A compound having the structure (I), (II), (III), or (IV) is provided: (I), (II), (III), (IV) ) where in these structures, (I), (II), (III), and (IV), each R14100100 groups optionally substituted with one or more of alkenyl, alkynyl, hydroxyl, amide, ester, and/or ether groups; R222pp or (A); R3is selected from Formula (V) and Formula (VI): (V, (VI). M+ is selected from an alkali metal ion, an alkaline earth metal ion, or a primary, secondary or tertiary ammonium ion; and m, p, and s are independently selected from integers from 1 to 120. The compound is useful as a liver asialoglycoprotein receptor-targeted therapeutic agent in the form of a lipid nanoparticle, a liposome or a micelle including a drug or oligonucleotide.
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
C07H 15/00 - Composés contenant des radicaux hydrocarbonés ou hydrocarbonés substitués, liés directement aux hétéro-atomes des radicaux saccharide
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
Chemical compounds for scientific or research use in vitro studies to test the effects of potential drug compounds on biological targets; adjuvants for scientific or research use, other than for medical or veterinary purposes; chemical reagents for the delivery of lipids for scientific or research use; chemical compounds for use as standards solutions for use with analytical techniques, namely, mass spectrometry; compounds for scientific or research use, namely, lipids, synthetic lipids, polymer modified lipids, lipids with modified head groups, lipids with modified acyl chains, bioactive lipids, fluorescent lipids, isotope labeled lipids, oxidized lipids, sphingolipids, lipid extracts from natural sources, lipids conjugated with modified gold particles; compounds for scientific or research use, namely, fatty acids, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, sterol lipids, prenol lipids, lipid preparations suitable for protein crystallization, lipid preparations suitable for protein solubilization, detergents, amphiphilic detergents, and antibodies; diagnostic reagents and analytical reagents for scientific or research use; formulations comprising lipids for scientific or research use; enzymes for scientific or research use; lipids, chemical additives, and excipients for use in the manufacture of pharmaceutical preparations Chemical compounds for pharmaceutical or medical use, namely, drug delivery agents being excipients for small molecule, protein drug delivery, and adjuvants for vaccines; adjuvants for medical use; immunostimulatory compounds for medical use; medical diagnostic reagents; medical diagnostic test strips for the detection of bacterial infections for medical use; isotopes for medical use Current good manufacturing practice (cGMP) custom manufacture of active agents and additives for others; Current good manufacturing practice (cGMP) custom manufacture of lipids for others; custom manufacturing services for others in the field of active agents, additives, or excipients in pharmaceutical preparations; custom manufacturing services for others in the field of lipids; providing information on chemical manufacturing relating to lipids and related compounds for scientific and medical research purposes
3.
UNIVERSAL LIPID QUANTITATIVE STANDARDS FOR USE IN LIPIDOMICS
The present disclosure provides for a universal lipid quantitative standard (ULQS) comprising a plurality of isotopically labeled lipid standards that can be used with any analytical mass spectrometry techniques known in the art. The ULQS includes at least one isotopically labeled lipid species from one or more of the following lipid classes: i) phospholipids; ii) lysophospholipids; iii) cholesterol esters; iv) triacylglycerols; v) diacylglycerols; vi) ceramides; and vii) sphingomyelins.
G01N 33/92 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des lipides, p. ex. le cholestérol
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
4.
Therapies for treating and preventing chronic rhinosinusitis
The invention provides compositions and methods for disrupting preformed bacterial biofilm or preventing formation of bacterial biofilm. Also provided in the invention are methods and compositions for treating and preventing chronic rhinosinusitis. Such compositions and methods utilize one or more antibiotic compounds in combination with at least one phospholipid compound described herein.
A61K 31/6615 - Composés ayant plusieurs groupes d'acide du phosphore estérifiés, p. ex. triphosphate d'inositol, acide phytique
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
5.
Oral composition for delivery of drugs and other substances
The present disclosure provides for a composition which may be used for the solubilization of an agent or the oral administration of an agent, the composition comprising, a lysophosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lysophosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lysophosphatidyl compound, a monoglyceride and a free fatty acid.
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
cGMP custom manufacture of active agents, additives, or excipients for others; cGMP custom manufacture of lipids for others; custom manufacturing services for others in the field of active agents, additives, or excipients in pharmaceutical preparations; custom manufacturing services for others in the field of lipids; providing information relating to the custom manufacture of lipids and chemical compounds for scientific and medical research purposes Chemical compounds for scientific or research use; adjuvants for scientific or research use; chemical reagents for the delivery of lipids for scientific or research use; chemical compounds for use as standards for use with analytical techniques, namely, mass spectrometry; compounds for scientific or research use, namely, lipids, synthetic lipids, polymer modified lipids, lipids with modified head groups, lipids with modified acyl chains, bioactive lipids, fluorescent lipids, isotope labeled lipids, oxidized lipids, sphingolipids, lipid extracts from natural sources, lipids conjugated with modified gold particles; compounds for scientific or research use, namely, fatty acids, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, sterol lipids, prenol lipids, lipid preparations suitable for protein crystallization, lipid preparations suitable for protein solubilization, detergents, amphiphilic detergents, and antibodies; diagnostic reagents and analytical reagents for scientific or research use; formulations comprising lipids for scientific or research use; enzymes for scientific or research use; lipids, chemical additives, and excipients for use in the manufacture of pharmaceutical preparations Adjuvants for medical use; immunostimulatory compounds, namely, lipids for medical use; medical diagnostic reagents; test strips for the detection of bacterial infections for medical use; isotopes for medical use Analytical services, namely, performing nutraceutical testing, NMR analysis, mass spectrometry analysis, infrared spectroscopy analysis, chromatography analysis, gas chromatography analysis, particle size analysis, zeta potential analysis, thin layer chromatography analysis, water content analysis, peroxide oxidation and phosphorous content analysis, chemical stability testing, and development of chemical analytical methods; scientific research and medical research services; analytical services, namely, performing nutraceutical testing, NMR analysis, mass spectrometry analysis, infrared spectroscopy analysis, chromatography analysis, gas chromatography analysis, particle size analysis, zeta potential analysis, thin layer chromatography analysis, water content analysis, peroxide oxidation and phosphorous content analysis, chemical stability testing, and development of chemical analytical methods in the field of lipids, nutraceuticals, food products, pharmaceutical products, drug development and commercialization; scientific research and product development and consultation related thereto in the field of pharmaceuticals and chemicals; scientific research services for others; scientific research services for others in the field of lipids, nutraceuticals, food products, pharmaceutical products, drug development and commercialization; lipidomics services, namely, identification and quantification of lipid compounds in a sample, identification of protein-lipid interactions, and identifying the role of lipids in cellular signaling all in the nature of scientific research; cGMP testing services, namely, lipid raw material release testing, developing of testing specifications and standard operating procedures, quality assurance review, product testing, and chemical stability testing all in the field of pharmaceuticals, lipids and chemicals; formulation services, namely, development of standards for liposome and nanoparticle formulations, scaling-up manufacturing processes, and testing and development of standards for synthesis of lipid compounds for use in formulations, in the field of pharmaceuticals, lipids, and chemicals; providing information relating to chemical characterization, analysis methods, and uses of lipids and related compounds for scientific and medical research purpose
The present disclosure provides for a composition which may be used for the solublization of an agent or the oral administration of an agent, the composition comprising, a lyosphosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lyosphosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lyosphosphatidyl compound, a monoglyceride and a free fatty acid.
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
The present disclosure provides for a composition which may be used for the solublization of an agent or the oral administration of an agent, the composition comprising, a lyosphosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lyosphosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lyosphosphatidyl compound, a monoglyceride and a free fatty acid.
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
Essentially pure compounds of the formulas (I) to (XX) are provided. Compositions and methods for enhancing or stimulating an immune response are also provided. The compounds, provided are advantageous in that the compounds are essentially pure and free from contaminants encountered when such compounds are purified from natural sources.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
Essentially pure compounds of the formulas (I) to (XXV) are provided. Compositions and methods for enhancing or stimulating an immune response are also provided. The compounds, provided are advantageous in that the compounds are essentially pure and free from contaminants encountered when such compounds are purified from natural sources.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
Essentially pure compounds of the formulas (I) to (XX) are provided. Compositions and methods for enhancing or stimulating an immune response are also provided. The compounds, provided are advantageous in that the compounds are essentially pure and free from contaminants encountered when such compounds are purified from natural sources.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
BIOCHEMICAL FOR LABORATORY USE, NAMELY PHOSPHOLIPIDS BIOCHEMICAL FOR PHARMACEUTICAL USE, NAMELY PHOSPHOLIPIDS FOR USE AS AN ADDITIVE OR CONCIPIENT IN PHARMACEUTICALS
27.
ORAL COMPOSITION FOR DELIVERY OF DRUGS AND OTHER SUBSTANCES
The present disclosure provides for a composition which may be used for the solublization of an agent or the oral administration of an agent, the composition comprising, a lyosphosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lyosphosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lyosphosphatidyl compound, a monoglyceride and a free fatty acid.
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
28.
COMBINATIONS OF PHOSPHOLIPIDS AND ANTIBACTERIALS FOR TREATING AND PREVENTING CHRONIC RHINOSINUSITIS
The invention provides compositions and methods for disrupting preformed bacterial biofilm or preventing formation of bacterial biofilm. Also provided in the invention are methods and compositions for treating and preventing chronic rhinosinusitis. Such compositions and methods utilize one or more antibiotic compounds in combination with at least one phospholipid compound described herein.
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
Abstract Synthetic disaccharide lipid A analogues of formula (V), (X), (XI), and (XV) are provided. Immunogenic compositions comprising the synthetic disaccharide lipid A analogues of fomiula (V), (X), (XI), and (XV) and methods for enhancing or stimulating an immune response using such compositions are also provided. The synthetic disaccharide lipid A analogues provided are advantageous in that the synthetic disaccharide lipid A analogues are essentially free from contaminants encountered when lipid A compounds are purified from natural sources. Date Recue/Date Received 2020-08-27
The present disclosure provides for a universal lipid quantitative standard (ULQS) comprising a plurality of isotopically labeled lipid standards that can be used with any analytical mass spectrometry techniques known in the art. The ULQS includes at least one isotopically labeled lipid species from one or more of the following lipid classes: i) phospholipids; ii) lysophospholipids; iii) cholesterol esters; iv) triacylglycerols; v) diacylglycerols; vi) ceramides; and vii) sphingomyelins.
G01N 33/92 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des lipides, p. ex. le cholestérol
