaw at a pivot, where a firing load on the firing cable in a proximal direction causes the firing carrier to translate distally and causes the reaction pulley and the reaction cable to translate proximally, thereby assisting with closing the anvil jaw or assisting with stabilizing an articulation joint of the end effector.
An apparatus includes a staple, a body, a staple driver, and an alignment feature. The alignment feature is coupled to or formed with at least one of the staple driver or an inner surface of the staple aperture of the body. The alignment feature is configured to minimize rotation of the staple driver. The alignment feature includes at least one of a first contact feature, an alignment member, an alignment member, or an inwardly tapering portion. The first contact feature projects beyond a first lateral side of the staple driver. The alignment member extends through at least a portion of the staple driver. The first connecting portion rigidly connects the inner surface of the staple aperture with the staple driver in a connected state. The inwardly tapering portion of the inner surface or the staple driver is configured to guide the staple driver.
The present invention provides a surgical stapler, wherein the surgical stapler includes an anvil portion, a part of a tissue contacting surface of the anvil portion on one side of a staple-forming recess has a first width, a part of the tissue contacting surface on the other side of the staple-forming recess has a second width, and the first width is greater than the second width. This configuration allows as much as possible for a certain error when firing a retaining pin. For example, even if the retaining pin is not accurately received by a retaining pin recess, an end portion of the retaining pin will abut against the increased tissue contacting surface of the anvil portion without missing the anvil portion and entering tissue. The retaining pin abuts against the enlarged tissue contacting surface, thereby resisting actuation of the anvil portion and a staple cartridge toward a closed configuration, which can enable an operator to perceive abnormal actuation of a guide pin. In addition, the retaining pin abutting against the tissue contacting surface of the anvil portion may be returned to the retaining pin recess with subsequent slight shaking or a similar operation, to allow for subsequent surgical procedures.
A61B 17/072 - Agrafeuses chirurgicales pour appliquer une rangée d'agrafes en une seule opération, p. ex. agrafes appliquées simultanément
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
78.
KLK2XCD3 ANTIBODY AND AN ANTI-CANCER AGENT FOR TREATING PROSTATE CANCER
The application describes the first-in-human study on using a anti-KLK2xCD3 bispecific antibody and another anti-cancer drug, in particular, in particular a taxane chemotherapy or Androgen Receptor Pathway Inhibitor (ARPI), to provide enhanced antitumor efficacy with a deeper and more durable clinical response.
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/40 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre des enzymes
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
Electrophysiology system for use in diagnostic procedures in the field of cardiology and for use in cardiac ablation procedures, consisting of an interface unit, location pad for placement under the patient for use in tracking the location of a catheter during diagnostic and cardiac ablation procedures, adapters for connecting catheters to the interface unit, computer hardware, display monitor, computer software, adaptor cables for catheters, and connector cables, all sold as a unit
80.
KNIFE DESIGNS FOR END EFFECTORS USED IN SURGICAL TOOLS
An end effector of a surgical tool includes opposing first and second jaws, a knife slot defined in one or both of the first and second jaws, and a monolithic knife assembly comprising a drive rod and a blade distally extending from the drive rod and extendable through the knife slot, the drive rod and the blade made from a same material.
A catheter that includes an inner lumen liner comprising a first polymer material, a braided metal wire jacket comprising a plurality of metal wires coated in the first polymer material, and an outer liner comprising a second polymer material different from the first polymer material. A portion of the plurality of metal wires are partially exposed on an outer surface of the outer liner and the coating on the exposed portion of the plurality of metal wires forms a contact surface.
An intravascular device that includes a delivery sheath, a shaped braid comprising a distal braid layer and a proximal braid layer, and an inner member comprising a proximal end and a distal end, the inner member disposed between the proximal braid layer and the distal braid layer of the shaped braid. The intravascular device further includes a first configuration, the shaped braid and the inner member having a first length, and a second configuration, the shaped braid and the inner member having a second length wherein the first length is greater than the second length.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
83.
POWERED SURGICAL TOOL WITH AN OSCILLATING SAW BLADE
In general, devices, systems, and methods for assembly and operation of a handheld oscillating surgical saw are provided. In exemplary embodiments, a surgical tool includes a handpiece comprising a coupling head that includes a slot and a magnet, the slot being configured to releasably receive a surgical saw blade configured to cut bone, and the magnet being configured to magnetically attract the saw blade, wherein the coupling head is configured to move between a first position, in which the slot has a first height and the coupling head is configured to selectively receive the surgical saw blade therein and release the surgical saw blade therefrom, and a second position, in which the slot has a second height that is less than the first height and the coupling head is configured to fixedly seat the saw blade therein.
A molecule comprising a first means of binding to a first antigen expressed on a regulatory T (Treg) cell, and a second means capable of binding to a second antigen expressed on the Treg cell, wherein the molecule is capable of inhibiting growth or proliferation of or depleting a Treg cell.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
85.
Compositions of Phosphorylated Tau Peptides and Uses Thereof
Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described. Pharmaceutical compositions and uses of the liposomes and/or conjugates for treating or preventing a neurodegenerative disease or disorder, such as Alzheimer's Disease, are also described.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 9/1271 - Liposomes non conventionnels, p. ex. liposomes modifiés par un PEG ou liposomes enduits de ou greffés avec des polymères
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Provided herein are anti-LTßR multispecific binding molecules, nucleic acids encoding the anti- LTßR multispecific binding molecules, vectors comprising the nucleic acids, host cells comprising the vectors, and pharmaceutical compositions comprising the anti-LTßR multispecific binding molecules. Also provided are methods of treating cancer in a subject in need thereof, the methods comprising administering the pharmaceutical compositions disclosed herein.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
Provided herein are anti-LTβR multispecific binding molecules, nucleic acids encoding the anti-LTβR multispecific binding molecules, vectors comprising the nucleic acids, host cells comprising the vectors, and pharmaceutical compositions comprising the anti-LTβR multispecific binding molecules. Also provided are methods of treating cancer in a subject in need thereof, the methods comprising administering the pharmaceutical compositions disclosed herein.
C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
88.
IMMUNOCONJUGATES COMPRISING KALLIKREIN RELATED PEPTIDASE 2 ANTIGEN BINDING DOMAINS AND THEIR USES
Provided herein are immunoconjugates, such as radioimmunoconjugates, comprising a therapeutic moiety conjugated to an antibody or antigen binding domain with binding specificity for hK2. In certain embodiments, the hK2-specific immunoconjugate demonstrates a short half-life. Also provided herein are methods of using the immunoconjugates for selectively targeting cancer cells and for treating diseases such as prostate cancer.
A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
C07K 16/40 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre des enzymes
The disclosure provides crystalline and amorphous forms of aticaprant. Also provided by the disclosure are pharmaceutical compositions comprising the amorphous or crystalline forms, methods of treating major depressive disorder using the amorphous or crystalline forms of aticaprant, amorphous or crystalline forms of aticaprant for use in the treatment of major depressive disorder in a human patient having anhedonia, uses of the amorphous or crystalline forms of aticaprant in the manufacture of a medicament for the treatment of major depressive disorder, and packages or pharmaceutical products comprising (i) amorphous or crystalline forms of aticaprant and (ii) instructions for treating major depressive disorder. In some aspects, the human patient treated as described herein has anhedonia.
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
The disclosure provides compositions containing pure aticaprant, solvates of aticaprant, and methods of treating major depressive disorder using aticaprant.
C07D 207/06 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux contenant uniquement des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
An orthopaedic surgical instrument includes an assembly collar having a cavity extending between a superior opening and an inferior opening. The cavity is sized to receive a tapered trunnion of an implanted femoral stem. A bore extends between an inferior end and a superior end of the assembly collar and is configured to align with an implant bore formed in the implanted femoral stem. The bore and the implant bore are configured to receive a fastener to secure the assembly collar to the implanted femoral stem. A method of utilizing the orthopaedic surgical instrument is also contemplated.
An assembly includes an applicator, which includes a housing defining a gap configured to receive an end effector jaw of a surgical stapler. The applicator also includes a platform positioned within the gap. The assembly also includes a buttress assembly having a first length and positioned on the platform. The assembly further includes a trimming feature presented by the applicator or the buttress assembly, and configured to facilitate trimming of the buttress assembly from the first length to a predetermined second length.
A surgical tool that includes a drive housing, an elongate shaft that extends from the drive housing, and an end effector arranged at a distal end of the elongate shaft and including a jaw secured to a jaw holder, the jaw providing a conductive plate and the jaw holder defining a passage. A wrist couples the end effector to the elongate shaft and includes a distal clevis having an axle that rotatably mounts the jaw holder to the distal clevis. An electrical conductor extends from the drive housing, through the wrist and the passage, and terminates at the conductive plate to supply electrical energy to the jaw.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
A61K 31/4166 - 1,3-Diazoles ayant des groupes oxo liés directement à l'hétérocycle, p. ex. phénytoïne
Surgical implants made of artificial materials; medical devices, namely, breast implants made of artificial materials and artificial breast implants in the nature of breast tissue expanders
98.
SYSTEM, METHOD, AND APPARATUS FOR MEDICAL SYSTEM GOVERNANCE
A medical system governance platform is configured to determine an occurrence of a trigger event, wherein the trigger event initiates a governance check to be performed on data associated with the trigger event, obtain, as part of the governance check, governance metadata corresponding to the data associated with the trigger event, wherein the governance metadata is associated with at least one rule base for the data associated with the trigger event, obtain, as part of the governance check, a governance parameter based on at least one of the governance metadata, a parameter associated with the trigger event, and the at least one rule base, wherein the governance parameter is indicative of a governance action related to the data associated with the trigger event, and initiate performance of a governance action based on an evaluation of the governance parameter.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
100.
SYSTEM, METHOD, AND APPARATUS FOR MEDICAL SYSTEM GOVERNANCE
A medical system governance platform is configured to determine an occurrence of a trigger event, wherein the trigger event initiates a governance check to be performed on data associated with the trigger event, obtain, as part of the governance check, governance metadata corresponding to the data associated with the trigger event, wherein the governance metadata is associated with at least one rule base for the data associated with the trigger event, obtain, as part of the governance check, a governance parameter based on at least one of the governance metadata, a parameter associated with the trigger event, and the at least one rule base, wherein the governance parameter is indicative of a governance action related to the data associated with the trigger event, and initiate performance of a governance action based on an evaluation of the governance parameter.
