Abstract

The present invention relates to a computer-implemented method for preparing multiple dosage forms with personalised composition, comprising the following steps: (i) a control unit generates an input protocol of a personalised composition of a multiple dosage form, containing information about the type and amount of individual active substances, the type of cartridge, and the type and number of capsules; (ii) a cartridge of the required type according to the input protocol, labelled with a specific machine-readable code, is placed in the automatic transport system; (iii) at least two different types of sub-units are placed into at least two dosing stations, the sub-unit having sizes in the range of from 0.1 to 4 mm, and containing a different active ingredient and/or different amounts of the same active ingredient and/or having coatings with different solubility and/or possibly containing different pharmaceutical excipients according to the input protocol; (iv) a pre-defined number of capsule bodies is placed in the cartridge placed in an automatic transport system; (v) the automatic transport system transports the cartridge with capsules to the first dosing station, which doses a pre-defined number of the first sub-units into the capsule bodies placed in the cartridge; (vi) the automatic transport system transports the cartridge with capsules to the next dosing station, which doses a pre-defined number of the next sub-units into the capsule bodies placed in the cartridge; and this step is repeated according to the input protocol until the capsules are filled with all of the pre-defined types of sub-units; (vii) the capsules are closed with caps; (viii) the quality control of capsules and discarding of the non-compliant ones; (ix) packaging and labelling with a batch number. The present invention relates to a computer-implemented method for preparing multiple dosage forms with personalised composition, comprising the following steps: (i) a control unit generates an input protocol of a personalised composition of a multiple dosage form, containing information about the type and amount of individual active substances, the type of cartridge, and the type and number of capsules; (ii) a cartridge of the required type according to the input protocol, labelled with a specific machine-readable code, is placed in the automatic transport system; (iii) at least two different types of sub-units are placed into at least two dosing stations, the sub-unit having sizes in the range of from 0.1 to 4 mm, and containing a different active ingredient and/or different amounts of the same active ingredient and/or having coatings with different solubility and/or possibly containing different pharmaceutical excipients according to the input protocol; (iv) a pre-defined number of capsule bodies is placed in the cartridge placed in an automatic transport system; (v) the automatic transport system transports the cartridge with capsules to the first dosing station, which doses a pre-defined number of the first sub-units into the capsule bodies placed in the cartridge; (vi) the automatic transport system transports the cartridge with capsules to the next dosing station, which doses a pre-defined number of the next sub-units into the capsule bodies placed in the cartridge; and this step is repeated according to the input protocol until the capsules are filled with all of the pre-defined types of sub-units; (vii) the capsules are closed with caps; (viii) the quality control of capsules and discarding of the non-compliant ones; (ix) packaging and labelling with a batch number. The present invention further relates to a device for carrying out this method.

IPC Classes  ?

• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]

Abstract

The present invention relates to a bipolar plate comprising a metal plate and at least one coating layer disposed on the metal plate, wherein the coating layer comprises a cured coating composition comprising: a) a matrix comprising at least one polymeric resin; and b) a plurality of conductive particles dispersed within the matrix; wherein a number of the conductive particles are arranged in the matrix so as to form a plurality of aligned particle assemblies constituting electrically conductive pathways extending across the thickness of the coating layer.

IPC Classes  ?

• H01M 8/0206 - Metals or alloys
• H01M 8/0226 - Composites in the form of mixtures
• H01M 8/0228 - Composites in the form of layered or coated products

Abstract

The present invention relates to a method for electrochemical synthesis of λ 53222, wherein R is independently selected from the group comprising (C1 to C10)alkyl, linear methoxy-(C2 to C5)alkyl, (C1 to C6)trialkylammonium group; ii) placing the aqueous solution of iodoarene from step i) into an electrochemical cell (1), containing a cathode and an anode, wherein the cathode is the counter electrode (1f) and the anode is the working electrode (1g) and comprises a surface containing a boron doped diamond active layer possessing semiconducting or metallic conductivity, which is in direct contact with the aqueous solution of iodoarene; iii) determining the electrode potential of the anode at the anode|electrolyte interface suitable for the oxidation reaction of the iodoarene; iv) applying the electrode potential, determined in step iii), to the aqueous solution of iodoarene of general formula (I) to cause its oxidation into λ 5-iodane of general formula ArI(OR1)(OR2)(OR3)(OR4) and/or ArI(OR1)(OR222, wherein Ar is defined in step i), and R1, R2, R3, R4 are independently selected from the group comprising hydrogen; acyl, which may be attached to the same or different aromatic ring as the iodine atom; (C2 to C6)alkylacyl; sulfonyl group that may be attached to the same or different aromatic ring as iodine atom; (C2 to C6)alkylsulfonyl.

IPC Classes  ?

• C25B 3/07 - Oxygen containing compounds
• C25B 3/11 - Halogen containing compounds
• C25B 3/23 - Oxidation
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/083 - Diamond

Abstract

A method for preparing an aqueous nanosuspension of API, containing the steps of preparing an aqueous suspension and a crystalline API selected from the group containing API having intrinsic solubility in water of at most 50 mg/L, and having log P of at least 4, and a combination of at least two phospholipidic stabilizing agents containing lipophilic carbohydrate chains having from 6 to 20 carbon atoms; where at least one of the stabilizing agents is PEG-coupled phospholipid of general formula (I), A method for preparing an aqueous nanosuspension of API, containing the steps of preparing an aqueous suspension and a crystalline API selected from the group containing API having intrinsic solubility in water of at most 50 mg/L, and having log P of at least 4, and a combination of at least two phospholipidic stabilizing agents containing lipophilic carbohydrate chains having from 6 to 20 carbon atoms; where at least one of the stabilizing agents is PEG-coupled phospholipid of general formula (I),

IPC Classes  ?

• A61K 9/08 - Solutions
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

blockstatblockblockstatblockblockstatblockblockstatblockblock-styrene) in the form of the membrane to a reaction with 1-methylpyrrolidine to form a quaternary 1,1-dimethylpyrrolidinium salt covalently bound to the benzene rings of the styrene units. Furthermore, an anion-exchange membrane obtainable by this method is provided.

IPC Classes  ?

• C08J 5/22 - Films, membranes or diaphragms
• B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
• B01J 47/012 - Ion-exchange processes in generalApparatus therefor using portable ion-exchange apparatus
• C08F 8/24 - Haloalkylation

Abstract

The present invention relates to a flow-through electrode assembly having a multilayered structure, comprising, in the following order, a first current collector (a1) suitable for being connected to a power supply; a first electrode plate (c1); a membrane layer (e1) for separating electrode plates; a second electrode plate (c2); and a second current collector (a2) suitable for being connected to a power supply; wherein the first and second electrode plates (c1; c2) contain a layer from an electrically non-conductive material, comprising a chamber (c1.3; c2.3) for electrically-conductive nanomaterial; an inlet channel (c1.1; c2.1) for conducting an electrolyte solution from the stock of electrolyte solution to the chamber (c1.3; c2.3); an outlet channel (c1.2; c2.2) for conducting the electrolyte solution from the chamber (c1.3; c2.3) to the stock of electrolyte solution; and electrically-conductive nanomaterial localized in the chamber (c1.3; c2.3) adapted for being exposed to the electrolyte solution; wherein the electrically-conductive nanomaterial localized in the chamber (c1.3; c2.3) is in direct contact with the first or second current collector (a1; a2) and with the membrane layer (e1); and wherein the membrane layer (e1) comprises a membrane selected from the group comprising an ion-exchange membrane, ultrafiltration membrane, reverse osmosis membrane, nanofiltration membrane. The present invention further relates to a set of at least two serially connected flow-through electrode assemblies, and to the use thereof in electrochemical reactors, redox flow batteries, capacitor batteries, electro(membrane) separation systems, capacitive deionization and/or as electrochemical sensors.

IPC Classes  ?

• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
• B01D 61/42 - ElectrodialysisElectro-osmosis
• B01D 61/44 - Ion-selective electrodialysis
• B01D 61/56 - Electro-osmotic dewatering
• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• H01G 11/24 - Electrodes characterised by structural features of the materials making up or comprised in the electrodes, e.g. form, surface area or porosityElectrodes characterised by the structural features of powders or particles used therefor
• H01M 4/96 - Carbon-based electrodes
• H01M 8/18 - Regenerative fuel cells, e.g. redox flow batteries or secondary fuel cells

IPC Classes  ?

• A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

Abstract

The present invention relates to a computer-implemented method for preparing multiple dosage forms with personalised composition, comprising the following steps: (i) a control unit generates an input protocol of a personalised composition of a multiple dosage form, containing information about the type and amount of individual active substances, the type of cartridge, and the type and number of capsules; (ii) a cartridge of the required type according to the input protocol, labelled with a specific machine-readable code, is placed in the automatic transport system; (iii) at least two different types of sub-units are placed into at least two dosing stations, the sub- unit having sizes in the range of from 0.1 to 4 mm, and containing a different active ingredient and/or different amounts of the same active ingredient and/or having coatings with different solubility and/or possibly containing different pharmaceutical excipients according to the input protocol; (iv) a pre-defined number of capsule bodies is placed in the cartridge placed in an automatic transport system; (v) the automatic transport system transports the cartridge with capsules to the first dosing station, which doses a pre-defined number of the first sub-units into the capsule bodies placed in the cartridge; (vi) the automatic transport system transports the cartridge with capsules to the next dosing station, which doses a pre-defined number of the next sub-units into the capsule bodies placed in the cartridge; and this step is repeated according to the input protocol until the capsules are filled with all of the pre-defined types of sub-units; (vii) the capsules are closed with caps; (viii) the quality control of capsules and discarding of the non-compliant ones; (ix) packaging and labelling with a batch number. The present invention further relates to a device for carrying out this method.

IPC Classes  ?

• A61J 3/07 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

Abstract

The invention relates to antimicrobial peptides derived from the human protein ameloblastin, intended for therapeutic and biotechnological use, in particular for application onto layers, so-called biofilms, to prevent the growth of specific strains of bacterial microflora, to prevent or remove infectious agents from the surface of joint, dental and bone replacements and to prevent infection of orthopaedic implants.

IPC Classes  ?

• A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• A61K 38/10 - Peptides having 12 to 20 amino acids
• A61P 31/04 - Antibacterial agents
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals

Abstract

A device for preparation of liquid marbles that has a belt conveyor for carrying a layer of solid particles, the belt conveyor being provided, successively in the direction of movement of the belt with at least one solids dispenser with a reservoir for solid particles, at least one liquid dispenser with a reservoir for liquid, and a separator for separating the prepared liquid marbles from solid particles, is disclosed.

IPC Classes  ?

• B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

The present invention relates to a method for the fast and highly efficient production of multi-component powders by spray drying. The method can be applied to already existing small-scale spray dryers available in the market and enables the production of multiple samples with variable composition in continuous mode. The present invention further relates to an automated device adaptable to small-scale spray drying equipment, consisting of an inlet pumping station (1), a cleaning mechanism (2) for the cyclone, a slide valve (3) adaptable to the cyclone, an autosampler (4), analyser (5), and an automatic control device (6) for the whole apparatus.

IPC Classes  ?

• B01J 2/04 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
• B04B 11/00 - Feeding, charging, or discharging bowls
• F26B 3/12 - Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray
• G01N 1/00 - SamplingPreparing specimens for investigation
• B01D 1/18 - Evaporating by spraying to obtain dry solids

Abstract

A formulation of composites having yeast-derived beta glucan particles (GPs) and water-insoluble or poorly-water-soluble low-molecular-weight compounds, such as medicaments or food supplements is disclosed. The composites can exhibit different crystallinity degrees depending on the formulation and, consequently, dissolution kinetics can be controlled. Yeast-derived beta glucan particles are used as carriers for the encapsulation and amorphization of insoluble or poorly water-soluble low-molecular-weight compounds; amorphous formulations exhibiting faster dissolution rates, and consequently, enhanced oral bioavailability. A method of preparation of the composites by spray drying is also disclosed.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
• C12N 1/18 - Baker's yeastBrewer's yeast

Abstract

1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.

IPC Classes  ?

• C07C 239/20 - Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Abstract

The present invention provides a device for preparation of liquid marbles, which comprises a belt conveyor (1) for carrying a layer of solid particles, said belt conveyor (1) being provided, successively in the direction of movement of the belt, with at least one solids dispenser (2) with a reservoir for solid particles, at least one liquid dispenser (5) with a reservoir (7) for liquid, and a separator for separating the prepared liquid marbles from solid particles.

IPC Classes  ?

• B01J 13/02 - Making microcapsules or microballoons
• B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying
• F28D 20/02 - Heat storage plants or apparatus in generalRegenerative heat-exchange apparatus not covered by groups or using latent heat

Abstract

The present invention provides a device for preparation of liquid marbles, which comprises a belt conveyor (1) for carrying a layer of solid particles, said belt conveyor (1) being provided, successively in the direction of movement of the belt, with at least one solids dispenser (2) with a reservoir for solid particles, at least one liquid dispenser (5) with a reservoir (7) for liquid, and a separator for separating the prepared liquid marbles from solid particles.

IPC Classes  ?

• B01J 13/04 - Making microcapsules or microballoons by physical processes, e.g. drying, spraying
• F28D 20/02 - Heat storage plants or apparatus in generalRegenerative heat-exchange apparatus not covered by groups or using latent heat
• B01J 13/02 - Making microcapsules or microballoons

Abstract

The secondary battery cell (B, B1, B2, B3) is based on glass. Every composite layer (K1.1; K2.1, K2.2; K3.1, K3.2, K3.3) of the cathode (K; K1; K2; K3) or (E1.1; E2.1, E2.2; E3.1, E.2, E3.3) of the electrolyte (E; E1; E2; E3) or (A1.1; A2.1, A2.2; A3.1, A3.2, A3.3) of the anode (A; A1; A2; A3) contains: 0.1 to 10.0% volume of the first additive (A1K; A 1E; A1A) for an increase in electrochemical oxidation-reduction activity of these composite layers; 0.1 to 10.0% volume of the second additive (A2K; A2E; A2A) on the surface of micro- and nanofibres and micro- and nanoparticles for an increase in adhesion of these composite layers; and 80 to 99.8% by volume of selected glass (GMCK; GFIC; GMCA). Each of these composite layers of the cathode (K; K1; K2; K3), electrolyte (E; E1; E2; E3) and anode (A; A1; A2; A3) states a gradual change in the function-gradient concentration of immobile components of composite layers in the direction from the cathode (K) to the anode (A), depending on the distance between the collector (KK) of the cathode (K) and the opposite collector (KA) of the anode (A), and in the inverse direction, and the mobile component in these glass materials (GMCK; GMCA; GFIC) is either the lithium cation Li+or the sodium cation Na+. The claims cover also the method of production of the secondary battery cell (B, B1, B2, B3).

IPC Classes  ?

• H01M 4/04 - Processes of manufacture in general
• H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulatorsProcesses of manufacture thereof
• H01M 4/48 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/04 - Construction or manufacture in general
• H01M 10/052 - Li-accumulators
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 10/0562 - Solid materials
• H01M 10/0585 - Construction or manufacture of accumulators having only flat construction elements, i.e. flat positive electrodes, flat negative electrodes and flat separators
• H01M 50/437 - Glass
• H01M 50/44 - Fibrous material
• H01M 50/443 - Particulate material
• H01M 50/449 - Separators, membranes or diaphragms characterised by the material having a layered structure
• H01M 50/46 - Separators, membranes or diaphragms characterised by their combination with electrodes
• H01M 50/489 - Separators, membranes, diaphragms or spacing elements inside the cells, characterised by their physical properties, e.g. swelling degree, hydrophilicity or shut down properties
• D01D 5/00 - Formation of filaments, threads, or the like
• D01F 1/10 - Other agents for modifying properties
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures
• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/139 - Processes of manufacture
• H01M 50/497 - Ionic conductivity
• D01D 5/28 - Formation of filaments, threads, or the like while mixing different spinning solutions or melts during the spinning operationSpinnerette packs therefor
• D01D 10/02 - Heat treatment
• D04H 3/002 - Inorganic yarns or filaments
• H01M 4/136 - Electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy

Abstract

Date de soumission / Date Submitted: 2021/09/23No de la demande can. / CA App. No.: 3131583Abrégé:La présente invention concerne une forrnulation de cornposites comprenant des particules de bêta-glucane dérivées de levure (GPs) et des cornposés de faible poids moléculaire insolubles ou peu solubles dans l'eau, tels que des rnédicarnents ou des suppléments alimentaires. Les cornposites peuvent présenter différents degrés de cristallinité en fonction de la formulation et, par conséquent, la cinétique de dissolution peut être régulée. Des particules de bita-glucane dérivées de levure sont utilisées en tant qu'excipients pour l'encapsulation et l'amorphisation de composés de faible poids rnoléculaire insolubles ou peu solubles dans l'eau ; des forrnulations arnorphes présentant des vitesses de dissolution plus rapides, et par conséquent, une biodisponibilité orale améliorée. L'invention concerne égalernent un procédé de préparation des cornposites par séchage par pulvérisation ainsi que son utilisation.Abstract:The present invention relates to a formulation of composites cornprised of yeast-derived beta glucan particles (GPs) and water-insoluble or poorly-water-soluble low-rnolecular-weight cornpounds, such as medicaments (drugs) or food supplernents. The composites can exhibit different crystallinity degrees depending on the formulation and, consequently, dissolution kinetics can be controlled. Yeast-derived beta glucan particles are used as carriers for the encapsulation and amorphization of insoluble or poorly-water-soluble low-molecular-weight compounds; amorphous formulations exhibiting faster dissolution rates, and consequently, enhanced oral bioavailability. The present invention further relates to a rnethod of preparation of the composites by spray drying, and the use thereof.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

Abstract

The present invention relates to a formulation of composites comprised of yeast-derived beta glucan particles (GPs) and water-insoluble or poorly-water-soluble low-molecular-weight compounds, such as medicaments (drugs) or food supplements. The composites can exhibit different crystallinity degrees depending on the formulation and, consequently, dissolution kinetics can be controlled. Yeast-derived beta glucan particles are used as carriers for the encapsulation and amorphization of insoluble or poorly-water-soluble low-molecular-weight compounds; amorphous formulations exhibiting faster dissolution rates, and consequently, enhanced oral bioavailability. The present invention further relates to a method of preparation of the composites by spray drying, and the use thereof.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 31/00 - Medicinal preparations containing organic active ingredients

Goods & Services

Pamphlets; Informational letters; Catalogues; Flyers; Visiting cards; Invitation cards; Events programmes; Promotional publications; Study guides; Printed questionnaires; Printed leaflets; Printed news releases; Educational publications. Advertising; Public relations services. Dissemination of educational material; Education and instruction services; Arranging and conducting of seminars and workshops; Publication and editing of printed matter; Electronic publishing services; Organisation of seminars.

Abstract

The electrodes, anode (A) as well as cathode (K), are electronically and ionically conductive, contain solid amorphous glass composite material and also glass and/or metallic fibres and glass and/or crystalline particles with a mean diameter in nano/micrometres from 1 nm to 100 μm. Their surface is nano/micro-structural with mean roughness from 1 nm to 100 μm; and contains, as ionic charge carriers, migrating lithium and/or sodium cations for migration from the anode (A) through the electrolyte (E) to the cathode (K) during discharging of the secondary battery cell (B) and from the cathode (K) to the anode (A) during recharging of the secondary battery cell (B). The electrolyte (E) is ion-conducting, it contains solid amorphous glass composite material with lithium and/or sodium cations as the ionic charge carriers. The composition of the glass for the electrodes (A, K) as well as electrolyte (E) and their conductivity are claimed. The composite material of the electrodes (A, K) contains active oxidation-reduction centres based on metallic silicon and/or silicon oxides and/or glasses containing electropositive polyvalent elements Mp, where these oxidation-reduction centres have the ratio of the higher oxidation state to the lower oxidation state of polyvalent elements Mp from 0.1 to 10, and thus also create gradient nano/micro composite glass material of the electrodes (A, K) with mixed ionic and electron conductivity. The oxidation-reduction centres have polyvalent elements Mp which for the assurance of reversible oxidation- reduction reactions are able to,transfer their oxidation states.

IPC Classes  ?

• H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/136 - Electrodes based on inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFy
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/48 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 10/052 - Li-accumulators
• H01M 10/0562 - Solid materials
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium

Abstract

The invention provides a method for recovering lithium and optionally further alkali metal compounds, a mineral from the group of phyllosilicates containing lithium and optionally further alkali metals and also at least 0.2 wt. %, preferably at least 0.9 wt. %, of fluorine, is subjected to a thermal treatment in a furnace at a temperature within the range of from 1100 °C to 1700 °C, preferably at a temperature within the range of from 1220 °C to 1700 °C, at a pressure within the range of from 20 kPa to 150 kPa for a period of 15 to 360 minutes, in the presence of a reagent which contains a) at least one substance from a group comprising carbonates, oxides, hydroxides, sulfates, sulfites and chlorides of alkaline earth metals, in particular calcium; and b) at least one substance capable of releasing chlorine and/or hydrogen chloride and/or sulfur trioxide and/or sulfur dioxide during the thermal treatment, wherein the molar ratio of the total amount of sulfur trioxide and/or sulfur dioxide expressed as S03 and/or of chlorine and/or hydrogen chloride expressed as Cl2 to the total amount of alkali metals including lithium, released from the silicate mineral in the reaction space in the furnace, is at least 0.5, the content of alkaline earth metals, in particular calcium, recalculated as the their oxide content, in the mixture of the phyllosilicate mineral with the reagent is at least 20 wt. %, and the fluorine content in the mixture of the phyllosilicate mineral with the reagent is from 0.1 to 2 wt. %, preferably from 0.2 to 2 wt. %, for decomposition of the structure of the phyllosilicate mineral and for volatilization of lithium compounds and optionally further alkali metal compounds from the thermally treated phyllosilicate mineral, and the compounds of lithium and optionally of further alkali metals are subsequently recovered by condensation by drawing off from 50 to 100 vol. % of flue gas formed in the furnace from the furnace from one or more different places having different temperatures., wherein the rate and volume of the drawn off flue gases from different places can be different for the selective recovery of compounds of individual alkali metals or their groups.

IPC Classes  ?

• C01D 1/00 - Oxides or hydroxides of sodium, potassium, or alkali metals in general
• C01D 3/00 - Halides of sodium, potassium, or alkali metals in general
• C01D 15/00 - Lithium compounds
• C04B 7/36 - Manufacture of hydraulic cements in general

Abstract

The invention provides a method for recovering lithium and optionally further alkali metal compounds, a mineral from the group of phyllosilicates containing lithium and optionally further alkali metals and also at least 0.2 wt. %, preferably at least 0.9 wt. %, of fluorine, is subjected to a thermal treatment in a furnace at a temperature within the range of from 1100 °C to 1700 °C, preferably at a temperature within the range of from 1220 °C to 1700 °C, at a pressure within the range of from 20 kPa to 150 kPa for a period of 15 to 360 minutes, in the presence of a reagent which contains a) at least one substance from a group comprising carbonates, oxides, hydroxides, sulfates, sulfites and chlorides of alkaline earth metals, in particular calcium; and b) at least one substance capable of releasing chlorine and/or hydrogen chloride and/or sulfur trioxide and/or sulfur dioxide during the thermal treatment, wherein the molar ratio of the total amount of sulfur trioxide and/or sulfur dioxide expressed as S03 and/or of chlorine and/or hydrogen chloride expressed as Cl2 to the total amount of alkali metals including lithium, released from the silicate mineral in the reaction space in the furnace, is at least 0.5, the content of alkaline earth metals, in particular calcium, recalculated as the their oxide content, in the mixture of the phyllosilicate mineral with the reagent is at least 20 wt. %, and the fluorine content in the mixture of the phyllosilicate mineral with the reagent is from 0.1 to 2 wt. %, preferably from 0.2 to 2 wt. %, for decomposition of the structure of the phyllosilicate mineral and for volatilization of lithium compounds and optionally further alkali metal compounds from the thermally treated phyllosilicate mineral, and the compounds of lithium and optionally of further alkali metals are subsequently recovered by condensation by drawing off from 50 to 100 vol. % of flue gas formed in the furnace from the furnace from one or more different places having different temperatures., wherein the rate and volume of the drawn off flue gases from different places can be different for the selective recovery of compounds of individual alkali metals or their groups.

IPC Classes  ?

• C01D 1/00 - Oxides or hydroxides of sodium, potassium, or alkali metals in general
• C01D 3/00 - Halides of sodium, potassium, or alkali metals in general
• C01D 15/00 - Lithium compounds
• C04B 7/36 - Manufacture of hydraulic cements in general

Abstract

The invention provides methods for imaging biological tissue. The disclosed polymethenium salts show activity as two photon imaging agents, having a greater imaging depth and photostability than known agents, whilst having lower toxicity. The methods show great selectivity for mitochondria. The methods have utility in both in vitro and in vivo imaging, for example, imaging of tumours.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• A61K 49/00 - Preparations for testing in vivo
• C07D 401/00 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
• C07D 417/00 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group
• C09B 23/01 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain
• C09B 23/08 - Methine or polymethine dyes, e.g. cyanine dyes characterised by the methine chain containing an odd number of CH groups more than three CH groups, e.g. polycarbocyanines

Abstract

New aminooxylipids of general formula (I), wherein n1 = 5-30 and X is polymethylene linker of the general formula (II) where n2 = 2 -10, or X is polyethylene glycol linker of the general formula (III), wherein n3 = 1-14, are provided. A method of preparation of the aminooxylipids of general formula (I) characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C-0-(C=0)-HN-(CH2)n-N H2, n = 2 -13}, or N-tert- butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C-0-(C=0)-HN-(CH2)2-[0-(CH2)]n-0-(CH2)2NH2, n = 1-14} with in position C(2) symmetrically branched fatty acids of general formula (IV), wherein n1 = 5-30, in the presence of condensation reagent, or from acid of general formula (IV) derived acylchloride of general formula (V) wherein n1 = 5-30, produces N-Boc-aminolipids of general formula (VI), wherein n1 = 5-30 a X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). These are converted by debocylation to aminolipids of general formula (VII), wherein n1 = 5-30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). By their condensation with N-terf-butoxycarbonyl-aminooxyacetic acid in the presence of condensation reagent, N-Boc-aminooxylipids of general formula (VIII), where in n1 = 5- 30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III), are obtained, which by debocylation afford aminooxylipids of general formula (I). Acylchlorides of general formula (V) are prepared by reaction of acid of general formula (IV) with oxalylchloride in the presence of catalytic amount of N, N-dimethylformamide in organic aprotic solvent. The use of nontoxic aminooxylipids of the general formula I for construction of nontoxic self-assembly liposomal carriers of therapeutics presenting aminooxy groups and so-called "post-liposomal" modification of these carriers with biologically functional molecules using oxime ligation technique (binding counterparts: aminooxy group and aldehyde or ketone group).

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
• C07C 235/08 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
• C07C 235/10 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups

Abstract

New aminooxylipids of general formula (I), wherein n1 = 5-30 and X is polymethylene linker of the general formula (II) where n2 = 2 -10, or X is polyethylene glycol linker of the general formula (III), wherein n3 = 1-14, are provided. A method of preparation of the aminooxylipids of general formula (I) characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C-0-(C=0)-HN-(CH2)n-N H2, n = 2 -13}, or N-tert- butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C-0-(C=0)-HN-(CH2)2-[0-(CH2)]n-0-(CH2)2NH2, n = 1-14} with in position C(2) symmetrically branched fatty acids of general formula (IV), wherein n1 = 5-30, in the presence of condensation reagent, or from acid of general formula (IV) derived acylchloride of general formula (V) wherein n1 = 5-30, produces N-Boc-aminolipids of general formula (VI), wherein n1 = 5-30 a X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). These are converted by debocylation to aminolipids of general formula (VII), wherein n1 = 5-30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). By their condensation with N-terf-butoxycarbonyl-aminooxyacetic acid in the presence of condensation reagent, N-Boc-aminooxylipids of general formula (VIII), where in n1 = 5- 30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III), are obtained, which by debocylation afford aminooxylipids of general formula (I). Acylchlorides of general formula (V) are prepared by reaction of acid of general formula (IV) with oxalylchloride in the presence of catalytic amount of N, N-dimethylformamide in organic aprotic solvent. The use of nontoxic aminooxylipids of the general formula I for construction of nontoxic self-assembly liposomal carriers of therapeutics presenting aminooxy groups and so-called "post-liposomal" modification of these carriers with biologically functional molecules using oxime ligation technique (binding counterparts: aminooxy group and aldehyde or ketone group).

IPC Classes  ?

• C07C 235/08 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• C07C 235/10 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
• A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates

Abstract

The present invention relates to photoactivatable nanoparticles for photodynamic applications containing a photosensitizer, a (C8 to C22) fatty alcohol and a polymeric surfactant, preferably poly(ethylene oxide) monomethyl ether-block-poly(ε-caprolactone), whereas the size of the nanoparticle is in the range of from 1 to 1000 nm, and the core of the nanoparticle is solid at the temperature of 4 °C, and liquid at the temperature around 39 °C. The present invention further relates to a method of preparation of the photoactivatable nanoparticle, a pharmaceutical composition containing it, and use thereof.

IPC Classes  ?

• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Antineoplastic agents

Abstract

− independently represent anions of pharmaceutically acceptable salts.

IPC Classes  ?

• C07D 471/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups in which the condensed systems contains four or more hetero rings
• A61K 31/475 - QuinolinesIsoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention provides new strains of lactobacilli, producing substances effective against vaginal pathogens, Lactobacillus crispatus CCM 7997; Lactobacillus reuteri CCM 7998; Lactobacillus crispatus CCM 8522; Lactobacillus fermentum CCM 8523. These new strains of lactobacilli are suitable for the prevention and/or treatment of chronic urogenital infections, restoration of natural vaginal microflora, and/or for elimination of discomfort of women during pre-menstrual and menstrual period. They can be used as active ingredients in medicaments or in sanitary products.

IPC Classes  ?

• A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
• A61P 15/02 - Drugs for genital or sexual disordersContraceptives for disorders of the vagina
• A61P 13/00 - Drugs for disorders of the urinary system
• A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
• C12N 1/20 - BacteriaCulture media therefor

Abstract

The invention relates to a method of isolation of polyhydroxyalkanoates from biomass containing polyhydroxyalkanoates comprising the steps of extracting components of the biomass other than polyhydroxyalkanoates from the biomass by means of an extraction agent based on alkyl alcohol having 2 to 4 carbon atoms in the chain, separating the extract containing these components from the extraction solution thus obtained, removing the remainder of the extraction agent from the solid phase by distillation with an aqueous solution or by stripping with water vapour or by drying, extracting from the solid phase thus pre-cleaned polyhydroxyalkanoates by an extraction agent based on chlorinated hydrocarbon, separating the polyhydroxyalkanoates from the extraction solution thus obtained, and feeding this extract to a circulation loop in order to obtain a polyhydroxyalkanoates precipitate.

IPC Classes  ?

• C08G 63/90 - PurificationDrying
• C12P 7/62 - Carboxylic acid esters

Abstract

The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C4 alkyl, up to three of S1,2, S1',2', S3,4 and S3',4' are present, each of S1,2, S1',2', S3,4 and S3',4' independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, preferably hydrocarbon chain having 4 carbon atoms, more preferably hydrocarbon chain having 4 carbon atoms and two double bonds, and one to four atoms selected from the carbon atoms with the descriptor 2, 4, 2', and 4' are substituted with a substituent R3 of general formula II, wherein R4 is substituted or unsubstituted heteroaryl, T1 and T2 are independent linkers that bridge atoms N5 with C8 and N5´ with C8´, wherein T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, preferably 2 or 3 carbon atoms; and anions (X1 )- and (X2 )- independently represent anions of pharmaceutically acceptable salts. The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases and in the treatment, requiring affecting of G-quadruplex, preferably at telomeres or in gene promoters. ˙

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention relates to the method of preparation of a soluble block copolymer poly(styrene-block-C2-C4alkylene-stat-C2-C4alkylene-block-styrene) chloromethylated into a chloromethylation degree higher than 35 %. The principle of this method lies in a reaction of the starting block copolymer poly(styrene-block-C2-C4alkylene-stat-C2-C4alkylene-block-styrene) with dimethoxymethane, a chlorinating agent, and ZnCl2 catalyst, preferably at the temperature in the range of from 10 °C to 65 °C, with no direct use of chloroalkyl ethers and with no side cross-linking reaction. The invention further describes the use of this method for the preparation of homogeneous or microheterogeneous anion-exchange membranes, particularly by chloromethylated solution casting, its reaction with trialkylamine or trialkylphosphine, and their use for electrode impregnation in electrochemical devices, as catalyst carriers, for preparation of ion-exchange membranes and binders in electrochemical devices, ion-exchange applications and catalytic systems.

IPC Classes  ?

• B01J 47/12 - Ion-exchange processes in generalApparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
• B01D 71/82 - Macromolecular material not specifically provided for in a single one of groups characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
• C08J 5/22 - Films, membranes or diaphragms
• C08F 8/24 - Haloalkylation

Abstract

Device for elimination of gaseous noxious substances from an air mass, comprising: - an incineration module (2) having an inlet orifice for feeding the air mass and an outlet orifice for exhausting the air mass, - at least one heating wire (5) arranged inside the incineration module (2), and - a regulating unit that is interconnectable the heating wire (5) and adapted for adjusting the temperature of the heating wire.

IPC Classes  ?

• B01D 53/44 - Organic components
• B01D 53/72 - Organic compounds not provided for in groups , e.g. hydrocarbons
• B01D 53/00 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols
• F01N 3/26 - Construction of thermal reactors

Abstract

Energy sources, such as industrial glass burners (11), heating electrodes (10) and other suitable heating energy sources operate on the molten glass melt (6) containing undissolved particles, especially glass sand and bubbles, in the longitudinal axis of the melting space, or in a direction parallel with this longitudinal axis, until creation of one or more longitudinal temperature barriers in the glass melt (6) and until the arising of the cross temperature gradient [K.m-1] which generates spiral-type flowing of the glass melt (6) with a rotary movement across the melting space, and in fact perpendicularly to the longitudinal axis of the melting part. This spiral-type flowing proceeds in the direction from the front wall (2) to the submerged cross refractory barrier (7) in the glass melt (6), or in the direction from the front wall (2) to the cross row (9) of the energy sources. The transversal temperature gradient [K.m-1] of each spiral-type flowing is always set as higher than longitudinal temperature gradient [K.m-1] between the front wall (2) and the submerged cross refractory barrier (7) in the glass melt (6), or between the front wall (2) and the cross row (9) of the energy sources, as a consequence of which it is possible to utilise 0.6 to 0.8 multiple of the total melting space. The ratio of the cross temperature gradient [K.m-1] to the longitudinal temperature gradient [K.m-1] is higher than 1 and lower than 30, preferably it is within the range from 5 to 20. Energy sources, such as heating electrodes (10) and/or industrial glass burners (11) in the melting space are arranged for creation of one or more longitudinal temperature barriers in the glass melt (6) and for generation of the spiral-type flowing of glass melt (6) with a rotary movement across the melting part, in fact perpendicularly to the longitudinal axis of the melting part, and for the setting of the cross temperature gradient [K.m-1] of the spiral-type flowing higher than the longitudinal temperature gradient [K.m-1].

IPC Classes  ?

• C03B 5/183 - Stirring devicesHomogenisation using thermal means, e.g. for creating convection currents
• C03B 5/185 - Electric means

Abstract

The invention relates to a method of anchoring nanostructures (5) of gold on the surface of the base material (1). First, chemical bonds on the surface of the base material (1) are split by action of high - energetic particles, while at least portion of radicals (2) and/or conjugated double bonds (3) created by this way spontaneously oxides by contact with atmosphere to obtain oxygenous groups. Afterwards, the radicals (2) and/or double bonds (3) and/or oxygenous groups on surface of the base material (1) by means of chemical reaction between them and mercapto group (-SH) or amino group (-NH2) or hydroxyl group (-0H), molecules of dithiol and/or thiol are bonded. Subsequently by means of chemical reaction between their unsaturated mercapto group (-SH) and gold, nanostructures of gold are bonded, being thus anchored on surface of the base material (1). The method can also be used for anchoring layer of gold. The invention also relates to a substrate prepared by these methods.

IPC Classes  ?

• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate

Abstract

The invention relates to a method for anchoring carbon nanoparticles onto surface of a base material, by which chemical bond based on amino group (-NH2), resp. physical bond based on an organic substance containing mercapto group (-SH) and/or hydroxy group (-OH) and/or amino group (-NH2) is created between surface of the base material and carbon nanoparticles. The inventions also relates to a substrate comprising base material and layer of carbon nanoparticles, which is anchored to the base material by chemical bond based on amino group (-NH2), resp. by physical bond based on an organic substance containing mercapto group (-SH) and/or hydroxyl group (-OH) and/or amino group (-NH2).

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The method for brown coal coke production is based on the fact that brown coal with carbon content in dry matter of 60 to 75% by weight, volatile matter 40 to 60% by weight and tar 17.5 to 30% by weight is by crushing and grinding modified to the grain-size of under 0.25 mm, moistened to the total water content ranging between 10 and 25% by weight; the homogenised mixture is placed in the retort, and after its compacting it is indirectly heated to the internal temperature of the retort between 950 to 1300°C and kept at this temperature for 2 hours or more. The product is subsequently removed from the retort after cooling to the surface temperature of 400°C.

IPC Classes  ?

• C10L 9/08 - Treating solid fuels to improve their combustion by heat treatment, e.g. calcining
• C10B 57/04 - Other carbonising or coking processesFeatures of destructive distillation processes in general using charges of special composition