Produits et services

Medical laboratory services; medical and scientific research; providing medical testing services; providing information about medical research; research for development of pharmaceuticals and treatments; providing information for use in medical research Medical assistance; medical consultations; medical counseling; medical information; medical screening; medical services; human tissue bank services; biomedical services, namely, the storage of human cells, human tissue, human blood and human saliva for medical use; storage of biological samples

Produits et services

Online medical consultations rendered in virtual environments; telemedicine services; pediatric health care services; nursing services

Abrégé

Embodiments of the present disclosure pertain to a composition with molecules that self-assemble to form a particle. Additional embodiments of the present disclosure pertain to methods of imaging a region of a subject by: (1) administering the compositions of the present disclosure to the subject to result in the accumulation of the molecules in the region of the subject; and (2) imaging the region of the subject. In some embodiments, the imaged region includes a tumor. In some embodiments, the imaged region includes a blood vessel.

Classes IPC  ?

• A61K 49/00 - Préparations pour examen in vivo

Produits et services

Charitable services, namely, business administration and management of global healthcare programs; advertising services to promote public awareness of global healthcare programs via public health campaigns and community outreach programs; charitable services, namely, business administration and management of programs through a network of outreach centers that aim to implement best practices, support government health initiatives, and maximize public health impacts throughout the world; charitable services, namely, providing business administration and management of healthcare facilities and personnel. Construction of medical centers focused on patient care, education, research, and healthcare management. Medical training and teaching, namely, training of local healthcare workers including pathologists, nurses, pharmacists. Medical research; medical research in the field of epidemiology; vaccine research and development. Pediatric health care services; medical patient care; medical clinic services.

Abrégé

A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: wherein X is —CH2—, —CH2—CH2—, —CHO—, or —O—CO—; Y is —CH—CH═CH— or A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: wherein X is —CH2—, —CH2—CH2—, —CHO—, or —O—CO—; Y is —CH—CH═CH— or A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: wherein X is —CH2—, —CH2—CH2—, —CHO—, or —O—CO—; Y is —CH—CH═CH— or A and B are independently selected from C and N; R1, R2, R3, and R4 are independently selected from —H, halogen, —OH, and —CH3; and R5, R6, and R7 are independently selected from —H, halogen, —OH, —OCH3, —NO2, —N(CH3)2, C1-C6 alkyl, or a substituted or unsubstituted C4-C6 aryl group, except that when A and/or B is N the adjacent R5 and/or R7 is —H, or a pharmaceutically acceptable salt thereof.

Classes IPC  ?

• A61K 49/08 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par le support
• C07C 49/755 - Composés non saturés comportant un groupe cétone faisant partie d'un cycle contenant des groupes éther, des groupes , des groupes ou des groupes un groupe cétone faisant partie d'un système cyclique condensé de deux ou trois cycles, un des cycles au moins étant un cycle aromatique à six chaînons
• C07C 65/40 - Composés comportant des groupes carboxyle liés à des atomes de carbone de cycles aromatiques à six chaînons et contenant l'un des groupes OH, O-métal, —CHO, cétone, éther, des groupes , des groupes ou des groupes contenant des groupes cétone contenant des groupes avec de l'oxygène lié par liaison simple
• C07D 333/22 - Radicaux substitués par des hétéro-atomes liés par une liaison double ou par deux hétéro-atomes, autres que des halogènes, liés au même atome de carbone par des liaisons simples
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61K 49/10 - Composés organiques

Produits et services

Emergency medical services; Health care; Health counseling; Hospital services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Nutrition counseling; Pediatric health care services; Physical therapy; Physician services; Psychological assessment services; Psychological consultation; Psychological counseling; Psychological testing; obstetric and gynecology services; human fertility treatment services; genetic counseling

Produits et services

Pediatric healthcare services; Emergency medical services; Health care; Health counseling; Hospital services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Nutrition counseling; Pediatric health care services; Physical therapy; Physician services; Psychological assessment services; Psychological consultation; Psychological counseling; Psychological testing

Produits et services

Administration of healthcare plans; organizing healthcare plans; providing information about healthcare insurance plans; underwriting and administration of healthcare plans Arranging for and providing managed healthcare services, namely, health care in the nature of health maintenance organizations

Abrégé

Methods and compositions for detecting tau pathology are described. The compositions for detecting tau pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.

Classes IPC  ?

• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique

Abrégé

Methods and compositions for detecting tau pathology are described. The compositions for detecting tau pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider

Abrégé

Improved nasopharyngeal swabs for COVID-19 or other molecular diagnostic testing are discussed herein. Swab designs for adult use are not suitable for pediatric use. Swabs for pediatric use need to be smaller and more flexible to navigate delicate pediatric nasopharyngeal cavities. A novel use of maxillofacial CT scans to aid in the design of pediatric nasopharyngeal swabs satisfying such criteria is discussed. Further, the novel swabs are also suitable for 3D printing.

Classes IPC  ?

• A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie

Produits et services

Educational services for pediatric patients, namely, providing a mock simulator program and educational materials in connection therewith in preparation for imaging and radiology procedures

Produits et services

Accepting and administering monetary charitable contributions to fund medical research; Charitable fundraising; providing fundraising activities to support medical research and procedures Medical training and teaching; providing classes, workshops, seminars, conferences, and training in the field of medical research and treatment Multidisciplinary research of neurological disorders, namely, pediatric studies of the brain structure, development patterns and related neurological diseases; medical and scientific research services in the field of neurological disorders Health care; Medical services; Pediatric health care services; medical evaluation and treatment of neurological diseases and disorders; providing medical care in the field of neurological diseases and disorders

Produits et services

Accepting and administering monetary charitable contributions to fund medical research; Charitable fundraising; providing fundraising activities to support medical research and procedures

Produits et services

T-shirts; headwear; sweatshirts; polo shirts; jackets. Charitable fundraising services. Medical training and teaching; educational services, namely, conducting seminars, lectures, meetings, symposiums in the fields of medicine and research and distributing course materials in connection therewith; training of clinicians and scientists in the field of pediatric research; development and dissemination of educational materials in the field of medicine. Medical laboratories; medical and scientific research; providing medical testing services; providing information about medical research. Pediatric health care services; medical assistance; medical consultations; medical counseling; medical information; medical screening; medical services; nursing, medical; emergency medical services; health care; health counseling; hospital services; nutrition counseling; physical therapy; physician services; behavioral health services; providing health information; providing health information via electronic communication networks; providing information on health, wellness and nutrition via a website; providing information for patients in the field of health via a website.

Produits et services

Providing information in the field of childhood literacy; educational services, namely, conducting programs, in the field of childhood literacy, reading schedules, and children books Providing medical information in the field of infant cognitive development; providing medical information in the field of speech and language pathology

Abrégé

Embodiments of the present disclosure pertain to methods of assessing the severity of an inflammatory condition in a subject by receiving certain biomarker levels in the subject and assessing the severity of the inflammatory condition based on the measured biomarker levels. Differentially expressed levels of certain biomarkers may be correlated to a likelihood of developing a severe inflammatory condition while differentially expressed levels of other biomarkers may be correlated to a likelihood of developing a non-severe inflammatory condition. The methods of the present disclosure may also include a step of making a treatment decision based on the assessment of the severity of the inflammatory condition, such as monitoring the course of the inflammatory condition and/or administering a therapeutic agent to the subject. The method may be repeated after implementing a treatment decision in order to further assess the severity of the inflammatory condition after the treatment decision.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet

Produits et services

Organizing and developing global healthcare charitable projects that aim to provide healthcare facilities, healthcare services, medical training, medical research, and support for government health initiatives on an international basis; Promoting public awareness of global healthcare programs via public health campaigns and community outreach programs; Charitable services, namely, organizing and developing programs through a network of outreach centers that aim to implement best practices, support government health initiatives, and maximize public health impacts throughout the world; Charitable services, namely, providing business administration and management of healthcare facilities and personnel Construction of medical centers focused on patient care, education, research, and healthcare management Medical training and teaching, namely, training of local healthcare workers including pathologists, nurses, pharmacists Medical research; Medical research in the field of epidemiology; Vaccine research and development Pediatric health care services; Medical patient care; medical clinic services

Produits et services

Medical and scientific research information in the field of congenital heart disease; conducting medical research in the field of congenital heart disease and medical devices Medical clinic services; Healthcare services, namely, wellness and therapeutic programs in the field of congenital heart disease; surgery in the field of congenital heart disease

Produits et services

Administration, billing and reconciliation of accounts on behalf of others; Medical billing; Medical billing support services Accepting and administering monetary charitable contributions; Charitable fundraising; Charitable services, namely, providing financial assistance to meet the physical, psychological, social and other special needs of children; Insurance claims processing; Insurance information and consultancy Medical training and teaching; Consultancy in the field of learning difficulties; Educational services, namely, conducting seminars, lectures, meetings, symposiums in the fields of medicine and research and distributing course materials in connection therewith; training of clinicians and scientists in the field of pediatric research; development and dissemination of educational materials in the field of medicine Medical laboratories; Medical research Charitable services, namely, providing vision screenings; Emergency medical services; Health care; Health counseling; Hospital services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Nutrition counseling; Optometry services; Pediatric health care services; Physical therapy; Physician services; Psychological assessment services; Psychological consultation; Psychological counseling; Psychological testing; Providing hearing screening services; providing health information; providing health information via electronic communication networks; providing a website featuring information on health, wellness and nutrition; providing a website featuring information for patients in the field of health Providing personal support services for patients and families of patients, namely, emotional counseling and emotional support; Spiritual counseling

Produits et services

Administration, billing and reconciliation of accounts on behalf of others; Medical billing; Medical billing support services Insurance claims processing; Insurance information and consultancy Medical laboratories Urgent medical care centers; Health care; Health counseling; Hospital services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Nutrition counseling; Pediatric health care services; Physician services; Psychological assessment services; Psychological consultation; Psychological testing; providing health information; providing health information via electronic communication networks; providing a website featuring information on health, wellness and nutrition; providing a website featuring information for patients in the field of health

Produits et services

Vaccine preparations. T-shirts, shirts, hats, caps. Vaccine research and development; providing information about medical and scientific research in the field of vaccine development and the prevention and treatment of COVID-19.

Abrégé

Methods and compositions for detecting tau pathology are described. The compositions for detecting tau pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique

Abrégé

A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: 2—, —CHO—, or —O—CO—; Y is —CH—CH═CH— or 7 is —H, or a pharmaceutically acceptable salt thereof.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 49/08 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par le support
• C07C 49/755 - Composés non saturés comportant un groupe cétone faisant partie d'un cycle contenant des groupes éther, des groupes , des groupes ou des groupes un groupe cétone faisant partie d'un système cyclique condensé de deux ou trois cycles, un des cycles au moins étant un cycle aromatique à six chaînons
• C07C 65/40 - Composés comportant des groupes carboxyle liés à des atomes de carbone de cycles aromatiques à six chaînons et contenant l'un des groupes OH, O-métal, —CHO, cétone, éther, des groupes , des groupes ou des groupes contenant des groupes cétone contenant des groupes avec de l'oxygène lié par liaison simple
• C07D 333/22 - Radicaux substitués par des hétéro-atomes liés par une liaison double ou par deux hétéro-atomes, autres que des halogènes, liés au même atome de carbone par des liaisons simples
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61K 49/10 - Composés organiques

Produits et services

Charitable fundraising services Medical training and teaching; Educational services, namely, conducting seminars, lectures, meetings, symposiums in the fields of medicine and research and distributing course materials in connection therewith; training of clinicians and scientists in the field of pediatric research; development and dissemination of educational materials in the field of medicine Medical laboratories; Medical and scientific research; providing medical testing services; providing information about medical research Pediatric health care services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Emergency medical services; Health care; Health counseling; Hospital services; Nutrition counseling; Physical therapy; Physician services; behavioral health services; providing health information; providing health information via electronic communication networks; providing a website featuring information on health, wellness and nutrition; providing a website featuring information for patients in the field of health

Abrégé

A liposomal composition (“ADx-001”) is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid.

Classes IPC  ?

• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 49/10 - Composés organiques
• A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides

Produits et services

Vaccine research and development; providing information about medical and scientific research in the field of vaccine development

Produits et services

Vaccine preparations T-shirts, shirts, hats and baseball caps Providing information about the prevention and treatment of COVID-19

Produits et services

Educational services, namely, conducting classes in the field of pediatrics and distributing course materials in connection therewith; educational demonstrations in the field of pediatrics; teaching in the field of pediatrics Medical research services; medical laboratory services Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospitals; medical services; nutritional counseling; physical therapy services; physician services; psychological testing; providing health care information by telephone

Abrégé

2221234356732321646577 is -H, or a pharmaceutically acceptable salt thereof.

Classes IPC  ?

• A61K 49/06 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM]
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes

Abrégé

A liposomal composition (“ADx-001”) is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid.

Classes IPC  ?

• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
• A61K 49/10 - Composés organiques

Abrégé

A liposomal composition ("ADx-001") is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid.

Classes IPC  ?

• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 49/06 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM]
• A61K 49/16 - AnticorpsImmunoglobulinesLeurs fragments

Abrégé

Disclosed herein is a composition comprising a plurality of liposomes having an average diameter of less than 400 nanometers, wherein the plurality of liposomes comprise: a first lipid or phospholipid; a second lipid or phospholipid which is derivatized with a polymer; and a sterically bulky excipient capable of stabilizing the liposomes; a third lipid or phospholipid derivatized with a polymer terminated with an integrin targeting component; DSPE or a fourth lipid or phospholipid derivatized with a group binding a contrast enhancing agent wherein the plurality of liposomes optionally encapsulates a payload component consisting of one or more bioactive agents.

Classes IPC  ?

• C07D 213/69 - Au moins deux atomes d'oxygène
• A61K 49/00 - Préparations pour examen in vivo
• A61K 49/10 - Composés organiques
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes

Abrégé

Methods and compositions for detecting tau pathology are described. The compositions for detecting tan pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.

Classes IPC  ?

• C12Q 1/6811 - Méthodes de sélection pour la production ou l’élaboration d’oligonucléotides spécifiques cibles ou de molécules de liaison
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider

Produits et services

Medical trainer kit comprised of an artificial skin and tissue model for medical instruction purposes

Abrégé

Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid-polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 49/00 - Préparations pour examen in vivo
• A61K 49/10 - Composés organiques
• A61K 49/12 - Composés macromoléculaires

Abrégé

Skeletal age determination using neural networks can use images of only a portion of a patient's hand. For example, rather than train a neural network using entire hand radiographs, the neural network may be trained with radiographs of only digits of the hand, a few digits of the hand, or a single digit of the hand. The neural network can then be used to process radiographs of a patients' digit or digits to obtain a skeletal maturity for the patient. Processing radiographs of individual digits rather than entire hands allows lower-quality (e.g., higher noise) radiographs, such as low-dose radiographs, to be used to accurately determine skeletal maturity.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/107 - Mesure de dimensions corporelles, p. ex. la taille du corps entier ou de parties de celui-ci
• A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations

Produits et services

Charitable fundraising services by means of organizing and conducting fundraising events; Charitable fundraising services for pediatric medical research and treatment programs; charitable fundraising services by means of entertainment events

Abrégé

Certain embodiments of the invention are directed to methods of adjusting the concentration of one or more electrolytes in a patient's blood using a counter current electrolyte solution.

Classes IPC  ?

• A61M 1/14 - Systèmes de dialyseReins artificielsOxygénateurs du sang
• A61M 1/16 - Systèmes de dialyseReins artificielsOxygénateurs du sang avec membranes
• A61M 1/36 - Autre traitement du sang dans une dérivation du système circulatoire naturel, p. ex. adaptation de la température, irradiation

Abrégé

The present invention is directed towards new chemical entities based on a lipid-paramagnetic metal ion chelate. The lipid portion of the compound intercalates into the membrane of a liposome. The compounds of the invention find particular use as paramagnetic contrast media for magnetic resonance imaging. It has been surprisingly discovered that the liposomal contrast media do not substantially cross the placental barrier into the vasculature of the fetus(es) when administered to a pregnant subject. These novel compounds are useful in the diagnosis of disorders and diseases in both gravid and non-gravid subjects. The invention is also directed towards pharmaceutical compositions comprising these compounds and the uses of these compounds.

Classes IPC  ?

• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 49/10 - Composés organiques
• C07F 5/00 - Composés contenant des éléments des groupes 3 ou 13 du tableau périodique

Produits et services

Medical training and teaching, namely, training of local healthcare workers including pathologists, nurses, pharmacists; delivery of state-of-the-art care for children; train local healthcare workers including pathologists, nurses, pharmacists; conduct public health campaigns and community outreach programs to increase awareness; establish centers focused on patient care, education, research, and healthcare management; develop a network of centers to implement best practices throughout Africa and the world.

Produits et services

Charitable fundraising; On-line charitable fundraising

Abrégé

Disclosed herein is a composition comprising a plurality of liposomes having an average diameter of less than 400 nanometers, wherein the plurality of liposomes comprise: a first lipid or phospholipid; a second lipid or phospholipid which is derivatized with a polymer; and a sterically bulky excipient capable of stabilizing the liposomes; a third lipid or phospholipid derivatized with a polymer terminated with an integrin targeting component; DSPE or a fourth lipid or phospholipid derivatized with a group binding a contrast enhancing agent wherein the plurality of liposomes optionally encapsulates a payload component consisting of one or more bioactive agents.

Classes IPC  ?

• A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
• A61K 49/12 - Composés macromoléculaires
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• C08G 65/335 - Polymères modifiés par post-traitement chimique avec des composés organiques contenant du phosphore

Abrégé

Disclosed herein is a composition comprising a plurality of liposomes having an average diameter of less than 400 nanometers, wherein the plurality of liposomes comprise: a first lipid or phospholipid; a second lipid or phospholipid which is derivatized with a polymer; and a sterically bulky excipient capable of stabilizing the liposomes; a third lipid or phospholipid derivatized with a polymer terminated with an integrin targeting component; DSPE or a fourth lipid or phospholipid derivatized with a group binding a contrast enhancing agent wherein the plurality of liposomes optionally encapsulates a payload component consisting of one or more bioactive agents.

Classes IPC  ?

• A61K 49/00 - Préparations pour examen in vivo
• A61K 49/04 - Préparations de contraste pour rayons X
• A61K 51/00 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo

Abrégé

Readily available hydrophilic and small organofluorine moieties were condensed via "click chemistry" to generate nonionic hydrophilic fluorinated molecules with unique 19F MR signatures. These were used to fabricate stable liposome formulations for imaging various tissue types. This approach was tailored to exploit the broad spectrum of organic 19F molecular species and to generate probes with distinct 19F MRI signatures for simultaneous assessment of multiple molecular targets within the same target volume.

Classes IPC  ?

• A61K 9/10 - DispersionsÉmulsions
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes

Abrégé

19F MRI signatures for simultaneous assessment of multiple molecular targets within the same target volume.

Classes IPC  ?

• A61K 51/00 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo
• A61M 36/14 - Pansements radioactifs
• A61K 51/04 - Composés organiques
• A61K 49/10 - Composés organiques
• A61K 49/12 - Composés macromoléculaires
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes

Abrégé

The present invention is directed towards new chemical entities based on a lipid-paramagnetic metal ion chelate. The lipid portion of the compound intercalates into the membrane of a liposome. The compounds of the invention find particular use as paramagnetic contrast media for magnetic resonance imaging. It has been surprisingly discovered that the liposomal contrast media do not substantially cross the placental barrier into the vasculature of the fetus(es) when administered to a pregnant subject. These novel compounds are useful in the diagnosis of disorders and diseases in both gravid and non- gravid subjects. The invention is also directed towards pharmaceutical compositions comprising these compounds and the uses of these compounds.

Classes IPC  ?

• A61K 49/10 - Composés organiques
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61K 49/12 - Composés macromoléculaires
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes

Abrégé

Disclosed are methods of delivering substances into cells by passing cells through porous membranes. Disclosed embodiments include methods of delivering a substance into cells by providing a cell suspension, passing the cell suspension through a porous membrane, and exposing the cells to the substance to be delivered into the cells.

Classes IPC  ?

• C12N 5/07 - Cellules animales ou tissus animaux
• C12N 15/87 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation
• G01N 1/30 - TeintureImprégnation

Produits et services

Charitable services, namely, organizing and developing global pediatric programs focused on building long-term capacity to treat and improve the prognosis for children with cancer and blood disorders in the world; Promoting public awareness of pediatric programs to treat and improve the prognosis for children with cancer and blood disorders via public health campaigns and community outreach programs; Charitable services, namely, organizing and developing programs through a network of outreach centers that aim to implement best practices throughout Africa and the world Construction of medical centers focused on patient care, education, research, and healthcare management Medical training and teaching, namely, training of local healthcare workers including pathologists, nurses, pharmacists Pediatric health care services, namely, providing state-of-the-art care for children; Medical patient care

Produits et services

Canine-assisted therapy services, namely, providing a visitation program with behaviorally-certified dogs designed to provide comfort and normalcy to patients during their stay at the hospital

Abrégé

Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid-polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 49/00 - Préparations pour examen in vivo
• A61K 49/10 - Composés organiques
• A61K 49/12 - Composés macromoléculaires

Produits et services

Administration, billing and reconciliation of accounts on behalf of others; Institutional retail pharmacy services; Medical billing; Medical billing support services Accepting and administering monetary charitable contributions; Charitable fundraising; Charitable services, namely, providing financial assistance to meet the physical, psychological, social and other special needs of children; Insurance claims processing; Insurance information and consultancy Arranging transport for travelers; Transportation information Medical training and teaching; Consultancy in the field of learning difficulties Medical laboratories; Medical research Booking of temporary accommodation; Providing information in the field of temporary lodging and accommodations; Restaurant information services Emergency medical services; Health care; Health counseling; Hospital services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Nutrition counseling; Pediatric health care services; Physical therapy; Physician services; Psychological assessment services; Psychological consultation; Psychological counseling; Psychological testing Providing personal support services for patients and families of patients, namely, emotional counseling and emotional support; Spiritual counseling

Abrégé

Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid- polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

Classes IPC  ?

• A61K 49/04 - Préparations de contraste pour rayons X
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes

Abrégé

Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid-polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
• A61K 49/00 - Préparations pour examen in vivo
• A61K 49/10 - Composés organiques
• A61K 49/12 - Composés macromoléculaires

Produits et services

[ Printed training materials in the field of healthcare ] Educational services, namely, conducting classes, seminars, conferences, workshops, retreats, camps and field trips in the field of healthcare and distribution of training material in connection therewith

Abrégé

Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions comprising, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease. One such method for imaging amyloid deposits in a patient is provided, the method comprising: introducing into the patient a detectable quantity of a liposomal composition comprising a lipid-hydrophilic polymer-Formula I ligand conjugate.

Classes IPC  ?

• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes

Produits et services

Medical services, namely, prenatal evaluation, diagnosis, fetal therapy, and fetal surgery

Produits et services

Counseling in the field of health care services, medical services, nutritional counseling, physical therapy services, physician services

Produits et services

Multidisciplinary research of neurological disorders, namely, pediatric studies of the brain structure, development patterns and related neurological diseases

Produits et services

Educational services, namely, conducting classes in the field of pediatrics and distributing course material in connection therewith; educational demonstrations in the field of pediatrics; teaching in the field of pediatrics Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospitals; medical laboratory services; medical research services; medical services; nutritional counseling; physical therapy services; physician services; psychological testing; providing health care information by telephone

Produits et services

Educational services, namely, conducting classes in the field of pediatrics and distributing course materials in connection therewith; educational demonstrations in the field of pediatrics; teaching in the field of pediatrics Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospitals; medical laboratory services; medical research services; medical services; nutritional counseling; physical therapy services; physician services; psychological testing; providing health care information by telephone

Produits et services

EDUCATIONAL SERVICES, NAMELY, CONDUCTING CLASSES IN THE FIELD OF PEDIATRICS AND DISTRIBUTING COURSE MATERIALS IN CONNECTION THEREWITH; EDUCATIONAL DEMONSTRATIONS IN THE FIELD OF PEDIATRICS; TEACHING IN THE FIELD OF PEDIATRICS Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospitals; medical laboratory services; medical research services; medical services; nutritional counseling; physical therapy services; physician services; psychological testing; providing health care information by telephone

Produits et services

Dolls and doll clothing for use in educating children

Produits et services

Organizing exhibitions of artwork for health education

Produits et services

Ambulance transport services Health care services

Produits et services

Educational services, namely, conducting classes in the field of pediatrics and distributing course material in connection therewith; educational demonstrations; teaching in the field of pediatrics Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; medical laboratory services; medical research services; medical services; nutritional counseling; physical therapy services; physician services; psychological testing; providing health care information by telephone

Produits et services

Ambulance transport services Health care services

Produits et services

Educational services, namely, conducting classes in the field of pediatrics and distributing course material in connection therewith; educational demonstrations; teaching in the field of pediatrics

Produits et services

Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospital services; medical laboratory services; medical research services; medical services; nutritional counseling; pharmacy services; physical therapy services; physician services; psychological testing, providing health care information by telephone

Produits et services

Educational services, namely, conducting classes in the field of pediatrics and distributing course material in connection therewith; educational demonstrations; teaching in the field of pediatrics

Produits et services

Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospital services; medical laboratory services; medical research services; medical services; nutritional counseling; pharmacy services; physical therapy services; physician services; psychological testing; providing health care information by telephone

Produits et services

Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospital services; medical laboratory services; medical research services; medical services; nutritional counseling; pharmacy services; physical therapy services; physician services; psychological testing; providing health care information by telephone

Produits et services

Educational services, namely, conducting classes in the field of pediatrics and distributing course material in connection therewith; educational demonstrations; teaching in the field of pediatrics