Abstract

A compound having the structure (I), (II), (III), or (IV) is provided: (I), (II), (III), (IV) ) where in these structures, (I), (II), (III), and (IV), each R14100100 groups optionally substituted with one or more of alkenyl, alkynyl, hydroxyl, amide, ester, and/or ether groups; R222pp or (A); R3is selected from Formula (V) and Formula (VI): (V, (VI). M+ is selected from an alkali metal ion, an alkaline earth metal ion, or a primary, secondary or tertiary ammonium ion; and m, p, and s are independently selected from integers from 1 to 120. The compound is useful as a liver asialoglycoprotein receptor-targeted therapeutic agent in the form of a lipid nanoparticle, a liposome or a micelle including a drug or oligonucleotide.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• C07H 15/00 - Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals

Goods & Services

Chemical compounds for scientific or research use in vitro studies to test the effects of potential drug compounds on biological targets; adjuvants for scientific or research use, other than for medical or veterinary purposes; chemical reagents for the delivery of lipids for scientific or research use; chemical compounds for use as standards solutions for use with analytical techniques, namely, mass spectrometry; compounds for scientific or research use, namely, lipids, synthetic lipids, polymer modified lipids, lipids with modified head groups, lipids with modified acyl chains, bioactive lipids, fluorescent lipids, isotope labeled lipids, oxidized lipids, sphingolipids, lipid extracts from natural sources, lipids conjugated with modified gold particles; compounds for scientific or research use, namely, fatty acids, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, sterol lipids, prenol lipids, lipid preparations suitable for protein crystallization, lipid preparations suitable for protein solubilization, detergents, amphiphilic detergents, and antibodies; diagnostic reagents and analytical reagents for scientific or research use; formulations comprising lipids for scientific or research use; enzymes for scientific or research use; lipids, chemical additives, and excipients for use in the manufacture of pharmaceutical preparations Chemical compounds for pharmaceutical or medical use, namely, drug delivery agents being excipients for small molecule, protein drug delivery, and adjuvants for vaccines; adjuvants for medical use; immunostimulatory compounds for medical use; medical diagnostic reagents; medical diagnostic test strips for the detection of bacterial infections for medical use; isotopes for medical use Current good manufacturing practice (cGMP) custom manufacture of active agents and additives for others; Current good manufacturing practice (cGMP) custom manufacture of lipids for others; custom manufacturing services for others in the field of active agents, additives, or excipients in pharmaceutical preparations; custom manufacturing services for others in the field of lipids; providing information on chemical manufacturing relating to lipids and related compounds for scientific and medical research purposes

Abstract

The present disclosure provides for a universal lipid quantitative standard (ULQS) comprising a plurality of isotopically labeled lipid standards that can be used with any analytical mass spectrometry techniques known in the art. The ULQS includes at least one isotopically labeled lipid species from one or more of the following lipid classes: i) phospholipids; ii) lysophospholipids; iii) cholesterol esters; iv) triacylglycerols; v) diacylglycerols; vi) ceramides; and vii) sphingomyelins.

IPC Classes  ?

• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present disclosure provides for a universal lipid quantitative standard (ULQS) comprising a plurality of isotopically labeled lipid standards that can be used with any analytical mass spectrometry techniques known in the art. The ULQS includes at least one isotopically labeled lipid species from one or more of the following lipid classes: i) phospholipids; ii) lysophospholipids; iii) cholesterol esters; iv) triacylglycerols; v) diacylglycerols; vi) ceramides; and vii) sphingomyelins.

IPC Classes  ?

• G01N 30/72 - Mass spectrometers
• G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol

Abstract

The invention provides compositions and methods for disrupting preformed bacterial biofilm or preventing formation of bacterial biofilm. Also provided in the invention are methods and compositions for treating and preventing chronic rhinosinusitis. Such compositions and methods utilize one or more antibiotic compounds in combination with at least one phospholipid compound described herein.

IPC Classes  ?

• A61K 31/6615 - Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present disclosure provides for a composition which may be used for the solubilization of an agent or the oral administration of an agent, the composition comprising, a lysophosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lysophosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lysophosphatidyl compound, a monoglyceride and a free fatty acid.

IPC Classes  ?

• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 31/05 - Phenols
• A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
• A61K 31/12 - Ketones
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/00 - Medicinal preparations characterised by special physical form

Goods & Services

(1) Lipid compounds for scientific and research use; chemical adjuvants for the delivery of lipids for scientific and research use; chemical reagents for the delivery of lipids for scientific or research use; standards for use with analytical techniques, namely, spectroscopic solvents for laboratory mass spectrometry analysis; compounds for scientific or research use, namely, lipids, synthetic lipids, polymer modified lipids, lipids with modified head groups, lipids with modified acyl chains, bioactive lipids, fluorescent lipids, isotope labeled lipids, oxidized lipids, sphingolipids, lipid extracts from natural sources, biological compounds conjugated with modified gold particles; compounds for scientific or research use, namely, fatty acids, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, sterol lipids, prenol lipids, lipid preparations suitable for protein crystallization, lipid preparations suitable for protein solubilization, detergents, amphiphilic detergents, and antibodies; diagnostic and analytical reagents for the delivery of lipids for scientific and research use; formulations comprising lipids for scientific or research use; enzymes for scientific and research use, namely, enzyme preparations for use in the chemical industry (2) Lipid compounds for pharmaceutical and medical use; active chemical agents, chemical additives, and chemical excipients for the delivery of lipids in pharmaceutical preparations; chemical adjuvants for the delivery of lipids for pharmaceutical and medical use; immunostimulatory compounds for pharmaceutical or medical use; diagnostic probes for medical laboratory use and clinical diagnostic reagents for medical purposes; test strips for the detection of bacterial infections for medical use; isotopes for medical use (1) Manufacturing services for others in the field of active agents, additives, or excipients in pharmaceutical preparations; manufacturing services for others in the field of lipids (2) Analytical research services for medical purposes; scientific research for medical purposes; analytical services in the field of lipids, nutraceuticals, foodstuffs, pharmaceutical products, drug development and commercialization; research and development and consultation related thereto in the field of pharmaceuticals and chemicals; research services for others in the field of lipids, nutraceuticals, foodstuffs, pharmaceutical products, drug development; research services for others in the field of drug commercialization; lipidomics services; testing of the goods of others to assure compliance with industry standards; formulation services in the field of pharmaceuticals, lipids, and chemicals; engineering services for others in the field of the manufacture of active chemical agents, chemical additives, and chemical excipients for the delivery of lipids; engineering services for others in the field of the manufacture of lipids; providing information relating to lipids and related compounds for scientific and medical research purposes

Goods & Services

cGMP custom manufacture of active agents, additives, or excipients for others; cGMP custom manufacture of lipids for others; custom manufacturing services for others in the field of active agents, additives, or excipients in pharmaceutical preparations; custom manufacturing services for others in the field of lipids; providing information relating to the custom manufacture of lipids and chemical compounds for scientific and medical research purposes Chemical compounds for scientific or research use; adjuvants for scientific or research use; chemical reagents for the delivery of lipids for scientific or research use; chemical compounds for use as standards for use with analytical techniques, namely, mass spectrometry; compounds for scientific or research use, namely, lipids, synthetic lipids, polymer modified lipids, lipids with modified head groups, lipids with modified acyl chains, bioactive lipids, fluorescent lipids, isotope labeled lipids, oxidized lipids, sphingolipids, lipid extracts from natural sources, lipids conjugated with modified gold particles; compounds for scientific or research use, namely, fatty acids, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, sterol lipids, prenol lipids, lipid preparations suitable for protein crystallization, lipid preparations suitable for protein solubilization, detergents, amphiphilic detergents, and antibodies; diagnostic reagents and analytical reagents for scientific or research use; formulations comprising lipids for scientific or research use; enzymes for scientific or research use; lipids, chemical additives, and excipients for use in the manufacture of pharmaceutical preparations Adjuvants for medical use; immunostimulatory compounds, namely, lipids for medical use; medical diagnostic reagents; test strips for the detection of bacterial infections for medical use; isotopes for medical use Analytical services, namely, performing nutraceutical testing, NMR analysis, mass spectrometry analysis, infrared spectroscopy analysis, chromatography analysis, gas chromatography analysis, particle size analysis, zeta potential analysis, thin layer chromatography analysis, water content analysis, peroxide oxidation and phosphorous content analysis, chemical stability testing, and development of chemical analytical methods; scientific research and medical research services; analytical services, namely, performing nutraceutical testing, NMR analysis, mass spectrometry analysis, infrared spectroscopy analysis, chromatography analysis, gas chromatography analysis, particle size analysis, zeta potential analysis, thin layer chromatography analysis, water content analysis, peroxide oxidation and phosphorous content analysis, chemical stability testing, and development of chemical analytical methods in the field of lipids, nutraceuticals, food products, pharmaceutical products, drug development and commercialization; scientific research and product development and consultation related thereto in the field of pharmaceuticals and chemicals; scientific research services for others; scientific research services for others in the field of lipids, nutraceuticals, food products, pharmaceutical products, drug development and commercialization; lipidomics services, namely, identification and quantification of lipid compounds in a sample, identification of protein-lipid interactions, and identifying the role of lipids in cellular signaling all in the nature of scientific research; cGMP testing services, namely, lipid raw material release testing, developing of testing specifications and standard operating procedures, quality assurance review, product testing, and chemical stability testing all in the field of pharmaceuticals, lipids and chemicals; formulation services, namely, development of standards for liposome and nanoparticle formulations, scaling-up manufacturing processes, and testing and development of standards for synthesis of lipid compounds for use in formulations, in the field of pharmaceuticals, lipids, and chemicals; providing information relating to chemical characterization, analysis methods, and uses of lipids and related compounds for scientific and medical research purpose

Goods & Services

CHEMICAL PRODUCTS FOR LABORATORY PURPOSES, NAMELY, REFERENCE STANDARDS FOR USE IN MASS SPECTROMETRY

Goods & Services

CHEMICAL PRODUCTS FOR LABORATORY PURPOSES, NAMELY, REFERENCE STANDARDS FOR USE IN MASS SPECTROMETRY

Goods & Services

CHEMICAL PRODUCTS FOR LABORATORY PURPOSES, NAMELY, REFERENCE STANDARDS FOR USE IN MASS SPECTROMETRY

Goods & Services

CHEMICAL PRODUCTS FOR LABORATORY PURPOSES, namely, REFERENCE STANDARDS FOR USE IN MASS SPECTROMETRY

Abstract

The invention provides compositions and methods for disrupting preformed bacterial biofilm or preventing formation of bacterial biofilm. Also provided in the invention are methods and compositions for treating and preventing chronic rhinosinusitis. Such compositions and methods utilize one or more antibiotic compounds in combination with at least one phospholipid compound described herein.

IPC Classes  ?

• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61P 31/04 - Antibacterial agents

Abstract

The present disclosure provides for a composition which may be used for the solublization of an agent or the oral administration of an agent, the composition comprising, a lyosphosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lyosphosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lyosphosphatidyl compound, a monoglyceride and a free fatty acid.

IPC Classes  ?

• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 31/05 - Phenols
• A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
• A61K 31/12 - Ketones
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form

Goods & Services

Pharmaceuticals, namely, adjuvants for vaccines

Goods & Services

CHEMICAL PRODUCTS FOR LABORATORY PURPOSES, NAMELY, REFERENCE STANDARDS FOR USE IN MASS SPECTROMETRY

Abstract

The present disclosure provides for a composition which may be used for the solublization of an agent or the oral administration of an agent, the composition comprising, a lyosphosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lyosphosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lyosphosphatidyl compound, a monoglyceride and a free fatty acid.

IPC Classes  ?

• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 31/05 - Phenols
• A61K 31/12 - Ketones
• A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Essentially pure compounds of the formulas (I) to (XX) are provided. Compositions and methods for enhancing or stimulating an immune response are also provided. The compounds, provided are advantageous in that the compounds are essentially pure and free from contaminants encountered when such compounds are purified from natural sources.

IPC Classes  ?

• C07H 13/06 - Fatty acids
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present disclosure provides for a composition which may be used for the solublization of an agent or the oral administration of an agent, the composition comprising, a lyosphosphatidyl compound and at least one of a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises a lyosphosphatidyl compound, a monoglyceride and a free fatty acid. In certain embodiments, the composition comprises an agent, a lyosphosphatidyl compound, a monoglyceride and a free fatty acid.

IPC Classes  ?

• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

Goods & Services

Pharmaceuticals, namely, adjuvants for vaccines

Abstract

Essentially pure compounds of the formulas (I) to (XXV) are provided. Compositions and methods for enhancing or stimulating an immune response are also provided. The compounds, provided are advantageous in that the compounds are essentially pure and free from contaminants encountered when such compounds are purified from natural sources.

IPC Classes  ?

• C07H 13/06 - Fatty acids
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Goods & Services

chemical reagents for non-medical purposes, namely, for delivery of lipids

Abstract

AbstractSynthetic disaccharide lipid A analogues of formula (V), (X), (XI), and (XV) are provided. Immunogenic compositions comprising the synthetic disaccharide lipid A analogues of fomiula (V), (X), (XI), and (XV) and methods for enhancing or stimulating an immune response using such compositions are also provided. The synthetic disaccharide lipid A analogues provided are advantageous in that the synthetic disaccharide lipid A analogues are essentially free from contaminants encountered when lipid A compounds are purified from natural sources.Date Recue/Date Received 2020-08-27

IPC Classes  ?

• A61K 8/14 - Liposomes
• A61K 31/7016 - Disaccharides, e.g. lactose, lactulose
• C07H 3/04 - Disaccharides

Abstract

Essentially pure compounds of the formulas (I) to (XX) are provided. Compositions and methods for enhancing or stimulating an immune response are also provided. The compounds, provided are advantageous in that the compounds are essentially pure and free from contaminants encountered when such compounds are purified from natural sources.

IPC Classes  ?

• C07H 13/06 - Fatty acids
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Goods & Services

Chemical preparations for scientific laboratory purposes, namely, chemical standards for use in mass spectrometry

Goods & Services

chemical reagents for non-medical purposes, namely, amphiphilic detergents

Goods & Services

CHEMICAL PREPARATIONS FOR SCIENTIFIC PURPOSES

Goods & Services

phospholipids

Goods & Services

Fluorescent dye used in scientific research as a fluorescent label

Goods & Services

Pharmaceuticals, namely, adjuvants for vaccines including monophosphoryl Lipid A

Goods & Services

BIOCHEMICAL FOR LABORATORY USE, NAMELY PHOSPHOLIPIDS BIOCHEMICAL FOR PHARMACEUTICAL USE, NAMELY PHOSPHOLIPIDS FOR USE AS AN ADDITIVE OR CONCIPIENT IN PHARMACEUTICALS