A three-dimensional product formed by additive manufacturing, the three-dimensional product includes a plurality of continuous filaments arranged in a geometric pattern, where the plurality of continuous filaments includes a radiation-cured component and a nonradiation-cured component. A concentration of the nonradiation-cured component is in a range of greater than 5 wt % to less than 95 wt % of total weight of the three-dimensional product. The three-dimensional product includes a plurality of non-random pores located between adjacent printed continuous filaments, where an average diameter of the non-random pores is in a range of greater than 0 microns to less than 50 microns.
C09D 11/101 - Encres spécialement adaptées aux procédés d’imprimerie mettant en œuvre la réticulation par énergie ondulatoire ou par radiation de particules, p. ex. réticulation par UV qui suit l’impression
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
C08G 18/10 - Procédés mettant en œuvre un prépolymère impliquant la réaction d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs, dans une première étape réactionnelle
C08G 18/67 - Composés non saturés contenant un hydrogène actif
C09D 11/102 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
2.
PRODUCTS MADE WITH VERTICALLY ALIGNED CARBON NANOTUBES FOR MODULATING TRANSMISSION OF LIGHT
An electrochromic device, in accordance with one embodiment, includes a substrate, an optically-active working electrode having aligned carbon nanotubes (ACNTs) coupled to the substrate, a counter electrode, and an electrolyte positioned between the working electrode and the counter electrode. An electrochromic device, in accordance with another embodiment, includes a porous membrane; an optically-active working electrode coupled to a first side of the membrane, the working electrode having aligned carbon nanotubes (ACNTs), a counter electrode coupled to a second side of the membrane that is positioned on an opposite side of the membrane as the first side, and an electrolyte positioned between the working electrode and the counter electrode.
Disclosed are flow-through electrode devices and techniques for making flow-through electrodes. In one aspect, a flow through electrode apparatus comprises one or more fiber layers. Each fiber layer comprises a plurality of fibers oriented to be orthogonal to a flow direction of a fluid. The plurality of fibers are configured to cause an inertial flow of the fluid around the plurality of fibers at a first flow rate of the fluid.
G01N 23/046 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux en utilisant la tomographie, p. ex. la tomographie informatisée
H01M 4/86 - Électrodes inertes ayant une activité catalytique, p. ex. pour piles à combustible
H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires
4.
DIVERSITY USING ADVERSARIALLY LEARNED TRANSFORMATIONS FOR DOMAIN GENERALIZATION
Arizona Board of Regents on Behalf of Arizona State University (USA)
Lawrence Livermore National Security, LLC (USA)
Inventeur(s)
Gokhale, Tejas
Anirudh, Rushil
Thiagarajan, Jayaraman
Kailkhura, Bhavya
Baral, Chitta
Yang, Yezhou
Abrégé
An ALT framework (Adversarially Learned Transformations framework) may be trained to learn multiple target generalizations from a single source domain utilizing a diversity network, an adversary network, and a classifier. ALT framework may obtain an image training dataset and generate image perturbations parameterized by the adversarial network as learnable weights of a neural network representing learned image transformations by the adversarial network for the plurality of input images. Processing circuitry may train an Artificial Intelligence model (AI model) of ALT framework to learn generalizations for the single source domain from the plurality of input images of the image training dataset and the learnable weights of the neural network representing the learned image transformations by the adversarial network. Processing circuitry may train the AI model of the ALT framework to learn the multiple target generalizations from supplemental images generated by the adversarial network and output the AI model.
G06V 10/774 - Génération d'ensembles de motifs de formationTraitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source méthodes de Bootstrap, p. ex. "bagging” ou “boosting”
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
G06V 10/776 - ValidationÉvaluation des performances
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
5.
3D ELECTRODES AND FLOW STRUCTURES FOR HIGH PERFORMING HYBRID REDOX FLOW BATTERIES
A redox flow battery apparatus includes a membrane, a flow plate, and a porous electrode positioned between the membrane and the flow plate. The porous electrode has a surface configured for a reversible metal deposition thereon from a metal ion electrolyte solution flowing through the porous electrode. The porous electrode has a predefined porosity configured to allow the flowing of the metal ion electrolyte solution through the porous electrode.
H01M 4/86 - Électrodes inertes ayant une activité catalytique, p. ex. pour piles à combustible
H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires
6.
MICROGELS, LIVE CELL-LADEN MICROGELS, PRODUCTS HAVING SUCH MICROGELS, AND METHODS AND APPARATUSES FOR FABRICATING SUCH MICROGELS VIA PHOTOPOLYMERIZED IN-AIR DROP ENCAPSULATION
A live cell-laden microgel, in accordance with one aspect of the present invention, includes at least one live cell and a photocured resin. An in-air drop formed microgel, in accordance with one aspect of the present invention, includes a component selected from the group consisting of DNA, RNA, a protein, a peptide, an antibody, a living-cell produced catalyst, a nucleic acid-based material, a prokaryotic cell, an eukaryotic cell, and a different type of biological component.
A composition includes a glass-forming material and a solvent. A composition includes a glass-forming material that includes mixed composition particles and a solvent.
A product includes a three-dimensional printed structure having ligaments, where an average diameter of the ligaments is in a range of about 10 μm to about 500 μm. A method of forming a product that includes ligaments, where an average diameter of the ligaments is in a range of about 10 μm to about 500 μm, includes printing a three-dimensional structure using an ink that includes a polymer precursor, a block copolymer, a catalyst, and a solvent, immersing the printed three-dimensional structure in a second solvent for forming a gel, and drying the printed three-dimensional structure.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
C08L 53/00 - Compositions contenant des copolymères séquencés possédant au moins une séquence d'un polymère obtenu par des réactions ne faisant intervenir que des liaisons non saturées carbone-carboneCompositions contenant des dérivés de tels polymères
C08L 61/02 - Polymères de condensation obtenus uniquement à partir d'aldéhydes ou de cétones
9.
COMPOSITE MONOLITHIC TELESCOPES FOR APERTURE SCALING
Disclosed embodiments enable scaling of monolithic optical systems (e.g., monolith telescopes) up to larger aperture sizes while reducing mass scaling. An example optical system includes a monolithic mirror assembly that integrates a primary mirror and a tertiary mirror in static alignment. The optical system further includes a secondary mirror or fold mirror displaced away from the monolithic mirror assembly and having a reflective mirror surface. The secondary mirror's reflective mirror surface is positioned to direct light received from the primary mirror onto the tertiary mirror and direct light received from the tertiary mirror onto a detector. The secondary mirror is particularly configured to maintain a low alignment sensitivity, consistent with the permanent fixed alignment associated with the monolithic mirror assembly. For example, the secondary mirror has a relatively low power curvature and a weak fourth-order shape insensitive to decentering and tip/tilt misalignments when directing light onto the spherical tertiary mirror.
G02B 23/02 - Télescopes ou lunettes d'approche, p. ex. jumellesPériscopesInstruments pour voir à l'intérieur de corps creuxViseursPointage optique ou appareils de visée comprenant des prismes ou des miroirs
G02B 17/06 - Systèmes catoptriques, p. ex. systèmes redressant et renversant une image utilisant uniquement des miroirs
10.
PROCESSING METHOD TO CROSSLINK POLYELECTROLYTE MEMBRANES AT USER-SELECTED HYDRATION LEVEL FOR CONTROL OF NANOSCALE MORPHOLOGY
A method of forming a membrane includes forming a membrane structure that includes a material comprising a polymer, a crosslinking agent, and a solvent. The membrane structure is equilibrated at a selected relative humidity for a predefined duration of time for forming hydrophilic domains in the material. The hydrophilic domains have a predefined average radius. The equilibrated membrane structure is cured to crosslink the material to at least a predefined extent.
B01J 41/07 - Procédés utilisant des échangeurs organiques sous forme faiblement basique
B01J 41/13 - Composés macromoléculaires obtenus autrement que par des réactions ne faisant intervenir que des liaisons carbone-carbone non saturées
B01J 47/12 - Procédés d'échange d'ions en généralAppareillage à cet effet caractérisés par l'emploi d'une substance échangeur d'ions sous forme de rubans, de filaments, de fibres ou de feuilles, p. ex. sous forme de membranes
B33Y 80/00 - Produits obtenus par fabrication additive
C08G 65/48 - Polymères modifiés par post-traitement chimique
C25B 13/08 - DiaphragmesÉléments d'espacement caractérisés par le matériau à base de matériaux organiques
H01M 6/18 - Éléments avec électrolytes non aqueux avec électrolyte solide
H01M 8/10 - Éléments à combustible avec électrolytes solides
H01M 8/1025 - Matériaux d’électrolyte polymère caractérisés par la structure chimique de la chaîne principale du polymère conducteur ionique comprenant uniquement du carbone et de l’oxygène, p. ex. des polyéthers, des polyétheréthercétones sulfonés [S-PEEK], des polysaccharides sulfonés, des celluloses sulfonés ou des polyesters sulfonés
H01M 10/0565 - Matériaux polymères, p. ex. du type gel ou du type solide
A product, in accordance with one aspect of the present invention, includes a resin for three-dimensional printing, the resin including a photo-curable nitrile-containing photopolymer. A method for manufacturing an article of manufacture, in accordance with another aspect of the present invention, includes forming a three-dimensional (3D) structure from a photo-curable nitrile-containing photopolymer via a light-based printing process, and thermally processing the 3D structure for rendering the 3D structure electrically conductive.
C09D 133/20 - Homopolymères ou copolymères de l'acrylonitrile
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
B29C 64/30 - Opérations ou équipements auxiliaires
C08F 20/50 - Nitriles contenant au moins quatre atomes de carbone
C09D 4/00 - Compositions de revêtement, p. ex. peintures, vernis ou vernis-laques, à base de composés non macromoléculaires organiques ayant au moins une liaison non saturée carbone-carbone polymérisable
C09D 133/22 - Homopolymères ou copolymères de nitriles contenant au moins quatre atomes de carbone
Max-Planck-Gesellschaft Zur Foerderung Dur Wissenschaften E.V. (Allemagne)
The Regents of the University of California (USA)
Inventeur(s)
Noy, Alexsandr
Ho, Nga Thuy
Hummer, Gerhard
Siggel, Marc
Abrégé
Disclosed herein is an engineered lipid-based vesicle optionally used for delivery of one or more payloads. The vesicle comprises a nanotube dimer or complex embedded with a lipid bilayer of the lipid-based vesicle. Also described herein are compositions, e.g., pharmaceutical compositions, and kits comprising the engineered lipid-based vesicle. In additional embodiments, further described herein are use of the engineered lipid-based vesicle for treating a disease or condition, for delivery to a target, or for labeling of a cell.
A networking architecture that incorporates the security of Blockchain distributed ledgers as an authentication layer, while connecting mesh nodes using secure, pulse-based wide-band and ultrawide-band communication technology to provide a nearly undetectable, unbreakable, and dynamic wireless communication mesh architecture that has the ability to securely transmit data, voice and video over short ranges, in one embodiment, up to 1 Km, is disclosed.
H04L 9/00 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
C07D 409/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 409/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 417/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
16.
METALLIC COATED GASKETS USEFUL FOR FRONT CONTACTS IN ELECTROLYSIS
A product, in accordance with one aspect of the present invention, includes a gasket comprising: a resiliently deformable electrically insulative portion, and an electrically conductive layer formed directly on the electrically insulative portion. A method for creating a product, in accordance with one aspect of the present invention, includes forming an electrically conductive layer on a resiliently deformable electrically insulative portion of a gasket via physical vapor deposition.
GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION (République de Corée)
Inventeur(s)
Choi, Wonjin
Cho, Changhee
Lee, Taeil
Abrégé
A product includes a substrate having a plurality of kirigami cuts in a surface of the substrate, where longitudinal axes of the kirigami cuts are oriented about orthogonal to a longitudinal axis of the substrate, the plurality of kirigami cuts being arranged to allow flexure of the substrate, and a plurality of catalyst nanostructures on the surface of the substrate. The catalyst nanostructures include a photo-piezoelectric material, where the catalyst nanostructures are aligned substantially along the longitudinal axes of the kirigami cuts.
B01J 35/56 - Structures foraminées ayant des passages ou des canaux traversants, p. ex. monolithes tridimensionnels ou grilles
B01J 35/40 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général caractérisés par leurs dimensions, p. ex. granulométrie
B01J 23/84 - Catalyseurs contenant des métaux, oxydes ou hydroxydes métalliques non prévus dans le groupe du cuivre ou des métaux du groupe du fer en combinaison avec des métaux, oxydes ou hydroxydes prévus dans les groupes avec de l'arsenic, de l'antimoine, du bismuth, du vanadium, du niobium, du tantale, du polonium, du chrome, du molybdène, du tungstène, du manganèse, du technétium ou du rhénium
The present disclosure relates to an energy storage medium apparatus having an electrically conductive anode having a plurality of randomly extending anode portions propagating in three dimensions, and an electrically conductive cathode having a plurality of randomly extending cathode portions propagating in three dimensions. The randomly extending anode portions and the randomly extending cathode portions are interpenetrating in three dimensions while maintaining a separation therebetween.
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
19.
SYSTEMS AND METHODS FOR TUNABLE MAGNETIC FIELD STRENGTH STEREOLITHOGRAPHY PRINTING FOR VOXELATED HIERARCHICAL STRUCTURES
The present disclosure relates to a projection stereolithography apparatus. The apparatus makes use of a light projector for projecting a two dimensional image into a resin vat containing a quantity of photoresponsive resin. A holder structure is provided for supporting a plurality of magnets. The holder structure supports the plurality of magnets such that the plurality of magnets are spaced at least partially around the resin vat. The plurality of magnets generate a magnetic field for controllably aligning molecules in the resin while forming a three dimensional part in a layer-by-layer process using the two dimensional image projected by the light projector.
In one general approach, a product includes an aminopolymer having alkyl substituents coupled directly to carbon atoms in a backbone of the aminopolymer. In another general approach, a method of forming an alkyl substituted aminopolymer includes polymerizing, via ring-opening polymerization, one or more types of heterocyclic monomers thereby creating a first polymer, the one or more types of heterocyclic monomers having at least one alkyl substituent coupled directly to a carbon atom of the associated monomer; and creating, from the first polymer, an alkyl substituted aminopolymer.
The present disclosure relates to an additive manufacturing system for droplet-on-demand jetting to manufacture a part from a feedstock. In one embodiment the system comprises a printhead having a nozzle having first and second orifices for ejecting liquid droplets created from the feedstock, wherein the first and second orifices have at least one differing characteristic. A controller is provided along with a pressure pulse data file which is accessible by the controller, and which contains data needed for generating pressure pulses designed to cause ejection from one or the other of the first and second orifices of the nozzle, as needed, to form the part. A pulse generating subsystem is also included which is responsive to the controller for generating the pressure pulses relative to the nozzle, and causing ejection of liquid droplets from at least one of the first and second orifices of the nozzle.
B41J 2/045 - Machines à écrire ou mécanismes d'impression sélective caractérisés par le procédé d'impression ou de marquage pour lequel ils sont conçus caractérisés par la mise en contact sélective d'un liquide ou de particules avec un matériau d'impression à jet d'encre caractérisés par le procédé de formation du jet en produisant à la demande des gouttelettes ou des particules séparées les unes des autres par pression, p. ex. à l'aide de transducteurs électromécaniques
In one general embodiment, a product includes an aminopolymer having alkyl substituents coupled directly to carbon atoms in a backbone of the aminopolymer. In another general embodiment, a method of forming an alkyl substituted aminopolymer includes polymerizing, via ring-opening polymerization, one or more types of heterocyclic monomers thereby creating a first polymer, the one or more types of heterocyclic monomers having at least one alkyl substituent coupled directly to a carbon atom of the associated monomer; and creating, from the first polymer, an alkyl substituted aminopolymer.
The present disclosure relates to a system for monitoring polymerization of a photo-responsive resin during an additive manufacturing operation involving manufacture of a part from the photo-responsive resin. The may have an optical system for generating a beam of light, a polarizer for polarizing the beam of light to create a linearly polarized light beam, with the linearly polarized light beam forming a first un-scattered beam after passing through a portion of the photo-responsive resin having a first refractive index, and a second scattered sample beam after passing through a second portion of the photo-responsive resin having begun a polymerization process and having a second refractive index. A spatial slight modulator receives the un-scattered beam and the scattered sample beam and controllably varies a phase of one or the other to create multiple images of the photo-responsive resin. A controller subsystem receives and combines the multiple images to create a composite image having increased contrast of the photo-responsive resin.
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
B29C 64/268 - Agencements pour irradiation par faisceaux laserAgencements pour irradiation par faisceaux d’électrons [FE]
B29C 64/255 - Enceintes pour le matériau de construction, p. ex. récipients pour poudre
H04N 7/18 - Systèmes de télévision en circuit fermé [CCTV], c.-à-d. systèmes dans lesquels le signal vidéo n'est pas diffusé
A product, in accordance with one aspect of the present invention, includes an aminopolymer having hydroxyl functional groups coupled directly to carbon atoms in a backbone of the aminopolymer. In another general approach, a method of forming an aminopolymer having hydroxyl functional groups coupled directly to carbon atoms in a backbone of the aminopolymer includes polymerizing a monomer having a protected hydroxyl group coupled to a carbon atom of the monomer, thereby creating a first polymer. An aminopolymer with pendant hydroxyl functionalities is created from the first polymer by, at least in part, removing hydroxyl protecting groups of the protected hydroxyl groups of the first polymer.
The present disclosure relates to an additive manufacturing system for droplet-on-demand jetting to manufacture a part from a feedstock. In one embodiment the system comprises a printhead having a nozzle having first and second orifices for ejecting liquid droplets created from the feedstock, wherein the first and second orifices have at least one differing characteristic. A controller is provided along with a pressure pulse data file which is accessible by the controller, and which contains data needed for generating pressure pulses designed to cause ejection from one or the other of the first and second orifices of the nozzle, as needed, to form the part. A pulse generating subsystem is also included which is responsive to the controller for generating the pressure pulses relative to the nozzle, and causing ejection of liquid droplets from at least one of the first and second orifices of the nozzle.
A product, in accordance with one aspect of the present invention, includes an aminopolymer having hydroxyl functional groups coupled directly to carbon atoms in a backbone of the aminopolymer. In another general embodiment, a method of forming an aminopolymer having hydroxyl functional groups coupled directly to carbon atoms in a backbone of the aminopolymer includes polymerizing a monomer having a protected hydroxyl group coupled to a carbon atom of the monomer, thereby creating a first polymer. An aminopolymer with pendant hydroxyl functionalities is created from the first polymer by, at least in part, removing hydroxyl protecting groups of the protected hydroxyl groups of the first polymer.
The present disclosure relates to a system for monitoring polymerization of a photo-responsive resin during an additive manufacturing operation involving manufacture of a part from the photo-responsive resin. The may have an optical system for generating a beam of light, a polarizer for polarizing the beam of light to create a linearly polarized light beam, with the linearly polarized light beam forming a first un-scattered beam after passing through a portion of the photo-responsive resin having a first refractive index, and a second scattered sample beam after passing through a second portion of the photo-responsive resin having begun a polymerization process and having a second refractive index. A spatial slight modulator receives the un-scattered beam and the scattered sample beam and controllably varies a phase of one or the other to create multiple images of the photo-responsive resin. A controller subsystem receives and combines the multiple images to create a composite image having increased contrast of the photo-responsive resin.
An optically addressable light valve (OALV) is disclosed which has a liquid crystal having an input side and an output side. The OALV also has a photoconductor having an input side and an output side, and a dopant providing increased damage tolerance for the photoconductor. A polarizer is also provided which is arranged downstream of the liquid crystal, relative to a travel of light through the OALV. A conductive material is also provided which is applied to the input side of the photoconductor.
G02F 1/135 - Cellules à cristaux liquides associées structurellement avec une couche photoconductrice ou ferro-électrique dont les caractéristiques peuvent être optiquement ou électriquement modifiées
G02F 1/1335 - Association structurelle de cellules avec des dispositifs optiques, p. ex. des polariseurs ou des réflecteurs
29.
TITANIA-BASED DUAL FUNCTIONAL MATERIALS FOR REACTIVE CAPTURE AND CONVERSION OF CO2 TO METHANE AND OTHER PRODUCTS
This disclosure provides dual function materials (DFMs) useful in reactive carbon capture (RCC) processes with physical and chemical characteristics that provide an attractive alternative to direct air capture (DAC) and combine the steps of CO2 adsorption, extraction, and upgrading into one process, thereby eliminating the need for compression and transportation of the captured CO2. This disclosure also provides methods of making and using these DFMs.
B01D 53/73 - Post-traitement des composants éliminés
B01D 53/82 - Procédés en phase solide avec des réactifs à l'état stationnaire
B01J 20/04 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des composés des métaux alcalins, des métaux alcalino-terreux ou du magnésium
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
C07C 1/12 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure à partir d'oxydes de carbone à partir d'anhydride carbonique avec de l'hydrogène
30.
MECHANICALLY ROBUST MULTIMATERIAL FOR ADDITIVE MANUFACTURING
A precursor resin mixture for forming a multimaterial includes a multifunctional monomer comprising two or more first functional groups bonded to a base molecule and two or more terminal functional groups having a double-bonded carbon, a multifunctional thiol monomer having one or more second functional groups positioned between terminal thiol groups, and epoxy monomer, and a curing agent. Regarding the multifunctional monomer, the terminal functional groups being different than the first functional groups.
In an industrial control system (ICS), latent vectors are generated to represent identity or behaviors of host devices coupled to the ICS. A computing system captures communications transmitted by a host device across a network associated with the ICS. A set of values are extracted from one or more respective fields in the communication, then applied to a trained neural network. Values of a first set of fields are applied at an input layer of the trained neural network, while values of a second set of fields are applied at an output layer of the neural network. Based on the application of the neural network to the values extracted from the communication, the computing system generates a latent vector.
Provided herein are compounds and compositions thereof that may be capable of disrupting, interrupting, and/or preventing an interaction between a small GTPase protein and a PI3K protein (e.g., PI3Ka). The present disclosure also provides methods of treating cancers and other indications with such compounds or compositions thereof.
Provided herein are compounds and compositions thereof that may be capable of disrupting, interrupting, and/or preventing an interaction between a small GTPase protein and a PI3K protein (e.g., PI3Ka). The present disclosure also provides methods of treating cancers and other indications with such compounds or compositions thereof.
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
A61K 31/4365 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique ayant le soufre comme hétéro-atome du cycle, p. ex. ticlopidine
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61K 31/438 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle étant condensé en spiro avec des systèmes carbocycliques ou hétérocycliques
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/501 - PyridazinesPyridazines hydrogénées non condensées et contenant d'autres hétérocycles
A61K 31/502 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. cinnoline, phtalazine
A61K 31/5025 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/541 - Thiazines non condensées contenant d'autres hétérocycles
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
33.
ACTIVE SELF-RELEASING MOLDS FOR CASTING OF COMPLEX PARTS
A product includes a three-dimensional structure including a shape changing material, where the three-dimensional structure has a predefined cavity configured to function as a mold for a castable material. The three-dimensional structure is characterized as exhibiting a shape change in response to a stimulus, where the shape change is reversible. The three-dimensional structure is configured to release the castable material in response to the stimulus.
B29C 33/38 - Moules ou noyauxLeurs détails ou accessoires caractérisés par la matière ou le procédé de fabrication
B29C 33/40 - Matière plastique, p. ex. mousse ou caoutchouc
B29C 33/50 - Moules ou noyauxLeurs détails ou accessoires comportant des moyens ou conçus spécialement pour faciliter le démoulage d'objets, p. ex. des objets à contre-dépouille avec des moyens rétractables ou démontables élastiques
B29C 39/02 - Moulage par coulée, c.-à-d. en introduisant la matière à mouler dans un moule ou entre des surfaces enveloppantes sans pression significative de moulageAppareils à cet effet pour la fabrication d'objets de longueur définie, c.-à-d. d'objets séparés
B33Y 80/00 - Produits obtenus par fabrication additive
34.
STABLE NANOLIPOPROTEIN PARTICLES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
Nanolipoprotein particles having at least a scaffold protein component and a membrane lipid component and related compositions, methods and systems are described. The membrane lipid component includes at least one or more membrane forming lipids, one or more polymerized lipids and/or one or more polymerizable lipids.
A61K 9/1273 - PolymersomesLiposomes comportant des substances polymérisables ou polymérisées formant des bicouches
A61K 9/1278 - Chargement ultérieur, p. ex. par gradient ionique ou de pH
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A product includes a three-dimensional structure including a shape changing material, where the three-dimensional structure has a predefined cavity configured to function as a mold for a castable material. The three-dimensional structure is characterized as exhibiting a shape change in response to a stimulus, where the shape change is reversible. The three-dimensional structure is configured to release the castable material in response to the stimulus.
The present disclosure relates to an apparatus for coating rollable elements. The apparatus may have a coating subsystem for generating a coating material, and a conical, dish-like element or an array of rotating rods for supporting the rolling elements thereon for rolling motion during a coating process during which the rolling elements receive the coating material. The conical dish-like element has a plurality of spaced apart track elements for supporting the rolling elements thereon. The array of rods has a plurality of spaced apart grooves for supporting the rolling elements. The openings between track elements or rotating rods allow for particulates and/or contaminants to pass during the coating process.
C23C 14/22 - Revêtement par évaporation sous vide, pulvérisation cathodique ou implantation d'ions du matériau composant le revêtement caractérisé par le procédé de revêtement
37.
SYSTEMS AND METHODS FOR ADDITIVE MANUFACTURE EXTRUSION DIVERTER VALVE AND SENSOR ASSEMBLY
The present disclosure relates to an apparatus for extruding material to make a part using a flowable feedstock printing material. In one embodiment the apparatus makes use of a controller and a print nozzle system. The print nozzle system includes a nozzle housing for receiving the flowable feedstock material, and a nozzle element from which the flowable feedstock material is extruded. A valve system is included which communicates with the controller for controllably interrupting and restarting a flow of the flowable feed during a print operation.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
Disclosed are monolithic optical systems using an aerogel molded around a mandrel. A method of manufacturing an optical system includes applying a reflective coating to at least a portion of a surface of a mandrel, placing the mandrel in a tank and subsequently filling the tank with aerogel to a predetermined depth below a top of the mandrel. The method includes adding a separation layer to the tank on top of the aerogel at the predetermined depth, catalyzing the separation layer into a solid, and adding aerogel on top of the separation layer filling the tank with aerogel above a height of the mandrel, and removing the aerogel and mandrel from the tank, drying the aerogel into a solid aerogel structure, catalyzing the reflective coating to bond the reflective coating with the aerogel, and removing the mandrel from the aerogel structure to produce the aerogel structure having a hollowed-out interior.
G02B 23/02 - Télescopes ou lunettes d'approche, p. ex. jumellesPériscopesInstruments pour voir à l'intérieur de corps creuxViseursPointage optique ou appareils de visée comprenant des prismes ou des miroirs
B29D 11/00 - Fabrication d'éléments optiques, p. ex. lentilles ou prismes
B29K 105/00 - Présentation, forme ou état de la matière moulée
G02B 7/18 - Montures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques pour prismesMontures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques pour miroirs
G02B 7/182 - Montures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques pour prismesMontures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques pour miroirs pour miroirs
G02B 7/183 - Montures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques pour prismesMontures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques pour miroirs pour miroirs spécialement adaptés à de très grands miroirs, p. ex. pour l'astronomie
The present disclosure relates to an apparatus for extruding material to make a part using a flowable feedstock printing material. In one embodiment the apparatus makes use of a controller and a print nozzle system. The print nozzle system includes a nozzle housing for receiving the flowable feedstock material, and a nozzle element from which the flowable feedstock material is extruded. A valve system is included which communicates with the controller for controllably interrupting and restarting a flow of the flowable feed during a print operation.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
An optically addressable light valve comprises a first transparent conductor layer, a layer of liquid crystal, and a photoconductor comprising an ultrawide band gap (UWBG) semiconductor. The liquid crystal is between the first transparent conductor layer and the semiconductor photoconductor. The optically addressable light valve is configured to apply a voltage across the liquid crystal and the UWBG semiconductor. A second transparent conductor may be formed in the UWBG semiconductor in some configurations, and the voltage may be applied across the first and second transparent conductor.
A resin, in accordance with one aspect of the present invention, includes silica, one or more multifunctional monomers, a solvent for promoting dispersion of the silica in the resin, a dispersing agent, and a photoinitiator. A product, in accordance with one aspect, includes a printed glass part having cross-sectional dimensions, along (imaginary) lines in every direction intersecting a point within the printed glass part, of greater than 5 mm. A process, in accordance with one aspect, includes forming a part from a resin, the resin comprising silica, one or more multifunctional monomers, a solvent for promoting dispersion of the silica in the resin, a dispersing agent, and a photoinitiator. The one or more multifunctional monomers are polymerized to form one or more polymers during and/or after the forming. The formed part is dried. The one or more polymers are removed from the dried part. The dried part is sintered.
C08F 120/28 - Esters contenant de l'oxygène en plus de l'oxygène de la fonction carboxyle ne contenant pas de cycles aromatiques dans la partie alcool
B33Y 70/10 - Composites de différents types de matériaux, p. ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
C03B 19/06 - Autres méthodes de façonnage du verre par frittage
C08F 2/50 - Polymérisation amorcée par énergie ondulatoire ou par rayonnement corpusculaire par la lumière ultraviolette ou visible avec des agents sensibilisants
Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
43.
PHOTOPOLYMER RESIN FORMULATION FOR FABRICATION OF SOLID SILICA GLASS STRUCTURES WITH FEATURE SIZES GREATER THAN 5 MM
A resin, in accordance with one aspect of the present invention, includes silica, one or more multifunctional monomers, a solvent for promoting dispersion of the silica in the resin, a dispersing agent, and a photoinitiator. A product, in accordance with one aspect, includes a printed glass part having cross-sectional dimensions, along (imaginary) lines in every direction intersecting a point within the printed glass part, of greater than 5 mm. A process, in accordance with one aspect, includes forming a part from a resin, the resin comprising silica, one or more multifunctional monomers, a solvent for promoting dispersion of the silica in the resin, a dispersing agent, and a photoinitiator. The one or more multifunctional monomers are polymerized to form one or more polymers during and/or after the forming. The formed part is dried. The one or more polymers are removed from the dried part. The dried part is sintered.
C08F 220/18 - Esters des alcools ou des phénols monohydriques des phénols ou des alcools contenant plusieurs atomes de carbone avec l'acide acrylique ou l'acide méthacrylique
C08F 2/44 - Polymérisation en présence d'additifs, p. ex. plastifiants, matières colorantes, charges
C08F 2/48 - Polymérisation amorcée par énergie ondulatoire ou par rayonnement corpusculaire par la lumière ultraviolette ou visible
C08F 2/24 - Polymérisation en émulsion utilisant des agents émulsifiants
B29C 64/129 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p. ex. par irradiation globale combinée avec un masque
B33Y 70/10 - Composites de différents types de matériaux, p. ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
In one general embodiment, a method includes, during performance of an additive manufacturing process that includes photocuring of a resin, monitoring light output generated by a fluorophore in the resin that exhibits aggregation-induced emission (AIE) behavior. An indication of an extent of photocuring is output based on the monitored light output. In another general embodiment, a resin for additive manufacturing includes molecules configured for photopolymerization and/or photocuring, the molecules being selected from the group consisting of monomers, oligomers, and polymers; a photoinitiator; and a fluorophore that exhibits aggregation-induced emission (AIE) behavior. The fluorophore is present in an amount of at least 0.00005 wt % relative to a total weight of the resin. In yet another general embodiment, a three-dimensional encrypted structure includes a fluorophore that exhibits aggregation-induced emission (AIE) behavior. The structure has information encoded therein via the fluorophore, the information being viewable by illuminating the fluorophore with fluorescent light.
B29C 64/00 - Fabrication additive, c.-à-d. fabrication d’objets en trois dimensions [3D] par dépôt additif, agglomération additive ou stratification additive, p. ex. par impression en 3D, stéréolithographie ou frittage laser sélectif
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
45.
SYSTEMS AND METHODS FOR GENERATING GLASS-ENGRAVED NANOSCALE GRATING PERIODS FOR BIREFRINGEMENT METASURFACES
The present disclosure relates to a system for creating parallel, near-linear features with a desired period on a surface of a workpiece, where the workpiece includes a planar substrate and a material layer formed on the planar substrate. In one embodiment the system has an etching beam generator configured to generate a processing beam, and a support structure for holding a workpiece. The workpiece is held such that an upper surface of the material layer of the workpiece is supported at an angle which is non-normal to a direction of travel of the processing beam. The angle correlates to a desired period of features to be fabricated on the upper surface of the material layer. The processing beam transforms the material layer to create generally parallel, generally linear features having the desired a period. Subsequent normal incidence etching may be used to transfer this material layer grating mask structure to the underlying substrate.
A method includes masking a carbon-containing single crystal for defining masked regions and unmasked regions on the single crystal. The method also includes performing a plasma etch for removing portions of the unmasked regions of the single crystal, thereby defining a pillar in each unmasked region, and performing a chemical etch on the pillars at a temperature between 1200° C. and 1600° C. for selectively reducing a width of each pillar.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
B81B 1/00 - Dispositifs sans éléments mobiles ou flexibles, p. ex. dispositifs capillaires microscopiques
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
47.
SPATIO-TEMPORAL MONITORING OF PHOTOPOLYMERIZATION PROGRESSION AND RELATED MECHANISMS
In one general aspect, a method includes, during performance of an additive manufacturing process that includes photocuring of a resin, monitoring light output generated by a fluorophore in the resin that exhibits aggregation-induced emission (AIE) behavior. An indication of an extent of photocuring is output based on the monitored light output. In another general aspect, a resin for additive manufacturing includes molecules configured for photopolymerization and/or photocuring, the molecules being selected from the group consisting of monomers, oligomers, and polymers; a photoinitiator; and a fluorophore that exhibits aggregation-induced emission (AIE) behavior. The fluorophore is present in an amount of at least 0.00005 wt% relative to a total weight of the resin. In yet another general aspect, a three-dimensional encrypted structure includes a fluorophore that exhibits aggregation-induced emission (AIE) behavior. The structure has information encoded therein via the fluorophore, the information being viewable by illuminating the fluorophore with fluorescent light.
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/112 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des gouttelettes individuelles, p. ex. de buses de jet
B33Y 40/00 - Opérations ou équipements auxiliaires, p. ex. pour la manipulation de matériau
B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
C08F 2/44 - Polymérisation en présence d'additifs, p. ex. plastifiants, matières colorantes, charges
C08F 2/50 - Polymérisation amorcée par énergie ondulatoire ou par rayonnement corpusculaire par la lumière ultraviolette ou visible avec des agents sensibilisants
Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a Q61H, G12D, G12V, G12C, G12S, G12A, G12R, or G13D mutation or wild-type KRAS, including wild-type amplified KRAS) and treating diseases or disorders such as cancers in subjects in need thereof.
C07D 409/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 409/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 31/5517 - 1,4-Benzodiazépines, p. ex. diazépam condensées avec des cycles à cinq chaînons ayant l'azote comme hétéro-atome d'un cycle, p. ex. imidazobenzodiazépines, triazolam
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/5386 - 1,4-Oxazines, p. ex. morpholine condensées en spiro ou formant une partie de systèmes cycliques pontés
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 31/5395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un oxygène comme hétéro-atomes d'un cycle, p. ex. 1,2-oxazines ayant plusieurs atomes d'azote dans le même cycle, p. ex. oxadiazines
49.
SYSTEMS AND METHODS FOR IMPROVED LIQUID DROPLET EJECTION FROM A GAS PRESSURIZED PRINTHEAD VIA ARBITRARY PRESSURE AND VACUUM PULSED WAVEFORMS
The present disclosure relates to a system for droplet-based printing and makes use of a controller and a printhead system. The printhead system has a housing with an internal cavity and a nozzle at a lower end thereof. The internal cavity is configured to hold a quantity of liquid feedstock material. The housing also has a feedstock infeed port for enabling a feedstock material to be fed into the internal cavity. A valve system is used which is in communication with the controller and configured to selectively pressurize the internal cavity in response to control signals received from the controller. The control signals cause operations including a vacuum to be applied to the internal cavity, as well as the internal cavity to be vented to atmosphere as well as pressurized, to thus create a pressure waveform with characteristics tailored to characteristics of the feedstock material, which causes ejection of at least one of a droplet or a material jet that controllably breaks into droplets from the nozzle.
B29C 64/112 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des gouttelettes individuelles, p. ex. de buses de jet
B29C 64/255 - Enceintes pour le matériau de construction, p. ex. récipients pour poudre
A product includes a three-dimensional structure comprising a continuous metallic material. The continuous metallic material includes at least two layers. A first layer of the at least two layers includes a metal and a second layer of the at least two layers includes a transition metal having a body-centered-cubic crystal structure. A method of forming a three-dimensional structure having a continuous metallic material includes forming a polymer template, depositing a seed layer on the polymer template, and depositing a metallic layer on the seed layer. The metallic layer includes a transition metal that is nucleated by the seed layer thereby forming the continuous metallic material having a body-centered-cubic crystal structure.
Aspects of this technical solution can include transporting one or more microreactors comprising one or more polypeptides and one or more putative binding partners through a channel of an interrogation chamber, capturing data corresponding to the one or more microreactors comprising the one or more polypeptides and one or more putative binding partners in the channel, determining one or more binding affinities of the one or more polypeptides to the one or more putative binding partners based on the captured data, and generating, by a machine learning model (e.g., a neural network) receiving input based on the one or more binding affinities, output indicative of one or more predicted amino acid sequences of a polypeptide.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
52.
UTILIZING TRACE AMOUNTS OF A SUSPECTED TARGET MOLECULE AS A CATALYST IN DETECTION REACTIONS
A method for detecting a suspected target molecule includes obtaining a reaction mixture that is not reactive at ambient temperature, the reaction mixture comprising at least two reactants, adding the suspected target molecule to the reaction mixture for causing a reaction involving the reactants in the reaction mixture, and detecting presence of a product formed from the reactants in response to the addition of the suspected target molecule. The suspected target molecule acts as a catalyst for the reaction, where the suspected target molecule includes a tertiary amine.
G01N 33/94 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des narcotiques
The Board of Trustees of the University of Illinois (USA)
Inventeur(s)
Biener, Juergen
Ye, Jianchao
Kim, Sangil
Abrégé
Material processing composites, devices, methods of use, and methods of manufacturing using composites having three-dimensional interpenetrating channels separated by porous walls. Such composites include composites having a first flow channel and a second flow channel defined and separated by porous (e.g., nanoporous) walls, wherein the first flow channel and the second flow channels have a three-dimensional interpenetrating structure. The first flow channel and the second flow channel may have a triply periodic minimal surface structure, such as a gyroid or Schwartz surface structure. In some embodiments, the composite is configured for use in hemofiltration, molecular filtration, gas purification, energy storage, or chemical conversion.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C. depressing a glass transition temperature (Tg) of the SMP foam to below 25° C. Other embodiments are described herein.
A61L 15/18 - Bandages, pansements ou garnitures absorbant les fluides physiologiques tels que l'urine, le sang, p. ex. serviettes hygiéniques, tampons contenant des matériaux inorganiques
A61L 15/26 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carboneLeurs dérivés
A61L 15/42 - Utilisation de matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 15/46 - Désodorisants ou produits pour neutraliser les mauvaises odeurs, p. ex. pour inhiber la formation d'ammoniac ou la multiplication de bactéries
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.
A61B 17/12 - Instruments, dispositifs ou procédés chirurgicaux pour ligaturer ou comprimer par un autre moyen les parties tubulaires du corps, p. ex. les vaisseaux sanguins ou le cordon ombilical
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
The present disclosure relates to an additive manufacturing system for building a part from a feedstock material on a build table. The system may make use of a plurality of electrodes in contact with the build table, and a current source configured to provide an electrical current, via a first subplurality of the plurality of electrodes, to the build table. A second subplurality of the plurality of electrodes is configured in contact with a surface of the build table. A voltage measuring subsystem is operably associated with the second subplurality of the plurality of electrodes and configured to measure a potential different between two points on the build table at least one of while, or after, a sintering operation is performed on the feedstock material.
A method of fabricating metamaterial structures without exceeding 30° C. or less in temperature comprises forming a metasurface mask by depositing a layer of nanoparticles on a surface of the substrate, etching the surface of the substrate with the nanoparticles thereon using reactive ion beam etching (RIBE), and removing at least a portion of the nanoparticles from the etched surface. Nanometer size surface features are thereby formed on the surface of a material without exceeding 30° C. in temperature, thereby forming metamaterial structures with a reduced incidence of thermal damage to the material.
Plasma and gas based optics may be used to direct light to a target that produces emission harmful to solid-state optics. In some cases, a shield having a hole, opening or separation for the light to pass may be employed to attenuate or block such harmful emission from the target thereby providing some protection for the solid-state optics. In some designs, the light incident on the target is not coaxial with light sources such as pump and/or seed sources providing beams incident on the plasma or gas based optics. In various designs, however, the plasma or gas based optic(s) is resistant to the emissions from the target.
The present disclosure relates to a method for performing an additive manufacturing operation to form a structure by processing a photopolymer resist material. A laser beam is directed at a tunable mask. At least one emergent beam is collected from a plurality of emergent beams emerging from the tunable mask. The at least one emergent beam is collimated to create a collimated beam. Each emergent beam from the tunable mask has a plurality of beamlets of varying or identical intensity, and each beamlet emerges from a unique subsection or region of the tunable mask. The collimated beam is focused into a laser beam which is projected as an image plane onto or within the photopolymer resist material, such that the same optical path length is created between the tunable mask and the focused image plane for all optical frequencies of the focused laser beam. The focused laser beam illuminates a select pattern of subsections on the tunable mask for a finite duration of time to cause simultaneous polymerization of select portions of the photopolymer resist material corresponding to the select pattern.
B29C 64/135 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p. ex. par irradiation globale combinée avec un masque la source d’énergie étant concentrée, p. ex. lasers à balayage ou sources lumineuses focalisées
B29C 64/268 - Agencements pour irradiation par faisceaux laserAgencements pour irradiation par faisceaux d’électrons [FE]
B29C 64/273 - Agencements pour irradiation par faisceaux laserAgencements pour irradiation par faisceaux d’électrons [FE] à pulsationsAgencements pour irradiation par faisceaux laserAgencements pour irradiation par faisceaux d’électrons [FE] à modulation de fréquence
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
G02B 26/08 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la direction de la lumière
G02B 27/28 - Systèmes ou appareils optiques non prévus dans aucun des groupes , pour polariser
G03F 7/00 - Production par voie photomécanique, p. ex. photolithographique, de surfaces texturées, p. ex. surfaces impriméesMatériaux à cet effet, p. ex. comportant des photoréservesAppareillages spécialement adaptés à cet effet
An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
A product includes a material formed above a substrate, the material comprising: a plurality of particles configured to complete a self-propagating and/or self-sustaining reaction upon initiation thereof; a solvent system; and one or more stabilizing agents. The product may include one, or multiple layers of the plurality of particles, and/or may include additional layers of a second material, which may be a non-energetic material. The particles may be configured to form a glass, an alloy, a ceramic, or a cermet upon completion of the self-propagating and/or self-sustaining reaction. The self-propagating and/or self-sustaining reaction may include an intermetallic reaction and/or a thermite reaction, may perform thermal work on the substrate, and/or may be completed in vacuum or an aqueous environment. A spatial configuration of the material, a structure in the substrate, and/or a symbol on surface(s) of the substrate may be formed upon completion of the self-propagating and/or self-sustaining reaction.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
C09D 11/03 - Encres d’imprimerie caractérisées par des particularités autres que la nature chimique du liant
62.
SYSTEMS AND METHODS FOR ELECTRICAL RESISTANCE DIAGNOSTIC FOR CONDUCTIVITY MONITORING IN LASER POWDER BED FUSION
The present disclosure relates to an additive manufacturing system for building a part from a feedstock material on a build table. The system may make use of a plurality of electrodes in contact with the build table, and a current source configured to provide an electrical current, via a first subplurality of the plurality of electrodes, to the build table. A second subplurality of the plurality of electrodes is configured in contact with a surface of the build table. A voltage measuring subsystem is operably associated with the second subplurality of the plurality of electrodes and configured to measure a potential different between two points on the build table at least one of while, or after, a sintering operation is performed on the feedstock material.
In one general approach, a heat conducting insert for a reactor includes a center portion, a cross member extending outwardly from the center portion in a radial direction, and at least two branches extending outwardly from the cross member and away from the center portion. Each of the branches has an outer portion extending laterally from a distal end of the respective branch along a portion of an imaginary semicircle. In another general approach, a heat conducting insert for a reactor includes a center portion, a cross member, an outer portion extending laterally from a distal end of the cross member along a portion of an imaginary semicircle, and at least two branches extending outwardly from the cross member from a location on the cross member located between the center portion and the outer portion, wherein distal ends of the branches extend toward, but do not extend to, the semicircle.
B01J 19/32 - Éléments de remplissage en forme de grille ou d'éléments composés de plusieurs pièces pour constituer une unité ou un module dans l'appareil de transfert de chaleur ou de matière
B01J 8/02 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules immobiles, p. ex. dans des lits fixes
B01J 8/06 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules immobiles, p. ex. dans des lits fixes dans des réacteurs tubulairesProcédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules immobiles, p. ex. dans des lits fixes les particules solides étant disposées dans des tubes
C10G 2/00 - Production de mélanges liquides d'hydrocarbures de composition non définie à partir d'oxydes de carbone
In one general approach, a heat conducting insert for a reactor includes a center portion, a cross member extending outwardly from the center portion in a radial direction, and at least two branches extending outwardly from the cross member and away from the center portion. Each of the branches has an outer portion extending laterally from a distal end of the respective branch along a portion of an imaginary semicircle. In another general approach, a heat conducting insert for a reactor includes a center portion, a cross member, an outer portion extending laterally from a distal end of the cross member along a portion of an imaginary semicircle, and at least two branches extending outwardly from the cross member from a location on the cross member located between the center portion and the outer portion, wherein distal ends of the branches extend toward, but do not extend to, the semicircle.
B01J 8/06 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules immobiles, p. ex. dans des lits fixes dans des réacteurs tubulairesProcédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules immobiles, p. ex. dans des lits fixes les particules solides étant disposées dans des tubes
A diffractive optical element, such as a holographic plasma lens, can be made by direction two laser beams so that they overlap in a nonlinear material, to form an interference pattern in the nonlinear material. The interference pattern can modify the index of refraction in the nonlinear material to produce the diffractive optical element. The interference pattern can modify the distribution of plasma for the nonlinear material, which can adjust the index of refraction. A third laser beam can be directed through the diffractive optical element to modify the third laser beam, such as to focus, defocus, or collimate the third laser beam.
A polyolefin-based ink for additive manufacturing includes a polyolefin comprising at least one type of functional group for crosslinking, where the polyolefin includes at least an ethylene monomeric unit and at least a propylene monomeric unit. The ethylene monomeric unit is present in a range of greater than 50 wt. % to about 75 wt. % of a total weight of the polyolefin. Moreover, the polyolefin has a molecular weight that is no more than five times the entanglement molecular weight of a homologous series of the polyolefin.
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
B33Y 70/10 - Composites de différents types de matériaux, p. ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
C09D 11/037 - Encres d’imprimerie caractérisées par des particularités autres que la nature chimique du liant caractérisées par le pigment
67.
SKIN-LAYERED POROUS SEPARATORS AND RELATED METHODS
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (USA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventeur(s)
Biener, Juergen
Huang, Sijia
Feng, Longsheng
Ye, Jianchao
Ma, Meghann Christine
Li, Donglin
Wang, Kun
Kim, Sangil
Wan, Jiandi
Abrégé
A product, in accordance with one aspect of the present invention, includes a porous first layer having a first porosity, and a porous skin layer having a second porosity that is relatively lower than the first porosity. The skin layer is a self-formed layer. A method, in accordance with one aspect of the present invention, includes contacting a resin with a separator. The resin is exposed to radiation for curing the resin, thereby simultaneously creating a porous first layer and a porous skin layer positioned between the first layer and the separator. The first layer has a first porosity. The skin layer has a second porosity that is relatively lower than the first porosity.
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
H01M 50/403 - Procédés de fabrication des séparateurs, des membranes ou des diaphragmes
H01M 50/414 - Résines synthétiques, p. ex. thermoplastiques ou thermodurcissables
H01M 50/449 - Séparateurs, membranes ou diaphragmes caractérisés par le matériau ayant une structure en couches
68.
SKIN-LAYERED POROUS SEPARATORS AND RELATED METHODS
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (USA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
Inventeur(s)
Biener, Juergen
Huang, Sijia
Feng, Longsheng
Ye, Jianchao
Ma, Meghann, Christine
Li, Donglin
Wang, Kun
Kim, Sangil
Wan, Jiandi
Abrégé
A product, in accordance with one aspect of the present invention, includes a porous first layer having a first porosity, and a porous skin layer having a second porosity that is relatively lower than the first porosity. The skin layer is a self-formed layer. A method, in accordance with one aspect of the present invention, includes contacting a resin with a separator. The resin is exposed to radiation for curing the resin, thereby simultaneously creating a porous first layer and a porous skin layer positioned between the first layer and the separator. The first layer has a first porosity. The skin layer has a second porosity that is relatively lower than the first porosity.
A newly developed generalizable screening method enables efficient identification of epitopes, in the proteomes of pathogenic agent is provided. Also disclosed are systems that enable the method as well as epitopes discovered using the method.
C40B 30/04 - Procédés de criblage des bibliothèques en mesurant l'aptitude spécifique à se lier à une molécule cible, p. ex. liaison anticorps-antigène, liaison récepteur-ligand
C40B 40/10 - Bibliothèques comprenant des peptides ou des polypeptides ou leurs dérivés
G16B 20/30 - Détection de sites de liaison ou de motifs
The present disclosure relates to a system for selective powder deposition (SPD) printing a part or structure. In one embodiment the system makes use of a print nozzle having a nozzle tip portion. A vibrational element is associated with the nozzle tip portion and receives an excitation signal from an excitation subsystem and generates vibrational energy which is imparted into the powder particles within the print nozzle. The vibrational element imparts the vibrational energy to the powder particles as they are deposited, which assists in compacting the powder particles.
Devices, methods and techniques related to the use of a photoconductive semiconductor switch (PCSS) to drive a high-power laser diode for a wide range of pulse widths are disclosed. In one example aspect, a circuit for driving one or more laser diodes includes an input port configured to be coupled to a voltage input, one or more inductors that are configured to be in series with the one or more laser diodes, a photoconductive switch coupled with the one or more inductors, and an output port configured to be coupled to the one or more laser diodes.
H01S 5/06 - Dispositions pour commander les paramètres de sortie du laser, p. ex. en agissant sur le milieu actif
H01S 5/32 - Structure ou forme de la région activeMatériaux pour la région active comprenant des jonctions PN, p. ex. hétérostructures ou doubles hétérostructures
Devices, methods and techniques related to the use of a photoconductive semiconductor switch (PCSS) to drive a high-power laser diode for a wide range of pulse widths are disclosed. In one example aspect, s circuit for driving one or more laser diodes includes an input port configured to be coupled to a voltage input, one or more inductors that are configured to be in series with the one or more laser diodes, a photoconductive switch coupled with the one or more inductors, and an output port configured to be coupled to the one or more laser diodes.
H01S 5/062 - Dispositions pour commander les paramètres de sortie du laser, p. ex. en agissant sur le milieu actif en faisant varier le potentiel des électrodes
73.
SYSTEMS AND METHODS FOR USING DIRECT INK WRITING TO MAKE A 3D ELECTROMAGNET
A system for direct ink write printing an elongated conductive element. The system may involve a controller and a print nozzle configured to extrude first and second materials. The first material may be an electrically conductive material, and the second material may be an electrical insulator. A motion control subsystem is in communication with the controller for controlling movement of the print nozzle system along a non-linear pattern in X, Y and Z axes, in a manner to encase a bead of the first material fully within the second material, to thus form the elongated conductive element.
Methods and apparatus for stochastically heating charged reactants by applying a random (stochastic) voltage signal to a working electrode, thereby inducing a stochastic electric field. By agitating the charged species in the interfacial region adjacent the working electrode or other target substrate, the stochastic electric field increases the effective temperature of the charged species while scarcely affecting any surrounding neutral molecules (e.g., water). This effect increases the reaction rates in the interfacial region and can allow the reactants to achieve rates that are commensurate with physically inaccessible temperatures in common solutions.
A vascularizing, crack sealing and/or corrosion reducing repair formulation for concrete, and corresponding methods. In one general embodiment, a repair formulation includes a casting material, and an encapsulated and/or non-encapsulated biological material in the casting material. The biological material is operative to enable concrete and/or mortar structural healing. A method for non-destructive evaluation of cementitious material, in accordance with one general embodiment, includes causing a repair formulation to vascularize along a crack in the cementitious material via a biological and/or non-biological effect, characterizing the vascularized repair formulation, and outputting a result derived from the characterization.
An ink includes a thermoplastic polymer and a solvent effective to melt the thermoplastic polymer. A method includes forming a three-dimensional (3D) structure using an ink, the ink includes a thermoplastic polymer and a solvent effective to melt the thermoplastic polymer. The method includes removing the solvent from the 3D structure, where the thermoplastic polymer remains substantially in the shape of the formed 3D structure after removal of the solvent.
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
B33Y 40/00 - Opérations ou équipements auxiliaires, p. ex. pour la manipulation de matériau
B29K 79/00 - Utilisation comme matière de moulage d'autres polymères contenant dans la chaîne principale uniquement de l'azote avec ou sans oxygène ou carbone
B29K 69/00 - Utilisation de polycarbonates comme matière de moulage
Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12D or G12V mutation or wild-type KRAS) and treating diseases or disorders such as cancers in subjects in need thereof.
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
An ink includes a thermoplastic polymer and a solvent selected to melt the thermoplastic polymer. A method includes forming a three-dimensional (3D) structure using an ink, the ink includes a thermoplastic polymer and a solvent selected to melt the thermoplastic polymer. The method includes removing the solvent from the 3D structure, where the thermoplastic polymer remains substantially in the shape of the formed 3D structure after removal of the solvent.
C09D 11/102 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
A product includes a mixture for converting a polyurethane where the mixture includes a functional alcohol and a catalyst. A method of converting polyurethane includes forming a mixture at an ambient temperature where the mixture includes a polyurethane, a functional alcohol, and a catalyst. The method further includes collecting a product from the mixture after a duration of time. The product includes a diallyl urethane monomer and a multi-functional alcohol.
C08J 11/24 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance organique par traitement avec des composés organiques contenant de l'oxygène contenant des groupes hydroxyle
A method comprising: forming a first mask using nanoparticles of metallic material on a surface of a substrate of a component; performing a first etching operation at a first angle relative to the surface of the substrate using a nanoparticle mask to remove material from the surface to create surface features projecting from an upper surface in accordance with the nanoparticle mask; forming a second mask on the upper surface of the substrate by depositing an additional quantity of metallic material at a second angle, different from the first angle, to create a plurality of regions adjacent each one of the rods where the quantity of metallic material is absent; and performing a second etching operation at a third angle using the second mask to create a plurality of voids at each of the regions, the voids helping to form a metasurface which imparts birefringence to the component.
A product includes a mixture for converting a polyurethane where the mixture includes a functional alcohol and a catalyst. A method of converting polyurethane includes forming a mixture at an ambient temperature where the mixture includes a polyurethane, a functional alcohol, and a catalyst. The method further includes collecting a product from the mixture after a duration of time. The product includes a diallyl urethane monomer and a multi-functional alcohol.
C08J 11/24 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance organique par traitement avec des composés organiques contenant de l'oxygène contenant des groupes hydroxyle
C08J 11/28 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance organique par traitement avec des composés organiques contenant de l'azote, du soufre ou du phosphore
C08G 75/045 - Polythioéthers à partir de composés mercapto ou de leurs dérivés métalliques à partir de composés mercapto et de composés insaturés
B29C 64/129 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p. ex. par irradiation globale combinée avec un masque
B33Y 70/10 - Composites de différents types de matériaux, p. ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
B33Y 80/00 - Produits obtenus par fabrication additive
82.
BUILT-IN ELECTROLYZER FOR INCREASING DURABILITY OF A FLOW BATTER BY REBALANCING THE ELECTROLYTE COMPOSITION
Durability of an energy conversion and storage system is increased by rebalancing the electrolyte composition used in the system. The storage system includes a main device, a sub device, an electrolyte, and a device for directing the electrolyte from the main device to the sub device. The system has re-balancing capacity for the electrolyte properties of the electrolyte in the sub device. The as re-balancing capacity includes rebalancing pH of the electrolyte and/or rebalancing conductivity of the electrolyte and/or rebalancing solubility of the electrolyte.
Provided herein are compounds of Formula (I) and Formula (II) and compositions thereof that capable of disrupting, interrupting, and/or preventing an interaction between a small GTPase protein and a PI3K protein (e.g., PI3Kα). The present disclosure also provides methods of treating cancers and other indications with such compounds or compositions thereof. (I) (II)
C07D 237/26 - Composés hétérocycliques contenant des cycles diazine-1, 2 ou diazine-1, 2 hydrogéné condensés avec des carbocycles ou avec des systèmes carbocycliques
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
Provided herein are compounds of Formula I" and Formula II and compositions thereof that are capable of disrupting, interrupting, and/or preventing an interaction between a small GTPase protein and a PI3K protein (e.g., PI3Ka). The present disclosure also provides methods of treating cancers and other indications with such compounds or compositions thereof.
C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
A61K 31/4365 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique ayant le soufre comme hétéro-atome du cycle, p. ex. ticlopidine
A61K 31/4355 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'oxygène comme hétéro-atome du cycle
85.
SYSTEMS AND METHODS FOR HIGH DENSITY ELECTROCHEMICAL ADDITIVE MANUFACTURING WITH CMOS MICROANODE ARRAY
The present disclosure relates to an additive manufacturing system for forming a part. In one embodiment the system may make use of a controller for generating 2D pattern data for printing a part. A cathode may be used which is adapted to be disposed in a solution contained within a reservoir. The cathode is configured for facilitating electrodeposition to form a part thereon. A printhead is provided which has a plurality of microanodes forming a microanode array, and which is in communication with the controller. The printhead is disposed adjacent to the cathode and configured to receive and use the 2D pattern data to generate current signals applied to the microanodes. The microanodes cause electrodeposition of metal, using the solution, on the cathode at a plurality of select locations on the cathode, and in parallel.
B22F 10/30 - Commande ou régulation des opérations
B22F 10/85 - Acquisition ou traitement des données pour la commande ou la régulation de procédés de fabrication additive
B22F 12/50 - Moyens d’alimentation en matériau, p. ex. têtes
B22F 12/90 - Moyens de commande ou de régulation des opérations, p. ex. caméras ou capteurs
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
Various embodiments include constant pressure direct casting into molds to create low surface finish additive manufacturing parts with reduced surface roughness apparatus having a liquid metal print head, a high pressure gas supply line, a pneumatic valve between said liquid metal print head and said high pressure gas supply line, a build plate motion stage, and a stream of metal produced by said liquid metal print head that is directed onto said build plate motion stage to produce the low surface finish additive manufacturing parts with reduced surface roughness.
Various embodiments include constant pressure direct casting into molds to create low surface finish additive manufacturing parts with reduced surface roughness apparatus having a liquid metal print head, a high pressure gas supply line, a pneumatic valve between said liquid metal print head and said high pressure gas supply line, a build plate motion stage, and a stream of metal produced by said liquid metal print head that is directed onto said build plate motion stage to produce the low surface finish additive manufacturing parts with reduced surface roughness.
The present disclosure relates to an additive manufacturing system for forming a part. In one embodiment the system may make use of a controller for generating 2D pattern data for printing a part. A cathode may be used which is adapted to be disposed in a solution contained within a reservoir. The cathode is configured for facilitating electrodeposition to form a part thereon. A printhead is provided which has a plurality of microanodes forming a microanode array, and which is in communication with the controller. The printhead is disposed adjacent to the cathode and configured to receive and use the 2D pattern data to generate current signals applied to the microanodes. The microanodes cause electrodeposition of metal, using the solution, on the cathode at a plurality of select locations on the cathode, and in parallel.
A method of electric field-enhanced impurity diffusion includes obtaining a heterostructure including a substrate of Group-III-nitride semiconductor material, a source layer including a dopant positioned directly on the substrate, and a conductive cap layer positioned above the source layer, and applying a thermal annealing treatment to the heterostructure. An electric field gradient is established within the source layer and the cap layer for causing diffusion of an element from the substrate to the cap layer, and for causing diffusion of the dopant from the source layer to a former location of the element in the substrate thereby changing a conductivity and/or magnetic characteristic of the substrate.
H01L 29/20 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
H01L 21/225 - Diffusion des impuretés, p. ex. des matériaux de dopage, des matériaux pour électrodes, à l'intérieur ou hors du corps semi-conducteur, ou entre les régions semi-conductricesRedistribution des impuretés, p. ex. sans introduction ou sans élimination de matériau dopant supplémentaire en utilisant la diffusion dans ou hors d'un solide, à partir d'une ou en phase solide, p. ex. une couche d'oxyde dopée
Iowa State University Research Foundation, Inc. (USA)
UT-Battelle, LLC (USA)
University of Tennessee Research Foundation (USA)
Eck Industries, Inc. (USA)
Lawrence Livermore National Security, LLC (USA)
Inventeur(s)
Ott, Ryan T.
Rios, Orlando
Sims, Zachary C.
Weiss, David
Kesler, Michael S.
Meng, Fanqiang
Mccall, Scott K.
Henderson, Hunter B.
Abrégé
Production of a bulk Al-RE alloy body (product) using cast billets/ingots (cooling rates<100 C/s) or rapidly solidified Al-RE particulates (cooling rates 102-106° C./second) that have beneficial microstructural refinements that are further refined by subsequent consolidation to produce a consolidated bulk alloy product having excellent mechanical properties over a wide temperature range such as up to and above 230° C.
B21C 29/00 - Refroidissement ou chauffage des produits extrudés ou des parties de la presse d'extrusion
B21C 29/02 - Refroidissement ou chauffage des produits extrudés ou des parties de la presse d'extrusion des conteneurs de métal à extruder
B21C 31/00 - Dispositifs de commande pour extrusion du métal, p. ex. pour réguler la vitesse d'extrusion ou la température du métalDispositifs de mesure, p. ex. pour la température du métal, combinés à des presses d'extrusion ou spécialement adaptés pour être utilisés en association avec ces presses
B22F 3/20 - Fabrication de pièces ou d'objets à partir de poudres métalliques, caractérisée par le mode de compactage ou de frittageAppareils spécialement adaptés à cet effet par extrusion
B22F 9/08 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un matériau liquide par coulée, p. ex. à travers de petits orifices ou dans l'eau, par atomisation ou pulvérisation
C22C 1/02 - Fabrication des alliages non ferreux par fusion
C22C 1/04 - Fabrication des alliages non ferreux par métallurgie des poudres
C22F 1/04 - Modification de la structure physique des métaux ou alliages non ferreux par traitement thermique ou par travail à chaud ou à froid de l'aluminium ou de ses alliages
An optical device provides nonlinear spectral broadening of laser pulses of a laser beam having a spatially varying intensity profile. The device comprises a nonlinear optical element and an optical path difference compensator. The nonlinear optical element has a spatially varying thickness that depends on the spatially varying intensity profile of the laser beam. The optical path difference compensator has a spatially varying thickness that varies such that the optical path length over which the laser beam propagates through the nonlinear optical element and the compensator is spatially more uniform across most of the laser beam cross-section.
H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
92.
SYSTEMS AND METHODS FOR ADDITIVELY MANUFACTURING HIGH STRENGTH AND STIFFNESS FIBER-REINFORCED INORGANIC GLASS COMPOSITE STRUCTURES
The present disclosure relates to a feedstock for performing additive manufacturing through a heated extrusion print nozzle heated to a working printing temperature. The feedstock may have a glass matrix meltable at the working printing temperature and a reinforcing fiber component. The fiber reinforcing component is disposed within the glass matrix, and selected to be at least one of thermally stable or thermally oxidatively stable at the working printing temperature being used to melt the glass matrix.
C03C 14/00 - Compositions de verre contenant un constituant non vitreux, p. ex. compositions contenant des fibres, filaments, trichites, paillettes ou similaires, dispersés dans une matrice de verre
A system for autonomously determining optimal paths without collision through a travel volume for a swarm of vehicles is disclosed. The system determines a travel path for the swarm leader vehicle using a minimal cost path derived from various measures of environmental cost for avoiding objects in traveling from leader location to target location. The system also determines, for each empty neighbor location of each follower vehicle, relational costs for follower vehicle travel relative to leader vehicle travel. The various measures of relational cost seek to maintain a prescribed positional relationship between each follower vehicle and the leader vehicle given the leader vehicle travel path. Based on various measures of environmental and relational cost, the system determines the best travel path for the each follower vehicle relative to the leader vehicle.
G05D 1/00 - Commande de la position, du cap, de l'altitude ou de l'attitude des véhicules terrestres, aquatiques, aériens ou spatiaux, p. ex. utilisant des pilotes automatiques
G01C 21/34 - Recherche d'itinéraireGuidage en matière d'itinéraire
G06Q 10/047 - Optimisation des itinéraires ou des chemins, p. ex. problème du voyageur de commerce
The present disclosure relates to a multi-electrode electrochemical apparatus. In one embodiment the apparatus has a first beam-like structure having a first material coating, with the first beam-like structure forming a first electrode. A second structure is included which has a second material coating. The second structure forms a second electrode. The first and second structures are further configured in an interpenetrating fashion within a defined 3D space to form an electrochemical apparatus, and without physical contact at any point within the defined 3D space.
Provided herein are cell free protein synthesis (CFPS) systems comprising a plurality of ribosomes attached to or encapsulated within a structure, or a plurality of structures, and, optionally, a solid support. Also provided are related kits and uses of the CFPS systems. Methods of producing a protein and methods of treating a disease are provided herein.
C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p. ex. glutathion
A61K 38/00 - Préparations médicinales contenant des peptides
B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
A simulation system provides real-time, flexible, and accurate simulations of radiological scenarios that can provide robust and valuable training experience to users. A radiological scenario simulation provided by a simulation system includes simulated neutron and gamma measurements provided by a neutron simulation service and a gamma simulation service, respectively. Each of the neutron simulation service and the gamma simulation service perform accelerated computational techniques to provide the simulation results to the radiological scenario simulation in real-time. In particular, the neutron simulation service performs a particle-wise simulation with an optimized number of neutron particles, scales detector objects to an increased size, and models fission behavior for a source object based on simulated neutron particles being scattered back into the source object.
A product, according to one general aspect, includes solid state electrolyte particles, each particle individually having a coating thereon, the coating comprising a first metal oxide in a first layer and a second metal oxide in a second layer. The first and second metal oxides are different. A method, according to one general aspect, includes fabricating a product using a powder of solid state electrolyte particles, each particle being coated with a coating formed via 15 cycles or less of atomic layer deposition, the coating comprising a first metal oxide in a first layer and a second metal oxide in a second layer. The first and second metal oxides are different.
C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction
H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif
H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
A neutron activation detector comprises a first enclosure, a plurality of electrical leads, and an activation medium disposed within the enclosure. The activation medium consists substantially of a material that is activated by fast neutrons, and is arranged within the enclosure so that activation of the material by fast neutrons results in a current between the plurality of electrical leads.
A neutron activation detector comprises a first enclosure, a plurality of electrical leads, and an activation medium disposed within the enclosure. The activation medium consists substantially of a material that is activated by fast neutrons, and is arranged within the enclosure so that activation of the material by fast neutrons results in a current between the plurality of electrical leads.
A method of distinguishing between human-generated text and text generated by artificial intelligence (AI) is disclosed. A plurality of first cryptographic digital signatures associated with a set of typed characters are generated. Generating the plurality of first cryptographic digital signatures may include, for each of multiple keystrokes on a physical keyboard: detecting a motion associated with a pressing of a particular key on the physical keyboard, wherein the particular key is associated with a particular character; generating a first cryptographic digital signature associated with the particular character in response to detecting the motion; and providing a typed character and an associated one of the first cryptographic digital signatures to a first verification entity located within a processing device, for verification of a physical keystroke.
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
brevets
