An instrument includes a body assembly, a shaft assembly, and an end effector. The end effector includes a first jaw and a second jaw. The end effector is configured to grasp tissue between the first jaw and the second jaw. The shaft is positioned between the body assembly and the end effector. The second jaw includes a second jaw body, which includes at least one recess. The second jaw further includes an electrode assembly. The electrode assembly includes at least one protrusion extending toward the second jaw body. The at least one protrusion is sized to fit inside a respective recess of the at least one recess and is configured to align the electrode assembly to the second jaw body.
A61B 18/08 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
A bone correction system is configured to attach to the medial cuneiform and the first metatarsal of a patient's foot in a deformed configuration. An articulation joint is configured to rotate and angulate the first metatarsal with respect to the medial cuneiform. A translation assembly is configured to cause the first metatarsal to travel toward and/or against the medial cuneiform. Thus, the bone correction system is configured to iterate the patient's foot from the deformed configuration to a corrected configuration. A bone plate can permanently fix the medial cuneiform and the first metatarsal in the corrected configuration.
Formulations for highly purified viral particles (e.g., adeno-associated virus (AAV) particles) are provided herein. The formulations include purified AAV particles that are substantially free of impurities (e.g., product-related impurities and process-related impurities), and one or more of a buffering agent, a cryoprotectant, a non-ionic surfactant, and optionally a pharmaceutically acceptable salt. In certain aspects, the formulation maintains or enhances stability and/or reduces or prevents aggregation of the purified AAV particles.
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
4.
STRENGTHENED EXPANDABLE BASKETS FOR MEDICAL PROBES AND MEDICAL PROBES CONTAINING STRENGTHEN EXPANDABLE BASKETS
An example expandable basket assembly for a medical probe may include a plurality of spines extending along a longitudinal axis from a proximal central proximal spine portion to a distal spine portion. The distal spine portion may define a cloverleaf structure disposed radially around the longitudinal axis. The cloverleaf structure may define a central cutout with a central area disposed about the longitudinal axis. The cloverleaf structure may include a sinusoidal-like member extending from one spine to an adjacent spine in a direction around the longitudinal axis. The sinusoidal-like member may include a plurality of distal facing portions, a plurality of proximal facing portions, and at least one side connector connecting two adjacent distal facing portions to one another. The at least one side connector may strengthen a distal end of the expandable basket.
A method includes dividing a three-dimensional (3D) rendering of at least a portion of a heart into voxels having coordinates in a coordinate system of a position mapping system. Using a position tracking system, positions of one or more electrodes of a catheter are measured inside the heart during an ablation session that comprises multiple ablation instances. Each measured position is assigned a predefined number of voxels nearest to the position. A respective ablation score is calculated for each voxel, the ablation score representing at least a number of the ablation instances affecting the voxel. A respective ablation tag is assigned to each voxel and the ablation tag is graphically encoded according to the ablation score of the voxel. The graphically encoded ablation tags are overlaid on the 3D rendering to generate an ablation map. The ablation map is presented to a user.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G06T 19/20 - Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A guiding sheath has a hemostatic valve and a central lumen into which a diagnostic or treatment catheter can be introduced and guided into a patient. The hemostatic valve also includes an electrically conducting element or proximity sensing element on its proximal end that interacts with a second electrically conducting element or proximity sensing element on a proximal end of the diagnostic or treatment catheter that can be passed through the central lumen of the guiding sheath and into the patient's heart. The interaction between the two electrically conducting elements or proximity sensing elements enables the location of the distal end of the diagnostic or treatment catheter in the patient's heart without the need for irradiating the patient.
Described are polymerizable fused tricyclic compounds of formula I:
Described are polymerizable fused tricyclic compounds of formula I:
Described are polymerizable fused tricyclic compounds of formula I:
wherein R1, R2, R3, m, n, t, and rings B, C, and D are as defined herein. The compounds absorb various wavelengths of ultraviolet and/or visible light (such as high energy visible light) and are suitable for incorporation in a variety of products, such as biomedical devices and ophthalmic devices.
C07D 219/02 - Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
C07D 335/20 - Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
8.
CATHETER HAVING A DISTAL END WITH A MULTIPLE LAYER REINFORCEMENT
A catheter for navigating within the vasculature of a body includes a liner, a braid disposed about the liner, and a jacket disposed about the braid. The liner has a proximal end, a distal end, an outer surface, an internal lumen extending from the proximal end to the distal end, and a longitudinal axis. The braid is disposed on the outer surface of the liner. The braid has a proximal end, and a distal end. The braid extends from the proximal end of the liner to the distal end of the liner. The distal end of the braid is folded over upon itself by a predetermined distance to form a first fold line and a double braid comprising of a radially inner braid layer and a radially outer layer at a distal segment of the braid.
A surgical tool includes a drive housing, a capstan assembly rotatably mounted within the drive housing and including a drive gear rotatable about a rotational axis, a longitudinally driven gear arranged within the drive housing and engageable with the drive gear such that the longitudinally driven gear translates longitudinally in response to rotation of the drive gear, a drive rod operatively coupled to and extending from the longitudinally driven gear, and a coupling that rotatably couples the drive rod to the longitudinally driven gear such that the drive rod is rotatable about a longitudinal axis of the drive rod and relative to the longitudinally driven gear.
An industrial automation system may separate a foil cover sheet of a contact lens package from its body to enable, for example, sustainable practices such as recycling, repackaging, relabeling, flexible storing, and the like. The system may include a press and a gripper. The press may be configured to displace a portion of the package to generate an edge separation between the package foil cover sheet and body. The gripper may grasp the sheet at the edge separation and detach the sheet from the body.
In an external fixation device, adjustments in length (contracting or extending a strut) are carried out by respective motorized actuators of the struts, which are programmed to operate according to an actuation plan. In some embodiments, a total required change in length is defined for each of the struts, and based on the intended number of treatment days, a daily change in length is defined for the strut. Then, taking into account the number of intended device actuations per day, a change in length for each actuation is defined. Since the total required change in length may differ for different struts of the same device, the changes in length (whether at a single actuation or as a daily, cumulative change in length) can differ between the different struts.
A61B 17/62 - Ring frames, i.e. devices extending around the bones to be positioned
A61B 17/66 - Compression or distraction mechanisms
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
12.
SMART SHOULDER TISSUE SPARING APPROACH TECHNIQUES AND RELATED INSTRUMENTATION
Procedures for performing shoulder arthroplasties are disclosed, such procedures including performing various preparation steps for the humerus and glenoid to receive implants, and proceeding through placement of implants and/or prostheses at the surgical site. The techniques disclosed afford the benefit of being tissue sparing, and thus minimize damage or trauma to tissue at the surgical site, including allowing the subscapularis tendon to remain intact throughout the procedures. Various devices that enable the procedures are disclosed, including but not limited to humeral resection guides, glenoid guides, humeral guides, and handle assemblies, among other tools, components, and the like that can be used with such devices. In at least some embodiments, preparation steps include resecting a humeral head, and reaming and broaching the resulting humeral resection surface to receive an implant, and then a prosthesis, as well as reaming a glenoid so it can also receive an implant.
The present invention relates to methods of treating prostate cancer in a subject in need thereof, comprising administering a therapeutically effective amount of a KLK2xCD3 bispecific antibody or bispecific binding fragment thereof to the subject to treat the prostate cancer.
C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/04 - Antineoplastic agents specific for metastasis
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
14.
PRESENTING QUALITY MEASURES OF TISSUE ABLATION IN A BLOOD VESSEL USING A TWO-DIMENSIONAL MAP
A method includes, receiving multiple signals from multiple respective electrodes arranged along an inner circumference of a blood vessel that has been ablated. Based on the multiple signals, one or more quality measures of the ablated blood vessel are produced. A graphical presentation indicative of the one or more quality measures, is displayed to a user in a two-dimensional (2D) polar coordinate system.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A method may comprise receiving, by a processor from one or more sensors, a three-dimensional (3D) position of each of a plurality of electrodes of a catheter during an ablation session, generating, by the processor, a 3D graphical representation identifying a position of each of the plurality of electrodes with a first indication, and connecting, by the processor, pairs of adjacent first indications with a second indication in the constellation-like 3D graphical representation. The second indications may indicate locations between electrodes where energy was delivered. The method may comprise displaying, by the processor on a display device, the 3D graphical representation comprising the first indications and the second indications. The method may comprise identifying pairs of adjacent first indications, that are not connected by a second indication, with a third indication, which may indicate locations between electrodes where energy was not delivered.
A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
16.
Dosing Regimens Associated With Extended Release Paliperidone Injectable Formulations
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
An instrument includes a body assembly, a shaft assembly, and an end effector. The end effector includes a first jaw and a second jaw. The end effector is configured to grasp tissue between the first jaw and the second jaw. The shaft is positioned between the body assembly and the end effector. The second jaw includes a second jaw body, which includes at least one recess. The second jaw further includes an electrode assembly. The electrode assembly includes at least one protrusion extending toward the second jaw body. The at least one protrusion is sized to fit inside a respective recess of the at least one recess and is configured to align the electrode assembly to the second jaw body.
An automated surgical staple inspection system automatically generates surgical staple inspection data characterizing a set of staples fired into a test skin by stapling device in a staple test. An inspection processing device obtains one or more images of the set of staples and applies an object detection model to infer locations of the staples and respective classes of the staples indicating whether the staples are properly formed or have one or more identified defects. Based on the inferred locations, staples may be mapped to respective positions in an expected staple pattern to generate a staple map. A keypoint detection model furthermore operates to automatically identify a set of keypoints in each staple from which staple height may be determined. The inspection processing device may generate one or more digital reports based on the inspection data, which may be outputted to a user interface of a user device.
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
19.
Display screen with GUI for contact quality indicator of expandable end effectors in computer-aided electrophysiology navigation
Anti-TRDV2 multispecific antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
A system is disclosed including an ablation probe that includes an antenna, a display, and a controller in communication with the ablation probe and the display. The controller comprises a memory and is operable to receive first and second inputs indicative of an amount of time and a power level, respectively, to energize the ablation probe, retrieve, from the memory, a predicted ablation zone corresponding to the first and second inputs, display, on the display, an image representative of the ablation probe, and overlay, on the image, the predicted ablation zone, energize the ablation probe at the power level, and dynamically overlay, on the image, a progressive ablation zone based on the ablation probe being energized, wherein a size of the progressive ablation zone is retrieved from the memory based on the amount of time the ablation probe has been energized at the power level.
A medical probe includes a shaft, a basket assembly, and heat shrink sleeves. The shaft is configured for insertion into an organ of a patient. The basket assembly is mounted at a distal end of the shaft, the basket assembly comprising a plurality of splines. The plurality of electrodes is fitted on the plurality of splines, each electrode defining an outer conductive surface. The heat shrink sleeves are fitted over the electrodes, the sleeves comprising open windows that expose conductive surfaces of the electrodes.
Disclosed are compositions which include reversible complexes of crosslinking pharmaceutical agent and carrageenan. Particularly, the compositions include reversible complexes of crosslinking pharmaceutical agent and carrageenan where the crosslinking pharmaceutical agent acts as a crosslinking agent to form the complex. These materials are suitable for use in ophthalmic devices and ophthalmic compositions.
A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
A61K 31/4535 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
26.
DOUBLE NETWORK HYDROGEL AND PREPARATION AND APPLICATION THEREOF
The disclosure relates to a double network hydrogel and preparation methods thereof. In particular, the disclosure relates to double network hydrogel and preparation thereof for ophthalmic devices.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/4535 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
27.
MECHANICAL DATA-BASED ACTIVATION MODE DETERMINATION OF AN ENERGY DEVICE
Systems, methods, and instrumentalities are disclosed for dynamically determining an activation mode (e.g., energy modality and/or energy level) of a surgical instrument based on monitored data. The surgical instrument may be a combination energy device capable of delivering ultrasonic energy and radiofrequency energy. The surgical instrument may monitor data associated with a surgical procedure. The surgical instrument may select an activation mode from the plurality of activation modes based on the monitored data. The surgical instrument may deliver energy of an energy modality associated with the selected activation mode. Monitored data may include visual data, electrical data, and/or mechanical data.
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
28.
COORDINATED CONTROL OF THERAPEUTIC TREATMENT EFFECTS
Devices, systems, and techniques for coordinated control of therapeutic treatment effects. An example device may select a therapeutic treatment from a database of a plurality of therapeutic treatments. The device may select a corresponding medical data stream relevant to the therapeutic treatment. The medical data stream may be produced by a surgical monitoring device. The device may determine, based on the medical data stream, qualitative feedback information about the therapeutic treatment.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
29.
CONTROL REDIRECTION AND IMAGE PORTING BETWEEN SURGICAL SYSTEMS
Systems, methods, and instrumentalities associated with shared or surrendered control (e.g., partial or full control) of a surgical system are described. Surgical systems may identify other surgical systems that support image porting and remote control. One of surgical systems may receive from another surgical system a request associated with redirection of imaging and/or a control interface to that surgical system. The surgical system may start sending imaging and/or indication of controls to the other surgical system, which may then display imaging and/or and the control interface of the first surgical system. One of the surgical systems after evaluate control settings may start monitor patient biomarker data based on the evaluated control settings. A surgical system may terminate remote control, for example, based on the patient biomarker data crossing a threshold. The surgical system may send a notification that indicates that it is taking control.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
Examples herein may allow heathcare professionals (HCPs) (e.g., surgeons) to be notified about leakage current in surgical devices. In examples, an electronic station within a surgical system may include a communications interface configured to connect to a plurality of patient monitoring devices. The electronic station may detect a leakage current associated with a patient monitoring device of the plurality of patient monitoring devices. The electronic station may determine a mechanism to compensate for the leakage current associated with the patient monitoring device. The electronic station may perform the mechanism to compensate for the leakage current associated with the patient monitoring device.
Devices, systems, and techniques for synchronized motion of independent surgical devices. An example first surgical instrument may have a movable component. The first surgical instrument may receive a motion control parameter. The motion control parameter may be one or more of: a force relative to a tissue contact shared between the first surgical instrument and the second surgical instrument; or a positional relationship between the first surgical instrument and the second surgical instrument. The first surgical instrument may sense a motion event caused by a user control input to a second surgical instrument. The first surgical instrument may autonomously adjust motion of the movable component based on the motion control parameter and the motion event.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
32.
ELECTRICAL DATA-BASED ACTIVATION MODE DETERMINATION OF AN ENERGY DEVICE
Systems, methods, and instrumentalities are disclosed for dynamically determining an activation mode (e.g., energy modality and/or energy level) of a surgical instrument based on monitored data. The surgical instrument may be a combination energy device capable of delivering ultrasonic energy and radiofrequency energy. The surgical instrument may monitor data associated with a surgical procedure. The surgical instrument may select an activation mode from the plurality of activation modes based on the monitored data. The surgical instrument may deliver energy of an energy modality associated with the selected activation mode. Monitored data may include visual data, electrical data, and/or mechanical data.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Systems, methods, and instrumentalities are disclosed for displaying a magnitude and location of a resulting tissue tension from an applied force to an instrument and a resulting tissue reaction. A surgical stapling device for monitoring and adapting to tissue tension during a surgical stapling procedure may measure strain on at least one component of the surgical stapling device resultant from one or more of an opposed force applied by a user and a force resisted by tissue associated with the tissue tension. The device may determine a location of the tissue tension based on historical surgical data, the opposed force, and the resisted force. The device may highlight the location of the tissue tension to aid in real-time surgical decision-making.
In examples, a first surgical device may be configured to detect a user operation at the first surgical device. The first surgical device may obtain data associated with the user operation. The first surgical device may determine, based on the data, whether the user operation is associated with a second surgical device separate from the first surgical device. The first surgical device may generate a control signal for controlling the second surgical device based on the determination that the user operation is associated with the second surgical device.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
35.
ADAPTIVE INTERACTION BETWEEN SMART HEALTHCARE SYSTEMS
A surgical smart system for an operating room may collect data on surgical procedures and equipment. Upon identifying specific surgical equipment, the surgical smart system may present various interaction levels—minimal, intermittent, or full. The system may dynamically choose an interaction level based on a surgical manifest and equipment use. The system may monitor the equipment's performance, adjusting interaction levels based on equipment usage patterns and its impact on patient physiology. Operational data may be displayed on an interface and archived in a database, creating a digital record of the equipment's use during surgery.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
36.
SYNCHRONIZATION OF THE OPERATIONAL ENVELOPES OF INDEPENDENT SURGICAL DEVICES
Devices, systems, and techniques for synchronization of the operational envelopes of independent surgical devices. An example device may receive a user surgical control input. The device may send an indication of a preferred operational envelope to a negotiating surgical device. The device may constrain operation responsive to the user surgical control input based on a reduced operational envelope that is determined by a response, from the negotiating surgical device, to the indication of the preferred operational envelope. The reduced operational envelope may result in a greater constraint on the operation responsive to the user surgical control input than the preferred operational envelope.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
37.
ALIGNMENT AND DISTORTION COMPENSATION OF REFERENCE PLANES USED BY SURGICAL DEVICES
Devices, systems, and techniques for a shared set of object registrations for devices with independent reference planes. An example imaging device may capture a first imaging data stream of a visualized surgical structure. The imaging device may communicate registration information with another surgical imaging device capturing a second imaging data stream of the visualized surgical structure. The imaging device may identify, based on the registration information, a first location, within the first imaging data stream, associated with the visualized surgical structure. The first location may be determinable based on: a first reference geometry associated with a field of view of the first surgical imaging device, a second reference geometry associated with a field of view of the second surgical imaging device, a transformation between the first reference geometry and the second reference geometry, and a reference landmark common to the first imaging data stream and the second imaging data stream.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
39.
METHODS FOR TREATMENT OF NON-SMALL CELL LUNG CANCER (NSCLC)
Provided are methods relating to subjects that are receiving lazertinib in a dosage of 240 mg/day, in combination with a dosage of amivantamab, in order to treat locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R substitution mutations in the subject.
Herein are methods of treating multiple myeloma in a subject comprising administering GPRC5D antibodies with enhanced antibody-dependent cellular cytotoxicity (ADCC) and enhanced complement-dependent cytotoxicity (CDC). The antibodies described in the methods are afucosylated and comprise K248E and T437R mutations (designated as "RE mutations") per the EU numbering system.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
An energy delivery device is disclosed including a cannula extendable through skin of a patient and an antenna extending from the cannula and operable to deliver energy to tissue of the patient. The antenna includes an outer conductor, a dielectric tube extending within the outer conductor, a conductor extending within the dielectric tube, and a coolant tube extending within the dielectric tube. Coolant is to be supplied through the coolant tube.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A system is disclosed including an energy delivery device and a controller. The energy delivery device includes a cannula, an antenna extending from the cannula and operable to deliver energy to tissue of the patient, and an optical sensor including Fiber Bragg Gratings (FBGs). The cannula and the antenna are insertable through skin of a patient to an insertion depth. The controller is in communication with the optical sensor and operable to receive temperature measurements from the optical sensor and determine the insertion depth based on the received temperature measurements.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
44.
PLASTIC SLEEVE WITH EMBEDDED ELECTRODE AND FLEXIBLE PCB
An apparatus for manufacturing catheter electrode-fPCB assemblies, the apparatus includes a tray, a heat source, and a sleeve molding station. The tray is configured to (i) receive an electrode in a designated first recess in a predefined layout of the recess, wherein the electrode is ring-shaped and (ii) receive a flexible printed circuit board (fPCB) strip in a second recess configured to enable to thread the fPCB strip via the electrode to a predefined position of the strip such that a pad patterned on the fPCB strip is aligned with the electrode. The heat source is configured to apply heat for soldering the pad to an inner surface of the electrode. The sleeve molding station is configured to mold an encapsulating sleeve over the electrode-fPCB assembly, while keeping a proximal end of the strip and at least a portion of the electrode exposed.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
B29C 45/14 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mouldApparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
B29K 75/00 - Use of polyureas or polyurethanes as moulding material
H05K 1/11 - Printed elements for providing electric connections to or between printed circuits
H05K 3/34 - Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits by soldering
A method for irrigation during pulsed field ablation (PFA) includes operating a pump for delivering irrigation in idle mode, receiving a first user command to deliver a PFA sequence and toggling the pump to active mode. The first PFA sequence is delivered after a pre-defined ramp-up delay, and a timer is preset to be ON for a defined working duration. A second user command to delivery a PFA sequence is received and delivered with no imposed delay while the timer is ON. The timer is reset based on the second user command. The pump is toggled to idle mode after the defined working duration lapses.
A system includes a display and a processor configured to receive an electroanatomical 3D map of cardiac chamber to be displayed on the display as a view-dependent orthographic projection. The processor is further configured to (i) receive position information of catheter located within the cardiac chamber, from catheter positioning system, (ii) define a reference point location of the catheter displayed on the map, (iii) for any given viewing direction of the map, define the viewing direction as a ray superimposed on a vector from a virtual viewer to the reference point location, (iv) calculate a view-dependent cardiac chamber distance between a distal wall location along the ray and a proximal wall location along the ray, (v) calculate a location over the ray of the reference point location relative to the cardiac chamber view-dependent distance, based on the position information, and (vi) indicate the calculated reference point location distance to user.
A method for authenticating the compatibility of a staple cartridge with a surgical instrument is disclosed. The method can comprise inserting a staple cartridge into a surgical instrument, receiving a first signal from a first RFID tag on a first component of the staple cartridge with an RFID reader system, receiving a second signal from a second RFID tag on a second component of the staple cartridge with the RFID reader system, comparing the first signal and the second signal to stored data for a compatible staple cartridge, and locking a staple firing system of the surgical instrument if the first signal and the second signal do not match the stored data for a compatible staple cartridge.
A61B 17/115 - Staplers for performing anastomosis, e.g. in a single operation
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/072 - Surgical staplers for applying a row of staples in a single action, e.g. the staples being applied simultaneously
A61B 90/96 - Identification means for patients or instruments, e.g. tags coded with symbols, e.g. text using barcodes
A61B 90/98 - Identification means for patients or instruments, e.g. tags using electromagnetic means, e.g. transponders
G06K 7/10 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation
G06K 19/077 - Constructional details, e.g. mounting of circuits in the carrier
48.
ACTUATION MECHANISMS AND LOAD ADJUSTMENT ASSEMBLIES FOR SURGICAL INSTRUMENTS
An ultrasonic surgical instrument includes an inner tube, an outer tube, an ultrasonic blade, and a clamp member pivotably moveable relative to the ultrasonic blade. The ultrasonic blade is acoustically coupled to an ultrasonic transducer. The clamp member pivotably movable relative to the ultrasonic blade between an open configuration and an approximated configuration with respect to the ultrasonic blade, wherein the clamp member is pivotably coupled to the inner tube, wherein the clamp member is pivotably coupled to the outer tube, and wherein movement of the outer tube relative to the inner tube between the first position and the second position transitions the clamp member between the open configuration and the approximate configuration.
A61B 17/29 - Forceps for use in minimally invasive surgery
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
49.
PHACOEMULSIFICATION PROBE COMPRISING MAGNETIC SENSORS AND/OR MULTIPLE INDEPENDENT PIEZOELECTRIC VIBRATORS
A phacoemulsification device includes a phacoemulsification probe and a processor. The phacoemulsification probe includes a piezoelectric crystal configured to vibrate in response to a drive signal, a needle configured to be inserted into a lens capsule of an eye and to be vibrated by the piezoelectric crystal, and a set of magnetic-field components. The set includes (i) one or more magnetic-field generators configured to generate a magnetic field, and (ii) one or more magnetic-field sensors configured to sense the magnetic field. At least one of the magnetic-field components is coupled to vibrate with the needle and at least one other of the magnetic-field components is isolated from vibration of the needle, thereby causing the magnetic-field sensors to output signals indicative of the vibration. The processor is configured to adaptively adjust a frequency of the drive signal so as to vibrate the needle at a resonant frequency of the piezoelectric crystal.
Systems, methods, and instrumentalities are disclosed for dynamically determining an activation mode (e.g., energy modality and/or energy level) of a surgical instrument based on monitored data. The surgical instrument may be a combination energy device capable of delivering ultrasonic energy and radiofrequency energy. The surgical instrument may monitor data associated with a surgical procedure. The surgical instrument may select an activation mode from the plurality of activation modes based on the monitored data. The surgical instrument may deliver energy of an energy modality associated with the selected activation mode. Monitored data may include visual data, electrical data, and/or mechanical data.
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
51.
SYNCHRONIZED MOTION OF INDEPENDENT SURGICAL DEVICES TO MAINTAIN RELATIONAL FIELD OF VIEWS
Devices, systems, and techniques for synchronized motion of independent surgical devices to maintain relational field of views. A first imaging device may receive a video data stream captured by a second imaging device. The first imaging device may be located on a first side of an anatomical barrier and the second imaging device may be located on a second side of the anatomical barrier. The first side and the second side may be opposing sides of the anatomical barrier. The first imaging device may determine, based on the video data stream, a coupled field of view between the first imaging device and the second imaging device. The first imaging device may determine, based on the video data stream, that the second imaging device has moved. The first imaging device may adjust an imaging parameter of the first imaging device to maintain the coupled field of view.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/313 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
52.
FUNCTIONAL RESTRICTION OF A SYSTEM BASED ON INFORMATION FROM ANOTHER INDEPENDENT SYSTEM
Devices, systems, and techniques for functional restriction of a device based on information from another independent system. An example first surgical device may determine that the first surgical device is capable of obtaining medical information from a second surgical device. The first surgical device may receive the medical information from the second surgical device. The first surgical device may determine that the medical information satisfies a condition. Determining that the medical information satisfies a condition may involve determining that operation of the first surgical device and operation of the second surgical device have created a negative feedback loop that negatively impacts patient health. The first surgical device may limit functional capabilities of the first surgical device based on the medical information satisfying the condition.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
53.
INTER-CONNECTIVITY OF DATA FLOWS BETWEEN INDEPENDENT SMART SYSTEMS
Systems, methods, and instrumentalities associated with inter-connectivity of data flows between various surgical devices and/or systems are disclosed. The surgical devices and/or surgical systems may be interrelated or independent smart surgical devices and/or surgical systems. Data sourced by a first surgical device/system may be communicated to and/or accessible by a second surgical device/system for interactive use and storage. The data exchange may be bi-directional or unidirectional, which, for example, may enable the surgical devices/systems to interface and use each other's data. The data exchange may affect one or multiple surgical device/system's operation.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
54.
INTER-CONNECTIVITY OF DATA FLOWS BETWEEN INDEPENDENT SMART SYSTEMS
Systems, methods, and instrumentalities associated with adaptation of operation associated with monitoring of surgical devices. A first surgical device may monitor operation of a second surgical device. The monitoring of the second surgical device may affect the operation of the first surgical device (e.g., impact data generation). The first surgical device or the second surgical device may change its operating configuration, for example, based on the monitoring.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
55.
METHOD FOR ACTIVATION MODE DETERMINATION OF AN ENERGY DEVICE
Systems, methods, and instrumentalities are disclosed for dynamically determining an activation mode (e.g., energy modality and/or energy level) of a surgical instrument based on monitored data. The surgical instrument may be a combination energy device capable of delivering ultrasonic energy and radiofrequency energy. The surgical instrument may monitor data associated with a surgical procedure. The surgical instrument may select an activation mode from the plurality of activation modes based on the monitored data. The surgical instrument may deliver energy of an energy modality associated with the selected activation mode. Monitored data may include visual data, electrical data, and/or mechanical data.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
56.
MULTI-SOURCED DATA-BASED ACTIVATION MODE DETERMINATION OF AN ENERGY DEVICE
Systems, methods, and instrumentalities are disclosed for dynamically determining an activation mode (e.g., energy modality and/or energy level) of a surgical instrument based on monitored data. The surgical instrument may be a combination energy device capable of delivering ultrasonic energy and radiofrequency energy. The surgical instrument may monitor data associated with a surgical procedure. The surgical instrument may select an activation mode from the plurality of activation modes based on the monitored data. The surgical instrument may deliver energy of an energy modality associated with the selected activation mode. Monitored data may include visual data, electrical data, and/or mechanical data.
Systems, methods, and instrumentalities are disclosed for dynamically determining an activation mode (e.g., energy modality and/or energy level) of a surgical instrument based on monitored data. The surgical instrument may be a combination energy device capable of delivering ultrasonic energy and radiofrequency energy. The surgical instrument may monitor data associated with a surgical procedure. The surgical instrument may select an activation mode from the plurality of activation modes based on the monitored data. The surgical instrument may deliver energy of an energy modality associated with the selected activation mode. Monitored data may include visual data, electrical data, and/or mechanical data.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
Discussed herein are pharmaceutical compositions containing Ibrutinib and processes for preparing them. The compositions may be utilized in the treatment of a variety of conditions including, without limitation, B-cell proliferative disorders such as non-Hodgkin lymphoma (diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma or burkitt lymphoma), Waldenstrom macroglobulinemia, plasma cell myeloma, chronic lymphocytic leukemia, lymphoma, or leukemia. These compositions are designed for oral ingestion. The compositions are contained within a capsule such as a standard or sprinkle or in a liquid formulation such as a suspension. In one embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. In another embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, carboxymethylcellulose sodium, hydroxypropylmethylcellulose, citric acid monohydrate, disodium hydrogen phosphate, sucralose, sodium methyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, concentrated hydrochloric acid, sodium hydroxide, and water.
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
A23L 33/16 - Inorganic salts, minerals or trace elements
A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
A61K 9/00 - Medicinal preparations characterised by special physical form
B01J 2/10 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic in stationary drums or troughs, provided with kneading or mixing appliances
B01J 2/22 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
60.
REPLACEABLE SURGICAL SCISSOR BLADES FOR SURGICAL INSTRUMENTS
A surgical tool includes a drive housing, a plurality of capstan assemblies arranged within the drive housing, a plurality of drive cables operatively coupled to and extending from the plurality of capstan assemblies. At least one capstan assembly includes a drive gear, and a driven gear arranged to intermesh with the drive gear and including a cable pulley configured to receive an end of a corresponding one of the plurality of drive cables. The surgical tool further includes a rotation limiter system mounted within the drive housing and actuatable between a blocking position, in which the rotation limiter system physically prevents the drive gear from rotating in a first angular direction to a predetermined angular position, and an unobstructed position, in which the rotation limiter system moves and thereby allows the drive gear to rotate to the predetermined angular position.
Provided are methods relating to subjects that are receiving lazertinib in a dosage of 240 mg/day, in combination with a dosage of amivantamab, in order to treat locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 L858R substitution mutations in the subject.
An apparatus includes a body, a shaft assembly, and an end effector. The shaft assembly includes an outer shaft and two elongate members. A first portion of the first elongate member is positioned within a recess of the second elongate member, while a second portion of the first elongate member is laterally offset relative to the second elongate member. A first portion of the second elongate member is positioned within a recess of the first elongate member, while a second portion of the second elongate member is laterally offset relative to the first elongate member. The end effector includes a first component coupled with the first elongate member and a second a second component coupled with the second elongate member, such that the first and second elongate members are operable to drive movement of the respective first and second components of the end effector.
A method of treating psoriatic arthritis, comprises administering an IL-23 inhibitor, such as an anti-IL-23p19 antibody (e.g., guselkumab) and a TNF-α inhibitor, such as an anti-TNF-α antibody (e.g., golimumab).
C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
A61P 37/00 - Drugs for immunological or allergic disorders
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
64.
BISPECIFIC ANTIBODY TARGETING HK2 AND CD3 FOR THE TREATMENT OF PROSTATE CANCER
The present invention relates to methods of treating prostate cancer in a subject in need thereof, comprising administering a therapeutically effective amount of a KLK2xCD3 bispecific antibody or bispecific binding fragment thereof to the subject to treat the prostate cancer.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
Provided herein are several embodiments of a dexterity tool for opening a contact lens package to remove a contact lens inside. Some embodiments may have a housing which clamps down on the contact lens package to aid in the removal of the lid from the contact lens package. Some embodiments may also have a top clamshell housing with a movable jaw connected to the top clamshell housing and an opening in the top clamshell housing. Some embodiments may also include a bottom clamshell housing hingedly attached to the top clamshell housing so that the top housing hinges about a hinge axis relative to the bottom housing and further contains a bowl positioned within the bottom clamshell housing and a platform surrounding the bowl. A fixed jaw may be connected to the platform such that when the tool is placed in a closed position the contact lens package is sandwiched in between the movable jaw and the fixed jaw.
An apparatus includes a body, a shaft assembly, and an end effector. The shaft assembly includes an outer shaft and two elongate members. A first portion of the first elongate member is positioned within a recess of the second elongate member, while a second portion of the first elongate member is laterally offset relative to the second elongate member. A first portion of the second elongate member is positioned within a recess of the first elongate member, while a second portion of the second elongate member is laterally offset relative to the first elongate member. The end effector includes a first component coupled with the first elongate member and a second a second component coupled with the second elongate member, such that the first and second elongate members are operable to drive movement of the respective first and second components of the end effector.
An apparatus includes a body, a shaft assembly, and an end effector. The shaft assembly includes an outer shaft and a knife assembly. The knife assembly includes an elongate body and a beam. At least a portion of the body is slidably positioned within a hollow interior of the outer shaft. The beam extends distally from the distal end of the body. The beam includes a proximal portion positioned within the body and thereby secured to the body. The beam further includes a distal portion having a knife that is operable to sever tissue. The end effector includes a first jaw and a second jaw. The first jaw is movable relative to the second jaw between an open position and a closed position. The knife is operable to translate along one or both of the first jaw or the second jaw.
An apparatus includes a body, a shaft assembly, and an end effector. The shaft assembly includes an inner guide having a laterally facing surface and a distally facing surface. The end effector includes a first jaw and a second jaw. The first jaw is movable toward and away from the second jaw. The second jaw includes a first proximally projecting beam. The first proximally projecting beam is positioned and configured to engage the laterally facing surface of the inner guide to thereby establish and maintain a predetermined angular position of the end effector relative to the shaft assembly. The first proximally projecting beam is further positioned and configured to engage the distally facing surface of the inner guide to thereby establish and maintain a predetermined longitudinal position of the end effector relative to the shaft assembly.
A surgical computing system may receive measurement data from at least one sensing system. The measurement data may be associated with a set of patient biomarkers of a patient. A surgical computing system may obtain a set of patient parameters associated with the patient. A surgical computing system may generate vectorized patient data based on at least the measurement data and a set of patient-specific parameters. A surgical computing system may use a predictive model to predict an occurrence of a prolonged air leak (PAL) based at least on the vectorized patient data. A surgical computing system may generate a set of recommendations for preventing the PAL.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
71.
TRANSFERRIN RECEPTOR BINDING PROTEINS FOR TREATING BRAIN TUMORS
Provided are novel multispecific antibodies comprising at least one of a first antigen-binding region and a second antigen-binding region each capable of binding specifically to human epidermal growth factor receptor 2 (HER2), and a third antigen-binding region capable of binding specifically to transferrin receptor (TfR).
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
A61K 39/00 - Medicinal preparations containing antigens or antibodies
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
The present application provides an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein (for example, PSA or hK2) for use in the treatment of prostate cancer, and a method for the treatment of prostate cancer in a patient, the method comprising the step of administering a therapeutically effective amount of an agent comprising or consisting of a binding moiety with specificity for a kallikrein protein to the patient.
A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
73.
MEDICAL INSTRUMENT KNIFE ASSEMBLY WITH BEAM AND OVERMOLD
An apparatus includes a body, a shaft assembly, and an end effector. The shaft assembly includes an outer shaft and a knife assembly. The knife assembly includes an elongate body and a beam. At least a portion of the body is slidably positioned within a hollow interior of the outer shaft. The beam extends distally from the distal end of the body. The beam includes a proximal portion positioned within the body and thereby secured to the body. The beam further includes a distal portion having a knife that is operable to sever tissue. The end effector includes a first jaw and a second jaw. The first jaw is movable relative to the second jaw between an open position and a closed position. The knife is operable to translate along one or both of the first jaw or the second jaw.
An apparatus includes a body, a shaft assembly, and an end effector (200). The shaft assembly includes an inner guide (130) having a laterally facing surface (140) and a distally facing surface (138). The end effector includes a first jaw and a second jaw. The first jaw is movable toward and away from the second jaw. The second jaw includes a first proximally projecting beam (256a, b). The first proximally projecting beam is positioned and configured to engage the laterally facing surface of the inner guide to thereby establish and maintain a predetermined angular position of the end effector relative to the shaft assembly. The first proximally projecting beam is further positioned and configured to engage the distally facing surface of the inner guide to thereby establish and maintain a predetermined longitudinal position of the end effector relative to the shaft assembly.
The present invention relates to methods of reducing occurrence or severity of infusion-related reactions (IRRs) in a subject treated with an anti-epidermal growth factor receptor (EGFR)/hepatocyte growth factor receptor (c-Met) antibody, comprising administering (a) dexamethasone; (b) montelukast; or (c) methotrexate to the subject.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 39/00 - Medicinal preparations containing antigens or antibodies
76.
METHODS FOR REDUCING DERMATOLOGIC ADVERSE EVENTS IN PATIENTS TREATED WITH EGFR/MET BISPECIFIC ANTIBODIES
The present invention relates to methods of reducing occurrence or severity of dermatologic adverse events (DAEs) in a subject treated with an anti-epidermal growth factor receptor (EGFR)/hepatocyte growth factor receptor (c-Met) antibody and EGFR tyrosine kinase inhibitor, comprising (a) administering an antibiotic(s); (b) administering an antiseptic(s); and (c) administering a non-comedogenic moisturizer to the subject.
Bone anchors and surgical instruments (e.g., bone taps, drivers, etc.) are disclosed herein that include integrated guide tips. Use of these anchors or instruments can eliminate one or more of the steps in a conventional bone anchor installation procedure, improving surgical efficiency and safety. For example, a surgical instrument can include a guide projection configured for insertion through a cannulation formed in a bone anchor when the surgical instrument is coupled to the bone anchor. The surgical instrument can also include various mechanisms for adjusting the position of the guide projection relative to the bone anchor. The guide projection can replace the needle, stylet, and guidewire used in typical insertion procedures. The bone anchor can also include integrated tapping features to eliminate the need for a separate bone tap instrument. Thus, in some embodiments, targeting, tapping, and driving the bone anchor can be performed in a single step.
A61B 17/88 - Methods or means for implanting or extracting internal fixation devices
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A surgical system is herein disclosed that includes a surgical instrument and a generator. The surgical instrument includes a handle assembly that is grasped by one or more hands of an operator, a shaft assembly connected to the handle assembly, an arm, an end effector connected to the shaft assembly that interacts with tissue, and a sensor that senses a characteristic of the arm, from which an amount of pressure experienced by the arm while the end effector interacts with the tissue is determined. The generator is connected to the surgical instrument and delivers, to the end effector, a power profile dynamically selected from a plurality of power profiles based on the determined amount of pressure experienced by the arm.
Systems and methods are described for a surgical instrument. Certain embodiments can comprise an end effector with upper and lower jaws that can compress tissue therebetween. A sensing probe with a sensing electrode can be extended along the surface of the tissue in a track located within one of the jaws. The sensing electrode can be configured to detect location or type of tissue. Once position, size, or other factors are known about the tissue, a knife member can be deployed in the track or a separate track with increased accuracy and precision.
A surgical system may include tiered-access features. The surgical system may be used to analyze at least a portion of a surgical field. Based on a control parameter, the system may scale up or down various capabilities, such as visualization processing, endocutter communication, endocutter algorithm updates, smart cartridge connectivity, smart motor control for circular stapler, smart energy control, cloud analytics, hub connectivity control, and/or hub visualization and control interactions. The control parameter may include system aspects such as processing capability or bandwidth for example and/or the identification of an appropriate service tier.
A61B 17/115 - Staplers for performing anastomosis, e.g. in a single operation
A61B 17/00 - Surgical instruments, devices or methods
A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/92 - Identification means for patients or instruments, e.g. tags coded with colour
A61B 90/98 - Identification means for patients or instruments, e.g. tags using electromagnetic means, e.g. transponders
83.
METHODS FOR TREATING MULTIPLE MYELOMA WITH CAR-T CELLS AND BISPECIFIC ANTIBODIES
Provided herein are methods of treating cancer in a subject in need thereof by administering an anti-BCMA CAR-T cell and a GPRC5D×CD3 bispecific antibody. In some embodiments, the subject has relapsed and/or refractory multiple myeloma. In some embodiments, the subject has received at least one prior line of therapy. In some embodiments, the subject has newly diagnosed multiple myeloma and is transplant ineligible.
A surgical system is herein disclosed that includes a surgical instrument and a generator. The surgical instrument includes a handle assembly that is grasped by one or more hands of an operator, a shaft assembly connected to the handle assembly, an arm, an end effector connected to the shaft assembly that interacts with tissue, and a sensor that senses a characteristic of the arm, from which an amount of pressure experienced by the arm while the end effector interacts with the tissue is determined. The generator is connected to the surgical instrument and delivers, to the end effector, a power profile dynamically selected from a plurality of power profiles based on the determined amount of pressure experienced by the arm.
A61B 17/29 - Forceps for use in minimally invasive surgery
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Provided herein are methods of treating an autoimmune disease in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of an anti-BCMA therapeutic.
A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
86.
METHODS AND COMPOSITIONS FOR MODULATING BETA CHAIN MEDIATED IMMUNITY
The present disclosure relates to bispecific molecules targeting V017 and DLLS, nucleic acids and expression vectors encoding said molecules, recombinant cells containing the vectors, and compositions comprising the molecules. Methods of making the antibodies, and methods of using the antibodies to kill cancer cells, are also provided.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
87.
N-VINYL OXAZOLIDINONE MONOMERS, POLYMERS THEREFROM, AND USE IN OPHTHALMIC DEVICES
Provided are N-vinyl oxazolidinone monomers; polymers and polymeric networks made therefrom; and the use of these materials in ophthalmic devices and/or packaging solutions for ophthalmic devices, such as contact lenses. The N-vinyl oxazolidinone monomers are of formula (I):
Provided are N-vinyl oxazolidinone monomers; polymers and polymeric networks made therefrom; and the use of these materials in ophthalmic devices and/or packaging solutions for ophthalmic devices, such as contact lenses. The N-vinyl oxazolidinone monomers are of formula (I):
Provided are N-vinyl oxazolidinone monomers; polymers and polymeric networks made therefrom; and the use of these materials in ophthalmic devices and/or packaging solutions for ophthalmic devices, such as contact lenses. The N-vinyl oxazolidinone monomers are of formula (I):
wherein R1, R2, R3, R4, and R5 are as defined herein.
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
C08F 283/12 - Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass on to polysiloxanes
Described are multifocal contact lenses that contain high energy visible (HEV) light absorbing compounds and their use for improving one or more vision attributes.
An aneurysm intrasaccular implant is provided having both a braid section and a coil. The braid section is expandable from a collapsed configuration to an expanded configuration. The coil includes a proximal coil segment extending proximally from the braid section and a distal coil segment extending distally from the braid section. The implant further includes an engagement member both movable within and confined within the braid section. The engagement member is attached to one or more of the proximal coil segment or the distal coil segment.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
90.
FLEXIBLE MICROWAVE ABLATION DEVICE WITH DISTAL INFLATABLE BALLOON
A surgical system is disclosed including a probe and a balloon operatively coupled to the probe. The probe includes a shaft, an antenna extending from the shaft, and a conductor extending through the antenna and operable to deliver energy to tissue of a patient. The balloon is transitionable between an inflated state and a deflated state. In the inflated state, the balloon maintains a position of the antenna relative to the tissue and enhances energy delivery from the conductor to the tissue.
Methods and systems are provided for training machine learning (e.g., NN) or other artificial intelligence (AI) models to control a robot arm to manipulate a catheter to robotically perform an invasive clinical catheter-based procedure.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
92.
STEREO CHIP-ON-TIP ENDOSCOPE SUITABLE FOR AUTOCLAVE STERILIZATION
Endoscope assembly suitable for repeated re-processing utilizing autoclave sterilization techniques. An endoscope includes a handpiece and an insertion tube attached to the handpiece, wherein the insertion tube comprises a sidewall, and wherein the sidewall comprises an interior surface and an exterior surface. The endoscope includes a cover plate attached to the interior surface of the sidewall of the insertion tube, and a window attached to the cover plate. The endoscope includes a fiber optic ferrule disposed within the insertion tube, wherein the fiber optic ferrule is configured to receive a distal fiber optic bundle, wherein the fiber optic ferrule is attached to the cover plate at the illumination hole such that electromagnetic radiation transmitted by the distal fiber optic bundle passes through the illumination hole of the cover plate.
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
Disclosed in an accessory circuit for a modular energy system. The accessory circuit includes an accessory port configured to receive an accessory, a power supply, a processor, an isolation barrier configured to electrically isolate the processor and the power supply from the accessory port. A flexible serial communication interface is coupled between the processor and the accessory port. The flexible serial communication interface is configured to support multiple communication protocols. A presence detection circuit is coupled between the accessory port and the processor. The presence detection circuit is configured to detect presence of an accessory connected to the accessory port.
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
G06F 1/3234 - Power saving characterised by the action undertaken
Endoscope assembly suitable for repeated re-processing utilizing autoclave sterilization techniques. An endoscope includes a handpiece and an insertion tube attached to the handpiece, wherein the insertion tube comprises a sidewall, and wherein the sidewall comprises an interior surface and an exterior surface. The endoscope includes a cover plate attached to the interior surface of the sidewall of the insertion tube, and a window attached to the cover plate. The endoscope includes a fiber optic ferrule disposed within the insertion tube, wherein the fiber optic ferrule is configured to receive a distal fiber optic bundle, wherein the fiber optic ferrule is attached to the cover plate at the illumination hole such that electromagnetic radiation transmitted by the distal fiber optic bundle passes through the illumination hole of the cover plate.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/05 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
95.
END EFFECTOR WITH TISSUE POSITION SENSOR AND RELATED METHODS
Systems and methods are described for a surgical instrument. Certain embodiments can comprise an end effector with upper and lower jaws that can compress tissue therebetween. A sensing probe with a sensing electrode can be extended along the surface of the tissue in a track located within one of the jaws. The sensing electrode can be configured to detect location or type of tissue. Once position, size, or other factors are known about the tissue, a knife member can be deployed in the track or a separate track with increased accuracy and precision.
A61B 17/295 - Forceps for use in minimally invasive surgery combined with cutting implements
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 17/29 - Forceps for use in minimally invasive surgery
96.
DOSES AND PHARMACEUTICAL COMPOSITIONS OF A CD33 X Vδ2 BISPECIFIC ANTIBODY FOR THE TREATMENT OF CANCER
The present disclosure relates to doses and dosing regimens of a bispecific antibody that binds myeloid cell surface antigen CD33, and the Vδ2 chain of the human Vγ9Vδ2 T cell receptor; to pharmaceutical compositions comprising said antibodies, as well as methods of administration of the referred doses, and to the use of said antibodies in the treatment of Acute Myeloid Leukemia (AML) or Myelodysplastic Neoplasms (MDS), in particular Relapsed or Refractory (R/R) AML or MDS.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
