Abrégé

The present invention refers to a crystalline form of cabozantinib L-tartrate designated as Form A and a process for its preparation, a pharmaceutical composition comprising it, and its use for the the treatment of patients with progressive, metastatic medullary thyroid cancer (MTC) and for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior antiangiogenic therapy treatment of cancer.

Classes IPC  ?

• A61K 31/47 - QuinoléinesIsoquinoléines
• C07D 215/22 - Atomes d'oxygène liés en position 2 ou 4
• C07D 215/233 - Atomes d'oxygène liés en position 2 ou 4 un seul atome d'oxygène qui est lié en position 4
• A61P 35/00 - Agents anticancéreux

Produits et services

Dietetic substances suitable for medical and veterinary use; dietary supplements for humans and animals, food (nutrition) supplements; medical preparations for slimming purposes; dietary supplements for human beings and animals; extracts of medicinal plants and herbal drinks for medicinal purposes; hygiene products: pads, tampons, medical patches, dressings, paper and textile diapers for children, adults and pets; deodorants and odor neutralizing preparations, except for humans and animals; medicines for human and animal health, chemical products for medical and veterinary purposes, chemical radioactive substances for medical and veterinary purposes, cosmetics containing medicines; products for dentistry (excluding instruments/devices): dental filling materials, dental impression materials, denture and artificial tooth bonding and repair materials; substances that destroy harmful insects, harmful plants, harmful fungi and rodents; disinfectants, antiseptics (germ killers), medical detergents, medicated soaps, disinfecting soaps, antibacterial hand lotions.

Abrégé

The present invention relates to a new crystalline polymorphic form of ruxolitinib hemifumarate, namely Form III, and methods for its preparation. The new crystalline polymorph Form III of ruxolitinib hemifumarate is characterized by an XRPD pattern having characteristic peaks (2-theta ± 0.2º) at 13.7, 19.3, 21.5 and 22.7. The present invention also provides pharmaceutical compositions comprising Form III of ruxolitinib hemifumarate, and medical use of Form III.

Classes IPC  ?

• C07D 487/04 - Systèmes condensés en ortho

Produits et services

Pharmaceutical and veterinary preparations for medical purposes; chemical preparations for medical purposes; dietary supplements, including those adapted for medical purposes; nutritional supplements; dietary supplements for slimming purposes; food for babies; herbs and herbal beverages adapted for medicinal purposes; dental preparations and articles: teeth filling material, dental impression material, dental adhesives, and material for repairing teeth; sanitary preparations for medical use; hygienic pads; hygienic tampons; plasters; materials for dressings; diapers, including those made of paper and textiles; preparations for destroying vermin; fungicides, herbicides; deodorants, other than for human beings or for animals; air deodorising preparations; disinfectants; antiseptics; detergents for medical purposes.

Produits et services

Pharmaceutical and veterinary preparations for medical purposes; chemical preparations for medical and veterinary purposes, chemical reagents for pharmaceutical and veterinary purposes; dietary supplements for pharmaceutical and veterinary purposes; dietary supplements; nutritional supplements; medical preparations for slimming purposes; food for babies; herbs and herbal beverages adapted for medicinal purposes; dental preparations and articles: teeth filling material, dental impression material, dental adhesives and material for repairing teeth; sanitary preparations for medical use; hygienic pads; hygienic tampons; plasters; materials for dressings; diapers, including those made of paper and textiles; preparations for destroying vermin; fungicides, herbicides; deodorants, other than for human beings or for animals; air deodorising preparations; disinfectants; antiseptics; detergents for medical purposes.

Produits et services

Pharmaceutical and veterinary preparations for medical purposes; chemical preparations for medical and veterinary purposes, chemical reagents for pharmaceutical and veterinary purposes; medicated cosmetics; dietary supplements for pharmaceutical and veterinary purposes; dietary supplements; nutritional supplements; medical preparations for slimming purposes; food for babies; herbs and herbal beverages adapted for medicinal purposes; dental preparations and articles: teeth filling material, dental impression material, dental adhesives and material for repairing teeth; sanitary preparations for medical use; hygienic pads, hygienic tampons; plasters, materials for dressings, diapers made of paper and textiles for babies, adults and pets; preparations for destroying vermin; herbicides, fungicides, preparations for destroying rodents; deodorants, other than for human beings or for animals; air purifying preparations; air deodorising preparations; disinfectants; antiseptics; detergents for medical purposes; medicated soaps; disinfectant soaps; antibacterial hand lotions.

Abrégé

The present invention relates to a new crystalline form of vismodegib, a methanol-solvate of vismodegib, namely Form S, and methods for its preparation. The vismodegib Form S is characterized by an XRPD pattern having characteristic peaks (2theta ± 0.2º) at 7.1, 14.0, 16.7, 19.1, 22.3, 24.6 and 28.0. The present invention also provides interconversion process of vismodegib Form S to crystalline vismodegib Form B, pharmaceutical compositions comprising vismodegib Form S, and medical use of vismodegib Form S.

Classes IPC  ?

• A61P 35/00 - Agents anticancéreux
• C07D 213/40 - Atome d'azote substituant acylé

Abrégé

The present invention relates to a new crystalline polymorphic form of ruxolitinib hemifumarate hemihydrate, namely Form II, and methods for its preparation. The new crystalline polymorph Form II of ruxolitinib hemifumarate hemihydrate is characterized by an XRPD pattern having characteristic peaks (2theta ± 0.2º) at 5.4, 16.9 and 21.4. The present invention also provides pharmaceutical compositions comprising Form II of ruxolitinib hemifumarate hemihydrate, and medical use of Form II.

Classes IPC  ?

• C07D 487/04 - Systèmes condensés en ortho

Abrégé

The present invention relates to a new crystalline polymorphic Form X of vismodegib and its preparation. Preferably, the new crystalline polymorphic Form X of vismodegib is characterized by an XRPD pattern having characteristic peaks at 9.37 ± 0.2, 11.49 ± 0.2, 15.70 ± 0.2, 16.56 ± 0.2, 18.84 ± 0.2, 18.95 ± 0.2 and 23.85 ± 0.2 degree 2-theta. The present invention also provides pharmaceutical compositions comprising Form X of vismodegib, and medical use of Form X of vismodegib.

Classes IPC  ?

• C07D 213/40 - Atome d'azote substituant acylé
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to a new crystalline polymorph of benserazide hydrochloride. More specifically, the invention relates to novel Form H of benserazide hydrochloride, process for preparing the novel form of benserazide hydrochloride and pharmaceutical formulations comprising the novel form of benserazide hydrochloride.

Classes IPC  ?

• C07C 241/04 - Préparation d'hydrazides
• C07C 243/34 - Hydrazines ayant des atomes d'azote de groupes hydrazine acylés par des acides carboxyliques avec des groupes carboxyle acylants liés à des atomes d'hydrogène ou à des atomes de carbone acycliques à des atomes de carbone d'un squelette carboné substitué de plus par des atomes d'azote

Produits et services

Pharmaceutical and veterinary preparations for medical purposes; chemical preparations for medical and veterinary purposes, chemical reagents for pharmaceutical and veterinary purposes; medicated cosmetics; dietary supplements for pharmaceutical and veterinary purposes; dietary supplements; nutritional supplements; medical preparations for slimming purposes; food for babies; herbs and herbal beverages adapted for medicinal purposes; dental preparations and articles: teeth filling material, dental impression material, dental adhesives and material for repairing teeth; sanitary preparations for medical use; hygienic pads; hygienic tampons; plasters; materials for dressings; diapers made of paper and textiles for babies, adults and pets; preparations for destroying vermin; herbicides, fungicides, preparations for destroying rodents; deodorants, other than for human beings or for animals; air purifying preparations; air deodorising preparations; disinfectants; antiseptics; detergents for medical purposes; medicated soaps; disinfectant soaps; antibacterial hand lotions.

Produits et services

Pharmaceutical and veterinary preparations for medical purposes; chemical preparations and elements for medical purposes dietary supplements, including those adapted for medical purposes; dietary supplements for slimming purposes; food for babies; herbs and herbal beverages adapted for medicinal purposes; dental preparations (except tools/devices); sanitary preparations for medical use, namely hygienic pads, hygienic tampons, plasters, materials for dressings; preparations for destroying vermin; fungicides, herbicides; air deodorising preparations (other than for personal use); disinfectants; antiseptics; detergents for medical purposes.

Produits et services

Pharmaceutical and veterinary preparations for medical purposes; chemical preparations for medical and veterinary purposes, chemical reagents for pharmaceutical and veterinary purposes; medicated cosmetics; dental preparations and articles; teeth filling material, dental impression material, dental adhesives and material for repairing teeth; sanitary preparations for medical use; hygienic pads; hygienic tampons; plasters; materials for dressings; diapers made of paper and textiles for babies, adults and pets; preparations for destroying vermin; herbicides, fungicides, preparations for destroying rodents; deodorants, other than for human beings or for animals; air purifying preparations; air deodorising preparations; disinfectants; antiseptics; detergents for medical purposes; medicated soaps; disinfectant soaps; antibacterial hand lotions. Surgical, medical, dental and veterinary apparatus and instruments; furniture especially made for medical purposes; artificial limbs and prostheses; medical orthopaedic articles; corsets for medical purposes, orthopaedic shoes, elastic bandages and supportive bandages; surgical gowns and surgical sterile sheets; adult sexual aids; condoms; babies' bottles; babies' pacifiers; teats; teethers for babies; bracelets and rings for medical purposes, anti-rheumatism bracelets; anti-rheumatism rings. Office functions; secretarial services; arranging newspaper subscriptions for others; compilation of statistics; rental of office machines; systemization of information into computer databases; telephone answering for unavailable subscribers; auctioneering. Insurance services; financial and monetary affairs; real estate brokers, real estate agencies and real estate management; customs brokerage services. Scientific and industrial analysis and research services; engineering; engineering and architectural design services; testing services for the certification of quality and standards; computer services, namely, computer programming, computer virus protection services, computer system design, creating, maintaining and updating websites for others, computer software design, updating and rental of computer software, providing search engines for the Internet, hosting websites, consultancy in the design and development of computer hardware, rental of computer hardware; authenticating works of art.

Abrégé

The invention discloses novel pharmaceutically acceptable salts of eltrombopag and process for preparing the same. The invention also relates to solid state forms of eltrombopag sesquiethanolamine and processes for the preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

Classes IPC  ?

• C07D 231/10 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
• C07D 231/38 - Atomes d'azote
• C07D 231/46 - Atome d'oxygène en position 3 ou 5 et atome d'azote en position 4
• A61P 7/00 - Médicaments pour le traitement des troubles du sang ou du fluide extracellulaire
• A61P 7/06 - Antianémiques

Abrégé

The present invention relates to a new process for the preparation of a key intermediate compound and its use in a synthetic process for the preparation of pazopanib hydrochloride. The method has advantages of a simple operation, high yield and low costs. The present invention also relates to a novel polymorph of pazopanib hydrochloride.

Classes IPC  ?

• A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61P 35/00 - Agents anticancéreux
• C07D 403/02 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles
• C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons

Abrégé

The present invention relates to an efficient and industrially advantageous process for the preparation of scopine free base or salts. Said compounds are important intermediates in the synthesis of tiotropium and pharmaceutically acceptable salts thereof. The method provided for preparing scopine free base or its salts has the advantages of a simple operation, high yield and low costs.

Classes IPC  ?

• C07D 451/00 - Composés hétérocycliques contenant des systèmes cycliques aza-8 bicyclo [3.2.1] octane, aza-9 bicyclo [3.3.1] nonane ou oxa-3 aza-9 tricyclo [3.3.1.02,4] nonane, p. ex. alcaloïdes du tropane ou du granatane, scopolamineLeurs acétals cycliques
• C07D 451/10 - Atomes d'oxygène acylés par des acides carboxyliques aliphatiques ou araliphatiques, p. ex. atropine, scopolamine
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire

Produits et services

(1) Pharmaceuticals, medical and veterinary preparations, namely, for treating malignant tumors, cancer and blood disorders, urological diseases and disorders, dermatological diseases and disorders namely skin and bacterial skin infections and fungal skin infections, genitourinary system disorders namely urological diseases, sexually transmitted diseases, inflammatory pelvic diseases and sexual hormone disorders, cardiovascular diseases, musculoskeletal diseases, central and peripheral nervous system disorders, gastrointestinal diseases, metabolic diseases and disorders namely diabetes, gout, arthritis and anemia, systemic endocrine diseases namely growth and thyroid disorders, respiratory system disorders and diseases, namely asthma and COPD, ophthalmological diseases and disorders, namely glaucoma, dry eye disease, allergy, other sensory organs disorders; sanitary preparations for medical purposes, namely, medicated cleansers for skin and wounds; dietetic food and substances adapted for medical or veterinary use, namely, for the prevention and treatment of iron deficiency and anaemia in humans and in animals, food for babies; dietary supplements for human beings and animals, namely, for general health and well-being; plasters as materials for dressings; material for stopping teeth, dental wax; all-purpose disinfectants; preparations for destroying vermin; fungicides; herbicides.

Produits et services

(1) Pharmaceuticals, medical and veterinary preparations, namely, for treating malignant tumors, cancer and blood disorders, urological diseases and disorders, dermatological diseases and disorders namely skin and bacterial skin infections and fungal skin infections, genitourinary system disorders namely urological diseases, sexually transmitted diseases, inflammatory pelvic diseases and sexual hormone disorders, cardiovascular diseases, musculoskeletal diseases, central and peripheral nervous system disorders, gastrointestinal diseases, metabolic diseases and disorders namely diabetes, gout, arthritis and anemia, systemic endocrine diseases namely growth and thyroid disorders, respiratory system disorders and diseases, namely asthma and COPD, ophthalmological diseases and disorders, namely glaucoma, dry eye disease, allergy, other sensory organs disorders; sanitary preparations for medical purposes, namely, medicated cleansers for skin and wounds; dietetic food and substances adapted for medical or veterinary use, namely, for the prevention and treatment of iron deficiency and anaemia in humans and in animals, food for babies; dietary supplements for human beings and animals, namely, for general health and well-being; plasters as materials for dressings; material for stopping teeth, dental wax; all-purpose disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceuticals, medical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for human beings and animals; plasters, material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceutical preparations for use in treating by inhibiting the growth of tumors, as antiparasitics, and for treatment of the nervous systems, orthopedic and musculoskeletal disease, respiratory disease, genital and urologic disease, endocrinology disease, cardiovascular disease, dermatological disease, metabolic disease, gastrointestinal disease, hormonal diseases, ophthalmological disease, cancer and diseases of the blood, and for use in treating immune function, psychiatric disorders, fatigue, and sexual disfunction; veterinary preparations for use in treating by inhibiting the growth of tumors, as antiparasitics, and for treatment of the nervous systems, orthopedic and musculoskeletal disease, respiratory disease, genital and urologic disease, endocrinology disease, cardiovascular disease, dermatological disease, metabolic disease, gastrointestinal disease, hormonal diseases, ophthalmological disease, cancer and diseases of the blood, and for use in treating immune function, psychiatric disorders, fatigue, and sexual disfunction; sanitary preparations for medical purposes; dietetic foods, namely, food supplements and dietary supplements adapted for medical use; dietetic sugar for medical use; food for babies; dietary supplements for humans and animals; medical plasters; material for stopping teeth, dental wax; all-purpose disinfectants; preparations for destroying vermin; fungicides, herbicides

Abrégé

The present invention relates to an efficient and industrially advantageous process for the preparation of 1H-pyrazolo[3,4-d] pyrimidine derivatives. In particular the present invention provides a process for the preparation of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidine and tert-butyl (R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4- d]pyrimidin-1-yl)piperidine-1-carboxylate. Said compounds are important intermediates in the synthesis of ibrutinib. The method provided for preparing intermediates of ibrutinib has the advantages of a simple operation, high yield and low costs.

Classes IPC  ?

• C07D 471/04 - Systèmes condensés en ortho

Abrégé

The object of the present invention is to provide a pharmaceutical composition comprising solid dispersion of selinexor, having enhanced bioavailability and improved dissolution properties. In accordance with the invention, solid dispersion of selinexor is produced by hot melt extrusion method.

Classes IPC  ?

• A61P 35/00 - Agents anticancéreux
• A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
• C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 249/08 - Triazoles-1, 2, 4Triazoles-1, 2, 4 hydrogénés

Produits et services

Pharmaceuticals, medical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for human beings and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceuticals, medical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for human beings and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides; herbicides.

Produits et services

Pharmaceutical preparations for use in treating by inhibiting the growth of tumors, as antiparasitics, and for treatment of the nervous systems, orthopedic and musculoskeletal disease, respiratory disease, genital and urologic disease, endocrinology disease, cardiovascular disease, dermatological disease, metabolic disease, gastrointestinal disease, hormonal diseases, ophthalmological disease, cancer and diseases of the blood, and for use in treating immune function, psychiatric disorders, fatigue, and sexual disfunction; veterinary preparations for use in treating by inhibiting the growth of tumors, as antiparasitics, and for treatment of the nervous systems, orthopedic and musculoskeletal disease, respiratory disease, genital and urologic disease, endocrinology disease, cardiovascular disease, dermatological disease, metabolic disease, gastrointestinal disease, hormonal diseases, ophthalmological disease, cancer and diseases of the blood, and for use in treating immune function, psychiatric disorders, fatigue, and sexual disfunction; sanitary preparations for medical purposes; dietetic foods namely, food supplements and dietary supplements adapted for medical use; dietetic sugar for medical use; food for babies; dietary supplements for humans and animals; medical plasters, materials for dressings; material for stopping teeth, dental wax; all purpose disinfectants; preparations for destroying vermin; fungicides, herbicides

Produits et services

Pharmaceutical preparations for use in treating by inhibiting the growth of tumors, as antiparasitics, and for treatment of the nervous systems, orthopedic and musculoskeletal disease, respiratory disease, genital and urologic disease, endocrinology disease, cardiovascular disease, dermatological disease, metabolic disease, gastrointestinal disease, hormonal diseases, ophthalmological disease, cancer and diseases of the blood, and for use in treating immune function, psychiatric disorders, fatigue, and sexual disfunction; veterinary preparations for use in treating by inhibiting the growth of tumors, as antiparasitics, and for treatment of the nervous systems, orthopedic and musculoskeletal disease, respiratory disease, genital and urologic disease, endocrinology disease, cardiovascular disease, dermatological disease, metabolic disease, gastrointestinal disease, hormonal diseases, ophthalmological disease, cancer and diseases of the blood, and for use in treating immune function, psychiatric disorders, fatigue, and sexual disfunction; sanitary preparations for medical purposes; dietetic foods namely, food supplements and dietary supplements adapted for medical use; dietetic sugar for medical use; food for babies; dietary supplements for humans and animals; medical plasters, materials for dressings; material for stopping teeth, dental wax; all purpose disinfectants; preparations for destroying vermin; fungicides, herbicides

Abrégé

The present invention is related to a novel process for preparing compounds, which are useful intermediates to prepare Indacaterol salts. The invention process presents high yields in all steps of the synthesis. The present invention also avoids the use of the epoxide compound known in the art and the by products associated therewith. The novel process is economically favourable due to the process comprising easily accessible reagents.

Classes IPC  ?

• C07D 215/26 - AlcoolsLeurs éthers

Abrégé

New crystalline monohydrate forms of Benidipine HCl, Form C, Form D, Form E, Form F, Form G, Form H and Form I, compositions comprising these crystalline solid forms, and processes for preparing these crystalline solid forms are described herein.

Classes IPC  ?

• C07D 211/90 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène

Abrégé

The present invention relates to a stable pharmaceutical composition comprising fingolimod and calcium carboxymethylcellulose.

Classes IPC  ?

• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine

Produits et services

Dietetic food and substances adapted for medical use, food for babies, medical herbs and herbal drinks, dental products (excluding devices), sanitary preparations for personal hygiene, other than toiletries; preparations for destroying vermin; fungicides, herbicides, deodorants other than for human beings, disinfectants, antiseptics, detergents for medical purposes.

Abrégé

This invention relates to ricobendazole formulations used to control parasite species in animals and to treat the infections caused by such parasites and their methods of manufacture.

Classes IPC  ?

• A61K 9/08 - Solutions
• A61K 9/10 - DispersionsÉmulsions
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
• A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; medical dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceutical and veterinary preparations.

Produits et services

Pharmaceutical and veterinary preparations.

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Abrégé

The present invention is related to easy to use dosage forms of mozavaptan or a pharmaceutically acceptable salt thereof comprising orally disintegrating tablets, effervescent tablets, granules in sachets, dry syrup and manufacturing methods thereof.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

This invention is related to single unit formulation of fingolimod or pharmaceutically acceptable salts thereof in combination with nabiximols mostly composed of cannabidiol (CBD) type compound or derivative thereof and tetrahydrocannabinol (THC) type compound or derivative thereof in treatment of multiple sclerosis.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
• A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline

Abrégé

The present invention is related to easy to use dosage forms for low formulations of eprotirome comprising orally disintegrating tablets, effervescent tablets, granules in sachets, dry syrup and manufacturing methods thereof.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

This invention relates to an aerosol can sample content extractor apparatus for deternnining of drug content (assay) and water content or moisture content of aerosol formulation from pressurized metered dose inhalers (MDI).The device allows the accurate determination of the amount of drug inside the canister.

Classes IPC  ?

• G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
• B05B 1/00 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage
• G01N 33/15 - Préparations médicinales

Abrégé

The invention relates to single unit dosage pharmaceutical formulations comprising sevelamer or a pharmaceutically acceptable salt thereof and a fat soluble vitamin such as A, D, E, K or their analogues or mixtures thereof as well as methods of manufacturing of monolithic tablet, bilayer tablet, tablet in tablet, in lay tablet, granules in sachet, coated core tablet forms by achieving targeted content uniformity and patient compliance.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 31/593 - Dérivés du 9,10-séco-cholestane, p. ex. cholécalciférol, vitamine D3
• A61K 31/785 - Polymères contenant de l'azote
• A61K 47/02 - Composés inorganiques
• A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
• A61K 47/38 - CelluloseSes dérivés
• A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline

Abrégé

This invention is related to defining critical particle size distribution of granules and/or powder mixtures of cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate and optimizing process parameters for manufacturing.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 31/22 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine

Abrégé

This invention is directed to wet granulation methods through isopropyl alcohol, dichloromethane, methanol, acetone or mixtures thereof for manufacturing of cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 31/22 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine

Abrégé

This invention is related to pharmaceutical combination of betahistine or pharmaceutically acceptable salts thereof and trimetazidine or pharmaceutically acceptable salts thereof.

Classes IPC  ?

• A61K 31/4402 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 2, p. ex. phéniramine, bisacodyl
• A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
• A61P 27/16 - Otologiques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• A61K 9/50 - Microcapsules

Abrégé

This invention is related to a preparing method for pharmaceutical and/or dietary supplement suspension formulations of cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate.

Classes IPC  ?

• A61K 31/23 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

This invention is related to pharmaceutical or dietary supplement suspension formulations of cetylated fatty acids, especially cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate.

Classes IPC  ?

• A23L 1/30 - contenant des additifs (A23L 1/308 a priorité);;
• A61K 31/23 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

This invention is related to spray drying or melt granulation or dissolving or dispersing treatment of cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate.

Classes IPC  ?

• A23L 1/30 - contenant des additifs (A23L 1/308 a priorité);;
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 31/23 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone

Abrégé

This invention is directed to drying methods and determining of water content in granules or pharmaceutical/dietary supplement compositions or finished dosage forms of cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• A61K 31/23 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone

Abrégé

This invention is related to a preparation method of cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate by using dry granulation techniques wherein obtained granules having a bulk density equal or greater than 0.30 g/mL.

Classes IPC  ?

• A23L 1/30 - contenant des additifs (A23L 1/308 a priorité);;
• A61K 31/23 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles

Abrégé

This invention is related to bilayer tablet, inlay tablet, tablet in tablet, tablet in capsule, capsule in capsule, separated granulation and kit of combination of cetyl myristate and cetyl palmitate.

Classes IPC  ?

• A23L 1/30 - contenant des additifs (A23L 1/308 a priorité);;
• A61K 31/23 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat

Abrégé

This invention is related to using of anti-adherents in pharmaceutical or dietary supplement formulations of cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate. In this invention, cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate are used as active pharmaceutical ingredients.

Classes IPC  ?

• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 31/215 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques

Abrégé

This invention is related to coated particles of cetylated fatty acids, especially cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate by using wet granulation techniques.

Classes IPC  ?

• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 31/215 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques

Abrégé

This invention is related to using of superdisintegrants in pharmaceutical or dietary supplement formulations of cetylated fatty acids, especially cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate.

Classes IPC  ?

• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 31/215 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques

Abrégé

This invention is related to a sieving method of cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate by using screen wherein screen size is 1 mm to 1.4 mm. This invention is also directed to using of lubricants/glidants in formulations of cetyl myristate or cetyl palmitate or combination of cetyl myristate and cetyl palmitate wherein API's are sieved by screen of 1 mm to 1.4 mm.

Classes IPC  ?

• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques

Produits et services

Pharmaceutical preparations in the form of capsules (for medicine), suspensions (medicine), suppositories, syrup (for medical purposes), drops, tablets, pills (for pharmaceutical purposes).