Produits et services

Chemical reagents and biological preparations for diagnosis, other than for medical or veterinary use; reagents and culture media for the monitoring, detection, diagnosis and analysis of microorganisms in industrial, agri-food, cosmetic and pharmaceutical products and in the production environments of these products, namely water, air and work surfaces. Reagents and culture media for pharmaceutical, medical and veterinary use enabling the monitoring, detection, diagnosis and analysis of microorganisms. Scientific apparatus and instruments for diagnosis (not for medical use) and for monitoring and detecting microorganisms in industrial, agri-food, cosmetic and pharmaceutical products and in the production environments of these products, namely water, air and work surfaces; petri dishes. Diagnostic apparatus and instruments for medical and veterinary use; petri dishes for medical and veterinary use; containers for collecting medical and veterinary waste; containers for collecting petri dishes contaminated by microorganisms. Disinfecting, sanitizing, sterilizing and cleaning petri dishes and apparatus and instruments for diagnosing microorganisms; providing information, advice and assistance with respect to the disinfection, sanitation, sterilization and cleaning of petri dishes and apparatus and instruments for diagnosing microorganisms. Collecting and transporting waste, namely petri dishes and apparatus and instruments for diagnosing microorganisms; provision of information, advice and assistance with respect to the collection and transport of waste, namely petri dishes and apparatus and instruments for diagnosing microorganisms. Sorting, recycling, treating and processing waste, namely petri dishes and apparatus and instruments for diagnosing microorganisms; provision of information, advice and assistance with respect to sorting, recycling, treating and processing waste, namely petri dishes and apparatus and instruments for diagnosing microorganisms.

Abrégé

The invention relates to a method for manufacturing a biological analysis card (1) comprising:—a step a) of providing a base (2) formed of:—at least two films (3) placed one on top of the other;—a receiving space (4) formed between the two films (3); —ducts (5) leading to the receiving space (4);—a step b) of placing a plate (9) in the receiving space (4), the plate (9) comprising:—a first face (10a) and a second face connected by an edge (11) having a profile;—a plurality of wells (12) opening onto at least the first face (10a) or the second face;—a plurality of channels (13) fluidly connecting the wells (12);—a welding step c) for welding the two films (3) in the receiving space (4) to the plate (9) and a film (3) to segments of the edge (11) of the plate (9) by applying a heating block to the film (3) against the edge (11) on the side of the first face (10a).

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique

Abrégé

The invention relates to an in vitro or ex vivo method for determining the risk of death for a subject infected with a respiratory virus, said method comprising the steps of measuring, in a biological sample from said subject, the expression level of the OAS2 gene, and comparing the expression level thus measured or a value derived from this amount to a predetermined reference value. The method thus makes it possible to conclude that there is an increased risk of death for the subject when a sub-expression of the OAS2 gene is statistically demonstrated from the biological sample. Advantageously, the measurement of the expression level of OAS2 can be supplemented by a measurement of one or more additional genes such as C3ARI, CD177, ADGRE3, CIITA, IL-10, ILIR2, CD74, TDRD9 and combinations thereof. Kits for measuring the expression of OAS2 and optionally one or more additional genes are also disclosed.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The invention relates to an in vitro or ex vivo method for determining the risk of death in a subject infected with a respiratory virus, for example SARS-CoV-2, comprising a measurement, in a biological sample of said subject, of the level of expression of the CD74 gene; the invention also relates to associated kits.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The disclosed method for classifying microorganisms contained in a sample comprises: preparing a slide of the sample; acquiring at least one digital image of the slide; and implementing, with a computer, a model for predicting the class of the microorganisms depending on the acquired image. According to the invention, said image is subdivided into sub-images and each sub-image is sub-divided into patches, and: A. for each patch, a microorganism feature extractor is applied, the feature extractor forming a convolutional part of a first convolutional neural network trained on patches annotated individually with at least one class; B. for each sub-image, a second neural network connected to the extractor is applied, the second neural network comprising an upstream pooling layer and one or more downstream layers comprising a layer for predicting at least one class, and being trained on training sub-images globally; and C. for the acquired image: F.a. calculating a feature vector calculated for the sub-images; F.b. applying a model for predicting at least one class for the microorganisms.

Classes IPC  ?

• G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
• G06V 10/50 - Extraction de caractéristiques d’images ou de vidéos en effectuant des opérations dans des blocs d’imagesExtraction de caractéristiques d’images ou de vidéos en utilisant des histogrammes, p. ex. l’histogramme de gradient orienté [HoG]Extraction de caractéristiques d’images ou de vidéos en utilisant l’addition des valeurs d’intensité d’imageAnalyse de projection
• G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions

Abrégé

The invention relates to an in vitro method for determining whether a newborn patient has late-onset neonatal sepsis, which comprises determining the PTX-3 protein concentration in a biological sample previously obtained from said patient.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The invention relates to a gelled reaction medium for the detection, identification, enumeration and/or isolation of at least one target microorganism in a simple that may contain same, comprising at least one binding partner specific to a component of a target microorganism or of a component derived from said microorganism, coupled to at least one nanoparticle to form at least one binding conjugate.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/10 - Entérobactéries
• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

The present invention relates to a method for quickly determining the immune status of an individual. The method comprises the following steps: taking a volume of a whole blood sample from the individual; stimulating the whole blood sample by incubating the latter with a quantity of phytohemagglutinin (PHA) at a temperature between 35° C. and 39° C. for a minimum of 3 to 3.5 hours; evaluating the level of interferon-gamma production induced by this incubation/stimulation, the evaluated level subsequently providing an indication of the individual's immune status.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

A method for detecting an immune cellular response including the steps of: (a) suctioning a defined amount of the sample by an automated suction/discharge device, (b) discharging this amount, using the device, into container R, containing, beforehand, at least one stimulant for secretion of the molecule by the at least one cell, or else not containing such a stimulant, (c) when the container does not contain the stimulant beforehand, introducing into container R the at least one secretion stimulant contained in container E, using the device, and (d) allowing the sample and stimulant to incubate, forming a mixture, by the at least one cell (i) in container R or (ii) in another container S after suctioning and discharge of the mixture using the device, and (e) detecting the immune cellular response, the detection of the immune cellular response indicates the presence of an immune cellular response specific for the stimulant.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

The invention concerns a method of assessing the risk of death of a patient, comprising the steps of: A1. Measuring a first value V1 reflecting the level of expression of CX3CR1 gene in a biological sample obtained from said patient, B1. Measuring a second value V2 reflecting the level of expression of CDK1 gene in a biological sample obtained from said patient.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p. ex. utilisation de bandes de papier indicateur

Produits et services

Chemical reagents and biological preparations for diagnosis, Not for medical or veterinary use; Reagents and culture media for the monitoring, detection, diagnosis and analysis of microorganisms in industrial, agri-food, cosmetic and pharmaceutical preparations and in the environment in which these preparations are produced, namely water, air and work surfaces. Reagents and culture media enabling the monitoring, detection, diagnosis and analysis of microorganisms for medical, pharmaceutical and veterinary purposes. Scientific apparatus and instruments for the diagnosis (not for medical purposes) and for the monitoring and detection of microorganisms in industrial, agri-food, cosmetic and pharmaceutical preparations and in the environment in which these preparations are produced, namely water, air and work surfaces; Petri dishes. Diagnostic apparatus and instruments for medical and veterinary use; Petri dishes For medical and veterinary purposes; Containers for the collection of medical and veterinary waste; Containers for the collection of Petri dishes contaminated with microorganisms. Disinfection, sanitisation, sterilisation and cleaning of Petri dishes and apparatus and instruments for the diagnosis of microorganisms; Providing of information, advice and assistance relating to the disinfection, sanitisation, sterilisation and cleaning of Petri dishes and of apparatus and instruments for the diagnosis of microorganisms. Collection and transport of waste, namely Collection and transport of Petri dishes and of apparatus and instruments for the diagnosis of microorganisms; Information and consultancy and advisory services Relating to the collection and transport of waste, namely Petri dishes and apparatus and instruments for the diagnosis of microorganisms. Sorting, recycling, treatment and processing of waste, namely Petri dishes and apparatus and instruments for the diagnosis of microorganisms; Information, consultancy and advisory services Relating to the sorting, recycling, treatment and processing of waste, namely namely Petri dishes and apparatus and instruments for the diagnosis of microorganisms.

Abrégé

A method for detecting target genomic sequences at predetermined positions in a sequenced genome of a microbial organism in the form of reads. The method comprises computing a local sequencing depth of the genome in a neighborhood of the position of a target genomic sequence, the computing including a) detecting in the reads a set of digital genomic sequences from at least one reference genome of the microbial organism, b) generating of third set of digital genomic sequences comprising reads and digital genomic sequences of the second set belonging to the neighborhood c) counting the number of copies of each digital genomic sequences of the third set of digital genomic sequences, and d) computing the local sequencing depth as being equal to the maximum of the counted numbers of copies.

Classes IPC  ?

• G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
• G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
• G16B 40/20 - Analyse de données supervisée

Abrégé

12344, are as defined in claim 1, including their salts. The invention concerns also a detection probe PR labelled with at least one molecule of a compound FC according to the invention, comprising an oligonucleotide covalently coupled on the reactive group RG of said compound FC, the methods and kits using them.

Classes IPC  ?

• C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

Abrégé

The present invention relates to a method for isolating viable microorganisms which are potentially present in a sample comprising 106 to 108 immune cells or progenitor cells thereof, the method comprising the following steps: - bringing the sample into contact with: • a lysing composition comprising o a lysis buffer comprising a non-ionic detergent at a concentration of between 0.004% and 0.050% of the reaction volume o and/or a lysis solution comprising a saponin at a concentration of between 0.03% and 4% of the reaction volume; • an endonuclease for digesting the nucleic acids released by the action of the lysing composition; • an endopeptidase acting at a pH of between 7 and 8; - separating the viable microorganisms which are potentially present in the sample by filtering the sample through a filter, the pores of which have a diameter of between 0.30 and 0.50 μm. The present invention also relates to the associated solid-phase cytometry detection method.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/22 - Test des conditions de stérilité
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
• C12N 1/06 - Lyse des micro-organismes

Abrégé

The present invention relates to in vitro or ex vivo methods and kits for determining the viral or bacterial nature of an infection on the basis of a biological sample of a patient by identifying the change in the level of expression of a plurality of biomarkers. In particular, the method includes the steps of (a) measuring the expression of at least one viral target gene and of at least one bacterial target gene chosen from among OLAH, FAM20A, IL1R2, MMP8, RETN and SLC1A2; (b) comparing the expressions measured in step (a) with reference expression values for these target genes; and (c) on the basis of the results of the comparison, concluding whether the infection is viral or bacterial in nature.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle
• C12Q 1/686 - Réaction en chaine par polymérase [PCR]

Produits et services

Culture media for detection and identification of pathogens in agri-food, pharmaceutical, cosmetic products and in the production environment of these products (water, air, work surfaces). Culture media for medical and veterinary diagnosis. Petri dishes.

Abrégé

Systems, methods, and apparatuses are provided for self-contained nucleic acid preparation, amplification, and analysis.

Classes IPC  ?

• B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques

Abrégé

CandidaC. aurisC. albicans, C. glabrata, C.tropicalis, C. parapsilosis and C. krusei.CandidaCandida genus; and - an α-glucosidase inducer and optionally an α-glucosidase repressor; - an acid phosphatase inducer and a phosphatase repressor; - an N-acetyl-β-glucosaminidase inducer; and - detecting any α-glucosidase, acid phosphatase and/or N-acetyl-β-glucosaminidase activities expressed by the yeasts; and - identifying the species to which the yeasts belong on the basis of the α-glucosidase, acid phosphatase and/or N-acetyl-β-glucosaminidase activities actually expressed by the yeasts.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/25 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des enzymes qui ne peuvent pas être classées dans les groupes
• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase

Abrégé

A system for extracting components from a biological sample, the system including at least one extraction platform, a magnetic extraction module including a magnetic portion and a securing portion for securing the module to the extraction platform, the magnetic portion including at least one magnet that is fixedly mounted relative to the securing portion, the extraction platform including a pipetting support that is configured to co-operate with a pipetting device, characterised in that the magnetic portion of the magnetic extraction module has at least one position of use in which the magnetic portion is fixed at least relative to the pipetting support.

Classes IPC  ?

• G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
• C12M 1/26 - Inoculateur ou échantillonneur
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet

Abrégé

A method for in vitro or ex vivo assessment of the risk of complications in a patient admitted to a healthcare facility includes measuring the viral load of at least one torque teno virus (TTV) in a biological sample of the patient, wherein the patient is not undergoing immunosuppressive treatment.

Classes IPC  ?

• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages

Produits et services

Computer software and program dedicated to microbiology laboratory management. Software as a Service (SaaS) dedicated to microbiology laboratory management.

Abrégé

An analysis card for analysing a biological sample by means of an in-vitro diagnostic instrument, the analysis card including a plurality of wells formed in a board, each well containing at least one reagent, the analysis card including a channel for conveying a liquid sample to the wells, characterised in that each well forms, in the board, an internal space defined by a lateral surface, the lateral surface including at least one wall, and in that each well has the at least one reagent deposited only on its lateral surface.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Produits et services

Culture media for the detection and identification of pathogens in food, pharmaceutical and cosmetic products and in the production environment of these products (water, air, work surfaces). culture media for use in the following fields: medical diagnosis and Veterinary diagnosis. Petri dishes.

Produits et services

Culture media for detection and identification of pathogens in agri-food, pharmaceutical, cosmetic products and in the production environment of these products (water, air, work surfaces). Culture media for medical and veterinary diagnosis. Petri dishes.

Abrégé

The invention relates to a method for characterising microorganisms which comprises: A. for each wavelength of a predetermined set of wavelengths comprising at least one wavelength, acquiring a holographic digital image, generating a focused image by computer means, each pixel of which image comprises an amplitude value and a phase value, and segmenting the focused image so as to extract portions corresponding to microorganisms; and B. characterising the microorganisms by computer means, according to the focused image portions. According to the invention, prior to the characterisation or prior to the segmentation or prior to the generation of the focused image, the method comprises correcting optical aberrations of the acquisition device by computer means, and the characterisation of the microorganisms comprises applying a digital model to these portions having as descriptors the amplitude and/or phase values of each wavelength of the predetermined set of wavelengths.

Classes IPC  ?

• G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques
• G03H 1/04 - Procédés ou appareils pour produire des hologrammes
• G03H 1/26 - Procédés ou appareils adaptés spécialement pour produire des hologrammes multiples ou pour en obtenir des images, p. ex. procédés pour l'holographie à plusieurs couleurs
• G01N 15/1433 - Traitement du signal utilisant la reconnaissance d’image
• G01N 15/1434 - Dispositions optiques
• G01N 15/10 - Recherche de particules individuelles
• G03H 1/08 - Procédés ou appareils pour produire des hologrammes pour faire des hologrammes synthétiques
• G06T 7/00 - Analyse d'image
• G06V 10/143 - Détection ou éclairage à des longueurs d’onde différentes
• G06V 10/22 - Prétraitement de l’image par la sélection d’une région spécifique contenant ou référençant une formeLocalisation ou traitement de régions spécifiques visant à guider la détection ou la reconnaissance
• G06V 10/24 - Alignement, centrage, détection de l’orientation ou correction de l’image
• G06V 10/26 - Segmentation de formes dans le champ d’imageDécoupage ou fusion d’éléments d’image visant à établir la région de motif, p. ex. techniques de regroupementDétection d’occlusion
• G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique

Produits et services

Computer software and programs for use in microbiology laboratory management. Software as a service (SaaS) for use in microbiology laboratory management.

Produits et services

Computer software and program dedicated to microbiology laboratory management. Software as a Service (SaaS) dedicated to microbiology laboratory management.

Abrégé

The invention relates to a method for identifying a microbial strain taking the form of a colony, comprising acquiring a set of at least three spectral channels of the colony contained in the visible and infrared spectrum; and making, by means of a computer, a prediction of the species depending on the acquired spectral channels. The three channels of said set that contribute the most to the performance of the prediction are selected from a first spectral band [730-780] nm and from a second spectral band [550-650] nm.

Classes IPC  ?

• G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
• G01J 3/02 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur Parties constitutives
• G01J 3/10 - Aménagements de sources lumineuses spécialement adaptées à la spectrométrie ou à la colorimétrie
• G01J 3/32 - Mesure de l'intensité des raies spectrales directement sur le spectre lui-même en étudiant des bandes d'un spectre successivement à l'aide d'un détecteur unique
• G01J 3/42 - Spectrométrie d'absorptionSpectrométrie à double faisceauSpectrométrie par scintillementSpectrométrie par réflexion
• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• G01N 21/359 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge proche
• G01J 3/12 - Production du spectreMonochromateurs

Abrégé

The present document relates to an optical device configured to measure fluorescence and absorbance in an immunoassay and in wet chemistry, comprising: - an illuminator channel (26) comprising at least one excitation source (28), - a detector channel (34) comprising at least one sensor (36), - a cuvette (130) containing a sample (132) between the illuminator channel (26) and the detector channel (34), - a mixer (38) of optical light between the illuminator channel (26) and the cuvette (130) and a beam splitter (40) between the cuvette (130) and the detector channel (34).

Classes IPC  ?

• G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
• G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné

Abrégé

The invention relates to a method for detecting colonies of microorganisms in a biological sample arranged in a solid culture medium, the method being implemented by a detection system comprising at least one incubator, an analysis unit, and at least one automated image capture system, the method comprising a first phase of detecting and counting objects, in the field of view of the image capture system, exhibiting growth, and a second phase applied only to those samples deemed to be negative in the first phase of the method, the second phase being based on anomaly detection applied to at least the last image acquired in the incubation sequence.

Classes IPC  ?

• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires

Abrégé

E. coliE. coliE. coli which is likely to be present in a sample comprising enterobacteria.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/10 - Entérobactéries
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

Escherichia ColiEscherichia Coli (STEC) which may be present in a sample comprising enterobacteria, comprising the following steps: - performing lysis of the sample, enabling lysis of the STECs in order to obtain a solution comprising the nucleic acids thereof; - bringing the solution of nucleic acids into contact with primers, making it possible to amplify at least the stx1 and/or stx2 gene or gene fragment; - if at least one of the stx1 and/or stx2 genes or gene fragments is amplified, part of the sample is deposited on an agar reaction medium comprising ■ at least one toxin inducer, ■ at least one agglutinating conjugate formed by at least one binding partner specific to the STX1 protein and/or at least one binding partner specific to the STX2 protein, which binding partner(s) is (are) coupled to a nanoparticle; - detecting and confirming the presence of at least one STEC by the appearance of a halo on the agar around the STEC.

Classes IPC  ?

• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/06 - Détermination quantitative
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

Disclosed is a method for digitally simulating a polymerase chain amplification of at least one target, comprising the simulation of a plurality of successive cycles of the amplification, each cycle comprising: a hybridization phase; an elongation phase; then a denaturation phase; wherein the hybridization phase comprises, for each cycle: obtaining, for the cycle, an initial value of a vector of concentrations of a plurality of nucleic acid molecules in the form of single strands; initializing a matrix of concentrations of duplexes formed by the hybridization of the plurality of nucleic acid molecules in the form of single strands; calculating the change in the matrix of concentrations during the hybridization phase by applying, to the matrix of concentrations, a matrix differential equation representing the kinetics of the duplex formation according to the concentrations of the plurality of nucleic acid molecules.

Classes IPC  ?

• G16B 5/30 - Modèles temporels dynamiques
• G16B 25/20 - Réaction en chaîne par polyméraseConception d’amorces ou de sondesOptimisation de la sonde

Abrégé

Disclosed is a method for digitally simulating a polymerase chain amplification of at least one target, comprising the simulation of a plurality of successive cycles of the amplification, each cycle comprising, sequentially: a hybridization phase; an elongation phase; then a denaturation phase; wherein, for each cycle: the hybridization phase comprises: obtaining, for the cycle, an initial value of a vector of concentrations of a plurality of nucleic acid molecules in the form of single strands; calculating a matrix of concentrations of partial duplexes formed by the hybridization of the plurality of nucleic acid molecules in the form of single strands; the denaturation phase comprises: multiplying a vector of the concentration of elongated duplexes resulting from the application of the elongation phase to the concentrations of duplexes, by an elongated duplex denaturation tensor.

Classes IPC  ?

• G16B 5/30 - Modèles temporels dynamiques
• G16B 25/20 - Réaction en chaîne par polyméraseConception d’amorces ou de sondesOptimisation de la sonde

Abrégé

A method for determining in vitro or ex vivo the immune status of an individual, preferably a patient, including a step of detecting and/or quantifying the expression of one or more HERV/MaLR sequences in a biological sample of the individual. Also relates to the tools for implementing the method and to the uses thereof.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The present invention relates to a method for predicting the susceptibility of a microbial strain to an antimicrobial agent, the method being characterized in that it comprises implementation, by data-processing means (4) of a client (2), of steps of: (a) obtaining a hyperspectral image between 390 nm and 900 nm representing at least one colony of said strain in a sample devoid of antimicrobial agent (22); (b) determining a spectrum of the colony based on pixels of said hyperspectral image corresponding to said colony, “test spectrum” below; (c) comparing said test spectrum with microbial classes of a database of predetermined data, “reference microbial class” below, said classes corresponding to a taxonomic level lower than species and being learnt using at least one hyperspectral spectrum of a microbial strain, the database containing, for each reference microbial class, the susceptibility to the microbial agent of the reference microbial class; (d) determining the susceptibility of the microbial strain to the microbial agent to be the susceptibility associated with the reference microbial class closest to the test hyperspectral spectrum.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires

Abrégé

The invention relates to a ready-to-use calibration composition for a mass spectrometer, comprising whole E. coli bacteria suspended in a liquid which is based on alcohol (s) and/or acetonitrile and is sanitizing, volatile and does not denature bacterial proteins.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 1/28 - Préparation d'échantillons pour l'analyse

Abrégé

The invention relates to a microbiological typing method, which comprises providing: a database of genetic profiles of microbial strains; and a phylogenetic tree of assignments of the genetic profiles to positions in the phylogenetic tree, and of frequencies of variation of the profiles in the tree. The typing of a microorganism comprises: measuring the genetic profile of the microorganism; determining a probability of variation of each genetic profile in the database with respect to the measured genetic profile, the probability of variation being calculated as a function of the frequencies of variation; and determining that the microorganism belongs to a taxon of the tree if at least the probability of variation for the taxon is greater than a threshold. According to the invention, the phylogenetic tree is constructed from a core genome of the microorganism species, and the predefined set of genetic markers is chosen from an accessory genome of the microorganism species.

Classes IPC  ?

• G16B 10/00 - TIC spécialement adaptées à la bio-informatique évolutive, p. ex. construction ou analyse d’arbre phylogénétique
• G16B 40/20 - Analyse de données supervisée
• G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
• G16B 20/40 - Génétique de populationDéséquilibre de liaison
• G16B 30/10 - Alignement de séquenceRecherche d’homologie

Abrégé

The invention relates to a microbiological typing method, which comprises providing a database of genetic profiles of microbial strains, a phylogenetic tree, assignments of the genetic profiles to positions in the phylogenetic tree, and frequencies of variation of the profiles in the tree. The typing of a microorganism comprises measuring the genetic profile of the microorganism, determining probabilities of variation of the genetic profiles belonging to the groups with respect to the measured genetic profile, the probabilities of variation being calculated as a function of the frequencies of variation at a predefined level of the phylogenetic tree and of the belonging of the microorganism to one of the microbial groups if an identification performance criterion is reached for the group, the criterion being reached if at least one probability of variation for the group is greater than a first predefined threshold.

Classes IPC  ?

• G16B 10/00 - TIC spécialement adaptées à la bio-informatique évolutive, p. ex. construction ou analyse d’arbre phylogénétique
• G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
• G16B 20/40 - Génétique de populationDéséquilibre de liaison
• G16B 30/10 - Alignement de séquenceRecherche d’homologie
• G16B 40/20 - Analyse de données supervisée

Produits et services

Chemical preparations for industry and research; chemical preparations for scientific use; chemical reagents and biological preparations for diagnosis, other than for medical use; reagents and culture media for the control, detection, diagnosis and analysis of contaminating microorganisms and substances in industrial, agri-food, cosmetic and pharmaceutical products; reagents and media enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics. Reagents and culture media for medical and veterinary diagnosis; laboratory reagents for use in clinical, medical or veterinary laboratories; chemical, biochemical and biological preparations for use in the medical and veterinary fields; reagents and culture media for medical and veterinary use enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics. Diagnostic apparatus and instruments, not for medical use; scientific analysis and diagnostic apparatus and instruments, other than for medical use; laboratory instruments; Scientific apparatus and instruments for the monitoring, detection, diagnosis and analysis of contaminating substances in industrial, agri-food, cosmetic, pharmaceutical and veterinary products; scientific apparatus and instruments enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics; software for analyzing, processing and interpreting medical and veterinary test results in the field of in vitro diagnosis. Apparatus and instruments for medical and veterinary diagnostic purposes; apparatus and instruments for medical and veterinary use enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics.

Abrégé

The present invention provides for the prediction or detection of antimicrobial drug resistance in a microorganism, particularly in a pathogenic microorganism, by determining the presence or absence of antimicrobial resistance markers (AMRs) in the microorganism. This allows for the rapid determination of whether a microorganism is resistant to one or more antimicrobial drugs. The microorganism can be obtained from a patient suffering or suspected of suffering from an infection by the microorganism, and once the determination is made, the patient can be given an antimicrobial drug to which the microorganism is not resistant.

Classes IPC  ?

• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
• G16B 20/00 - TIC spécialement adaptées à la génomique ou protéomique fonctionnelle, p. ex. corrélations génotype-phénotype
• G16B 50/20 - Intégration de données hétérogènes

Abrégé

A method for quantifying endotoxins in a biological sample with an analysis medium added to the field of view of an imager, the analysis medium including at least one analysis chamber and a plurality of reference chambers, including the steps of, for each of a plurality of measuring times of a measuring period: a) acquiring an image and determining light intensity valves in the reference and analysis chambers; b) determining a calibration relationship connecting the light intensity value and the concentration at this measuring time; c) determination of at least one endotoxin concentration in a biological sample from said calibration relationship and the intensity value in the analysis chamber at said measurement time; the method subsequently including the step of d) determining a temporal evolution of an endotoxin concentration in the biological sample over the course of the measuring period from the endotoxin concentration for a plurality of measurement times.

Classes IPC  ?

• G01N 33/92 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des lipides, p. ex. le cholestérol
• G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
• G01N 21/76 - ChimioluminescenceBioluminescence
• G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique

Abrégé

A method for determining, in vitro or ex vivo, the presence in a patient of an infection by a replicating respiratory virus, including a step i) of determining, in a test sample taken from the mouth or nose of said patient, the level of transcripts of at least one marker gene selected from the interferon-stimulated genes, referred to as ISGs; and associated kits.

Classes IPC  ?

• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
• C12Q 1/6851 - Amplification quantitative

Abrégé

The invention relates to a filtration device for use in solid-phase cytometry, said filtration device being configured to filter a biological sample likely to contain microorganisms and to allow its analysis, the filtration device comprising: a filtration membrane configured to filter the biological sample, the filtration membrane having an upper face and a lower face, characterized in that the filtration device further comprises at least: a coverslip arranged above the upper face of the filtration membrane, the coverslip being arranged so as to cover the entirety of the upper face of the membrane, an interstitial space formed between the coverslip and the upper face of the filtration membrane, the interstitial space being shaped to receive a fluid.

Classes IPC  ?

• G01N 1/40 - Concentration des échantillons
• G01N 15/06 - Recherche de la concentration des suspensions de particules

Abrégé

The invention relates to a method for determining the susceptibility of a strain of Mycobacterium tuberculosis to pyrazinamide, the method comprising the following steps: (i) determining the presence in the genome of this strain of at least one mutation in the rpoB gene between positions 761112 and 761182; and (ii) determining the sensitive or resistant nature of this strain depending on the presence or absence of the at least one mutation. The invention also relates to a kit comprising means for detecting at least one sequence chosen from among the sequences SEQ ID NO: 1 to 3 and to the use of this same kit for determining the susceptibility of a strain of Mycobacterium tuberculosis to pyrazinamide.

Classes IPC  ?

• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries

Produits et services

Chemical preparations for industry and research; chemical preparations for scientific use; chemical reagents and biological preparations for diagnosis, other than for medical use; reagents and culture media for the control, detection, diagnosis and analysis of contaminating microorganisms and substances in industrial, agri-food, cosmetic and pharmaceutical products; reagents and media enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics. Reagents and culture media for medical and veterinary diagnosis; laboratory reagents for use in clinical, medical or veterinary laboratories; chemical, biochemical and biological preparations for use in the medical and veterinary fields; reagents and culture media for medical and veterinary use enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics. Diagnostic apparatus and instruments, not for medical use; scientific analysis and diagnostic apparatus and instruments, other than for medical use; laboratory instruments; Scientific apparatus and instruments for the monitoring, detection, diagnosis and analysis of contaminating substances in industrial, agri-food, cosmetic, pharmaceutical and veterinary products; scientific apparatus and instruments enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics; software for analyzing, processing and interpreting medical and veterinary test results in the field of in vitro diagnosis. Apparatus and instruments for medical and veterinary diagnostic purposes; apparatus and instruments for medical and veterinary use enabling the control, diagnosis and analysis of contaminating microorganisms and substances for detecting biological threats and monitoring epidemics and pandemics.

Produits et services

Chemicals used in industry, Chemical preparations for research; Chemical preparations for scientific purposes; Chemical diagnostic reagents, Biological diagnostic preparations, not for medical purposes; Reagents and Growing media, for use in the following fields: Monitoring, detection, diagnosis and analysis of microorganisms and contaminants in industrial goods, agri-foodstuffs, cosmetics and pharmaceuticals; Reagents and media for monitoring, diagnosing and analysing microorganisms and contaminants, for use in the following fields: Detection of biological threats and surveillance of epidemics and pandemics. Reagents and culture media, for use in the following fields: medical diagnosis and Veterinary diagnosis; Laboratory reagents for clinical, medical or veterinary laboratories; Chemical, biochemical and biological preparations, for use in the following fields: Medicine and Veterinary medicine; Reagents and media enabling the monitoring, diagnosis and analysis of microorganisms and contaminants, For medical purposes and Veterinary use, for use in the following fields: Detection of biological threats and surveillance of epidemics and pandemics. Diagnostic apparatus and instruments, not for medical purposes; Scientific analysis and diagnostic apparatus and instruments, Not for medical purposes; Laboratory instruments; Scientific apparatus and instruments, for use in the following fields: Monitoring, detection, diagnosis and analysis of contaminants in industrial goods, agri-foodstuffs, cosmetics, pharmaceuticals and veterinary goods; Scientific apparatus and instruments for monitoring, diagnosing and analysing microorganisms and contaminants, for use in the following fields: Detection of biological threats and surveillance of epidemics and pandemics; Software for analysis, processing and interpretation of medical and veterinary test results in the field of in vitro diagnosis. Instruments and apparatus for medical and veterinary diagnosis; Apparatus and instruments for monitoring, diagnosing and analysing microorganisms and contaminants, For medical and veterinary purposes, for use in the following fields: Detection of biological threats and surveillance of epidemics and pandemics.

Abrégé

The invention relates to a method of determining an infection of a patient with at least one microorganism, particularly a bacterial microorganism, potentially resistant to antimicrobial drug treatment, a method of selecting a treatment of a patient suffering from an infection with at least one microorganism, particularly bacterial microorganism, and a method of determining structural changes of the genome of the microorganism, particularly bacterial microorganism, comprising at least one gene, as well as Computer program products used in these methods.

Classes IPC  ?

• G16B 15/00 - TIC spécialement adaptées à l’analyse de structures moléculaires bidimensionnelles ou tridimensionnelles, p. ex. relations structurelles ou fonctionnelles ou alignement de structures
• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
• G16B 20/00 - TIC spécialement adaptées à la génomique ou protéomique fonctionnelle, p. ex. corrélations génotype-phénotype
• G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
• G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
• G16B 30/10 - Alignement de séquenceRecherche d’homologie
• G16B 30/20 - Assemblage de séquences
• G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs

Abrégé

The invention relates to a method of determining an antimicrobial drug resistance profile for a microorganism, wherein nucleic acid sequences of the microorganism are analyzed for at least two genetic variations of the nucleic acid sequences comprising at least one genetic variation in a chromosome and at least one genetic variation in at least one plasmid, as well as a, e.g. diagnostic, method of determining an infection of a patient with a microorganism potentially resistant to antimicrobial drug treatment and a method of selecting a treatment of a patient suffering from an infection with a potentially resistant microorganism, wherein the data of the antimicrobial drug resistance profile are applied.

Classes IPC  ?

• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
• G16B 20/00 - TIC spécialement adaptées à la génomique ou protéomique fonctionnelle, p. ex. corrélations génotype-phénotype
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

The invention relates to a method of determining, from an assayed sample or a population of assayed samples previously drawn from patients, a transcriptomic score (TScore) suitable for assessing a risk of adverse clinical outcome for patients in a clinical setting, said method involving, amongst other steps, the measurement of gene expression values on a patient sample or a population of samples previously obtained from patients for at least two distinct genes selected among a predetermined set of genes, and the determination of a transcriptomic score where the genes are assigned or not assigned a point. The method can be computer-implemented. The genes of the predetermined set of genes can be at least two genes selected among: ADGRE3, ARL14EP, BPGM, C3AR1, CCNB1IP1, CD177, CD274, CD3D, CD74, CIITA, CTLA4, CX3CR1, GNLY, IFNgamma, IL10, IL1R2, IL1RN, IL7R, IP10/CXCL10, MDC1, OAS2, S100A9, TAP2, TDRD9, TNF and ZAP70. The method can be implemented on assayed biological sample(s) drawn from patient(s) which have been admitted in a reanimation unit, an intensive or continuing care unit. The invention also relates to a method to classify a sample previously drawn from a patient, in a group reflecting a risk of adverse clinical outcome in a clinical setting, or to identify a patient at risk of adverse clinical outcome in a clinical setting, as well as an in vitro or ex vivo method of screening whether a drug has the capacity to alleviate an adverse clinical outcome in a patient. The invention also relates to computer means for implementing the invention, and the use of a kit for carrying out a method of the invention.

Classes IPC  ?

• C12Q 1/12 - Bactéries réduisant les nitrates en nitrites
• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The present invention relates to an improved immuno-molecular assay, for example a Proximity Extension Assay protocol or a Proximity Ligation Assay (PLA) protocol, which is more compatible with the assay durations that are expected in the context of point-of-care diagnostics. In particular, the time needed for performing the Proximity Extension Assay protocol of the invention is reduced by more than 13-folds as compared to classical Proximity Extension Assay protocols, without significantly affecting the performance of the assay for protein detection. Thus, the method of the invention provides a more rapid and simpler procedure to screen and diagnose diseases in a non-invasive way. The use of such a method in an integrated system is an exciting and expected improvement in clinical diagnostics for the detection of biomarkers in human samples.

Classes IPC  ?

• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 33/542 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p. ex. extinction de fluorescence
• C12Q 1/6804 - Analyse d’acides nucléiques utilisant des immunogènes

Abrégé

An in vitro or ex vivo method for determining the risk of incidence of a healthcare-associated infection in a patient, including a step of measuring the expression of at least one gene encoding a pro-inflammatory cytokine receptor located on chromosome 2 in the region 2q11-2q12, in a biological sample from the patient.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• C12Q 1/6851 - Amplification quantitative

Abrégé

The invention relates to a method for detecting the presence of a signal from a polymer in spectra obtained by mass spectrometry of biological samples, the method comprising a step (101) of determining a set of at least one parameter, referred to as a descriptor, of the presence of the polymer, a step (103) of assigning a score to each value of each descriptor, and a step (105) of classifying the scores into a class of positive spectra containing no polymer and a class of negative spectra containing the polymer.

Classes IPC  ?

• G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase
• G16C 20/00 - Chémo-informatique, c.-à-d. TIC spécialement adaptées au maniement des données physicochimiques ou structurelles des particules, des éléments, des composés ou des mélanges chimiques
• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique

Abrégé

It is disclosed a method for performing fluorescence measurement on a sample, comprising: Illuminating the sample using a light source, acquiring at least one fluorescence image of the illuminated sample, and processing the fluorescence image to determine a fluorescence intensity of the sample, characterized in that processing the fluorescence image to determine a fluorescence intensity of the sample comprises: extracting, from the fluorescence image, a region of interest (ROI) free from artefacts, by application of a trained model, and determining the fluorescence intensity of the sample from the extracted region of interest.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/03 - Détails de structure des cuvettes

Abrégé

The disclosure relates to a sample collection device (1, 100) comprising a support (10, 110) arranged to collect and release microbiological fluids, the sample collection device further comprising a head (7, 107), said head (7, 107) being configured to cooperate with a spout (6) of an analysis device (2) in such a way that the cooperation between the head (7, 107) and the spout (6) causes microbiological fluid to be released inside the analysis device (2).

Classes IPC  ?

• A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge

Abrégé

12122 comprises a Lys tag and a second peptide moiety comprises a His tag.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12Q 1/6851 - Amplification quantitative

Produits et services

Chemical preparations for industry and research; chemical reagents and biological preparations for diagnosis, other than for medical use; chemical preparations for scientific use; reagents and culture media for controlling, detecting, diagnosing and analyzing contaminating substances in industrial, agri-food, cosmetic, pharmaceutical and environmental products. Reagents and culture media for medical, pharmaceutical and veterinary diagnosis; laboratory reagents for clinical or medical laboratories; biological preparations for medical or veterinary use.

Abrégé

The invention concerns compounds of formula (I) and their salts, as defined into claim 1 and their uses, in particular in PCR applications.

Classes IPC  ?

• C07D 417/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme

Abrégé

The invention relates to the field of molecular biology and more particularly that of clinical and industrial microbiology. More specifically, the present invention relates to a culture medium for detecting microorganisms, comprising, as a gelling agent, a mixture of agar and kappa-carrageenan.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/06 - Détermination quantitative
• C12Q 1/08 - Détermination quantitative utilisant des milieux polyvalents

Abrégé

The present invention relates to a method of determining an infection of a patient with at least one microorganism, particularly a bacterial microorganism, potentially resistant to antimicrobial drug treatment, a method of selecting a treatment of a patient suffering from an infection with at least one microorganism, particularly bacterial microorganism, and a method of determining an antimicrobial drug, e.g. antibiotic, resistance profile for at least one microorganism, particularly bacterial microorganism, as well as computer program products used in these methods.

Classes IPC  ?

• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
• C12Q 1/6869 - Méthodes de séquençage

Abrégé

A method for quantifying at least one microorganism group via at least one mass spectrometry analysis. The method includes at least one separation and fragmentation step. The method moreover includes a step that involves measuring the amount of at least one representative peptide or at least one protein representing the microorganism group. The at least one representative peptide or the at least one protein is obtained after the at least one separation and fragmentation step and serves as a quantification marker(s). The amount of the quantification marker(s) is directly correlatable to the amount of the at least one microorganism group.

Classes IPC  ?

• C12Q 1/06 - Détermination quantitative
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A system for diluting a sample of biological material, including a fluid circuit, wherein the fluid circuit includes at least: a first container configured to contain a sample of biological material containing a biological material to be diluted, the sample being a fluid; a second container configured to contain a first dilution fluid; and at least one first metering member for metering a predetermined volume of fluid, including a first wall and a second wall, the first metering member including a metering zone configured to change at least from an initial state in which the first wall and the second wall are in contact with one another to an operating state in which the first wall and the second wall are separated from one another.

Classes IPC  ?

• G01N 1/38 - Dilution, dispersion ou mélange des échantillons
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes

Abrégé

Systems, methods, and apparatuses are provided for self-contained nucleic acid preparation, amplification, and analysis.

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
• B01L 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
• C12Q 1/6844 - Réactions d’amplification d’acides nucléiques

Abrégé

An analysis plate configured to allow a characterization of microorganisms by mass spectrometry, wherein the analysis plate includes at least one analysis zone configured for a biological sample containing a population of at least one microorganism, wherein all or part of the analysis zone is made of a porous material, the analysis zone including at least one antimicrobial agent.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

Abrégé

Methods, sample vessels, and instruments are provided for determining susceptibility of a bacterium to one or more classes of antibiotics.

Classes IPC  ?

• C12N 1/36 - Adaptation ou atténuation de cellules
• C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
• C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle
• C12Q 1/6851 - Amplification quantitative
• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
• G16B 25/10 - Profilage de l’expression de gènes ou de protéinesEstimation ou normalisation de ratio d’expression
• C12N 1/20 - BactériesLeurs milieux de culture
• G01N 33/94 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des narcotiques

Abrégé

Detection method for sample presence and device associated The invention relates to a detection method of liquid presence inside a well of a transparent or translucent support intended for analysis performed in a device for in vitro detection and/or quantification, the presence of liquid being assessed on the basis of an index of visible pattern likelihood representative of the probability of a pattern to be legible as expected in the field of view of an imager. Said invention allows preventing assay execution without sample and can be applied without wasting sample or sample well support in case of the sample well is not filled by the user. Moreover, this method allows a precise detection of the samples that are transparent or translucent, with low reflectance.

Classes IPC  ?

• G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
• G06T 7/00 - Analyse d'image
• G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
• G06T 7/90 - Détermination de caractéristiques de couleur

Abrégé

The present invention relates to a method for in vitro or ex vivo detection of an immunocompromised status in a subject, comprising quantifying, in a biological sample of said subject, the expression of at least 2 target genes selected from the group consisting of TAP2, C3AR1, CD177 and IL1R2, and identifying whether or not a variation in their expression is present as compared to a reference value. The invention also relates to tools for implementing said method, and to uses thereof.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The present invention relates to in vitro or ex vivo methods and kits for determining the viral or bacterial nature of an infection on the basis of a biological sample of a patient by identifying the change in the level of expression of a plurality of biomarkers. In particular, the method comprises the steps of (a) measuring the expression of at least one viral target gene and of at least one bacterial target gene chosen from among OLAH, FAM20A, IL1R2, MMP8, RETN and SLC1A2; (b) comparing the expressions measured in step (a) with reference expression values for these target genes; and (c) on the basis of the results of the comparison, concluding whether the infection is viral or bacterial in nature .

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

A method of analyzing a biological sample including biological agents and disposed in an analysis receptacle in a field of view of a holographic imaging system defining an acquisition focal plane, including, for each of a plurality of measurement times: acquiring a plurality of holographic images of the biological sample at different respective positions of the acquisition focal plane, and, from each acquired holographic image, determining a value of a biomass parameter representative of the quantity of biological agents at the position of the acquisition focal plane, the method including constructing a distribution indicator from values of the biomass parameter at the same measurement time for a plurality of positions of the acquisition focal plane, and providing, among the analysis results, a representation of the distribution of the biomass of biological agents, derived from at least one distribution indicator at a measurement time.

Classes IPC  ?

• G01N 21/45 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant des méthodes interférométriquesRéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant les méthodes de Schlieren
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables

Abrégé

A method for classifying at least one input image representing a target particle in a sample, involves implementing, by data processing of a client, steps of: (b) extracting the characteristic map of the target particle by a convolutional neural network pre-trained on a base of public images; (c) classifying the input image according to the extracted characteristic map.

Classes IPC  ?

• G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
• G06T 7/10 - DécoupageDétection de bords
• G06V 10/24 - Alignement, centrage, détection de l’orientation ou correction de l’image
• G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
• G06V 10/774 - Génération d'ensembles de motifs de formationTraitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source méthodes de Bootstrap, p. ex. "bagging” ou “boosting”

Abrégé

The invention relates to a method for characterising microorganisms present in a biological sample, the method comprising acquiring a live holographic digital image of the sample, generating a focused image by using a digital model for reconstructing the focused image and characterising the bacteria on the basis of the focused image. According to the invention, prior to the holographic image being acquired, a plurality of calibration objects are provided in the acquisition field of view, which objects have a previously characterised dimension and refractive index and a shape chosen so that the interference patterns of the objects can be calculated using an image forming model for incorporating optical aberrations of the acquisition device. Prior to the focused image being computer generated, the optical aberrations are qualified according to the interference patterns of the objects and the calculated interference patterns and the digital model for reconstructing the focused image incorporates the quantified optical aberrations.

Classes IPC  ?

• G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques
• G03H 1/04 - Procédés ou appareils pour produire des hologrammes
• G03H 1/08 - Procédés ou appareils pour produire des hologrammes pour faire des hologrammes synthétiques
• G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
• G01N 15/10 - Recherche de particules individuelles
• G06T 7/00 - Analyse d'image
• G06V 10/24 - Alignement, centrage, détection de l’orientation ou correction de l’image
• G06T 5/00 - Amélioration ou restauration d'image
• G02B 21/00 - Microscopes

Abrégé

The subject matter is a method for determining the proliferation capacity of T lymphocytes in a subject, the method including the following steps: a) measuring the load of torque teno virus from a biological sample of the subject; and b) determining the proliferative capacity of the T lymphocytes based on the viral load measured in a).

Classes IPC  ?

• C12Q 1/6881 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour le typage de tissu ou de cellule, p. ex. sondes d’antigène leucocytaire humain [HLA]
• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages

Abrégé

in vitroex vivoex vivo method for determining the risk of death for a subject infected with a respiratory virus, said method comprising the steps of measuring, in a biological sample from said subject, the expression level of the OAS2 gene, and comparing the expression level thus measured or a value derived from this amount to a predetermined reference value. The method thus makes it possible to conclude that there is an increased risk of death for the subject when a sub-expression of the OAS2 gene is statistically demonstrated from the biological sample. Advantageously, the measurement of the expression level of OAS2 can be supplemented by a measurement of one or more additional genes such as C3AR1, CD177, ADGRE3, CIITA, IL-10, IL1R2, CD74, TDRD9 and combinations thereof. Kits for measuring the expression of OAS2 and optionally one or more additional genes are also disclosed.

Classes IPC  ?

• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages

Abrégé

The invention relates to an in vitro or ex vivo method for determining the risk of death in a subject infected with a respiratory virus, for example SARS-CoV-2, comprising a measurement, in a biological sample of said subject, of the level of expression of the CD74 gene; the invention also relates to associated kits.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

The invention relates to an in vitro or ex vivo determination method for determining the risk of death of a patient infected by a respiratory virus, said method comprising the steps of measuring, in a biological sample from said patient, the expression level of the ADGRE3 gene, and of comparing the expression level thus measured or a value derived from this quantity with a predetermined reference value. The method thus makes it possible to conclude that there is an increased risk of death of the patient when an underexpression of the ADGRE3 gene is statistically demonstrated from the biological sample. Advantageously, the measurement of the expression level of ADGRE3 can be supplemented by the measurement of one or more additional genes such as C3AR1, CD177, OAS2, CIITA, IL-10, IL1R2, CD74, TDRD9 and combinations thereof. The invention also relates to kits for measuring the expression of ADGRE3 and optionally of one or more additional genes.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages

Abrégé

The present invention relates to a method for quickly determining the immune status of an individual. The method comprises the following steps: taking a volume of a whole blood sample from the individual; stimulating the whole blood sample by incubating the latter with a quantity of phytohemagglutinin (PHA) at a temperature between 35°C and 39°C for a minimum of 3 to 3.5 hours; evaluating the level of interferon-gamma production induced by this incubation/stimulation, the evaluated level subsequently providing an indication of the individual's immune status.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The invention relates to a method for manufacturing a biological analysis card (1) comprising: - a step a) of providing a base (2) formed of: - at least two films (3) placed one on top of the other; - a receiving space (4) formed between the two films (3); - ducts (5) leading to the receiving space (4); - a step b) of placing a plate (9) in the receiving space (4), the plate (9) comprising: - a first face (10a) and a second face connected by an edge (11) having a profile; - a plurality of wells (12) opening onto at least the first face (10a) or the second face; - a plurality of channels (13) fluidly connecting the wells (12); - a welding step c) for welding the two films (3) in the receiving space (4) to the plate (9) and a film (3) to segments of the edge (11) of the plate (9) by applying a heating block to the film (3) against the edge (11) on the side of the first face (10a).

Classes IPC  ?

• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique

Produits et services

Chemicals used in industry, Chemical preparations for research; Chemical diagnostic reagents, Biological diagnostic preparations, not for medical purposes; Chemical preparations for scientific purposes; Reagents and Environments, For the following purposes: Checking, detecting, diagnosing, and Analysis, Relating to contaminants in industrial, agri-food, cosmetic, pharmaceutical and environmental products. Reagents and media for medical, pharmaceutical and veterinary diagnosis; Laboratory reagents for immunological analysis for use by clinical or medical laboratories; Biological preparations for medical or veterinary purposes.

Produits et services

Chemical preparations for industry and scientific research; chemical reagents and biological preparations for scientific diagnosis, other than for medical use; chemical preparations for scientific use; reagents and cell culture media for controlling, detecting, diagnosing and analyzing contaminating substances in industrial, agri-food, cosmetic, pharmaceutical and environmental products, not for medical use Reagents and cell culture media for medical, pharmaceutical and veterinary diagnosis; laboratory reagents for clinical or medical laboratories; biological preparations for diagnosis of disease or illnesses for medical or veterinary use

Abrégé

A digital holographic imaging technique, includes iterative steps of: a) through back-propagation to the object coordinate of a hologram field comprising a spatial distribution of amplitude corresponding to the spatial distribution of intensity of the hologram and a spatial distribution of phase, determining an object field involving a spatial distribution of absorption and of phase shift of the imaged object, b) thresholding the values of the spatial distribution of absorption and of phase shift by decreasing the values to below a respective threshold, the thresholds decreasing in each iteration, c) through repropagation of the object field to the hologram coordinate, determining a modified hologram field comprising a modified spatial distribution of amplitude and a modified spatial distribution of phase, d) replacing the spatial distribution of phase of the hologram field with the modified spatial distribution of phase, the spatial distribution of phase shift and of absorption of the imaged object being those of the object field of the last iteration.

Classes IPC  ?

• G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques

Abrégé

A method for classifying at least one input image containing a target particle in a sample, involves implementing, via data-processing of a client, steps of: (b) extracting a vector of characteristics of the target particle, the characteristics being numerical coefficients each associated with one elementary image of a set of elementary images each representing a reference particle, such that a linear combination of the elementary images weighted by the coefficients approximates the representation of the target particle in the input image; (c) classifying the input image depending on the extracted vector of characteristics.

Classes IPC  ?

• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G06V 10/774 - Génération d'ensembles de motifs de formationTraitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source méthodes de Bootstrap, p. ex. "bagging” ou “boosting”

Abrégé

A method for classifying at least one input image representing a target particle in a sample involves implementing, by data processing a client, steps of: (B) extracting a characteristic map of the target particle from the input image; (c) reducing the number of variables in the extracted characteristic map, using the t-SNE algorithm; (d) classifying, unsupervised, the input image based on the characteristic map having a reduced number of variables.

Classes IPC  ?

• G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
• G06T 7/11 - Découpage basé sur les zones
• G06V 10/24 - Alignement, centrage, détection de l’orientation ou correction de l’image
• G06V 10/771 - Sélection de caractéristiques, p. ex. sélection des caractéristiques représentatives à partir d’un espace multidimensionnel de caractéristiques
• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires

Abrégé

A method for classifying a sequence of input images representing a target particle in a sample over time, includes the following steps performed by the data processing of a client, namely: (b) concatenation of the input images in the sequence as a three-dimensional stack; (c) direct classification of the three-dimensional stack using a convolutional neural network, CNN

Classes IPC  ?

• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
• G06V 10/77 - Traitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source

Abrégé

The invention relates to a gelled reaction medium for the detection, identification, enumeration and/or isolation of at least one target microorganism in a sample that may contain same, comprising at least one binding partner specific to a component of a target microorganism or of a component derived from said microorganism, coupled to at least one nanoparticle to form at least one binding conjugate.

Classes IPC  ?

• C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
• C12Q 1/10 - Entérobactéries
• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet

Abrégé

Systems and methods for determining a topology for a multi-path connection based on one or more application-level wherein, a method performed by a master topology function includes receiving a request for a topology for a multi-path connection that satisfies an application-level requirement(s) of a particular application and determining a topology for the multi-path connection based on the application-level requirement(s). The topology includes two or more links from a source wireless node to a target wireless communication device and at least one of the two or more links is a multi-hop link from the source wireless node to the target wireless communication device via one or more additional wireless communication devices that operate as relays. The method further includes configuring the source wireless node, the target wireless communication device, and the one or more additional wireless communication devices in accordance with the determined topology.

Classes IPC  ?

• C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
• G01N 21/59 - Transmissivité
• G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques

Abrégé

in vitro in vitro method for determining whether a newborn patient has late-onset neonatal sepsis, which comprises determining the PTX-3 protein concentration in a biological sample previously obtained from said patient.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The present invention concerns reagents for the reversible protection of biological molecules. It relates in particular to compounds derived from azaisatoic anhydride and their uses for the protection of biological molecules, particularly enzymes, in order to block their activity. The invention also relates to the biological molecules protected in this manner and to the methods for making use of these reagents.

Classes IPC  ?

• C07D 498/04 - Systèmes condensés en ortho
• C12Q 1/6869 - Méthodes de séquençage

Abrégé

A method for detecting target genomic sequences at predetermined positions in a sequenced genome of a microbial organism in the form of reads. The method comprises computing a local sequencing depth of the genome in a neighborhood of the position of a target genomic sequence, said computing comprising the steps of a) detecting in the reads a set of digital genomic sequences from at least one reference genome of the microbial organism, b) generating of third set of digital genomic sequences comprising reads and digital genomic sequences of the second set belonging to the neighborhood c) counting the number of copies of each digital genomic sequences of the third set of digital genomic sequences, and d) computing the local sequencing depth as being equal to the maximum of the counted numbers of copies.

Classes IPC  ?

• G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides

Abrégé

An in vitro or ex vivo method for determining the risk of complication in a patient, including a step of measuring the expression of C3AR1 in a biological sample from the patient.

Classes IPC  ?

• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries

Produits et services

Chemical preparations for industry and research; chemical reagents and biological preparations for diagnosis, other than for medical use; chemical preparations for scientific use; reagents and culture media for controlling, detecting, diagnosing and analyzing contaminating substances in industrial, agri-food, cosmetic, pharmaceutical and environmental products. Reagents and cell culture media for medical, pharmaceutical and veterinary diagnosis; diagnostic reagents for immunological analysis for use in clinical or medical laboratories; biological preparations for medical or veterinary use.

Abrégé

A method for analysing a biological sample by means of an analysis instrument, the sample including biological agents and being arranged in an analysis receptacle in view of a holographic imaging system, the method including: acquiring a holographic image of the sample, the holographic image associating an intensity value with each pixel, determining, from the image acquired, an image mask which associates an active or inactive state with each pixel in accordance with the intensity values so that an inactive state is associated with pixels which correspond to artefacts caused by elements present in the field of view other than biological agents, determining a value of at least one biomass parameter which represents the quantitative spatial distribution of biological agents in the field of view, using only the pixels of the holographic image having an active state, and supplying the value of the biomass parameter from the analysis results.

Classes IPC  ?

• G01N 21/45 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant des méthodes interférométriquesRéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant les méthodes de Schlieren
• G01N 15/1429 - Traitement du signal
• G01N 15/1433 - Traitement du signal utilisant la reconnaissance d’image
• G01N 15/1434 - Dispositions optiques

Abrégé

The invention relates to an in vitro or ex vivo method for determining the risk of incidence of a care-related infection in a patient, including a step of measuring the expression of CIITA in a biological sample from said patient.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

in vitro in vitroin vitro methods and kit for predicting the risk of developing Post-Chikungunya Chronic Inflammatory Joint Disease (pCHIKV-CIJD) in a subject. The method comprises a step of evaluating the expression of one or more biomarkers in a biological sample obtained from said subject, for example a blood sample, wherein said one or more biomarkers are selected among specific long non-coding RNAs, and wherein a higher expression than control expression value indicates a risk of developing pCHIKV-CIJD.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

An in vitro or ex vivo method for determining the risk of incidence of a care-related infection includes a step of measuring the expression of CD177 in a biological sample from said patient.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

A focus adjustment method for acquiring an image of a surface of interest of a sample by a holographic imager includes the steps of: placing the sample including at least one reference object having a known shape and described by characterising parameters having at least position parameters acquiring an image and determining the position of the reference object with respect to the acquisition plane, by applying a light diffraction model involving the spatial parameters of the reference object estimated by approximating the appearance of the reference object in the holographic image acquired, and determining the position of the surface of interest with respect to the acquisition plane from a position of the reference object and focus adjustment of the image acquisition.

Classes IPC  ?

• G03H 1/04 - Procédés ou appareils pour produire des hologrammes
• G03H 1/02 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques Détails
• G03H 1/08 - Procédés ou appareils pour produire des hologrammes pour faire des hologrammes synthétiques
• G03H 1/00 - Procédés ou appareils holographiques utilisant la lumière, les infrarouges ou les ultraviolets pour obtenir des hologrammes ou pour en obtenir une imageLeurs détails spécifiques

Abrégé

The invention relates to a system for extracting components from a biological sample, the system comprising at least one extraction platform (101), a magnetic extraction module (1) comprising a magnetic portion (2) and a securing portion (S) for securing the module (1) to the extraction platform (101), the magnetic portion (2) comprising at least one magnet (4) that is fixedly mounted relative to the securing portion (S), the extraction platform (101) comprising a pipetting support (103) that is configured to co-operate with a pipetting device, characterised in that the magnetic portion of the magnetic extraction module has at least one position of use in which the magnetic portion is fixed at least relative to the pipetting support (103).

Classes IPC  ?

• G01N 1/34 - PurificationNettoyage
• G01N 1/40 - Concentration des échantillons
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
• B03C 1/01 - Prétraitement spécialement adapté à la séparation magnétique par addition d'agents magnétiques
• B03C 1/033 - Éléments constitutifsOpérations auxiliaires caractérisés par le circuit magnétique
• B03C 1/28 - Bouchons et jauges magnétiques
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
• G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
• B03C 1/30 - Combinaisons avec d'autres dispositifs, non prévues ailleurs
• C12M 1/26 - Inoculateur ou échantillonneur

Produits et services

Chemical products for use in research and industry, namely, reagents for non-medical purposes used in microbiological analyses, culture media for research, monitoring, detection and diagnosis of pathogens and contaminants

Produits et services

Chemicals used in industry, Chemical preparations for research; Chemical diagnostic reagents, Biological diagnostic preparations, not for medical purposes; Chemical preparations for scientific purposes; Reagents and Environments, For the following purposes: Checking, detecting, diagnosing, and Analysis, Relating to contaminants in industrial, agri-food, cosmetic, pharmaceutical and environmental products. Reagents and media for medical, pharmaceutical and veterinary diagnosis; Laboratory reagents for immunological analysis for use by clinical or medical laboratories; Biological preparations for medical or veterinary purposes.