The invention relates to a Method of operating a process arrangement (1), in particular bioprocess arrangement, wherein the method comprises a separation of two phases of an aqueous-two-phase system (2). It is proposed that the process arrangement (1) comprises a fluidized bed centrifuge (3), that the fluidized bed centrifuge (3) is used for the separation of the two phases of the aqueous-two-phase system (2), that the aqueous-two-phase system (2) is loaded into a rotating chamber (4) of the fluidized bed centrifuge (3) as a fluid flow, that due to the rotation of the chamber (4) the aqueous-two-phase system (2) is centrifuged such that a first phase (7) of the two phases is separated 10 from a second phase (8) of the two phases, and, that due to the fluid flow during the rotation of the chamber (4), the first phase (7) remains in the chamber (4) while the second phase (8) leaves the chamber (4), such that the two phases are separated.
The invention relates to a filtration unit, in particular a syringe attachment filter or syringe filter holder, for filtering of a fluid, the filtration unit comprising: a first housing part comprising at least one first fluid chamber for a fluid to be filtered; a second housing part comprising at least one second fluid chamber for a filtered fluid; a filter element configured to fluidly connect the first chamber and the second chamber and to filter the fluid to be filtered; wherein the second housing part comprises: a support surface for supporting a fringe area of the filter element; and a rib element protruding from the support surface, at least a distal portion of the rib element consisting of or comprising a material substantially fusible by welding; wherein the first housing part comprises: an abutting surface for substantially abutting with the distal portion of the rib element, the abutting surface at least partly facing the support surface of the second housing part; and a barrier element protruding from the abutting surface towards the support surface and positioned relative to the rib element so as to laterally enclose an inner melt cavity therebetween, wherein the inner melt cavity upon welding is at least partially filled with solidified melt originating from fused material of the distal portion of the rib element, wherein the first housing part and the filter element and, optionally, the second housing part are to be coupled to one another via the solidified melt in the inner melt cavity.
B01D 29/01 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants avec des éléments filtrants plats
B01D 29/11 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants avec des éléments filtrants en forme de sac, de cage, de tuyau, de tube, de manchon ou analogue
The present invention relates to a porous polymer membrane having the combination of a specific average pore diameter, a specific thickness, and a specific convective porosity. Moreover, the present invention relates to a method of manufacturing such porous polymer membrane.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Machines and machine tools for use in biopharmaceutical and laboratory manufacturing; Valves [parts of machines]; Machine couplings and connectors, except for land vehicles; Disposable machine elements for creating and separating sterile connections between apparatus of plastic, including tubes, pipes, bags, containers and filters. Laboratory apparatus and instruments; Connectors for laboratory apparatus; Couplings for laboratory apparatus; Valves for laboratory apparatus; Aseptic connectors for laboratory use; Apparatus and instruments for the sterile connection and separation of plastic vessels, including plastic tubes, pipes, bags, containers and filters; Devices for sterile fluid transfer for laboratory apparatus. Apparatus for sterilizing; Filters for fluids [parts of household or industrial installations]; Valves; Couplings; Disposable elements for sterile connection and separation in fluid treatment systems.
5.
METHOD OF REFERENCING AN ANALYTE MEASUREMENT IN A PURIFICATION SYSTEM
In a method of referencing an analyte measurement in a purification system during a process step in a biopharmaceutical process, the following sub-steps are performed during the same process step: guiding a medium through a purification unit where the analyte is either removed from or added to the medium; measuring at least one parameter related to the presence and/or quantity of the analyte with a first measurement system at a first measurement location upstream of the purification unit; measuring the at least one parameter with a second measurement system at a second measurement location downstream of the purification unit; and referencing the upstream measurement to the downstream measurement, or referencing the downstream measurement to the upstream measurement.
The present invention relates to a method for releasing a viral vector from a cell culture, wherein a cell of the cell culture is not required to be separated from the surrounding liquid prior to contacting the cell culture with the lysis reagent. The present invention further relates to a method for producing a viral vector inter alia comprising releasing the viral vector from a cell culture according to disclosed method for releasing a viral vector from a cell culture. The present invention further relates to a cell lysis reagent for releasing a viral vector from a cell culture. The present invention further relates to a kit for releasing a viral vector from a cell culture, wherein the kit comprises a container that contains the disclosed cell lysis reagent.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
The present invention provides methods for releasing a viral vector from a cell culture. Specifically, the cell culture is contacted with a lysis reagent to generate a lysis composition and incubated, whereupon the lysis composition is contacted with an acidifying reagent to lower the pH. The method according to the present invention results in high viral vector release and reduction in co-released host cell related impurities. The present invention further provides a method for producing a viral vector. The present invention further provides a kit for releasing a viral vector from a cell culture. The present invention further provides a kit for producing a viral vector.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
The invention relates to a method for controlling a bioprocess (1), wherein in a model control routine (5) a bioprocess control unit (4) controls at least one process parameter (6) of the bioprocess (1) according to a model-based control loop (7). It is proposed that during the model control routine (5) the bioprocess control unit (4) repeatedly performs a first evaluation (13) of the model-based control loop (7), that if a first decision criterion is fulfilled, the bioprocess control unit (4) switches from the model control routine (5) to a sample control routine (15), that in the sample control routine (15) the bioprocess control unit (4) controls the bioprocess (1) according to a sample-based control loop (23), that at least one sample input parameter (24) of the sample-based control loop (23) is derived from a measurement value.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
G05B 13/04 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques impliquant l'usage de modèles ou de simulateurs
G05B 17/02 - Systèmes impliquant l'usage de modèles ou de simulateurs desdits systèmes électriques
9.
METHOD OF CONTROLLING A BIOPROCESS ARRANGEMENT TO PROVIDE MEASUREMENT DATA TO A BIOPROCESS CONTROL SYSTEM
The invention relates to a method of controlling a bioprocess arrangement (1) to provide measurement data to a bioprocess control system (3), wherein the bioprocess arrangement (1) comprises a biocontainer arrangement (2), a sampling arrangement (4), a routing arrangement (6) and an analysis arrangement (7). It is proposed that the bioprocess control system (3) sends a measurement request to the control layer (9), that the measurement request contains information about a requested measurement, that the measurement request is independent of routing and analysis behind the sampling arrangement (4), that the sampling arrangement (4) draws the sample and provides the sample to the routing arrangement (6), that the control layer (9) coordinates the provision of the sample to the analysis arrangement (7) via the routing arrangement (6), that the analysis arrangement (7) sends measurement data to the control layer (9), and, that the control layer (9) sends the measurement data to the bioprocess control system (3).
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
G01N 1/02 - Dispositifs pour prélever des échantillons
10.
DEVICE FOR ARRANGING ON A FLUID-CONDUCTING LINE AND FOR ATTACHING A FLOWMETER, AND METHOD FOR DETECTING A MEASUREMENT VARIABLE OF THE FLUID BEING CONDUCTED BY A LINE
A device for arranging on a fluid-conducting line and for attaching a flowmeter, in particular an ultrasonic flowmeter, for detecting a measurement variable of the fluid conducted by the line has a first and a second connection, and a measurement region arranged between the first connection and the second connection. The first connection, the measurement region, and the second connection define a flow path for the fluid through the device, and a flow-influencing element arranged in and/or on the flow path is configured to cause fluid flowing into the device via the first connection with a substantially laminar flow to have a substantially turbulent flow in the measurement region.
G01F 1/66 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en mesurant la fréquence, le déphasage, le temps de propagation d'ondes électromagnétiques ou d'autres types d'ondes, p. ex. en utilisant des débitmètres à ultrasons
G01F 15/18 - Supports ou moyens de raccordement pour les compteurs
11.
APPLICATION OF PERMITTIVITY MEASUREMENT PROBES IN AN SUSPENSION CULTURE AGGREGATE COMPRISING CELL AGGREGATES
The present disclosure relates to a method of measuring cell density in a cell suspension comprising cell aggregates, the method comprising (i) Measuring the permittivity of the cell suspension; (ii) Comparing the measured permittivity with a predetermined value that is indicative of the cell density, thereby determining the cell density. Further described is a of a permittivity probe for determining the cell density of a suspension cell culture comprising cell aggregates.
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
12.
TEST PLAQUE FOR VALIDATION OF INJECTION MOULDING MATERIAL RHEOLOGICAL CHARACTERISATION
The invention relates to a test specimen (1) for rheological testing of plastic products comprising a plate body (10) from a plastic material, said plate body (10) having a first major surface (102), a second major surface opposite to the first major surface (102) and a side surface (106) connecting the first and the second major surface (104) and at least one spatial feature (12A, 12B, 14A, 14B) arranged in or on the plate body (10), each spatial feature (12A, 12B, 14A, 14B) indicative of a defect occurring in the plastic products or a geometric feature of the plastic products. The invention relates further to methods and respective systems using the test specimen, including methods and systems for testing for testing of a plastic product, for validating a rheological data set or a model of a process for manufacturing of plastic products, for determining at least one property of a plastic product to be manufactured and for manufacturing a plastic product.
G01N 11/00 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement
13.
METHODS FOR PROCESSING AND/OR PURIFICATION OF A BIOLOGICAL PRODUCT INVOLVING MULTI-ANGLE LIGHT SCATTERING AS ANALYTICAL TOOL FOR PROCESS CONTROL
The present invention concerns methods for processing and/or purification of a biological product involving multi-angle light scattering as analytical tool for process control. The methods of the invention apply multi-angle light scattering to detect the biological product, the presence of a bioburden or the functionality and/or integrity of a consumable employed in the method for processing and/or purification of the biological product. Further, the invention relates to systems for processing and/or purification of a biological product configured to perform the methods of the invention. Lastly, the invention concerns computer program products which can be used in the methods of the invention.
B01D 15/08 - Adsorption sélective, p. ex. chromatographie
G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
14.
SYSTEM FOR DETECTING A MEASUREMENT VARIABLE OF A FLUID CONDUCTED IN A FLUID-CONDUCTING LINE, FLOW-THROUGH DEVICE FOR ARRANGING ON A FLUID-CONDUCTING LINE AND FOR ATTACHING A FLOWMETER, AND USE OF A FLOW-THROUGH DEVICE
A system for detecting a measurement variable of a fluid being conducted in a fluid-conducting line, having a flowmeter for detecting the measurement variable, a flow-through device for arranging on the fluid-conducting line and for attaching the flowmeter. The flowmeter has a first and second connection and a measurement region which is arranged between the first connection and the second connection and which can be coupled to the flowmeter. The first connection, the measurement region, and the second connection define a flow path for the fluid through the flow-through device.
G01F 1/66 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en mesurant la fréquence, le déphasage, le temps de propagation d'ondes électromagnétiques ou d'autres types d'ondes, p. ex. en utilisant des débitmètres à ultrasons
G01F 15/18 - Supports ou moyens de raccordement pour les compteurs
15.
BIOREACTOR FOR CELL CULTURE WITH REUSABLE REACTOR VESSEL AND OPTICAL SPECTROSCOPY INTERFACE
A bioreactor for cell cultivation including a reusable reactor vessel, preferably made of stainless steel, for receiving a fluid, and an optical spectroscopy interface including an adapter and a single-use optical spectroscopy insert. The reusable reactor vessel has a wall and a port formed in the wall. The adapter is configured to be fixed to the port in a predefined position at the port. The single-use optical spectroscopy insert is configured to be accommodated and fixed in the adapter, or the insert is an integral part of the adapter.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
16.
METHOD OF PERFORMING GAS/LIQUID-BASED INTEGRITY TEST
The present invention relates to a method of performing a gas/liquid-based integrity test, wherein air in a first membrane and a second membrane and present therebetween is replaced by a water-soluble gas before wetting the membranes. Further, the present invention relates to a method of producing an integrity-tested object having a first membrane, a second membrane and at least one boundary member.
MULTIPORT DEVICE FOR CONNECTING A LOOP TO ONE PORT OF A BIOREACTOR, AND PERFUSION OR CONCENTRATED FED-BATCH SETUP FOR PERFORMING AN UPSTREAM PROCESS OF CELL CULTURE
A multiport device for connecting a loop, preferably a tangential flow filtration loop or a sensor loop, to one port of a bioreactor, preferably a single-use bioreactor, is configured to be fixed to the port of the bioreactor. The multiport device includes a first flow path configured for withdrawing fluid from the bioreactor, and a second flow path configured for supplying fluid to the bioreactor. The first flow path has a first end adapted to be in fluid connection with the bioreactor, and a second end adapted to be connected to an inlet of the loop. The second flow path has an outer end adapted to be connected to an outlet of the loop, and a mouth adapted to be in fluid connection with the bioreactor. The mouth of the second flow path is distanced from the first end of the first flow path by at least 5 mm, preferably 10 mm.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/02 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'agitationAppareillage pour l'enzymologie ou la microbiologie avec des moyens d'échange de chaleur
18.
SYSTEMS AND METHODS INVOLVING CONTROLLED OXYGEN RELEASE IN BIOMATERIALS
Some aspects of the disclosure are related to systems and methods for controlled oxygen release from biomaterials in vessels and unit operations or components of cell culture, cell containment, and/or bioreactor. Vessels, unit operations, devices, and/or components of the invention may be used to perform all or part of a biological and/or chemical process involving biologicals (e.g., a plurality of cells) in the presence of oxygen-releasing agents. In some embodiments, a system comprises a vessel comprises an oxygen-releasing agent configured to generate in-situ and release oxygen in a sustained manner. The presence of an oxygen-releasing agent may advantageously allow for high cell density fermentation and cell cultivation in a vessel and provide an alternative for supplemental gassing means (e.g., sparger, etc.). Some embodiments of the disclosure are directed to employing the oxygen-releasing agents in microfluidic or millifluidic systems.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
19.
SEPARATION SYSTEM FOR SEPARATING AND PURIFYING A TARGET COMPONENT
A separation system and methods for separating and purifying a target component include a separation system for separating and purifying a target component, a method for separating and purifying a target component, and the use of a single-pass crossflow diafiltration unit for integrally connecting a first and a second chromatography device.
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
B01D 15/14 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à l'introduction de l'alimentation dans l'appareil
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
B01D 61/16 - Prétraitement du courant d'alimentation
Containers including internal mixers and actuators assemblies and related methods are generally described. In some embodiments, a container may include a mixer and an actuator, at least one of which may be located inside of the container. The actuator may actuate the mixer to induce flow within the container and mix the contents of the container with a low volumetric footprint and high mixing efficiency. In some embodiments, the actuator may be configured to deform the mixer, which may include one or more features which may be deformed out of plane in a Kirigami or Origami fashion. The actuator and mixer may be arranged in series or in parallel. The actuator may be used without a mixer to induce flow within the container. The actuator may be driven pneumatically, hydraulically, electrically, and/or in any other suitable manner.
B01F 31/44 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants avec des agitateurs effectuant un mouvement oscillatoire, vibratoire ou de secousses
B01F 35/513 - Récipients souples, p. ex. sacs supportés par des conteneurs rigides
21.
BIOREACTOR WITH FILTER UNIT AND METHOD FOR TREATING A CELL BROTH
A bioreactor having a filter unit and a method for treating a cell broth. The filter unit has a supply channel (2), a first filter medium (4), a retentate channel (1), a second filter medium (5) and a permeate channel (3), arranged so that the first filter medium delimits the supply channel and the retentate channel from one another; and the second filter medium delimits the retentate channel and the permeate channel from one another. The supply channel is connected to an inlet for a supply medium; the retentate channel is connected to an inlet for a cell broth and to an outlet for the cell broth; the permeate channel is connected to an outlet for a permeate; and the interior of the bioreactor is connected to the inlet for the cell broth and to the outlet for the cell broth.
A tubular flow device (10) for enabling controlled flow of a fluid at a measuring point comprises an inlet flow channel (14) defining a main inflow direction, and an outlet flow channel (18) defining a main outflow direction. The flow device (10) further comprises a branching portion (22) where the inlet flow channel (14) is divided into a primary flow channel (24) and a secondary measurement channel (26), and a joining portion (36) where the primary flow channel (24) and the secondary measurement channel (26) open into the outlet flow channel (18). The measuring point is located in the secondary measurement channel (26). The primary flow channel (24) is longer than the secondary measurement channel (26) and has a constriction (42) downstream of the branching portion (22). A fluid entering the inlet flow channel (14) is divided into a primary flow flowing into the primary flow channel (24) and a secondary measurement flow flowing into the secondary measurement channel (26). The primary flow and the secondary measurement flow reach the joining portion (36) essentially at the same time, due to the Venturi effect caused by the constriction (42) of the primary flow channel (24).
B33Y 80/00 - Produits obtenus par fabrication additive
G01F 1/661 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en mesurant la fréquence, le déphasage, le temps de propagation d'ondes électromagnétiques ou d'autres types d'ondes, p. ex. en utilisant des débitmètres à ultrasons en utilisant la lumière
G01F 5/00 - Mesure d'une fraction du débit volumétrique
G01F 15/00 - Détails des appareils des groupes ou accessoires pour ces derniers, dans la mesure où de tels accessoires ou détails ne sont pas adaptés à ces types particuliers d'appareils, p. ex. pour l'indication à distance
G01F 1/50 - Moyens de correction ou de compensation
G01F 15/14 - Revêtements, p. ex. avec un matériau spécial
23.
A METHOD OF PRODUCING DIFFERENTIATED CELLS FROM PLURIPOTENT STEM CELLS, CELL POPULATIONS OBTAINED BY THE METHOD, CORRESPONDING PHARMACEUTICAL COMPOSITIONS AND A SYSTEM FOR PRODUCING DIFFERENTIATED CELLS FROM PLURIPOTENT STEM CELLS
The present invention inter alia relates to a method of producing differentiated cells from pluripotent stem cells, comprising providing at least one multicellular 3D aggregate derived from pluripotent stem cells cultured in a first suspension culture, inducing differentiation of the cells forming the at least one multicellular 3D aggregate, allowing a continuous release of differentiated cells from the multicellular 3D aggregate into the first suspension culture; and continuously separating the released differentiated cells from the first suspension culture. The present invention also relates to a cell obtained by the method and to a pharmaceutical composition comprising the cells. The invention further relates to a corresponding system for producing differentiated cells from pluripotent stem cells.
A bioprocess assembly (10) comprises a separation system (12) and a sampling system (14). The sampling system (14) is fluidically connected to the separation system (12) and comprises a sampling membrane (32) such that the separation system (12) and the sampling membrane (32) provide a separate sampling channel (30). The sampling channel (30) comprises at least one fluidic connection (36) to receive a buffer and at least one fluidic connection (51) to a sampling station (50). Further, the sampling channel (30) comprises a counter pressure generating unit (48) and at least one sensor (40), wherein the counter pressure generating unit (48) is configured to adjust the pressure within the sampling channel (30) based on data collected by the at least one sensor (40).
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
G01N 1/20 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide pour matériau coulant ou s'éboulant
25.
DEVICE ASSEMBLY AND METHOD FOR A PRODUCTION-SCALE TANGENTIAL FLOW FILTRATION
A device assembly (10) for performing a production scale tangential flow filtration of a feed, preferably in a batch feed and bleed process, comprises a first loop (12) including a first tubing (20), a feed tank (22) and actuators and sensors adapted to the first tubing (20), and a second loop (14) including second tubing (28) and a filter (28), preferably a hollow fiber filter. The first loop (12) and the second loop (14) further include a common tubing section. The first loop (12) connects to the second loop (14) at a first connection point (16) upstream, or alternatively downstream, of the filter (28), and the second loop (14) connects to the first loop (12) at a second connection point (18) downstream, or alternatively upstream, of the filter (28), such that the first loop (12) supplies the feed from the feed tank (22) to the second loop (14) at the first connection point (16), or alternatively at the second connection point (18), and the second loop (14) supplies retentate to the first loop (12) at the second connection point (18) from where a part of the retentate is returned to the feed tank (22), or alternatively at the first connection point (14). At least all wetted parts of the device assembly (10) are single-use parts and the inner diameter of the first tubing (20) is smaller than the inner diameter of the second tubing (32).
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci
Kirigami mixing systems and related methods are generally described. In some embodiments, a mixing system includes one or more grippers configured to deform a portion of a flexible container containing fluid when undergoing axial deformation. The grippers may include features including slots, hinges, and spines to aid in the transition of the grippers between a closed and retracted configuration when the one or more grippers are deformed. The compression of the container subsequently result in fluid flow within the container which may mix or agitate the fluid. In some embodiments, the described grippers may be formed integrally with the flexible containers. In some embodiments, the mixing system may include a plurality of grippers arranged around the flexible container.
B01F 31/55 - Mélangeurs avec mécanismes à secousses, oscillants ou vibrants les matières à mélanger étant contenues dans un sac souple soumis à une déformation périodique
B01F 35/513 - Récipients souples, p. ex. sacs supportés par des conteneurs rigides
27.
METHOD OF OPERATING A BIOPROCESS ARRANGEMENT TO PERFORM AT LEAST ONE REPETITION OF A BIOPROCESS
The invention relates to a method of operating a bioprocess arrangement (1) to perform at least one repetition of a bioprocess, wherein the bioprocess arrangement (1) comprises at least one replaceable electronic component (8), wherein a process control system (7) controls the bioprocess arrangement (1), using a digital model (10). It is proposed that the replaceable electronic components (8) are removed and replaced by new electronic components (9), that the process control system (7) automatically detects the removal of the replaceable electronic components (8), automatically detects the presence of the new electronic components (9) and retrieves digital representations (11) of the new electronic components (9) based on the communication with the new electronic components (9), that the process control system (7) derives from the digital representations (11) of the replaceable electronic components (8) and the new electronic components (9) a functional relationship between the replaceable electronic components (8) and the new electronic components (9), that the process control system (7) replaces the digital representations (11) of the replaceable electronic components (8) with the digital representations (11) of the new electronic components (9) based on the functional relationship thereby updating the digital model (10), and, that the process control system (7) controls the bioprocess arrangement (1) to perform the bioprocess based 20 on the updated digital model (10).
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
28.
FLOW-THROUGH CENTRIFUGE AND METHOD FOR BRINGING ABOUT AN OPERATIONAL STATE OF A FLOW-THROUGH CENTRIFUGE
The invention relates to a flow-through centrifuge which is used, for example, for biotechnical applications, in particular as a blood centrifuge. A driving arrangement and/or transmission arrangement of the flow-through centrifuge comprises a planetary gearset. In the planetary gearset, at least one planetary belt pulley is rotatably supported on a rotating planet carrier. A torque of the planetary belt pulley is transmitted via a belt. The planet carrier and the planetary belt pulley are driven at different rotational speeds. According to the invention, the planet carrier is held by a belt tensioning unit rotating with the planet carrier. A distance of the planet carrier from a rotor axis can be changed via the belt tensioning unit in order to adjust the belt tension of the belt.
A valve switching system for selectively interconnecting components of a bioprocess installation, comprising a valve switching cassette and an actuator block. It is proposed, that the valve switching cassette comprises a perforated sandwich plate with perforation holes, which sandwich plate is placed between the cassette manifold and the actuator block body.
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
F16K 11/22 - Soupapes ou clapets à voies multiples, p. ex. clapets mélangeursRaccords de tuyauteries comportant de tels clapets ou soupapesAménagement d'obturateurs et de voies d'écoulement spécialement conçu pour mélanger les fluides dont plusieurs éléments de fermeture ne se déplacent pas comme un tout actionnés par des organes de commande distincts chacun étant propre à une soupape, p. ex. conjugués pour former clapet à voies multiples
F16K 31/126 - Moyens de fonctionnementDispositifs de retour à la position de repos actionnés par un fluide le fluide agissant sur un diaphragme, un soufflet ou un organe similaire
30.
METHOD OF OPERATING A BIOPROCESS ARRANGEMENT TO PERFORM AT LEAST ONE REPETITION OF A BIOPROCESS
A method of operating a bioprocess arrangement to perform repetition of a bioprocess, wherein the bioprocess arrangement comprises a replaceable electronic component, wherein a process control system controls the bioprocess arrangement, using a digital model. The replaceable electronic components are removed and replaced by new electronic components, the process control system automatically detects the removal of the electronic components, automatically detects the presence of the new electronic components and retrieves digital representations of the new components, the process control system derives from the digital representations of the replaceable components and the new components a functional relationship, the process control system replaces the digital representations of the replaceable components with the digital representations of the new components based on the functional relationship thereby updating the digital model, and, that the process control system controls the bioprocess arrangement to perform the bioprocess based on the updated digital model.
G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
A method for validating a filter unit. The method includes guiding a fluid flow of a fluid after the fluid flow passed through the filter unit to a measurement area that is connected to the filter unit. The measurement area the fluid is exposed to is at least one alternating electric field between at least two electrodes. The method includes obtaining at least one electric signal between the at least two electrodes. The at least one electric signal is at least affected by whether one or more cells of a plurality of cells in the fluid pass through the measurement area. The method includes determining, at least partially based on the obtained at least one electric signal, at least one validity information indicating a validity of the filter unit.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
07 - Machines et machines-outils
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
37 - Services de construction; extraction minière; installation et réparation
Produits et services
Chemicals and reagents for use in media and buffer
preparation, seed train, filtration, chromatography, and
virus clearance in biotechnology and biopharmaceutical
industries; chemicals for industrial and laboratory use in
biopharmaceutical processing, including those for filtration
and purification of biological materials. Machinery and automated equipment for media and buffer
preparation, seed train, filtration, chromatography, and
polishing; industrial robots and apparatus for bioprocessing
and manufacturing including filtration systems for the
purification and separation of biological substances. Scientific, research, and laboratory apparatus for use in
biopharmaceutical manufacturing, namely, apparatus for media
and buffer preparation, seed train and production,
filtration, chromatography, polishing and virus clearance;
downloadable and recorded software for biopharmaceutical
processes, namely, software for media preparation, buffer
preparation, seed train optimization, filtration,
chromatography, polishing, and virus clearance; control
systems and software for automating biopharmaceutical
processes, namely, software for filtration and purification
processes; interfaces and human-machine interface (HMI)
software for managing and optimizing biopharmaceutical
processes; data collection and management software for
process intensification systems; devices for real-time
monitoring and optimization for biopharmaceutical
production. Industrial filtration apparatus for water, air, and gas
purification; chromatography apparatus for biopharmaceutical
purification; process systems and equipment for the
filtration, purification, and separation of biological
substances in biopharmaceutical processes, namely,
filtration systems for bioprocessing. Installation and maintenance of process intensification
systems for biopharmaceutical production.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific and technological research services in the field
of biopharmaceuticals, specifically relating to bioprocess
optimization, including media and buffer preparation, seed
train, filtration, chromatography, and virus clearance;
design and development of computer software for
biopharmaceutical process automation and control; technical
consultancy services related to biopharmaceutical process
optimization, focusing on bioprocess steps namely,
filtration, chromatography, and virus clearance; software as
a service (SaaS) for biopharmaceutical manufacturing,
including media and buffer preparation, seed train,
filtration, chromatography, polishing and virus clearance;
IT services in relation to cloud-based interfaces for
managing biopharmaceutical manufacturing processes, namely,
interfaces for filtration, purification, and virus clearance
systems; testing and validation services for bioprocessing
equipment and systems; process scale-up technical consulting
and technical support for biopharmaceutical production.
Various embodiments provide a method for producing a bioproduct using a bioprocess installation. The bioprocess installation comprises an process control and a bioprocess unit. The bioprocess unit comprises a receptacle, a clarification unit with a centrifuge and a chromatography unit with a chromatograph. Cell broth obtained from the receptacle is lead through the clarification unit and the chromatography unit in a liquid stream. The clarification unit with its centrifuge is being operated in a centrifugation cycle comprising centrifugation steps. The chromatography unit with its chromatograph is being operated in a chromatography cycle comprising chromatography steps. The particle depletion can be less than 10% in particle concentration and that the execution of the steps assigned to the centrifugation cycle and the execution of the steps assigned to the chromatography cycle are at least partly being synchronized with each other by the process control in synchronization routines based on assigned synchronization strategies.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
Systems and methods for characterizing a physical and solution properties of liquids are described. In some embodiments, an ultrasonic interrogation signal may be emitted into a liquid such as a solubilized protein solution. A resulting ultrasonic spectrum may be sensed and provided to a trained statistical model of the solution. The trained statistical model may then determine one or more properties of the liquid. In some embodiments, the trained statistical model determines a viscosity of the liquid and/or a solubilized protein concentration of the liquid. In some embodiments, a trained statistical classification model configured to classify the liquid based, for example, on its contents or properties is used to improve modeling accuracy.
The invention relates to a centrifuge, in particular a continuous flow centrifuge, a biotechnical centrifuge or a blood centrifuge. The centrifuge comprises a refrigerant circuit. According to the invention, the outlet side of a controllable compressor is connected to an inlet side of an evaporator via a bypass line with a valve arranged therein. In a normal operation mode, a centrifuge vessel is cooled exclusively via the control of the compressor and an expansion unit while the valve is closed. If, on the other hand, a tolerance range of the target temperature in the centrifuge vessel is left, the valve is opened in order to bring about heating and thus a return of the temperature in the centrifuge vessel to the tolerance range.
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Filter modules, namely, filter capsules, filter candles, filter cassettes, coil modules, filter coils, filter coils in connection with filter centrifuges, band filters, small filters, small filters in connection with centrifuge tubes and as centrifugal concentrators, disposable filters; Membrane filters and filter matting being parts of machines, for use in biotechnology, environmental protection, for the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and for use in genetic engineering, medicine and in laboratories, and for treatment and analysis of water and effluent; Filters being parts of machines; Membrane filters for use as part of machines. Laboratory filters; Filtering units for laboratory use; Liquid filter units, namely, filter cartridges, plastic hoses and hose connectors sold as a set for laboratory use; Membranes for filtration [scientific]; Filters for use with laboratory chromatography apparatus; Membrane filters and filter matting with adsorption properties, membrane adsorbers, namely adsorption membranes, ion exchange membranes, ligand membranes and activated membranes in the form of hollow fibre membranes, tube membranes and flat membranes as strips or cut to size for use in apparatus, filters and filter modules for the aforesaid fields of application; Membrane filters and filter matting as parts of microtitre plates; Membrane filters and filter matting as parts of diagnostic tests such as diagnostic assays and immunoassays; Membrane filters and filter matting as parts of filter systems or as independent filters for chromatographic analyses and chemical separation, reconcentration, for sterilisation and ultrapurification of fluids; Filters and filter modules for filtering and reconcentration of biological solutions, namely of viral and bacterial suspensions; Filters and filter modules for treating blood and other bodily fluids. Filters and filtering units, for industrial use; Filters for filtering fluids, filter modules, filter candles and filter capsules; Liquid filter units, namely, filter cartridges, plastic hoses and hose connectors, sold as a set, for industrial installations; Filters for water filtering apparatus; Cartridge filtration units [water treatment equipment]; Filters for use with industrial chromatography apparatus; Apparatus for water treatment and for preparing solutions in the pharmaceutical, medical and laboratory fields; Equipment for de-ionising water; Equipment for de-pyrogenisation of solutions and for separating harmful substances from fluids; Filters and filter modules for desalination of protein solutions and other biological media; Filters and filter modules for analysis and separation of ions, macromolecules and biomolecules, namely carbohydrates, peptides, proteins and nucleic acids and for separating heavy metals and harmful substances from fluids; Filters for industrial use, namely, membrane filters and filter matting having applications in biotechnology, environmental protection, the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and in genetic engineering, medicine and laboratories, and the treatment and analysis of water and effluents.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific and technological research services in the field of biopharmaceuticals, specifically relating to bioprocess optimization, including media and buffer preparation, seed train, filtration, chromatography, and virus clearance; design and development of computer software for biopharmaceutical process automation and control; technical consultancy services related to biopharmaceutical process optimization, focusing on bioprocess steps namely, filtration, chromatography, and virus clearance; software as a service (SaaS) for biopharmaceutical manufacturing, including media and buffer preparation, seed train, filtration, chromatography, polishing and virus clearance; IT services in relation to cloud-based interfaces for managing biopharmaceutical manufacturing processes, namely, interfaces for filtration, purification, and virus clearance systems; testing and validation services for bioprocessing equipment and systems; process scale-up technical consulting and technical support for biopharmaceutical production.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Scientific and technological research services in the field of biopharmaceuticals, specifically relating to bioprocess optimization, including media and buffer preparation, seed train, filtration, chromatography, and virus clearance; design and development of computer software for biopharmaceutical process automation and control; technical consultancy services related to biopharmaceutical process optimization, focusing on bioprocess steps namely, filtration, chromatography, and virus clearance; software as a service (SaaS) for biopharmaceutical manufacturing, including media and buffer preparation, seed train, filtration, chromatography, polishing and virus clearance; IT services in relation to cloud-based interfaces for managing biopharmaceutical manufacturing processes, namely, interfaces for filtration, purification, and virus clearance systems; testing and validation services for bioprocessing equipment and systems; process scale-up technical consulting and technical support for biopharmaceutical production.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
07 - Machines et machines-outils
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
37 - Services de construction; extraction minière; installation et réparation
Produits et services
(1) Chemicals and reagents for use in media and buffer preparation, seed train, filtration, chromatography, and virus clearance in biotechnology and biopharmaceutical industries; chemicals for industrial and laboratory use in biopharmaceutical processing, including those for filtration and purification of biological materials.
(2) Machinery and automated equipment for media and buffer preparation, seed train, filtration, chromatography, and polishing; industrial robots and apparatus for bioprocessing and manufacturing including filtration systems for the purification and separation of biological substances.
(3) Scientific, research, and laboratory apparatus for use in biopharmaceutical manufacturing, namely, apparatus for media and buffer preparation, seed train and production, filtration, chromatography, polishing and virus clearance; downloadable and recorded software for biopharmaceutical processes, namely, software for media preparation, buffer preparation, seed train optimization, filtration, chromatography, polishing, and virus clearance; control systems and software for automating biopharmaceutical processes, namely, software for filtration and purification processes; interfaces and human-machine interface (HMI) software for managing and optimizing biopharmaceutical processes; data collection and management software for process intensification systems; devices for real-time monitoring and optimization for biopharmaceutical production.
(4) Industrial filtration apparatus for water, air, and gas purification; chromatography apparatus for biopharmaceutical purification; process systems and equipment for the filtration, purification, and separation of biological substances in biopharmaceutical processes, namely, filtration systems for bioprocessing. (1) Installation and maintenance of process intensification systems for biopharmaceutical production.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
07 - Machines et machines-outils
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
37 - Services de construction; extraction minière; installation et réparation
Produits et services
Chemicals and reagents for use in media and buffer preparation, seed train, filtration, chromatography, and virus clearance in biotechnology and biopharmaceutical industries; chemicals for industrial and laboratory use in biopharmaceutical processing, including those for filtration and purification of biological materials. Machinery and automated equipment for media and buffer preparation, seed train, filtration, chromatography, and polishing; industrial robots and apparatus for bioprocessing and manufacturing including filtration systems for the purification and separation of biological substances. Scientific, research, and laboratory apparatus for use in biopharmaceutical manufacturing, namely, apparatus for media and buffer preparation, seed train and production, filtration, chromatography, polishing and virus clearance; downloadable and recorded software for biopharmaceutical processes, namely, software for media preparation, buffer preparation, seed train optimization, filtration, chromatography, polishing, and virus clearance; control systems and software for automating biopharmaceutical processes, namely, software for filtration and purification processes; interfaces and human-machine interface (HMI) software for managing and optimizing biopharmaceutical processes; data collection and management software for process intensification systems; devices for real-time monitoring and optimization for biopharmaceutical production. Industrial filtration apparatus for water, air, and gas purification; chromatography apparatus for biopharmaceutical purification; process systems and equipment for the filtration, purification, and separation of biological substances in biopharmaceutical processes, namely, filtration systems for bioprocessing. Installation and maintenance of process intensification systems for biopharmaceutical production.
A device assembly including a single-use device for sensing or influencing a parameter of a running bioprocess. The single-use device is configured to have at least two different defined functional states, a first functional state being an inactive delivery state in which the single-use device is sterile and inoperable according to its intended use, and a second functional state being an active use state in which the single-use device is operable according to its intended use. The device assembly further includes a signalling element for indicating a current functional state of the single-use device to a user. Each functional state is associated with a distinct signal. The device assembly is configured such that a transfer from the first functional state to any other functional state of the single-use device is irreversible and/or permanently prevents the signalling element from indicating the signal associated with the first functional state.
A method of harvesting cell broth (12) from a mixing device (10) for mixing the cell broth (12) of a rocking motion bioreactor is shown. The mixing device (10) comprises a rocking motion platform (14), a mixing bag (18) and a processing unit (22). After a harvest process is started, the mixing bag (18) is tilted into a default harvest position and the cell broth (12) is harvested in the default harvest position of the mixing bag (18). If a pause condition is fulfilled, harvesting is paused and the mixing device starts rocking at a defined speed and a defined rocking angle for a predetermined time. After the predetermined time, harvesting in the default harvest position is resumed. Furthermore, a mixing device (10) for mixing cell broth (12) is disclosed.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
B01F 27/80 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins avec des agitateurs tournant autour d'un axe sensiblement vertical
44.
METHOD OF CONTROLLING A BIOPHARMACEUTICAL PURIFICATION PROCESS
A method of controlling a biopharmaceutical purification process, preferably a continuous process, making use of a separation arrangement. The separation arrangement preferably includes multiple chromatography columns or filtration devices. The method comprises the following steps: repeatedly acquiring an absorption spectrum inline or online at a fluid stream with a detector which is capable of recording spectra within a wavelength range between 190 nm and 2400 nm, preferably between 190 nm and 390 nm or 190 nm and 780 nm or 1100 nm and 2400 nm; real-time processing of the acquired spectrum; and real- time monitoring and controlling the process based on the processed spectrum. The step of processing includes at least one of the following measures: reducing noise; reducing spectral interference; correcting the acquired spectrum for scattering effects and/or other background effects.
G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
45.
ON-LINE BIOMOLECULAR ANALYSIS FOR MONITORING OR CONTROLLING BIOPROCESSES
The disclosure relates to monitoring or controlling bioprocesses by way of withdrawing discrete fluid samples from a reactor and performing on-line analysis of said sample using a fluidic manifold, for example, by way of a sensor based on label-free biomolecular interaction analysis. The disclosure relates to a system for measuring one or more analytes in discrete fluid samples from a vessel adapted to contain a fluid having one or more sensors for the measurement of the analytes in a contact volume of the fluid sample. An analysis module having at least one main sampling line in fluidic connection with the vessel and one or more pumps in fluidic connection with said main sampling line(s) and adapted to selectively pump fluid from in the main sampling line away from the vessel. At least one fluid distribution tubing in fluidic connection with the analysis module. A manifold has a body.
C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
46.
METHOD AND DEVICE FOR AUTOMATING THE FOAM CONTROL IN A BIOREACTOR
The invention relates to a method for automating the foam regulation during a bioprocess for cultivating cells in a bioreactor, said method comprising the following steps: determining values of one or more process variables of the bioprocess which is/are relevant for the formation of foam in the bioreactor; transferring the determined values as input signals to a controller; generating, by the controller, output signals for at least one foam regulation device depending on the input signals; and controlling the at least one foam regulation device in a requirements-oriented manner by means of the output signals output by the controller.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
47.
COUPLING DEVICE FOR COUPLING TO A DIAPHRAGM DEVICE, DIAPHRAGM DEVICE AND METHOD
A coupling device (1) for coupling to a flexible diaphragm (51) of a diaphragm device (50) and comprising a base structure (10) for attaching the diaphragm device (50) thereto; an actuator structure (20) mounted movable along an actuation direction (A) relative to the base structure (10) and having a diaphragm grasping element (22) pivotably mounted between a release position and a grasping position for coupling the actuator structure (20) to the flexible diaphragm (51) in the grasping position; and a fixation structure (30) mounted movable along a fixation direction (F) relative to the base structure (10) between an open position and a closed position and designed to fix in the closed position the diaphragm grasping element (22) against leaving the grasping position.
F16K 1/48 - Fixation des corps de soupapes aux tiges des soupapes
F16K 7/16 - Dispositifs d'obturation à diaphragme, p. ex. dont un élément est déformé, sans être déplacé entièrement, pour fermer l'ouverture à diaphragme plat, en forme d'assiette ou en forme de bol disposé pour être déformé contre un siège plat le diaphragme étant actionné mécaniquement, p. ex. par une tige filetée ou par came
F16L 37/127 - Accouplements du type à action rapide dans lesquels l'assemblage entre les extrémités s'aboutant ou se chevauchant est maintenu par des organes de blocage utilisant des crochets, cliquet, ou autres organes de blocage mobiles ou que l'on peut insérer utilisant des crochets articulés autour d'un axe
A membrane for microbiological analysis, a production method of a membrane for microbiological analysis, and the use of such membranes for microbiological analysis. Examples include a cellulose membrane for microbiological analysis that is impregnated with a non-ionic surfactant in an amount of from 100 ng/cm2 to 1.0 mg/cm2, with the membrane having a nominal pore size of from 0.20 μm to 0.80 μm, and a cumulative adsorption pore volume of less than 0.010 cm3/g.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
17 - Produits en caoutchouc ou en matières plastiques; matières à calfeutrer et à isoler
Produits et services
Filter modules, namely filter capsules, filter candles,
filter cassettes, coil modules, filter coils, filter coils
in connection with filter centrifuges, band filters, small
filters, small filters in connection with centrifuge tubes
and as centrifugal concentrators, disposable filters;
membrane filters and filter matting being parts of machines,
for use in biotechnology, environmental protection, for the
drinks, food, luxury items, pharmaceutical, cosmetics,
electronics and general chemical industries, and for use in
genetic engineering, medicine and in laboratories, and for
treatment and analysis of water and effluent; filters being
parts of machines; membrane filters for use as part of
machines. Laboratory filters; filtering units for laboratory use;
liquid filter units, namely, filter cartridges, plastic
hoses and hose connectors sold as a set for laboratory use;
membranes for filtration (laboratory use); filters for use
with laboratory chromatography apparatus; membrane filters
and filter matting for laboratories with adsorption
properties, membrane adsorbers, namely adsorption membranes,
ion exchange membranes, ligand membranes and activated
membranes in the form of hollow fibre membranes, tube
membranes and flat membranes as strips or cut to size for
use in apparatus, filters and filter modules for the
aforesaid fields of application; membrane filters and filter
matting as parts of microtitre plates; membrane filters and
filter matting as parts of diagnostic tests such as
diagnostic assays and immunoassays; membrane filters and
filter matting as parts of filter systems or as independent
filters for chromatographic analyses and chemical
separation, reconcentration, for sterilisation and
ultrapurification of fluids; filters and filter modules for
filtering and reconcentration of biological solutions,
namely of viral and bacterial suspensions; filters and
filter modules for treating blood and other bodily fluids. Air filters and filtering units, for industrial use; liquid
filters and filtering units, for industrial use; filters for
filtering fluids, filter modules, filter candles and filter
capsules; liquid filter units, namely, filter cartridges,
plastic hoses and hose connectors, sold as a set, for
industrial installations; filters for water filtering
apparatus; cartridge filtration units [water treatment
equipment]; filters for use with industrial chromatography
apparatus; apparatus for water treatment and for preparing
solutions in the pharmaceutical, medical and laboratory
fields; equipment for de-ionising water; equipment for
de-pyrogenisation of solutions and for separating harmful
substances from fluids; filters and filter modules for
desalination of protein solutions and other biological
media; filters and filter modules for analysis and
separation of ions, macromolecules and biomolecules, namely
carbohydrates, peptides, proteins and nucleic acids and for
separating heavy metals and harmful substances from fluids;
filters for industrial use, namely, membrane filters and
filter matting having applications in biotechnology,
environmental protection, the drinks, food, luxury items,
pharmaceutical, cosmetics, electronics and general chemical
industries, and in genetic engineering, medicine and
laboratories, and the treatment and analysis of water and
effluents. Membranes and semi-processed synthetic filtering materials;
polymeric membranes; polymeric porous membranes in hollow
fibre form; polymeric porous membranes in sheet form;
transfer membranes of cellulose derivatives; transfer
membranes of cellulose; transfer membranes of polyamides;
transfer membranes of polyvinylidene fluoride; cross-linked
polymeric membranes in sheet form; cross-linked polymeric
membranes in hollow fibre form.
50.
METHOD FOR PERFORMING A TANGENTIAL FLOW FILTRATION ON A BIOMOLECULAR SOLUTION
The invention relates to a method for performing a tangential flow filtration on a biomolecular solution, in particular for performing a single pass tangential flow filtration on a biomolecular solution, as part of a production process for biomolecules, wherein a tangential flow filtration arrangement (1) is provided, wherein the tangential flow filtration arrangement (1) comprises a tangential flow filtration module (2), wherein the tangential flow filtration is performed inside the tangential flow filtration module (2), wherein the tangential flow filtration module (2) comprises a filter (3), a feed input fluid line (4) for the biomolecular solution as a feed medium, a retentate output fluid line (6) for a retentate, a filtrate output fluid line (7) for a filtrate, and preferably a buffer input fluid line (5) for a buffer, wherein the tangential flow filtration arrangement (1) comprises at least two actuators (8) influencing the tangential flow filtration, wherein the tangential flow filtration arrangement (1) comprises a control module (10), wherein the control module (10) controls the tangential flow filtration by providing control signals to the actuators (8) and measuring at least two measured variables (11) describing the tangential flow filtration, wherein the control module (10) uses a process control to control the tangential flow filtration. It is proposed that the process control is a model predictive control (13), that the control module (10) inputs the measured variables (11) as input variables (14) into the model and derives at least two manipulated variables (15) as control signals for the actuators (8).
The invention relates to a device for continuous virus inactivation during a protein production process, in particular an antibody production process, wherein the device comprises an axially extending hollow-body holder (1) for holding an elongated, elastically deformable hollow body (2), in particular a flexible tube, wherein the device comprises at least two axially extending rollers (3, 4), in particular three or four rollers (3, 4, 5, 6), each of which, when the device has been assembled as intended, squeezes the hollow body (2) and thereby divides the internal volume (7) of the hollow body (2) into volume portions (8) fluidically separated from one another, wherein the continuous virus inactivation is carried out in the volume portions (8) of the hollow body (2). It is proposed that the device comprises a support element (9) which, when the device has been assembled as intended, supports the lateral faces of each of the rollers (3, 4, 5, 6) in at least one point.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
B01D 15/24 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au traitement des fractions à répartir
52.
METHOD OF OPERATING A BIOPROCESSING ARRANGEMENT COMPRISING A CLARIFICATION SET-UP TO REMOVE CELL DEBRIS FROM A CELL BROTH
The invention relates to a method of operating a bioprocessing arrangement (1) comprising a clarification set-up (2) to remove cell debris from a cell broth (10), wherein the clarification set-up (2) comprises a fluidized bed centrifuge (8) with at least one centrifuge chamber (11), wherein the cell broth (10) is separated into at least a waste fraction (12) and an output fraction (13), wherein the separation of the cell broth (10) into the waste fraction (12) and the output fraction (13) comprises a loading step (14) during which the centrifuge chamber (11) is loaded with cells of the cell broth (10) up to a capacity below or equal to a maximum cell loading capacity of the centrifuge chamber (11), an overloading step (15) during which the centrifuge chamber (11) is further loaded with cell broth (10), thereby flushing out cells from the centrifuge chamber (11), collecting cells flushed out during the overloading step (15) as the waste fraction (12), and collecting cells from the chamber as the output fraction (13).
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Laboratory filters; filtration membranes for laboratory use;
laboratory filtration apparatus and filtering materials for
the filtration of liquids and gases; filters, for use in
relation to the following goods: laboratory apparatus in the
biopharmaceutical industry; filtration systems, devices, and
membranes for laboratory use. Filters for industrial use, namely for liquids, gases, and
biopharmaceutical applications; filtration units; filtration
units, namely filter cartridges, filter capsules, filter
modules, filter capsules and disposable filters, for
industrial purposes; filters, namely small filters,
disposable filters, filter cartridges, filter modules and
diaphragm filters being parts of filtering units or being
independent filters, for sterilisation and purification of
liquids and gases in the beverage, food and general chemical
industry; filters, specifically filter cartridges and
membrane filters for single use as parts of filter systems
or as stand-alone filters for the sterilization and
purification of liquids and gases in the electronics,
pharmaceutical, food, beverage, luxury food, cosmetics and
general chemical industries.
54.
SEPARATION SYSTEM AND METHOD FOR SEPARATING AND PURIFYING A TARGET COMPONENT
A separation system for separating and purifying a target component, a method for separating and purifying a target component, and the use of a crossflow diafiltration unit for processing a target phase. The system includes an aqueous-two phase extraction unit for aqueous-two phase extraction of the fluid, a separation unit for separating a target phase, and a crossflow diafiltration unit.
A smart single-use tube line assembly for use in a unit operation of a bioprocess including at least one tube line. The tube line includes a tube body surrounding a lumen through which a medium can flow. The tube line assembly also includes a functional element embedded in the tube body, the functional element being configured to perform an optical and/or electrical function. The tube line assembly further includes an interface for coupling both the lumen and the functional element of the tube line to another component. The tube line assembly still further includes a control unit for controlling the optical and/or electrical function.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
The invention relates to a an aeration device for a bioprocessing installation (2), comprising a housing (4), a circumferential rigid body (5), wherein the housing (4) comprises at least a first aeration channel (7) and a second aeration channel (8), wherein the housing (4) further comprises at least a first gas inlet port (10) and a second gas inlet port (11), and wherein the housing (4) further comprises a plurality of first gas discharge openings (12) and second gas discharge openings (13). It is proposed that the first aeration channel (7) and the second aeration channel (8) are arranged so as to overlap one another in the axial direction at least in sections.
B01F 23/231 - Mélange de gaz avec des liquides en introduisant des gaz dans des milieux liquides, p. ex. pour produire des liquides aérés par barbotage
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
A clamping device for fluidically and mechanically connecting two hose barbs. The clamping device includes a seal and a locking mechanism, wherein the locking mechanism can be transferred from a mounting condition to an assembled condition. In the mounting condition, the hose barbs can be inserted into the clamping device, while in the assembled condition, those hose barbs are locked in place in a position in which free ends of the hose barbs face each other and a seal coaxially aligns and fluid-tightly connects the free ends.
F16L 33/22 - Dispositions d'assemblage des manches avec des organes rigidesRaccords rigides pour manches, p. ex. éléments unitaires s'engageant à la fois dans deux manches avec moyens non mentionnés dans les groupes précédents pour saisir la manche entre l'extérieur et l'intérieur
F16L 33/18 - Dispositions d'assemblage des manches avec des organes rigidesRaccords rigides pour manches, p. ex. éléments unitaires s'engageant à la fois dans deux manches caractérisées par l'emploi de moyens d'étanchéité additionnels
58.
FILTRATION DEVICE, IN PARTICULAR SMALL-SCALE FILTRATION DEVICE FOR PRODUCTION OF BIOPHARMACEUTICALS
A filtration device (10), in particular a small-scale filtration device for production of biopharmaceuticals, comprises a housing including a top cover (12) having an unfiltrate inlet (18) and a bottom cover (14) having a filtrate outlet (22), and one or more filter supports (16) stacked between the top cover (12) and the bottom cover (14) along a vertical direction such that an upper side of each filter support (16) faces the top cover (12) and a lower side of each filter support (16) faces the bottom cover (14). Each filter support (16) is equipped with a flat upper filter (40) and a flat lower filter (42). Each filter (40, 42) has a filtrate side and an opposite unfiltrate side. The upper and lower filters (40, 42) are sealed to the upper and lower sides of the filter support (16), respectively, with the filtrate sides facing the filter support (16) and the unfiltrate sides facing away from the filter support (16). Unfiltrate flow paths lead from the unfiltrate inlet of the top cover (12) to the unfiltrate side of the upper filter (40) and to the unfiltrate side of the lower filter (42), wherein blocking means prevent unfiltrate from flowing directly from the unfiltrate inlet of the top cover (12) to the filtrate outlet (22) of the bottom cover (14). Filtrate flow paths lead from the filtrate sides of the upper and lower filters (40, 42) to the filtrate outlet (22) of the bottom cover (14) via at least one filtrate guiding channel (48a, 48b) formed on the upper side of the filter support (16) and at least one filtrate guiding channel (48a, 48b) formed on the lower side of the filter support (16). The upper filter (40) and the lower filter (42) are identically shaped.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
B01D 69/10 - Membranes sur supportSupports pour membranes
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Laboratory filters; filtration membranes for laboratory use; laboratory filtration apparatus and filtering materials for the filtration of liquids and gases; filters, for use in relation to the following goods: laboratory apparatus in the biopharmaceutical industry; filtration systems, devices, and membranes for laboratory use. Filters for industrial use, namely for liquids, gases, and biopharmaceutical applications; filtration units; filtration units, namely filter cartridges, filter capsules, filter modules, filter capsules and disposable filters, for industrial purposes; filters, namely small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries.
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
(1) Laboratory filters; filtration membranes for laboratory use; laboratory filtration apparatus and filtering materials for the filtration of liquids and gases; filters, for use in relation to the following goods: laboratory apparatus in the biopharmaceutical industry; filtration systems, devices, and membranes for laboratory use.
(2) Filters for industrial use, namely for liquids, gases, and biopharmaceutical applications; filtration units; filtration units, namely filter cartridges, filter capsules, filter modules, filter capsules and disposable filters, for industrial purposes; filters, namely small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries.
61.
METHOD AND SYSTEM FOR TESTING THE INTEGRITY OF FILTERS
A method for testing integrity of a filter can include pressurizing an upstream side of the filter to a test pressure and performing a check step that includes determining a flow rate of fluid from the upstream side to a downstream side of the filter, comparing the determined flow rate with a flow range including a flow threshold, and setting stop criteria based on the comparison.
The present invention relates to a method for treating an ultrafiltration membrane, a method for producing an ultrafiltration membrane comprising the treatment method, as well as ultrafiltration membrane obtained by the treatment method or the production method.
A modular processing system (100) for biopharmaceutical processes includes (i) at least one first and at least one second processing unit (30, 32), which can be fluidically connected to each other; and (ii) at least one adapter plate (200), through which at least one fluid flow (14), flowing from the first processing unit (30) to the second processing unit (32), can flow. The adapter plate deflects the fluid flow between the first processing unit and the second processing unit at least partially; and/or controls the fluid flow, preferably, the pressure thereof, in an open loop or closed loop manner. A method for the modular construction of a processing system (100) for biopharmaceutical processes is also disclosed.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
07 - Machines et machines-outils
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
37 - Services de construction; extraction minière; installation et réparation
Produits et services
Chemicals and reagents for use in media and buffer preparation, seed train, filtration, chromatography, and virus clearance in biotechnology and biopharmaceutical industries; Chemicals for industrial and laboratory use in biopharmaceutical processing, including those for filtration and purification of biological materials. Machinery and automated equipment for media and buffer preparation, seed train, filtration, chromatography, and polishing; Industrial robots and apparatus for bioprocessing and manufacturing including filtration systems for the purification and separation of biological substances. Scientific, research, and laboratory apparatus for use in biopharmaceutical manufacturing, namely, apparatus for media and buffer preparation, seed train and production, filtration, chromatography, polishing and virus clearance; Downloadable and recorded software for biopharmaceutical processes, namely, software for media preparation, buffer preparation, seed train optimization, filtration, chromatography, polishing, and virus clearance; Control systems and software for automating biopharmaceutical processes, namely, software for filtration and purification processes; Interfaces and human-machine interface (HMI) software for managing and optimizing biopharmaceutical processes; Data collection and management software for process intensification systems; Devices for real-time monitoring and optimization for biopharmaceutical production. Industrial filtration apparatus for water, air, and gas purification; Chromatography apparatus for biopharmaceutical purification; Process systems and equipment for the filtration, purification, and separation of biological substances in biopharmaceutical processes, namely, filtration systems for bioprocessing. Installation and maintenance of process intensification systems for biopharmaceutical production.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific and technological research services in the field of biopharmaceuticals, specifically relating to bioprocess optimization, including media and buffer preparation, seed train, filtration, chromatography, and virus clearance; Design and development of computer software for biopharmaceutical process automation and control; Technical consultancy services related to biopharmaceutical process optimization, focusing on bioprocess steps namely, filtration, chromatography, and virus clearance; Software as a service (SaaS) for biopharmaceutical manufacturing, including media and buffer preparation, seed train, filtration, chromatography, polishing and virus clearance; IT-services in relation to cloud-based interfaces for managing biopharmaceutical manufacturing processes, namely, interfaces for filtration, purification, and virus clearance systems; Testing and validation services for bioprocessing equipment and systems; Process scale-up technical consulting and technical support for biopharmaceutical production.
The invention relates to a portable container holder for use in a bioprocess for holding and transporting a disposable container (3) which is filled with a fluid (2) and which has received a magnetically driven mixing element (4) for mixing the fluid (2), wherein the portable container holder (1) has a container receiving area (7) for receiving the disposable container (3), said receiving area having a drive location (8) where the mixing element (4) can be arranged in the disposable container (3) received in the container receiving area (7) such that the mixing element (4) can be driven by a drive unit (9) at the drive location (8). According to the invention, the portable container holder (1) has a transport securing unit (11) for securing and releasing the mixing element (4), which is arranged at the drive location (8), in its position, and the transport securing unit (11) has a magnet (10) which can be moved between a defined securing position (12), in which the mixing element (4) is secured in its position, and a defined release position (13), in which the mixing element (4) is released from its position.
The invention relates to a portable container holder for use in a bioprocess for holding and transporting a flexible disposable container (3) which is filled with a fluid (2). In particular, the fluid (2) is a fluid (2) which contains a purified pharmaceutical ingredient or a cultivation medium, and the portable container holder (1) has a container receiving area (6) for receiving the disposable container (3) and a cover (7) which can be installed on the container receiving area (6) in order to cover (7) the disposable container (3) received in the container receiving area (6), wherein the cover (7) has a fixing assembly (8) via which the disposable container (3) filled with the fluid (2) can be fixed in the container receiving area (6) in the installed state of the cover (7). According to the invention, the cover (7) has a spring assembly (9) which elastically supports the fixing assembly (8), and a spring force can be applied to the fixing assembly (8) in the direction of the spring via the spring assembly (9) in the installed state of the cover (7).
A device arrangement for separating cells from a culture medium in a bioprocess, in particular in a biopharmaceutical process, including a storage tank for the culture medium; a filtration module having a membrane adapted to be overflowed; an intake line connecting the storage tank to an unfiltrate inlet for supplying culture medium into the filtration module; a return line which connects a retentate-side outlet of the filtration module to the storage tank for returning retentate into the storage tank; a filtrate line which is connected to a permeate-side outlet of the filtration module for discharging filtrate; a first pump for maintaining a recirculation circuit; a backflush line which leads to a permeate-side connection and/or to the permeate-side outlet for supplying a rinsing liquid into the filtration module; and a second pump for conveying the rinsing liquid into the filtration module. A method of separating cells from a culture medium.
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
17 - Produits en caoutchouc ou en matières plastiques; matières à calfeutrer et à isoler
Produits et services
Filter modules, namely filter capsules, filter candles, filter cassettes, coil modules, filter coils, filter coils in connection with filter centrifuges, band filters, small filters, small filters in connection with centrifuge tubes and as centrifugal concentrators, disposable filters; membrane filters and filter matting being parts of machines, for use in biotechnology, environmental protection, for the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and for use in genetic engineering, medicine and in laboratories, and for treatment and analysis of water and effluent; filters being parts of machines; membrane filters for use as part of machines. Laboratory filters; filtering units for laboratory use; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors sold as a set for laboratory use; membranes for filtration (laboratory use); filters for use with laboratory chromatography apparatus; membrane filters and filter matting for laboratories with adsorption properties, membrane adsorbers, namely adsorption membranes, ion exchange membranes, ligand membranes and activated membranes in the form of hollow fibre membranes, tube membranes and flat membranes as strips or cut to size for use in apparatus, filters and filter modules for the aforesaid fields of application; membrane filters and filter matting as parts of microtitre plates; membrane filters and filter matting as parts of diagnostic tests such as diagnostic assays and immunoassays; membrane filters and filter matting as parts of filter systems or as independent filters for chromatographic analyses and chemical separation, reconcentration, for sterilisation and ultrapurification of fluids; filters and filter modules for filtering and reconcentration of biological solutions, namely of viral and bacterial suspensions; filters and filter modules for treating blood and other bodily fluids. Air filters and filtering units, for industrial use; liquid filters and filtering units, for industrial use; filters for filtering fluids, filter modules, filter candles and filter capsules; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors, sold as a set, for industrial installations; filters for water filtering apparatus; cartridge filtration units [water treatment equipment]; filters for use with industrial chromatography apparatus; apparatus for water treatment and for preparing solutions in the pharmaceutical, medical and laboratory fields; equipment for de-ionising water; equipment for de-pyrogenisation of solutions and for separating harmful substances from fluids; filters and filter modules for desalination of protein solutions and other biological media; filters and filter modules for analysis and separation of ions, macromolecules and biomolecules, namely carbohydrates, peptides, proteins and nucleic acids and for separating heavy metals and harmful substances from fluids; filters for industrial use, namely, membrane filters and filter matting having applications in biotechnology, environmental protection, the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and in genetic engineering, medicine and laboratories, and the treatment and analysis of water and effluents. Membranes and semi-processed synthetic filtering materials; polymeric membranes; polymeric porous membranes in hollow fibre form; polymeric porous membranes in sheet form; transfer membranes of cellulose derivatives; transfer membranes of cellulose; transfer membranes of polyamides; transfer membranes of polyvinylidene fluoride; cross-linked polymeric membranes in sheet form; cross-linked polymeric membranes in hollow fibre form.
71.
PRODUCT FOR PROVIDING MEMBRANE ELEMENTS AND MANUFACTURING METHOD
The invention relates to a product for providing membrane elements, comprising: a carrier film; and a membrane film, at least comprising: a support layer; and a membrane layer; the membrane film is releasably coupled to the carrier film; and the membrane film has a plurality of substantially discrete membrane elements. The invention also relates to a corresponding manufacturing process.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B32B 3/30 - Produits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche continue dont le périmètre de la section droite a une allure particulièreProduits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche comportant des cavités ou des vides internes caractérisés par une couche comportant des retraits ou des saillies, p. ex. des gorges, des nervures
B32B 7/06 - Liaison entre couches permettant une séparation sans difficultés
B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
B32B 23/06 - Produits stratifiés composés essentiellement de substances cellulosiques plastiques comprenant de telles substances comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique de papier ou de carton
B32B 23/08 - Produits stratifiés composés essentiellement de substances cellulosiques plastiques comprenant de telles substances comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique de résine synthétique
B32B 23/20 - Produits stratifiés composés essentiellement de substances cellulosiques plastiques comprenant des esters
B32B 27/08 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique d'une résine synthétique d'une sorte différente
B32B 27/10 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique de papier ou de carton
B32B 27/28 - Produits stratifiés composés essentiellement de résine synthétique comprenant des copolymères de résines synthétiques non complètement couverts par les sous-groupes suivants
B32B 37/12 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par l'usage d'adhésifs
B32B 37/18 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par les propriétés des couches toutes les couches existant et présentant une cohésion avant la stratification impliquant uniquement l'assemblage de feuilles ou de panneaux individualisés
B32B 38/10 - Enlèvement de couches ou de parties de couches, mécaniquement ou chimiquement
72.
BIOPROCESS SYSTEM FOR A BIOPROCESS OPERATION WITH A DISPLAY ARRANGEMENT FOR DISPLAYING SYSTEM INFORMATION ABOUT THE BIOPROCESS SYSTEM
The invention relates to a bioprocess system for a bioprocess operation with a display arrangement (21) for displaying system information about the bioprocess system (1), wherein the bioprocess system (1) comprises system components (6) comprising at least one monitored system component (22), wherein the system components (6) can be assembled into an assembled state in which the bioprocess system (1) is operational for the bioprocess operation and can be disassembled into a disassembled state in which the bioprocess system (1) is not operational for the bioprocess operation, wherein the bioprocess system (1) comprises a control arrangement (24) and the display arrangement (21) comprises at least one display component (25), wherein in an assembled state of the bioprocess system (1) during a bioprocess operation the control arrangement (24) displays process information via the display arrangement (21) and/or wherein during assembly of the bioprocess system (1) the control arrangement (24) displays assembly information via the display arrangement (21), wherein the process information and/or the assembly information concern at least the monitored system component (22) and wherein the display arrangement (21) comprises at least one display component (25). It is proposed that the display component (25) comprises a light emitting element (27) arranged separate from the monitored system component (22) and arranged next to or on the monitored system component (22) and that the control arrangement (24) is configured to display via the light emitting element (27) the process information and/or the assembly information relating to the monitored system component (22).
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
G05B 19/409 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par l'utilisation de l'entrée manuelle des données [MDI] ou par l'utilisation d'un panneau de commande, p. ex. commande de fonctions avec le panneauCommande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par les détails du panneau de commande ou par la fixation de paramètres
G06F 9/448 - Paradigmes d’exécution, p. ex. implémentation de paradigmes de programmation
G05B 19/40 - Systèmes à boucle ouverte, p. ex. utilisant un moteur pas à pas
G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
The invention relates to a method for inactivating viruses in a fluid, in which method: a starting fluid (AF) containing active viruses is mixed with a virus-inactivating reagent (R1) in a first mixing assembly (2) to form a reactive fluid (F); the active viruses are inactivated via incubation of the reactive fluid (F); and the inactivation of the viruses in the reactive fluid (F) is stopped by mixing the reactive fluid (F) with a further reagent (R2) or by removing the virus-inactivating reagent (R1) from the reactive fluid (F), as a result of which a resulting fluid (RF) is produced. According to the invention, the active viruses are inactivated via incubation of the reactive fluid (F) in a container assembly (3) which comprises a plurality of separate containers (4) and differs from the first mixing assembly (2), wherein the reactive fluid (F) is conducted from the first mixing assembly (2) to the container assembly (3) prior to incubation.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
The invention relates to a method for generating and purifying viral vectors (V), wherein the viral vectors (V) are generated by cells in a fluid (F) and wherein the fluid (F) comprising the viral vectors (V) is guided through a tangential flow filtration arrangement (2) for purification, whereby the viral vectors (V) are purified in the fluid (F). It is proposed that the cells and cell debris from the cells, which are contained in the fluid (F) comprising the viral vectors (V) after generating the viral vectors (V), are at least partially separated from the viral vectors (V) by a fluidized bed centrifuge (5) before purification by the tangential flow filtration arrangement (2).
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci
The present invention relates to methods for the purification of viruses, virus-like particles, extracellular vesicles, proteins having a diameter of 5 nm or more, protein complexes having a diameter of 5 nm or more, nucleic acids having a diameter of 5 nm or more, protein-nucleic acid complexes having a diameter of 5 nm or more, and/or molecules having a diameter of 5 nm or more, by filtration-supported polyalkylene glycol precipitation, and to filtration modules that can be used in said methods.
Embodiments include a device for continuous virus inactivation during a protein production process comprising a first and a second fluid inlet, a first mixer, and a fluid outlet. A first liquid stream containing a target protein is introducible into the device through the first fluid inlet and is combinable in a predefined volume ratio with a second, virus-inactivating liquid stream introducible into the device through the second fluid inlet to form a third, reactive liquid stream which is conducted through the first mixer for mixing in order to generate predefined, virus-inactivating conditions. The device further comprises a head part and, downstream of the first mixer and upstream of the fluid outlet, a residence time arrangement fluidically connected to the head part for provision of a minimum residence time of the third stream, wherein the head part and the residence time arrangement are rigidly fastened to each other.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
77.
ULTRASONIC SENSOR SYSTEMS FOR CHARACTERIZING PARTICLE SUSPENSIONS
Systems and methods for characterizing a plurality of particles suspended in a solution are described. In some embodiments, an ultrasonic interrogation signal may be emitted into a solution including a plurality of particles suspended in the solution. A resulting ultrasonic spectrum may be sensed and provided to a trained statistical model of the solution. The trained statistical model may then determine one or more properties of the plurality of particles.
G01N 29/036 - Analyse de fluides en mesurant la fréquence ou la résonance des ondes acoustiques
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 29/34 - Génération des ondes ultrasonores, sonores ou infrasonores
G01N 29/44 - Traitement du signal de réponse détecté
G01N 29/46 - Traitement du signal de réponse détecté par analyse spectrale, p. ex. par analyse de Fourier
A method for operating a bioprocess installation with an electronic process control and at least one bioprocess unit, wherein the bioprocess unit comprises a cell broth source with a first receptacle for cell broth including cultivation media and cells, establishing a culture environment for cell cultivation and/or bio production, wherein the bioprocess unit comprises a clarification setup with a centrifuge for the clarification of the cell broth by centrifugation, with a liquid pumping arrangement assigned to the centrifuge and with a liquid network with a number of liquid lines communicating with the liquid pumping arrangement, wherein out of a first culture environment established by the first receptacle, the cell broth is transfered to the centrifuge via the liquid network, which centrifuge is operated in a forward operation for cell separation and/or cell washing and in a backward operation for cell discharging.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
The invention relates to a method for operating a continuous downstream process, in particular a continuous virus activation or inline dilution process, using a bio-process arrangement (1), wherein the bio-process arrangement (1) has a compensating container (2) with a first fluid inlet (3), configured for introduction of a concentrate stream, in particular a product or buffer concentrate stream, into the compensating container (2), with at least one second fluid inlet (4), configured for introduction of a diluent stream, in particular a product or buffer diluent stream, into the compensating container (2), with a fluid outlet (5), configured to discharge a liquid stream from the compensating container (2), wherein the bio-process arrangement (1) has a conveying arrangement (6) for fluid conveyance, which is allocated to the first fluid inlet (3) and to the second fluid inlet (4) for conveying in each case at least one liquid stream into the compensating container (2), and is allocated to the fluid outlet (5) for conveying a liquid stream out of the compensating container (2), and wherein the bio-process arrangement (1) has an electronic process control (7). It is proposed that the electronic process control (7) adapts, by controlling the conveying arrangement (6) in an open-loop and/or closed-loop manner, a fill level in the compensating container (2) such that a predefined minimum fill level in the compensating container (2) is always reached.
B01F 23/40 - Mélange de liquides avec des liquidesÉmulsion
B01F 35/83 - Formation d'un rapport prédéterminé des substances à mélanger en commandant le rapport entre plusieurs débits, p. ex. en utilisant des dispositifs de détection ou de commande du débit
B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Cartridges for filtering machines; filters for machines. Laboratory filters. Filters for industrial and household use (terms too vague in
the opinion of the International Bureau - Rule 13 (2) (b) of
the Common Regulations). filters for industrial
installations (terms too vague in the opinion of the
International Bureau - Rule 13 (2) (b) of the Common
Regulations).
filter cartridges for water purification;
filters for water filtering apparatus; water purification
filters; water treatment filters; water filters for
industrial purposes; industrial installations for filtering
liquids; water filtering apparatus; water filtering
installations; water filtering units; filters (not being
parts of machines) as components of filtration systems or as
independent filters for the sterilization and purification
of liquids and gases for the electronic, pharmaceutical,
food, luxury consumer goods and cosmetics industries in
general.
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Filter housings being parts of machines; filters being parts
of machines; filters for gases [machines]; filters for
machines; membrane filters for use as parts of machines. Filtering units for laboratory use; laboratory filters. Air filters; air filters for industrial use; air filters for
industrial installations; filters for cleaning and
sterilizing air; filters for gases [household or industrial
installations]; filters for cleaning and sterilizing gases
[parts of industrial installations]; filter elements for the
air vents of water supply tanks; filters for industrial and
household use (term considered too vague by the
International Bureau - Rule 13 (2) (b) of the Regulations);
filters for industrial installations (term considered too
vague by the International Bureau - Rule 13 (2) (b) of the
Regulations); filters for refrigeration systems; filters for
use with bioreactors and fermenters; filters for venting
storage tanks; industrial air filter machines; air filter
installations; filters, in particular filter cartridges and
membrane filters for single use as parts of filter systems
or as stand-alone filters for the sterilization and
purification of liquids and gases in the electronics,
pharmaceutical, food, beverage, luxury goods, cosmetics and
general chemical industries.
82.
METHOD FOR PERFORMING AN INTEGRITY TEST ON A TESTING CONSUMABLE OF A BIOPROCESS INSTALLATION
The invention relates to a method for performing an integrity test on a testing consumable (1) of a bioprocess installation using a test arrangement (2), wherein during a test routine (26), which is being performed by a test control unit (3) of the test arrangement (2), a predetermined test procedure is being applied to the testing consumable (1) via the test arrangement (2) and an integrity state is being derived from process data that have been collected during the test routine (26). It is proposed that during the test routine (26), early process data (27), that are being generated by a testing sensor arrangement (4) of the test arrangement (2) in an early stage of the test procedure, are being used to determine the integrity state of the testing consumable (1) by correlating in a correlating step (28) the early process data (27) to a system model (29) of a reference module (30), which reference module (30) emulates a, in particular integral, testing consumable (1) only in view of predetermined process data.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
B01D 65/10 - Test de membranes ou d'appareils à membranesDétection ou réparation de fuites
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
G01M 3/22 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour tuyaux, câbles ou tubesExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour raccords ou étanchéité de tuyauxExamen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs pour soupapes
G01N 15/08 - Recherche de la perméabilité, du volume des pores ou de l'aire superficielle des matériaux poreux
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Laboratory filters; Filtration membranes for laboratory use; Laboratory filtration apparatus and filtering materials for the filtration of liquids and gases; Filters, for use in relation to the following goods: Laboratory apparatus in the biopharmaceutical industry; Filtration units, For laboratory use. Filters, For industrial purposes; Filtration units; Filtration units, namely Filter cartridges, Filter capsules, Filter modules, Filter capsules and Disposable filters, For industrial purposes; Filters, namely Small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; Filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries.
84.
HOLDING DEVICE FOR A CONTAINER, HAVING A MAGNETIC DRIVE FOR A SEPARATE AGITATOR SHAFT
The invention relates to a holding device (26) for a container, in particular a bioreactor, comprising a magnetic drive (30) for a separate agitator shaft (28) and a lever device (10) for releasing the agitator shaft (28) from the magnetic drive (30). The magnetic drive (30) has a first coupling side (32) and the agitator shaft (28) has a second coupling side (34) of a magnetic coupling, said second coupling side being connectable to the first coupling side (32). The lever device (10) has at least one pressure portion (22; 64) and is pivotable between a closing position and a release position. As the lever device (10) is pivoted into the release position, the pressure portion (22; 64) is moved downwards in order to act directly or indirectly on the agitator shaft (28).
B01F 33/453 - Mélangeurs magnétiquesMélangeurs avec agitateurs à entraînement magnétique en utilisant des éléments d'agitation supportés ou suspendus
B01F 27/213 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins caractérisés par leurs arbres de rotation caractérisés par la liaison avec l'entraînement
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
Produits et services
Laboratory filters; Filtration membranes for laboratory use; Filters, for use in relation to the following goods: Laboratory apparatus in the biopharmaceutical industry; Filtration units, For laboratory use; Breather filters, For laboratory use. Filters, For industrial purposes; Filtration units, namely Filter cartridges, Filter capsules and Disposable filters, For industrial purposes; Filters, namely Small filters, disposable filters, filter cartridges, filter modules and diaphragm filters being parts of filtering units or being independent filters, for sterilisation and purification of liquids and gases in the beverage, food and general chemical industry; Filters, specifically filter cartridges and membrane filters for single use as parts of filter systems or as stand-alone filters for the sterilization and purification of liquids and gases in the electronics, pharmaceutical, food, beverage, luxury food, cosmetics and general chemical industries; Air filters; Air filters for industrial use; Air filters for industrial installations; Gas filters (industrial installations); Industrial air filter machines; Air filtering installations; Filters for purifying gaseous media and sterile ventilation of closed containers, conduits and tube systems; Filters for cleaning and sterilizing air; Parts of industrial installations, namely Filters for cleaning and sterilizing gases; Filters, for use in relation to the following goods: Transport container; Filters, for use in relation to the following goods: Containers, of plastic; Container attachment filters; Ventilation filters, For industrial purposes; Filters for the sterile gas exchange of containers; Filter elements for the air vents of water supply tanks; Filters for venting storage tanks; Filters for refrigeration systems; Filters, for use in relation to the following goods: Bio-reactors and Fermenters.
86.
METHOD OF CHANGING CULTURE MEDIUM OF A CULTURE USING SPINFILTERS
The present invention relates to a method of expanding stem cells cultured as cell aggregates in a suspension culture changing culture medium and a method of medium exchange for the same cells characterized in the use of a rotating mesh such as a spinfilter device. The present invention further relates to a use of a rotating mesh for medium exchange in a suspension culture of stem cells.
The invention relates to a method for operating a bioprocess installation (1) for production of a bioproduct, wherein the bioprocess installation (1) comprises a source receptacle (2) for cell cultivation, a harvest receptacle (3) for bioproduction and a clarification setup (4) with a centrifuge (12), wherein the source receptacle (2) is operated in a cyclical production mode comprising the steps of: a) starting the cyclical production mode in the source receptacle (2) b) cultivating the cells in the source receptacle (2), thereby obtaining a cell broth (7) comprising cultivated cells, c) discharging a discharge fraction (16) of the cell broth (7) from the source receptacle (2), d) combining a restart fraction (17) of the cell broth (7) with fresh cultivation medium (8) and repeating step b), e) repeating steps c) and d) at least once and/or f) discharging the cell broth (7) obtained from step d) from the source receptacle (2) stopping the cyclical production mode, obtaining a discharge fraction (16), wherein the method further comprises the steps of: i) centrifuging the discharge fraction (16) via the centrifuge (12), thereby separating the discharge fraction (16) into at least a centrifuged discharge fraction (19) and supernatant (14) and preferably bioproduct, ii) operating the harvest receptacle (3) in a production mode, wherein steps i) and ii) are executed at least twice.
C12M 1/107 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens pour recueillir les gaz de fermentation, p. ex. le méthane
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
17 - Produits en caoutchouc ou en matières plastiques; matières à calfeutrer et à isoler
Produits et services
Filter modules, namely filter capsules, filter candles, filter cassettes, coil modules, filter coils, filter coils in connection with filter centrifuges, band filters, small filters, small filters in connection with centrifuge tubes and as centrifugal concentrators, disposable filters; membrane filters and filter matting being parts of machines, for use in biotechnology, environmental protection, for the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and for use in genetic engineering, medicine and in laboratories, and for treatment and analysis of water and effluent; filters being parts of machines; membrane filters for use as part of machines. Laboratory filters; Filtering units for laboratory use; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors sold as a set for laboratory use; membranes for filtration [scientific]; filters for use with laboratory chromatography apparatus; membrane filters and filter matting with adsorption properties, membrane adsorbers, namely adsorption membranes, ion exchange membranes, ligand membranes and activated membranes in the form of hollow fibre membranes, tube membranes and flat membranes as strips or cut to size for use in apparatus, filters and filter modules for the aforesaid fields of application; membrane filters and filter matting as parts of microtitre plates; membrane filters and filter matting as parts of diagnostic tests such as diagnostic assays and immunoassays; membrane filters and filter matting as parts of filter systems or as independent filters for chromatographic analyses and chemical separation, reconcentration, for sterilisation and ultrapurification of fluids; filters and filter modules for filtering and reconcentration of biological solutions, namely of viral and bacterial suspensions; filters and filter modules for treating blood and other bodily fluids. Filters and filtering units, for industrial use; filters for filtering fluids, filter modules, filter candles and filter capsules; liquid filter units, namely, filter cartridges, plastic hoses and hose connectors, sold as a set, for industrial installations; Filters for water filtering apparatus; Cartridge filtration units [water treatment equipment]; filters for use with industrial chromatography apparatus; apparatus for water treatment and for preparing solutions in the pharmaceutical, medical and laboratory fields; equipment for de-ionising water; equipment for de-pyrogenisation of solutions and for separating harmful substances from fluids; filters and filter modules for desalination of protein solutions and other biological media; filters and filter modules for analysis and separation of ions, macromolecules and biomolecules, namely carbohydrates, peptides, proteins and nucleic acids and for separating heavy metals and harmful substances from fluids; filters for industrial use, namely, membrane filters and filter matting having applications in biotechnology, environmental protection, the drinks, food, luxury items, pharmaceutical, cosmetics, electronics and general chemical industries, and in genetic engineering, medicine and laboratories, and the treatment and analysis of water and effluents. Membranes and semi-processed synthetic filtering materials; Polymeric membranes; Polymeric porous membranes in hollow fibre form; Polymeric porous membranes in sheet form; Transfer membranes of cellulose derivatives; Transfer membranes of cellulose; Transfer membranes of polyamides; Transfer membranes of polyvinylidene fluoride; Cross-linked polymeric membranes in sheet form; Cross-linked polymeric membranes in hollow fibre form.
The invention relates to a method for a dynamic in-line mixing process of a pressurized medium (1), which contains a liquid and at least one additional liquid or solid constituent, in a bioprocess assembly (3). The liquid is combined with the at least one additional liquid or solid constituent in a specified volume ratio at an opening point (4) in order to form a resulting liquid flow (5), wherein the bioprocess assembly (3) has a pump assembly (8) with a first pump (9), the first pump (9) is arranged in the line (7) of the line assembly (6), the first pump (9) is designed as a rotary pump (10), in particular a centrifugal pump, which is designed for a dynamic in-line mixing process of the medium (1), the first pump (9) has a liquid inlet (9a) which forms the suction side of the pump when operated as intended and a liquid outlet (9b) which forms the pressure side of the pump when operated as intended, and the medium (1) is conducted through the rotary pump (10) for a dynamic in-line mixing process. According to the invention, the medium flows through the rotary pump (10) in the opposite flow direction, in comparison to the intended operation, for the dynamic in-line mixing process.
A device assembly for controlling an integrated continuous pharmaceutical or biopharmaceutical manufacturing process including a first process equipment for performing a first process step; a second process equipment for performing a second process step subsequent to the first process step; a single measuring unit for measurement of a set of signals of a liquid process medium at a single location, the measured signals depending on first and second parameters; and an evaluation and control unit for evaluating the measured signals to determine values of the first and second parameters. The evaluation and control unit determines first and second corrective feedback based on the values of the first and second parameters, respectively. The evaluation and control unit controls the first process step by providing the first corrective feedback to the first process equipment and controls the second process step by providing the second corrective feedback to the second process equipment.
Disclosed is inter alia a method for validating a filter unit, wherein the method comprises: - guiding a fluid flow of a fluid, after the fluid flow passed through the filter unit, to a measurement area that is connected to the filter unit, wherein within the measurement area the fluid is exposed to at least one alternating electric field between at least two electrodes; - obtaining at least one electric signal between the at least two electrodes, wherein the at least one electric signal is at least affected by whether one or more cells of a plurality of cells in the fluid pass through the measurement area; and - determining, at least partially based on the obtained at least one electric signal, at least one validity information indicating a validity of the filter unit.
A bioreactor system (10) for carrying out a biological process comprises a container (12) for receiving a liquid biological medium and a gas supply facility for feeding various gases from gas sources (38, 40, 42, 44) into the container (12) in a controlled manner. The gas supply facility has a plurality of gas outlet lines (28, 30, 32) which open into one or more gas supply devices (20) and/or into an overlay gas outlet in the interior of the container (12). Each gas outlet line (28, 30, 32) is connected to multiple gas sources (38, 40, 42, 44) by a respective gas supply line (46, 52, 56, 58) or by a respective branch (48, 50, 54, 60) of a gas supply line (46, 52, 56, 58). A mass flow regulator (62), which is connected to a control unit, is arranged in each gas supply line (46, 52, 56, 58) and in each branch (48, 50, 54, 60). Such a bioreactor system for carrying out a biological process preferably comprises a controller, which comprises a master regulator for a controlled variable, at least one sensor associated with the master regulator and one or more follower regulators with actuators (14, 62), the manipulated variables of which influence the controlled variable in a targeted manner. The controller is designed such that a setpoint value for the controlled variable can be prespecified to the master regulator, the at least one sensor is used for repeated determination of an actual value of the controlled variable, and the master regulator provides to the follower regulators an output signal dependent upon the deviation of the actual value of the controlled variable from the setpoint value of the controlled variable. Control profiles, which are dependent upon the output signal of the master regulator, are assigned to the follower regulators. According to a first alternative, the control profiles contain setpoint values for the actuators (14, 62) of the follower regulators, and the controller is designed such that the setpoint values for the actuators (14, 62) can be input in the physical unit of their manipulated values. According to a second alternative, the control profiles contain setpoint values for a parameter that relates directly to the biological process and can be influenced in a targeted manner by the actuators (14, 62), and the controller is designed such that it automatically assigns setpoint values for the actuators of the follower regulators to the parameter setpoint values.
The invention relates to a flow-through centrifuge (1), which can be used for example for biotechnological applications, in particular in the form of a blood centrifuge (2). A drive and/or transmission assembly (19) of the through-flow centrifuge (1) has a planetary transmission (62). At least one planetary belt pulley (34; 36) is rotatably mounted on a rotating planet carrier (18) in the planetary transmission (62), and the torque of the planetary belt pulley (34; 36) is transmitted via a belt (33; 37), wherein the planet carrier (18) and the belt pulley (34; 36) are driven at different rotational speeds. According to the invention, the planet carrier (18) is held via a belt-tensioning unit (17) which rotates together with the planet carrier (18), and the distance (42) between the planet carrier (18) and a rotor axis (4) can be modified via the belt-tensioning unit (17) in order to set the tension of the belt (33; 37).
A method for mounting at least one component on an installation includes attaching a carrier directly or indirectly to the installation, where the installation has at least one frame with at least two arms, at least one base plate, and at least one deformable element. The method further includes displacing the component toward the deformable element such that the deformable element is displaced from a receiving state (AUZ), in which the deformable element is ready to receive the component of the installation, toward a locked state (ARZ), as a result of which the deformable element surrounds and mounts the component of the installation at least in part.
A method for providing an integrity test of a double filter capsule can include providing the double filter capsule in such a way that in a filtration process the medium to be filtered flows in its flow direction from an upstream chamber in the housing through a first filter into an intermediate chamber between the first filter and a second filter and then through the second filter to an outlet. The housing can have an upstream-chamber access point for feeding a test fluid into the upstream chamber and an intermediate-chamber access point for feeding the test fluid into the intermediate chamber. Additional steps can include providing a connecting line between the upstream-chamber access point and the intermediate-chamber access point and determining the state of integrity of the double filter capsule on the basis of at least two test phases.
B01D 65/10 - Test de membranes ou d'appareils à membranesDétection ou réparation de fuites
B01D 29/11 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants avec des éléments filtrants en forme de sac, de cage, de tuyau, de tube, de manchon ou analogue
B01D 29/56 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants à plusieurs éléments filtrants caractérisés par leur agencement relatif montés en série
96.
CHROMATOGRAPHIC MATERIAL AND METHOD OF PRODUCING SAME
The present invention relates to a chromatographic material comprising a polymer network material-based self-supporting bi-continuous separation matrix for adsorptive material separation in liquid media, and a method of producing the chromatographic material comprising a polymer network material-based self-supporting bi-continuous separation matrix.
B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 20/285 - Absorbants ou adsorbants poreux à base de polymères
The invention is directed to a method for producing a roll (1) or sheet of membrane units (2) for a membrane product (3) such as a lateral flow test from a roll (6) or sheet of membrane material (7), by means of a primary production arrangement (9), wherein the roll (6) or sheet of membrane material (7) is processed into a roll (1) or sheet of membrane units (2) in a primary processing routine, wherein in the primary processing routine, for generating the membrane units (2), a fluidic structure (11), in particular a hydrophobic structure, for defining fluid flow through the membrane material (7) is introduced into the membrane material (7) by means of a processing tool (12), wherein an evaluation routine is performed by means of an evaluation arrangement (15) comprising a sensor arrangement (16) and an evaluation control (17). It is proposed that in the evaluation routine, evaluation images (18) of the fluidic structures (11) of the membrane units (2) are generated by means of the sensor arrangement (16) and evaluation data (19) are generated by means of the evaluation control (17) and that the evaluation data (19) represent the deviation in predefined geometrical properties of the fluidic structure (11) in the respective evaluation image (18) with respect to the fluidic structure (11) in a reference image (21).
The present invention relates to automated nanoparticle synthesis systems and computer-implemented methods of monitoring and controlling a process of manufacturing lipid nanoparticles (LNPs) containing nucleic acid cargo. The present invention furthermore relates to a computer program product comprising computer-readable instructions, which, when loaded and executed on a computer system, causes the computer system to perform operations according to said methods.
A method for ensuring a microbiological purity of a single-use device for carrying out a biotechnological process, the single-use device including at least one gamma-sterilizable component which is formed from materials suitable for a sterilization by gamma radiation, and at least one non-gamma-sterilizable subunit which contains a material unsuitable for a sterilization by gamma radiation. Both the component and the subunit each have an area that comes into contact with a process medium when the biotechnological process is carried out. The method includes the steps of sterilizing the gamma-sterilizable component by gamma radiation; protecting the medium-contacting area of the gamma-sterilizable component by a sterile barrier; sterilizing the non-gamma-sterilizable subunit with superheated steam; protecting the medium-contacting area of the non-gamma-sterilizable subunit by a sterile barrier; removing the sterile barriers; and mounting the gamma-sterilized component and the superheated steam-sterilized subunit in the single-use device immediately after removing the sterile barriers.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
A61L 2/07 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques de la chaleur des gaz chauds de la vapeur
100.
CENTRIFUGE, METHOD FOR OPERATING A CENTRIFUGE AND COMPUTER-READABLE MEDIUM
The invention relates to a centrifuge (19), in particular a continuous-flow centrifuge, a biotechnical centrifuge or a blood centrifuge. The centrifuge (19) is provided with a coolant circuit (1). According to the invention, the outlet side of a controllable compressor (4) is connected to an inlet side of an evaporator (2) via a bypass line (5) with a valve (20) arranged therein. In a normal operating mode, when the valve (20) is closed, the cooling of a centrifuge bowl (3) occurs exclusively via the control of the compressor (4) and an expansion unit (6). However, if the target temperature in the centrifuge bowl (3) falls below a tolerance range, the valve (20) is opened in order to bring about a heating process and thereby a returning of the temperature in the centrifuge bowl (3) to within the tolerance range.
