Abrégé

The nanoprinting method consists in a device (1) for applying nanoparticles (4) to surface of a substrate (7), where nanoparticles (4) are prepared in a gas aggregation source (3) connected through an exit orifice (11) into a vacuum chamber (2). Nanoparticles (4) are supplied into vacuum chamber (2) in the form of a beam. The device (1) includes a light source (5) generating a light beam (9) for selective sintering of nanoparticles (4). The light beam (9) is focused on the exposure region (20) lying in the plane of the surface of the substrate (7) with nanoparticles (4). The device (1) includes a focusing optical element (8) which focuses the light beam (9) on the exposure region (20) lying in the plane of the surface of the substrate (7). The position of the substrate (7) relative to the light beam (9) changes mutually using a positioning device (12).

Classes IPC  ?

• B22F 10/20 - Frittage ou fusion directs
• B22F 12/33 - Plate-formes ou substrats de translation dans le plan de dépôt
• B22F 1/054 - Particules de taille nanométrique
• C23C 14/35 - Pulvérisation cathodique par application d'un champ magnétique, p. ex. pulvérisation au moyen d'un magnétron
• B22F 9/12 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un produit gazeux
• B22F 1/17 - Particules métalliques revêtues de métal
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
• C23C 14/24 - Évaporation sous vide
• B22F 9/08 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un matériau liquide par coulée, p. ex. à travers de petits orifices ou dans l'eau, par atomisation ou pulvérisation

Abrégé

Pharmaceutical combination for use in the treatment of cancer The object of the present invention is a pharmaceutical combination of active substances which comprises at least one TLR ligand, at least one compound that labels tumor cells as a target for immune cell attack and at least one anti-CD40 antibody, and further at least one inhibitor of glutamine metabolism. The use of the pharmaceutical combination is for cancer treatment, especially for solid tumor treatments as pancreatic adenocarcinoma.

Classes IPC  ?

• A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
• A61K 31/395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines
• A61K 31/41 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec plusieurs hétéro-atomes cycliques, l'un au moins étant l'azote, p. ex. tétrazole
• A61K 31/42 - Oxazoles
• A61K 31/4355 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'oxygène comme hétéro-atome du cycle
• A61K 31/473 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. acridines, phénantridines
• A61K 31/655 - Composés azoïques(-N=N-), diazoïques (=N2), azoxy (N-O-N ou N(=O)-N), azido (-N3) ou diazoamino (-N=N-N)
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• A61K 31/719 - Pullulanes
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux

Abrégé

The aeration and oxygenation equipment intended in particular for fish farm tanks (2) brings the possibility of aeration and oxygenation of water in a fish farm tank (2) without a need for a heavy weight and or any obstacles to fish harvesting. The fish farm tank (2) is fitted with a special thin-walled aeration adapter (1) with oxygenation which is not self-supporting but copies the walls (12) and bottom (11) of the fish farm tank (2). Under the bottom (13) of the aeration adapter (1) in the central part two distributing aeration rings (3, 3´) and one distributing oxygenation ring (4) are placed. The bottom (13) of the aeration adapter (1) is above the distributing aeration rings (3, 3´) and the distributing oxygenation ring (4) perforated by aeration openings (16) and oxygenation openings (17), through which air and oxygen bubbles are released into the fish farm tank (2).

Classes IPC  ?

• A01K 63/04 - Agencements pour traiter l'eau spécialement conçus pour les récipients pour poissons vivants
• A01K 97/20 - Bourriches ou autres récipients pour garder des poissons capturés

Abrégé

The invention pertains to a method of obtaining structural and functional information on proteins, based on polarization fluorescence microscopy, which comprises subjecting a protein tagged with a fluorophore to two- or multi-photon fluorescence microscopy, whereas the observed protein is irradiated with a laser beam with light of at least two different polarizations, which excites the fluorescence of the fluorophore, and wherein information on localization, intensities and polarizations of the fluorescence excited by the different polarizations of the excitation laser beam is used to identify, localize and quantify anisotropy of absorption and/or fluorescence, which information is then used to infer structural and functional properties of proteins. An example of a device for obtaining structural and functional information on proteins, based on polarization fluorescence microscopy, comprises a modulator (P) for rapid modulation of the excitation beam (1) for eliciting two- or multi-photon fluorescence, and a control unit (R), wherein the function of the modulator (P) and control unit (R) is synchronized with scanning of the microscope (M) such that information on fluorescence intensity acquired by the microscope (M) is attributable to a particular polarization state of the excitation beam (1) by virtue of knowing the temporal profile of the polarization modulation of the excitation beam (1) effected by the modulator (P). The method and device of the invention allow determining and monitoring structure and function of proteins, such as membrane proteins, and thereby observing physiological processes in living cells.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes

Abrégé

The concentrate of potato tuber proteins with high re-solubility has the re-soluble part at least 75 % and the predominant part of proteins presented in the concentrate is in native form and shows characteristics of biological activity. The concentrate contains regulator of acidity, with advantage NaOH, in amount necessary for reaching of pH of dissolved concentrate ranging between 6.8 and 7.5. The concentrate has reduced contents of glycoalkaloids and other ballast matters. The concentrate is prepared from centrifuged, cooled potato fruit juice with adjusted pH by adding of precipitation additive that is cooled ethanol. Subsequently the resulted protein isolate is washed and preserved for final usage of the protein concentrate in food industry and biotechnological applications.

Classes IPC  ?

• A23J 1/16 - Préparation des compositions à base de protéines pour l'alimentationOuverture des œufs par grandes quantités et séparation du jaune du blanc à partir des eaux résiduaires des fabriques d'amidon ou de résidus analogues
• A23J 3/14 - Protéines végétales