Disclosed herein is a nutritional composition having at least one protein, at least one fat, and at least one lipophilic compound, the composition comprising at least one assembly comprising at least one hydrophobic protein, monoglycerides and diglycerides (“MDG”) and at least one lipophilic compound, wherein at least 1% of the total MDG in the nutritional composition remains in the aqueous phase after centrifugation at 100,000×g for 1 hour at 20° C.
Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs). Embodiments may include a shift of a diffractive order.
A biostimulator includes a housing having a longitudinal axis and containing an electronics compartment. A pacing element is coupled to the housing. The pacing element includes a conductor extending along the longitudinal axis to a pacing tip. The biostimulator includes a sheath surrounding the conductor. The sheath includes one or more protrusions extending radially outward from an outer sheath surface.
A medical device including stabilizing wires that are selectively movable from a first and second position and a delivery system including the same are described herein. The medical device includes a device body and the stabilizing wires coupled thereto. Each stabilizing wire has a proximal and distal end. In the first position, at least a portion of the distal end extends radially outwardly from the device body, and in the second position, the distal end is retracted within the device body. Each stabilizing wire includes a linear portion at the proximal end, a hook portion at the distal end, and a ramp segment extending between the linear portion and the hook portion, including a ramp incline portion that extends at a first angle from the linear portion to a ramp apex, and a ramp decline portion that extends at a second angle from the hook portion to the ramp apex.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
5.
SYSTEM AND METHOD FOR IDENTIFYING REGIONS OF HETEROGENEOUS CARDIAC ELECTRICAL PROPAGATION
e.g.e.g., via an electroanatomical mapping system) of identifying regions of heterogeneous cardiac electrical propagation for treatment of arrhythmia via application of ablation therapy includes receiving a cardiac activation map, generating an activation direction entropy map from the activation map, and generating an output based on the activation direction entropy map, wherein the output includes an identification of one or more regions of heterogeneous cardiac electrical propagation. The activation direction entropy values may be based upon a distribution of activation directions within a sub-region of the patient's heart and may further be normalized to an entropy score between 0 and 1. The output may be generated using a volumetric convolutional neural network algorithm or a particle swarm optimization algorithm.
A system for performing a transcatheter heart valve replacement in a patient may include a delivery catheter having an inflatable balloon on a distal portion of the delivery catheter, and a distal tip at a distal end of the delivery catheter. A collapsible and expandable prosthetic heart valve is configured to be crimped on the balloon while the balloon is deflated in a delivery condition of the delivery catheter. An introducer has a proximal hub sized to remain outside of the patient, and a sheath extending distally from the proximal hub and sized to receive the delivery catheter therethrough while the delivery catheter is in the delivery condition. A lubricant is applied to one or more of (i) an outer surface of the delivery catheter, (ii) an outer surface of the prosthetic heart valve, or (iii) an inner surface of the introducer.
Methods, devices, systems, and kits are provided that buffer the time spaced glucose signals in a memory, and when a request for real time glucose level information is detected, transmit the buffered glucose signals and real time monitored glucose level information to a remotely located device, process a subset of the received glucose signals to identify a predetermined number of consecutive glucose data points indicating an adverse condition such as an impending hypoglycemic condition, confirm the adverse condition based on comparison of the predetermined number of consecutive glucose data points to a stored glucose data profile associated with the adverse condition, where confirming the adverse condition includes generating a notification signal when the impending hypoglycemic condition is confirmed, and activate a radio frequency (RF) communication module to wirelessly transmit the generated notification signal to the remotely located device only when the notification signal is generated.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
8.
SYSTEMS, DEVICES, AND METHODS FOR IMPROVED ANALYTE SENSOR ACCURACY AND FAULT DETECTION
Various embodiments of systems, devices and methods for improving the accuracy of an analyte sensor and for detecting sensor fault conditions are disclosed. According to some embodiments, these systems, devices, and methods can utilize a first data collected by a glucose sensor and a second data collected by a secondary sensing element. In some embodiments, the secondary sensing element can be one of a lactate sensing element, a ketone sensing element, or a heart rate monitor, among others.
Improved ophthalmic lenses, particularly intraocular lenses (IOLs). Examples may include lenses configured to have optical performance that varies in response to an accommodative stimulus.
A flexible electrode includes a flexible, electrically insulative substrate, a bonding layer disposed on a first surface of the substrate, a conductive layer disposed on a second surface of the substrate, and a via through the bonding layer and the substrate that exposes a portion of the reverse surface of the conductive layer. The exposed portion of the reverse surface can be secured (e.g., soldered) to a conductive contact, such as a conductive pill, on an exterior surface of a catheter shaft. The flexible electrode can then be wrapped around the exterior surface of the shaft to form a ring electrode and the bonding layer can be bonded to the catheter shaft, such as by reflow bonding.
Integrated glucose monitoring systems, comprising a memory configured to store data relating to at least two glucose measurements of a user, a glucose safe range, and exogenous data. Wherein the at least two glucose measurements of the user are at different time points t1 and t2; a user interface comprising a display; and a processor comprising computer-executable instructions. Wherein the computer-executable instructions determine a rate of change based on the at least two glucose measurements of the user; determine, based on the at least two glucose measurements of the user and the determined rate of change, a projected glucose level at a future time t3; and provide an alarm at the user interface if, based on at least one point of exogenous data, the projected glucose level at future time t3 is outside of the glucose safe range.
G06F 16/28 - Bases de données caractérisées par leurs modèles, p. ex. des modèles relationnels ou objet
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
13.
Systems and Methods for Enhancing Access and Delivery for TAVR
A system for performing a transcatheter heart valve replacement in a patient may include a delivery catheter having an inflatable balloon on a distal portion of the delivery catheter, and a distal tip at a distal end of the delivery catheter. A collapsible and expandable prosthetic heart valve is configured to be crimped on the balloon while the balloon is deflated in a delivery condition of the delivery catheter. An introducer has a proximal hub sized to remain outside of the patient, and a sheath extending distally from the proximal hub and sized to receive the delivery catheter therethrough while the delivery catheter is in the delivery condition. A lubricant is applied to one or more of (i) an outer surface of the delivery catheter, (ii) an outer surface of the prosthetic heart valve, or (iii) an inner surface of the introducer.
Applicator including a housing; a sensor carrier coupled to the housing, and including a first lock interface; a sheath, slidably coupled to the housing, the sheath including a first lock arm having an attached distal end and a free proximal end, the free proximal end including a first lock arm interface disposed on an inner surface of the first lock arm and a first sharp edge disposed on an outer surface of the first lock arm; and a cap threadably coupled to the housing, the cap including an inner surface having a first plurality of crush ribs. The inner surface of the cap is configured to urge the first lock arm inwardly such that the first lock arm interface engages the first lock interface; and the first sharp edge is configured to engage the first plurality of crush ribs during a shock event.
Analyte sensors featuring an enzyme system comprising diaphorase and a NAD-dependent dehydrogenase may be utilized to detect inhibitors of diaphorase, provided that the transfer of electrons to a working electrode is rate-limiting with respect to the diaphorase. Such analyte sensors may comprise a sensor tail comprising at least a first working electrode, a first active area disposed upon a surface of the first working electrode, and an analyte-permeable membrane overcoating at least the first active area. The enzyme system comprises NAD, reduced NAD, or any combination thereof; a NAD-dependent dehydrogenase, such as NAD-dependent glucose dehydrogenase; and diaphorase. Inhibitors of diaphorase that may be detected include, for example, warfarin, dicoumarol, and similar compounds. A second active area may be present to facilitate detection of an analyte differing from the inhibitor of diaphorase.
A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques en utilisant des électrodes enzymatiques, p. ex. avec oxydase immobilisée
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
16.
SYSTEMS AND METHODS FOR DETEMINATION OF LENS MECHANICAL PROPERTIES
Methods may include causing a plurality of image sensors to capture one or more first images of a lens disposed in or on a lens holder. The lens may be under a first compression force applied along a radial axis. The lens holder may be configured to support the lens, while one or more mechanical loads are applied to the lens. Methods may include causing the plurality of image sensors to capture one or more second images of the lens under a second compression force applied along the radial axis. The second compression force may be different from the first compression force. Methods may include determining one or more mechanical properties of the lens based on the first images and the second images. The mechanical properties may include one or more of: compression force, axial displacement, optic decentration, optic tilt, or angle of contact.
G01N 3/08 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique par application d'efforts permanents de traction ou de compression
17.
SYSTEMS AND METHODS FOR DETECTION OF BULK DEFECTS ON A OPHTHALMIC LENSES
Methods may include receiving image data captured by an image sensor and may include a plurality of image slices captured at a plurality of height measurements. Methods may include determining a contour of a subject lens in one or more of the plurality of image slices. Methods may include determining, based at least on the respective contour of the subject lens, a center of the subject lens in one or more of the plurality of image slices. Methods may include aligning, based at least on the respective center of the subject lens in the one or more of the plurality of image slices, the plurality of image slices resulting in an aligned plurality of image slices. Methods may include causing an aggregation of the aligned plurality of image slices to be displayed. The aggregation may indicate a through-height representation of the subject lens.
A medical device system may include a guidewire with a proximal end configured to be controlled by an operator to advance a distal end of the guidewire that includes at least one guidewire electrode. A medical device system also includes a processor coupled to the at least one guidewire electrode and configured to perform one or more of measurements and therapy delivery using the at least one guidewire electrode.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
Produits et services
Nutritionally fortified beverages for medical purposes; Liquid nutritional supplement; Dietetic supplements adapted for medical purposes; Nutritional supplement shakes; Dietary supplement beverage for human consumption in liquid form for therapeutic purposes; Protein supplement shakes Dairy-based food beverages
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
Produits et services
Nutritionally fortified beverages for medical purposes; Dietetic beverages adapted for medical use; Liquid nutritional supplement; Nutritional supplement shakes; Dietary supplement beverage for human consumption in liquid form for therapeutic purposes; Protein supplement shakes Dairy-based food beverages
21.
FOCUSED STERILIZATION AND STERILIZED SUB-ASSEMBLIES FOR ANALYTE MONITORING SYSTEMS
A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.
A lead for an implantable medical device (IMD) includes an electrode having a plurality of brick segments that are discrete and mechanically connected to one another in a line. The brick segments are electrically conductive and electrically connected to one another. The brick segments are configured to be powered by a pulse generator of the IMD to deliver high-voltage shocks for defibrillation therapy.
A system for disrupting calcium within a blood vessel includes a handle, a balloon catheter extending from the handle, a balloon positioned at a distal end portion of the balloon catheter, and a fluid reservoir in fluid communication with a lumen, the lumen being in fluid communication with an interior volume of the balloon. The system also includes a motor operably coupled to the fluid reservoir, and a pressure sensor fluidically in contact with the fluid reservoir and configured to sense a pressure within the balloon. The motor is configured to alternately (i) push fluid from the fluid reservoir through the lumen toward the interior volume of the balloon and (ii) withdraw fluid from the interior volume of the balloon toward the fluid reservoir, so as to cycle between balloon inflation and deflation to repeatedly press the balloon against an interior surface of the blood vessel.
Example embodiments of systems, devices, and methods are described for communication in an analyte monitoring system in accordance with an applicable communication protocol. A first device of the system may transmit a command to a second device of the system and the second device may encounter a processing delay in preparing data responsive to the command. The second device may transmit dummy data to the first device in order to maintain compliance with the communication protocol until such time that the second device is ready to transmit data responsive to the command. Numerous different embodiments for incorporating and/or accommodating the presence of dummy data in a communication hierarchy are provided.
H04L 45/02 - Mise à jour ou découverte de topologie
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
H04B 5/79 - Systèmes de transmission en champ proche, p. ex. systèmes à transmission capacitive ou inductive spécialement adaptés à des fins spécifiques pour le transfert de données en combinaison avec le transfert d'énergie
H04W 4/80 - Services utilisant la communication de courte portée, p. ex. la communication en champ proche, l'identification par radiofréquence ou la communication à faible consommation d’énergie
H04W 12/03 - Protection de la confidentialité, p. ex. par chiffrement
Lenses and methods are provided for improving peripheral and/or central vision for patients who suffer from certain retinal conditions that reduce central vision or patients who have undergone cataract surgery. The lens is configured to improve vision by having an optic configured to focus light incident along a direction parallel to an optical axis at the fovea in order to produce a functional foveal image. The optic is configured to focus light incident on the patient's eye at an oblique angle with respect to the optical axis at a peripheral retinal location disposed at a distance from the fovea, the peripheral retinal location having an eccentricity between −30 degrees and 30 degrees. The image quality at the peripheral retinal location is improved by reducing at least one optical aberration at the peripheral retinal location. The method for improving vision utilizes ocular measurements to iteratively adjust the shape factor of the lens to reduce peripheral refractive errors.
An implantable biostimulator has a housing, one or more fixation elements at a distal end of the housing, and one or more electrode probes. The housing includes an electronics compartment containing pacing circuitry. The one or more electrode probes are coupled to the pacing circuitry. The one or more electrode probes are extendable from the distal end of the housing. The one or more electrode probes have depth control to a controlled depth of extension.
A biostimulator transport system includes a sheath having a distal sheath end. The biostimulator transport system includes a deployment tube extending from the distal sheath end to a distal tube end. The biostimulator transport system includes an expandable structure having a ventricle-shaped envelope surrounding the deployment tube. The ventricle-shaped envelope includes a front boundary coupled to the distal tube end and a rear boundary coupled to the distal sheath end. The front boundary and the rear boundary are joined along one or more of a bottom edge and lateral edges.
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
A61N 1/375 - Aménagements structurels, p. ex. boîtiers
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
28.
SYSTEMS AND METHODS FOR ELECTROPORATION USING WAVEFORMS THAT REDUCE ELECTRICAL STIMULATION
A pulse generator for use with an electroporation system is provided. The pulse generator is configured to be coupled to a catheter including a plurality of electrodes and is configured to generate a waveform to be delivered using at least one of the plurality of electrodes. The waveform includes a pulse train having positive and negative pulses, wherein an average charge over the pulse train is zero.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A system for disrupting calcium within a blood vessel includes a handle, a balloon catheter extending from the handle, a balloon positioned at a distal end portion of the balloon catheter, and a fluid reservoir in fluid communication with a lumen, the lumen being in fluid communication with an interior volume of the balloon. The system also includes a motor operably coupled to the fluid reservoir, and a pressure sensor fluidically in contact with the fluid reservoir and configured to sense a pressure within the balloon. The motor is configured to alternately (i) push fluid from the fluid reservoir through the lumen toward the interior volume of the balloon and (ii) withdraw fluid from the interior volume of the balloon toward the fluid reservoir, so as to cycle between balloon inflation and deflation to repeatedly press the balloon against an interior surface of the blood vessel.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/22 - Instruments pour comprimer les ulcères ou similaires placés sur les organes internes du corpsInstruments pour curer les cavités des organes du corps, p. ex. des osInstruments, dispositifs ou procédés chirurgicaux pour l'élimination ou la destruction invasives des calculs utilisant des vibrations mécaniquesInstruments, dispositifs ou procédés chirurgicaux pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
30.
SYSTEMS AND METHODS OF UTILIZING SENSE CHANNELS CONNECTED TO A PLURALITY OF ELECTRODES
A computer-implemented method includes measuring, using a first sense channel, a first electrode impedance signal associated with a first electrode. The method further includes measuring, using a second sense channel, a second electrode impedance signal associated with at least a second and third electrode, wherein the second and third electrodes are electrically connected to each other but not to the first electrode. The method further assesses tissue contact/proximity based on the first electrode impedance signal and the second electrode impedance signal.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/10 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour poser ou retirer les clamps pour blessuresChargeurs de clamps pour blessures
Systems, methods and apparatus are provided for rejecting noise from sparsely sampled analyte sensor data. Embodiments of the present disclosure include receiving a raw set of sensor data from an on-body device including an in vivo analyte sensor, determining an interpolation-based estimate of an analyte level over time based on the raw set of sensor data, determining an extrapolation-based estimate of the analyte level over time based on the raw set of sensor data, determining a combined estimate of the analyte level over time based on the interpolation-based estimate and the extrapolation-based estimate, and displaying a representation of the combined estimate of the analyte level over time on an output device. Numerous additional aspects are disclosed.
Sensor control device for analyte monitoring comprising electronics housing having shell defining top surface and mount defining bottom surface of the electronics housing. Adhesive patch coupled to the bottom surface defines central opening, and includes first layer facing the mount and second layer facing skin of user. The first layer has first aperture, second layer has second aperture, and the first aperture and second aperture align with central opening along vertical axis of the sensor control device. First layer or second layer includes laser cut slots or laser cut holes configured for drainage of fluid or breathability of skin.
Systems, devices, and methods for detecting, measuring and classifying meals for an individual based on analyte measurements. These results and related information can be presented to the individual to show the individual which meals are causing the most severe analyte response. These results can be organized and categorized based on preselected criteria or previous meals and results so as to organize and present the results in a format with reference to glucose as the monitored analyte. Various embodiments disclosed herein relate to methods, systems, and software applications intended to engage an individual by providing direct and timely feedback regarding the individual's meal-related glycemic response.
A leadless biostimulator, such as a leadless cardiac pacemaker, having a header assembly that includes overmolded components, is described. The header assembly includes a helix mount overmolded on a flange of an electrical feedthrough assembly. A fixation element is mounted on the helix mount. The overmolded helix mount fills a recess in an outer surface of the flange to robustly join the header assembly components. The electrical feedthrough assembly includes an electrode contained within the flange to deliver electrical impulses to a target anatomy, and an insulator that separates the electrode from the flange. The overmolded helix mount can conform or adhere to the outer surfaces of the flange and the insulator to electrically isolate the electrode from the flange. Other embodiments are also described and claimed.
An indeflator (1200) for a balloon inflation system, the indeflator having a moving member (1210) and a barrel (1250) having a fluidcontaining portion defining an internal space to receive a fluid. The indeflator is configured to receive a desired fill volume with high accuracy and precision. The filled indeflator can be used to accurately and precisely expand a medical device crimped on an inflatable.
A mold is used to form a solder joint to join the distal end of the guidewire to a wire coil. The mold has a cavity that can have different configurations so that the solder joint can be any of bullet shaped, micro-J shaped, cone shaped, truncated cone shaped, or have a textured surface.
B21F 15/08 - Assemblage de fils métalliques entre eux ou à d'autres matériaux ou objets métalliquesAssemblage d'éléments au moyen de fils métalliques de fils entre eux avec d'autres éléments ou matériaux de connexion utilisant le soudage ou le brasage
B22D 18/02 - Coulée avec pression, utilisant des dispositifs presseurs mécaniques, p. ex. matriçage semi-liquide
B22D 19/04 - Coulée dans, sur, ou autour d'objets formant partie intégrante du produit final pour raccorder des pièces
B23K 1/08 - Brasage par immersion dans un bain de métal fondu
Described herein are implantable medical devices (IMDs), and methods for use therewith. In certain embodiments, a controller of an IMD controls when a pacing capacitor of the IMD is charged using a first voltage, when the pacing capacitor is being charged using a second voltage, and when the pacing capacitor is discharged to deliver a pacing pulse between anode and cathode electrodes of, or electrically coupled to, the IMD. By selectively charging the pacing capacitor for a portion of a charge duration using the second voltage, that is greater in magnitude than the first voltage that is used for delivering the pacing pulse, a magnitude of a polarization artifact superimposed on an evoked response within a cardiac electrical signal, sensed using a sensing circuit of the IMD, is reduced compared to if the pacing capacitor were instead charged using the first voltage for the entire charge duration.
A medical device manufacturing process can include inserting a hollow shaft having a longitudinally-extending slit into the central lumen of a tubular device body, leaving its distal end protruding beyond the device body. The shaft includes an inner layer of a first material and an outer layer of a second material; the second material melts at a lower temperature than the first material. A sensor stack (14), including alternately-disposed spacing elements (14) and sensors (28), is formed around the protruding segment of the shaft. The spacing elements include an inner layer (34a) of a third material and an outer layer (34b) of a fourth material; the third material melts at a lower temperature than the fourth material. The assembly bonded by heating it above the melting temperatures of the second and third materials but below the those of the first and fourth materials.
A method of conducting a virtual clinic (VC) session between a patient and a clinician to facilitate medical services using a VC cloud computing system is provided. The method comprises receiving video data from a patient controller (PC) device of the patient, the video data including patient gait data of the patient acquired by the PC device during the VC session, identifying, from the received video data, at least one fixed edge in an environment surrounding the patient, determining, based on the at least one identified fixed edge, an amount of camera tilt of the PC device relative to the patient, normalizing anatomical landmark data of the patient gait data by applying a transformation to the anatomical landmark data to compensate for the determined amount of camera tilt, and providing the normalized anatomical landmark data to one or more trained computation models to classify one or more patient gait characteristics.
A shaping tool is used to form a bend in the distal end of a guidewire. The guidewire distal end is inserted through a channel and into a cavity of the shaping tool. Using hand pressure, a fist member is moved axially relative to a second member of the shaping tool, thereby moving the cavity relative to the channel and imparting a bend in the distal end of the guidewire.
A system for managing a patient's glucose level includes a glucose sensor to generate and store data signals for measurements of the patient's glucose level made by the glucose sensor; an insulin pump; and sensor electronics operatively coupled to the glucose sensor, the sensor electronics comprising a memory storing one or more predetermined characteristics associated with the sensor electronics; and a computing device in electronic communication with the sensor electronics. The computing device comprises a processor configured to operate the sensor electronics to (i) receive the generated data signals, (ii) obtain the one or more predetermined sensor characteristics from the memory and (iii) execute a closed-loop algorithm to provide insulin delivery instructions to an insulin pump by at least using the data signals and predetermined characteristics.
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
44.
Valve Repair Clip with Automatic Locking Mechanism Activation
A mitral valve clip includes a stud, a lock, and two arms. The stud includes a shank, and the lock includes a frame relative to which the stud is translatable and into which the shank extends. The lock is able to prevent movement of the stud relative to the lock in at least one direction by locking engagement of the shank. The two arms are connected to the lock and the stud such that an angle between the arms depends on a location of the stud relative to the lock. The locking engagement of the shank that prevents movement of the stud relative to the lock in the at least one direction is only possible when the angle between the arms is below a predefined locking threshold.
This application is generally related to identifying or otherwise programming one or more cycling parameters for operation of an implantable pulse generator to provide a neurostimulation therapy to a patient using a non-paresthesia stimulation pattern. In some embodiments, the cycling parameter is selected by measuring physiological signals during trial stimulation. In other embodiments, multiple cycling parameters are identified for use by the patient using a patient controller device.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/06 - Électrodes pour traitement à haute fréquence
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
A glucose data analysis system includes an on-body unit and a processor. The on-body unit is configured to measure glucose levels of a user. The processor is configured to receive therapy data of the user including glucose data monitored by the on-body unit, analyze daily glucose profiles of the glucose data over an analysis period by a machine learning model, group the daily glucose profiles into two or more patterns based on the analysis performed by the machine learning model, and output a report including identification of the two or more patterns associated with each daily glucose profile. Advantageously the system may identify and visualize patterns of glucose data, identify recurring patterns, identify correlations between patterns and external events (e.g., medication, meals, exercise, sleep, stress, etc.), reduce glycemic variability, streamline analysis with unsupervised machine learning (e.g., no training), and provide recommendations for user intervention or actions based on identified patterns.
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
47.
SYSTEMS, DEVICES, AND METHODS WITH DURATION-BASED ADJUSTMENT OF SENSOR DATA
Embodiments that compensate for changes to sensor response characteristics (e.g., sensitivity) due to time durations are disclosed. The time durations can be the amount of time the sensor is in a post-manufacture packaged state prior to use, or the amount of time the sensor is in use. Sensor response changes due to other variables can also be compensated for.
A61B 5/1495 - Étalonnage ou test des sondes in vivo
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p. ex. pour planifier la maintenance ou les mises à jour
48.
METHODS, DEVICES, AND SYSTEMS FOR ADJUSTING LABORATORY HBA1C VALUES
A method of providing personalized treatment for a diabetes patient including a remote device which is configured to receive a first data indicative of an analyte level of a subject during a first time period, retrieve a first glycated hemoglobin level for the subject associated with the first time period, calculate a first personal apparent glycation ratio for the first time period using the received first data and the retrieved first glycated hemoglobin level, compare the calculated first personal apparent glycation ratio to a representative apparent glycation ratio, generate a recommendation based on the comparison, and display a graphical interface comprising the calculated first personal apparent glycation ratio, the representative apparent glycation ratio, and the comparison.
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
ST JUDE MEDICAL INTERNATIONAL HOLDING S.À R.L. (Luxembourg)
Inventeur(s)
Izmirli, Alon
Hevel, Guy
Herscovici, Adrian
Vaknin, Yuval
Jacobs, David
Abrégé
Aspects of the present disclosure are directed to apparatuses for generating a magnetic field for tracking of a target object. Such an apparatus may include a localized magnetic field transmitter that generates a magnetic field and exhibits minimal X-ray absorption when used in proximity to a fluoroscopic imaging system, for example.
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/283 - Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électrocardiographie [ECG] invasives
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
G01R 33/30 - Dispositions pour le traitement des échantillons, p. ex. cellules d'essai, mécanismes rotationnels
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing an Internet website portal featuring information for use by healthcare personnel in the field of electrophysiology medicine, namely, case images, videos, and compiled analytics from external capital equipment, electronic medical records, and patient health records available via a cloud-based repository.
An implantable medical device includes a body and a coating. The body has a metal surface. The coating is deposited on the metal surface of the body. The coating includes a bonding layer and a polymer layer. The bonding layer includes a first layer comprising a first silane coupling agent and a second layer comprising a second silane coupling agent. The first layer is deposited on the metal surface, and the second layer is deposited on the first layer. The polymer layer is deposited on the second layer. The first silane coupling agent is capable of forming a stronger bond with the metal surface of the body than with the polymer layer. The second silane coupling agent is capable of forming a stronger bond with the polymer layer than the metal surface.
Aspects of the disclosure provide a delivery device for a prosthetic heart valve, the delivery device includes a retaining element with a recess arranged to receive a corresponding tab of the prosthetic heart valve. The recess may be shaped to progressively reduce contact with the respective tab as the prosthetic heart valve expands from its collapsed condition to its expanded condition. The recess may include a tapered base. The retaining element may include one or more secondary recesses arranged to receive one or more struts of the prosthetic heart valve. A prosthetic heart valve may also be provided, in which the tab is set at an angle directed away from a plane of struts connecting the tab and/or the tab may include a biasing element arranged to bias the tab away from the recess when the tab is in the recess.
A medical device for occluding a left atrial appendage, LAA, the medical device comprising a single occlusive member configured to occlude an ostium of the LAA in a deployed condition of the medical device, wherein the occlusive member is a disc-shaped portion, and wherein the medical device is configured to be attached only to the ostium of the LAA.
A system for securing tissue includes a fixation device and a piezoelectric sensing system. The fixation device includes a center portion and a first clamp extending from the center portion. The first clamp is comprised of a first proximal element and a first distal element. The piezoelectric sensing system includes a first piezoelectric sensor coupled to one of the first distal element, the first proximal element, and the center portion. A signal processing unit of the sensing system includes a power source and a signal processing module. The signal processing module is configured to receive signals from the first piezoelectric sensor corresponding to a parameter associated with pressure, process the received signals, and generate an output signal indicative of the parameter. An interface is configured to couple the first piezoelectric sensor to the signal processing unit for transmitting the signals from the first piezoelectric sensor to the signal processing unit.
56.
APPARATUS AND METHODS FOR TRANSSEPTAL CATHETERIZATION
A transseptal catheterization apparatus includes an electrically-conductive core, an energy delivery element at the distal end of the core, a coil or insulative filler surrounding at least a portion of the core, and an insulative jacket surrounding at least a portion of the core. The coil may be radially adjacent the core with the insulative jacket surrounding the coil. Alternatively, the insulative jacket may be radially adjacent the core and the coil may surround the insulative jacket. The energy delivery element may be a tip electrode conductively coupled to the core. An insulative bushing may be positioned between the tip electrode and the coil to electrically isolate the tip electrode from the coil. The exterior surface(s) of the energy delivery element and/or the coil may be dimpled or roughened.
A glucose data analysis system includes an on-body unit and a processor. The on-body unit is configured to measure glucose levels of a user. The processor is configured to receive therapy data of the user including glucose data monitored by the on-body unit, analyze daily glucose profiles of the glucose data over an analysis period by a machine learning model, group the daily glucose profiles into two or more patterns based on the analysis performed by the machine learning model, and output a report including identification of the two or more patterns associated with each daily glucose profile. Advantageously the system may identify and visualize patterns of glucose data, identify recurring patterns, identify correlations between patterns and external events (e.g., medication, meals, exercise, sleep, stress, etc.), reduce glycemic variability, streamline analysis with unsupervised machine learning (e.g., no training), and provide recommendations for user intervention or actions based on identified patterns.
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 15/00 - TIC spécialement adaptées aux rapports médicaux, p. ex. leur création ou leur transmission
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
58.
ANALYTE SENSORS WITH A SENSING SURFACE HAVING SMALL SENSING SPOTS
Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/1473 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques invasifs, p. ex. introduits dans le corps par un cathéter
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
A fixation device for fixation of heart valve leaflets includes a central assembly and an arm moveably coupled to the central assembly. The arm includes a body portion having a first end and a second end and a longitudinal axis defined therebetween. The body portion has opposing body lateral sides, each body lateral side extending between the first end and the second end. Further, the body portion has a body portion width defined between the opposing body lateral sides. The fixation device further includes a size adapter attached to the arm, the size adapter having a maximum undeformed arm lateral cross-dimension defined between outer lateral edges of the size adapter. The ratio between the body portion width and the maximum undeformed arm lateral cross-dimension is at least about 1:1.8 to about 1:2.2. The fixation device further includes at least one gripping element.
A61B 17/04 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations pour la suture des plaiesSupports ou emballages pour aiguilles ou matériaux de suture
An implantable medical device is disclosed herein and can be in the form of an implantable medical lead or a leadless pulse generator. The implantable medical device includes a body, at least one electrode and a tube-cut helical fixation anchor. The body includes a distal end and a proximal end opposite the distal end. The at least one electrode is supported on the body. The tube-cut helical fixation anchor distally extends from the distal end. The tube-cut helical fixation anchor may be fixed or extendable/retractable relative to the distal end. The tube-cut helical fixation anchor may be a result of a manufacturing process comprising cutting the tube-cut helical fixation anchor from a thin-walled tubular body.
A system for occluding a left atrial appendage (“LAA”) includes a delivery device and an LAA occluder. The LAA occluder has an indicator electrode coupled to a connector electrode via a conducting wire. The delivery device has a connector with a connector electrode configured to be coupled to a navigation system via a conducting wire. During implantation, the delivery device is coupled to the LAA occluder so that the connector electrodes are electrically coupled, resulting in the indicator electrode being conductively coupled to the navigation system. After the LAA occluder is deployed into the LAA, the delivery device is disconnected from the LAA occluder to allow the LAA occluder to remain in the patient.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
62.
FIXATION DEVICES AND SYSTEMS WITH TISSUE CAPTURE INDICATION FEATURES
A fixation device includes a center assembly and first and second clamps extending outwardly from the center assembly. Each clamp includes an anchor member and a gripper disposed opposite the anchor member. The gripper includes an indicator arm and a retention arm. The indicator arm and retention arm are independently moveable between a raised position and an engagement position. The retention arm has a length greater than a length of the indicator arm.
A system for occluding a left atrial appendage ("LAA") includes a delivery device and an LAA occluder. The LAA occluder has an indicator electrode coupled to a connector electrode via a conducting wire. The delivery device has a connector with a connector electrode configured to be coupled to a navigation system via a conducting wire. During implantation, the delivery device is coupled to the LAA occluder so that the connector electrodes are electrically coupled, resulting in the indicator electrode being conductively coupled to the navigation system. After the LAA occluder is deployed into the LAA, the delivery device is disconnected from the LAA occluder to allow the LAA occluder to remain in the patient.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
In some embodiments, a delivery device includes a catheter extending between a proximal end and a distal end, and an inflatable balloon disposed at the distal end of the catheter, the inflatable balloon having an eccentricity of between 0.1 and 0.7 in an inflated state absent external forces.
A61F 2/958 - Instruments spécialement adaptés pour insérer ou retirer les stents ou les endoprothèses déployables couvertes ballons gonflables pour insérer les stents ou les endoprothèses déployables couvertes
A balloon-expandable prosthetic heart valve includes a collapsible and expandable stent comprising a plurality of commissure attachment features, and a valve assembly coupled to the collapsible and expandable stent, the valve assembly comprising a plurality of leaflets, an outer cuff configured to promote tissue ingrowth and an inner cuff having an inner surface and an outer surface, the inner surface of the inner cuff having a different ingrowth profile than the outer surface of the inner cuff.
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
66.
PROSTHETIC VALVES DESIGNED FOR THROMBUS AND IN-VIVO THICKENING
In some embodiments, a prosthetic heart valve, includes a stent having a longitudinal axis, an inner cuff coupled to a luminal surface of the stent, an outer cuff coupled to an abluminal surface of the stent, and a plurality of leaflets coupled to the stent, each of the plurality of leaflets being configured to reduce a risk of hyper-attenuated leaflet thickening.
In some embodiments, a prosthetic heart valve, includes a stent having a longitudinal axis, at least one of an inner cuff and an outer cuff coupled to the stent, the at least one of the inner cuff and the outer cuff having an inflow end, an outflow end and a connecting zone where two side edges extending along the longitudinal axis of the stent are coupled; and a suture pattern coupling the two side edges at the connecting zone, the suture pattern having a set of stitches chosen from horizontal stitches and diagonal stitches.
In some embodiments, a prosthetic heart valve, includes a stent having a plurality of cells and a plurality of commissure attachment features, portions of each of the plurality of commissure attachment features being moveable relative to the plurality of cells, a cuff coupled to the stent, and a plurality of leaflets, the cuff and the plurality of leaflets forming a valve assembly, each of the plurality of leaflets having two leaflet attachment tabs coupled to ones of the plurality of commissure attachment features.
A medical device for occluding a left atrial appendage ("LAA") may include a proximal occluding member to cover an ostium of the LAA and a distal occluding member to be received within a cavity of the LAA. A connecting member may connect the proximal occluding member to the distal occluding member. An occluding material may be uncoupled from the proximal occluding member in a delivery condition of the proximal occluding member, and uncoupled from the distal occluding member in a delivery condition of the distal occluding member, the occluding material configured to at least partially fill and occlude the LAA. In some examples, the distal occluding member is entirely excluded, and the medical device includes other anchoring provisions, such as tethers that latch onto a back wall of the LAA.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
70.
Display screen or portion thereof with graphical user interface
A system for electrical stimulation of a dorsal root ganglion is disclosed. The system comprises a paddle body extending between a proximal end and a distal end; a lead body extending from the proximal end; an electrode array disposed on at least one surface of the paddle body, the electrode array having one or more electrode contacts arranged in a two-dimensional electrode array configuration forming an asymmetrical paddle lead with the electrical stimulation focused in a single direction within a target area of the dorsal root ganglion; and a living hinge formed by the paddle body extending from a first side to a first hinge and from a second side to a second hinge, the first and second hinges each forming a joint configured to bend the paddle body along a contour to cradle the dorsal root ganglion.
Various embodiments of systems, devices and methods for identifying meal start and meal peak response candidates are described. The methods include a set of meal start candidates and meal peak response candidates based on user-initiated analyte checks and analyte data from an analyte monitoring system.
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
G16H 20/60 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant le contrôle de l’alimentation, p. ex. les régimes
74.
NUTRITIONAL COMPOSITIONS COMPRISING HUMAN MILK OLIGOSACCHARIDES AND NUCLEOTIDES AND USES THEREOF FOR TREATING AND/OR PREVENTING ENTERIC VIRAL INFECTION
Disclosed are nutritional compositions including human milk oligosaccharides and nucleotides that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.
A61K 31/702 - Oligosaccharides, c.-à-d. ayant trois à cinq radicaux saccharide liés les uns aux autres par des liaisons glycosidiques
A23L 33/00 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement
A23L 33/125 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sirops d'hydrate de carboneModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sucresModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des alcools de sucreModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des hydrolysats d'amidon
A61K 31/7068 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique
A61K 31/7072 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique ayant deux groupes oxo liés directement au cycle pyrimidine, p. ex. uridine, acide uridylique, thymidine, zidovudine
A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p. ex. adénosine, acide adénylique
A61K 31/708 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p. ex. adénosine, acide adénylique ayant des groupes oxo liés directement au système cyclique purine, p. ex. guanosine, acide guanylique
Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor, such as a dermal sensor, for sensing an analyte level in a bodily fluid of a subject. An applicator is positioned against a skin surface and a force is applied to the applicator causing at least a portion of a sharp and an in vivo analyte sensor to be positioned in the body of the subject. In particular, disclosed herein are embodiments of applicators designed to prevent premature sharp withdrawal and/or reduce the likelihood of improper sensor insertion. Also disclosed are embodiments of applicators including sharp modules having an angled sharp which can be configured to create an insertion path for a sensor.
COMPOSITIONS AND METHODS FOR THE DETECTION AND ANALYSIS OF HERPES SIMPLEX VIRUS 1 (HSV-1), HERPES SIMPLEX VIRUS 2 (HSV-2) AND VARICELLA ZOSTER VIRUS (VZV)
Provided herein are compositions and methods useful for the detection of Herpes Simplex Virus 1 (HSV-1), Herpes Simplex Virus 2 (HSV-2) and Varicella Zoster Virus (VZV). In particular, provided herein are compositions, methods, systems, kits, reagents, and reaction mixtures involving such for nucleic acid amplification and detection procedures that detect HSV-1, HSV-2 and VZV in samples.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
77.
SYSTEM FOR DISCRIMINATING BETWEEN MAGNETIC FIELDS USING AN IMPLANTED MEDICAL DEVICE
An implantable medical device (IMD) is provided that can include electronic circuitry, a first sensor configured to detect a magnetic field in an environment of the IMD, and a second sensor configured to obtain environmental data. The IMD can also includes one or more processors, and a memory coupled to the one or more processors. The memory stores program instructions, wherein the program instructions are executable by the one or more processors to discriminate between a first magnet mode and a second magnet mode based on the environmental data and switch the mode of operation with the electronic circuitry based on discriminating between the first magnet mode and the second magnet mode.
A transseptal catheterization apparatus includes an electrically-conductive core, an energy delivery element at the distal end of the core, a coil or insulative filler surrounding at least a portion of the core, and an insulative jacket surrounding at least a portion of the core. The coil may be radially adjacent the core with the insulative jacket surrounding the coil. Alternatively, the insulative jacket may be radially adjacent the core and the coil may surround the insulative jacket. The energy delivery element may be a tip electrode conductively coupled to the core. An insulative bushing may be positioned between the tip electrode and the coil to electrically isolate the tip electrode from the coil. The exterior surface(s) of the energy delivery element and/or the coil may be dimpled or roughened.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A medical device is provided in which one or both ends of the device encourage the formation of tissue across substantially the entire area of the respective end that is exposed to the blood flow for reducing the risk of a thrombotic embolism. The medical device includes a tubular structure having at least one expanded volume portion and a tapered transition portion. The tubular structure may be made through the braiding of a number of strands, and a first end feature may be used to secure the proximal strand ends. The proximal strand ends may be secured via the proximal end of the first end feature, such that the tapered transition portion is formed over the circumferential surface of the first end feature, and only a proximal end surface (or a portion of the proximal end surface) of the first end feature is exposed to the path of flowing blood.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A fixation device includes a first distal element and a first proximal element. The first distal element and first proximal element each have a first end and a second end and are moveable relative to each other. First and second electrodes are coupled to either the first distal element or the first proximal element between the first and second ends thereof. The electrodes at least partially form a circuit. The circuit is an open circuit generating a first impedance response when tissue contacts the first electrode and not the second electrode. The circuit is a closed circuit generating a second impedance response when tissue contacts the first and second electrode. The first impedance response has a first impedance value greater than a second impedance value of the second impedance response.
A method of conducting operations for an IPG adapted to provide electrical pulses to tissue of a patient for medical therapy is provided. The IPG provides the medical therapy according to pulse parameter data executed according to an execution path. The method can include identifying a root node repeated within the execution path of a first set of the pulse parameter data, identifying a stimulation pulse pattern repeated in the first set between occurrences of the root node, replacing the repeated pattern with (a) a single instance and a recurrence count or (b) a pointer to a reference pattern to generate a second set of the pulse parameter data, and communicating the second set between the external controller and the IPG and/or storing the second set within a memory of the IPG.
A device and method for assessing rotational stability of an ophthalmic implant. The device includes a holder for receiving within a central portion thereof an ophthalmic implant to be tested. The holder is movable between a first position wherein a first compressive force is exerted on the ophthalmic implant when positioned within the central portion, and a second position wherein a second compressive force is exerted on the ophthalmic implant. The device further includes a drive mechanism coupled to the holder and capable of imparting a reciprocating motion to the holder between the first and second positions.
An implantable lead is described herein that includes a lead body, a fixation helix, and a ring electrode. A proximal end of the lead body is configured to be connected to an implantable medical device. The fixation helix projects beyond a distal end of the lead body to penetrate tissue of a patient. The lead body includes a housing configured to burrow into the tissue of the patient with the fixation helix. The housing is mounted to the ring electrode and extends to the distal end of the lead body. The housing includes a housing helix along an outer surface of the housing, which defines a portion of an exterior surface of the implantable lead. The housing helix has first turns that circumferentially wrap around the housing. The first turns have a common rotational direction as second turns of the fixation helix.
A delivery device including a handle, a sheath defining a lumen and extending distally from the handle, and a hemostasis valve positioned at a proximal end of the handle, the hemostasis valve being located proximal the sheath, the hemostasis valve being rotatable relative to at least one of the sheath and the handle.
The present disclosure relates to catheters comprising a catheter shaft comprising a proximal end and a distal end, and a flexible tip portion comprising an expandable flexible framework comprising a plurality of electrode-carrying arms, wherein each of the plurality of electrode-carrying arm converges with at least one other of the plurality of electrode-carrying arm at a distal apex of the flexible tip portion and wherein each of the plurality of electrode-carrying arms comprises a shape-memory material, and a plurality of electrodes mounted on the electrode-carrying arms. An inflatable balloon is positioned within the expandable flexible framework and is selectively inflatable to adjust the expandable flexible framework from a first non-expanded configuration in which the plurality of electrode-carrying arms form a flexible, substantially planar array, to a second expanded configuration securing a position of the plurality of electrode-carrying arms in an expanded array.
A mitral valvuloplasty balloon catheter includes a handle, a catheter (240+250) extending from the handle, and a balloon (200) operably coupled to a distal end portion of the catheter, the balloon having an inflated condition and a deflated condition. In the inflated condition of the balloon, the balloon includes an atrial end (220), a ventricular end (230) distal to the atrial end, and a waist portion (210) between the atrial end and the ventricular end. The ventricular end (230) has a diameter that is between about 1.4 and about 2.2 times larger than a diameter of the waist portion (210).
A61F 2/958 - Instruments spécialement adaptés pour insérer ou retirer les stents ou les endoprothèses déployables couvertes ballons gonflables pour insérer les stents ou les endoprothèses déployables couvertes
A pull wire assembly for a steerable medical device includes a wire lock and a wire. The lock includes a core having a frustoconical outer surface and an annular collar including a frustoconical inner surface complementary to the outer surface of the core. The core is inserted into the collar. The wire is inhibited against distal movement by a compressive force arising within the wire lock when the frustoconical surfaces of the core and collar are forced against each other. The wire may be inserted into the lock between the collar and the core, such that it is pinned therebetween. Alternatively, the wire may be inserted through an interior of the core, such that it is pinned between pieces of the core, such as a plurality of tines or two halves of the core.
A pull wire assembly (30) for a steerable medical device includes a wire lock (32) and a wire (16). The lock includes a core (34) having a frustoconical outer surface (42) and an annular collar (36) including a frustoconical inner surface (44) complementary to the outer surface of the core. The core is inserted into the collar. The wire is inhibited against distal movement by a compressive force arising within the wire lock when the frustoconical surfaces of the core and collar are forced against each other. The wire may be inserted into the lock between the collar and the core, such that it is pinned therebetween. Alternatively, the wire may be inserted through an interior of the core, such that it is pinned between pieces of the core, such as a plurality of tines or two halves of the core.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Dietetic substances, namely infant formula and food for babies adapted for medical use; dietary, nutritional and food supplements for infants for general health and well-being in liquid and powder form; infant formula; food for babies.
The present disclosure includes methods, devices and systems for establishing a connection between a medical device and a remote computing device, receiving an upgrade command at the medical device, storing a current version of persistent data and a current version of executable code in a first storage area of the medical device, transmitting at least the current version of the persistent data to the remote computing device, receiving a second format of the current version of the persistent data and an upgraded version of executable code at the medical device, storing the second format of the current version of the persistent data and the upgraded version of the executable code in a second storage area of the medical device, and executing the upgraded version of the executable code with the second format of the current version of the persistent data.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p. ex. pour planifier la maintenance ou les mises à jour
G06F 8/654 - Mises à jour utilisant des techniques spécialement adaptées aux mémoires de masse réinscriptibles, p. ex. aux mémoires EEPROM ou flash
G06F 8/71 - Gestion de versions Gestion de configuration
G06F 11/10 - Détection ou correction d'erreur par introduction de redondance dans la représentation des données, p. ex. en utilisant des codes de contrôle en ajoutant des chiffres binaires ou des symboles particuliers aux données exprimées suivant un code, p. ex. contrôle de parité, exclusion des 9 ou des 11
G06F 11/14 - Détection ou correction d'erreur dans les données par redondance dans les opérations, p. ex. en utilisant différentes séquences d'opérations aboutissant au même résultat
Systems, devices, kits, and methods are provided herein in the form of example embodiments that relate to calibration of medical devices. The medical devices can be sensors adapted to sense a biochemical attribute. The embodiments can be used to determine calibration information specific to an individual medical device. The embodiments can determine the calibration information by reference to one or more parameters obtained during manufacturing of the medical device. The embodiments can also determine the calibration information by reference to in vitro testing of the medical devices. The embodiments also apply to systems incorporating those medical devices in their use in the field. Also described are embodiments of modifications to surfaces of sensor substrates, such as through applied radiation and/or the creation of a well, to aid in the placement and/or sizing of a sensor element on the substrate.
Methods and devices herein are provided for managing atrial (A) pacing in connection with premature atrial contracts (PAC). The methods and devices obtain an atrial pace-on-PAC (APAC) interval and cardiac activity (CA) signals. The methods and devices are configured to: i) during a first cardiac beat; following a ventricular paced (VP) or ventricular sensed (VS) event, activate a timer for a post ventricular-atrial refractory period (PVARP) interval; and determine whether a first atrial refractory (AR) event occurs during the PVARP interval; ii) during a second cardiac beat; in response to the detecting that the first AR event occurred, initiate an APAC interval; during the APAC interval for the second cardiac beat, determine whether a second AR event occurs; and update a count of APAC events when the second AR event occurs; and iii) repeat i) and ii) for multiple cardiac beats, to track the count of APAC events.
A61N 1/368 - Stimulateurs cardiaques commandés par un paramètre physiologique, p. ex. par le potentiel cardiaque comprenant plus d'une électrode coopérant avec différentes régions du cœur
Method and system for monitoring atrioventricular (AV) conduction and controlling pacing therapy includes determining atrial events for a series of heartbeats over a detection period using a leadless implantable medical device (LIMD) implanted in or on an atrial chamber of a heart. Surrogate AV intervals are determined for at least a portion of the atrial events over the detection period based on a signal indicative of ventricular activity. The surrogate AV intervals are trended over time to generate diagnostic data. The diagnostic data is evaluated against one or more criteria stored in at least one of the LIMD or an external device, and in response to the evaluation satisfying the one or more criteria, an action is initiated to modify an operational mode of at least one LIMD or to generate an alert. The action includes changing the operational mode of at least one LIMD or transmitting the alert to the external device.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/29 - Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électrocardiographie [ECG] invasives pour implantation permanente ou à long terme
A61B 5/36 - Détection de l’intervalle PQ, de l’intervalle PR ou de l’intervalle QT
A61N 1/368 - Stimulateurs cardiaques commandés par un paramètre physiologique, p. ex. par le potentiel cardiaque comprenant plus d'une électrode coopérant avec différentes régions du cœur
A prosthetic heart valve includes a frame and a plurality of prosthetic leaflets mounted within the frame. A first one of the plurality of prosthetic leaflets includes a fixation mechanism. The fixation mechanism may be configured to increase a maximum dimension of one of the plurality of leaflets over a period of time in situ. The fixation mechanism may alternatively or additionally restrict mobility of one or more of the prosthetic leaflets to induce regurgitation when the prosthetic heart valve is implanted. The fixation mechanism may transition over time so that the amount of intentional regurgitation reduces over time, including reducing to substantially zero regurgitation, or any other intentionally designed level of regurgitation. The intentional regurgitation may allow the heart to safely acclimate to new pressure dynamics over time after the implantation.
An IMD for a patient includes circuitry for providing a medical therapy to the patient and for sensing physiological activity of the patient, a battery for powering the IMD, one or more processors for controlling device operations, and wireless circuitry for communicating with one or more external devices. The IMD predicts a state and/or a capacity of the battery using the processors to generate an output of a computational model. The computational model receives at least one of: an electric characteristic of the battery related to storage, discharge, or charging; an intrinsic characteristic of the battery; a temperature characteristic; a usage characteristic and/or a communication characteristic of communication between the IMD and an external device. The IMD is adapted to communicate a signal indicative of the prediction for one or more of replacing or recharging the battery of the IMD using the wireless communication circuitry.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
98.
SYSTEMS AND METHODS FOR CONDUCTING DIGITAL HEALTH CONSULTATIONS AND FOR REMOTE PROGRAMMING OF MEDICAL DEVICES
A system and method for conducting a virtual clinic (VC) session between a patient and a clinician using a VC cloud telehealth system to program an implantable pulse generator (IPG) of a patient to provide a neurostimulation therapy to the patient. One or more VC session models or criteria can be defined that represent clinician and patient interactions during a VC session and a first communication connection can be established between a patient electronic device (PED) and the IPG of the patient. A second communication connection can also be established between a patient electronic device (PED) and the VC cloud telehealth system and a third communication connection can be established between a clinician electronic device (CED) and the VC cloud computing system to connect the patient and clinician for the VC session. Based on input from the clinician electrical stimulation for the neurostimulation therapy can be applied to the patient.
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 80/00 - TIC spécialement adaptées pour faciliter la communication entre les professionnels de la santé ou les patients, p. ex. pour le diagnostic collaboratif, la thérapie collaborative ou la surveillance collaborative de l’état de santé
99.
UNSUPERVISED MACHINE LEARNING PARADIGM TO CONTROL CARDIAC AND RESPIRATION RELATED MOTION ARTIFACTS
A method of filtering unwanted motion related artifacts from received sensor-based location data includes receiving unfiltered location data and calculating a plurality of spatio-temporal components associated with the unfiltered location data. The method further includes comparing each spatio-temporal component to the unfiltered location data and updating a weight value based on the comparison of each spatio-temporal component to the unfiltered location data to generate a dynamically updated set of weights. Motion corrected location data is calculated based on the dynamically updated set of weights and the plurality of spatio-temporal components.
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
A61B 5/113 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre se produisant au cours de la respiration
Provided are dermal sensors and dermal sensor applicator sets to insert at least a portion of a dermal sensor into a dermal layer of a subject, as well as methods of making and using the same.
A61B 5/1473 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques invasifs, p. ex. introduits dans le corps par un cathéter
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
