09 - Appareils et instruments scientifiques et électriques
Produits et services
Computer software module for use in the field of
electrophysiology for medical imaging of cardiac anatomy
used in conjunction with medical diagnostic mapping systems.
5.
METHOD OF ADMINISTRATION OF AN ANTI-IFN-ALPHA/-OMEGA ANTIBODY
Methods for administration of an anti-IFN-α/-ω antibody by subcutaneous or intravenous administration in a clinically proven safe amount are provided. Also provided are methods for clinically proven safe treatment of IFN-I mediated diseases, such as systemic lupus erythematosus (SLE), by subcutaneous or intravenous administration of an anti-IFN-α/-ω antibody.
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/4706 - 4-Aminoquinoléines8-Aminoquinoléines, p. ex. chloroquine, primaquine
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
The invention provides analytical methods for identifying and quantifying complex glycoconjugate compositions, in particular for the analysis of a glycoconjugate in a sample comprising at least 4 glycoconjugates.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A method includes receiving or generating an anatomical map of wall tissue of at least a portion of a cardiac chamber, the map superimposed with ablation tags at locations of ablated wall tissue. Upon placing an ablation catheter having one or more electrodes in a vicinity of the wall tissue, at least one electrode among the one or more electrodes is identified, that violates a location proximity criterion to one or more of the ablation tags. The identified at least one electrode is graphically encoded. The anatomical map showing the graphically encoded at least one electrode is displayed to a user.
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
8.
ULTRASONIC SURGICAL INSTRUMENT AND METHOD OF LATERALLY ALIGNING BLADE WITH CLAMP ARM
An ultrasonic surgical instrument includes an end effector with an ultrasonic blade, a shaft assembly, and a body assembly. The shaft assembly has an articulation section, an acoustic waveguide with a flexible waveguide portion, an articulation band configured to drive articulation of the articulation section between a straight configuration and an articulated configuration, and a pin distal to the articulation section and configured to constrain a distal waveguide portion to the end effector. The body assembly has a housing, a transducer assembly, and a compensator operatively connected to the articulation band and the acoustic waveguide. The compensator is configured to longitudinally urge the acoustic waveguide to thereby pivot the ultrasonic blade about the pin for alignment relative to another portion of the end effector.
Systems and subsystems for closing an end effector of a stapler are disclosed. More specifically, the present disclosure relates to systems, devices, and subsystems for attachments for robotic surgeries. The surgical instrument is a robotic attachment. The surgical instrument includes a closure subsystem that moves independently of other subsystems that are operable independently of each other.
A surgical clip applier is provided that includes first and second jaws on a distal end of an elongate shaft, a clip advancing assembly extending through the shaft and configured to advance a distal-most clip from a plurality of clips in the shaft into the first and second jaws. The jaws have opposed inward facing surfaces, and each inward facing surface has a clip track defined therein for receiving and guiding legs of a clip into the first and second jaws. The clip track of at least one of the jaws has at least one deflectable clip retention member disposed therein and configured to apply a biasing force to a leg of a clip disposed within the jaws to thereby retain the clip within the jaws and maintain alignment of the clip with respect to the jaws. The clip track of at least one of the jaws may also have at least one recess or protrusion designed to be complementary to and mate with a protrusion or recess in a clip.
A61B 17/10 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour poser ou retirer les clamps pour blessuresChargeurs de clamps pour blessures
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/128 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical pour appliquer ou enlever les clamps ou les pinces
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
11.
METHODS FOR TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS
Methods of inhibiting the growth or proliferation, or treating, myeloproliferative neoplasm using bi-specific molecules that bind to mutant calreticulin and CD3 are described.
C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
12.
COMBINATION OF MOSNODENVIR AND CLOSE ANALOGS WITH NITD-688 FOR USE IN THE TREATMENT AND PREVENTION OF DENGUE DISEASE
The present invention relates to the use of a combination comprising Compound A selected from a compound of formula (I) or (I'): (I) (I') wherein R1, R2, R3, R1', R2', R3',and R4' have the same meaning as that defined in the claims and the description, or a stereo-isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof and Compound B or a stereo- isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof. The present invention also relates to compositions, in particular pharmaceuticals, comprising such combination, and to uses and methods of treatment of such combinations and compositions in the prevention and/or treatment of dengue viral infections.
A61K 31/4045 - Indole-alkylaminesLeurs amides, p. ex. sérotonine, mélatonine
A61K 31/4365 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique ayant le soufre comme hétéro-atome du cycle, p. ex. ticlopidine
A61P 31/14 - Antiviraux pour le traitement des virus ARN
13.
ULTRASONIC SURGICAL INSTRUMENT AND METHOD OF LATERALLY ALIGNING BLADE WITH CLAMP ARM
An ultrasonic surgical instrument includes an end effector with an ultrasonic blade, a shaft assembly, and a body assembly. The shaft assembly has an articulation section, an acoustic waveguide (56) with a flexible waveguide portion, an articulation band (474, 475) configured to drive articulation of the articulation section between a straight configuration and an articulated configuration, and a pin distal to the articulation section and configured to constrain a distal waveguide portion to the end effector. The body assembly has a housing, a transducer assembly (54), and a compensator (400) operatively connected to the articulation band (474, 475) and the acoustic waveguide (56). The compensator is configured to longitudinally urge the acoustic waveguide to thereby pivot the ultrasonic blade about the pin for alignment relative to another portion of the end effector.
An immunogenic composition that includes an adjuvant and a soluble protein. The adjuvant may be a nanoparticle, such as a zinc chitosan nanoparticle. The soluble protein may comprise a tag, such as a His tag. A method for inducing an immune response in a subject in need thereof, breaking an immune tolerance in a subject in need thereof, and/or for active immunization to prevent a disease in a subject by administering the immunogenic composition. A system for inducing an immune response in a subject in need thereof, breaking an immune tolerance in a subject in need thereof, and/or for active immunization to prevent a disease in a subject that includes the immunogenic composition and a delivery system.
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A method of surgical stapling uses a surgical instrument operable to compress, staple, and cut tissue. The instrument includes a body, a shaft, and an end effector with a pair of jaws. A placement tip extends distally from one of the jaws of the end effector. The placement tip is elastically deformable when the placement tip is subject to a clamping force. In some instances the placement tip includes an arcuate bend, while in other instances the placement tip is straight. The placement tip can have a variety of non-rectangular lateral cross-sectional shapes. In some instances, the placement tip is made of a material of a specified durometer range and having a high color contrast. A distal end of the placement tip may change position based on the state of deflection of the placement tip in response to the clamping force.
A61B 17/29 - Pinces pour la chirurgie faiblement invasive
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
20.
ULTRASONIC SURGICAL INSTRUMENT WITH A SHAFT ASSEMBLY AND ELONGATED WAVEGUIDE SUPPORT ARRANGEMENT
An ultrasonic surgical instrument includes an end effector having an ultrasonic blade, an ultrasonic transducer assembly, and a shaft assembly. The shaft assembly includes a tube, and an waveguide. The waveguide is received within the tube and is acoustically connected between the ultrasonic blade and ultrasonic transducer assembly to communicate ultrasonic vibrations from the ultrasonic transducer assembly to the ultrasonic blade. The waveguide includes an acoustic body, a first isolation structure, a second isolation structure and a sheath. The acoustic body extends along a longitudinal axis. The first isolation structure radially extends about the acoustic body. The second isolation structure radially extends about the acoustic body and is longitudinally spaced from the first isolation structure. The sheath is radially positioned between the first isolation structure and the tube and is further radially positioned between the second isolation structure.
Behavioral data regarding a user's use of the device or interaction with the user's environment can be assessed by one or more machine learning models having been trained to segment a plurality of users into patient subgroups differentiated with regard to one or more eye health conditions. The user may be classified into a patient subgroup, and the user may be presented with a notification and/or educational content related to an associated risk. A communicative connection between the user and a system of an eye health care provider can be established, and the user can be provided with an interface for scheduling an in-person appointment with the eye health care provider.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G06V 40/20 - Mouvements ou comportement, p. ex. reconnaissance des gestes
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
22.
LONG LOCKING ATTACHMENT WASHER FOR NAIL-PLATE COMBO CONSTRUCT
According to an embodiment of the present disclosure, a bone fixation system includes an intramedullary nail and a bone plate. The plate body can be subdivided into different regions, including but not limited to a mid-shaft region and a proximal shaft region. The mid-shaft region and the proximal shaft region optionally have different widths and/or thicknesses in order to increase flexibility of the bone plate. The bone plate defines one or more plate fixation holes, which may be bone fixation holes. The plate fixation holes extend from the outer surface to the bone-facing surface, and are configured to receive various fixation members for affixing the bone plate to the IM nail and/or to the bone. One or more of the plate fixation holes are connected to the bone plate via protruding tabs, such that the plate fixation holes are separate from, yet connected to, the bone plate.
A flexible circuit is herein disclosed. The flexible circuit is intended for insertion into an internal body cavity of a patient. The flexible circuit includes a flexible substrate comprising a bio-compatible material and extending along a substrate plane, a plurality of electrodes disposed on the flexible substrate, and a conductive wire routed along the flexible substrate and connected to one or more of the plurality electrodes by a stitch pattern.
A method includes emitting an ultrasound beam, having a predefined field of view (FOV), from an array of ultrasound transducers in a catheter in an organ of a patient. Echo signals are received in the array, in response to the ultrasound beam. A position of a target object is estimated within the FOV. When the estimated position of the target object violates a centering condition, the FOV of the ultrasound beam is automatically modified to re-meet the centering condition.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
G06T 5/20 - Amélioration ou restauration d'image utilisant des opérateurs locaux
G06T 7/32 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur la corrélation
A flexible circuit is herein disclosed. The flexible circuit is intended for insertion into an internal body cavity of a patient. The flexible circuit includes a flexible substrate comprising a bio-compatible material and extending along a substrate plane, a plurality of electrodes disposed on the flexible substrate, and a conductive wire routed along the flexible substrate and connected to one or more of the plurality electrodes by a stitch pattern.
The present invention relates to antibodies that bind to ENPP3 and antibody-drug conjugates comprising an antibody that binds to ENPP3 conjugated to a drug, such as an auristatin. Also provided herein are methods for treating a solid tumor or leukemia comprising administering such ADCs.
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
The presently described invention teaches isolated polypeptides, including diagnostic, prognostic, and therapeutic polypeptides, such as, for example, polypeptides that are capable of binding to themselves or other polypeptides, said isolated polypeptides comprising an exposed carboxy-terminus (“C-terminus”) fused to a cap domain (e.g., a His cap domain, (His)6 (i.e., HHHHHH (SEQ ID NO:26)), SLSLSPGK (SEQ ID NO:36), AS, or TVAPTESS (SEQ ID NO: 37)). The presently described invention further teaches nucleic acids and/or expression vectors encoding the polypeptides; cells containing the polypeptides, nucleic acids, and/or expression vectors; and compositions comprising the polypeptides. Methods of making the polypeptides, and methods of using the polypeptides are also taught.
A surgical stapling assembly comprising a first jaw, a second jaw, and a staple cartridge assembly positioned in the first jaw is disclosed. The staple cartridge assembly comprises a plurality of staples, a plurality of staple drivers, and a cartridge body. The cartridge body comprises a deck surface configured to support patient tissue, a longitudinal slot defined in the cartridge body, a plurality of staple cavities, and a longitudinal wall extending vertically below the deck surface. The longitudinal wall comprises a first zone comprising a first wall height and a second zone comprising a second wall height. The staple cartridge assembly further comprises a sled movable longitudinally through the cartridge body, wherein the sled is sized and configured resist deflection of the cartridge body during the firing stroke within the second zone.
A surgical instrument and method of compressing tissue includes an end effector and a shaft assembly. The end effector has a jaw and a clamp arm movable between open and closed positions. The shafts assembly includes a clamp actuator having a proximal actuator portion, a distal actuator portion, and a force limiter. The force limiter is longitudinally connected between the proximal and distal actuator portions and configured to transfer movement from the proximal actuator portion to the distal actuator portion up to transferring a predetermined force therethrough. At least a portion of the force limiter is configured to deflect upon exceeding the predetermined force such that the proximal actuator portion is configured to longitudinally move relative to the distal actuator portion and thereby limit a clamping force between the jaw and the clamp arm.
An apparatus includes a body, a shaft, an end effector, and a lockout assembly. The end effector includes a cartridge jaw, an anvil jaw, a knife and a distal retainer. The lockout assembly includes a sensor and a lockout. The lockout is vertically constrained. The sensor is associated with a first pivot and a second pivot. The first pivot is grounded with respect to a channel. The second pivot is a moving pivot. The lockout assembly includes an unlocked and locked position. The second pivot is positioned above the first pivot when the lockout assembly is in the unlocked position with the lockout providing no interference with respect to actuation of the knife. The first pivot and the second pivot are positioned at substantially the same height when the lockout assembly is in the locked position.
A61B 17/072 - Agrafeuses chirurgicales pour appliquer une rangée d'agrafes en une seule opération, p. ex. agrafes appliquées simultanément
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
31.
TREATMENT OF LOCALLY ADVANCED OR METASTATIC EGFR-MUTATED NON-SMALL CELL LUNG CANCER
Disclosed herein are methods of improving the safety and efficacy of a therapy comprising a bispecific epidermal growth factor receptor (EGFR)/ hepatocyte growth factor receptor (c-Met) antibody for the treatment of locally advanced or metastatic EGFR-mutated non-small cell lung cancer (NSCLC).
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
32.
CHIMERIC ANTIGEN RECEPTOR WITH SPACER DOMAINS DERIVED FROM HUMAN IGG
The present disclosure is related to chimeric antigen receptors (CARs) comprising Immunoglobulin G (IgG) derived spacers, e.g., a human IgG hinge and a human IgG Fc derived CAR spacer. IgGl derived spacers confer improved properties to the CARs, e.g., increased cytokine release with respect to CARs not comprising IgG derived spacers. Also provided are cells expressing CARs comprising IgG derived spacers regions and methods to use the CARs to treat diseases or disorders, e.g., cancer.
A61K 40/11 - Lymphocytes T, p. ex. lymphocytes infiltrant les tumeurs [TIL] ou lymphocytes T régulateurs [Treg]Cellules tueuses activées par les lymphokines [LAK]
Described herein are IL-18 variants, and fusion proteins comprising IL-18 variants and anti-PD-1 antibodies or a fragment thereof. Also described herein are methods of using fusion proteins to treat cancer and other conditions.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Downloadable mobile applications for monitoring patients in the field of orthopedic surgery; downloadable mobile applications for use by orthopedic surgery patients featuring instructions in the fields of exercise and fitness and information on surgical procedures, patient preparation for surgical procedures and rehabilitation from surgical procedures; a computer hardware and recorded software system for use in orthopedic surgery for documenting patient information or events relating to orthopedic surgery; downloadable computer software for use in orthopedic surgical planning; downloadable computer software for collecting data during orthopedic surgery; downloadable computer software for use during orthopedic surgery for the purpose of cutting human tissue; downloadable computer software for calibrating and executing settings on external fixation devices; downloadable software for use with a medical device having sensors to assess muscle function, nerve function, and detect nerve proximity from an invasive probe and to identify nerve location for the delivery of therapeutic drugs, implants, and/or instrumentation. Software as a service (SAAS) services featuring software for use in the field of healthcare to assist in the positioning of orthopedic components during surgery, and in preoperative planning and intraoperative analysis of orthopedic surgery; software as a service (SAAS) services featuring software to overlay prosthetic templates on radiological images, perform measurements on the images, and position prosthetic templates; providing online non-downloadable software allowing healthcare providers to stratify and monitor orthopedic surgery patients pre-surgery and post-surgery; providing online, non-downloadable computer software for calibrating settings on external fixation devices; providing online non-downloadable software applications for use in surgical planning, designing and reviewing of patient specific surgical models, surgical instruments, and surgical implants; software as a service (SAAS) services featuring software for use in the overlaying of prosthetic templates on radiological images; providing online non-downloadable software for pre-operative planning and for implant and surgical instrument selection, modification, and design.
36.
ROBOTIC SURGICAL SYSTEM WITH VIRTUAL CONTROL PANEL FOR TOOL ACTUATION
A surgical system includes a detector, comprising an array of pixels configured to detect light reflected by a surgical instrument and generate a first signal comprising a first dataset representative of a visible image of the surgical instrument. The surgical system also includes a processor configured to receive the first signal, generate a modified image of the surgical instrument that includes a control panel. The control panel includes one or more control elements representative of one or more operating parameters of the surgical instrument. The processor is further configured to receive an input to the control panel from a user, the input being effective to change one of the operating parameters. The processor is also configured to generate a command signal based on the input to change the one of the operating parameters.
A61B 1/313 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour l'introduction dans des incisions chirurgicales, p. ex. laparoscopes
A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
A61B 17/29 - Pinces pour la chirurgie faiblement invasive
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
G06V 10/147 - Détails de capteurs, p. ex. lentilles de capteurs
37.
INTEGRATED CONNECTOR WITH PRE-ALIGNMENT EXTERNAL SHROUD AND FIBER POST ENGAGEMENT
Integrated connector for coupling an endoscope to an external emitter and controller. A system includes a plug attached to a cable, wherein the plug includes an alignment shroud, a first fiber optic coupler, and a first data connector. The system includes a receptacle configured to receive the plug, wherein the receptacle includes an alignment receptacle configured to receive the alignment shroud, wherein the alignment receptacle is a negative space defined by a receptacle external shroud and a receptacle internal shroud, a second fiber optic coupler configured to interface with the first fiber optic coupler, and a second data connector configured to interface with the first data connector.
Provided herein are multispecific antibodies, including bispecific antibodies that specifically bind to EMR2 and TRBV19 (also known as Vβ17), and monospecific antibodies that specifically bind to EMR2, and multispecific antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided multispecific antibodies or multispecific antigen-binding fragments, cells expressing the provided multispecific antibodies or multispecific antigen-binding fragments, as well as associated vectors and detectably labeled multispecific antibodies or multispecific antigen-binding fragments. In addition, methods of producing and using the provided multispecific antibodies and multispecific antigen-binding fragments are described.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A system for automated surgical instrument tray inspection includes a user device in communication with an inspection device. The user device captures a test image of an instrument tray being inspected and sends the image to the inspection device. The inspection device determines a unique tray identifier of the instrument tray. The inspection device generates object predictions from the test image with a trained object recognition model, post-processes the object predictions with non-max suppression based on a predetermined tray configuration associated with the tray identifier, and determines whether the object predictions match a predetermined tray layout associated with the tray identifier. The user device displays a user interface indicating whether the object predictions match the predetermined tray layout. Other embodiments are described and claimed.
G06V 10/75 - Organisation de procédés de l’appariement, p. ex. comparaisons simultanées ou séquentielles des caractéristiques d’images ou de vidéosApproches-approximative-fine, p. ex. approches multi-échellesAppariement de motifs d’image ou de vidéoMesures de proximité dans les espaces de caractéristiques utilisant l’analyse de contexteSélection des dictionnaires
G06T 7/33 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur les caractéristiques
G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
G06V 10/774 - Génération d'ensembles de motifs de formationTraitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source méthodes de Bootstrap, p. ex. "bagging” ou “boosting”
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
The present invention relates to novel, selective, radiolabeled compound having monoacylglycerol lipase (MGL) affinity which are useful for imaging and quantifying MGL receptor expression, distribution and enzyme occupancy in tissues, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, the use of such compounds and compositions for imaging a tissue, cells or a host, in vitro or in vivo and to precursors of said compounds.
Apparatus for calibrating a catheter, the apparatus including (i) a catheter mounting device configured to fixedly mount a distal end of a shaft of the catheter, (ii) a grasper configured to couple an expandable distal-end assembly of the catheter to a gauge, the gauge configured to measure a force on the grasper by the expandable distal-end assembly in response to translation of the gauge along one or more mutually orthogonal axes, (iii) a mechanical stage configured to translate the gauge along three mutually orthogonal axes, and (iv) a processor, configured to generate calibration data for the catheter, the calibration data associating multiple translations of the mechanical stage with corresponding force measurements measured by the gauge.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/1495 - Étalonnage ou test des sondes in vivo
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
Embodiments of the present invention relate to methods of treating multiple myeloma in a subject in need thereof comprising administering to the subject a BCMAxCD3 bispecific antibody on a novel dosing schedule.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
Methods of monitoring progression of multiple myeloma or plasmacytoma, particularly relapsed or refractory multiple myeloma, are described. Also described are methods of treating or determining response to a treatment for multiple myeloma or plasmacytoma in a subject.
Articulatable surgical instruments that include a firing system configured to selectively move a firing member between a starting position and an ending position. The firing system includes a flexible upper drive member that axially passes through a flexible upper hollow member to provide upper axial drive motions to the firing member. The firing system also includes a flexible lower drive member that axially passes through a lower hollow member to provide lower axial drive motions to the firing member.
Described is an ophthalmic device that contains visible light filters. The ophthalmic device is a free radical reaction product of a reactive mixture comprising: one or more monomers suitable for making the ophthalmic device; a first visible light filtering compound, the first visible light filtering compound having a visible light absorption maximum between 430 and 480 nm and a full width half maximum (FWHM) at the visible light absorption maximum of at least 35 nm and up to 150 nanometers, wherein the compound is photostable, and wherein the compound has a molar extinction coefficient of at least 7740 L·mol−1·cm−1; and a second visible light filtering compound. The devices may provide one or more benefits to wearers, including enhanced macular pigment optical density (MPOD), as well as improved color perception and color enhancement.
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
C08F 283/12 - Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères prévus par la sous-classe sur des polysiloxanes
G02C 7/10 - Filtres, p. ex. pour faciliter l'adaptation des yeux à l'obscuritéLunettes de soleil
48.
BLOOD-BASED SCREENING OF SUBJECTS FOR A CLINICAL TRIAL FOR TREATMENT OF TAUOPATHY OR AMYLOIDOGENIC DISEASE
A method of pre-screening a human subject for a clinical trial for treatment of tauopathy or an amyloidogenic disease. The method comprises obtaining a plasma sample from the subject and determining a concentration of p217+tau present in the plasma sample. The method further comprises indicating the subject for further screening for the clinical trial when the concentration of p217+tau present in the plasma sample is greater than or equal to a minimum threshold and less than or equal to a maximum threshold. The minimum threshold corresponds to an amount of p217+tau in plasma over which subjects present with mild cognitive impairment (MCI) and an increased accumulation of tau tangles in the brain as compared to a cognitively normal patient. The maximum threshold corresponds to an amount of p217+tau present in plasma over which subjects present with pathology of widespread accumulation of tau tangles in multiple regions of the brain.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
TPLO plate includes a body and first and second distal holes. The body extends longitudinally from a proximal end to a distal end and defined via a first surface which, in an operative configuration, faces away from a bone and a second surface which, in the operative configuration, faces toward the bone. The body includes a proximal portion configured to be positioned over a cut and repositioned proximal segment of a tibia during a procedure and a distal portion extending along a longitudinal axis and configured to be positioned over a distal segment of the tibia during the procedure. The first hole extends through a proximal end of the distal portion of the body from the first surface to the second surface. The first hole includes an elongated portion and an offset portion open to and in communication with one another. The elongated portion extends along the longitudinal axis and an offset portion extending distally from the elongated portion along an offset axis, which extends at an angle relative to the longitudinal axis. The second hole extends through the distal portion of the body distally of the first hole from the first surface to the second surface. The second hole extends along the longitudinal axis in alignment with the elongated portion of the first hole and including a sloped compression surface along a distal portion thereof. The first hole is configured such that when a first distal compression to the osteotomy cut is applied via insertion of a bone fixation element into a distal portion of the second hole. The element translates along the offset axis from a central axis to a point of intersection to provide a cranial compression to the osteotomy cut.
Described embodiments include a system that includes a current source generator and a processor. The processor is configured to drive the current source generator to supply, for application to tissue of a subject, an electric current having an amplitude that varies in accordance with a predefined function of time, such that the amplitude initially monotonically increases to a maximum value. Other embodiments are also described.
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
51.
SELTOREXANT FOR USE IN TREATING MAJOR DEPRESSIVE DISORDER WITH INSOMNIA SYMPTOMS
The disclosure provides methods for stratifying human patients with MDD in order to identify a human patient with MDD with insomnia symptoms (MDDIS) where such patients can benefit from treatment with an orexin-2 receptor antagonist, such as seltorexant.
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
C07K 14/715 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des cytokinesRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des lymphokinesRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des interférons
53.
BISPECIFIC ANTIBODY TARGETING EMR2 (CD312) AND THE T-CELL RECEPTOR TRBV19
Provided herein are multispecific antibodies, including bispecific antibodies that specifically bind to EMR2 and TRBV19 (also known as Vβ17), and monospecific antibodies that specifically bind to EMR2, and multispecific antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided multispecific antibodies or multispecific antigen-binding fragments, cells expressing the provided multispecific antibodies or multispecific antigen-binding fragments, as well as associated vectors and detectably labeled multispecific antibodies or multispecific antigen-binding fragments. In addition, methods of producing and using the provided multispecific antibodies and multispecific antigen-binding fragments are described.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
54.
COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROSTATE CANCER
Compositions and methods for the treatment of cancer, in particular prostate cancer, are described. According to certain embodiments, a method of treating cancer in a patient comprises administering to the patient a therapeutically effective amount of a radioconjugate, wherein the radioconjugate comprises an antibody or antigen binding domain with binding specificity for hK2.
A delivery device for at least one medical material comprises: an inner tube; an outer sheath sleeved around the inner tube; and a manifold including a main body, wherein the manifold is configured to couple with the inner tube and the outer sheath at a distal side of the main body, and wherein the manifold further includes a crown head connector protruding distally from the main body, wherein a proximal end of the inner tube connects with the crown head connector at a radial inner side of the crown head connector, and a proximal end of the outer sheath detachably couples with the crown head connector at a radial outer side of the crown head connector. A connection system of the delivery device and a method for assembly of the delivery device are provided.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations for human use. Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain
(2) Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body
59.
Deployable arbor sets that break away from staple cartridge
A staple cartridge including a tissue supporting deck and a set of arbor inserts removably coupled to the deck adjacent a staple pocket, the staple pocket being configured to hold a staple. The set of arbor inserts is configured to plastically deform the staple as the staple exits the staple pocket during a firing stroke.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain.
(2) Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain.
(2) Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain.
(2) Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers. Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers. Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Human pharmaceutical preparations for the prevention and treatment of auto-immune diseases, cardiovascular diseases, pulmonary hypertension, pulmonary arterial hypertension, gastro-intestinal diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, cerebrovascular diseases and digital ulcers; human pharmaceutical preparations for the prevention and treatment of metabolic diseases and disorders, namely diabetes, gout, arthritis and anemia; human pharmaceutical preparations for the prevention and treatment of neurological diseases, namely Alzheimer's, Huntington's disease, multiple sclerosis, and cerebral palsy; human pharmaceutical preparations for the prevention and treatment of psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, and schizophrenia; human pharmaceutical preparations for use in dermatology, namely dermatitis, skin pigmentation diseases, psoriasis; Human pharmaceutical preparations for the prevention and treatment of hemolytic disease of the newborn; human pharmaceuticals preparations, namely anxiolytic medications, anti-virals, anti-inflammatories, anti-infectives, anti-allergic medications; human pharmaceutical preparations for the relief of pain.
(2) Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers. Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders, digital ulcers. Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Computer software module for use in the field of electrophysiology for medical imaging of cardiac anatomy used in conjunction with medical diagnostic mapping systems
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body
A method for producing a surgical instrument is disclosed. The method comprises obtaining a handle, wherein the handle comprises a distal end comprising a shaft interface surface and a first set of magnetic elements. The method further comprises obtaining a shaft, wherein the shaft comprises a proximal end comprising a handle interface surface, a second set of magnetic elements, and a third set of magnetic elements. The method further comprises attaching the shaft to the handle, wherein the shaft interface surface is configured to engage the shaft at the handle interface surface, wherein an attractive magnetic force is configured to pull the handle towards the shaft when the first set of magnetic elements interact with the second magnetic elements, and wherein a repulsive magnetic force is configured to repel the handle from the shaft when the first set of magnetic elements interacts with the third set of magnetic elements.
A61B 17/10 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour poser ou retirer les clamps pour blessuresChargeurs de clamps pour blessures
A61B 17/115 - Agrafeuses pour réaliser une anastomose, p. ex. en une seule opération
A61B 17/122 - Clamps ou pinces, p. ex. pour le cordon ombilical
A61B 17/128 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical pour appliquer ou enlever les clamps ou les pinces
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 90/30 - Dispositifs pour éclairer une zone chirurgicale, les dispositifs ayant une corrélation avec d’autres dispositifs chirurgicaux ou avec une intervention chirurgicale
A61B 90/90 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes
A61B 90/96 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes utilisant des symboles, p. ex. du texte utilisant des codes-barres
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes utilisant des moyens électromagnétiques, p. ex. transpondeurs
G16H 40/00 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux
The present invention is directed to a surgical instrument with a robotics system, a memory device and an end effector having an elongate channel, knife position sensor(s) and a firing bar coupled to a knife. In response to drive motions initiated by the robotics system, the firing bar may translate within the elongate channel. As the firing bar translates, the sensor(s) transmit a signal to the memory device. The position of the knife may be determined from the output signals and may be communicated to the robotics system or instrument user. The sensors may be Hall Effect sensors.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/072 - Agrafeuses chirurgicales pour appliquer une rangée d'agrafes en une seule opération, p. ex. agrafes appliquées simultanément
A61B 17/10 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour poser ou retirer les clamps pour blessuresChargeurs de clamps pour blessures
A61B 17/29 - Pinces pour la chirurgie faiblement invasive
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
Various embodiments of surgical robot control systems are disclosed. In one example embodiment, the surgical robot control system comprises a housing. A controller is located within the housing and is coupled to a socket. The socket receives a handheld surgical user interface therein to control a surgical instrument. The surgical instrument is connected to the surgical robot and comprises an end effector and a mechanical interface to manipulate the end effector. The mechanical interface is coupled to the controller. At least one sensor is coupled to the controller and the socket to convert movement of the handheld surgical user interface into electrical signals corresponding to the movement of the surgical instrument. At least one feedback device is coupled to the controller to provide feedback to a user. The feedback is associated with a predetermined function of the surgical instrument.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
Systems, devices, and methods for controlling cooperative surgical instruments are provided. Various aspects of the present disclosure provide for coordinated operation of surgical instruments accessing a common body cavity of a patient from different approaches to achieve a common surgical purpose. For example, various methods, devices, and systems disclosed herein can enable the coordinated treatment of surgical tissue by disparate minimally invasive surgical systems that approach the tissue from varying anatomical spaces and operate in concert with one another to effect a desired surgical treatment.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61B 1/04 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision
A61B 1/313 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour l'introduction dans des incisions chirurgicales, p. ex. laparoscopes
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/11 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour réaliser l'anastomoseBoutons pour anastomose
A61B 17/115 - Agrafeuses pour réaliser une anastomose, p. ex. en une seule opération
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
A luer fitting that included a body having a proximal region, a distal region, and a length therebetween. The body includes: a recessed region within a portion of the length of the body at the proximal region, the recessed region having a proximal end opening, an inner back wall and an inner circumferential sidewall; a barb extending proximally from the inner back wall; and a passage between a first opening at the distal region of the body to a second opening at a proximal end of the barb, the passage forming an inner surface and having a first inner diameter at or near the first opening at the distal region opening that is greater than a second inner diameter at or near the inner back wall of the recessed region, wherein the transition between the first inner diameter and the second inner diameter is curvilinear.
The present invention relates to novel antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of detecting VISTA.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A catheter apparatus, including an elongated deflectable element, a distal assembly, a force sensor disposed between the elongated deflectable element and the distal assembly, and comprising a spring including a tube with at least one helical cut extending around a circumference of the tube, the at least one helical cut including deviations extending in a longitudinal direction of the tube, the deviations being configured to prevent overstretching and overbending of the spring.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A method includes receiving an anatomical map of wall tissue of at least a portion of a cardiac chamber, the map superimposed with a grid of ablation tags that are graphically encoded according to respective levels of ablation of the wall tissue. Upon placing a multi-electrode ablation catheter in a vicinity of the wall tissue, one or more of the ablation tags are graphically re-encoded according to (i) existing levels of ablation associated with the tags and (ii) electrode proximity to wall tissue locations associated with the tags. The anatomical map, having the re-encoded ablation tags, is displated to a user.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
82.
METHOD AND SYSTEM FOR ASSISTING A USER IN GUIDING A CATHETER DURING A CARDIAL OPERATION
A method, apparatus and computer program product, the method comprising: obtaining electrical information from a plurality of electrodes disposed on a distal end assembly of a catheter within a heart of a patient as the catheter is being maneuvered within the heart; dynamically identifying a portion of the distal end assembly that is displaced from tissue wall of the heart, based upon the electrical information received from the plurality of electrodes; generating a visual representation of the distal end assembly; dynamically distorting the visual representation by warping (the identified portion of the distal end assembly; and rendering the visual representation as dynamically distorted to the display device.
A61B 5/343 - Indication de la répartition des potentiels électriques
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/0538 - Mesure de l'impédance ou de la conductivité électrique d'une partie du corps invasive, p. ex. en utilisant un cathéter
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
A61B 5/287 - Supports pour électrodes multiples, p. ex. cathéters à électrode pour des études électrophysiologiques [EEP]
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
83.
SURGICAL INSTRUMENT WITH DUAL GRIP END EFFECTOR AND RELATED METHODS
An apparatus includes a first jaw member including a first needle clamp pad and a first suture clamp pad. The apparatus also includes a second jaw member including a second needle clamp pad and a second suture clamp pad. The first and second jaw members are pivotable relative to each other between an open state, a first closed state in which the first and second suture clamp pads are configured to cooperate with each other to securely grip a suture, and a second closed state in which the first and second needle clamp pads are configured to cooperate with each other to securely grip a needle.
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour la suture des plaiesSupports ou emballages pour aiguilles ou matériaux de suture
A61B 17/062 - Dispositifs pour manipuler les aiguilles
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Human pharmaceutical preparations for the prevention and treatment of viral diseases, auto-immune and inflammatory diseases, alloimmune diseases, cardiovascular and pulmonary diseases, central nervous system diseases, peripheral neurological system diseases, pain, dermatologic diseases, gastro-intestinal diseases, infectious-related diseases, metabolic diseases, oncologic diseases, ophthalmic diseases, respiratory diseases, hematological diseases, urological diseases, maternal fetal disorders Medical apparatus for introducing pharmaceutical preparations into the human body; implantable medical device for introducing pharmaceutical preparations into the human body
An apparatus includes a first jaw member including a first needle clamp pad and a first suture clamp pad. The apparatus also includes a second jaw member including a second needle clamp pad and a second suture clamp pad. The first and second jaw members are pivotable relative to each other between an open state, a first closed state in which the first and second suture clamp pads are configured to cooperate with each other to securely grip a suture, and a second closed state in which the first and second needle clamp pads are configured to cooperate with each other to securely grip a needle.
A surgical stapler includes a first elongate member having a distal portion that supports an anvil surface, and a second elongate member having a distal portion configured to receive a staple cartridge. The stapler further includes a pin rotatably coupled with the first elongate member, and a clamp member movably coupled with the second elongate member. The clamp member is operable to releasably capture the pin to thereby clamp the first elongate member against the second elongate member. The pin is configured to rotate relative to the first elongate member in response to being captured by the clamp member.
A method includes, receiving: (i) a selected three-dimensional (3D) section that has been ablated in a patient organ in accordance with a specified contour, and (ii) a dataset, which is indicative of a set of lesions formed during ablation of the selected 3D section. The selected 3D section is transformed into a two-dimensional (2D) map, and checking, on the 2D map, whether the set of lesions covers the specified contour.
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
A luer fitting that included a body having a proximal region, a distal region, and a length therebetween. The body includes: a recessed region within a portion of the length of the body at the proximal region, the recessed region having a proximal end opening, an inner back wall and an inner circumferential sidewall; a barb extending proximally from the inner back wall; and a passage between a first opening at the distal region of the body to a second opening at a proximal end of the barb, the passage forming an inner surface and having a first inner diameter at or near the first opening at the distal region opening that is greater than a second inner diameter at or near the inner back wall of the recessed region, wherein the transition between the first inner diameter and the second inner diameter is curvilinear.
A staple cartridge including: a cartridge body; a staple pocket in the cartridge body, the staple pocket having an opening and containing an unformed staple including a first leg and a second leg, the staple pocket containing the first leg and the second leg of the unformed staple in an unfired position; and two or more guide surfaces in the staple pocket disposed adjacent the opening, wherein the guide surfaces are configured to deform the first leg of the unformed staple as the first leg exits the staple pocket at the opening during a firing of the unformed staple.
A surgical instrument includes an end effector, a shaft assembly, and an axial location feature. The end effector includes an ultrasonic blade and a clamp arm that can move between an open and closed position. The shaft assembly includes a proximal shaft portion, an acoustic waveguide extending proximally from the ultrasonic blade, a distal shaft portion extending along a distal axis, and an articulation section interposed between the proximal shaft portion and the distal shaft portion. The articulation section can deflect the distal shaft portion and the end effector relative to the longitudinal axis between a non-deflected position and a deflected position. The axial location feature can inhibit the ultrasonic blade from shifting relative to the clamp arm along the distal axis as the end effector is driven between the non-deflected position and the deflected position.
A depth limiter that is configured to couple with first and second trocar cannulas having different diameters. The depth limiter includes first and second body portions. First and second body portions each include first and second gripping surfaces. The first and second body portions are pivotably coupled together and are movable between an open configuration and a closed configuration. In the open configuration, the first and second body portions are configured to allow for axial movement of the depth limiter relative to the first and second trocar cannulas. The first gripping surfaces of the first and second body portions are configured to restrict axial movement of the depth limiter relative to the first trocar cannula in the closed configuration. The second gripping surfaces of the first and second body portions are configured to restrict axial movement of the depth limiter relative to the second trocar cannula in the closed configuration.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
96.
ELECTRONIC POWER SYSTEM WITH MODULAR SEALED ENCLOSURE
The disclosed technology includes a sterilizable powered electronics system for a surgical instrument that includes a boost regulator circuit, an ultracapacitor, and a sealed enclosure. The boost regulator circuit is configured to electrically connect to one or more batteries and output at least one of a predetermined voltage or a predetermined current. The ultracapacitor is electrically connected to the boost regulator circuit. The sealed enclosure encloses the boost regulator circuit and is configured to withstand temperatures greater than 50° C. and pressures greater than 15 psi. At least one of the boost regulator circuit or the ultracapacitor can be configured to be electrically connected to an instrument motor.
H02P 23/00 - Dispositions ou procédés pour la commande de moteurs à courant alternatif caractérisés par un procédé de commande autre que la commande par vecteur
The present invention concerns pharmaceutical formulations of apalutamide, which can be administered to a mammal, in particular a human, suffering from an androgen receptor (AR)-related disease or condition, in particular cancer, more in particular prostate cancer.
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate or enhance or mimic VISTA's suppressive effects on T cell immunity and thereby suppress T cell immunity. These agonist antibodies and antibody fragments are especially useful in the treatment of autoimmunity, allergy, inflammatory conditions, GVHD, sepsis and transplant recipients. Screening assays for identifying these agonists are also provided.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
An orthopaedic surgical instrument may include an elongated body with a broach end and an impactor end. The body may be straight or curved. A latch lever may be pivotally coupled to the elongated body. The latch lever may be moveable between an open position and a latched position in which the latch lever is retained within the body. A surgical broach may be rigidly attached to the broach end of the elongated body. An automated surgical impactor may be attached to the impactor end.
A system includes an input device and a processor. The processor is configured to (i) one of receive and generate an electrophysiological (EP) map that visualizes a first EP parameter on the EP map with a graphical representation that varies in size according to a value of the first EP parameter, (ii) receive, using the input device, a second EP parameter, (iii) apply a visual indication of the second EP parameter on the graphical representation of the first EP parameter, wherein the visual indication varies according to a value of the second EP parameter, and (iv) display the EP map to the user on a display device.
