Abstract

The nanoprinting method consists in a device (1) for applying nanoparticles (4) to surface of a substrate (7), where nanoparticles (4) are prepared in a gas aggregation source (3) connected through an exit orifice (11) into a vacuum chamber (2). Nanoparticles (4) are supplied into vacuum chamber (2) in the form of a beam. The device (1) includes a light source (5) generating a light beam (9) for selective sintering of nanoparticles (4). The light beam (9) is focused on the exposure region (20) lying in the plane of the surface of the substrate (7) with nanoparticles (4). The device (1) includes a focusing optical element (8) which focuses the light beam (9) on the exposure region (20) lying in the plane of the surface of the substrate (7). The position of the substrate (7) relative to the light beam (9) changes mutually using a positioning device (12).

IPC Classes  ?

• B22F 10/20 - Direct sintering or melting
• B22F 12/33 - Platforms or substrates translatory in the deposition plane
• B22F 1/054 - Nanosized particles
• C23C 14/35 - Sputtering by application of a magnetic field, e.g. magnetron sputtering
• B22F 9/12 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using physical processes starting from gaseous material
• B22F 1/17 - Metallic particles coated with metal
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 30/00 - Apparatus for additive manufacturingDetails thereof or accessories therefor
• C23C 14/24 - Vacuum evaporation
• B22F 9/08 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using physical processes starting from liquid material by casting, e.g. through sieves or in water, by atomising or spraying

Abstract

Pharmaceutical combination for use in the treatment of cancer The object of the present invention is a pharmaceutical combination of active substances which comprises at least one TLR ligand, at least one compound that labels tumor cells as a target for immune cell attack and at least one anti-CD40 antibody, and further at least one inhibitor of glutamine metabolism. The use of the pharmaceutical combination is for cancer treatment, especially for solid tumor treatments as pancreatic adenocarcinoma.

IPC Classes  ?

• A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/41 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
• A61K 31/42 - Oxazoles
• A61K 31/4355 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
• A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61K 31/655 - Azo (—N=N—), diazo (=N2), azoxy (N—O—N or N(=O)—N), azido (—N3) or diazoamino (—N=N—N) compounds
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 31/719 - Pullulans
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents

Abstract

The aeration and oxygenation equipment intended in particular for fish farm tanks (2) brings the possibility of aeration and oxygenation of water in a fish farm tank (2) without a need for a heavy weight and or any obstacles to fish harvesting. The fish farm tank (2) is fitted with a special thin-walled aeration adapter (1) with oxygenation which is not self-supporting but copies the walls (12) and bottom (11) of the fish farm tank (2). Under the bottom (13) of the aeration adapter (1) in the central part two distributing aeration rings (3, 3´) and one distributing oxygenation ring (4) are placed. The bottom (13) of the aeration adapter (1) is above the distributing aeration rings (3, 3´) and the distributing oxygenation ring (4) perforated by aeration openings (16) and oxygenation openings (17), through which air and oxygen bubbles are released into the fish farm tank (2).

IPC Classes  ?

• A01K 63/04 - Arrangements for treating water specially adapted to receptacles for live fish
• A01K 97/20 - Keepnets or other containers for keeping captured fish

Abstract

The invention pertains to a method of obtaining structural and functional information on proteins, based on polarization fluorescence microscopy, which comprises subjecting a protein tagged with a fluorophore to two- or multi-photon fluorescence microscopy, whereas the observed protein is irradiated with a laser beam with light of at least two different polarizations, which excites the fluorescence of the fluorophore, and wherein information on localization, intensities and polarizations of the fluorescence excited by the different polarizations of the excitation laser beam is used to identify, localize and quantify anisotropy of absorption and/or fluorescence, which information is then used to infer structural and functional properties of proteins. An example of a device for obtaining structural and functional information on proteins, based on polarization fluorescence microscopy, comprises a modulator (P) for rapid modulation of the excitation beam (1) for eliciting two- or multi-photon fluorescence, and a control unit (R), wherein the function of the modulator (P) and control unit (R) is synchronized with scanning of the microscope (M) such that information on fluorescence intensity acquired by the microscope (M) is attributable to a particular polarization state of the excitation beam (1) by virtue of knowing the temporal profile of the polarization modulation of the excitation beam (1) effected by the modulator (P). The method and device of the invention allow determining and monitoring structure and function of proteins, such as membrane proteins, and thereby observing physiological processes in living cells.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• G02B 21/00 - Microscopes

Abstract

The concentrate of potato tuber proteins with high re-solubility has the re-soluble part at least 75 % and the predominant part of proteins presented in the concentrate is in native form and shows characteristics of biological activity. The concentrate contains regulator of acidity, with advantage NaOH, in amount necessary for reaching of pH of dissolved concentrate ranging between 6.8 and 7.5. The concentrate has reduced contents of glycoalkaloids and other ballast matters. The concentrate is prepared from centrifuged, cooled potato fruit juice with adjusted pH by adding of precipitation additive that is cooled ethanol. Subsequently the resulted protein isolate is washed and preserved for final usage of the protein concentrate in food industry and biotechnological applications.

IPC Classes  ?

• A23J 1/16 - Obtaining protein compositions for foodstuffsBulk opening of eggs and separation of yolks from whites from waste water of starch-manufacturing plant or like wastes
• A23J 3/14 - Vegetable proteins