Systems are provided for collecting, sorting, and concentrating blood components from whole blood for reinfusion. The system may further include cell modification. The system includes a blood processing device and a fluid flow circuit.
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A61M 60/39 - Medical purposes thereof other than the enhancement of the cardiac output for blood transfusion
A61M 60/427 - Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being hydraulic or pneumatic
A61M 60/508 - Electronic control means, e.g. for feedback regulation
A fluid distribution system for distributing fluid between a plurality of containers. The system includes a fluid circuit, stopcocks, and fluid containers, wherein the stopcocks are configured to control flow of fluid through the fluid circuit and the distribution of fluid between the plurality of containers.
F04B 13/02 - Pumps specially modified to deliver fixed or variable measured quantities of two or more fluids at the same time
F04B 9/123 - Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being elastic, e.g. steam or air having only one pumping chamber
F04B 49/22 - Control of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for in, or of interest apart from, groups by means of valves
3.
Adjustment Of The Measurement Of The Cell Concentration Of A Fluid
A biological fluid processing device includes pump and valve systems, a controller, and an optical detection assembly. During a biological fluid processing procedure, the controller controls the operation of the pump and valve systems to separate a cell-containing fluid from the blood of a blood source and controls the optical detection assembly to emit light through the cell-containing fluid. The controller receives signals from the optical detection assembly that are indicative of the intensity of light that has passed through the cell-containing fluid. The controller receives or calculates an adjustment factor that is derived from historical data reflecting a cell collection procedure previously executed for the same blood source in which the same type of cell was collected. The controller determines an adjusted cell concentration of the cell-containing fluid based at least in part on the signals from the light detector and the adjustment factor.
Systems and methods are provided for controlling the location of an interface between separated blood components within a centrifuge. An optical monitoring assembly determines the current position of the interface, with the current position and a plurality of input parameters being transmitted from a controller to a neural network. The neural network employs artificial intelligence techniques to analyze the current interface position and at least one of the input parameters to determine a modification to be made to at least one procedural parameter so as to move the interface from its current position to a target position. The neural network transmits a signal that is indicative of the modification to the controller, which implements the modification so as to move the interface toward the target position, with the modification being to an inflow rate, a centrifuge rotation rate, an outflow rate, and/or the location of the target interface position.
Devices and methods for optically measuring fluid flow are disclosed. The devices and methods include a multi-component, multichannel cuvette associated with a fluid circuit. The multi-component, multichannel cuvette includes a molded body and first and second transparent walls.
A sterile connection device includes first and second carriages, each defining a portion of a first dock and a portion of a second dock. A first blade is associated with the first dock, while a second blade is associated with the second dock. When a pair of tubes is received in only the first dock, the tubes are cut using the first blade, then joined, and then a single replacement blade is moved into association with the second dock, which moves the second blade into association with the first dock and removes the first blade from association with the first dock. When a pair of tubes is received in each dock, the tubes are cut using the first and second blades, then joined, and then two replacement blades are moved into association with the docks, which moves the first and second blades out of association with the docks.
A blood processing system includes a reuseable processing device and a single use fluid flow circuit. The reuseable hardware component includes a pump system, a valve system, and a centrifuge. The reuseable hardware component further includes a controller and holders for collection containers. The disposable fluid flow circuit includes a plurality of collection containers, a processing chamber received by the centrifuge and a plurality of conduits fluidly connecting the components of the fluid flow circuit. The controller is configured to command the pump system and the valve system to cooperate to convey whole blood from a blood source to the processing chamber and execute at least one blood processing procedure. The holders are configured so that the collection containers remain upright during the duration of the at least one blood processing procedure.
A platelet collection device and method of using machine learning to predict a platelet yield of a source of biological fluid is described. The method includes retrieving a corpus of platelet collection data comprising donor parameters and measured platelet yields for a plurality of platelet collections. The method includes training a machine learning algorithm using the corpus of platelet collection data, the machine learning algorithm being trained to predict the platelet yield based on input donor parameters. The method includes using the machine learning algorithm to receive a set of input donor parameters for the person and predict the platelet yield. The method includes processing the biological fluid to collect a platelet product.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61M 1/38 - Removing constituents from donor blood and returning remainder to body
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A blood donation collection system includes a blood collection device configured to perform an apheresis function to collect blood components. A database stores records for a plurality of blood donors. A processing circuit is configured to display data from a plurality of the records on a display screen, run a collection optimization algorithm based on blood center inventory level and past donation history data to make a recommendation for a blood collection procedure, and display the recommendation. The processing circuit is configured to receive a user selection of the recommendation for the blood collection procedure and send an instruction to collect a blood component to the blood collection device. The processing circuit is configured to monitor the collection by the blood collection device.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
10.
PLASMA COLLECTION BASED ON DONOR EXTRACELLULAR FLUID
A system and method for collecting plasma comprises a control circuit configured to control operation of the system, the control circuit configured to receive one or more donor parameters. The control circuit estimates a physiological fluid amount of the donor based at least in part on the one or more donor parameters and calculates a target amount of plasma product comprising raw plasma and anticoagulant by multiplying a prestored constant by the estimated physiological fluid amount. The control circuit controls the system to operate draw and return phases to process whole blood into plasma product until a measured amount of plasma product in the collection container meets the target amount of plasma product.
Systems and methods are provided for monitoring and dynamically adjusting the operation of a pneumatic pump. The pump is controlled to alternately apply an initial negative pressure and an initial positive pressure to a flexible diaphragm of a pump chamber to draw fluid into the chamber and then convey the fluid from the chamber. The initial pressures are selected to be the minimum negative pressure at which the chamber is expected to completely fill during application of negative pressure to the diaphragm for an inflow duration and the minimum positive pressure at which the chamber is expected to completely empty during application of positive pressure to the diaphragm for an outflow duration. If a complete fill and/or a complete empty is not achieved, then the appropriate initial pressure is increased in order to arrive at the minimum pressures at which a complete fill and empty are actually achieved.
A blood separation device includes a pump system, a separator, and a controller. The controller is programmed to execute a blood separation procedure including a red blood cell collection stage in which blood is conveyed into the separator, red blood cells are separated from the blood in the separator, and the separated red blood cells are conveyed from the separator into a collection container. The red blood cell collection stage is ended when a target volume of blood has been separated in the separator. The controller then determines a percentage of the red blood cells from the target volume of blood that have been collected in the collection container based on the volume of red blood cells and the hematocrit of the fluid in the collection container, a volumetric flow rate of pure red blood cells in the blood conveyed into the separator, and the procedure time.
Receptacles for use in fluid lines of aliquot fluid circuit in a fluid distribution system and method of treating air bubbles in fluid lines of an aliquot fluid circuit in a fluid distribution system are disclosed therein. The receptacle is configured to trap and remove gas (e.g., air bubbles) that flows into the receptacle from the fluid lines. The receptacle is in fluid communication with a product (aliquot) container.
Systems and methods are provided for separating blood into two or more components for collection of red blood cells, plasma, or both red blood cells and plasma. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit, with the blood being separated into its constituents by the centrifugal separator. Separated plasma may be collected following separation by the centrifugal separator or may first be conveyed from the centrifugal separator into the spinning membrane separator drive unit to separate cellular blood components from the plasma prior to collection of the filtered plasma. The cellular blood components filtered from the plasma may be retained in the circuit as a waste product or may be flushed out of the circuit to a recipient.
A cell selection chamber includes an inlet and an outlet, with a reservoir positioned therebetween and configured to allow for fluid flow from the inlet to the outlet. The reservoir contains a plurality of microbubbles, which are each at least partially coated with streptavidin. An upstream membrane is positioned between the inlet and the reservoir, while a downstream membrane is positioned between the outlet and the reservoir. The membranes include a plurality of pores each having a diameter that is less than a diameter of the microbubbles. In use, a heterogeneous population of cells is mixed with a biotinylated antibody additive and then conveyed into the cell selection chamber so as to cause target cells of the heterogeneous population of cells to become bound to the microbubbles and to cause other cells of the heterogeneous population of cells to flow out of the cell selection chamber as unbound cells.
Modified cells for use in the treatment of a disease, ailment, or medical condition of a patient are produced from target cells using a fluid flow circuit which may be part of a blood processing system. The fluid flow circuit includes a separation module, at least one pump, at least one fluid reservoir for holding fluids during a blood processing procedure, a valve system, at least one fluid source container, at least one cell modification module, a blood source access device, and a plurality of conduits fluidly connecting the components of the fluid flow circuit. The blood processing system includes the fluid flow circuit and a controller configured and/or programmed to control the operation of the fluid flow circuit.
Devices and methods for optically measuring fluid flow are disclosed. The devices and methods include a multi-component cuvette associated with a fluid circuit. The multi-component cuvette includes a molded body and first and second transparent walls.
Systems and method for separating, collecting, treating target cells and infusing the treated target cells to a patient are disclosed. The closed system includes a pre-defined fluid pathway providing flow communication between a whole blood source and said patient.
Modified cells for use in the treatment of a disease, ailment, or medical condition of a patient are produced using a bedside cell modification system. The system includes an apheresis system, a cell modification subsystem, and a reinfusion system. The apheresis system is configured to collect from the patient a blood component comprising target cells. The cell modification subsystem is configured to receive the target cells from the apheresis system and to modify the target cells. The reinfusion system is configured to receive the modified target cells from the cell modification subsystem and to return the modified cells to the patient so as to treat the disease, ailment, or medical condition of the patient.
Modified cells for use in the treatment of a disease, ailment, or medical condition of a patient are produced from target cells using a fluid flow circuit which may be part of a blood processing system. The fluid flow circuit includes a microfluidic sorter module, a cell concentrator module, at least one pump, at least one fluid reservoir for holding fluids during a blood processing procedure, a valve system, at least one fluid source container, a blood source access device, and a plurality of conduits fluidly connecting the components of the fluid flow circuit. The blood processing system includes the fluid flow circuit and a reusable hardware device comprising a controller configured and/or programmed to initiate and at least partially control the processing of biological cells through the fluid flow circuit.
Systems and methods for ensuring the proper placement of color-coded tubing on a medical device are disclosed. The system includes one or more sensors and a computer memory containing a database of acceptable colors associated with said one or more sensors. The system is configured to compare the measured color of said color-coded tubing to colors of a color database, wherein the sensor is associated with a color from said database.
An optical detection assembly for monitoring a fluid in a vessel includes a light source, a light detector array and a controller programmed to receive the light transmission intensity signals from the light detector array over a predetermined time interval, measure light transmission intensity over the predetermined time interval based on the light transmission intensity signals, calculate a frequency and/or an amplitude of the light transmission intensity signals over the predetermined time interval, compare the calculated frequency to a threshold frequency and/or the calculated amplitude to a threshold amplitude, and determine whether cellular material is present in the fluid based on the comparison of the calculated frequency to the threshold frequency and/or the calculated amplitude to the threshold amplitude.
A blood donation collection method includes transmitting a request for data from a donor record to a remote server computer over a network interface circuit and receiving the data from the donor record from the remote server computer. The data comprises an indication of a blood component collected at a previous donor collection. The method includes providing display data indicating an amount of the blood component the donor may donate at a current donor collection based on the indication of the blood component collected at a previous donor collection. The method includes receiving a user request to schedule a current donor collection, and transmitting instructions for the requested current donor collection to a blood component collection device, wherein the blood component collection device collects a blood component from a donor using the instructions.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
24.
Determination Of The Cell Concentration Of A Fluid For Facilities Using Differently Configured Cell Counters
A method of determining a cell concentration of a subject fluid includes first determining an unadjusted cell concentration of each of a plurality of fluids based on an intensity of light emitted through the fluid and a correlation curve derived using a first cell counter. A measured cell concentration obtained for each fluid from a second cell counter is then plotted against the unadjusted cell concentration to create a curve represented by an equation that is selected to be used as an adjustment equation. Light is then emitted through the subject fluid, with at least a portion of the light exiting the subject fluid being received. An unadjusted cell concentration of the subject fluid is determined based on the correlation curve and the intensity of the received light. The adjustment equation is then applied to the unadjusted concentration to determine an adjusted cell concentration of the subject fluid.
A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61M 1/26 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes which are moving
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
26.
Cell Processing System And Method With Preliminary Process Evaluation
A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61M 1/26 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes which are moving
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
27.
SYSTEM AND METHOD FOR DETERMINING RED BLOOD CELL AND BUFFY COAT PLATELET QUALITY BASED ON PLASMA CHARACTERIZATION
A blood processing and/or manufacturing system includes a processing device and a fluid flow circuit selectively arranged on the processing device. The processing device is configured to interact with the fluid flow circuit to perform one or more blood separation procedures in which plasma is separated from whole blood. The system further includes an optical grading system arranged relative to a vessel of the fluid flow circuit containing the separated plasma, wherein the optical grading system is configured to determine a main wavelength of the plasma in the vessel and determine a red blood cell grade and/or a buffy coat platelet grade based on the main wavelength of the plasma.
G01N 15/05 - Investigating sedimentation of particle suspensions in blood
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
28.
SYSTEMS AND METHODS FOR DETERMINATION OF CAUSE OF LEUKOREDUCTION FLOW RESTRICTION
Systems, devices, and methods for processing whole blood are disclosed. The system includes a reusable separation device, a disposable fluid circuit, and a controller configured to detect a flow restriction within a leukoreduction filter and to determine the cause of the flow restriction.
A blood processing system includes a durable hardware component and a single-use fluid flow circuit. The hardware component includes a controller configured to execute a procedure in which red blood cells are separated from whole blood and collected. An additive solution may be initially provided in a red blood cell collection container of the fluid flow circuit, with the controller actuating a pump system of the hardware component to convey the additive solution from the red blood cell collection container into an additive solution container of the fluid flow circuit. After red blood cells have been separated from blood and conveyed into the red blood cell collection container (along with at least a portion of the additive solution from the additive solution container), the red blood cells and additive solution in the red blood cell collection container may be conveyed into a whole blood container for collection and storage.
Systems and methods for performing therapeutic plasma exchange are provided. The systems and methods utilize a plasmapheresis device that includes a controller that is configured and/or programmed to monitor the amount plasma collected and initiate delivery of a therapeutic agent.
A head-mounted display device for interface with a medical device configured to perform an invasive procedure on a patient includes a frame configured to be mounted on a person's head, a display, a camera, a wireless transceiver configured to communicate with a network, and a processing circuit. The processing circuit is configured to acquire an image of a component of the medical device with the camera, to process the image to identify a characteristic of the component, to determine whether the component is authorized for use, and to transmit a message to the medical device based on whether the component is authorized for use.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
Fluid separation chambers are provided with a central hub, with generally annular low- and high-G walls extending about the hub to define therebetween a separation channel. A terminal wall separates an upstream end of the separation channel from a downstream end. A plurality of radial walls extend from the hub to the separation channel to define an inlet passage and two outlet passages. The outlet passages may open into the separation channel at a bottom end of the channel. A ramp extends generally diagonally across the separation channel, from the high-G wall to the low-G wall. The ramp may be positioned at the downstream end of the separation channel or a portion of the ramp may extend to the bottom end of the channel.
An optical sensor assembly of a centrifuge of a biological fluid separation system includes a light source configured to emit light having an intensity toward a separation chamber received within the centrifuge, with at least a portion of the light exiting the separation chamber as transmitted light. A light detector receives at least a portion of the transmitted light as received light and transmits a signal based on the received light. A controller receives the signal from the light detector, then determines the location of an interface between two of the separated components within the separation chamber based at least in part of the signal. The controller is programmed to determine whether to control the light source to dynamically adjust the intensity of the light during a biological fluid separation procedure and/or to control the light detector to dynamically adjust an amplification of the signal during the procedure.
An unmanned helicopter system and method for delivering a blood product to a target includes a body, a plurality of spinning rotors, each rotor comprising at least one propeller, and a cord coupled to a container configured to contain a blood product. A drop mechanism lowers the cord and blood product and resists gravitational acceleration of the container during at least a portion of a descent of the container. A control circuit navigates the helicopter to the target location and, while airborne, receives a command to deliver the blood product. The control circuit, in response to receiving the command, controls the drop mechanism to lower the cord and container containing the blood product to the target location.
B64U 10/16 - Flying platforms with five or more distinct rotor axes, e.g. octocopters
B64U 101/55 - UAVs specially adapted for particular uses or applications for life-saving or rescue operationsUAVs specially adapted for particular uses or applications for medical use
B64U 101/67 - UAVs specially adapted for particular uses or applications for transporting passengersUAVs specially adapted for particular uses or applications for transporting goods other than weapons the UAVs comprising tethers for lowering the goods
Methods and systems for the automated collection of plasma from a donor are disclosed. The methods and systems deliver anticoagulant to whole blood and/or to selected and separated components at selected times to provide a sufficient amount of anticoagulant to the selected components to prevent coagulation and/or flocculation. The methods and systems limit the amount of anticoagulant returned to the donor and maximize the amount of collected plasma. Methods and systems for maximize the collection of IgG based on a measured level of total plasma protein are also disclosed.
A method for determining minimum or maximum total blood volume of a donor for a blood processing procedure, using a blood processing device including a controller. The method includes inputting at least one donor characteristic for a donor, performing at least two separate total blood volume calculations to produce at least a first total blood volume and a second total blood volume, and selecting the lowest total blood volume as the minimum total blood volume of the donor or selecting the highest total blood volume for the maximum total blood volume of a donor.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
37.
SYSTEM AND METHOD FOR SEPARATING WHOLE BLOOD INTO BLOOD COMPONENTS
Systems and methods for separating whole blood into blood components includes a blood component separator and a processing circuit. The processing circuit receives whole blood characteristic data and at least one of inventory data and priority data. The processing circuit identifies a blood separator process based on the whole blood characteristic data and the at least one of inventory data and priority data. The blood component separator receives a first container comprising whole blood and automatically operates or is manually operated according to the identified blood separator process to separate at least one blood component from the whole blood for collection into a second or multiple, blood component containers.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
38.
PROCESSING A BIOLOGICAL CELL SUSPENSION FROM A SOURCE
A system and method for processing a biological cell suspension from a source to provide a product in a retentate container comprises a disposable fluid circuit and a reusable hardware unit. The reusable hardware unit comprises a controller which stores processing parameters comprising an estimated volume of biological cell suspension in the source and a concentration of cells in the biological cell suspension. The controller calculates a number of draws of the biological cell suspension and a volume of each draw and calculates a pump speed based on a received processing parameter. The controller controls pumping of the processing solution into the disposable fluid circuit to prime the disposable fluid circuit. The controller directs the withdrawal of the biological cell suspension from the source in batches in accordance with the calculated number of draws and volume of each draw.
A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller determines a total blood volume for a donor based on donor characteristics. The system comprises a touchscreen for receiving a confirming user input and a scanning device configured to scan a bar code associated with a donor. The system and method operate a plurality of draw and return phases.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
G08B 3/10 - Audible signalling systemsAudible personal calling systems using electric transmissionAudible signalling systemsAudible personal calling systems using electromagnetic transmission
G08B 5/22 - Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electric transmissionVisible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electromagnetic transmission
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
A distributed computing system for managing blood collection procedures in a blood collection facility includes a system server including a memory and a communication interface, the system server configured to store data identifiers for a plurality of different human operators. A plurality of computerized blood collection instruments are configured to collect blood from donors to generate collected products, each blood collection instrument comprising a communication interface configured to transmit data regarding the blood collection instrument to the system server. The system server stores data identifiers for each blood collection instrument. A computer is coupled to the system server and configured to present a dashboard for improving operational performance at and/or across blood collection facilities. The dashboard displays procedure data, data regarding the plurality of different human operators and data tracking each operator's activities or performance on a display.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G06Q 10/0637 - Strategic management or analysis, e.g. setting a goal or target of an organisationPlanning actions based on goalsAnalysis or evaluation of effectiveness of goals
G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
41.
SYSTEMS AND METHODS FOR EXPELLING AIR FROM CONTAINERS
Systems and methods for processing whole blood are disclosed. The system includes a reusable separation device and a disposable fluid circuit configured to expel air from multiple product containers.
A fluid processing system includes a syringe having a barrel and a plunger configured for movement within the barrel, a housing, a syringe support arranged on the housing configured to support the syringe, and a syringe clamp connected to the housing and configured to clamp the syringe to the syringe support. The syringe clamp is connected to the housing and includes a sealing section for sealing against the syringe and a holding section for latching the syringe clamp in a clamped condition. The sealing section is configured to apply a clamping force to a top face of the syringe to form a seal. The holding section includes a clamping surface configured to engage a clamp bearing surface of the syringe support to secure the syringe clamp in the clamped condition.
A fluid processing method and an associated system are provided. The fluid processing method includes a first and second incubation stage which are performed sequentially without any intermediate steps. The fluid processing method creates a second incubation fluid product from a biological fluid.
A fluid processing system includes a fluid processing device and a fluid flow circuit. The device includes a pump configured to convey a priming fluid through the circuit. The pressure in a conduit of the circuit is measured while the pump is operated at a particular rate. When the magnitude of the pressure is less than the magnitude of a predetermined pressure at the end of a time interval, the pump is operated at an increased rate. When the magnitude of the pressure is greater than the magnitude of the predetermined pressure at the end of the time interval, the pump is instead operated at a decreased rate. The magnitude of the pressure in the conduit is again compared to the magnitude of the predetermined pressure after the pump has operated at the increased or decreased rate for the time interval to determine how to next adjust the operational rate.
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A61M 60/279 - Peristaltic pumps, e.g. roller pumps
A61M 60/39 - Medical purposes thereof other than the enhancement of the cardiac output for blood transfusion
A61M 60/554 - Regulation using real-time blood pump operational parameter data, e.g. motor current of blood pressure
45.
METHOD FOR DETERMINING COMPLETION OF PLATELET COLLECTION PROCEDURE
An automated blood processing device includes one or more optical sensors configured to detect intensity of at least a portion of light through a fluid having a concentration of platelets and providing signals indicative of the intensity, and a controller configured to receive the signals from the at least one optical sensor. The controller is configured to determine an instantaneous concentration measurement of platelets within the fluid based on the received signals. In a method for determining completion of a platelet collection procedure, an instantaneous platelet yield is determined based on the instantaneous platelet concentration and a flow rate, and a total platelet yield is determined based on a sum of the instantaneous platelet yields. The method may further include comparing the total platelet yield to a target platelet yield, and ending the procedure if the total platelet yield is greater than the target platelet yield.
A biological fluid processing system and method of operating the system for cell affinity selection. The system having a fluid processor that operates on a fluid circuit having a processing container, a source container filled with a biological fluid, a separation chamber configured to separate the biological fluid from the source container into at least two volumes of material, and a selection column connected to the fluid processor. Modified cells for use in treating a disease, ailment, or medical condition of a patient are also disclosed. The modified cells are produced using a biological fluid processing system. A separation chamber configured to separate the biological fluid from the source container into at least two volumes of material and a processing container for collecting processed cells from the separation chamber are included. A selection column is connected to the fluid circuit for further cell affinity selection processing of the cells.
A blood processing device includes a pump system, a valve system, a continuous-flow centrifuge, and a controller programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping whole blood through a leukoreduction filter and into the centrifuge, separating the blood in the centrifuge into red blood cells and plasma, with an interface between the red blood cells and plasma located at an interface position within the centrifuge, and pumping at least a portion of the red blood cells and at least a portion of the plasma out of the centrifuge.
A method for performing plasmapheresis using a blood separating system including a fluid flow circuit, a blood separator, and a controller. The method includes inputting a hematocrit value for a donor, setting a desired plasma anticoagulant percentage for a plasma product, calculating an initial ratio of anticoagulant to whole blood (ACR), and performing a separation with the separation system. A system is also provided comprising a programmable controller having a screen for receiving input from an operator and configured to provide, based on operator input, an initial ACR and operate the system at the initial ACR.
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
49.
Dynamic adjustment of algorithms for separation and collection of blood components
Blood is conveyed from a source into a separator, which separates at least one target blood component from the blood. The target blood component is then conveyed out of the separator, with the procedure continuing until an initial target amount of blood to be processed has been conveyed from the source into the separator and the target blood component separated from the initial target amount of blood to be processed has been conveyed out of the separator as an actual yield of the target blood component. An adjusted target amount of blood to be processed is then determined based at least in part on the difference between a target yield of the target blood component and the actual yield. The initial target amount of blood to be processed is then replaced with the adjusted target amount of blood to be processed when next executing the procedure.
Flexible, blood storage containers are disclosed. The blood storage containers are made of polyvinyl chloride and a mixture of at least two plasticizers in selected ratios.
Containers for the storage of red blood cell compositions are disclosed. The container is a multilayered container wherein the innermost layer includes PVC and more than 30% plasticizer.
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
B32B 27/22 - Layered products essentially comprising synthetic resin characterised by the use of special additives using plasticisers
Blood processing systems, devices, and methods including a durable hardware component, a single use fluid flow circuit, and a controller configured to estimate the concentration of platelets in a donor's circulating blood.
An interface monitoring system is provided for detecting the location of an interface between separated fluid components within a channel of a centrifugal separation chamber having a rotational axis. The system includes a light source and a light detector, with the light source being configured to transmit a light along an initial path toward the rotational axis, into the centrifugal separation chamber, and through the channel of the centrifugal separation chamber. The light detector is configured to receive at least a portion of the light as the light exits the centrifugal separation chamber and generate a signal indicative of the location of the interface between separated fluid components within the channel of the centrifugal separation chamber, with the light detector being oriented to receive light traveling in a direction generally perpendicular to the initial path of the light.
An optical detection assembly for monitoring a fluid includes a light source, a light detector array, and a controller. The controller receives signals from the light detector array that are indicative of the intensity of light received by the light detector array after the light has passed through the fluid. The controller generates a scattering profile based on the signals, with the scattering profile including rising and falling edges each having a slope. The controller calculates one or both slopes and determines the platelet mass index (for a platelet-containing fluid) and/or the concentration of a substance in the fluid based on said slope(s). The optical detection assembly may also be used to analyze a reference fluid having a known concentration of the substance, with signals received by the controller when analyzing the reference fluid being a factor when determining the concentration of the substance in the fluid of interest.
Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).
An optical detection assembly for monitoring a biological fluid in a vessel includes two fluid-adjustment structures, which are spaced apart and configured to receive at least a portion of a biological fluid-containing vessel therebetween. A light source (which may be associated with one of the fluid-adjustment structures) is configured to emit light through a thickness of the biological fluid in the vessel, while a light detector (which may be associated with the other one of the fluid-adjustment structures) is configured to receive at least a portion of the light from the light source after it has passed through the biological fluid in the vessel. At least a portion of at least one of the fluid-adjustment structures is configured to move with respect to at least a portion of the other one so as to change the thickness of the biological fluid in the monitored portion of the vessel.
A flow circuit for a blood treatment system includes flow cassettes, a separation chamber fluidically connected to the cassettes, tubings fluidically connecting the cassettes and the separation chamber, the tubings including a plasma tubing including a first column connector, a Luer activated port, and a check valve. The flow circuit has a first configuration for a replacement fluid therapeutic plasma exchange procedure in which the first column connector has first and second mating parts connected to one another, and a second configuration for an adsorption therapeutic plasma exchange procedure in which the flow circuit further comprises an adsorption device having a second column connector and the adsorption device is connected in line with plasma tubing and the first and second mating parts of the first column connector are connected to corresponding first and second parts of the second column connector.
A system for splitting a fluid includes a source support configured to support a source container of a fluid flow circuit and at least one satellite support, with each satellite support configured to support a different satellite container fluidly connected to the source container. A weight scale is associated with each of the supports. The system also includes a clamp system and a controller. The controller is configured to control each weight scale to measure a combined weight of the container and the contents of the container supported by the support associated with the weight scale. The controller is configured to control the clamp system to selectively allow and prevent fluid flow from the source container to each satellite container based at least in part upon the weights measured by each weight scale. Fluid flow continues until the contents of each container have reached a target volume.
Methods and systems for processing suspensions of biological cells and microcarriers are disclosed. The biological cells are separated from the microcarriers by introducing the suspension into a spinning membrane separator whereby the biological cells pass through the membrane and the microcarriers do not pass through the membrane.
A blood processing device includes a controller and a scanner coupled to the controller. The scanner is configured to scan a two-dimensional barcode associated with a component of a disposable processing circuit that is configured to be used in combination with the blood processing device. The scanner transmits a signal to the controller based on information derived from the two-dimensional barcode, with the controller determining information encoded into the two-dimensional barcode based on the signal received from the scanner.
A fluid processing system includes a separation device, a mononuclear cell product processing device, a pump assembly, and a controller. The controller is programmed to actuate the pump assembly to convey blood from a blood source into the separation device, actuate the separation device to separate a mononuclear cell product from the blood, and actuate the pump assembly to convey at least a portion of the mononuclear cell product through the mononuclear cell product processing device to modify a genome of at least one of the cells of the mononuclear cell product and create a modified mononuclear cell product. The controller is programmed to selectively actuate the pump system to convey the mononuclear cell product through the mononuclear cell product processing device in either a first direction or in an opposite, second direction to modify the genome of at least one of the cells of the mononuclear cell product.
Automated blood processing systems and methods including a durable hardware component, a single use fluid flow circuit, and a controller configured to determine and add a custom amount of additive solution. More particularly, systems and methods for adding a custom amount of a red blood cell (RBC) additive solution to obtain a target RBC product with a target hematocrit.
Systems and methods are provided for dynamic calibration and correction of the stroke volume of a pump. During a fluid processing procedure, the change in volume of a fluid in a container associated with a volume measurement system is calculated for a plurality of time periods. The standard deviation of the plurality of changes in volume is calculated, with it being determined that the volume measurement system is operating correctly when the standard deviation is below a target threshold. Upon determining that the volume measurement system is operating correctly, the stroke volume of the pump is calculated and a target change in volume of the fluid in the container is compared to an actual change in volume. When there is a difference between the two changes in volume, a correction factor is calculated, with the operation of the pump being adjusted based at least in part on the correction factor.
Methods and systems for the manual collection of whole blood are disclosed. The methods and systems include delivering a replacement fluid to the donor after or during the course of the blood collection.
Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).
A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller determines a total blood volume for a donor based on donor weight, height and gender. The system comprises a touchscreen for receiving a confirming user input and a scanning device configured to scan a bar code associated with a donor. The system and method operate a plurality of draw and return phases.
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
G08B 3/10 - Audible signalling systemsAudible personal calling systems using electric transmissionAudible signalling systemsAudible personal calling systems using electromagnetic transmission
G08B 5/22 - Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electric transmissionVisible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electromagnetic transmission
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
67.
ADMINISTERING A DRUG TO A PATIENT WITH AN INFUSION PUMP
Changing a data set on an infusion pump may use a processing circuit which receives infusion pump history data from a plurality of infusion pumps, the infusion pump history data comprising a reprogram event and an override event. A plurality of the reprogram events and the override events are stored in a memory. Display data is generated for presentation on a display indicating, for a drug, a number of infusion events that occurred for the drug, a number of override events that occurred for the drug, a percentage of override events that occurred for the drug, a number of reprogram events that occurred for the drug, and a percentage of reprogram events that occurred for the drug. After generating the display data, a change is received to a data set, the data set is downloaded to the infusion pump, and the infusion pump administers a drug to the patient.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
68.
SYSTEMS AND METHODS FOR OPTIMIZATION OF PLASMA COLLECTION VOLUMES
A system and a method for collecting plasma has a separator, a donor line, an anticoagulant line, a touchscreen, and a controller. The controller controls operation of the system and receives donor parameters electronically from a donor management system. The controller uses a target volume for plasma product and/or raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for plasma product and/or raw plasma based on the total donor blood volume. The controller controls the system to operate at least three draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and the red blood cells and to return the red blood cells to the donor
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 1/38 - Removing constituents from donor blood and returning remainder to body
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
69.
BEDSIDE CELL PROCESSING SYSTEM HAVING A REINFUSION SYSTEM
A bedside cell processing system including an apheresis system configured to collect from a patient a blood component comprising target cells, a cell processing system configured to receive the target cells from the apheresis system and to process the target cells, and a reinfusion system configured to receive the processed target cells and to return the processed cells to the patient. A method of operating a bedside cell processing system for a patient also is provided, including operating the apheresis system to collect from the patient via a collection flow path a blood component comprising target cells, operating a cell processing system to receive the target cells via a collected target cells flow path and to process the target cells, operating the reinfusion system to receive the processed target cells via a processed target cells flow path and to return the processed target cells to the patient.
A plasma storage container includes a bottle, with a connector (which may be unitarily formed) connected to a neck of the bottle. A gasket may be positioned between the neck and the connector to provide a seal along an interface therebetween. Inlet and outlet tubes are connected (e.g., via bonding) to the connector, with the connector defining an inlet flow path from the inlet tube to the interior of the bottle and an outlet flow path from the interior of the bottle to the outlet tube. A bottom end of the inlet flow path may extend farther into the interior of the bottle than the bottom end of the outlet flow path.
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes DetailsAccessories therefor
71.
Device Screen Interaction Using a Scanner and Bidirectional Data Transfer
A biological fluid processing system and a method of executing a biological fluid processing procedure is disclosed. The biological fluid processing system includes a processing device, a scanner, and a data management system. The processing device includes a display screen and a controller which operates the processing device to implement a biological fluid processing procedure having a plurality of steps. The controller displays an image on the display screen. The scanner interacts with the device screen to retrieve data from the image and transmit the data to the data management system. The scanner and/or the data management system transmit a signal to the controller based on the data. The controller initiates at least one step of the biological fluid processing procedure upon receiving the signal.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
A biological fluid processing device includes pump and valve systems, a centrifuge and a controller. The controller is configured to operate the pump and valve systems to convey buffy coat into the centrifuge, operate the centrifuge at a first rotation rate to separate the buffy coat into platelets and red blood cells, operate the pump and valve systems to convey a first portion of the separated platelets from the centrifuge for collection, and operate the pump and valve systems to convey the separated red blood cells from the centrifuge for collection. The controller is further configured to operate the centrifuge at one or more second rotation rates lower than the first rotation rate, operate the pump and valve systems to convey the collected red blood cells into the centrifuge, and operate the pump and valve systems to convey a second portion of the platelets from the centrifuge for collection.
Methods and systems for performing an apheresis procedure with a reduced risk of citrate reaction occurrences are described. The volume of body water in the apheresis subject is used to predict the likelihood of a citrate reaction during infusion of a blood component to the subject and allows for establishing and maintaining an optimal flow rate of the infused blood component.
Systems are provided for collecting, separating, concentrating and modifying blood components from whole blood for reinfusion. The system includes a blood processing device and a fluid flow circuit.
Systems are provided for collecting, sorting, and concentrating blood components from whole blood for reinfusion. The system may further include cell modification. The system includes a blood processing device and a fluid flow circuit.
A method of processing blood includes receiving from a touch screen user input data for a protocol for a wash procedure. The user input data includes a numeric value. The method includes storing the protocol in a memory, receiving an identifier from a user, determining if the identifier permits the user to modify the protocol and receiving a modification of the protocol from the user. The method includes providing a plurality of authorizations, a second authorization being a default and an administrator authorization permitting the user to change a setting. The method includes comparing a password to a password stored in memory and, if there is a match, determining that the password is associated with an administrator. If a command to change the setting is received, the command is applied to change the setting. The blood is processed employing a wash procedure using the modified protocol and the changed setting.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61M 1/26 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes which are moving
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
77.
Apparatus, systems and methods for storing, treating and/or processing blood and blood components
Apparatus, systems and methods are disclosed relating to certain aspects of blood processing, collecting or storing, including method and system for automated authentication, processing device with scanner, blood container with two dimensional barcode, blood collection containers, blood container label and related tracking method, integrated container system, and processing device with sterile connection device.
A packaging tray for use in a blood processing system including a blood processing device having device components arranged on a component surface and a removable fluid flow circuit having circuit components configured to interact with corresponding device components, wherein the packaging tray configured to be selectively arranged on and removable from the component surface. The packaging tray includes a first surface and a second surface opposite to the first surface and spaced apart by a thickness, component sections arranged at positions corresponding to positions of respective device components, the component sections respectively formed, at least partially, as openings extending through the thickness, and a plurality of recessed pathways formed on the first surface, the recessed pathways extending between the component sections. A blood processing device may include the packaging tray, and a blood processing system may include a blood processing device and the packaging tray.
A fluid distribution system for distributing fluid between a plurality of containers. The system includes a fluid circuit, stopcocks, and fluid containers, wherein the stopcocks are configured to control flow of fluid through the fluid circuit and the distribution of fluid between the plurality of containers.
Blood is conveyed from a source into a separator, which separates at least one target blood component from the blood. The target blood component is then conveyed out of the separator, with the procedure continuing until an initial target amount of blood to be processed has been conveyed from the source into the separator and the target blood component separated from the initial target amount of blood to be processed has been conveyed out of the separator as an actual yield of the target blood component. An adjusted target amount of blood to be processed is then determined based at least in part on the difference between a target yield of the target blood component and the actual yield. The initial target amount of blood to be processed is then replaced with the adjusted target amount of blood to be processed when next executing the procedure.
A system and method for collecting plasma comprises a control circuit configured to control operation of the system, the control circuit configured to receive one or more donor parameters. The control circuit estimates a physiological fluid amount of the donor based at least in part on the one or more donor parameters and calculates a target amount of plasma product comprising raw plasma and anticoagulant by multiplying a prestored constant by the estimated physiological fluid amount. The control circuit controls the system to operate draw and return phases to process whole blood into plasma product until a measured amount of plasma product in the collection container meets the target amount of plasma product.
Systems and methods are provided for collecting a platelet product having a target concentration. First and second target concentrations are first selected. Blood is then separated into red blood cells and platelet-rich plasma, with the platelet-rich plasma then being separated into platelet-poor plasma and platelet concentrate. At least a portion of the platelet concentrate is collected in a container as a platelet product having an actual platelet concentration, attempting to collect platelet concentrate having the first target concentration. After separation of the blood has been completed, at least a portion of the platelet-poor plasma and/or an additive solution is pumped into the container to decrease the concentration of the platelet product from the actual platelet concentration to the second target concentration.
A configurable automated blood component manufacturing system includes a durable hardware component and a single use fluid flow circuit. The hardware component includes a pump station, a centrifuge, and a controller including a touchscreen. The hardware component further includes hangers for suspending containers, a weight scale associated with each hanger, a plurality of tubing clamps, and a cassette nesting module including a plurality of valves and pressure sensors. The fluid flow circuit includes a separation chamber received in the centrifuge, a fluid flow control cassette mounted in the cassette nesting module, and a plurality of containers in fluid communication with the fluid flow cassette. The controller is pre-programmed to automatically operate the system to perform one or more standard blood processing procedures selected by an operator by input to the touchscreen, and is configured to be further programmed by the operator to perform additional blood processing procedures.
Systems and methods are provided to recover residual biological fluid from a soft sided fluid filter having an inlet and an outlet and which is used by a biological fluid processing system, including a reusable hardware unit comprising a fluid filter compression assembly. The fluid filter compression assembly further includes a housing having an outer wall that defines a housing space that receives the fluid filter, at least one bladder positioned within the housing space, at least one conduit, at least one pump, wherein the at least one conduit is in fluid communication with the at least one bladder and the at least one pump, and at least one clamp configured to selectively stop flow through the fluid filter inlet.
A centrifuge includes a yoke driven at a rotational speed with respect to a stationary frame of the centrifuge by a drive shaft extending from a motor. A timing belt engages a stationary sun gear and a planet gear, with rotation of the yoke rotating the timing belt and the planet gear. A shaft is associated with the planet gear, with rotation of the planet gear causing the shaft and an associated first sheave to rotate within and with respect to the yoke. Another timing belt engages the first sheave, with rotation of the first sheave causing the second timing belt and a second sheave to rotate with respect to the yoke. A receptacle rotates with the second sheave to cause a fluid separation chamber to rotate with respect to the stationary frame at a speed that is double the rotational speed at which the drive shaft is driven.
A distributed computing system for managing blood collection procedures in a blood collection facility includes a system server including a memory and a communication interface, the system server configured to store data identifiers for a plurality of different human operators. A plurality of computerized blood collection instruments are configured to collect blood from donors to generate collected products, each blood collection instrument comprising a communication interface configured to transmit data regarding the blood collection instrument to the system server. The system server stores data identifiers for each blood collection instrument. A computer is coupled to the system server and configured to present a dashboard for improving operational performance at and/or across blood collection facilities. The dashboard displays procedure data, data regarding the plurality of different human operators and data tracking each operator's activities or performance on a display.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G06Q 10/0637 - Strategic management or analysis, e.g. setting a goal or target of an organisationPlanning actions based on goalsAnalysis or evaluation of effectiveness of goals
G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
87.
SYSTEM AND METHOD FOR PREVENTING PATIENT REACTIONS DURING BLOOD DRAW
A method and system for drawing and collecting blood and/or blood components is disclosed. The method and system include a patient temperature monitoring device for monitoring a patient's temperature throughout a collection procedure, which includes an infrared camera. The infrared camera may be calibrated regularly to ensure accurate measurements.
A system and method for splitting a fluid into fluid products with a component count within a designated component count range and volume within a designated volume range. The method includes measuring an initial component concentration of a source container, weighing a source container to determine the volume of fluid, calculating the final component count and final volume for each of the source and at least one satellite container, calculating the amount of component additive solution to add the source container and flowing the amount of component additive solution from a component additive solution container into the source container, and splitting the fluid so that each divided fluid amount has a final component count within a designated component count range and a final volume within a designated volume range.
A system for altering blood flowrate during donation comprising a height adjustable blood collection assembly including: a base, a tower extending upward from the base, an actuator and a carrier; the actuator is coupled to the carrier and the tower, and the actuator vertically adjusts the carrier relative to the base; a receptacle being connected to the carrier and configured to receive a blood collection container; and a controller that interacts with at least the actuator.
A blood processing device includes a pump system, a valve system, a centrifuge, and a controller configured and/or programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping blood into the centrifuge, separating the blood in the centrifuge into red blood cells and plasma, and collecting portions of the separated red blood cells and plasma. Subsequently, a portion of the collected red blood cells is pumped back into the centrifuge to collect an additional amount of the separated plasma. A buffy coat or white blood cell layer may be formed between the separated red blood cells and plasma in the centrifuge. If so, a portion of the collected plasma may be pumped back into the centrifuge to harvest the buffy coat or white blood cell layer.
A blood processing device includes a pump system, a valve system, a centrifuge, and a controller configured and/or programmed to control the operation of the pump system, the valve system, and the centrifuge to execute a blood separation procedure. The blood separation procedure executed by the controller includes pumping blood into the centrifuge at an inflow rate, separating the blood in the centrifuge into red blood cells and plasma, with an interface between the red blood cells and plasma located at an interface position within the centrifuge, and pumping at least a portion of the red blood cells and at least a portion of the plasma out of the centrifuge. The controller is configured and/or programmed to employ an inflow rate and/or an interface position that is based at least in part on the temperature of the blood.
A method of processing blood or a blood product using an automated system includes displaying on a display a listing of a plurality of blood processing procedures that may be performed using the system and receiving operator input selecting one of the blood processing procedures that is to be performed. The method includes displaying on the display a list of parameters that are associated with the selected blood processing procedure and receiving operator input selecting a plurality of the parameters that are to populate the display during performance of the procedure. The method includes receiving operator input indicating a format in which the selected parameters are to be presented on the display. The method includes displaying values for the selected plurality of parameters in the indicated format during performance of the specified procedure.
A61M 1/34 - Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
93.
Centrifugal separation and collection of red blood cells and plasma
Systems and methods are provided for separating blood into two or more components for collection of red blood cells, plasma, or both red blood cells and plasma. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit, with the blood being separated into its constituents by the centrifugal separator. Separated plasma may be collected following separation by the centrifugal separator or may first be conveyed from the centrifugal separator into the spinning membrane separator drive unit to separate cellular blood components from the plasma prior to collection of the filtered plasma. The cellular blood components filtered from the plasma may be retained in the circuit as a waste product or may be flushed out of the circuit to a recipient.
A method for determining a total volume of anticoagulant required for performing a plasmapheresis procedure prior to connecting the donor to the fluid flow circuit, by determining: a total blood volume for a donor, volume of plasma to be collected, a volume of anticoagulant that will be collected together with the plasma and estimating a separation efficiency for the blood separator. Then calculating volume of anticoagulant to be returned to the donor based on the separation efficiency, total volume of anticoagulant to be used and suggesting and attaching either a single container or multiple containers of anticoagulant based on said calculations. The system comprises a touch screen for receiving input and providing said calculation of a total volume of anticoagulant needed for the procedure, and recommendation the number of containers of anticoagulant needed.
A method and system for donating blood and/or blood components is disclosed. The method and system include at least one adjustment mechanism to alter at least one feature of a blood draw in order to minimize and/or prevent donor reactions.
A head-mounted display device for interface with a medical device includes a frame configured to be mounted on a user's head, a display, a wireless transceiver configured to communicate with a network, and a processing circuit. The medical device is configured to perform an invasive procedure on the person. The processing circuit receives a notification message from the medical device. The processing circuit records medical device information in response to receiving the notification message from the medical device.
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
Blood donation frequency is optimized by incentive structures uniquely tailored to individual blood donors. An incentive structure may include incentive offers of different values, with each value being based at least in part on the predicted quality of a blood product produced from blood donated by the donor on a particular date. The structure may alternatively or additionally include one or more incentive offers that are each valued based at least in part on the predicted likelihood of the donor having an adverse reaction to a blood donation occurring on a particular date. The structure may alternatively or additionally include one or more incentive offers that are each valued based at least in part on the predicted likelihood of an attempted blood donation by the target donor being deferred on a particular date.
Medical containers and disposable fluid circuits (kits) including such containers are disclosed. The containers and kit components are made of a plastic composition including polyvinyl chloride and one or more plasticizers such as a citrate ester and an epoxidized vegetable oil are disclosed. Containers made from such compositions are useful in the storage red blood cells. Red blood cell products wherein the red blood cells exhibit a reduced level of hemolysis are also disclosed.
The pressure of fluid being conveyed through a fluid flow path during a biological fluid procedure is detected during the procedure. The fluid is conveyed through the fluid flow path 1) at a first pre-determined rate if pressure is zero to a first pressure threshold; 2) at the first pre-determined rate if pressure is greater than the first pressure threshold but less than or equal to a second pressure threshold and if an immediately preceding rate is equal to the first pre-determined rate; 3) at a second pre-determined rate if pressure is greater than the first pressure threshold but less than or equal to the second pressure threshold and if an immediately preceding rate is equal to the second pre-determined rate; and 4) at the second pre-determined rate if pressure value is greater than the second pressure threshold but less than or equal to a third pressure threshold.
An optical plasma grading system includes a broadband light source configured to emit light having wavelengths in a visible spectrum, an optical spectrometer configured to receive a reflected portion of the emitted light and analyze at least a portion of the received, reflected light to determine a main wavelength of the portion of the received reflected light, and a controller operably connected to the optical spectrometer, the controller configured to determine a plasma grade of the plasma based at least upon the main wavelength of the plasma.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
