Abrégé

Provided is use of p55γ gene and/or p55γ protein as a target in maintaining cardiac iron homeostasis and treating a related disease, which belongs to the technical field of biomedicine. In the present disclosure, a p55γ transgenic mice model and an ischemia/reperfusion (I/R) injury model in vivo and in vitro are used, and it is proposed that overexpression of p55γ alleviates I/R injury induced cardiac ferroptosis, thereby protecting cardiac function. Moreover, it is found that the overexpression of p55γ leads to downregulation of transferrin receptor 1 (Tfr1) by downregulating iron-regulatory protein 2 (IRP2), thereby maintaining the cardiac iron homeostasis to resist myocardial I/R injuries. This demonstrates a potential of the p55γ gene and/or the p55γ protein as a key regulator of I/R injury induced cardiomyocyte death, thereby providing new targets for maintaining the cardiac iron homeostasis and developing novel therapeutic approaches for related diseases.

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• A61K 31/445 - Pipéridines non condensées, p. ex. pipérocaïne
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• C12N 15/86 - Vecteurs viraux
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

Provided is a use of Staphylococcus lentus with an accession number of GDMCC 1.247 in preparation of a composition for preventing and treating insulin resistance or type 2 diabetes. This strain can significantly reduce the weight gain induced by a high-fat diet (HFD), improve the glucose tolerance, promote the insulin secretion, improve the insulin resistance, and significantly improve the immunity and inflammation.

Classes IPC  ?

• A61K 35/741 - Probiotiques
• C12N 1/20 - BactériesLeurs milieux de culture
• C12R 1/44 - Staphylococcus

Abrégé

Use of a p55gamma protein or an encoding gene thereof as a target in the preparation of a drug for preventing and/or treating vascular calcification is provided, belonging to the technical field of vascular calcification prevention and treatment. The use of the p55gamma protein or the encoding gene thereof as the target in the preparation of the drug for preventing and/or treating the vascular calcification is proposed for the first time, and the p55gamma protein affects the vascular calcification by regulating phosphorylation of Yes-associated protein (YAP). It is proposed for the first time that the vascular calcification can be prevented and/or treated by overexpressing p55gamma gene or increasing the activity of the p55gamma protein.

Classes IPC  ?

• A61K 38/45 - Transférases (2)
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• C12N 15/86 - Vecteurs viraux

Abrégé

A biomarker for predicting drug resistance of a BTK inhibitor and an application thereof are provided in the present disclosure, relating to the technical field of biomedicine. The biomarker is SMPD1 or SPHK1; the drug resistance of BTK inhibitor refers to the drug resistance of diffuse large B cell lymphom cells to the BTK inhibitor. This biomarker is used to predict sensitivity of diffuse large B cell lymphom cells to the BTK inhibitors.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice

Abrégé

Disclosed are a hearing state prediction apparatus and method based on a diffusion tensor image, including: obtaining a diffusion tensor image to be processed, wherein the diffusion tensor image comprises a diffusion-weighted image; generating a diffusion index image based on the diffusion-weighted image; determining a white matter microstructural feature corresponding to the diffusion tensor image, and determining a hearing state corresponding to the diffusion tensor image according to a mapping relationship between the white matter microstructural feature and the hearing state. The apparatus may generate the diffusion index image through the diffusion-weighted image included in the diffusion tensor image, and then the white matter microstructural feature is determined based on the diffusion index image, so that the white matter microstructural feature can be identified more accurately, and the accuracy of a hearing state evaluation result is improved. Meanwhile, the relation between hearing disorder and brain microstructure change is disclosed.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61B 5/12 - Audiométrie
• G06T 7/11 - Découpage basé sur les zones
• G06T 7/50 - Récupération de la profondeur ou de la forme
• G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées

Abrégé

+Treg cells.

Classes IPC  ?

• A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 35/00 - Agents anticancéreux

Abrégé

Disclosed is use of baicalin in preparing a medicament for treating a tumor unresponsive/hyperprogressive to an immune checkpoint inhibitor, the tumor being unresponsive/hyperprogressive to the immune checkpoint inhibitor due to excessive Foxp3+Treg cells. The targeted tumor is one of melanoma, non-small cell lung cancer, renal cell carcinoma, liver cancer, colorectal cancer, urothelial bladder cancer, and pancreatic cancer, and the immune checkpoint inhibitor used comprises one of or a mixture of two or more of a PD-1 inhibitor, a PD-L1 inhibitor, and a CTLA-4 inhibitor. The synergy of the baicalin and the immune checkpoint inhibitor inhibits the number of the Foxp3+Treg cells in tumors, and exerts an anti-tumor sensitization effect, such that various bearing tumors that are unresponsive/hyperprogressive to the immune checkpoint inhibitor due to the excessive Foxp3+ Treg cells can be effectively treated; moreover, obvious adverse reactions are not observed, indicating good safety and wide application prospects.

Classes IPC  ?

• A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux

Abrégé

Provided is use of Staphylococcus lentus with an accession number of GDMCC 1.247 in preparing a composition for preventing or treating symptoms of insulin resistance or type 2 diabetes. The strain can significantly reduce the weight gain induced by a high-fat diet, improve glucose tolerance, promote insulin secretion, and improve insulin resistance, and can significantly improve immunity and ameliorate inflammation.

Classes IPC  ?

• A61K 35/74 - Bactéries
• A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
• C12N 1/20 - BactériesLeurs milieux de culture
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
• A61P 5/50 - Médicaments pour le traitement des troubles du système endocrinien des hormones pancréatiques pour augmenter ou potentialiser l'activité de l'insuline
• C12R 1/44 - Staphylococcus

Abrégé

An integrated biomarker system for evaluating a risk of impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) for the first time is disclosed. The integrated biomarker system includes quantitative determination results of L-glutamine, L-valine, L-leucine, L-lysine, L-proline, L-phenylalanine, L-arginine, L-glutamic acid, L-isoleucine, L-methionine, L-carnitine, acetyl-L-carnitine, lysophosphatidyl choline (LPC (P-16:0)), LPC (17:0), LPC (14:0) and propionyl-L-carnitine in a sample. The integrated biomarker system for IFG and T2DM of subject serum sample contains a correlative biomarker group on a biological network path to reflect the overall metabolic characteristics information of IFG and T2DM and to avoid that characteristic information of a disease cannot be reflected integrally and completely due to single or separate analysis of a biomarker.

Classes IPC  ?

• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

A method for evaluating adverse reaction of sesquiterpenoids in zedoary turmeric oil is performed successively according to the following steps: (1) preparing a hemoglobin (Hb) solution and a to-be-determined solution; (2) taking Hb solutions with a same volume and respectively adding the same volume of the to-be-determined solution or normal saline thereto, mixing well and standing; (3) determining absorbance with a microplate reader, and comparing the absorbance of a to-be-determined solution group with the absorbance of a normal saline group to obtain a value r; wherein if r>1.5, then the result indicates that the concentration of the to-be-determined solution has a risk of causing dyspnea; wherein, A method for evaluating adverse reaction of sesquiterpenoids in zedoary turmeric oil is performed successively according to the following steps: (1) preparing a hemoglobin (Hb) solution and a to-be-determined solution; (2) taking Hb solutions with a same volume and respectively adding the same volume of the to-be-determined solution or normal saline thereto, mixing well and standing; (3) determining absorbance with a microplate reader, and comparing the absorbance of a to-be-determined solution group with the absorbance of a normal saline group to obtain a value r; wherein if r>1.5, then the result indicates that the concentration of the to-be-determined solution has a risk of causing dyspnea; wherein, r = OD OD Hb ; A method for evaluating adverse reaction of sesquiterpenoids in zedoary turmeric oil is performed successively according to the following steps: (1) preparing a hemoglobin (Hb) solution and a to-be-determined solution; (2) taking Hb solutions with a same volume and respectively adding the same volume of the to-be-determined solution or normal saline thereto, mixing well and standing; (3) determining absorbance with a microplate reader, and comparing the absorbance of a to-be-determined solution group with the absorbance of a normal saline group to obtain a value r; wherein if r>1.5, then the result indicates that the concentration of the to-be-determined solution has a risk of causing dyspnea; wherein, r = OD OD Hb ; in the formula, OD is an absorbance at 280 nm wavelength of the to-be-determined solution after interacting with Hb; ODHb, is an absorbance at 280 nm wavelength of a blank control of normal saline after interacting with Hb.

Classes IPC  ?

• G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
• G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
• G01N 33/72 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les pigments du sang, p. ex. l'hémoglobine, la bilirubine

Abrégé

The present application discloses a cerebral perfusion state classification apparatus and method, a device, and a storage medium. The method includes: acquiring, by a transceiving module, cervical blood flow data from an ultrasound data collecting device; determining, by a processor, cerebral perfusion data corresponding to the cervical blood flow data based on the cervical blood flow data and a mapping relationship between the cervical blood flow data and the cerebral perfusion data, and classifying cerebral perfusion states of a plurality of brain regions based on blood perfusion characteristics of the plurality of brain regions in the cerebral perfusion data.

Classes IPC  ?

• A61B 8/08 - Applications cliniques
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/026 - Mesure du débit sanguin
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61B 8/06 - Mesure du débit sanguin
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux

Abrégé

The present disclosure discloses a cerebral perfusion state classification apparatus, method and device, and a model training apparatus. In the apparatus, a transceiver module is used for receiving physiological feature data from different data collection devices; and a processor is used for extracting physiological features from the physiological feature data; inputting the physiological features into a random forest model to cause a plurality of decision-making trees in the random forest model to predict a cerebral perfusion state type corresponding to the physiological features; and classifying a cerebral perfusion state based on the cerebral perfusion state type corresponding to the physiological features.

Classes IPC  ?

• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G06N 20/20 - Techniques d’ensemble en apprentissage automatique

Abrégé

An elastography method and apparatus, an electronic device, and a storage medium. The method comprises: applying vibrational excitation to a tissue under test and performing ultrasonic detection to obtain an ultrasonic echo signal (S101); generating an ultrasonic detection image (32) and an elasticity detection image according to the ultrasonic echo signal, wherein the elasticity detection image is used for characterizing tissue elasticity detection information and the signal quality of an ultrasonic detection signal at a corresponding moment (S102); and according to the positional relationship between a test area corresponding to the ultrasonic detection image (32) and a test area corresponding to the elasticity detection image, superimposing and displaying the ultrasonic detection image (32) and the elasticity detection image (S103). After the ultrasonic detection image (32) is generated, the elasticity detection image is superimposed and displayed on the ultrasonic detection image (32), and the imaging quality of the ultrasonic detection image (32) is characterized by the elasticity detection image, so that an operator can quickly control the quality of a detection result, eliminating the influence caused by a poor test position and respiration of a testee, etc., the ultrasonic imaging quality is improved, and the accuracy of detection results is improved.

Classes IPC  ?

• A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores

Abrégé

HbHbHb is an absorbance value at a wavelength of 280 nm after the normal saline reacts with Hb (as a blank control). The present method provides an early warning for safe medication of sesquiterpenoids in curcuma zedoaria oil.

Classes IPC  ?

• G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
• G01N 21/33 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière ultraviolette

Abrégé

Disclosed is a method for assessing the risk of impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) by means of using an integrated biomarker, which comprises obtaining the quantitative determination results of L-glutamine, L-valine, L-leucine, L-lysine, L-proline, L-phenylalanine, L-arginine, L-glutamic acid, L-isoleucine, L-methionine, L-carnitine, acetyl L-carnitine, lysophosphatidylcholine (LPC (P-16:0)), LPC (17:0), LPC (14:0) and propionyl L-carnitine in a sample. The established IFG andT2DM subject serum sample integrated biomarker comprises a biomarker group on a mutually associated bionetwork path, reflects the overall metabolic characteristic information of the IFG and the T2DM, and avoids the situation of the biomarker being analyzed singly or separately and thus lacks characteristic information for overall and comprehensive reflection of diseases.

Classes IPC  ?

• G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A stent (100) and a placement system (10). The stent (100) has a proximal end and a distal end opposite to each other, and in a direction from the distal end to the proximal end, the stent comprises a first large-diameter section (111), a first connection section (112), a middle section (120), a second connection section (131), and a second large-diameter section (132) which are connected in sequence. In the direction from the distal end to the proximal end, the outer diameter of the first connection section (112) is gradually reduced. Therefore, when the stent (100) is radially compressed to install the stent (100) into a placement device (200), along the axis of the first connection section (112), the middle section (120), the first connection section (112), and the first large-diameter section (111) are located at different axial positions, and thus, the thickness of the first connection section (112) after compression is smaller. Therefore, it is beneficial to reducing the radial pressing force between the first connection section and the displacement device (200) during installation, thereby reducing the friction force between the stent (100) and the placement device (200), and allowing stents having larger sizes to be installed without increasing the inner diameter of the placement device (200).

Classes IPC  ?

• A61F 2/82 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p. ex. stents
• A61F 2/04 - Éléments ou organes creux ou tubulaires, p. ex. vessies, trachées, bronches ou voies biliaires

Abrégé

An endoscope end cap, including a sleeve member, protrusion elements, and a movable sleeve. The sleeve member is connected to the front end of an endoscope, the sleeve member, the protrusion elements, and the movable sleeve are connected in sequence, and the movable sleeve can move freely on the outer surface of the endoscope. When the endoscope is inserted for examination, the end cap is easy to enter and does not scratch the digestive tract since the end cap has a cylinder-like structure which is smooth and has no angularity; when the endoscope is being withdrawn, the movable sleeve moves distally and abuts against the sleeve member, so as to support the protrusion elements to enable the protrusion elements to dilate the inner wall of the intestine, improving the quality of single endoscope examination, and reducing discomfort of a patient, operation risk, and operation time.

Classes IPC  ?

• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
• A61B 1/32 - Dispositifs pour ouvrir ou agrandir le champ de vision, p. ex. dans un conduit du corps
• A61B 1/31 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour le rectum, p. ex. proctoscopes, sigmoïdoscopes

Abrégé

A traction apparatus, comprising a clip portion (2) and a traction portion (1), the traction portion containing a closed traction structure (11); the closed traction structure being made from an elastic material; the clip portion comprising a main clip body (23, 25) and a clip arm (24, 26); the main clip body being capable of passing through a biopsy channel (4) of an endoscope (3), the clip arm being capable of clip the closed traction structure. Also disclosed is a traction ring used for the traction apparatus, the traction ring being a single closed traction structure or being formed by connecting several closed traction structures, the traction ring being made from an elastic material.

Classes IPC  ?

• A61B 17/02 - Instruments, dispositifs ou procédés chirurgicaux pour maintenir les blessures ouvertes, p. ex. rétracteursÉcarteurs
• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux

Abrégé

Disclosed are a key and keyway attachment denture retention structure and a production method therefore. The production method comprises: 1. collecting three-dimensional space information of a patient's teeth; 2. designing an artificial tooth crown (3) with a key retention structure; 3. integrally producing the artificial tooth crown (3) with a key retention structure; 4. designing a key-way structure (2) matched with the key retention structure; 5. producing the key-way structure (2); and 6. installing the key-way structure (2) in a base (52) of a denture (51) which needs to be fixed with the key-way structure (2). A zirconium dioxide material is integrally formed with adjacent base teeth (6), the precision is high, and the machining process is simplified. A key substrate (4) is provided to prevent the key-way structure (2) from sliding down, and to prevent the denture (51) from sinking.

Classes IPC  ?

• A61C 13/103 - Fixation des dents artificielles à un matériau de base artificiel, p. ex. à un palais artificiel ou à des dents artificielles adjacentes les dents artificielles étant fixées au matériau de base par un élément de fixation distinct, p. ex. un ergot ou une tige
• A61C 13/10 - Fixation des dents artificielles à un matériau de base artificiel, p. ex. à un palais artificiel ou à des dents artificielles adjacentes
• A61C 13/00 - Prothèses dentairesLeurs procédés de fabrication

Abrégé

A traction apparatus, comprising a clamping portion (2) and a traction portion (1), the traction portion containing a closed traction structure (11), the closed traction structure being made from an elastic material, the clamping portion comprising clamping main bodies (23, 25) and clamping arms (24, 26), the clamping main bodies being capable of passing through a biopsy channel (4) of an endoscope (3), the clamping arms being capable of clamping the closed traction structure. Also disclosed is a traction ring for the traction apparatus, the traction ring being a single closed traction structure or being formed by connecting several closed traction structures, the traction ring being made from an elastic material.

Classes IPC  ?

• A61B 17/02 - Instruments, dispositifs ou procédés chirurgicaux pour maintenir les blessures ouvertes, p. ex. rétracteursÉcarteurs

Abrégé

An endoscope end cap, comprising a sleeve member (1, 21, 31), protrusion elements (2, 22, 32), and a movable sleeve (3, 23, 33). The sleeve member (1, 21, 31) is connected to the front end of an endoscope, the sleeve member (1, 21, 31), the protrusion elements (2, 22, 32), and the movable sleeve (3, 23, 33) are connected in sequence, and the movable sleeve (3, 23, 33) can move freely on the outer surface of the endoscope. When the endoscope is inserted for examination, the end cap (101, 201, 301) is easy to enter and does not scratch the digestive tract since the end cap has a cylinder-like structure which is smooth and has no angularity; when the endoscope is being withdrawn, the movable sleeve (3, 23, 33) moves distally and abuts against the sleeve member (1, 21, 31), so as to support the protrusion elements (2, 22, 32) to enable the protrusion elements to dilate the inner wall of the intestine, improving the quality of single endoscope examination, and reducing discomfort of a patient, operation risk, and operation time.

Classes IPC  ?

• A61B 1/31 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour le rectum, p. ex. proctoscopes, sigmoïdoscopes
• A61B 1/32 - Dispositifs pour ouvrir ou agrandir le champ de vision, p. ex. dans un conduit du corps

Abrégé

This disclosure provides kits and methods for determining whether a subject is suffering from a liver disease, and/or whether the subject will be a responsive to a therapy for a liver disease. The disclosed methods comprise determining the miR profile of exosomes isolated from a body fluid of the subject.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The invention provides a method and system for health condition analysis based on an elasticity detection device. The method includes: sending, by a client, a health condition analysis request to a cloud server, where the health condition analysis request includes individual attribute identification information of a querier; acquiring, by the cloud server, to-be-analyzed data corresponding to the health condition analysis request from a cloud database storing displacement data of each querier, and conducting data analysis on the to-be-analyzed data to obtain health condition information of the querier; and receiving, by the client, the health condition information of the querier sent by the cloud server. Therefore, by virtue of mass displacement data of mass queriers stored in the cloud server, the querier can conveniently learn his/her health condition in time through the client.

Classes IPC  ?

• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
• G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• A61B 8/08 - Applications cliniques

Abrégé

This disclosure provides kits and methods for determining whether a subject is suffering from a liver disease, and/or whether the subject will be a responsive to a therapy for a liver disease. The disclosed methods comprise determining the miR profile of exosomes isolated from a body fluid of the subject.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The present invention provides a method and system for health condition analysis on the basis of an elasticity detection device. The method comprises: a client sends a health condition analysis request to a cloud server, wherein the health condition analysis request comprises individual attribute identification information of a querier; the cloud server acquires data to be analyzed corresponding to the health condition analysis request from a cloud database storing displacement data of each querier, and analyzes the data to be analyzed to obtain health condition information of the querier; and the client receives the health condition information of the querier sent by the cloud server. Therefore, by virtue of mass displacement data of mass queriers stored in the cloud server, the querier can conveniently learn the his/her health condition in time through the client.

Classes IPC  ?

• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)

Abrégé

The present disclosure discloses a cerebral perfusion state classification apparatus, method and device, and a model training apparatus. In the apparatus, a transceiver module is used for receiving physiological feature data from different data collection devices; and a processor is used for extracting physiological features from the physiological feature data; inputting the physiological features into a random forest model to cause a plurality of decision-making trees in the random forest model to predict a cerebral perfusion state type corresponding to the physiological features; and classifying a cerebral perfusion state based on the cerebral perfusion state type corresponding to the physiological features.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/026 - Mesure du débit sanguin
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• G06N 20/00 - Apprentissage automatique
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

An endoscope end cap, comprising a sleeve member (1, 21, 31), protrusion elements (2, 22, 32), and a movable sleeve (3, 23, 33). The sleeve member (1, 21, 31) is connected to the front end of an endoscope, the sleeve member (1, 21, 31), the protrusion elements (2, 22, 32), and the movable sleeve (3, 23, 33) are connected in sequence, and the movable sleeve (3, 23, 33) can move freely on the outer surface of the endoscope. When the endoscope is inserted for examination, the end cap (101, 201, 301) is easy to enter and does not scratch the digestive tract since the end cap has a cylinder-like structure which is smooth and has no angularity; when the endoscope is being withdrawn, the movable sleeve (3, 23, 33) moves distally and abuts against the sleeve member (1, 21, 31), so as to support the protrusion elements (2, 22, 32) to enable the protrusion elements to dilate the inner wall of the intestine, improving the quality of single endoscope examination, and reducing discomfort of a patient, operation risk, and operation time.

Classes IPC  ?

• A61B 1/31 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments pour le rectum, p. ex. proctoscopes, sigmoïdoscopes
• A61B 1/32 - Dispositifs pour ouvrir ou agrandir le champ de vision, p. ex. dans un conduit du corps

Abrégé

The present application discloses a cerebral perfusion state classification apparatus and method, a device, and a storage medium. The method includes: acquiring, by a transceiving module, cervical blood flow data from an ultrasound data collecting device; determining, by a processor, cerebral perfusion data corresponding to the cervical blood flow data based on the cervical blood flow data and a mapping relationship between the cervical blood flow data and the cerebral perfusion data, and classifying cerebral perfusion states of a plurality of brain regions based on blood perfusion characteristics of the plurality of brain regions in the cerebral perfusion data.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/026 - Mesure du débit sanguin
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• G06N 20/00 - Apprentissage automatique
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux