Methods and systems for the automated collection of plasma from a donor are disclosed. The methods and systems deliver anticoagulant to whole blood and/or to selected and separated components at selected times to provide a sufficient amount of anticoagulant to the selected components to prevent coagulation and/or flocculation. The methods and systems limit the amount of anticoagulant returned to the donor and maximize the amount of collected plasma. Methods and systems for maximize the collection of IgG based on a measured level of total plasma protein are also disclosed.
A method for determining minimum or maximum total blood volume of a donor for a blood processing procedure, using a blood processing device including a controller. The method includes inputting at least one donor characteristic for a donor, performing at least two separate total blood volume calculations to produce at least a first total blood volume and a second total blood volume, and selecting the lowest total blood volume as the minimum total blood volume of the donor or selecting the highest total blood volume for the maximum total blood volume of a donor.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
3.
SYSTEM AND METHOD FOR SEPARATING WHOLE BLOOD INTO BLOOD COMPONENTS
Systems and methods for separating whole blood into blood components includes a blood component separator and a processing circuit. The processing circuit receives whole blood characteristic data and at least one of inventory data and priority data. The processing circuit identifies a blood separator process based on the whole blood characteristic data and the at least one of inventory data and priority data. The blood component separator receives a first container comprising whole blood and automatically operates or is manually operated according to the identified blood separator process to separate at least one blood component from the whole blood for collection into a second or multiple, blood component containers.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
4.
PROCESSING A BIOLOGICAL CELL SUSPENSION FROM A SOURCE
A system and method for processing a biological cell suspension from a source to provide a product in a retentate container comprises a disposable fluid circuit and a reusable hardware unit. The reusable hardware unit comprises a controller which stores processing parameters comprising an estimated volume of biological cell suspension in the source and a concentration of cells in the biological cell suspension. The controller calculates a number of draws of the biological cell suspension and a volume of each draw and calculates a pump speed based on a received processing parameter. The controller controls pumping of the processing solution into the disposable fluid circuit to prime the disposable fluid circuit. The controller directs the withdrawal of the biological cell suspension from the source in batches in accordance with the calculated number of draws and volume of each draw.
A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller determines a total blood volume for a donor based on donor characteristics. The system comprises a touchscreen for receiving a confirming user input and a scanning device configured to scan a bar code associated with a donor. The system and method operate a plurality of draw and return phases.
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
G08B 3/10 - Systèmes de signalisation audibleSystèmes d'appel sonore de personnes utilisant une transmission électriqueSystèmes de signalisation audibleSystèmes d'appel sonore de personnes utilisant une transmission électromagnétique
G08B 5/22 - Systèmes de signalisation optique, p. ex. systèmes d'appel de personnes, indication à distance de l'occupation de sièges utilisant une transmission électriqueSystèmes de signalisation optique, p. ex. systèmes d'appel de personnes, indication à distance de l'occupation de sièges utilisant une transmission électromécanique
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
A distributed computing system for managing blood collection procedures in a blood collection facility includes a system server including a memory and a communication interface, the system server configured to store data identifiers for a plurality of different human operators. A plurality of computerized blood collection instruments are configured to collect blood from donors to generate collected products, each blood collection instrument comprising a communication interface configured to transmit data regarding the blood collection instrument to the system server. The system server stores data identifiers for each blood collection instrument. A computer is coupled to the system server and configured to present a dashboard for improving operational performance at and/or across blood collection facilities. The dashboard displays procedure data, data regarding the plurality of different human operators and data tracking each operator's activities or performance on a display.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G06Q 10/0637 - Gestion ou analyse stratégiques, p. ex. définition d’un objectif ou d’une cible pour une organisationPlanification des actions en fonction des objectifsAnalyse ou évaluation de l’efficacité des objectifs
G06Q 10/087 - Gestion d’inventaires ou de stocks, p. ex. exécution des commandes, approvisionnement ou régularisation par rapport aux commandes
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
7.
SYSTEMS AND METHODS FOR EXPELLING AIR FROM CONTAINERS
Systems and methods for processing whole blood are disclosed. The system includes a reusable separation device and a disposable fluid circuit configured to expel air from multiple product containers.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p. ex. butyromètres
B04B 5/10 - Centrifugeurs combinés avec d'autres appareils, p. ex. avec des séparateurs électrostatiquesEnsembles ou systèmes de plusieurs centrifugeurs
B04B 11/02 - Alimentation ou déchargement en continuSystèmes de commande à cet effet
8.
Fluid Processing System with High Pressure Pneumatic Syringe Pump
A fluid processing system includes a syringe having a barrel and a plunger configured for movement within the barrel, a housing, a syringe support arranged on the housing configured to support the syringe, and a syringe clamp connected to the housing and configured to clamp the syringe to the syringe support. The syringe clamp is connected to the housing and includes a sealing section for sealing against the syringe and a holding section for latching the syringe clamp in a clamped condition. The sealing section is configured to apply a clamping force to a top face of the syringe to form a seal. The holding section includes a clamping surface configured to engage a clamp bearing surface of the syringe support to secure the syringe clamp in the clamped condition.
A fluid processing method and an associated system are provided. The fluid processing method includes a first and second incubation stage which are performed sequentially without any intermediate steps. The fluid processing method creates a second incubation fluid product from a biological fluid.
A fluid processing system includes a fluid processing device and a fluid flow circuit. The device includes a pump configured to convey a priming fluid through the circuit. The pressure in a conduit of the circuit is measured while the pump is operated at a particular rate. When the magnitude of the pressure is less than the magnitude of a predetermined pressure at the end of a time interval, the pump is operated at an increased rate. When the magnitude of the pressure is greater than the magnitude of the predetermined pressure at the end of the time interval, the pump is instead operated at a decreased rate. The magnitude of the pressure in the conduit is again compared to the magnitude of the predetermined pressure after the pump has operated at the increased or decreased rate for the time interval to determine how to next adjust the operational rate.
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 60/113 - Pompes extracorporelles, c.-à-d. que le sang est pompé à l’extérieur du corps du patient incorporées dans des circuits ou des systèmes sanguins extracorporels dans d’autres dispositifs fonctionnels, p. ex. dialyseurs ou cœurs-poumons artificiels
A61M 60/279 - Pompes péristaltiques, p. ex. pompes à rouleau
A61M 60/39 - Leurs finalités médicales étant autres que l’amélioration du débit cardiaque pour transfusion sanguine
A61M 60/554 - Régulation par des données en temps réel de paramètres fonctionnels de la pompe pour le sang, p. ex. par l’intensité du courant d’un moteur de la tension artérielle
11.
METHOD FOR DETERMINING COMPLETION OF PLATELET COLLECTION PROCEDURE
An automated blood processing device includes one or more optical sensors configured to detect intensity of at least a portion of light through a fluid having a concentration of platelets and providing signals indicative of the intensity, and a controller configured to receive the signals from the at least one optical sensor. The controller is configured to determine an instantaneous concentration measurement of platelets within the fluid based on the received signals. In a method for determining completion of a platelet collection procedure, an instantaneous platelet yield is determined based on the instantaneous platelet concentration and a flow rate, and a total platelet yield is determined based on a sum of the instantaneous platelet yields. The method may further include comparing the total platelet yield to a target platelet yield, and ending the procedure if the total platelet yield is greater than the target platelet yield.
A biological fluid processing system and method of operating the system for cell affinity selection. The system having a fluid processor that operates on a fluid circuit having a processing container, a source container filled with a biological fluid, a separation chamber configured to separate the biological fluid from the source container into at least two volumes of material, and a selection column connected to the fluid processor. Modified cells for use in treating a disease, ailment, or medical condition of a patient are also disclosed. The modified cells are produced using a biological fluid processing system. A separation chamber configured to separate the biological fluid from the source container into at least two volumes of material and a processing container for collecting processed cells from the separation chamber are included. A selection column is connected to the fluid circuit for further cell affinity selection processing of the cells.
A blood processing device includes a pump system, a valve system, a continuous-flow centrifuge, and a controller programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping whole blood through a leukoreduction filter and into the centrifuge, separating the blood in the centrifuge into red blood cells and plasma, with an interface between the red blood cells and plasma located at an interface position within the centrifuge, and pumping at least a portion of the red blood cells and at least a portion of the plasma out of the centrifuge.
A method for performing plasmapheresis using a blood separating system including a fluid flow circuit, a blood separator, and a controller. The method includes inputting a hematocrit value for a donor, setting a desired plasma anticoagulant percentage for a plasma product, calculating an initial ratio of anticoagulant to whole blood (ACR), and performing a separation with the separation system. A system is also provided comprising a programmable controller having a screen for receiving input from an operator and configured to provide, based on operator input, an initial ACR and operate the system at the initial ACR.
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
15.
Dynamic Adjustment Of Algorithms For Separation And Collection Of Blood Components
Blood is conveyed from a source into a separator, which separates at least one target blood component from the blood. The target blood component is then conveyed out of the separator, with the procedure continuing until an initial target amount of blood to be processed has been conveyed from the source into the separator and the target blood component separated from the initial target amount of blood to be processed has been conveyed out of the separator as an actual yield of the target blood component. An adjusted target amount of blood to be processed is then determined based at least in part on the difference between a target yield of the target blood component and the actual yield. The initial target amount of blood to be processed is then replaced with the adjusted target amount of blood to be processed when next executing the procedure.
Flexible, blood storage containers are disclosed. The blood storage containers are made of polyvinyl chloride and a mixture of at least two plasticizers in selected ratios.
Containers for the storage of red blood cell compositions are disclosed. The container is a multilayered container wherein the innermost layer includes PVC and more than 30% plasticizer.
B32B 27/08 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique d'une résine synthétique d'une sorte différente
B32B 27/22 - Produits stratifiés composés essentiellement de résine synthétique caractérisée par l'emploi d'additifs particuliers utilisant des plastifiants
B32B 27/30 - Produits stratifiés composés essentiellement de résine synthétique comprenant une résine vinyliqueProduits stratifiés composés essentiellement de résine synthétique comprenant une résine acrylique
B32B 27/32 - Produits stratifiés composés essentiellement de résine synthétique comprenant des polyoléfines
Blood processing systems, devices, and methods including a durable hardware component, a single use fluid flow circuit, and a controller configured to estimate the concentration of platelets in a donor's circulating blood.
An interface monitoring system is provided for detecting the location of an interface between separated fluid components within a channel of a centrifugal separation chamber having a rotational axis. The system includes a light source and a light detector, with the light source being configured to transmit a light along an initial path toward the rotational axis, into the centrifugal separation chamber, and through the channel of the centrifugal separation chamber. The light detector is configured to receive at least a portion of the light as the light exits the centrifugal separation chamber and generate a signal indicative of the location of the interface between separated fluid components within the channel of the centrifugal separation chamber, with the light detector being oriented to receive light traveling in a direction generally perpendicular to the initial path of the light.
An optical detection assembly for monitoring a fluid includes a light source, a light detector array, and a controller. The controller receives signals from the light detector array that are indicative of the intensity of light received by the light detector array after the light has passed through the fluid. The controller generates a scattering profile based on the signals, with the scattering profile including rising and falling edges each having a slope. The controller calculates one or both slopes and determines the platelet mass index (for a platelet-containing fluid) and/or the concentration of a substance in the fluid based on said slope(s). The optical detection assembly may also be used to analyze a reference fluid having a known concentration of the substance, with signals received by the controller when analyzing the reference fluid being a factor when determining the concentration of the substance in the fluid of interest.
Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).
An optical detection assembly for monitoring a biological fluid in a vessel includes two fluid-adjustment structures, which are spaced apart and configured to receive at least a portion of a biological fluid-containing vessel therebetween. A light source (which may be associated with one of the fluid-adjustment structures) is configured to emit light through a thickness of the biological fluid in the vessel, while a light detector (which may be associated with the other one of the fluid-adjustment structures) is configured to receive at least a portion of the light from the light source after it has passed through the biological fluid in the vessel. At least a portion of at least one of the fluid-adjustment structures is configured to move with respect to at least a portion of the other one so as to change the thickness of the biological fluid in the monitored portion of the vessel.
A flow circuit for a blood treatment system includes flow cassettes, a separation chamber fluidically connected to the cassettes, tubings fluidically connecting the cassettes and the separation chamber, the tubings including a plasma tubing including a first column connector, a Luer activated port, and a check valve. The flow circuit has a first configuration for a replacement fluid therapeutic plasma exchange procedure in which the first column connector has first and second mating parts connected to one another, and a second configuration for an adsorption therapeutic plasma exchange procedure in which the flow circuit further comprises an adsorption device having a second column connector and the adsorption device is connected in line with plasma tubing and the first and second mating parts of the first column connector are connected to corresponding first and second parts of the second column connector.
A system for splitting a fluid includes a source support configured to support a source container of a fluid flow circuit and at least one satellite support, with each satellite support configured to support a different satellite container fluidly connected to the source container. A weight scale is associated with each of the supports. The system also includes a clamp system and a controller. The controller is configured to control each weight scale to measure a combined weight of the container and the contents of the container supported by the support associated with the weight scale. The controller is configured to control the clamp system to selectively allow and prevent fluid flow from the source container to each satellite container based at least in part upon the weights measured by each weight scale. Fluid flow continues until the contents of each container have reached a target volume.
G01G 13/26 - Aménagements apportés à un mécanisme de pesée pour commander le remplissage ou la vidange automatique comportant des systèmes de pression par fluide
G01G 13/00 - Appareils de pesée avec remplissage ou vidange automatiques pour peser des quantités données d'un produit
25.
SYSTEMS AND METHODS FOR THE SEPARATION OF CELLS FROM MICROCARRIERS USING A SPINNING MEMBRANE
Methods and systems for processing suspensions of biological cells and microcarriers are disclosed. The biological cells are separated from the microcarriers by introducing the suspension into a spinning membrane separator whereby the biological cells pass through the membrane and the microcarriers do not pass through the membrane.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
A61M 1/16 - Systèmes de dialyseReins artificielsOxygénateurs du sang avec membranes
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 3/04 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus comportant des moyens fournissant des couches minces
A blood processing device includes a controller and a scanner coupled to the controller. The scanner is configured to scan a two-dimensional barcode associated with a component of a disposable processing circuit that is configured to be used in combination with the blood processing device. The scanner transmits a signal to the controller based on information derived from the two-dimensional barcode, with the controller determining information encoded into the two-dimensional barcode based on the signal received from the scanner.
B04B 5/12 - Centrifugeurs dans lesquels l'action centrifuge agissant dans un récipient stationnaire est obtenue par des organes rotatifs autres que des tambours
A fluid processing system includes a separation device, a mononuclear cell product processing device, a pump assembly, and a controller. The controller is programmed to actuate the pump assembly to convey blood from a blood source into the separation device, actuate the separation device to separate a mononuclear cell product from the blood, and actuate the pump assembly to convey at least a portion of the mononuclear cell product through the mononuclear cell product processing device to modify a genome of at least one of the cells of the mononuclear cell product and create a modified mononuclear cell product. The controller is programmed to selectively actuate the pump system to convey the mononuclear cell product through the mononuclear cell product processing device in either a first direction or in an opposite, second direction to modify the genome of at least one of the cells of the mononuclear cell product.
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
C12N 13/00 - Traitement de micro-organismes ou d'enzymes par énergie électrique ou ondulatoire, p. ex. par magnétisme, par des ondes sonores
28.
METHOD FOR DETERMINING RED CELL ADDITIVE SOLUTION VOLUME
Automated blood processing systems and methods including a durable hardware component, a single use fluid flow circuit, and a controller configured to determine and add a custom amount of additive solution. More particularly, systems and methods for adding a custom amount of a red blood cell (RBC) additive solution to obtain a target RBC product with a target hematocrit.
Systems and methods are provided for dynamic calibration and correction of the stroke volume of a pump. During a fluid processing procedure, the change in volume of a fluid in a container associated with a volume measurement system is calculated for a plurality of time periods. The standard deviation of the plurality of changes in volume is calculated, with it being determined that the volume measurement system is operating correctly when the standard deviation is below a target threshold. Upon determining that the volume measurement system is operating correctly, the stroke volume of the pump is calculated and a target change in volume of the fluid in the container is compared to an actual change in volume. When there is a difference between the two changes in volume, a correction factor is calculated, with the operation of the pump being adjusted based at least in part on the correction factor.
G01F 25/00 - Test ou étalonnage des appareils pour la mesure du volume, du débit volumétrique ou du niveau des liquides, ou des appareils pour compter par volume
Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).
A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller determines a total blood volume for a donor based on donor weight, height and gender. The system comprises a touchscreen for receiving a confirming user input and a scanning device configured to scan a bar code associated with a donor. The system and method operate a plurality of draw and return phases.
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
G08B 3/10 - Systèmes de signalisation audibleSystèmes d'appel sonore de personnes utilisant une transmission électriqueSystèmes de signalisation audibleSystèmes d'appel sonore de personnes utilisant une transmission électromagnétique
G08B 5/22 - Systèmes de signalisation optique, p. ex. systèmes d'appel de personnes, indication à distance de l'occupation de sièges utilisant une transmission électriqueSystèmes de signalisation optique, p. ex. systèmes d'appel de personnes, indication à distance de l'occupation de sièges utilisant une transmission électromécanique
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
32.
ADMINISTERING A DRUG TO A PATIENT WITH AN INFUSION PUMP
Changing a data set on an infusion pump may use a processing circuit which receives infusion pump history data from a plurality of infusion pumps, the infusion pump history data comprising a reprogram event and an override event. A plurality of the reprogram events and the override events are stored in a memory. Display data is generated for presentation on a display indicating, for a drug, a number of infusion events that occurred for the drug, a number of override events that occurred for the drug, a percentage of override events that occurred for the drug, a number of reprogram events that occurred for the drug, and a percentage of reprogram events that occurred for the drug. After generating the display data, a change is received to a data set, the data set is downloaded to the infusion pump, and the infusion pump administers a drug to the patient.
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
G16H 15/00 - TIC spécialement adaptées aux rapports médicaux, p. ex. leur création ou leur transmission
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
33.
SYSTEMS AND METHODS FOR OPTIMIZATION OF PLASMA COLLECTION VOLUMES
A system and a method for collecting plasma has a separator, a donor line, an anticoagulant line, a touchscreen, and a controller. The controller controls operation of the system and receives donor parameters electronically from a donor management system. The controller uses a target volume for plasma product and/or raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for plasma product and/or raw plasma based on the total donor blood volume. The controller controls the system to operate at least three draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and the red blood cells and to return the red blood cells to the donor
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61M 1/38 - Extraction de constituants du sang du donneur et retour de la fraction restante vers le corps
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
34.
BEDSIDE CELL PROCESSING SYSTEM HAVING A REINFUSION SYSTEM
A bedside cell processing system including an apheresis system configured to collect from a patient a blood component comprising target cells, a cell processing system configured to receive the target cells from the apheresis system and to process the target cells, and a reinfusion system configured to receive the processed target cells and to return the processed cells to the patient. A method of operating a bedside cell processing system for a patient also is provided, including operating the apheresis system to collect from the patient via a collection flow path a blood component comprising target cells, operating a cell processing system to receive the target cells via a collected target cells flow path and to process the target cells, operating the reinfusion system to receive the processed target cells via a processed target cells flow path and to return the processed target cells to the patient.
A plasma storage container includes a bottle, with a connector (which may be unitarily formed) connected to a neck of the bottle. A gasket may be positioned between the neck and the connector to provide a seal along an interface therebetween. Inlet and outlet tubes are connected (e.g., via bonding) to the connector, with the connector defining an inlet flow path from the inlet tube to the interior of the bottle and an outlet flow path from the interior of the bottle to the outlet tube. A bottom end of the inlet flow path may extend farther into the interior of the bottle than the bottom end of the outlet flow path.
A61J 1/05 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques pour recueillir, stocker ou administrer du sang, du plasma ou des liquides à usage médical
A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques DétailsAccessoires à cet effet
36.
Device Screen Interaction Using a Scanner and Bidirectional Data Transfer
A biological fluid processing system and a method of executing a biological fluid processing procedure is disclosed. The biological fluid processing system includes a processing device, a scanner, and a data management system. The processing device includes a display screen and a controller which operates the processing device to implement a biological fluid processing procedure having a plurality of steps. The controller displays an image on the display screen. The scanner interacts with the device screen to retrieve data from the image and transmit the data to the data management system. The scanner and/or the data management system transmit a signal to the controller based on the data. The controller initiates at least one step of the biological fluid processing procedure upon receiving the signal.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
A biological fluid processing device includes pump and valve systems, a centrifuge and a controller. The controller is configured to operate the pump and valve systems to convey buffy coat into the centrifuge, operate the centrifuge at a first rotation rate to separate the buffy coat into platelets and red blood cells, operate the pump and valve systems to convey a first portion of the separated platelets from the centrifuge for collection, and operate the pump and valve systems to convey the separated red blood cells from the centrifuge for collection. The controller is further configured to operate the centrifuge at one or more second rotation rates lower than the first rotation rate, operate the pump and valve systems to convey the collected red blood cells into the centrifuge, and operate the pump and valve systems to convey a second portion of the platelets from the centrifuge for collection.
Methods and systems for performing an apheresis procedure with a reduced risk of citrate reaction occurrences are described. The volume of body water in the apheresis subject is used to predict the likelihood of a citrate reaction during infusion of a blood component to the subject and allows for establishing and maintaining an optimal flow rate of the infused blood component.
Systems are provided for collecting, separating, concentrating and modifying blood components from whole blood for reinfusion. The system includes a blood processing device and a fluid flow circuit.
Systems are provided for collecting, sorting, and concentrating blood components from whole blood for reinfusion. The system may further include cell modification. The system includes a blood processing device and a fluid flow circuit.
A method of processing blood includes receiving from a touch screen user input data for a protocol for a wash procedure. The user input data includes a numeric value. The method includes storing the protocol in a memory, receiving an identifier from a user, determining if the identifier permits the user to modify the protocol and receiving a modification of the protocol from the user. The method includes providing a plurality of authorizations, a second authorization being a default and an administrator authorization permitting the user to change a setting. The method includes comparing a password to a password stored in memory and, if there is a match, determining that the password is associated with an administrator. If a command to change the setting is received, the command is applied to change the setting. The blood is processed employing a wash procedure using the modified protocol and the changed setting.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
A61M 1/26 - Systèmes de dialyseReins artificielsOxygénateurs du sang avec membranes en mouvement
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
G05B 13/02 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
42.
Apparatus, systems and methods for storing, treating and/or processing blood and blood components
Apparatus, systems and methods are disclosed relating to certain aspects of blood processing, collecting or storing, including method and system for automated authentication, processing device with scanner, blood container with two dimensional barcode, blood collection containers, blood container label and related tracking method, integrated container system, and processing device with sterile connection device.
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 39/12 - Raccords ou accouplements pour tubes pour raccorder un tube flexible à un dispositif de fixation rigide
A61M 39/18 - Procédés ou appareils pour réaliser les connexions sous conditions stériles
B01D 21/26 - Séparation du sédiment avec emploi de la force centrifuge
B04B 5/12 - Centrifugeurs dans lesquels l'action centrifuge agissant dans un récipient stationnaire est obtenue par des organes rotatifs autres que des tambours
A packaging tray for use in a blood processing system including a blood processing device having device components arranged on a component surface and a removable fluid flow circuit having circuit components configured to interact with corresponding device components, wherein the packaging tray configured to be selectively arranged on and removable from the component surface. The packaging tray includes a first surface and a second surface opposite to the first surface and spaced apart by a thickness, component sections arranged at positions corresponding to positions of respective device components, the component sections respectively formed, at least partially, as openings extending through the thickness, and a plurality of recessed pathways formed on the first surface, the recessed pathways extending between the component sections. A blood processing device may include the packaging tray, and a blood processing system may include a blood processing device and the packaging tray.
A fluid distribution system for distributing fluid between a plurality of containers. The system includes a fluid circuit, stopcocks, and fluid containers, wherein the stopcocks are configured to control flow of fluid through the fluid circuit and the distribution of fluid between the plurality of containers.
Blood is conveyed from a source into a separator, which separates at least one target blood component from the blood. The target blood component is then conveyed out of the separator, with the procedure continuing until an initial target amount of blood to be processed has been conveyed from the source into the separator and the target blood component separated from the initial target amount of blood to be processed has been conveyed out of the separator as an actual yield of the target blood component. An adjusted target amount of blood to be processed is then determined based at least in part on the difference between a target yield of the target blood component and the actual yield. The initial target amount of blood to be processed is then replaced with the adjusted target amount of blood to be processed when next executing the procedure.
Systems and methods are provided for collecting a platelet product having a target concentration. First and second target concentrations are first selected. Blood is then separated into red blood cells and platelet-rich plasma, with the platelet-rich plasma then being separated into platelet-poor plasma and platelet concentrate. At least a portion of the platelet concentrate is collected in a container as a platelet product having an actual platelet concentration, attempting to collect platelet concentrate having the first target concentration. After separation of the blood has been completed, at least a portion of the platelet-poor plasma and/or an additive solution is pumped into the container to decrease the concentration of the platelet product from the actual platelet concentration to the second target concentration.
A system and method for collecting plasma comprises a control circuit configured to control operation of the system, the control circuit configured to receive one or more donor parameters. The control circuit estimates a physiological fluid amount of the donor based at least in part on the one or more donor parameters and calculates a target amount of plasma product comprising raw plasma and anticoagulant by multiplying a prestored constant by the estimated physiological fluid amount. The control circuit controls the system to operate draw and return phases to process whole blood into plasma product until a measured amount of plasma product in the collection container meets the target amount of plasma product.
A configurable automated blood component manufacturing system includes a durable hardware component and a single use fluid flow circuit. The hardware component includes a pump station, a centrifuge, and a controller including a touchscreen. The hardware component further includes hangers for suspending containers, a weight scale associated with each hanger, a plurality of tubing clamps, and a cassette nesting module including a plurality of valves and pressure sensors. The fluid flow circuit includes a separation chamber received in the centrifuge, a fluid flow control cassette mounted in the cassette nesting module, and a plurality of containers in fluid communication with the fluid flow cassette. The controller is pre-programmed to automatically operate the system to perform one or more standard blood processing procedures selected by an operator by input to the touchscreen, and is configured to be further programmed by the operator to perform additional blood processing procedures.
Systems and methods are provided to recover residual biological fluid from a soft sided fluid filter having an inlet and an outlet and which is used by a biological fluid processing system, including a reusable hardware unit comprising a fluid filter compression assembly. The fluid filter compression assembly further includes a housing having an outer wall that defines a housing space that receives the fluid filter, at least one bladder positioned within the housing space, at least one conduit, at least one pump, wherein the at least one conduit is in fluid communication with the at least one bladder and the at least one pump, and at least one clamp configured to selectively stop flow through the fluid filter inlet.
A centrifuge includes a yoke driven at a rotational speed with respect to a stationary frame of the centrifuge by a drive shaft extending from a motor. A timing belt engages a stationary sun gear and a planet gear, with rotation of the yoke rotating the timing belt and the planet gear. A shaft is associated with the planet gear, with rotation of the planet gear causing the shaft and an associated first sheave to rotate within and with respect to the yoke. Another timing belt engages the first sheave, with rotation of the first sheave causing the second timing belt and a second sheave to rotate with respect to the yoke. A receptacle rotates with the second sheave to cause a fluid separation chamber to rotate with respect to the stationary frame at a speed that is double the rotational speed at which the drive shaft is driven.
A distributed computing system for managing blood collection procedures in a blood collection facility includes a system server including a memory and a communication interface, the system server configured to store data identifiers for a plurality of different human operators. A plurality of computerized blood collection instruments are configured to collect blood from donors to generate collected products, each blood collection instrument comprising a communication interface configured to transmit data regarding the blood collection instrument to the system server. The system server stores data identifiers for each blood collection instrument. A computer is coupled to the system server and configured to present a dashboard for improving operational performance at and/or across blood collection facilities. The dashboard displays procedure data, data regarding the plurality of different human operators and data tracking each operator's activities or performance on a display.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G06Q 10/0637 - Gestion ou analyse stratégiques, p. ex. définition d’un objectif ou d’une cible pour une organisationPlanification des actions en fonction des objectifsAnalyse ou évaluation de l’efficacité des objectifs
G06Q 10/087 - Gestion d’inventaires ou de stocks, p. ex. exécution des commandes, approvisionnement ou régularisation par rapport aux commandes
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
52.
SYSTEM AND METHOD FOR PREVENTING PATIENT REACTIONS DURING BLOOD DRAW
A method and system for drawing and collecting blood and/or blood components is disclosed. The method and system include a patient temperature monitoring device for monitoring a patient's temperature throughout a collection procedure, which includes an infrared camera. The infrared camera may be calibrated regularly to ensure accurate measurements.
A blood processing device includes a pump system, a valve system, a centrifuge, and a controller configured and/or programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping blood into the centrifuge, separating the blood in the centrifuge into red blood cells and plasma, and collecting portions of the separated red blood cells and plasma. Subsequently, a portion of the collected red blood cells is pumped back into the centrifuge to collect an additional amount of the separated plasma. A buffy coat or white blood cell layer may be formed between the separated red blood cells and plasma in the centrifuge. If so, a portion of the collected plasma may be pumped back into the centrifuge to harvest the buffy coat or white blood cell layer.
A system and method for splitting a fluid into fluid products with a component count within a designated component count range and volume within a designated volume range. The method includes measuring an initial component concentration of a source container, weighing a source container to determine the volume of fluid, calculating the final component count and final volume for each of the source and at least one satellite container, calculating the amount of component additive solution to add the source container and flowing the amount of component additive solution from a component additive solution container into the source container, and splitting the fluid so that each divided fluid amount has a final component count within a designated component count range and a final volume within a designated volume range.
A system for altering blood flowrate during donation comprising a height adjustable blood collection assembly including: a base, a tower extending upward from the base, an actuator and a carrier; the actuator is coupled to the carrier and the tower, and the actuator vertically adjusts the carrier relative to the base; a receptacle being connected to the carrier and configured to receive a blood collection container; and a controller that interacts with at least the actuator.
A blood processing device includes a pump system, a valve system, a centrifuge, and a controller configured and/or programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping blood into the centrifuge at an inflow rate, separating the blood in the centrifuge into red blood cells and plasma, with an interface between the red blood cells and plasma located at an interface position within the centrifuge, and pumping at least a portion of the red blood cells and at least a portion of the plasma out of the centrifuge. The controller is configured and/or programmed to employ an inflow rate and/or an interface position that is based at least in part on the temperature of the blood.
A method of processing blood or a blood product using an automated system includes displaying on a display a listing of a plurality of blood processing procedures that may be performed using the system and receiving operator input selecting one of the blood processing procedures that is to be performed. The method includes displaying on the display a list of parameters that are associated with the selected blood processing procedure and receiving operator input selecting a plurality of the parameters that are to populate the display during performance of the procedure. The method includes receiving operator input indicating a format in which the selected parameters are to be presented on the display. The method includes displaying values for the selected plurality of parameters in the indicated format during performance of the specified procedure.
A61M 1/38 - Extraction de constituants du sang du donneur et retour de la fraction restante vers le corps
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
58.
Centrifugal Separation And Collection Of Red Blood Cells And Plasma
Systems and methods are provided for separating blood into two or more components for collection of red blood cells, plasma, or both red blood cells and plasma. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit, with the blood being separated into its constituents by the centrifugal separator. Separated plasma may be collected following separation by the centrifugal separator or may first be conveyed from the centrifugal separator into the spinning membrane separator drive unit to separate cellular blood components from the plasma prior to collection of the filtered plasma. The cellular blood components filtered from the plasma may be retained in the circuit as a waste product or may be flushed out of the circuit to a recipient.
A method for determining a total volume of anticoagulant required for performing a plasmapheresis procedure prior to connecting the donor to the fluid flow circuit, by determining: a total blood volume for a donor, volume of plasma to be collected, a volume of anticoagulant that will be collected together with the plasma and estimating a separation efficiency for the blood separator. Then calculating volume of anticoagulant to be returned to the donor based on the separation efficiency, total volume of anticoagulant to be used and suggesting and attaching either a single container or multiple containers of anticoagulant based on said calculations. The system comprises a touch screen for receiving input and providing said calculation of a total volume of anticoagulant needed for the procedure, and recommendation the number of containers of anticoagulant needed.
A head-mounted display device for interface with a medical device includes a frame configured to be mounted on a user's head, a display, a wireless transceiver configured to communicate with a network, and a processing circuit. The medical device is configured to perform an invasive procedure on the person. The processing circuit receives a notification message from the medical device. The processing circuit records medical device information in response to receiving the notification message from the medical device.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A method and system for donating blood and/or blood components is disclosed. The method and system include at least one adjustment mechanism to alter at least one feature of a blood draw in order to minimize and/or prevent donor reactions.
Blood donation frequency is optimized by incentive structures uniquely tailored to individual blood donors. An incentive structure may include incentive offers of different values, with each value being based at least in part on the predicted quality of a blood product produced from blood donated by the donor on a particular date. The structure may alternatively or additionally include one or more incentive offers that are each valued based at least in part on the predicted likelihood of the donor having an adverse reaction to a blood donation occurring on a particular date. The structure may alternatively or additionally include one or more incentive offers that are each valued based at least in part on the predicted likelihood of an attempted blood donation by the target donor being deferred on a particular date.
Medical containers and disposable fluid circuits (kits) including such containers are disclosed. The containers and kit components are made of a plastic composition including polyvinyl chloride and one or more plasticizers such as a citrate ester and an epoxidized vegetable oil are disclosed. Containers made from such compositions are useful in the storage red blood cells. Red blood cell products wherein the red blood cells exhibit a reduced level of hemolysis are also disclosed.
The pressure of fluid being conveyed through a fluid flow path during a biological fluid procedure is detected during the procedure. The fluid is conveyed through the fluid flow path 1) at a first pre-determined rate if pressure is zero to a first pressure threshold; 2) at the first pre-determined rate if pressure is greater than the first pressure threshold but less than or equal to a second pressure threshold and if an immediately preceding rate is equal to the first pre-determined rate; 3) at a second pre-determined rate if pressure is greater than the first pressure threshold but less than or equal to the second pressure threshold and if an immediately preceding rate is equal to the second pre-determined rate; and 4) at the second pre-determined rate if pressure value is greater than the second pressure threshold but less than or equal to a third pressure threshold.
An optical plasma grading system includes a broadband light source configured to emit light having wavelengths in a visible spectrum, an optical spectrometer configured to receive a reflected portion of the emitted light and analyze at least a portion of the received, reflected light to determine a main wavelength of the portion of the received reflected light, and a controller operably connected to the optical spectrometer, the controller configured to determine a plasma grade of the plasma based at least upon the main wavelength of the plasma.
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
A method and system for separating a suspension of biological fluids is disclosed. The method and system include measuring and adjusting the flow rate of fluid into and out of a separator in order to achieve a target outlet concentration.
Systems and methods for the optimization of blood collection and therapies using an automated blood cell separator are disclosed. The systems and methods calculate or determine recommended settings based on, among other things, one or more of historical collection data, set defaults, contamination limits, blood, and blood component characteristics.
A plasmapheresis system and a method for operating a plasmapheresis system are provided by which a volume of plasma product (i.e., anticoagulated plasma) so that that the targeted volume of pure plasma in the plasma product is determined based on donor-specific characteristics. In particular, the targeted amount of pure plasma to be collected is based on the weight, or the weight and the height, of the donor. The targeted volume of pure plasma to be collected, TVP, may be a multiple of the donors weight. Alternatively, TVP may be a multiple of the donor's total blood volume, TBV, with the TBV of the donor being determined based on the donor's weight and height. A target volume for the plasma product to be collected, TVPP, is established, and separation of whole blood into a plasma component and a second component continues until the volume of plasma product in a collection container equals TVPP.
Systems and methods are provided for determining and controlling the location of an interface between separated blood components within a centrifuge. An optical monitoring assembly is used to determine the position of the interface, with the current position being compared to a target position. An error signal, which is indicative of the distance between the two positions, is input into a proportional-integral-derivative control algorithm to generate a control signal. The control signal is used to modify the rate at which a separated blood component is removed from the centrifuge so as to move the interface toward the target position. Blood characteristics, blood source characteristics, and/or the rate at which blood is pumped into the centrifuge are monitored for any changes, with a change in one or more of these factors being used to modify the control algorithm.
A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller determines a total blood volume for a donor based on donor weight, height and gender. The system comprises a touchscreen for receiving a confirming user input and a scanning device configured to scan a bar code associated with a donor. The system and method operate a plurality of draw and return phases.
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
G08B 3/10 - Systèmes de signalisation audibleSystèmes d'appel sonore de personnes utilisant une transmission électriqueSystèmes de signalisation audibleSystèmes d'appel sonore de personnes utilisant une transmission électromagnétique
G08B 5/22 - Systèmes de signalisation optique, p. ex. systèmes d'appel de personnes, indication à distance de l'occupation de sièges utilisant une transmission électriqueSystèmes de signalisation optique, p. ex. systèmes d'appel de personnes, indication à distance de l'occupation de sièges utilisant une transmission électromécanique
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
71.
SYSTEMS FOR THE EXTENDED STORAGE OF RED BLOOD CELLS
Systems for the prolonged storage of red blood cells (RBCs) are disclosed. The system includes a container made of a polymeric composition including polyvinyl chloride and a mixture of two or more hemolysis suppressing agents, and a storage medium that includes a fat emulsion entrained therein.
A blood processing system includes a durable hardware component and a single-use fluid flow circuit. The hardware component includes a controller configured to execute a procedure in which red blood cells are separated from whole blood and collected. An additive solution may be initially provided in a red blood cell collection container of the fluid flow circuit, with the controller actuating a pump system of the hardware component to convey the additive solution from the red blood cell collection container into an additive solution container of the fluid flow circuit. After red blood cells have been separated from blood and conveyed into the red blood cell collection container (along with at least a portion of the additive solution from the additive solution container), the red blood cells and additive solution in the red blood cell collection container may be conveyed into a whole blood container for collection and storage.
An unmanned helicopter system and method for delivering a blood product to a target includes a body, a plurality of spinning rotors, each rotor comprising at least one propeller, and a cord coupled to a container configured to contain a blood product. A drop mechanism lowers the cord and blood product and resists gravitational acceleration of the container during at least a portion of a descent of the container. A control circuit navigates the helicopter to the target location and, while airborne, receives a command to deliver the blood product. The control circuit, in response to receiving the command, controls the drop mechanism to lower the cord and container containing the blood product to the target location.
Systems and methods for managing inventories of blood components are disclosed. Such systems and methods are configured to improve the predictability, efficiency, and/or automation of blood component supply chains. Tools are provided for tracking blood component inventories, using blood component demand, and coordinating donations to meet current and anticipated demand. Some embodiments of the systems and methods identify when blood component units at a health care facility are beginning to run low or are approaching expiration, before the need for additional units becomes critical. Some embodiments of the systems and methods coordinate new donations and modify existing scheduled donations to meet real-time and forecasted demand for blood components.
G06Q 10/087 - Gestion d’inventaires ou de stocks, p. ex. exécution des commandes, approvisionnement ou régularisation par rapport aux commandes
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
75.
Interface Detection And Control Using A Photodetector Array
Systems and methods are provided for determining and controlling the location of an interface between separated fluid components within a channel of a centrifugal separation chamber being rotated about a rotational axis. Light from a light source is received by a collimator, which directs collimated light through the channel in a direction substantially parallel to the rotational axis. At least a portion of the collimated light exiting the channel is received by a light detector configured as a photodetector array. A signal emitted by the light detector is received by a controller, which determines the location of an interface between separated fluid components within the channel based at least in part on the signal. When the controller determines that the interface is not at a target location within the channel, the controller controls a centrifugal separator and/or a pump system to move the interface to the target location.
B04B 13/00 - Systèmes de commande spécialement conçus pour les centrifugeursCommande à programme des centrifugeurs
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p. ex. butyromètres
76.
Systems And Methods For Implementing Different Versions Of A Blood Separation Procedure
A blood separation device has a controller configured to execute a first and a second version of a blood separation procedure. Information regarding a blood source is analyzed to determine whether to implement the first version of the procedure or the second version. This may include an analysis of the age, weight, and/or sex of the blood source, along with whether the blood source has previously been the subject of a blood separation procedure. The second version may allow for a greater percentage of the blood or red blood cells of the blood source to be outside of the body of the blood source (in a fluid flow circuit mounted to the device) at any time during the procedure. The second version may also or alternatively allow for a higher blood cell separation efficiency than the first version, along with separating the blood in a larger blood separation chamber.
A centrifuge assembly including a rotating component and an active electronic device associated with the rotating component. The active electronic device being powered by a contactless power source.
B04B 5/10 - Centrifugeurs combinés avec d'autres appareils, p. ex. avec des séparateurs électrostatiquesEnsembles ou systèmes de plusieurs centrifugeurs
A device, system, and method for sterilizing a fluid pathway connection are disclosed. The device, system, and method utilize a hand-held sterilization device. The device may create temporary sterile flow paths.
A61L 2/10 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations des ultraviolets
Systems, devices and methods for establishing a sterile fluid flow path between two or more fluid processing sets are disclosed. The systems, devices and methods include two or more connectors to which tubes of two or more fluid processing sets are attached. The connectors are brought together in an air-tight, non-permanent engagement with one another and treated with sterilizing light.
Biological fluid processing cassettes with integrated filter structures are disclosed. A cassette body is formed of a generally rigid material, defining a plurality of internal fluid flow paths. The cassette body may be secured to a cassette cap to define a cavity, with a filter sealed within the cavity. Each of the cassette body and the cassette cap defines a port opening into the cavity, which allows fluid to flow from one of the internal fluid flow paths, into the cavity and through the filter, and then out of the cavity via the port of the cassette cap. Alternatively, the cassette body may define an external slot which receives at least a portion of a filter. Such a filter includes two ports, with one of the ports in fluid communication with a cassette port of the cassette body to allow fluid flow between the cassette body and the filter.
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
B01D 29/03 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants avec des éléments filtrants plats autoportants
A method (and a system for implementing such method) for creating a plurality of fluid products each having a minimum content of a fluid component includes providing a plurality of intermediate fluid volumes each having a known content of a fluid component. The intermediate fluid volumes are grouped by fluid component content, followed by a determination of whether two of the intermediate fluid volumes may be pooled to achieve the minimum content for a final fluid product. The method proceeds with creating combinations of three and then more intermediate fluid volumes achieving the minimum content for a final fluid product, followed by creating combinations of intermediate fluid volumes exceeding the minimum content. Each intermediate fluid volume is assigned to only one of the combinations, with the intermediate fluid volumes being assigned to the combinations so as to maximize the number of combinations and, thus, the number of final fluid products.
A system and method for collecting whole blood from blood donors includes first and second whole blood collection devices disposed at different blood donation centers. A remote server computer is in communication with the blood collection devices. The whole blood collection devices transfer donation procedure information to the remote server. The remote server computer facilitates retrieval of the donation procedure information at a handheld computing device. The donation procedure information includes data based on product volume collected and data indicating performance of operators of the whole blood collection devices. The handheld computing device displays a number of whole blood units collected. Blood collection can be improved using the donation procedure information.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G06Q 10/087 - Gestion d’inventaires ou de stocks, p. ex. exécution des commandes, approvisionnement ou régularisation par rapport aux commandes
G06Q 10/1093 - Ordonnancement basé sur un agenda pour des personnes ou des groupes
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G06T 11/20 - Traçage à partir d'éléments de base, p. ex. de lignes ou de cercles
83.
Cell processing system and method with preliminary process evaluation
A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.
A61M 1/26 - Systèmes de dialyseReins artificielsOxygénateurs du sang avec membranes en mouvement
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
84.
System and Methods Incorporating Replacement Fluid Maximization
A processing system includes a processor including a separator, a set configured to cooperate with the separator to separate whole blood into plasma and other components, the set including an inlet line attachable to a patient to receive whole blood and an return line attachable to a patient to return processed fluid, and a source of replacement fluid connected to the disposable set, the processor configured to combine the other components with replacement fluid to define the processed fluid. The processor includes a controller and an input device coupled to the controller, the controller configured to receive an input via the input device, the input representing a volume of replacement fluid, and to control the processor to separate whole blood passing through the set and to combine the other components with the replacement fluid according to the input until the source of replacement fluid is empty.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
85.
Continuous-Flow Centrifuge Chambers Having A Non-Uniform Radius High-G Wall
Fluid separation chambers are provided with a central hub, with generally annular low-G and high-G walls extending about the hub to define therebetween a separation channel. A plurality of radial walls extend from the hub to the channel to define an inlet passage, two outlet passages, and a terminal wall separating an upstream end of the separation channel from a downstream end of the channel. The radius of the high-G wall is greater at the downstream end of the separation channel than at the upstream end, which may include the radius gradually increasing along a tapered section of the high-G wall. The tapered section may extend from the upstream end of the separation channel to the downstream end of the channel or along a smaller length of the channel. The radius of the low-G wall may similarly increase from the upstream end of the separation channel to the downstream end.
A fluid separation system and method includes a durable hardware component including a pump station with plurality of pumps, a centrifuge mounting station and drive unit, a plurality of valves and clamps, and a controller. The system includes a single use fluid flow circuit having a separation chamber configured to be received by the centrifuge and the fluid flow circuit is engageable with the durable hardware component to control fluid flow within the fluid flow circuit. The fluid flow circuit having an air access component configured to selectively receive air and to provide the air into a conduit to induce plug flow between the separated fluid component and another separated fluid component, wherein the controller is configured to operate the system to perform one or more blood processing procedures to convey a fluid into the separation chamber and to remove a separated fluid component from the separation chamber.
An optical detection assembly for monitoring a fluid includes a light source, a light detector array, and a controller. The light source emits light into a fluid, while the light detector array includes a plurality of light detectors and receives light exiting the fluid. The controller determines the concentration of one or more substances in the fluid based on signals received from the light detector array. The assembly may include a second light detector array, with one array receiving transmitted light exiting the fluid, with the other receiving scattered light exiting the fluid. The assembly may include a vessel attachment receiving a portion of a vessel or a vessel connector connecting two vessels. The controller may be configured to determine the concentration of one or more substances in a fluid within a vessel received by a vessel attachment or in a fluid within a conduit defined by a vessel connector.
A fluid separation device includes a centrifugal separator configured to receive a centrifugal separation chamber of a disposable fluid flow circuit, a pump system configured to convey a fluid into the centrifugal separation chamber and to remove a separated fluid component from the centrifugal separation chamber via an outlet, a color-based interface monitoring system configured to determine an interface position between separated fluid components continuously flowing through the centrifugal separation chamber based on dominant wavelength measurements of layers of separated fluid components during a centrifugal separation procedure, and a controller configured to measure the dominant wavelengths of the layers, calculate a duration as a color time for each measured dominant wavelength, set target color times, calculate error signals and calculate control signals to adjust the pump system to control the flow rate and interface position.
B04B 11/02 - Alimentation ou déchargement en continuSystèmes de commande à cet effet
G01N 13/00 - Recherche des effets de surface ou de couche limite, p. ex. pouvoir mouillantRecherche des effets de diffusionAnalyse des matériaux en déterminant les effets superficiels, limites ou de diffusion
B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p. ex. butyromètres
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
89.
DEVICES AND METHODS FOR PROCESSING WHOLE BLOOD USING FLOW RATE STOPPAGE PHASE
A device and method for separating whole blood includes flowing whole blood to a centrifuge, separating whole blood into blood components within the centrifuge, and flowing separated blood components out of the centrifuge. The device and method include a flow rate stoppage phase executed one or more times during the method. The flow rate stoppage phase includes (i) stopping the flow of whole blood to the centrifuge and stopping the flow of separated blood components out of the centrifuge; (ii) spinning the centrifuge at a selected rate; and (iii) after a selected time ending the flow rate stoppage phase and resuming the flow of whole blood to the centrifuge and the flow of separated blood components out of the centrifuge.
Systems and methods are provided for improving efficiency and quality of plasma being removed from a blood separation chamber. The system includes a separation chamber in which plasma is separated from cellular blood components, a pump for moving the plasma and an outlet line for removing the separated plasma from the blood separation chamber. An optical sensor assembly is configured to monitor the blood separation chamber and measure an interface position between the separated component and the plasma, and to generate an output indicative of the measured interface position. A controller is programmed to utilize a lipid concentration input of the blood and to set an original lipemia offset, a lipemia threshold and lipemia final setpoint from a predetermined database, and to use a proportional-integral-derivative control loop to assess the actual interface position plus the lipemia threshold to adjust and achieve a final lipemia setpoint for use during separation procedures.
A computer-implemented method comprises providing a fluid circuit comprising fluid pathways configured to mount and associate with a durable processing device comprising a pressure sensor in communication with a controller and a fluid pathway. A container is connected to the pressure sensor and may receive a volume of fluid. A change in pressure values between a first and second time is measured from when the volume of fluid is not in communication with the pressure sensor to when the volume of fluid is in communication with the pressure sensor, the volume of fluid within the container or a presence or absence of a fluid connection to the fluid pathway based on the change in pressure values is determined, and a response action is executed if the volume of fluid within the container is not within an authorized volume range for the time period, or if a fluid connection is unauthorized.
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
92.
Systems and methods for optimization of plasma collection volumes
A method of collecting plasma includes receiving donor parameters at a controller of a plasma collection device electronically from a donor management system. The method includes storing a target volume for raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for raw plasma based on the total donor blood volume. The method includes setting the target volume for raw plasma and controlling the plasma collection device to operate draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and a second blood component comprising red blood cells and to return the second blood component to the donor. The controller operates the draw and return phases until a volume of raw plasma in the collection container equals the target volume of raw plasma.
A61M 1/34 - Filtration du sang à travers une membrane pour en éliminer une matière, c.-à-d. hémofiltration, diafiltration
A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation
A61M 1/38 - Extraction de constituants du sang du donneur et retour de la fraction restante vers le corps
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
93.
Systems And Methods For Setting A Continuous-Flow Centrifuge Rotation Rate
A fluid processing device includes a controller, a centrifuge, and a pump system. The controller controls the pump system to convey a fluid into a centrifuge chamber received by the centrifuge at first and second rates, with the controller also controlling the centrifuge to rotate the chamber at a first rotation rate when the fluid is being conveyed into the chamber at the first rate and controlling the centrifuge to rotate the chamber at a second rotation rate when the fluid is being conveyed into the chamber at the second rate. The first and second rotation rates are different, with each being based at least in part on a concentration of a fluid component within the fluid, the rate at which the pump system is conveying the fluid into the centrifuge chamber, and a target concentration of the fluid component in one of the first and second constituents.
Described is a method for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit.
Methods and systems for transfusing reduced-volume blood components are disclosed. Previously collected blood components are introduced into a fluid circuit associated with an apparatus that further separates the component into a reduced volume component and supernatant. The reduced-volume blood component is transfused to the patient in need of the component without the risk of circulatory overload.
Systems and methods are provided for separating blood components from whole blood. A blood processing device, as part of a blood processing system, has a controller configured to operate the blood processing device based on a plurality of collection protocols. The blood processing device is wirelessly connected to a remote computing device configured to maintain a plurality of collection protocols. At least one additional computing device is configured to update one or more of the plurality of collection protocols on said remote computing device by communicating changes to a protocol maintained on the remote computing device which updates the plurality of collection protocols at the controller of the blood processing device.
A blood separation system is provided with a data entry device, a blood separator, a pump system, and a controller. The controller compares data regarding a blood source that is received by the data entry device and/or calculated values derived from the data to a target range, a maximum value, and/or a minimum value. The controller requests reentry or confirmation of at least a portion of the data when the data or calculated value is outside of the target range, less than the minimum value, and/or greater than the maximum value. The controller instead proceeds with a blood separation procedure when the data or calculated value is not outside of the target range, less than the minimum value, and/or greater than the maximum value or after determining that there have been no data entry errors.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
A61M 1/02 - Appareils pour transfusion sanguine d'un corps à un autre
98.
Medium and methods for the storage of red blood cells
An aqueous storage solution for the storage of red blood cells, comprising an aqueous solution and at least one lipid, wherein the at least one lipid is effective in suppressing hemolysis in red blood cells and wherein the at least one lipid is emulsified within the aqueous solution.
A magnetic selector includes a housing configured to receive a container and having a floor upon which the container is disposed. The selector also includes a magnet carrier disposed on an opposite side of the floor from the container. The magnet carrier has at least one magnet disposed thereon and being moveable relative to the floor between a first state wherein the magnet carrier is adjacent the floor and a second state wherein the magnet carrier is spaced from the floor. The selector may include a door. The magnetic selector is usable in a fluid processing system that includes a fluid processor connectable to a source container filled with a biological fluid. A container is disposed in the magnetic selector and connected to the processor along a fluid pathway. The processor is configured to separate the biological fluid from the source container into at least two streams of material.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
E05C 17/56 - Dispositifs pour tenir les battants dans une position d'ouvertureDispositifs pour limiter l'ouverture des battants ou pour tenir les battants dans une position d'ouverture par une pièce mobile disposée entre le battant et le dormantDispositifs de freinage, butées ou tampons combinés avec ces dispositifs par attraction magnétique ou électro-magnétique
100.
Blood Pack Donation System for Biomarker Collection During Whole Blood Donation
A blood pack donation system configured for use with a lab-on-a-chip device for biomarker collection during whole blood donation including a blood collection container, a biomarker collection container, a first flow path connected to an opening in the blood collection container and to a first outlet opening of a lab-on-a-chip device, a second flow path connected to an opening in the biomarker collection container and to a second outlet opening of the lab-on-a-chip device, and a third flow path connected to a needle and to an inlet opening of the lab-on-a-chip device. The system may be used in a single pass collection procedure. A second version includes a fourth flow path connected to the first flow path and to the third flow path, with a plurality of flow control components that selectively control flow to provide a single pass collection procedure or a multiple pass collection procedure.
