Abstract

Targeted contrast agents are provided for MRI of amyloid deposition.

IPC Classes  ?

• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 49/10 - Organic compounds

Goods & Services

Medical laboratory services; medical and scientific research; providing medical testing services; providing information about medical research; research for development of pharmaceuticals and treatments; providing information for use in medical research Medical assistance; medical consultations; medical counseling; medical information; medical screening; medical services; human tissue bank services; biomedical services, namely, the storage of human cells, human tissue, human blood and human saliva for medical use; storage of biological samples

Goods & Services

Online medical consultations rendered in virtual environments; telemedicine services; pediatric health care services; nursing services

Abstract

Embodiments of the present disclosure pertain to a composition with molecules that self-assemble to form a particle. Additional embodiments of the present disclosure pertain to methods of imaging a region of a subject by: (1) administering the compositions of the present disclosure to the subject to result in the accumulation of the molecules in the region of the subject; and (2) imaging the region of the subject. In some embodiments, the imaged region includes a tumor. In some embodiments, the imaged region includes a blood vessel.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo

Goods & Services

Charitable services, namely, business administration and management of global healthcare programs; advertising services to promote public awareness of global healthcare programs via public health campaigns and community outreach programs; charitable services, namely, business administration and management of programs through a network of outreach centers that aim to implement best practices, support government health initiatives, and maximize public health impacts throughout the world; charitable services, namely, providing business administration and management of healthcare facilities and personnel. Construction of medical centers focused on patient care, education, research, and healthcare management. Medical training and teaching, namely, training of local healthcare workers including pathologists, nurses, pharmacists. Medical research; medical research in the field of epidemiology; vaccine research and development. Pediatric health care services; medical patient care; medical clinic services.

Abstract

A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: wherein X is —CH2—, —CH2—CH2—, —CHO—, or —O—CO—; Y is —CH—CH═CH— or A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: wherein X is —CH2—, —CH2—CH2—, —CHO—, or —O—CO—; Y is —CH—CH═CH— or A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: wherein X is —CH2—, —CH2—CH2—, —CHO—, or —O—CO—; Y is —CH—CH═CH— or A and B are independently selected from C and N; R1, R2, R3, and R4 are independently selected from —H, halogen, —OH, and —CH3; and R5, R6, and R7 are independently selected from —H, halogen, —OH, —OCH3, —NO2, —N(CH3)2, C1-C6 alkyl, or a substituted or unsubstituted C4-C6 aryl group, except that when A and/or B is N the adjacent R5 and/or R7 is —H, or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

• A61K 49/08 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by the carrier
• C07C 49/755 - Unsaturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
• C07C 65/40 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
• C07D 333/22 - Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 49/10 - Organic compounds

Goods & Services

Pediatric healthcare services; Emergency medical services; Health care; Health counseling; Hospital services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Nutrition counseling; Pediatric health care services; Physical therapy; Physician services; Psychological assessment services; Psychological consultation; Psychological counseling; Psychological testing

Goods & Services

Emergency medical services; Health care; Health counseling; Hospital services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Nutrition counseling; Pediatric health care services; Physical therapy; Physician services; Psychological assessment services; Psychological consultation; Psychological counseling; Psychological testing; obstetric and gynecology services; human fertility treatment services; genetic counseling

Goods & Services

Administration of health maintenance organization healthcare plans; organizing health maintenance organization healthcare plans; providing information about healthcare insurance plans; underwriting and administration of health insurance plans Arranging for and providing managed healthcare services, namely, health care in the nature of health maintenance organizations

Abstract

Methods and compositions for detecting tau pathology are described. The compositions for detecting tau pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound

Abstract

Methods and compositions for detecting tau pathology are described. The compositions for detecting tau pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Abstract

Improved nasopharyngeal swabs for COVID-19 or other molecular diagnostic testing are discussed herein. Swab designs for adult use are not suitable for pediatric use. Swabs for pediatric use need to be smaller and more flexible to navigate delicate pediatric nasopharyngeal cavities. A novel use of maxillofacial CT scans to aid in the design of pediatric nasopharyngeal swabs satisfying such criteria is discussed. Further, the novel swabs are also suitable for 3D printing.

IPC Classes  ?

• A61B 10/02 - Instruments for taking cell samples or for biopsy

Goods & Services

Educational services for pediatric patients, namely, providing a mock simulator program and educational materials in connection therewith in preparation for imaging and radiology procedures

Goods & Services

Accepting and administering monetary charitable contributions to fund medical research; Charitable fundraising; providing fundraising activities to support medical research and procedures Medical training and teaching; providing classes, workshops, seminars, conferences, and training in the field of medical research and treatment Multidisciplinary research of neurological disorders, namely, pediatric studies of the brain structure, development patterns and related neurological diseases; medical and scientific research services in the field of neurological disorders Health care; Medical services; Pediatric health care services; medical evaluation and treatment of neurological diseases and disorders; providing medical care in the field of neurological diseases and disorders

Goods & Services

Accepting and administering monetary charitable contributions to fund medical research; Charitable fundraising; providing fundraising activities to support medical research and procedures

Goods & Services

T-shirts; headwear; sweatshirts; polo shirts; jackets. Charitable fundraising services. Medical training and teaching; educational services, namely, conducting seminars, lectures, meetings, symposiums in the fields of medicine and research and distributing course materials in connection therewith; training of clinicians and scientists in the field of pediatric research; development and dissemination of educational materials in the field of medicine. Medical laboratories; medical and scientific research; providing medical testing services; providing information about medical research. Pediatric health care services; medical assistance; medical consultations; medical counseling; medical information; medical screening; medical services; nursing, medical; emergency medical services; health care; health counseling; hospital services; nutrition counseling; physical therapy; physician services; behavioral health services; providing health information; providing health information via electronic communication networks; providing information on health, wellness and nutrition via a website; providing information for patients in the field of health via a website.

Goods & Services

Providing information in the field of childhood literacy; educational services, namely, conducting programs, in the field of childhood literacy, reading schedules, and children books Providing medical information in the field of infant cognitive development; providing medical information in the field of speech and language pathology

Abstract

Embodiments of the present disclosure pertain to methods of assessing the severity of an inflammatory condition in a subject by receiving certain biomarker levels in the subject and assessing the severity of the inflammatory condition based on the measured biomarker levels. Differentially expressed levels of certain biomarkers may be correlated to a likelihood of developing a severe inflammatory condition while differentially expressed levels of other biomarkers may be correlated to a likelihood of developing a non-severe inflammatory condition. The methods of the present disclosure may also include a step of making a treatment decision based on the assessment of the severity of the inflammatory condition, such as monitoring the course of the inflammatory condition and/or administering a therapeutic agent to the subject. The method may be repeated after implementing a treatment decision in order to further assess the severity of the inflammatory condition after the treatment decision.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Goods & Services

Medical and scientific research information in the field of congenital heart disease; conducting medical research in the field of congenital heart disease and medical devices Medical clinic services; Healthcare services, namely, wellness and therapeutic programs in the field of congenital heart disease; surgery in the field of congenital heart disease

Goods & Services

Administration, billing and reconciliation of accounts on behalf of others; Medical billing; Medical billing support services Accepting and administering monetary charitable contributions; Charitable fundraising; Charitable services, namely, providing financial assistance to meet the physical, psychological, social and other special needs of children; Insurance claims processing; Insurance information and consultancy Medical training and teaching; Consultancy in the field of learning difficulties; Educational services, namely, conducting seminars, lectures, meetings, symposiums in the fields of medicine and research and distributing course materials in connection therewith; training of clinicians and scientists in the field of pediatric research; development and dissemination of educational materials in the field of medicine Medical laboratories; Medical research Charitable services, namely, providing vision screenings; Emergency medical services; Health care; Health counseling; Hospital services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Nutrition counseling; Optometry services; Pediatric health care services; Physical therapy; Physician services; Psychological assessment services; Psychological consultation; Psychological counseling; Psychological testing; Providing hearing screening services; providing health information; providing health information via electronic communication networks; providing a website featuring information on health, wellness and nutrition; providing a website featuring information for patients in the field of health Providing personal support services for patients and families of patients, namely, emotional counseling and emotional support; Spiritual counseling

Goods & Services

Administration, billing and reconciliation of accounts on behalf of others; Medical billing; Medical billing support services Insurance claims processing; Insurance information and consultancy Medical laboratories Urgent medical care centers; Health care; Health counseling; Hospital services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Nutrition counseling; Pediatric health care services; Physician services; Psychological assessment services; Psychological consultation; Psychological testing; providing health information; providing health information via electronic communication networks; providing a website featuring information on health, wellness and nutrition; providing a website featuring information for patients in the field of health

Goods & Services

Vaccine preparations. T-shirts, shirts, hats, caps. Vaccine research and development; providing information about medical and scientific research in the field of vaccine development and the prevention and treatment of COVID-19.

Abstract

Methods and compositions for detecting tau pathology are described. The compositions for detecting tau pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

Abstract

A liposomal composition (“ADx-003”) is provided, ADx-003 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand, the targeting ligand being represented by Formula I: 2—, —CHO—, or —O—CO—; Y is —CH—CH═CH— or 7 is —H, or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 49/08 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by the carrier
• C07C 49/755 - Unsaturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
• C07C 65/40 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
• C07D 333/22 - Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 49/10 - Organic compounds

Goods & Services

Charitable fundraising services Medical training and teaching; Educational services, namely, conducting seminars, lectures, meetings, symposiums in the fields of medicine and research and distributing course materials in connection therewith; training of clinicians and scientists in the field of pediatric research; development and dissemination of educational materials in the field of medicine Medical laboratories; Medical and scientific research; providing medical testing services; providing information about medical research Pediatric health care services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Emergency medical services; Health care; Health counseling; Hospital services; Nutrition counseling; Physical therapy; Physician services; behavioral health services; providing health information; providing health information via electronic communication networks; providing a website featuring information on health, wellness and nutrition; providing a website featuring information for patients in the field of health

Abstract

A liposomal composition (“ADx-001”) is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid.

IPC Classes  ?

• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 49/10 - Organic compounds
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

Goods & Services

Vaccine research and development; providing information about medical and scientific research in the field of vaccine development

Goods & Services

Providing information about the prevention and treatment of COVID-19

Goods & Services

Educational services, namely, conducting classes in the field of pediatrics and distributing course materials in connection therewith; educational demonstrations in the field of pediatrics; teaching in the field of pediatrics Medical research services; medical laboratory services Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospitals; medical services; nutritional counseling; physical therapy services; physician services; psychological testing; providing health care information by telephone

Abstract

2221234356732321646577 is -H, or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

• A61K 49/06 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes

Abstract

A liposomal composition (“ADx-001”) is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid.

IPC Classes  ?

• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 49/10 - Organic compounds

Abstract

A liposomal composition ("ADx-001") is provided, ADx-001 comprising a first phospholipid; a sterically bulky excipient that is capable of stabilizing the liposomal composition; a second phospholipid that is derivatized with a first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid that is derivatized with a second polymer, the second polymer being conjugated to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be conjugated to a fourth phospholipid.

IPC Classes  ?

• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 49/06 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations
• A61K 49/16 - AntibodiesImmunoglobulinsFragments thereof

Abstract

Disclosed herein is a composition comprising a plurality of liposomes having an average diameter of less than 400 nanometers, wherein the plurality of liposomes comprise: a first lipid or phospholipid; a second lipid or phospholipid which is derivatized with a polymer; and a sterically bulky excipient capable of stabilizing the liposomes; a third lipid or phospholipid derivatized with a polymer terminated with an integrin targeting component; DSPE or a fourth lipid or phospholipid derivatized with a group binding a contrast enhancing agent wherein the plurality of liposomes optionally encapsulates a payload component consisting of one or more bioactive agents.

IPC Classes  ?

• C07D 213/69 - Two or more oxygen atoms
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/10 - Organic compounds
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes

Abstract

Methods and compositions for detecting tau pathology are described. The compositions for detecting tan pathology comprise a targeting ligand that specifically binds to a cell surface marker of tau pathology, wherein the targeting ligand is linked to a liposome that includes an imaging agent. The compositions can be used in a method for imaging tau pathology in a subject that comprises administering to the subject an effective amount of the composition to a subject and imaging at least a portion of the subject to determine if that portion of the subject exhibits tau pathology. The compositions can also be used to detect tau pathology in biological samples obtained from a subject.

IPC Classes  ?

• C12Q 1/6811 - Selection methods for production or design of target specific oligonucleotides or binding molecules
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Goods & Services

Medical trainer kit comprised of an artificial skin and tissue model for medical instruction purposes

Abstract

Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid-polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/10 - Organic compounds
• A61K 49/12 - Macromolecular compounds

Abstract

Skeletal age determination using neural networks can use images of only a portion of a patient's hand. For example, rather than train a neural network using entire hand radiographs, the neural network may be trained with radiographs of only digits of the hand, a few digits of the hand, or a single digit of the hand. The neural network can then be used to process radiographs of a patients' digit or digits to obtain a skeletal maturity for the patient. Processing radiographs of individual digits rather than entire hands allows lower-quality (e.g., higher noise) radiographs, such as low-dose radiographs, to be used to accurately determine skeletal maturity.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/107 - Measuring physical dimensions, e.g. size of the entire body or parts thereof
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment

Goods & Services

Charitable fundraising services by means of organizing and conducting fundraising events; Charitable fundraising services for pediatric medical research and treatment programs; charitable fundraising services by means of entertainment events

Abstract

Certain embodiments of the invention are directed to methods of adjusting the concentration of one or more electrolytes in a patient's blood using a counter current electrolyte solution.

IPC Classes  ?

• A61M 1/14 - Dialysis systemsArtificial kidneysBlood oxygenators
• A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
• A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation

Abstract

The present invention is directed towards new chemical entities based on a lipid-paramagnetic metal ion chelate. The lipid portion of the compound intercalates into the membrane of a liposome. The compounds of the invention find particular use as paramagnetic contrast media for magnetic resonance imaging. It has been surprisingly discovered that the liposomal contrast media do not substantially cross the placental barrier into the vasculature of the fetus(es) when administered to a pregnant subject. These novel compounds are useful in the diagnosis of disorders and diseases in both gravid and non-gravid subjects. The invention is also directed towards pharmaceutical compositions comprising these compounds and the uses of these compounds.

IPC Classes  ?

• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 49/10 - Organic compounds
• C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table

Goods & Services

Medical training and teaching, namely, training of local healthcare workers including pathologists, nurses, pharmacists; delivery of state-of-the-art care for children; train local healthcare workers including pathologists, nurses, pharmacists; conduct public health campaigns and community outreach programs to increase awareness; establish centers focused on patient care, education, research, and healthcare management; develop a network of centers to implement best practices throughout Africa and the world.

Goods & Services

Charitable fundraising; On-line charitable fundraising

Abstract

Disclosed herein is a composition comprising a plurality of liposomes having an average diameter of less than 400 nanometers, wherein the plurality of liposomes comprise: a first lipid or phospholipid; a second lipid or phospholipid which is derivatized with a polymer; and a sterically bulky excipient capable of stabilizing the liposomes; a third lipid or phospholipid derivatized with a polymer terminated with an integrin targeting component; DSPE or a fourth lipid or phospholipid derivatized with a group binding a contrast enhancing agent wherein the plurality of liposomes optionally encapsulates a payload component consisting of one or more bioactive agents.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61K 49/04 - X-ray contrast preparations
• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo

Abstract

Readily available hydrophilic and small organofluorine moieties were condensed via "click chemistry" to generate nonionic hydrophilic fluorinated molecules with unique 19F MR signatures. These were used to fabricate stable liposome formulations for imaging various tissue types. This approach was tailored to exploit the broad spectrum of organic 19F molecular species and to generate probes with distinct 19F MRI signatures for simultaneous assessment of multiple molecular targets within the same target volume.

IPC Classes  ?

• A61K 9/10 - DispersionsEmulsions
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes

Abstract

19F MRI signatures for simultaneous assessment of multiple molecular targets within the same target volume.

IPC Classes  ?

• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo
• A61M 36/14 - Radioactive dressings
• A61K 51/04 - Organic compounds
• A61K 49/10 - Organic compounds
• A61K 49/12 - Macromolecular compounds
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

Abstract

The present invention is directed towards new chemical entities based on a lipid-paramagnetic metal ion chelate. The lipid portion of the compound intercalates into the membrane of a liposome. The compounds of the invention find particular use as paramagnetic contrast media for magnetic resonance imaging. It has been surprisingly discovered that the liposomal contrast media do not substantially cross the placental barrier into the vasculature of the fetus(es) when administered to a pregnant subject. These novel compounds are useful in the diagnosis of disorders and diseases in both gravid and non- gravid subjects. The invention is also directed towards pharmaceutical compositions comprising these compounds and the uses of these compounds.

IPC Classes  ?

• A61K 49/10 - Organic compounds
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61K 49/12 - Macromolecular compounds
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes

Abstract

Disclosed are methods of delivering substances into cells by passing cells through porous membranes. Disclosed embodiments include methods of delivering a substance into cells by providing a cell suspension, passing the cell suspension through a porous membrane, and exposing the cells to the substance to be delivered into the cells.

IPC Classes  ?

• C12N 5/07 - Animal cells or tissues
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
• G01N 1/30 - StainingImpregnating

Goods & Services

Charitable services, namely, organizing and developing global pediatric programs focused on building long-term capacity to treat and improve the prognosis for children with cancer and blood disorders in the world; Promoting public awareness of pediatric programs to treat and improve the prognosis for children with cancer and blood disorders via public health campaigns and community outreach programs; Charitable services, namely, organizing and developing programs through a network of outreach centers that aim to implement best practices throughout Africa and the world Construction of medical centers focused on patient care, education, research, and healthcare management Medical training and teaching, namely, training of local healthcare workers including pathologists, nurses, pharmacists Pediatric health care services, namely, providing state-of-the-art care for children; Medical patient care

Goods & Services

Canine-assisted therapy services, namely, providing a visitation program with behaviorally-certified dogs designed to provide comfort and normalcy to patients during their stay at the hospital

Abstract

Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid-polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/10 - Organic compounds
• A61K 49/12 - Macromolecular compounds

Goods & Services

Administration, billing and reconciliation of accounts on behalf of others; Institutional retail pharmacy services; Medical billing; Medical billing support services Accepting and administering monetary charitable contributions; Charitable fundraising; Charitable services, namely, providing financial assistance to meet the physical, psychological, social and other special needs of children; Insurance claims processing; Insurance information and consultancy Arranging transport for travelers; Transportation information Medical training and teaching; Consultancy in the field of learning difficulties Medical laboratories; Medical research Booking of temporary accommodation; Providing information in the field of temporary lodging and accommodations; Restaurant information services Emergency medical services; Health care; Health counseling; Hospital services; Medical assistance; Medical consultations; Medical counseling; Medical information; Medical screening; Medical services; Nursing, medical; Nutrition counseling; Pediatric health care services; Physical therapy; Physician services; Psychological assessment services; Psychological consultation; Psychological counseling; Psychological testing Providing personal support services for patients and families of patients, namely, emotional counseling and emotional support; Spiritual counseling

Abstract

Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid- polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

IPC Classes  ?

• A61K 49/04 - X-ray contrast preparations
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes

Abstract

Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid-polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/10 - Organic compounds
• A61K 49/12 - Macromolecular compounds

Goods & Services

[ Printed training materials in the field of healthcare ] Educational services, namely, conducting classes, seminars, conferences, workshops, retreats, camps and field trips in the field of healthcare and distribution of training material in connection therewith

Abstract

Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions comprising, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease. One such method for imaging amyloid deposits in a patient is provided, the method comprising: introducing into the patient a detectable quantity of a liposomal composition comprising a lipid-hydrophilic polymer-Formula I ligand conjugate.

IPC Classes  ?

• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes

Goods & Services

Medical services, namely, prenatal evaluation, diagnosis, fetal therapy, and fetal surgery

Goods & Services

Counseling in the field of health care services, medical services, nutritional counseling, physical therapy services, physician services

Goods & Services

Multidisciplinary research of neurological disorders, namely, pediatric studies of the brain structure, development patterns and related neurological diseases

Goods & Services

Educational services, namely, conducting classes in the field of pediatrics and distributing course material in connection therewith; educational demonstrations in the field of pediatrics; teaching in the field of pediatrics Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospitals; medical laboratory services; medical research services; medical services; nutritional counseling; physical therapy services; physician services; psychological testing; providing health care information by telephone

Goods & Services

Educational services, namely, conducting classes in the field of pediatrics and distributing course materials in connection therewith; educational demonstrations in the field of pediatrics; teaching in the field of pediatrics Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospitals; medical laboratory services; medical research services; medical services; nutritional counseling; physical therapy services; physician services; psychological testing; providing health care information by telephone

Goods & Services

EDUCATIONAL SERVICES, NAMELY, CONDUCTING CLASSES IN THE FIELD OF PEDIATRICS AND DISTRIBUTING COURSE MATERIALS IN CONNECTION THEREWITH; EDUCATIONAL DEMONSTRATIONS IN THE FIELD OF PEDIATRICS; TEACHING IN THE FIELD OF PEDIATRICS Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospitals; medical laboratory services; medical research services; medical services; nutritional counseling; physical therapy services; physician services; psychological testing; providing health care information by telephone

Goods & Services

Dolls and doll clothing for use in educating children

Goods & Services

Organizing exhibitions of artwork for health education

Goods & Services

Ambulance transport services Health care services

Goods & Services

Educational services, namely, conducting classes in the field of pediatrics and distributing course material in connection therewith; educational demonstrations; teaching in the field of pediatrics Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; medical laboratory services; medical research services; medical services; nutritional counseling; physical therapy services; physician services; psychological testing; providing health care information by telephone

Goods & Services

Ambulance transport services Health care services

Goods & Services

Educational services, namely, conducting classes in the field of pediatrics and distributing course material in connection therewith; educational demonstrations; teaching in the field of pediatrics

Goods & Services

Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospital services; medical laboratory services; medical research services; medical services; nutritional counseling; pharmacy services; physical therapy services; physician services; psychological testing, providing health care information by telephone

Goods & Services

Educational services, namely, conducting classes in the field of pediatrics and distributing course material in connection therewith; educational demonstrations; teaching in the field of pediatrics

Goods & Services

Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospital services; medical laboratory services; medical research services; medical services; nutritional counseling; pharmacy services; physical therapy services; physician services; psychological testing; providing health care information by telephone

Goods & Services

Counseling in the field of learning development; emergency medical assistance; food nutrition consultation; health care services; hospital services; medical laboratory services; medical research services; medical services; nutritional counseling; pharmacy services; physical therapy services; physician services; psychological testing; providing health care information by telephone

Goods & Services

Educational services, namely, conducting classes in the field of pediatrics and distributing course material in connection therewith; educational demonstrations; teaching in the field of pediatrics

Abstract

Disclosed herein is a composition comprising a plurality of liposomes having
an average
diameter of less than 400 nanometers, wherein the plurality of liposomes
comprise: a first lipid or
phospholipid; a second lipid or phospholipid which is derivatized with a
polymer; and a sterically
bulky excipient capable of stabilizing the liposomes; a third lipid or
phospholipid derivatized with
a polymer terminated with an integrin targeting component; DSPE or a fourth
lipid or phospholipid
derivatized with a group binding a contrast enhancing agent wherein the
plurality of liposomes
optionally encapsulates a payload component consisting of one or more
bioactive agents.

IPC Classes  ?

• A61K 49/12 - Macromolecular compounds
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• C08G 65/335 - Polymers modified by chemical after-treatment with organic compounds containing phosphorus