Abrégé

The present invention relates to a computer-implemented method for preparing multiple dosage forms with personalised composition, comprising the following steps: (i) a control unit generates an input protocol of a personalised composition of a multiple dosage form, containing information about the type and amount of individual active substances, the type of cartridge, and the type and number of capsules; (ii) a cartridge of the required type according to the input protocol, labelled with a specific machine-readable code, is placed in the automatic transport system; (iii) at least two different types of sub-units are placed into at least two dosing stations, the sub-unit having sizes in the range of from 0.1 to 4 mm, and containing a different active ingredient and/or different amounts of the same active ingredient and/or having coatings with different solubility and/or possibly containing different pharmaceutical excipients according to the input protocol; (iv) a pre-defined number of capsule bodies is placed in the cartridge placed in an automatic transport system; (v) the automatic transport system transports the cartridge with capsules to the first dosing station, which doses a pre-defined number of the first sub-units into the capsule bodies placed in the cartridge; (vi) the automatic transport system transports the cartridge with capsules to the next dosing station, which doses a pre-defined number of the next sub-units into the capsule bodies placed in the cartridge; and this step is repeated according to the input protocol until the capsules are filled with all of the pre-defined types of sub-units; (vii) the capsules are closed with caps; (viii) the quality control of capsules and discarding of the non-compliant ones; (ix) packaging and labelling with a batch number. The present invention relates to a computer-implemented method for preparing multiple dosage forms with personalised composition, comprising the following steps: (i) a control unit generates an input protocol of a personalised composition of a multiple dosage form, containing information about the type and amount of individual active substances, the type of cartridge, and the type and number of capsules; (ii) a cartridge of the required type according to the input protocol, labelled with a specific machine-readable code, is placed in the automatic transport system; (iii) at least two different types of sub-units are placed into at least two dosing stations, the sub-unit having sizes in the range of from 0.1 to 4 mm, and containing a different active ingredient and/or different amounts of the same active ingredient and/or having coatings with different solubility and/or possibly containing different pharmaceutical excipients according to the input protocol; (iv) a pre-defined number of capsule bodies is placed in the cartridge placed in an automatic transport system; (v) the automatic transport system transports the cartridge with capsules to the first dosing station, which doses a pre-defined number of the first sub-units into the capsule bodies placed in the cartridge; (vi) the automatic transport system transports the cartridge with capsules to the next dosing station, which doses a pre-defined number of the next sub-units into the capsule bodies placed in the cartridge; and this step is repeated according to the input protocol until the capsules are filled with all of the pre-defined types of sub-units; (vii) the capsules are closed with caps; (viii) the quality control of capsules and discarding of the non-compliant ones; (ix) packaging and labelling with a batch number. The present invention further relates to a device for carrying out this method.

Classes IPC  ?

• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• G05B 19/418 - Commande totale d'usine, c.-à-d. commande centralisée de plusieurs machines, p. ex. commande numérique directe ou distribuée [DNC], systèmes d'ateliers flexibles [FMS], systèmes de fabrication intégrés [IMS], productique [CIM]

Abrégé

The present invention relates to a bipolar plate comprising a metal plate and at least one coating layer disposed on the metal plate, wherein the coating layer comprises a cured coating composition comprising: a) a matrix comprising at least one polymeric resin; and b) a plurality of conductive particles dispersed within the matrix; wherein a number of the conductive particles are arranged in the matrix so as to form a plurality of aligned particle assemblies constituting electrically conductive pathways extending across the thickness of the coating layer.

Classes IPC  ?

• H01M 8/0206 - Métaux ou alliages
• H01M 8/0226 - Composites sous forme de mélanges
• H01M 8/0228 - Composites sous forme de produits en couches ou enrobés

Abrégé

The present invention relates to a method for electrochemical synthesis of λ 53222, wherein R is independently selected from the group comprising (C1 to C10)alkyl, linear methoxy-(C2 to C5)alkyl, (C1 to C6)trialkylammonium group; ii) placing the aqueous solution of iodoarene from step i) into an electrochemical cell (1), containing a cathode and an anode, wherein the cathode is the counter electrode (1f) and the anode is the working electrode (1g) and comprises a surface containing a boron doped diamond active layer possessing semiconducting or metallic conductivity, which is in direct contact with the aqueous solution of iodoarene; iii) determining the electrode potential of the anode at the anode|electrolyte interface suitable for the oxidation reaction of the iodoarene; iv) applying the electrode potential, determined in step iii), to the aqueous solution of iodoarene of general formula (I) to cause its oxidation into λ 5-iodane of general formula ArI(OR1)(OR2)(OR3)(OR4) and/or ArI(OR1)(OR222, wherein Ar is defined in step i), and R1, R2, R3, R4 are independently selected from the group comprising hydrogen; acyl, which may be attached to the same or different aromatic ring as the iodine atom; (C2 to C6)alkylacyl; sulfonyl group that may be attached to the same or different aromatic ring as iodine atom; (C2 to C6)alkylsulfonyl.

Classes IPC  ?

• C25B 3/07 - Composés contenant au moins un atome d’oxygène
• C25B 3/11 - Composés contenant au moins un atome d’halogènes
• C25B 3/23 - Oxydation
• C25B 11/052 - Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques
• C25B 11/083 - Diamant

Abrégé

A method for preparing an aqueous nanosuspension of API, containing the steps of preparing an aqueous suspension and a crystalline API selected from the group containing API having intrinsic solubility in water of at most 50 mg/L, and having log P of at least 4, and a combination of at least two phospholipidic stabilizing agents containing lipophilic carbohydrate chains having from 6 to 20 carbon atoms; where at least one of the stabilizing agents is PEG-coupled phospholipid of general formula (I), A method for preparing an aqueous nanosuspension of API, containing the steps of preparing an aqueous suspension and a crystalline API selected from the group containing API having intrinsic solubility in water of at most 50 mg/L, and having log P of at least 4, and a combination of at least two phospholipidic stabilizing agents containing lipophilic carbohydrate chains having from 6 to 20 carbon atoms; where at least one of the stabilizing agents is PEG-coupled phospholipid of general formula (I),

Classes IPC  ?

• A61K 9/08 - Solutions
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur

Abrégé

blockstatblockblockstatblockblockstatblockblockstatblockblock-styrene) in the form of the membrane to a reaction with 1-methylpyrrolidine to form a quaternary 1,1-dimethylpyrrolidinium salt covalently bound to the benzene rings of the styrene units. Furthermore, an anion-exchange membrane obtainable by this method is provided.

Classes IPC  ?

• C08J 5/22 - Bandes, membranes ou diaphragmes
• B01D 71/82 - Matériaux macromoléculaires non prévus spécifiquement dans un seul des groupes caractérisés par la présence de groupes déterminés, p. ex. introduits par un post-traitement chimique
• B01J 47/012 - Procédés d'échange d'ions en généralAppareillage à cet effet utilisant un appareil portable d’échange d’ions
• C08F 8/24 - Haloalkylation

Abrégé

The present invention relates to a flow-through electrode assembly having a multilayered structure, comprising, in the following order, a first current collector (a1) suitable for being connected to a power supply; a first electrode plate (c1); a membrane layer (e1) for separating electrode plates; a second electrode plate (c2); and a second current collector (a2) suitable for being connected to a power supply; wherein the first and second electrode plates (c1; c2) contain a layer from an electrically non-conductive material, comprising a chamber (c1.3; c2.3) for electrically-conductive nanomaterial; an inlet channel (c1.1; c2.1) for conducting an electrolyte solution from the stock of electrolyte solution to the chamber (c1.3; c2.3); an outlet channel (c1.2; c2.2) for conducting the electrolyte solution from the chamber (c1.3; c2.3) to the stock of electrolyte solution; and electrically-conductive nanomaterial localized in the chamber (c1.3; c2.3) adapted for being exposed to the electrolyte solution; wherein the electrically-conductive nanomaterial localized in the chamber (c1.3; c2.3) is in direct contact with the first or second current collector (a1; a2) and with the membrane layer (e1); and wherein the membrane layer (e1) comprises a membrane selected from the group comprising an ion-exchange membrane, ultrafiltration membrane, reverse osmosis membrane, nanofiltration membrane. The present invention further relates to a set of at least two serially connected flow-through electrode assemblies, and to the use thereof in electrochemical reactors, redox flow batteries, capacitor batteries, electro(membrane) separation systems, capacitive deionization and/or as electrochemical sensors.

Classes IPC  ?

• H01M 4/86 - Électrodes inertes ayant une activité catalytique, p. ex. pour piles à combustible
• B01D 61/42 - ÉlectrodialyseÉlectro-osmose
• B01D 61/44 - Électrodialyse à sélectivité ionique
• B01D 61/56 - Déshydratation par électro-osmose
• C02F 1/469 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par séparation électrochimique, p. ex. par électro-osmose, électrodialyse, électrophorèse
• H01G 11/24 - Électrodes caractérisées par les propriétés structurelles des matériaux composant les électrodes ou inclus dans les électrodes, p. ex. forme, surface ou porositéÉlectrodes caractérisées par les propriétés structurelles des poudres ou particules utilisées à cet effet
• H01M 4/96 - Électrodes à base de carbone
• H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires

Abrégé

The present invention relates to a computer-implemented method for preparing multiple dosage forms with personalised composition, comprising the following steps: (i) a control unit generates an input protocol of a personalised composition of a multiple dosage form, containing information about the type and amount of individual active substances, the type of cartridge, and the type and number of capsules; (ii) a cartridge of the required type according to the input protocol, labelled with a specific machine-readable code, is placed in the automatic transport system; (iii) at least two different types of sub-units are placed into at least two dosing stations, the sub- unit having sizes in the range of from 0.1 to 4 mm, and containing a different active ingredient and/or different amounts of the same active ingredient and/or having coatings with different solubility and/or possibly containing different pharmaceutical excipients according to the input protocol; (iv) a pre-defined number of capsule bodies is placed in the cartridge placed in an automatic transport system; (v) the automatic transport system transports the cartridge with capsules to the first dosing station, which doses a pre-defined number of the first sub-units into the capsule bodies placed in the cartridge; (vi) the automatic transport system transports the cartridge with capsules to the next dosing station, which doses a pre-defined number of the next sub-units into the capsule bodies placed in the cartridge; and this step is repeated according to the input protocol until the capsules are filled with all of the pre-defined types of sub-units; (vii) the capsules are closed with caps; (viii) the quality control of capsules and discarding of the non-compliant ones; (ix) packaging and labelling with a batch number. The present invention further relates to a device for carrying out this method.

Classes IPC  ?

• A61J 3/07 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de capsules ou de petits conteneurs similaires à absorber par voie buccale

Abrégé

The invention relates to antimicrobial peptides derived from the human protein ameloblastin, intended for therapeutic and biotechnological use, in particular for application onto layers, so-called biofilms, to prevent the growth of specific strains of bacterial microflora, to prevent or remove infectious agents from the surface of joint, dental and bone replacements and to prevent infection of orthopaedic implants.

Classes IPC  ?

• A61P 1/02 - Préparations stomatologiques, p. ex. médicaments pour le traitement des caries, des aphtes, des périodontites
• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
• A61P 31/04 - Agents antibactériens
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères

Abrégé

A device for preparation of liquid marbles that has a belt conveyor for carrying a layer of solid particles, the belt conveyor being provided, successively in the direction of movement of the belt with at least one solids dispenser with a reservoir for solid particles, at least one liquid dispenser with a reservoir for liquid, and a separator for separating the prepared liquid marbles from solid particles, is disclosed.

Classes IPC  ?

• B01J 13/04 - Fabrication de microcapsules ou de microbilles par des procédés physiques, p. ex. séchage, pulvérisation
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet

Abrégé

The present invention relates to a method for the fast and highly efficient production of multi-component powders by spray drying. The method can be applied to already existing small-scale spray dryers available in the market and enables the production of multiple samples with variable composition in continuous mode. The present invention further relates to an automated device adaptable to small-scale spray drying equipment, consisting of an inlet pumping station (1), a cleaning mechanism (2) for the cyclone, a slide valve (3) adaptable to the cyclone, an autosampler (4), analyser (5), and an automatic control device (6) for the whole apparatus.

Classes IPC  ?

• B01J 2/04 - Procédés ou dispositifs pour la granulation de substances, en généralTraitement de matériaux particulaires leur permettant de s'écouler librement, en général, p. ex. en les rendant hydrophobes par division du produit liquide en gouttelettes, p. ex. par pulvérisation, et solidification des gouttelettes en milieu gazeux
• B04B 11/00 - Alimentation, chargement, ou déchargement des tambours
• F26B 3/12 - Procédés de séchage d'un matériau solide ou d'objets impliquant l'utilisation de chaleur par convection, c.-à-d. la chaleur étant transférée d'une source de chaleur au matériau ou aux objets à sécher par un gaz ou par une vapeur, p. ex. l'air le gaz ou la vapeur entraînant le matériau ou les objets à sécher sous forme d'une pulvérisation
• G01N 1/00 - ÉchantillonnagePréparation des éprouvettes pour la recherche
• B01D 1/18 - Évaporation par pulvérisation pour obtenir des solides secs

Abrégé

A formulation of composites having yeast-derived beta glucan particles (GPs) and water-insoluble or poorly-water-soluble low-molecular-weight compounds, such as medicaments or food supplements is disclosed. The composites can exhibit different crystallinity degrees depending on the formulation and, consequently, dissolution kinetics can be controlled. Yeast-derived beta glucan particles are used as carriers for the encapsulation and amorphization of insoluble or poorly water-soluble low-molecular-weight compounds; amorphous formulations exhibiting faster dissolution rates, and consequently, enhanced oral bioavailability. A method of preparation of the composites by spray drying is also disclosed.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• C12P 19/04 - Polysaccharides, c.-à-d. composés contenant plus de cinq radicaux saccharide reliés entre eux par des liaisons glucosidiques
• C12N 1/18 - Levure de boulangerieLevure de bière

Abrégé

1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.

Classes IPC  ?

• C07C 239/20 - Composés hydroxylaminés ou leurs éthers ou esters ayant des atomes d'oxygène de groupes hydroxylamino éthérifiés
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
• A61K 47/61 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique le composé organique macromoléculaire étant un polysaccharide ou l’un de ses dérivés
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique

Abrégé

The present invention provides a device for preparation of liquid marbles, which comprises a belt conveyor (1) for carrying a layer of solid particles, said belt conveyor (1) being provided, successively in the direction of movement of the belt, with at least one solids dispenser (2) with a reservoir for solid particles, at least one liquid dispenser (5) with a reservoir (7) for liquid, and a separator for separating the prepared liquid marbles from solid particles.

Classes IPC  ?

• B01J 13/04 - Fabrication de microcapsules ou de microbilles par des procédés physiques, p. ex. séchage, pulvérisation
• F28D 20/02 - Appareils ou ensembles fonctionnels d'accumulation de chaleur en généralAppareils échangeurs de chaleur de régénération non couverts par les groupes ou utilisant la chaleur latente
• B01J 13/02 - Fabrication de microcapsules ou de microbilles

Abrégé

The secondary battery cell (B, B1, B2, B3) is based on glass. Every composite layer (K1.1; K2.1, K2.2; K3.1, K3.2, K3.3) of the cathode (K; K1; K2; K3) or (E1.1; E2.1, E2.2; E3.1, E.2, E3.3) of the electrolyte (E; E1; E2; E3) or (A1.1; A2.1, A2.2; A3.1, A3.2, A3.3) of the anode (A; A1; A2; A3) contains: 0.1 to 10.0% volume of the first additive (A1K; A 1E; A1A) for an increase in electrochemical oxidation-reduction activity of these composite layers; 0.1 to 10.0% volume of the second additive (A2K; A2E; A2A) on the surface of micro- and nanofibres and micro- and nanoparticles for an increase in adhesion of these composite layers; and 80 to 99.8% by volume of selected glass (GMCK; GFIC; GMCA). Each of these composite layers of the cathode (K; K1; K2; K3), electrolyte (E; E1; E2; E3) and anode (A; A1; A2; A3) states a gradual change in the function-gradient concentration of immobile components of composite layers in the direction from the cathode (K) to the anode (A), depending on the distance between the collector (KK) of the cathode (K) and the opposite collector (KA) of the anode (A), and in the inverse direction, and the mobile component in these glass materials (GMCK; GMCA; GFIC) is either the lithium cation Li+or the sodium cation Na+. The claims cover also the method of production of the secondary battery cell (B, B1, B2, B3).

Classes IPC  ?

• H01M 4/04 - Procédés de fabrication en général
• H01M 4/131 - Électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx
• H01M 4/36 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs
• H01M 4/13 - Électrodes pour accumulateurs à électrolyte non aqueux, p. ex. pour accumulateurs au lithiumLeurs procédés de fabrication
• H01M 4/48 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques
• H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
• H01M 10/04 - Structure ou fabrication en général
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p. ex. au magnésium ou à l'aluminium
• H01M 10/0562 - Matériaux solides
• H01M 10/0585 - Structure ou fabrication d'accumulateurs ayant uniquement des éléments de structure plats, c.-à-d. des électrodes positives plates, des électrodes négatives plates et des séparateurs plats
• H01M 50/437 - Verre
• H01M 50/44 - Matériau fibreux
• H01M 50/443 - Matériau particulaire
• H01M 50/449 - Séparateurs, membranes ou diaphragmes caractérisés par le matériau ayant une structure en couches
• H01M 50/46 - Séparateurs, membranes ou diaphragmes caractérisés par leur combinaison avec des électrodes
• H01M 50/489 - Séparateurs, membranes, diaphragmes ou éléments d’espacement dans les cellules caractérisés par leurs propriétés physiques, p. ex. degré de gonflement, hydrophilicité ou propriétés pour court-circuiter
• D01D 5/00 - Formation des filaments, fils ou similaires
• D01F 1/10 - Autres agents modifiant les propriétés de ces filaments
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
• B82Y 40/00 - Fabrication ou traitement des nanostructures
• H01M 4/134 - Électrodes à base de métaux, de Si ou d'alliages
• H01M 4/139 - Procédés de fabrication
• H01M 50/497 - Conductivité ionique
• D01D 5/28 - Formation des filaments, fils ou similaires avec mélange des différentes solutions ou masses de filage au cours du filageEnsembles de filage à cet effet
• D01D 10/02 - Traitement thermique
• D04H 3/002 - Fils ou filaments inorganiques
• H01M 4/136 - Électrodes à base de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFy

Abrégé

The present invention relates to a formulation of composites comprised of yeast-derived beta glucan particles (GPs) and water-insoluble or poorly-water-soluble low-molecular-weight compounds, such as medicaments (drugs) or food supplements. The composites can exhibit different crystallinity degrees depending on the formulation and, consequently, dissolution kinetics can be controlled. Yeast-derived beta glucan particles are used as carriers for the encapsulation and amorphization of insoluble or poorly-water-soluble low-molecular-weight compounds; amorphous formulations exhibiting faster dissolution rates, and consequently, enhanced oral bioavailability. The present invention further relates to a method of preparation of the composites by spray drying, and the use thereof.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques

Produits et services

Pamphlets; Informational letters; Catalogues; Flyers; Visiting cards; Invitation cards; Events programmes; Promotional publications; Study guides; Printed questionnaires; Printed leaflets; Printed news releases; Educational publications. Advertising; Public relations services. Dissemination of educational material; Education and instruction services; Arranging and conducting of seminars and workshops; Publication and editing of printed matter; Electronic publishing services; Organisation of seminars.

Abrégé

The electrodes, anode (A) as well as cathode (K), are electronically and ionically conductive, contain solid amorphous glass composite material and also glass and/or metallic fibres and glass and/or crystalline particles with a mean diameter in nano/micrometres from 1 nm to 100 μm. Their surface is nano/micro-structural with mean roughness from 1 nm to 100 μm; and contains, as ionic charge carriers, migrating lithium and/or sodium cations for migration from the anode (A) through the electrolyte (E) to the cathode (K) during discharging of the secondary battery cell (B) and from the cathode (K) to the anode (A) during recharging of the secondary battery cell (B). The electrolyte (E) is ion-conducting, it contains solid amorphous glass composite material with lithium and/or sodium cations as the ionic charge carriers. The composition of the glass for the electrodes (A, K) as well as electrolyte (E) and their conductivity are claimed. The composite material of the electrodes (A, K) contains active oxidation-reduction centres based on metallic silicon and/or silicon oxides and/or glasses containing electropositive polyvalent elements Mp, where these oxidation-reduction centres have the ratio of the higher oxidation state to the lower oxidation state of polyvalent elements Mp from 0.1 to 10, and thus also create gradient nano/micro composite glass material of the electrodes (A, K) with mixed ionic and electron conductivity. The oxidation-reduction centres have polyvalent elements Mp which for the assurance of reversible oxidation- reduction reactions are able to,transfer their oxidation states.

Classes IPC  ?

• H01M 4/131 - Électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx
• H01M 4/134 - Électrodes à base de métaux, de Si ou d'alliages
• H01M 4/136 - Électrodes à base de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFy
• H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
• H01M 4/48 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques
• H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/0562 - Matériaux solides
• H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p. ex. au magnésium ou à l'aluminium

Abrégé

The invention provides a method for recovering lithium and optionally further alkali metal compounds, a mineral from the group of phyllosilicates containing lithium and optionally further alkali metals and also at least 0.2 wt. %, preferably at least 0.9 wt. %, of fluorine, is subjected to a thermal treatment in a furnace at a temperature within the range of from 1100 °C to 1700 °C, preferably at a temperature within the range of from 1220 °C to 1700 °C, at a pressure within the range of from 20 kPa to 150 kPa for a period of 15 to 360 minutes, in the presence of a reagent which contains a) at least one substance from a group comprising carbonates, oxides, hydroxides, sulfates, sulfites and chlorides of alkaline earth metals, in particular calcium; and b) at least one substance capable of releasing chlorine and/or hydrogen chloride and/or sulfur trioxide and/or sulfur dioxide during the thermal treatment, wherein the molar ratio of the total amount of sulfur trioxide and/or sulfur dioxide expressed as S03 and/or of chlorine and/or hydrogen chloride expressed as Cl2 to the total amount of alkali metals including lithium, released from the silicate mineral in the reaction space in the furnace, is at least 0.5, the content of alkaline earth metals, in particular calcium, recalculated as the their oxide content, in the mixture of the phyllosilicate mineral with the reagent is at least 20 wt. %, and the fluorine content in the mixture of the phyllosilicate mineral with the reagent is from 0.1 to 2 wt. %, preferably from 0.2 to 2 wt. %, for decomposition of the structure of the phyllosilicate mineral and for volatilization of lithium compounds and optionally further alkali metal compounds from the thermally treated phyllosilicate mineral, and the compounds of lithium and optionally of further alkali metals are subsequently recovered by condensation by drawing off from 50 to 100 vol. % of flue gas formed in the furnace from the furnace from one or more different places having different temperatures., wherein the rate and volume of the drawn off flue gases from different places can be different for the selective recovery of compounds of individual alkali metals or their groups.

Classes IPC  ?

• C01D 1/00 - Oxydes ou hydroxydes de sodium, de potassium ou des métaux alcalins en général
• C01D 3/00 - Halogénures de sodium, de potassium ou des métaux alcalins en général
• C01D 15/00 - Composés du lithium
• C04B 7/36 - Fabrication des ciments hydrauliques en général

Abrégé

The invention provides methods for imaging biological tissue. The disclosed polymethenium salts show activity as two photon imaging agents, having a greater imaging depth and photostability than known agents, whilst having lower toxicity. The methods show great selectivity for mitochondria. The methods have utility in both in vitro and in vivo imaging, for example, imaging of tumours.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• A61K 49/00 - Préparations pour examen in vivo
• C07D 401/00 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote
• C07D 417/00 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe
• C09B 23/01 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique
• C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines

Abrégé

New aminooxylipids of general formula (I), wherein n1 = 5-30 and X is polymethylene linker of the general formula (II) where n2 = 2 -10, or X is polyethylene glycol linker of the general formula (III), wherein n3 = 1-14, are provided. A method of preparation of the aminooxylipids of general formula (I) characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C-0-(C=0)-HN-(CH2)n-N H2, n = 2 -13}, or N-tert- butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C-0-(C=0)-HN-(CH2)2-[0-(CH2)]n-0-(CH2)2NH2, n = 1-14} with in position C(2) symmetrically branched fatty acids of general formula (IV), wherein n1 = 5-30, in the presence of condensation reagent, or from acid of general formula (IV) derived acylchloride of general formula (V) wherein n1 = 5-30, produces N-Boc-aminolipids of general formula (VI), wherein n1 = 5-30 a X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). These are converted by debocylation to aminolipids of general formula (VII), wherein n1 = 5-30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). By their condensation with N-terf-butoxycarbonyl-aminooxyacetic acid in the presence of condensation reagent, N-Boc-aminooxylipids of general formula (VIII), where in n1 = 5- 30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III), are obtained, which by debocylation afford aminooxylipids of general formula (I). Acylchlorides of general formula (V) are prepared by reaction of acid of general formula (IV) with oxalylchloride in the presence of catalytic amount of N, N-dimethylformamide in organic aprotic solvent. The use of nontoxic aminooxylipids of the general formula I for construction of nontoxic self-assembly liposomal carriers of therapeutics presenting aminooxy groups and so-called "post-liposomal" modification of these carriers with biologically functional molecules using oxime ligation technique (binding counterparts: aminooxy group and aldehyde or ketone group).

Classes IPC  ?

• C07C 235/08 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone acycliques et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné le squelette carboné étant acyclique et saturé ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone acyclique d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• C07C 235/10 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone acycliques et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné le squelette carboné étant acyclique et saturé ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone acyclique d'un radical hydrocarboné substitué par des atomes d'azote ne faisant pas partie de groupes nitro ou nitroso
• A61K 47/50 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament

Abrégé

The present invention relates to photoactivatable nanoparticles for photodynamic applications containing a photosensitizer, a (C8 to C22) fatty alcohol and a polymeric surfactant, preferably poly(ethylene oxide) monomethyl ether-block-poly(ε-caprolactone), whereas the size of the nanoparticle is in the range of from 1 to 1000 nm, and the core of the nanoparticle is solid at the temperature of 4 °C, and liquid at the temperature around 39 °C. The present invention further relates to a method of preparation of the photoactivatable nanoparticle, a pharmaceutical composition containing it, and use thereof.

Classes IPC  ?

• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Agents anticancéreux

Abrégé

− independently represent anions of pharmaceutically acceptable salts.

Classes IPC  ?

• C07D 471/22 - Composés hétérocycliques contenant des atomes d'azote comme uniques hétéro-atomes du système condensé, au moins un cycle étant un cycle à six chaînons avec un atome d'azote, non prévus dans les groupes dans lesquels le système condensé contient au moins quatre hétérocycles
• A61K 31/475 - QuinoléinesIsoquinoléines ayant un cycle indole, p. ex. yohimbine, réserpine, strychnine, vinblastine
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention provides new strains of lactobacilli, producing substances effective against vaginal pathogens, Lactobacillus crispatus CCM 7997; Lactobacillus reuteri CCM 7998; Lactobacillus crispatus CCM 8522; Lactobacillus fermentum CCM 8523. These new strains of lactobacilli are suitable for the prevention and/or treatment of chronic urogenital infections, restoration of natural vaginal microflora, and/or for elimination of discomfort of women during pre-menstrual and menstrual period. They can be used as active ingredients in medicaments or in sanitary products.

Classes IPC  ?

• A61K 35/747 - Lactobacilles, p. ex. L. acidophilus ou L. brevis
• A61P 15/02 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les pathologies du vagin
• A61P 13/00 - Médicaments pour le traitement des troubles du système urinaire
• A61F 13/15 - Garnitures absorbantes, p. ex. serviettes ou tampons hygiéniques pour application externe ou interne au corpsMoyens pour les maintenir en place ou les fixerApplicateurs de tampons
• C12N 1/20 - BactériesLeurs milieux de culture

Abrégé

The invention relates to a method of isolation of polyhydroxyalkanoates from biomass containing polyhydroxyalkanoates comprising the steps of extracting components of the biomass other than polyhydroxyalkanoates from the biomass by means of an extraction agent based on alkyl alcohol having 2 to 4 carbon atoms in the chain, separating the extract containing these components from the extraction solution thus obtained, removing the remainder of the extraction agent from the solid phase by distillation with an aqueous solution or by stripping with water vapour or by drying, extracting from the solid phase thus pre-cleaned polyhydroxyalkanoates by an extraction agent based on chlorinated hydrocarbon, separating the polyhydroxyalkanoates from the extraction solution thus obtained, and feeding this extract to a circulation loop in order to obtain a polyhydroxyalkanoates precipitate.

Classes IPC  ?

• C08G 63/90 - PurificationSéchage
• C12P 7/62 - Esters d’acides carboxyliques

Abrégé

The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C4 alkyl, up to three of S1,2, S1',2', S3,4 and S3',4' are present, each of S1,2, S1',2', S3,4 and S3',4' independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, preferably hydrocarbon chain having 4 carbon atoms, more preferably hydrocarbon chain having 4 carbon atoms and two double bonds, and one to four atoms selected from the carbon atoms with the descriptor 2, 4, 2', and 4' are substituted with a substituent R3 of general formula II, wherein R4 is substituted or unsubstituted heteroaryl, T1 and T2 are independent linkers that bridge atoms N5 with C8 and N5´ with C8´, wherein T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, preferably 2 or 3 carbon atoms; and anions (X1 )- and (X2 )- independently represent anions of pharmaceutically acceptable salts. The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases and in the treatment, requiring affecting of G-quadruplex, preferably at telomeres or in gene promoters. ˙

Classes IPC  ?

• C07D 471/04 - Systèmes condensés en ortho
• A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to the method of preparation of a soluble block copolymer poly(styrene-block-C2-C4alkylene-stat-C2-C4alkylene-block-styrene) chloromethylated into a chloromethylation degree higher than 35 %. The principle of this method lies in a reaction of the starting block copolymer poly(styrene-block-C2-C4alkylene-stat-C2-C4alkylene-block-styrene) with dimethoxymethane, a chlorinating agent, and ZnCl2 catalyst, preferably at the temperature in the range of from 10 °C to 65 °C, with no direct use of chloroalkyl ethers and with no side cross-linking reaction. The invention further describes the use of this method for the preparation of homogeneous or microheterogeneous anion-exchange membranes, particularly by chloromethylated solution casting, its reaction with trialkylamine or trialkylphosphine, and their use for electrode impregnation in electrochemical devices, as catalyst carriers, for preparation of ion-exchange membranes and binders in electrochemical devices, ion-exchange applications and catalytic systems.

Classes IPC  ?

• B01J 47/12 - Procédés d'échange d'ions en généralAppareillage à cet effet caractérisés par l'emploi d'une substance échangeur d'ions sous forme de rubans, de filaments, de fibres ou de feuilles, p. ex. sous forme de membranes
• B01D 71/82 - Matériaux macromoléculaires non prévus spécifiquement dans un seul des groupes caractérisés par la présence de groupes déterminés, p. ex. introduits par un post-traitement chimique
• C08J 5/22 - Bandes, membranes ou diaphragmes
• C08F 8/24 - Haloalkylation

Abrégé

Device for elimination of gaseous noxious substances from an air mass, comprising: - an incineration module (2) having an inlet orifice for feeding the air mass and an outlet orifice for exhausting the air mass, - at least one heating wire (5) arranged inside the incineration module (2), and - a regulating unit that is interconnectable the heating wire (5) and adapted for adjusting the temperature of the heating wire.

Classes IPC  ?

• B01D 53/44 - Composants organiques
• B01D 53/72 - Composés organiques non prévus dans les groupes , p. ex. hydrocarbures
• B01D 53/00 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols
• F01N 3/26 - Structure des réacteurs thermiques

Abrégé

Energy sources, such as industrial glass burners (11), heating electrodes (10) and other suitable heating energy sources operate on the molten glass melt (6) containing undissolved particles, especially glass sand and bubbles, in the longitudinal axis of the melting space, or in a direction parallel with this longitudinal axis, until creation of one or more longitudinal temperature barriers in the glass melt (6) and until the arising of the cross temperature gradient [K.m-1] which generates spiral-type flowing of the glass melt (6) with a rotary movement across the melting space, and in fact perpendicularly to the longitudinal axis of the melting part. This spiral-type flowing proceeds in the direction from the front wall (2) to the submerged cross refractory barrier (7) in the glass melt (6), or in the direction from the front wall (2) to the cross row (9) of the energy sources. The transversal temperature gradient [K.m-1] of each spiral-type flowing is always set as higher than longitudinal temperature gradient [K.m-1] between the front wall (2) and the submerged cross refractory barrier (7) in the glass melt (6), or between the front wall (2) and the cross row (9) of the energy sources, as a consequence of which it is possible to utilise 0.6 to 0.8 multiple of the total melting space. The ratio of the cross temperature gradient [K.m-1] to the longitudinal temperature gradient [K.m-1] is higher than 1 and lower than 30, preferably it is within the range from 5 to 20. Energy sources, such as heating electrodes (10) and/or industrial glass burners (11) in the melting space are arranged for creation of one or more longitudinal temperature barriers in the glass melt (6) and for generation of the spiral-type flowing of glass melt (6) with a rotary movement across the melting part, in fact perpendicularly to the longitudinal axis of the melting part, and for the setting of the cross temperature gradient [K.m-1] of the spiral-type flowing higher than the longitudinal temperature gradient [K.m-1].

Classes IPC  ?

• C03B 5/183 - AgitateursHomogénéisation en utilisant des moyens thermiques, p. ex. pour créer des courants de convection
• C03B 5/185 - Moyens électriques

Abrégé

The invention relates to a method of anchoring nanostructures (5) of gold on the surface of the base material (1). First, chemical bonds on the surface of the base material (1) are split by action of high - energetic particles, while at least portion of radicals (2) and/or conjugated double bonds (3) created by this way spontaneously oxides by contact with atmosphere to obtain oxygenous groups. Afterwards, the radicals (2) and/or double bonds (3) and/or oxygenous groups on surface of the base material (1) by means of chemical reaction between them and mercapto group (-SH) or amino group (-NH2) or hydroxyl group (-0H), molecules of dithiol and/or thiol are bonded. Subsequently by means of chemical reaction between their unsaturated mercapto group (-SH) and gold, nanostructures of gold are bonded, being thus anchored on surface of the base material (1). The method can also be used for anchoring layer of gold. The invention also relates to a substrate prepared by these methods.

Classes IPC  ?

• B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat

Abrégé

The invention relates to a method for anchoring carbon nanoparticles onto surface of a base material, by which chemical bond based on amino group (-NH2), resp. physical bond based on an organic substance containing mercapto group (-SH) and/or hydroxy group (-OH) and/or amino group (-NH2) is created between surface of the base material and carbon nanoparticles. The inventions also relates to a substrate comprising base material and layer of carbon nanoparticles, which is anchored to the base material by chemical bond based on amino group (-NH2), resp. by physical bond based on an organic substance containing mercapto group (-SH) and/or hydroxyl group (-OH) and/or amino group (-NH2).

Classes IPC  ?

• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées

Abrégé

The method for brown coal coke production is based on the fact that brown coal with carbon content in dry matter of 60 to 75% by weight, volatile matter 40 to 60% by weight and tar 17.5 to 30% by weight is by crushing and grinding modified to the grain-size of under 0.25 mm, moistened to the total water content ranging between 10 and 25% by weight; the homogenised mixture is placed in the retort, and after its compacting it is indirectly heated to the internal temperature of the retort between 950 to 1300°C and kept at this temperature for 2 hours or more. The product is subsequently removed from the retort after cooling to the surface temperature of 400°C.

Classes IPC  ?

• C10L 9/08 - Traitement des combustibles solides en vue d'améliorer leur combustion par traitement thermique, p. ex. calcination
• C10B 57/04 - Autres procédés de carbonisation ou de cokéfactionCaractéristiques générales des procédés de distillation destructive utilisant des charges de composition spéciale

Abrégé

New aminooxylipids of general formula (I), wherein n1 = 5-30 and X is polymethylene linker of the general formula (II) where n2 = 2 -10, or X is polyethylene glycol linker of the general formula (III), wherein n3 = 1-14, are provided. A method of preparation of the aminooxylipids of general formula (I) characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C-0-(C=0)-HN-(CH2)n-N H2, n = 2 -13}, or N-tert- butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C-0-(C=0)-HN-(CH2)2-[0-(CH2)]n-0-(CH2)2NH2, n = 1-14} with in position C(2) symmetrically branched fatty acids of general formula (IV), wherein n1 = 5-30, in the presence of condensation reagent, or from acid of general formula (IV) derived acylchloride of general formula (V) wherein n1 = 5-30, produces N-Boc-aminolipids of general formula (VI), wherein n1 = 5-30 a X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). These are converted by debocylation to aminolipids of general formula (VII), wherein n1 = 5-30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). By their condensation with N-terf-butoxycarbonyl-aminooxyacetic acid in the presence of condensation reagent, N-Boc-aminooxylipids of general formula (VIII), where in n1 = 5- 30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III), are obtained, which by debocylation afford aminooxylipids of general formula (I). Acylchlorides of general formula (V) are prepared by reaction of acid of general formula (IV) with oxalylchloride in the presence of catalytic amount of N, N-dimethylformamide in organic aprotic solvent. The use of nontoxic aminooxylipids of the general formula I for construction of nontoxic self-assembly liposomal carriers of therapeutics presenting aminooxy groups and so-called "post-liposomal" modification of these carriers with biologically functional molecules using oxime ligation technique (binding counterparts: aminooxy group and aldehyde or ketone group).

Classes IPC  ?

• A61K 47/50 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament
• C07C 235/08 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone acycliques et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné le squelette carboné étant acyclique et saturé ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone acyclique d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples
• C07C 235/10 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone acycliques et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné le squelette carboné étant acyclique et saturé ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone acyclique d'un radical hydrocarboné substitué par des atomes d'azote ne faisant pas partie de groupes nitro ou nitroso

Abrégé

The present invention provides a device for preparation of liquid marbles, which comprises a belt conveyor (1) for carrying a layer of solid particles, said belt conveyor (1) being provided, successively in the direction of movement of the belt, with at least one solids dispenser (2) with a reservoir for solid particles, at least one liquid dispenser (5) with a reservoir (7) for liquid, and a separator for separating the prepared liquid marbles from solid particles.

Classes IPC  ?

• B01J 13/02 - Fabrication de microcapsules ou de microbilles
• B01J 13/04 - Fabrication de microcapsules ou de microbilles par des procédés physiques, p. ex. séchage, pulvérisation
• F28D 20/02 - Appareils ou ensembles fonctionnels d'accumulation de chaleur en généralAppareils échangeurs de chaleur de régénération non couverts par les groupes ou utilisant la chaleur latente

Classes IPC  ?

• A61J 3/07 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de capsules ou de petits conteneurs similaires à absorber par voie buccale

Abrégé

The invention provides a method for recovering lithium and optionally further alkali metal compounds, a mineral from the group of phyllosilicates containing lithium and optionally further alkali metals and also at least 0.2 wt. %, preferably at least 0.9 wt. %, of fluorine, is subjected to a thermal treatment in a furnace at a temperature within the range of from 1100 °C to 1700 °C, preferably at a temperature within the range of from 1220 °C to 1700 °C, at a pressure within the range of from 20 kPa to 150 kPa for a period of 15 to 360 minutes, in the presence of a reagent which contains a) at least one substance from a group comprising carbonates, oxides, hydroxides, sulfates, sulfites and chlorides of alkaline earth metals, in particular calcium; and b) at least one substance capable of releasing chlorine and/or hydrogen chloride and/or sulfur trioxide and/or sulfur dioxide during the thermal treatment, wherein the molar ratio of the total amount of sulfur trioxide and/or sulfur dioxide expressed as S03 and/or of chlorine and/or hydrogen chloride expressed as Cl2 to the total amount of alkali metals including lithium, released from the silicate mineral in the reaction space in the furnace, is at least 0.5, the content of alkaline earth metals, in particular calcium, recalculated as the their oxide content, in the mixture of the phyllosilicate mineral with the reagent is at least 20 wt. %, and the fluorine content in the mixture of the phyllosilicate mineral with the reagent is from 0.1 to 2 wt. %, preferably from 0.2 to 2 wt. %, for decomposition of the structure of the phyllosilicate mineral and for volatilization of lithium compounds and optionally further alkali metal compounds from the thermally treated phyllosilicate mineral, and the compounds of lithium and optionally of further alkali metals are subsequently recovered by condensation by drawing off from 50 to 100 vol. % of flue gas formed in the furnace from the furnace from one or more different places having different temperatures., wherein the rate and volume of the drawn off flue gases from different places can be different for the selective recovery of compounds of individual alkali metals or their groups.

Classes IPC  ?

• C01D 1/00 - Oxydes ou hydroxydes de sodium, de potassium ou des métaux alcalins en général
• C01D 3/00 - Halogénures de sodium, de potassium ou des métaux alcalins en général
• C01D 15/00 - Composés du lithium
• C04B 7/36 - Fabrication des ciments hydrauliques en général

Abrégé

Date de soumission / Date Submitted: 2021/09/23
No de la demande can. / CA App. No.: 3131583
Abrégé:
La présente invention concerne une forrnulation de cornposites comprenant des
particules de
bêta-glucane dérivées de levure (GPs) et des cornposés de faible poids
moléculaire insolubles ou peu
solubles dans l'eau, tels que des rnédicarnents ou des suppléments
alimentaires. Les cornposites
peuvent présenter différents degrés de cristallinité en fonction de la
formulation et, par conséquent,
la cinétique de dissolution peut être régulée. Des particules de bita-glucane
dérivées de levure sont
utilisées en tant qu'excipients pour l'encapsulation et l'amorphisation de
composés de faible poids
rnoléculaire insolubles ou peu solubles dans l'eau ; des forrnulations
arnorphes présentant des
vitesses de dissolution plus rapides, et par conséquent, une biodisponibilité
orale améliorée.
L'invention concerne égalernent un procédé de préparation des cornposites par
séchage par
pulvérisation ainsi que son utilisation.
Abstract:
The present invention relates to a formulation of composites cornprised of
yeast-derived beta glucan
particles (GPs) and water-insoluble or poorly-water-soluble low-rnolecular-
weight cornpounds, such
as medicaments (drugs) or food supplernents. The composites can exhibit
different crystallinity
degrees depending on the formulation and, consequently, dissolution kinetics
can be controlled.
Yeast-derived beta glucan particles are used as carriers for the encapsulation
and amorphization of
insoluble or poorly-water-soluble low-molecular-weight compounds; amorphous
formulations
exhibiting faster dissolution rates, and consequently, enhanced oral
bioavailability. The present
invention further relates to a rnethod of preparation of the composites by
spray drying, and the use
thereof.

Classes IPC  ?

• A61K 9/16 - AgglomérésGranulésMicrobilles