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Found results for
 patents
1.
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USE OF 5-AZACYTIDINE TO INHIBIT NONSENSE-MEDIATED RNA DECAY (NMD)
| Application Number |
EP2014059658 |
| Publication Number |
2014/180996 |
| Status |
In Force |
| Filing Date |
2014-05-12 |
| Publication Date |
2014-11-13 |
| Owner |
- EMBL (Germany)
- RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG (Germany)
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| Inventor |
- Bhuvanagiri, Madhuri
- Hentze, Matthias
- Lewis, Joe
- Kulozik, Andreas
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Abstract
The invention relates to the use of 5-azacytidine and pharmaceutically acceptable salts thereof in a method of treating or preventing diseases responsive to inhibition of nonsense-mediated mRNA decay, such as cystic fibrosis, muscular dystrophy, autosomal dominant polycystic kidney disease (ADOKD), ataxia telangiectasia, β039-thalassemia, cancer, factor VII deficiency, familial atrial fibrillation, hemophilia B, hepatic carnitine palmitoyltransferase 1A deficiency (CPT1A), heritable pulmonary arterial hypertension (HPAH), late infantile neuronal ceroid lipofuscinosis (LNCL), leukocyte adhesion deficiency I (LAD1 ), methylmalonic academia (MMA), Hurler syndrome, nephropatic cystinosis, obesity, peroxisome biogenesis disorder (PBD), renal tubular acidosis (RTA), retinitis pigmentosa (RP), Rett syndrome (RTT), spinal muscular atrophy (SMA), Stuve-Wiedemann syndrome (SMS), X-linked nephrogenic diabetes insipidus (XNDI), or Usher syndrome (USH 1 ).
IPC Classes ?
- A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
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2.
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UNNATURAL AMINO ACIDS COMPRISING A CYCLOOCTYNYL OR TRANS-CYCLOOCTENYL ANALOG GROUP AND USES THEREOF
| Application Number |
EP2012051885 |
| Publication Number |
2012/104422 |
| Status |
In Force |
| Filing Date |
2012-02-03 |
| Publication Date |
2012-08-09 |
| Owner |
EMBL (Germany)
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| Inventor |
- Lemke, Edward
- Schultz, Carsten
- Plass, Tilman
- Milles, Sigrid
- Koehler, Christine
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Abstract
The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans- cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans- cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5- tetrazine group.
IPC Classes ?
- C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
- C07C 11/00 - Acyclic unsaturated hydrocarbons
- C07C 11/22 - Acyclic unsaturated hydrocarbons containing carbon-to-carbon triple bonds
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3.
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UNNATURAL AMINO ACIDS COMPRISING A CYCLOOCTYNYL OR TRANS-CYCLOOCTENYL ANALOG GROUP AND USES THEREOF
| Document Number |
02826041 |
| Status |
In Force |
| Filing Date |
2012-02-03 |
| Open to Public Date |
2012-08-09 |
| Grant Date |
2020-07-07 |
| Owner |
EMBL (Germany)
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| Inventor |
- Lemke, Edward
- Schultz, Carsten
- Plass, Tilman
- Milles, Sigrid
- Koehler, Christine
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Abstract
The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans- cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans- cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5- tetrazine group.
IPC Classes ?
- C07C 11/00 - Acyclic unsaturated hydrocarbons
- C07C 11/22 - Acyclic unsaturated hydrocarbons containing carbon-to-carbon triple bonds
- C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
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