A fixation device includes a first distal element and a gripping device. The gripping device including a base section, a first bend feature, and a first proximal element. The first bend feature defining a first hinge axis. The first proximal element extending from the first bend feature and having a first section, a second section, and a first hinge disposed between the first section and the second section and defining a second hinge axis. The second section having a plurality of frictional elements extending therefrom and being rotatable about the second hinge axis between a first configuration and a second configuration.
A fixation device includes first and second distal elements and first and second proximal elements. The first and second proximal elements include a first elongate arm and a second elongate arm, respectively. The first and second elongate arms each include first and second side edges and plurality of frictional elements defining a plurality notches in the first and second side edges. The first and second proximal elements also each include first and second guard rails extending adjacent to and along the first and second side edges, respectively.
A system and method are provided for communication between first and second devices utilizing a predetermined protocol. The system and method utilize at least one of communication circuitry or a processor, within one of the first and second devices, for, receiving a data packet; determining whether the data packet exhibits an error; when the data packet exhibits the error, incorporating the data packet into a candidate packet register (CPR) within the one of the first medical device and the second device; analyzing a content the CPR for errors; and based on the analyzing, designating the content of the CPR to be a resultant packet and output the resultant packet as a corrected version of the data packet.
H04L 1/00 - Arrangements for detecting or preventing errors in the information received
H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
4.
TISSUE FIXATION DEVICE WITH ENHANCED TISSUE PROTECTION
A fixation device includes first and second distal elements and first and second proximal elements. The first and second proximal elements include a first elongate arm and a second elongate arm, respectively. The first and second elongate arms each include first and second side edges and plurality of frictional elements defining a plurality notches in the first and second side edges. The first and second proximal elements also each include first and second guard rails extending adjacent to and along the first and second side edges, respectively.
An implantable fixation device includes fixation elements and gripping elements for fixating tissue. A stud is coupled to the fixation elements and is configured such that movement of the stud moves the fixation elements within a range of positions. A binding plate is configured to engage the stud to arrest its movement and to disengage the stud to allow its movement. A biasing element engages the binding plate and biases the binding plate into engagement with the stud. A harness with a single foot is engaged to the binding plate is configured such that tensioning the harness moves the binding plate in opposition to the bias of the biasing element so as to release the binding plate from the stud. Releasing tension on the harness returns the binding plate into engagement with the stud and secures the fixation elements in one position within the range of positions.
A delivery system includes a delivery catheter that is releasably coupled to a fixation device and a delivery handle that is coupled to the delivery catheter. A lock control assembly of the delivery handle has a releasable lock line handle operable to lock and unlock components of the fixation device. The lock line handle has a shaft body and a lever arm that respectively define first and second openings. A lock line extending from the fixation device and through the delivery catheter has a first end portion fixedly coupled to the lock line handle and a second end portion that extends through the first and second openings. The lock line is free to move through the openings when the lever arm is in a first position and is secured when the lever arm is in a second position.
An implantable fixation device includes fixation elements and gripping elements for fixating tissue. A stud is coupled to the fixation elements and is configured such that movement of the stud moves the fixation elements within a range of positions. A binding plate is configured to engage the stud to arrest its movement and to disengage the stud to allow its movement. A biasing element engages the binding plate and biases the binding plate into engagement with the stud. A harness with a single foot is engaged to the binding plate is configured such that tensioning the harness moves the binding plate in opposition to the bias of the biasing element so as to release the binding plate from the stud. Releasing tension on the harness returns the binding plate into engagement with the stud and secures the fixation elements in one position within the range of positions.
A system for monitoring a physiologic condition of a patient includes an implantable medical device (IMD) comprising: an accelerometer configured to output an accelerometer signal; sensing circuitry configured to sense a cardiac activity (CA) signal; and a memory configured to store program instructions. One or more processors that, when executing the program instructions, are configured to: determine a heart rate (HR) at a point in time based on the CA signal; determine an activity level (AL) at the point in time based on accelerometer data that is based on the accelerometer signal, the HR and AL forming an HR-AL event; compare the HR-AL event to a heart condition (HC) metric that defines combinations of HRs and ALs representing a physiologically normal heart condition and a physiologically abnormal heart condition; and transmit the HR-AL event or a result of the comparison to a second device for use in diagnosing and/or treating a heart condition.
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
St. Jude Medical, Cardiology Division , Inc. (USA)
Inventor
Oliverius, Andrew
Hawkinson, Neil
Marass, Timothy S.
Welter, Wade
Strom, Nicholas
Butler, Quinn
Marrs, James
Abstract
Various embodiments of the present disclosure can include flexible catheter tip. The flexible catheter tip can include a flexible arm defining a longitudinal axis and including a first rectangular cross-section. An intermediate covering can be disposed about the flexible arm. The intermediate covering can include a first intermediate covering disposed about the flexible arm, a second intermediate covering disposed about the first intermediate covering, and a covering disposed over the intermediate covering such that the intermediate covering is disposed between the covering and the flexible arm. The first intermediate covering can include a heat shrink material. The intermediate covering and the covering can be non-conductive coverings and can extend about a circumference of the flexible arm.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/287 - Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
A method for fabricating a segmented electrode is provided. The method includes performing a series of progressive die stamping operations on a foil sheet of material to form an initial electrode, and removing portions of the initial electrode using a centerless grinding process to form a segmented electrode including a plurality of circumferentially spaced contacts.
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
B21D 22/02 - Stamping using rigid devices or tools
B21D 35/00 - Combined processes according to methods covered by groups
B23P 11/00 - Connecting or disconnecting metal parts or objects by metal-working techniques, not otherwise provided for
B23P 13/00 - Making metal objects by operations essentially involving machining but not covered by a single other subclass
H01R 43/16 - Apparatus or processes specially adapted for manufacturing, assembling, maintaining, or repairing of line connectors or current collectors or for joining electric conductors for manufacturing contact members, e.g. by punching and by bending
11.
TISSUE FIXATION DEVICE WITH IMPROVED TISSUE SECUREMENT
A fixation device includes a first proximal element and a first distal element. The first proximal element has a gridded frame disposed between a first end portion and a second end portion and a plurality frictional elements. The gridded frame has a plurality of axial struts and a plurality of transverse struts intersecting the axial struts to define a plurality of openings. At least some of the frictional elements extend from at least some of the transverse struts. The first distal element is disposed in opposition to the first proximal element and has a cavity disposed between a first end portion and a second end portion thereof. The cavity is configured to receive at least a portion of the gridded frame.
A system for cutting leaflet tissue at a cardiac valve may comprise a guide catheter having a proximal end and a distal end, wherein the distal end of the guide catheter is steerable to a position above a cardiac valve. The system may also include a handle coupled to the proximal end of the guide catheter, the handle comprising at least one control configured to steer the guide catheter to the position above the cardiac valve. Finally, the system may comprise a cutting mechanism routable through the guide catheter and able to be positioned at the distal end of the guide catheter, the cutting mechanism configured to cut a portion of leaflet tissue of the cardiac valve.
A delivery system and method are described that include an access introducer sheath and a delivery catheter. The access introducer sheath defines a channel through a body thereof from a proximal end to a distal end. The delivery catheter is disposed within the channel of the access introducer sheath, and defines a lumen that extends along a central axis of the delivery catheter. A distal end segment of the delivery catheter projects beyond the distal end of the access introducer sheath. The lumen is configured to receive a dilator therein that projects beyond the distal end of the delivery catheter so that the distal end segment of the delivery catheter is disposed between a tip segment of the dilator and the distal end of the access introducer sheath along the central axis.
A method may include implanting a prosthetic heart valve into a heart valve of the patient. The method may include generating a series of baseline fluoroscopic images of the target site under contrast encompassing at least one complete heartbeat cycle of the patient. The series of baseline fluoroscopic images may be annotated to provide an anatomical landmark annotation and/or a target annotation representing a target location for deploying the prosthetic heart valve. The prosthetic heart valve may be advanced toward the target site while mounted to or in a delivery device in a collapsed condition. Real-time fluoroscopic images of the target site may be generated while the prosthetic heart valve is located within the target site. The real-time fluoroscopic images may be displayed so that the anatomical landmark annotation and/or the target annotation is overlaid on the displayed images, and the prosthetic heart valve may be implanted.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
A deflectable catheter assembly including a handle, a catheter system, a method for determine deflection of a deflectable shaft section of the catheter. The catheter includes a handle coupled for deflecting the deflectable shaft section, and one or more pull wires to effect a deflection. The handle includes a housing, a deflection control coupled to the housing and operable to deflect the deflectable shaft section, and a deflection feedback assembly (e.g., a variable resistor) disposed within the housing. The deflection feedback assembly is coupled to the deflection control and configured to convert motion of the deflection control into a signal indicative of a degree of deflection of the deflectable shaft section. The deflection feedback assembly provides an active feedback regarding deflection of the deflectable shaft section to facilitate accurate positioning of the deflectable shaft section within a patient.
A method may include implanting a prosthetic heart valve into a heart valve of the patient. The method may include generating a series of baseline fluoroscopic images of the target site under contrast encompassing at least one complete heartbeat cycle of the patient. The series of baseline fluoroscopic images may be annotated to provide an anatomical landmark annotation and/or a target annotation representing a target location for deploying the prosthetic heart valve. The prosthetic heart valve may be advanced toward the target site while mounted to or in a delivery device in a collapsed condition. Real-time fluoroscopic images of the target site may be generated while the prosthetic heart valve is located within the target site. The real-time fluoroscopic images may be displayed so that the anatomical landmark annotation and/or the target annotation is overlaid on the displayed images, and the prosthetic heart valve may be implanted.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Embodiments described herein relate to an IMD operating in a backup mode in a manner that mitigates against adverse effects of a memory failure. The IMD includes a NVM that stores backup mode firmware, a RAM that includes multiple separate RAM blocks, a processor, and a counter. The processor executes the backup mode firmware to operate the IMD in accordance with a backup mode in response to detection of a malfunction that when detected should cause the IMD to operate in accordance with the backup mode. While the processor operates the IMD in accordance with the backup mode the processor stores and accesses variables in one of the RAM blocks. The counter is selectively incremented and used to select which one of the RAM blocks the variables are stored within while the processor executes the backup mode firmware to operate the IMD in accordance with the backup mode.
A prosthetic heart valve for replacing a native valve includes a stent extending between a proximal end and a distal end and including a plurality of struts forming cells, the stent having a collapsed condition and an expanded condition. At least one runner is coupled a cell, the at least one runner being configured to transition from a first configuration to a second configuration when the stent moves from the collapsed condition to the expanded condition, the at least one runner projecting radially outwardly from the cell in the second configuration. A valve assembly is disposed within the stent, the valve assembly including a plurality of leaflets, a cuff at least partially disposed on a luminal surface of the stent, and a covering material disposed on an abluminal surface of the stent and covering the at least one runner in the second configuration.
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
20.
BIOSTIMULATOR TRANSPORT SYSTEM HAVING LOCATION GUIDES
A biostimulator transport system includes a biostimulator coupling along a central axis, and one or more location guides. The location guides are deployable radially outward from the central axis. When deployed, the location guides engage anatomical landmarks. Other embodiments are also described and claimed.
A system and method for modeling patient-specific spinal cord stimulation (SCS) is disclosed. The system and method acquire impedance and evoked compound action potential (ECAP) signals from a lead positioned proximate to a spinal cord (SC). The lead includes at least one electrode. The system and method determine a patient-specific anatomical model based on the impedance and ECAP signals, and transform a dorsal column (DC) map template based on a DC boundary of the patient-specific anatomical model. Further, the system and method map the transformed DC map template to the patient-specific anatomical model. The system and method may also include the algorithms to solve extracellular and intracellular domain electrical fields and propagation along neurons. The system and method may also include the user interfaces to collect patient responses and compare with the patient-specific anatomical model as well as using the patient-specific anatomical model for guiding SCS programming.
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
22.
IMPLANTABLE MEDICAL SYSTEMS AND METHODS USED TO DETECT, CHARACTERIZE OR AVOID ATRIAL OVERSENSING WITHIN AN IEGM
Certain embodiments of the present technology described herein relate to detecting atrial oversensing, characterizing atrial oversensing, determining when atrial oversensing is likely to occur, and or reducing the chance of atrial oversensing occurring. Some such embodiments relate to specifying an atrial oversensing avoidance (AOA) period corresponding to when atrial oversensing may occur following one or more paced or sensed atrial events, and after specifying the AOA period selectively using an atrial oversensing avoidance technique during one or more instances of the AOA period that follow paced or sensed atrial events to thereby reduce a likelihood of atrial oversensing during the one or more instances of the AOA period.
A61B 5/33 - Heart-related electrical modalities, e.g. electrocardiography [ECG] specially adapted for cooperation with other devices
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
23.
METHOD AND SYSTEM FOR CALIBRATING SENSING CIRCUITRY OF AN IMPLANTED MEDICAL DEVICE
A system is provided that includes electrodes configured to be implanted in a body, and a pulse generator (PG) circuitry to deliver a stimulus to one or more of the electrodes. The system also includes sensing circuitry configured to define a sensing channel between one or more of the electrodes to sense signals indicative of a physiologic activity of interest, and the sensing circuitry further configured to collect a calibration signal over the sensing channel. The sensing circuitry and PG circuitry are housed within an implantable medical device (IMD). The system also includes one or more processors configured to determine a signal characteristic of interest (COI) of the calibration signal. The one or more processors are also configured to compare a signal COI of the stimulus to the signal COI of the calibration signal, and adjust a parameter of the sensing circuitry or PG circuitry based on the comparison.
In at least one embodiment, a system and method for implanting an implantable medical device (IMD) within a patient may include an IMD including a housing and an attachment member, and a delivery catheter including a tethering snare that is configured to be selectively extended out of the delivery catheter and retracted into the delivery catheter. In at least one embodiment, a system and method for implanting an implantable medical device (IMD) within a patient may include an IMD including a housing and an attachment member, wherein the attachment member includes a central passage connected to a connection chamber, and a delivery catheter including first and second tethers that may be moved outwardly from and retracted into the delivery catheter.
St. Jude Medical, Atrial Fibrillation Division, Inc. (USA)
Inventor
Just, Dale E.
Tegg, Troy T.
Johnson, Theodore A.
Hall, Sacha C.
Abstract
A family of catheter electrode assemblies includes a flexible circuit having a plurality of electrical traces and a substrate; a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the electrode. A non-contact electrode mapping catheter includes an outer tubing having a longitudinal axis, a deployment member, and a plurality of splines, at least one of the plurality of splines comprising a flexible circuit including a plurality of electrical traces and a substrate, a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the ring electrode. A method of constructing the family of catheter electrode assemblies is also provided.
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/08 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
The present disclosure provides analyte sensors comprising a first working electrode, a sensing area disposed upon a surface of the first working electrode, and a membrane that overcoats the sensing area, wherein the first sensing area comprises from about 0.19% to about 16% by weight of a surfactant. The present disclosure also provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample and methods of manufacturing the analyte sensors.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
27.
Catheter Assembly With Coaptation Aid And Methods For Valve Repair
Catheter assembly with a coaptation aid for repair of leaflets of a heart valve includes an elongate catheter shaft adapted to be positioned transvascularly proximate a heart valve and a lever coupled to the catheter shaft. The lever has a hinge to transition the lever between an elongate delivery configuration generally aligned longitudinally with the catheter shaft and a deployed configuration extending transversely from the catheter shaft. The lever also includes an atraumatic tip at a distal end thereof and adapted to contact a distal side of a native leaflet of the heart valve when the catheter shaft is positioned proximate the heart valve and the lever is in the deployed configuration, and an actuation assembly coupled to the lever to remotely transition the lever between the delivery configuration and the deployed configuration. Method for fixation of native leaflets of a heart valve using the catheter assembly also disclosed.
A dual chamber leadless pacemaker (LP) system includes a first leadless pacemaker (LP1) and a second leadless pacemaker (LP2), wherein the LP1 is configured to be implanted in or on a first cardiac chamber and to deliver pacing pulses to the first cardiac chamber, and the LP2 is configured to be implanted in or on a second cardiac chamber and to deliver pacing pulses to the second cardiac chamber. Information is obtained about a magnitude of the pacing pulses that the LP2 is configured to deliver to the second cardiac chamber and/or a sensitivity of a sense circuit of the LP1 that is configured to be used by the LP1 to detect intrinsic depolarizations of the first cardiac chamber. A crosstalk protection duration is determined based on at least some of the information so that when crosstalk protection is perform, it is performed for an appropriate duration.
A61N 1/375 - Constructional arrangements, e.g. casings
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
29.
IMPLANTABLE MEDICAL DEVICES, SYSTEMS AND METHODS FOR REDUCING T-WAVE OVERSENSING AND ARRHYTHMIA UNDERSENSING
Described herein are implantable medical devices and systems, and methods for use therewith, for reducing T-wave oversensing and arrythmia undersensing that occur due to inappropriate filtering of a signal indicative of cardiac electrical activity. A method includes obtaining a signal indicative of cardiac electrical activity, and using a first bandpass filter to produce a first filtered version thereof, using a second bandpass filter to produce a second filtered version thereof, wherein the first bandpass filter passes frequencies within a first frequency range, and the second bandpass filter passes frequencies within a second frequency range that is wider than the first frequency range. The method also includes selectively changing from using the first filtered version of the signal to monitor for a VS event, to using the second filtered version of the signal to monitor for a VS event, based on first criteria, and vice versa, based on second criteria.
The present disclosure relates to compositions for use in the isothermal amplification of nucleic acids in a sample. In particular, the present disclosure provides compositions that include one or more monosaccharides and/or one or more disaccharides and methods for amplifying at least one target nucleic acid in a sample using the disclosed compositions. The present disclosure further provides systems and kits for performing such methods and using such compositions.
An implantable continuous analyte monitor may include a printed circuit board (PCB), one or more sensor electronics, an analyte sensor, a rechargeable battery connected to the PCB and configured to supply power to the sensor electronic(s), a receiver induction coil configured to produce an induced current for charging the rechargeable battery in a wireless and transcutaneous manner, and a polymer encapsulation medium that encapsulates the PCB, the sensor electronic(s), the rechargeable battery, and the receiver induction coil. At least part of the analyte sensor remains unencapsulated by the polymer encapsulation medium to expose the analyte sensor to interstitial fluid when the implantable continuous analyte monitor is subcutaneously implanted in a subject.
A continuous analyte monitoring system, includes a continuous analyte monitor, the continuous analyte monitor configured to generate analyte data based on the patient's measured analyte levels, the continuous analyte monitor having a transmitter configured to transmit the analyte data. In some embodiments, the continuous analyte monitoring system is a continuous lactate monitoring system. The system also includes an external transmitter that is configured to receive the lactate data from the transmitter and a computing device connected to the continuous analyte monitor through the external transmitter. The continuous analyte monitoring system is implemented within a distributed diagnostic system that generates customized visual elements for alerts and notifications that are communicated to multiple distributed downstream recipient devices.
According to one aspect of the disclosure, a collapsible and expandable medical device for occluding a left atrial appendage ("LAA"), includes a proximal disc, a distal lobe, and a connecting member. The proximal disc may be configured to cover an ostium of the LAA in an implanted condition of the medical device. The distal lobe may be configured to be received within a cavity of the LAA in the implanted condition of the medical device. The distal lobe may include a central longitudinal axis extending therethrough in an expanded condition of the medical device. The connecting member may connect the proximal disc to the distal lobe. In the expanded condition of the medical device, the proximal disc may not be radially symmetric about the central longitudinal axis of the distal lobe.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
34.
METHODS AND SYSTEMS FOR CONTINUOUS ANALYTE MONITORING
A continuous analyte monitoring system, includes a continuous analyte monitor, the continuous analyte monitor configured to generate analyte data based on the patient's measured analyte levels, the continuous analyte monitor having a transmitter configured to transmit the analyte data. In some embodiments, the continuous analyte monitoring system is a continuous lactate monitoring system. The system also includes an external transmitter that is configured to receive the lactate data from the transmitter and a computing device connected to the continuous analyte monitor through the external transmitter. The continuous analyte monitoring system is implemented within a distributed diagnostic system that generates customized visual elements for alerts and notifications that are communicated to multiple distributed downstream recipient devices.
An extraction tool includes a handle and a tray that extends from the handle. The tray is configured to be advanced into a subcutaneous region of a patient. The tray includes a platform and a raised rim that projects above a top surface of the platform. The top surface of the platform and the raised rim define a cavity configured to receive and contain a subcutaneous implantable medical device (S-IMD) therein. The handle is configured to be manipulated by an operator to withdraw the extraction tool from the patient with the S-IMD on the tray.
A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A biostimulator and a biostimulator system for septal pacing, is described. The biostimulator includes a burrowing nose to allow the biostimulator to embed within a target tissue. The embedded biostimulator has a reduced exposed length within a heart chamber, and is less likely to interfere with adjacent heart structures. Embodiments include burrowing ridges on a nose or a housing of the biostimulator to affix the embedded biostimulator to the target tissue. Other embodiments are also described and claimed.
A prosthetic heart valve may include a collapsible and expandable stent extending in a flow direction between a proximal end and a distal end, a cuff attached to an annulus section of the stent and having an outer surface facing in a radial direction orthogonal to the flow direction, a plurality of prosthetic valve leaflets attached to the cuff, and a sealing structure attached to the annulus section of the stent at an inner edge of the sealing structure. The flow direction may be defined from the proximal end toward the distal end. The sealing structure may have an outer edge remote from the inner edge. The sealing structure may have a collapsed condition with the outer edge disposed adjacent the outer surface of the cuff and an expanded condition with the outer edge spaced apart from the outer surface of the cuff.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical preparations, medicines for human purposes;
sanitary preparations for medical use; dietetic food and
substances adapted for medical use, nutraceutical
preparations for therapeutic or medical use; dietary
supplements; vitamin preparations; plasters, materials for
dressings.
43.
DEVICES, SYSTEMS AND METHODS FOR ON-SKIN OR ON-BODY MOUNTING OF MEDICAL DEVICES
Devices, systems, methods and kits for releasably mounting a medical device on the body or skin of a user are provided. Embodiments include a holder or mounting unit or structure that retains a medical device in a fixed position on a body part of a user or host, such as on the surface of the skin, and/or provides physical and/or electrical coupling to one or more additional components which may be operatively positioned above and/or below the surface of the skin.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
44.
SYSTEMS AND METHODS FOR BURST WAVEFORMS WITH ANODIC-LEADING PULSES
The present disclosure provides systems and methods for generating burst waveforms. An implantable neurostimulation system includes an implantable stimulation lead including a plurality of contacts, and an implantable pulse generator communicatively coupled to the stimulation lead. The pulse generator is configured to generate a waveform including a burst that includes a leading anodic pulse followed by alternating cathodic pulses and anodic pulses, each cathodic pulse in the burst having a greater amplitude than the previous cathodic pulse.
The systems and methods described herein generally relate to adjusting a neurostimulation (NS) therapy based on drug pharmacokinetics of a patient. The systems and methods deliver an NS therapy to a portion of electrodes of a lead positioned proximate to neural tissue of interest, which is associated with a target region. The NS therapy is defined by stimulation parameters. The systems and methods determine a trigger event indicative of a drug being administered to a patient. The drug is configured to affect at least one of the neural tissue of interest or the target region. The systems and methods adjust one or more of the stimulation parameters based on the PS profile.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
46.
IMPLANTABLE LEADLESS BIOSTIMULATORS AND METHODS FOR USE THEREWITH
Implantable leadless biostimulators and related methods are described. The implantable leadless biostimulator comprises first, second and third electrodes, and also includes circuitry configured to cause a first set of the electrodes, which includes the first electrode and the third electrode, but does not include the second electrode, to be used during first periods of time to deliver stimulation pulses to the patient tissue. The circuitry is also configured to cause a second set of the electrodes, which includes the second electrode and the third electrode, to be used during second periods of time to at least one of transmit conductive communication pulses to, or receive conductive communication pulses from, one or more other devices. The second set of electrodes optionally includes the first electrode electrically connected to the second electrode.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A61N 1/375 - Constructional arrangements, e.g. casings
A biostimulator system includes a biostimulator coupled to a biostimulator transport system. The biostimulator includes a header assembly. The header assembly includes a flange having a central axis. A fixation element mount is mounted on the flange. The fixation element mount includes a mounting ring on an insulator base. The mounting ring extends around the central axis within a groove of the insulator base. A fixation element is coupled to the mounting ring. Other embodiments are also described and claimed.
A flexible electrode includes a flexible, electrically insulative substrate, a bonding layer disposed on a first surface of the substrate, a conductive layer disposed on a second surface of the substrate, and a via through the bonding layer and the substrate that exposes a portion of the reverse surface of the conductive layer. The exposed portion of the reverse surface can be secured (e.g., soldered) to a conductive contact, such as a conductive pill, on an exterior surface of a catheter shaft. The flexible electrode can then be wrapped around the exterior surface of the shaft to form a ring electrode and the bonding layer can be bonded to the catheter shaft, such as by reflow bonding.
The present disclosure provides an electrophysiology system to facilitate visualizing a proximity of at least one catheter electrode to a 3D geometry of a biological tissue. The system includes a computing device including at least one processor in communication with a memory, wherein the processor is configured to determine the proximity between the at least one catheter electrode and the biological tissue using at least one measurement. The system further includes a display device configured to display the 3D geometry of the biological tissue and a visual effect illustrating the proximity between the at least one catheter electrode and the biological tissue.
Electrophysiological activity can be mapped using an electroanatomical mapping system. Using electrophysiological data from a clique of at least four non-coplanar electrodes, the mapping system derives a three-dimensional vectorcardiogram for the clique; analyzes a shape of the vectorcardiogram; identifies first and second omnipolar electrograms for the clique; defines an activation direction for the clique; and computes a conduction velocity magnitude for the clique, thereby determining a cardiac activation vector at the cardiac location. The cardiac location can be classified as pathological when the orientations of the first and second omnipolar electrograms differ by more than a threshold amount and/or when the shape of the three-dimensional vectorcardiogram satisfies at least one of a non-planarity criterion and a directional criterion. Various graphical representations of the foregoing analyses are contemplated.
The present disclosure provides an analyte sensor for use in detecting aspartate and/or asparagine. In certain embodiments, an aspartate-responsive active site of a presently disclosed analyte sensor includes an aspartate oxidase disposed upon a surface of a working electrode. In certain embodiments, an asparagine-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising an aspartate oxidase and an asparaginase disposed upon a surface of a working electrode. The present disclosure further provides methods for detecting aspartate and/or asparagine using the disclosed analyte sensors.
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
A capacitor is provided that includes a capacitor stack including an anode layer, cathode layer, and electrolytic layer electrically coupled together, the capacitor stack including a capacitor stack periphery. The capacitor also includes a first cover portion having a first cover portion periphery that aligns with the capacitor stack periphery, and a second cover portion having a second cover portion periphery that aligns with the capacitor stack periphery and received the first cover portion periphery to form a shell body for encasing the capacitor stack therein. The capacitor stack is isolated from the second cover portion to provide a neutrally charged second cover portion that is electrically coupled within an implanted medical device.
According to one aspect of the disclosure, a collapsible and expandable medical device for occluding a left atrial appendage (“LAA”), includes a proximal disc, a distal lobe, and a connecting member. The proximal disc may be configured to cover an ostium of the LAA in an implanted condition of the medical device. The distal lobe may be configured to be received within a cavity of the LAA in the implanted condition of the medical device. The distal lobe may include a central longitudinal axis extending therethrough in an expanded condition of the medical device. The connecting member may connect the proximal disc to the distal lobe. In the expanded condition of the medical device, the proximal disc may not be radially symmetric about the central longitudinal axis of the distal lobe.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
An implantable lead includes a lead body extending along a central axis from a proximal lead portion to a distal lead portion. The lead body includes a central lumen in the distal lead portion. The implantable lead includes a drive coupling rotatably mounted in the central lumen. The drive coupling includes a screw drive. The implantable lead includes a helical fixation element mounted on the drive coupling. Other embodiments are also described and claimed.
A collapsible and expandable medical device may include a proximal end disc having a diameter that is greater than a distal lobe of the medical device. The distal lobe may have an axial length. The proximal disc may be connected to the distal lobe by a connecting member. A stabilizing wire may be coupled to the distal lobe, and may have a backing portion, and first and second legs terminating in first and second hooks, respectively, that are configured to engage tissue at a target implant site. The stabilizing wire may have an axial length measured from a proximal-most end of the backing portion to a distal-most end of the first and second hooks when the medical device is in the expanded condition, the axial length of the stabilizing wire being between about one quarter and about one half of the axial length of the lobe.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
56.
Display screen or portion thereof with transitional graphical user interface
An assembly for insertion of an analyte sensor is provided. The assembly can include an applicator having an applicator housing, a sharp, a carrier configured to releasably retain a sensor control device, and an applicator cap removably coupled with the applicator housing. The assembly can further include a sensor control device configured to be worn on skin of a user, which includes a sensor control device housing, sensor electronics disposed in the sensor control device housing, the analyte sensor, a sensor cap, a collar configured to snap-fit into the sensor cap, an adhesive patch comprising a distally-facing surface configured to adhere to the skin of the user, and an adhesive liner. The adhesive liner can be configured such that removal of the applicator cap and/or the sensor cap causes removal of the adhesive liner from the adhesive patch.
Dose guidance systems and methods for titrating medication doses are described. The dose guidance system may receive glucose data from a continuous glucose monitor and may receive medication data related to medication administered by the user. The dose guidance system may initialize dose guidance parameters, recommend medication doses, titrate medication doses, and provide alerts based on the glucose data and medication data.
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
59.
BIOSTIMULATOR TRANSPORT SYSTEM HAVING RELEASE MECHANISM
A biostimulator transport system includes a locking tube having a central lumen. The biostimulator transport system includes a tether extending through the central lumen. The tether includes a locking end coupled to a tether body. The locking end is wider than the tether body. Other embodiments are also described and claimed.
A biostimulator, such as a leadless cardiac pacemaker, having a header assembly that includes an antenna, is described. The antenna can be integrated into an insulator that separates an electrode of the header assembly from a flange of the header assembly. The antenna includes an antenna loop embedded in a ceramic material of the insulator. The antenna loop is located distal to the flange to reduce the likelihood of signal interference and increase communication range of the antenna. The header assembly is mounted on a housing have an electronics compartment, and an antenna lead extends from the antenna loop to electronic circuitry contained within the electronics compartment. Other embodiments are also described and claimed.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
A61N 1/375 - Constructional arrangements, e.g. casings
H01Q 1/40 - Radiating elements coated with, or embedded in, protective material
H01Q 7/00 - Loop antennas with a substantially uniform current distribution around the loop and having a directional radiation pattern in a plane perpendicular to the plane of the loop
A biostimulator and a biostimulator system for septal pacing, is described. The biostimulator includes an articulation to allow an electrode axis of a pacing electrode to be directed differently than a housing axis of a housing. The housing contains electrical circuitry that is electrically connected to the pacing electrode. The differently directed axes allow the pacing electrode to affix to target tissue of an interventricular septal wall of a heart when the housing of the biostimulator is located near an apex of the heart. The articulation can include a flexible portion of an extension, a hinge, or a tether. Other embodiments are also described and claimed.
Described is a steerable catheter assembly including an elongated catheter shaft with a steerable section that can be articulated to navigate the catheter shaft through a tortuous path through a patient's vasculature. The steerable section includes a planarity member(s) disposed within and fixedly attached (e.g., row of holes extending along a length of the planarity member). The planarity member extend along the centerline of the steerable section. The planarity member has a cross-sectional area perpendicular to the centerline. The cross-sectional area has a maximum principal area moment of inertia of at least 5 times a minimum principal area moment of inertia. The catheter shaft also includes a deflection lumen offset from the planarity member, and a pull wire disposed within the deflection lumen and operable to induce deflection of the elongated catheter shaft section.
A method of displaying a position of a variable loop catheter that includes a distal feature having a plurality of electrodes located along a length of the distal feature. Raw impedance-based positions of each of the plurality of electrodes located at a distal end of the variable loop catheter are calculated based on voltages sensed by each of the plurality of electrodes. The method includes determining whether a loop is formed by the distal feature based on the raw impedance-based positions of each of the plurality of electrodes. A radius of the loop formed by the distal feature is calculated based on a detected overlap between respective electrodes. The measured raw impedance-based positions of each of the plurality of electrodes is corrected based on the calculated radius of the loop.
Embodiments are disclosed of a loading tool for a biostimulator transport system. The loading tool includes a plunger having a free end and a tether end. A tether is coupled to the tether end of the plunger and coupled to a biostimulator. The plunger is stored in a storage container and can exit the storage container through an outlet.
A collapsible and expandable medical device may include a proximal end disc having a diameter that is greater than a distal lobe of the medical device. The distal lobe may have an axial length. The proximal disc may be connected to the distal lobe by a connecting member. A stabilizing wire may be coupled to the distal lobe, and may have a backing portion, and first and second legs terminating in first and second hooks, respectively, that are configured to engage tissue at a target implant site. The stabilizing wire may have an axial length measured from a proximal-most end of the backing portion to a distal-most end of the first and second hooks when the medical device is in the expanded condition, the axial length of the stabilizing wire being between about one quarter and about one half of the axial length of the lobe.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
66.
SYSTEM AND METHOD FOR ELECTROPHYSIOLOGICAL MAPPING
Electrophysiological activity can be mapped using an electroanatomical mapping system. Using electrophysiological data from a clique of at least four non-coplanar electrodes, the mapping system derives a three-dimensional vectorcardiogram for the clique; analyzes a shape of the vectorcardiogram; identifies first and second omnipolar electrograms for the clique; defines an activation direction for the clique; and computes a conduction velocity magnitude for the clique, thereby determining a cardiac activation vector at the cardiac location. The cardiac location can be classified as pathological when the orientations of the first and second omnipolar electrograms differ by more than a threshold amount and/or when the shape of the three-dimensional vectorcardiogram satisfies at least one of a non-planarity criterion and a directional criterion. Various graphical representations of the foregoing analyses are contemplated.
Aspects of the present disclosure are directed to flexible catheters for both electrophysiology mapping and ablation using a high-density array of electrodes. These catheters may be used to detect electrophysiological characteristics of tissue in contact with the electrodes, and conduct monopolar and bipolar ablations of the tissue.
Embodiments of the present invention provide an improved vascular occlusion device for occlusion of a passageway, cavity, or the like. According to one embodiment, a medical device for occluding a left atrial appendage is provided. The medical device includes a first portion having at least one plane of occlusion that is configured to be positioned outside of the left atrial appendage, and a second portion having at least one plane of occlusion that is configured to be at least partially positioned within a cavity defined by the left atrial appendage.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
A catheter is disclosed comprising a catheter shaft including a proximal end and a distal end. A flexible framework can be connected to the distal end of the catheter shaft, wherein the flexible framework includes a plurality of heating electrodes and a temperature sensor. The plurality of heating electrodes can be configured to be heated to a first temperature, the first temperature being lower than which radio frequency ablation is performed. The plurality of heating electrodes can be configured to be heated to a second temperature, the second temperature being a temperature at which radio frequency ablation is performed.
Provided herein are improved assays, methods, and systems for determining the amount, concentration, or level of cardiac myosin binding protein C ("cMyC") in a biological sample obtained from a subject. The improved assays, methods, and systems can generate a result (e.g., the amount or level of cMyC) in less than about 1 hour and are highly specific and sensitive.
An assembly for insertion of an analyte sensor is provided. The assembly can include an applicator having an applicator housing, a sharp, a carrier configured to releasably retain a sensor control device, and an applicator cap removably coupled with the applicator housing. The assembly can further include a sensor control device configured to be worn on skin of a user, which includes a sensor control device housing, sensor electronics disposed in the sensor control device housing, the analyte sensor, a sensor cap, a collar configured to snap-fit into the sensor cap, an adhesive patch comprising a distally-facing surface configured to adhere to the skin of the user, and an adhesive liner. The adhesive liner can be configured such that removal of the applicator cap and/or the sensor cap causes removal of the adhesive liner from the adhesive patch.
An analyte monitoring system including an analyte monitoring device and an overbandage assembly. The analyte monitoring device includes a housing, an analyte sensor, sensor electronics coupled to the analyte sensor, and an adhesive pad for securing the housing to a skin surface of a user. The overbandage assembly is configured to help to secure the analyte monitoring device to the skin surface. The overbandage assembly includes a backing layer, an adhesive layer, and one or more liners.
A torque device for torquing and advancing a guidewire into a patient's vascular system. The torque device is configured for single-handed use and can be used for gripping the guidewire to provide axial and rotational movement to the guidewire.
St. Jude Medical, Atrial Fibrillation Division, Inc. (USA)
Inventor
Paul, Saurav
Tegg, Troy T.
Byrd, Israel A.
Thao, Riki
Puryear, Harry A.
Nemec, Linda
Abstract
Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
A method of displaying a position of a variable loop catheter that includes a distal feature having a plurality of electrodes located along a length of the distal feature. Raw impedance-based positions of each of the plurality of electrodes located at a distal end of the variable loop catheter are calculated based on voltages sensed by each of the plurality of electrodes. The method includes determining whether a loop is formed by the distal feature based on the raw impedance-based positions of each of the plurality of electrodes. A radius of the loop formed by the distal feature is calculated based on a detected overlap between respective electrodes. The measured raw impedance-based positions of each of the plurality of electrodes is corrected based on the calculated radius of the loop.
Analyte monitoring systems, devices, and methods associated with analyte monitoring devices, and devices incorporating the same are provided. Various graphical user interfaces (GUI) and navigation flows are provided for performing various features, activities, functions, etc., associated with the analyte monitoring device or system. Intuitive navigation is provided to enhance the interpretation of analyte measurements.
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G01N 33/487 - Physical analysis of biological material of liquid biological material
A method of manufacturing an electrolytic capacitor includes impregnating an electrolytic capacitor with a first electrolyte to form a first impregnated capacitor, aging the first impregnated capacitor using a first aging process to form a first aged capacitor, impregnating the first aged capacitor with a second electrolyte to form a second impregnated capacitor, and aging the second impregnated capacitor using a final aging process to form a final aged capacitor.
Embodiments of the present invention provide an improved vascular occlusion device for occlusion of a passageway, cavity, or the like. According to one embodiment, a medical device for occluding a left atrial appendage is provided. The medical device includes a first portion having at least one plane of occlusion that is configured to be positioned outside of the left atrial appendage, and a second portion having at least one plane of occlusion that is configured to be at least partially positioned within a cavity defined by the left atrial appendage.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
79.
ELECTROLYTIC CAPACITOR AND METHOD FOR FORMING THE SAME
A method for manufacturing an electrolytic capacitor for an implantable medical device is provided. The method can include placing a metal foil within an etch solution and etching tunnels in the metal foil during an electrochemical reaction. In addition, the method may include vibrating the metal foil while the metal foil is within the etch solution.
Systems and methods which provide for and enable sensing responsive signals with respect to the application of paresthesia-free stimulation are described. Sensing signal initiators may be utilized comprising one or more non-therapeutic and/or non-tonic pulses in the form of pinging-pulses configured for invoking responsive signals suitable for measurement and/or analysis in association with the application of neural stimuli. A sensing signal initiator technique may provide an interleaved implementation to introduce one or more pinging-pulses between burst groups of a burst stimulation regimen. Additionally or alternatively, a sensing signal initiator technique may provide a postfixed implementation to introduce one or more pinging-pulses by modifying a therapeutic stimulation burst so that the last phase of the passive discharge is replaced with pinging-pulse providing an active discharge.
Aspects of the present disclosure provide an analysis cartridge that allows analyzing cellular components of a fluid sample, such as a blood sample. In certain embodiments, the analysis cartridge comprises a complete blood count (CBC) module for analyzing cells. The CBC module comprises an imaging chamber comprising a top panel and a bottom panel separated by a suitable distance to produce a monolayer of cells between the panels. The CBC module also comprises a mechanism to deliver into the imaging chamber a small volume of fluid, for example, between 0.1 to 2 µl of fluid. Also provided are methods of analyzing fluid samples in the analysis cartridges provided herein.
A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
G06F 9/06 - Arrangements for program control, e.g. control units using stored programs, i.e. using an internal store of processing equipment to receive or retain programs
G06F 15/00 - Digital computers in generalData processing equipment in general
84.
SYSTEM AND METHOD FOR OPERATING AN IMPLANTABLE PULSE GENERATOR FOR NEUROMODULATION
A system and method for operating an implanted medical device (IMD) based on a waveform player. In one arrangement, the IMD may comprise a first module operative to effectuate a communication interface with an external device for receiving a plurality of program records for storage in a persistent memory, the program records each comprising a plurality of pulse definitions and a plurality of time interval definitions, wherein a pulse definition comprises a set of pulse characteristics to be applied in a particular time interval. A second module may be communicatively coupled to the first module, the second module including a buffer for containing a runtime image of a selected program record loaded from the persistent memory. A waveform player provided as part of the second module is operative to interpret the runtime image to generate control signals to drive an output driver circuit for applying pulse characteristics to a select set of electrodes according to the pulse definitions of the selected program record.
An introducer sheath for implanting a subcutaneous lead into a patient includes a gripping element and a tubular body. The gripping element is configured to be held by an operator. The tubular body extends a length from the gripping element to a distal end of the introducer sheath. The tubular body defines an internal cavity that extends the length of the tubular body. The internal cavity is sized and shaped to accommodate a rod of a tunneling tool therethrough. The tubular body defines an array of flushing holes at different locations along the length of the tubular body and at different radial locations along a perimeter of the tubular body.
Disclosed embodiments include methods and systems including a receiver unit of a glucose monitoring system. The receiver unit is configured to receive a key associated with a transmitter unit that enables the receiver unit to identify the transmitter unit, initiate communication with the transmitter unit, access a communication key uniquely associated with the transmitter unit, and receive communication packets from the remote transmitter unit on a periodic basis including data indicative of a glucose level of a bodily fluid. The receiver unit is further configured to process the data determine the glucose level for display, output a numerical representation of the determined glucose level in a GUI, and transmit data indicative of the glucose level to a second receiver unit.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/1468 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means
A61B 5/1473 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
A61B 5/1486 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
88.
SYSTEMS AND METHODS FOR PROVIDING DIGITAL HEALTH SERVICES
The present disclosure is directed to providing digital health services. In some embodiments, systems and methods for conducting virtual or remote sessions between patients and clinicians are disclosed. During the sessions, media content (e.g., images, video content, audio content, etc.) may be captured as the patient performs one or more tasks. The media content may be presented to the clinician and used to evaluate a condition of the patient or a state of the condition, adjust treatment parameters, provide therapy, or other operations to treat the patient. The analysis of the media content may be aided by one or more machine learning/artificial intelligence models that analyze various aspects of the media content, augment the media content, or other functionality to aid in the treatment of the patient.
G06T 19/00 - Manipulating 3D models or images for computer graphics
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
G06V 40/20 - Movements or behaviour, e.g. gesture recognition
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
H04N 5/272 - Means for inserting a foreground image in a background image, i.e. inlay, outlay
A tethering apparatus is described. The tethering apparatus includes a support wire and a distal anchor coupled to the support wire. The distal anchor includes a tether attachment adapted to secure a first end of a tether. A proximal anchor is coupled to the support wire proximal to the distal anchor. A tethering mechanism is coupled to the proximal anchor and adapted to receive a second end of a tether. The tethering mechanism is movable between a closed position that retains the second end of the tether and an open position that releases the second end of the tether.
A61N 1/372 - Arrangements in connection with the implantation of stimulators
90.
METHODS AND SYSTEMS FOR MANAGING OUTCOMES FOR WEIGHT-LOSS GLP-1 RECEPTOR AGONIST THERAPIES USING BIOCHEMICAL DATA-TRAINED MODELS AND/OR OTHER PATIENT CENTRIC ANALYSIS
Embodiments disclosed herein include methods and systems for managing outcomes for weight-loss GLP-1 receptor agonist therapies using biochemical data-trained models and/or other patient centric analysis. In some embodiments, one or more biomarkers or other patient data are employed for training AI/ML or other computational models and/or as inputs to AI/ML or other computational models to evaluate patient response to GLP-1 receptor agonist therapy. For example, the computational models may be configured to perform classifications with respect to success of GLP-1 receptor agonist therapy and/or adverse effects during GLP-1 receptor agonist therapy.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
91.
METHODS FOR IMPROVING BONE HEALTH WITH BOVINE MILK EXOSOME-ENRICHED PRODUCTS AND VITAMIN K2
A method for improving bone formation in an individual comprises administering a bovine milk exosome-enriched product and vitamin K2 to the individual. A method for reducing a risk of bone fracture or strengthening bone in an individual comprises administering a bovine milk exosome-enriched product and vitamin K2 to the individual. A method for preventing or delaying onset or development of osteoporosis in an individual comprises administering a bovine milk exosome-enriched product and vitamin K2 to the individual.
An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices. Embodiments include removing a substantially cylindrical cap from an inserter to expose a substantially cylindrical sleeve, removing a cover from a substantially cylindrical container holding sensor components, and fitting the sensor components into the inserter.
Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor, such as a dermal sensor, for sensing an analyte level in a bodily fluid of a subject. An applicator is positioned against a skin surface and a force is applied to the applicator causing at least a portion of a sharp and an in vivo analyte sensor to be positioned in the body of the subject. In particular, disclosed herein are embodiments of applicators designed to prevent premature sharp withdrawal and/or reduce the likelihood of improper sensor insertion. Also disclosed are embodiments of applicators including sharp modules having an angled sharp which can be configured to create an insertion path for a sensor.
St. Jude Medical, Atrial Fibrillation Division, Inc. (USA)
Inventor
Eliason, Braden J.
Deno, D. Curtis
Voth, Eric J.
Just, Dale E.
Abstract
An electrophysiology catheter is provided. In one embodiment, the catheter includes an elongate, deformable shaft including a proximal end and a distal end and a basket electrode assembly coupled to the distal end of the shaft. The basket electrode assembly configured to assume a compressed state and an expanded state. The electrode assembly further includes an inner structure including an inner electrode disposed thereon and an outer structure including a plurality of outer electrodes disposed thereon. The inner electrode is positioned within an envelope defined by the outer structure when the basket electrode assembly is in the expanded state.
A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
A61B 5/027 - Measuring blood flow using electromagnetic means, e.g. electromagnetic flow meter using catheters
A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
A61B 5/287 - Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
In some examples, a delivery device includes a handle having an immovable portion, a sheath defining a lumen and extending distally from the handle, the sheath having a deflectable proximal curve and a deflectable distal curve spaced from the deflectable proximal curve, at least one pull ring formed within the sheath, one or more pull wires coupled to the at least one pull ring, and a first deflection knob for actuating the sheath at the deflectable proximal curve, the first deflection knob being disposed adjacent the immovable portion, and a second deflection knob for actuating the sheath at the deflectable distal curve, the second deflection knob being disposed adjacent the first deflection knob, wherein the combined length of the immovable portion, the first deflection knob and the second deflection knob is less than 6 inches.
A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
A61B 17/00 - Surgical instruments, devices or methods
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
96.
IMPLANTABLE MEDICAL DEVICE DELIVERY SYSTEM AND METHOD
A delivery system and method are described that include a catheter and an active wire. The catheter has a catheter body that defines a primary lumen and a secondary lumen therethrough, which are spaced apart from each other. A distal end of the catheter body is configured to be located within a chamber of a heart proximate to myocardial tissue at a site of interest (SOI). The primary lumen has a greater cross-sectional size than the secondary lumen. The primary lumen is configured to receive at least a portion of an IMD therein and to permit the portion of the IMD to move relative to the catheter. The active wire is configured to extend through the secondary lumen so that a distal end of the active wire projects beyond the distal end of the catheter body to pierce the myocardial tissue at the SOI.
Delivery device includes a handle (handles 100D,100E,100F) having an immovable portion (503F), a sheath (600) defining a lumen and extending distally from the handle, the sheath having a deflectable proximal curve and a deflectable distal curve spaced from the deflectable proximal curve, at least one pull ring formed within the sheath, one or more pull wires coupled to the at least one pull ring, and a first deflection knob (500A) for actuating the sheath at the deflectable proximal curve, the first deflection knob being disposed adjacent the immovable portion, and a second deflection knob (500B) for actuating the sheath at the deflectable distal curve, the second deflection knob being disposed adjacent the first deflection knob, wherein the combined length of the immovable portion, the first deflection knob and the second deflection knob is less than 6 inches.
A vessel closure device for delivering immediate hemostasis at a puncture site in a wall of a blood vessel includes an intravascular anchor having one or more suture attachment points, an extravascular cap having a lumen, a sealant, and a suture connected to at least one of the one or more suture attachment points of the intravascular anchor and threaded through the lumen of the extravascular cap, wherein each of the intravascular anchor, extravascular cap, sealant, and suture are formed of bioabsorbable materials.
