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Résultats pour
 brevets
1.
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USE OF 5-AZACYTIDINE TO INHIBIT NONSENSE-MEDIATED RNA DECAY (NMD)
| Numéro d'application |
EP2014059658 |
| Numéro de publication |
2014/180996 |
| Statut |
Délivré - en vigueur |
| Date de dépôt |
2014-05-12 |
| Date de publication |
2014-11-13 |
| Propriétaire |
- EMBL (Allemagne)
- RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG (Allemagne)
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| Inventeur(s) |
- Bhuvanagiri, Madhuri
- Hentze, Matthias
- Lewis, Joe
- Kulozik, Andreas
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Abrégé
The invention relates to the use of 5-azacytidine and pharmaceutically acceptable salts thereof in a method of treating or preventing diseases responsive to inhibition of nonsense-mediated mRNA decay, such as cystic fibrosis, muscular dystrophy, autosomal dominant polycystic kidney disease (ADOKD), ataxia telangiectasia, β039-thalassemia, cancer, factor VII deficiency, familial atrial fibrillation, hemophilia B, hepatic carnitine palmitoyltransferase 1A deficiency (CPT1A), heritable pulmonary arterial hypertension (HPAH), late infantile neuronal ceroid lipofuscinosis (LNCL), leukocyte adhesion deficiency I (LAD1 ), methylmalonic academia (MMA), Hurler syndrome, nephropatic cystinosis, obesity, peroxisome biogenesis disorder (PBD), renal tubular acidosis (RTA), retinitis pigmentosa (RP), Rett syndrome (RTT), spinal muscular atrophy (SMA), Stuve-Wiedemann syndrome (SMS), X-linked nephrogenic diabetes insipidus (XNDI), or Usher syndrome (USH 1 ).
Classes IPC ?
- A61K 31/706 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle
- A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
- A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
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2.
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UNNATURAL AMINO ACIDS COMPRISING A CYCLOOCTYNYL OR TRANS-CYCLOOCTENYL ANALOG GROUP AND USES THEREOF
| Numéro d'application |
EP2012051885 |
| Numéro de publication |
2012/104422 |
| Statut |
Délivré - en vigueur |
| Date de dépôt |
2012-02-03 |
| Date de publication |
2012-08-09 |
| Propriétaire |
EMBL (Allemagne)
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| Inventeur(s) |
- Lemke, Edward
- Schultz, Carsten
- Plass, Tilman
- Milles, Sigrid
- Koehler, Christine
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Abrégé
The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans- cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans- cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5- tetrazine group.
Classes IPC ?
- C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
- C07C 11/00 - Hydrocarbures non saturés acycliques
- C07C 11/22 - Hydrocarbures non saturés acycliques comportant des liaisons triples carbone-carbone
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3.
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UNNATURAL AMINO ACIDS COMPRISING A CYCLOOCTYNYL OR TRANS-CYCLOOCTENYL ANALOG GROUP AND USES THEREOF
| Numéro de document |
02826041 |
| Statut |
Délivré - en vigueur |
| Date de dépôt |
2012-02-03 |
| Date de disponibilité au public |
2012-08-09 |
| Date d'octroi |
2020-07-07 |
| Propriétaire |
EMBL (Allemagne)
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| Inventeur(s) |
- Lemke, Edward
- Schultz, Carsten
- Plass, Tilman
- Milles, Sigrid
- Koehler, Christine
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Abrégé
The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans- cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans- cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5- tetrazine group.
Classes IPC ?
- C07C 11/00 - Hydrocarbures non saturés acycliques
- C07C 11/22 - Hydrocarbures non saturés acycliques comportant des liaisons triples carbone-carbone
- C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
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