The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application further provides novel methods of developing stable peptide-based capture agents, including Akt capture agents, using iterative on-bead in situ click chemistry.
C07K 7/02 - Peptides linéaires contenant au moins une liaison peptidique anormale
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
C12Q 1/6804 - Analyse d’acides nucléiques utilisant des immunogènes
G01N 33/573 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour enzymes ou isoenzymes
2.
SUPER-RESOLVED OBJECT DETECTION WITH SPATIAL GENOMICS
The present disclosure provides methods for encoding and decoding signals from barcodes in a plurality of molecular targets from images obtained from imaging based spatial genomics (ISG) experiments. This disclosure sets forth methods, in addition to use of the same, and other solutions to problems in the relevant field.
G06K 19/06 - Supports d'enregistrement pour utilisation avec des machines et avec au moins une partie prévue pour supporter des marques numériques caractérisés par le genre de marque numérique, p. ex. forme, nature, code
The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci.
Laser speckle contrast imaging techniques that apply a temporal sliding window to a sequence of speckle frames of an avian egg to determine overlapping sets of speckle frames used to reconstruct a sequence of extraembryonic blood vessel images (e.g., movie) showing blood flow dynamics, and where input to a machine learning model based on the overlapping sets of speckle frames can be used to predict the developmental stage of the avian egg, and where the overlapping sets of speckle frames can be used in drug screening.
A device including an optical aperture comprising a plurality of outwardly facing modulating retroreflectors (MRR) disposed at a same radius about a center point; wherein each of the MRRs comprises a plurality of reflectors coupled to a modulator. A number and arrangement of the reflectors is configured to enable positioning of the aperture from a ranging measurement of a coordinate of the modulator using retroreflections of laser beams back to at least one base station after transmission from the at least one base station and when the aperture is attached to an airborne or spaceborne unmanned vehicle.
H04B 10/112 - Transmission dans la ligne de visée sur une distance étendue
G02B 5/124 - Réflecteurs reflex du type en sommet de cube, en trièdre ou en réflecteur triple plusieurs éléments réfléchissants faisant partie d'une plaque ou d'une feuille formant un tout
Disclosed herein include methods, compositions, and kits suitable for use in integration of a nucleic acid sequence into a double-stranded target sequence of a genome of a plant cell or a target plasmid in a plant cell. In some embodiments, the methods, systems and nucleic acid compositions comprise polynucleotides encoding and RNA-guided DNA binding complex, a transposition complex, for insertion of cargo sequence using transposition.
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
7.
Targeted DNA Integration in Plants by CRISPR-Associated Transposases (CASTs)
Disclosed herein include methods, compositions, and kits suitable for use in integration of a nucleic acid sequence into a double-stranded target sequence of a genome of a plant cell or a target plasmid in a plant cell. In some embodiments, the methods, systems and nucleic acid compositions comprise polynucleotides encoding and RNA-guided DNA binding complex, a transposition complex, for insertion of cargo sequence using transposition.
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
Aspects disclosed herein include a composite material comprising: one or more shape memory polymers; and a first additive provided in the shape memory polymer(s); wherein: the first additive increases one or more ultrasound-absorption characteristics of the composite material compared to that of the same shape memory polymer(s) free of said first additive; the composite material is characterized by a composite transition temperature (Tcm,trans); and the composite material or one or more portions thereof undergo a shape change from a temporary shape to a permanent shape when the composite material or said one or more portions thereof are heated to within 35° C. of Tcm,trans or a temperature approximately equal to or greater than Tcm,trans.
B29C 61/06 - Fabrication de préformes ayant des contraintes internes, p. ex. mémoire plastique
A61L 31/12 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
B29K 105/00 - Présentation, forme ou état de la matière moulée
B29K 105/24 - Présentation, forme ou état de la matière moulée réticulée ou vulcanisée
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (USA)
Inventeur(s)
Zhou, Hengyun
Ataides, Juan Pablo, Bonilla
Bluvstein, Dolev
Wurtz, Jonathan
Lukin, Mikhail, D.
Xu, Qian
Jiang, Liang
Pattison, Christopher, A.
Raveendran, Nithin
Vasic, Bane
Abrégé
Quantum error correction in reconfigurable atom arrays is described. A plurality of data qubits is provided, each of the plurality of data qubits disposed in a corresponding trap. A plurality of ancilla qubits is provided, each of the plurality of ancilla qubits disposed in a corresponding trap. The plurality of data qubits and the plurality of ancilla qubits are arranged in a plurality of rows and a plurality of columns, thereby forming a lattice. A plurality of permutations of the plurality of rows and the plurality of columns is performed, each of the plurality of permutations placing each of the plurality of data qubits within an interaction radius of one of the plurality of ancilla qubits, thereby forming a plurality of proximate pairs. Subsequent to each of the plurality of permutations, a global control pulse is applied to the lattice, thereby applying a gate to each of the plurality of proximate pairs, and thereby encoding a parity check matrix between the plurality of ancilla qubits and the plurality of data qubits.
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
CALIFORNIA INSTITUTE OF TECHNOLOGY (USA)
THE UNIVERSITY OF CHICAGO (USA)
Inventeur(s)
Zhou, Hengyun
Ataides, Juan, Pablo, Bonilla
Bluvstein, Dolev
Wurtz, Jonathan
Lukin, Mikhail, D.
Xu, Qian
Jiang, Liang
Pattison, Christopher, A.
Raveendran, Nithin
Vasic, Bane
Abrégé
Constant-overhead fault-tolerant quantum computation is provided. A first plurality of physical qubits is configured to encode a first plurality of logical qubits using a quantum low-density parity-check (qLDPC) code. A second plurality of physical qubits is configured to encode a second plurality of logical qubits using an error-correcting code; and a plurality of ancilla qubits. The quantum computing system is configured to teleport at least one of the first plurality of logical qubits into a corresponding at least one of the second plurality of logical qubits via the plurality of ancilla qubits. The quantum computing system is configured to perform at least one logical operation on the at least one of the second plurality of logical qubits. The quantum computing system is configured to teleport the at least one of the second plurality of logical qubits into the at least one of the first plurality of qubits via the plurality of ancilla qubits.
G06N 10/00 - Informatique quantique, c.-à-d. traitement de l’information fondé sur des phénomènes de mécanique quantique
11.
TIMED AND/OR TARGETED CHLORATE ADMINISTRATION, AND RELATED MATRICES, COMPOSITIONS, IMPLANTS, METHODS AND SYSTEMS FOR PREVENTION AND/OR TREATMENT OF INFECTIONS
Methods and systems and related compositions, matrices and devices, for timed and/or targeted administration of chlorate for treatment and/or prevention of infections of a biological environment and related compositions, devices, matrices and implants. Chlorate administration can be performed alone or in combination with an antibiotic in a location and/or time targeted manner, the concentration and use of the chlorate and/or the antibiotic agents depending on the oxic/hypoxic/anoxic condition of the area being treated.
A61K 33/00 - Préparations médicinales contenant des ingrédients actifs inorganiques
A01N 59/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des éléments ou des composés inorganiques
A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61F 13/00 - Bandages ou pansementsGarnitures absorbantes
A61L 26/00 - Aspects chimiques des bandages liquides ou utilisation de matériaux pour les bandages liquides
Provided are separator systems for electrochemical systems providing electronic, mechanical and chemical properties useful for a variety of applications including electrochemical storage and conversion. Embodiments provide structural, physical and electrostatic attributes useful for managing and controlling dendrite formation and for improving the cycle life and rate capability of electrochemical cells including silicon anode based batteries, air cathode based batteries, redox flow batteries, solid electrolyte based systems, fuel cells, flow batteries and semisolid batteries. Disclosed separators include multilayer, porous geometries supporting excellent ion transport properties, providing a barrier to prevent dendrite initiated mechanical failure, shorting or thermal runaway, or providing improved electrode conductivity and improved electric field uniformity. Disclosed separators include composite solid electrolytes with supporting mesh or fiber systems providing solid electrolyte hardness and safety with supporting mesh or fiber toughness and long life required for thin solid electrolytes without fabrication pinholes or operationally created cracks.
H01M 50/449 - Séparateurs, membranes ou diaphragmes caractérisés par le matériau ayant une structure en couches
H01G 9/00 - Condensateurs électrolytiques, redresseurs électrolytiques, détecteurs électrolytiques, dispositifs de commutation électrolytiques, dispositifs électrolytiques photosensibles ou sensibles à la températureProcédés pour leur fabrication
H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif
H01M 4/131 - Électrodes à base d'oxydes ou d'hydroxydes mixtes, ou de mélanges d'oxydes ou d'hydroxydes, p. ex. LiCoOx
H01M 4/133 - Électrodes à base de matériau carboné, p. ex. composés d'intercalation du graphite ou CFx
H01M 4/134 - Électrodes à base de métaux, de Si ou d'alliages
H01M 4/136 - Électrodes à base de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFy
H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p. ex. LiNiO2, LiCoO2 ou LiCoOxFy
H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
H01M 4/587 - Matériau carboné, p. ex. composés au graphite d'intercalation ou CFx pour insérer ou intercaler des métaux légers
H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
H01M 8/02 - Éléments à combustibleLeur fabrication Détails
H01M 8/0245 - Composites sous forme de produits en couches ou enrobés
H01M 8/1016 - Éléments à combustible avec électrolytes solides caractérisés par le matériau d’électrolyte
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
H01M 10/0568 - Matériaux liquides caracterisés par les solutés
H01M 10/0569 - Matériaux liquides caracterisés par les solvants
H01M 10/0585 - Structure ou fabrication d'accumulateurs ayant uniquement des éléments de structure plats, c.-à-d. des électrodes positives plates, des électrodes négatives plates et des séparateurs plats
H01M 12/08 - Éléments hybridesLeur fabrication composés d'un demi-élément du type élément à combustible et d'un demi-élément du type à élément secondaire
H01M 50/403 - Procédés de fabrication des séparateurs, des membranes ou des diaphragmes
H01M 50/446 - Matériau composite constitué d’un mélange de matériaux organiques et inorganiques
H01M 50/457 - Séparateurs, membranes ou diaphragmes caractérisés par le matériau ayant une structure en couches comprenant au moins trois couches
H01M 50/463 - Séparateurs, membranes ou diaphragmes caractérisés par leur forme
H01M 50/489 - Séparateurs, membranes, diaphragmes ou éléments d’espacement dans les cellules caractérisés par leurs propriétés physiques, p. ex. degré de gonflement, hydrophilicité ou propriétés pour court-circuiter
A method and system provide the ability to compile computer code. Human readable text in a programming language is optimized in a compiler, into a processor specific language. The optimization includes determining a set of two or more optimization routines, randomly selecting a selected optimization routine from the set of two or more optimization routines, and applying the selected optimization routine to each segment of the human readable text. Binary code is then output based on the optimized human readable text and has improved resistance to subversion.
A measurement device includes: a processing device and multiple sensors that capture tomographic information of a physiological structure. The sensors include a first sensor including a first transducer having a first frequency response with a first resonant frequency, and a second sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits a signal that is reflected by the physiological structure to create a reflected signal, the first transducer generates a first received signal from the reflected signal, the second transducer generates a second received signal from the reflected signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.
Computational refocusing-assisted deep learning methods, apparatus, and systems are described. In certain pathology examples, a representative image is generated using a machine learning model trained with uniformly focused training images generated by a Fourier ptychographic digital refocusing procedure and abnormalities are automatedly identified and/or enumerated based on the representative image.
Methods and systems are described of a stochastic quantitative approach (StochQuant) that uses molecular counts obtained from a testing measurement, an absolute anchoring measurement of a reference molecule, and possibly additional physical parameters such as quantitatively measurable amounts of a sample, to identify a probability distribution, a confidence interval and/or a confidence level in outcome of a testing measurement of a target molecule, thus improving reliability and accuracy of quantitative detection of the target molecule performed by the testing measurement.
A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.
G01R 31/385 - Dispositions pour mesurer des variables des batteries ou des accumulateurs
G01R 19/165 - Indication de ce qu'un courant ou une tension est, soit supérieur ou inférieur à une valeur prédéterminée, soit à l'intérieur ou à l'extérieur d'une plage de valeurs prédéterminée
G01R 29/08 - Mesure des caractéristiques du champ électromagnétique
G01R 31/382 - Dispositions pour la surveillance de variables des batteries ou des accumulateurs, p. ex. état de charge
G01R 31/392 - Détermination du vieillissement ou de la dégradation de la batterie, p. ex. état de santé
G01R 31/50 - Test d’appareils, de lignes, de câbles ou de composants électriques pour y déceler la présence de courts-circuits, de continuité, de fuites de courant ou de connexions incorrectes de lignes
G01R 31/52 - Test pour déceler la présence de courts-circuits, de fuites de courant ou de défauts à la terre
H01G 11/14 - Agencements ou procédés de réglage ou de protection des condensateurs hybrides ou EDL
H01M 10/42 - Procédés ou dispositions pour assurer le fonctionnement ou l'entretien des éléments secondaires ou des demi-éléments secondaires
H01M 10/48 - Accumulateurs combinés à des dispositions pour mesurer, tester ou indiquer l'état des éléments, p. ex. le niveau ou la densité de l'électrolyte
18.
GAS VESICLE EXPRESSION SYSTEMS, GAS VESICLE CONSTRUCTS AND RELATED GENETIC CIRCUITS, VECTORS, MAMMALIAN CELLS, HOSTS, COMPOSITIONS, METHODS AND SYSTEMS
Provided herein are genetically engineered gas vesicle expression systems (GVES) that are configured to express gas vesicles (GVs) in a mammalian cell, related gas vesicle polynucleotide constructs, gas vesicle reporting genetic circuits, vectors, genetically engineered mammalian cells, non-human mammalian hosts, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging techniques to detect and report biological events in an imaging target site comprising a mammalian cell and/or organism.
Compounds able to affect production and/or activity of a redox active compound, which include candidate therapeutic compounds and candidate compounds for enhancing power output of a microbial fuel cell, and related compositions, methods and systems.
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
A61K 31/7052 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides
A61K 31/7056 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à cinq chaînons avec l'azote comme hétéro-atome d'un cycle
A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
20.
THIN FILM SYNCHRONOUSLY PUMPED OPTICAL PARAMETRIC OSCILLATORS
A device including a photonic integrated circuit comprising one or more OPOs each comprising: an input configured to receive a pump wave comprising pulses or a frequency comb with a pump repetition rate, one or a plurality of nonlinear sections as part of a resonator or coupled to a resonator having a free spectral range, where at least one of the free spectral range or one of its harmonics is matched to the pump repetition rate or its harmonics, and one or a plurality of outputs configured to extract a portion of the waves generated by the OPO in response to the pump wave and/or the pump wave.
The present invention uses tunable or broadband integrated OPO with active or passive beam steering devices for high-speed ranging on a compact, low-cost platform. Examples of beam steering devices include grating couplers, optical phased arrays, arrayed waveguide delay lines, nanophotonic antennas, metasurfaces, etc. The beam steering device can be inside or outside of the OPO structure. Under broadband operation, the angular information is encoded in the spectral domain and vice versa, and the detector may have multiple spectral filters corresponding to different angles or a single tunable filter. The tunable filter can be electro-optic (EO) based or piezoelectric (PZT)-based. This invention can be realized across multiple material platforms with application specific parameters to optimize performance, such as bandwidth, tuning range, tuning speed, spatial/temporal resolution, polarization, field of view (FOV), etc. Scanning can be done in 1D and 2D. Multiple OPOs can be fabricated on chip with multiple beam steering devices.
G01S 17/10 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes à modulation d'impulsion interrompues
G01S 17/34 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées utilisant la transmission d'ondes continues modulées en fréquence, tout en faisant un hétérodynage du signal reçu, ou d’un signal dérivé, avec un signal généré localement, associé au signal transmis simultanément
G02B 6/00 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage
G02B 6/12 - Guides de lumièreDétails de structure de dispositions comprenant des guides de lumière et d'autres éléments optiques, p. ex. des moyens de couplage du type guide d'ondes optiques du genre à circuit intégré
22.
BIPEDAL ROBOT WITH INTEGRATED THRUSTER-ASSISTED LOCOMOTION
A bipedal robot having a legged assembly and an aerial assembly is described. The legged assembly includes two legs, each leg having a hip frontal joint, a hip sagittal joint, and a knee joint. The aerial assembly includes two thrusters mounted on a carbon fiber-aluminum composite mount. Actuators for the joints include 3D printed housings with embedded components. A controller generates walking trajectories and controls the thrusters to assist with stabilization and obstacle traversal. The robot is capable of dynamic multimodal locomotion, combining legged movement with thruster-assisted stabilization and jumping to navigate challenging terrain.
B60F 5/02 - Autres véhicules capables de se déplacer dans ou sur des milieux différents convertibles en avion
B62D 57/032 - Véhicules caractérisés par des moyens de propulsion ou de prise avec le sol autres que les roues ou les chenilles, seuls ou en complément aux roues ou aux chenilles avec moyens de propulsion en prise avec le sol, p. ex. par jambes mécaniques avec une base de support et des jambes soulevées alternativement ou dans un ordre déterminéVéhicules caractérisés par des moyens de propulsion ou de prise avec le sol autres que les roues ou les chenilles, seuls ou en complément aux roues ou aux chenilles avec moyens de propulsion en prise avec le sol, p. ex. par jambes mécaniques avec des pieds ou des patins soulevés alternativement ou dans un ordre déterminé
B64C 25/50 - Atterrisseurs orientablesAmortissement du shimmy
B64C 25/58 - Aménagements ou adaptations des amortisseurs ou des ressorts
Systems and methods are provided for a wearable mask that analyzes exhaled breath condensate (EBC) for health monitoring. Specifically, the wearable mask is a smart mask designed to harvest and analyze EBC in real- or near-real-time, and provide insights into the wearer's respiratory and metabolic health. The smart mask incorporates tandem passive cooling technologies, automated microfluidics, selective electrochemical biosensing, and wireless communication within the mask's framework. This integration allows for non-invasive, continuous monitoring of various biomarkers present in the EBC across different environments, enabling personalized health surveillance during regular daily activities. The smart mask is capable of detecting a broad spectrum of biomarkers, including volatile organic compounds (VOCs), nitric oxide, cytokines, and pathogens indicative of respiratory conditions.
The present invention uses tunable or broadband integrated OPO with active or passive beam steering devices for high-speed ranging on a compact, low-cost platform. Examples of beam steering devices include grating couplers, optical phased arrays, arrayed waveguide delay lines, nanophotonic antennas, metasurfaces, etc. The beam steering device can be inside or outside of the OPO structure. Under broadband operation, the angular information is encoded in the spectral domain and vice versa, and the detector may have multiple spectral filters corresponding to different angles or a single tunable filter. The tunable filter can be electro-optic (EO) based or piezoelectric (PZT)-based. This invention can be realized across multiple material platforms with application specific parameters to optimize performance, such as bandwidth, tuning range, tuning speed, spatial/temporal resolution, polarization, field of view (FOV), etc. The scanning can be done in 1D and 2D. Multiple OPOs can be fabricated on the same chip along with multiple beam steering devices, to extend the wavelength tuning range and subsequent FOV in 1D and 2D scanning.
G02F 1/39 - Optique non linéaire pour la génération ou l'amplification paramétrique de la lumière, des infrarouges ou des ultraviolets
G02F 1/29 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de la position ou de la direction des rayons lumineux, c.-à-d. déflexion
H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
G01S 17/34 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes continues, soit modulées en amplitude, en fréquence ou en phase, soit non modulées utilisant la transmission d'ondes continues modulées en fréquence, tout en faisant un hétérodynage du signal reçu, ou d’un signal dérivé, avec un signal généré localement, associé au signal transmis simultanément
G01S 7/481 - Caractéristiques de structure, p. ex. agencements d'éléments optiques
25.
A SMART MASK FOR EXHALED BREATH CONDENSATE HARVESTING AND ANALYSIS
Systems and methods are provided for a wearable mask that analyzes exhaled breath condensate (EBC) for health monitoring. Specifically, the wearable mask is a smart mask designed to harvest and analyze EBC in real- or near-real-time, and provide insights into the wearer's respiratory and metabolic health. The smart mask incorporates tandem passive cooling technologies, automated microfluidics, selective electrochemical biosensing, and wireless communication within the mask's framework. This integration allows for non-invasive, continuous monitoring of various biomarkers present in the EBC across different environments, enabling personalized health surveillance during regular daily activities. The smart mask is capable of detecting a broad spectrum of biomarkers, including volatile organic compounds (VOCs), nitric oxide, cytokines, and pathogens indicative of respiratory conditions.
A system of a multi-rotor aircraft that capitalizes on the advantages of fixed wing elements combined with rotary wing structures. The fixed wing elements can help to generate lift once the aircraft is airborne and can thus reduce the need for larger lifting rotors which can allow for longer flight times and distances. Additionally, the systems disclosed herein take advantage of a partial in-wing configuration with a number of rotors to reduce the overall footprint of the vehicle while maintaining the flight efficiency that comes with combining features of fixed and rotary wing elements, and increasing operator safety by shrouding rotating parts. The unique configurations allow for a decoupling of the pitch, yaw and roll authority to reduce the complexity in control systems and improve the flight efficiency of the aircraft. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque.
B64C 13/20 - Dispositifs amorçant la mise en œuvre actionnés automatiquement, p. ex. répondant aux détecteurs de rafales utilisant des émissions de signaux
B64C 11/46 - Aménagements ou caractéristiques de construction des hélices multiples
B64C 29/00 - Aéronefs capables d'atterrir ou de décoller à la verticale, p. ex. aéronefs à décollage et atterrissage verticaux [ADAV, en anglais VTOL]
B64C 39/08 - Aéronefs non prévus ailleurs à ailes multiples
B64U 10/20 - Aéronefs à décollage et atterrissage verticaux [ADAV, en anglais VTOL]
Described herein are systems for determining an absence, or presence and size of particles in a liquid pharmaceutical product. The systems may comprise a Mie-scattering-based light sheet (MSLS) liquid particle analyzer. Described herein are method for determining an absence, or presence and size of particles in a liquid pharmaceutical product.
G01N 15/0205 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques
G01N 15/075 - Recherche de la concentration des suspensions de particules par des moyens optiques
G01N 21/01 - Dispositions ou appareils pour faciliter la recherche optique
G01N 21/51 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide à l'intérieur d'un récipient, p. ex. dans une ampoule
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
A high-power density electric propulsion (EP) system is presented. High-power density functionality of the EP system is provided via thermal management structures that separately manage heat from a discharge chamber with electrically conductive inner/outer walls and an electromagnetic circuit of the EP system. The thermal management structures include separate radiators for rejection of heat from the discharge chamber and the electromagnetic circuit, the heat coupled to the radiators via respective thermal shunts. The thermal shunts include radially inwardly and/or outwardly projecting heat conducting structures that are thermally coupled to the discharge chamber and the electromagnetic circuit. Openings formed in annular structures of the electromagnetic circuit allow radial projection of the thermal shunts.
Nonlinear ultrasound imaging techniques that send ultrasound transmissions with multiple frequency or phase cycles for exciting and imaging nonlinear scatterers such as acoustic biomolecules. an ultrasound imaging system includes an arrangement of transducer elements (e.g., an ultrasound probe) and a plurality of apertures of different sets of transducer elements in the arrangement of transducer elements. Each transducer element of each aperture is configured to generate an acoustic wave when activated by a transmission signal having a plurality of cycles. The acoustic waves generated by each set of transducer elements of each aperture form an acoustic beam along an axis.
Some aspects of the present disclosure relate to methods and devices for identifying soil bacteria-enriching agents that selectively enrich a desired species of bacteria in a soil microbiome. In some embodiments, the soil bacteria-enriching agent comprises a carbon substrate and/or a chemoeffector. Some aspects of the present disclosure relate to methods of enriching a desired species of bacteria in a soil microbiome using one or more soil bacteria-enriching agents.
Nonlinear ultrasound imaging techniques that send ultrasound transmissions with multiple frequency or phase cycles for exciting and imaging nonlinear scatterers such as acoustic biomolecules.
An entertainment system generates a tone mark in response to a tone mark generating operation performed by a first player, move the tone mark toward a second player area, generates a tone mark in response to a tone mark generating operation performed by a second player, and moves the tone mark toward a first player area. When the tone mark generated by the second player arrives at the first player area, whether the first player performs a tone output operation is determined. When the tone mark generated by the first player arrives at the second player area, whether the second player performs a tone output operation is determined. Communication points are calculated based on the tone mark generating operation and the tone output operation by the first player and the tone mark generating operation and the tone output operation by the second player.
Disclosed herein include method and systems suitable for use in detection and/or prediction of microorganisms in a sample using sequencing data. In some embodiments, the method comprises converting reference sequences and sample sequences to comma-free sample codes; and detecting the presence of microbes in the sample based on alignment of the comma-free codes. In some embodiments, the method comprises detecting and/or predicting viral presence in host cell, by identifying and analyzing signature host genes. In some embodiments, the system suitable for performing the methods disclosed herein.
G16B 30/10 - Alignement de séquenceRecherche d’homologie
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
Disclosed herein include method and systems suitable for use in detection and/or prediction of microorganisms in a sample using sequencing data. In some embodiments, the method comprises converting reference sequences and sample sequences to comma-free sample codes; and detecting the presence of microbes in the sample based on alignment of the comma-free codes. In some embodiments, the method comprises detecting and/or predicting viral presence in host cell, by identifying and analyzing signature host genes. In some embodiments, the system suitable for performing the methods disclosed herein.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms showing increased specificity and efficiency of viral transduction in targeted cell-types, for e.g., the brain, and lung. The rAAV compositions described herein also have tropisms showing decreased specificity and decreased efficiency of viral transduction in an off-target cell type, for e.g., the liver. The rAAV compositions described herein encapsidate a transgene, such a therapeutic nucleic acid. Upon systemic delivery to a subject, the rAAV is capable of increased specificity and increased transduction of the transgene in a target cell-type, as compared to a parental or reference AAV.
A device useful as a spectrometer or a sensor, comprising a source of a short electromagnetic pulses at a first wavelength and having a full width at half maximum in a range of 1 femtosecond-1 nanosecond; a sample holder in which the short pulses interact with the sample in the sample holder so as to form an output signal comprising a background residual of the short pulses and a sample response signal in the time domain, and an amplifier comprising nonlinear medium. The nonlinear medium comprises an input for receiving the output signal and a pump pulse at a second wavelength, and a second-order nonlinearity configured for a nonlinear process selectively amplifying the sample response signal, for example by temporally overlapping the pump pulse and the sample response signal.
G02F 1/355 - Optique non linéaire caractérisée par les matériaux utilisés
H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
38.
SYSTEMS, DEVICES, AND METHODS RELATING TO THE MANUFACTURE OF IMPLANTABLE PROSTHETIC VALVES
Improved prosthetic valves, their methods of manufacture, and systems and devices for manufacturing the valves are described. The prosthetic valves can be configured for transcatheter implantation. The prosthetic valves can have artificial leaflets. The prosthetic valves can be manufactured in numerous ways, such as by polymeric dipping processes and/or electrospinning. Sponge-like polymers for valves and other medical devices are also disclosed.
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
C07H 15/04 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'oxygène d'un radical saccharide
A01N 37/36 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant au moins un groupe carboxylique ou un thio-analogue, ou d'un de leurs dérivés, et un atome d'oxygène ou de soufre lié par une liaison simple, liés au même squelette carboné, cet atome d'oxygène ou de soufre ne faisant pas partie d'un groupe carboxylique ou d'un thio-analogue, ou d'une de leurs dérivés, p. ex. acides hydroxycarboxyliques
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
A01N 43/38 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à cinq chaînons condensés avec des carbocycles
A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
A61K 31/7028 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques
C07H 15/10 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'oxygène d'un radical saccharide contenant des liaisons non saturées carbone-carbone
C07H 15/18 - Radicaux acycliques substitués par des carbocycles
C07H 15/26 - Radicaux acycliques ou carbocycliques substitués par des hétérocycles
40.
ULTRASENSITIVE MOLECULAR DETECTION VIA HYBRIDIZATION CHAIN REACTION
The present application relates to hybridization chain reaction (HCR). In particular, compositions and methods are presented for ultrasensitive molecular detection using HCR signal amplification. Some embodiments and methods involve cooperative probe junctions, reporter-labeled probes, and nonlinear HCR signal amplification.
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
ELECTRON-DEFICIENT PHOSPHINE-PHOSPHONIUM-PHENOL SUPPORTED NICKEL(II) AND PALLADIUM(II) CATALYSTS FOR THE COPOLYMERIZATION OF ETHYLENE AND ACRYLATE COMONOMERS
Processes of polymerizing olefin monomers, including polar comonomers, using catalyst systems and catalysts systems that include a procatalyst having a structure according to formula (I).
C08F 220/18 - Esters des alcools ou des phénols monohydriques des phénols ou des alcools contenant plusieurs atomes de carbone avec l'acide acrylique ou l'acide méthacrylique
C08F 4/80 - MétauxHydrures métalliquesComposés organiques de métalLeur utilisation comme précurseurs de catalyseurs choisis parmi les métaux non prévus dans le groupe choisis parmi les métaux du groupe du fer ou les métaux du groupe du platine
42.
SYSTEMS AND METHODS FOR CO-DISCOVERING GRAPHICAL STRUCTURE AND FUNCTIONAL RELATIONSHIPS WITHIN DATA
Systems and methods for hypergraph discovery in accordance with embodiments of the invention include a method of processing input data, comprising receiving input data at a data processing system, providing the input data to a discovered hypergraph, and generating an output using the discovered hypergraph, wherein the discovered hypergraph is characterized by a plurality of relationships between a plurality of nodes that each represent a variable of a plurality of variables, where the plurality of relationships were discovered by selection of a kernel for a relationship between at least one node of the plurality of nodes and a set of candidate ancestors, and pruning of the set of candidate ancestors to identify a set of minimal ancestors.
A device useful as a spectrometer or a sensor, comprising a source of a short electromagnetic pulses at a first wavelength and having a full width at half maximum in a range of 1 femtosecond- 1 nanosecond; a sample holder in which the short pulses interact with the sample in the sample holder so as to form an output signal comprising a background residual of the short pulses and a sample response signal in the time domain, and an amplifier comprising nonlinear medium. The nonlinear medium comprises an input for receiving the output signal and a pump pulse at a second wavelength, and a second-order nonlinearity configured for a nonlinear process selectively amplifying the sample response signal, for example by temporally overlapping the pump pulse and the sample response signal.
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
G01J 3/02 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur Parties constitutives
Systems and methods for hypergraph discovery in accordance with embodiments of the invention include a method of processing input data, comprising receiving input data at a data processing system, providing the input data to a discovered hypergraph, and generating an output using the discovered hypergraph, wherein the discovered hypergraph is characterized by a plurality of relationships between a plurality of nodes that each represent a variable of a plurality of variables, where the plurality of relationships were discovered by selection of a kernel for a relationship between at least one node of the plurality of nodes and a set of candidate ancestors, and pruning of the set of candidate ancestors to identify a set of minimal ancestors.
Quantum Phased Array(s) of emitters and receivers that generate, modulate, emit, receive, and detect any quantum field. Quantum phased arrays include particle source(s) sourcing any quantum field, transmit modulator element(s) modulating any quantum observable and the associated quantum field, emitting elements radiating one or more quantum fields spatiotemporally, a propagation medium with one or more modulator elements for complete control of the quantum field, receiver(s) receiving one or more quantum fields, receive modulator element(s) modulating any quantum observable and the associated quantum field, detector(s) resolving one or more received quantum fields. Quantum metrology, communication and computing systems including quantum phased arrays are detailed for leveraging quantum field engineering functionality (complete control of one or more wavefunctions of one or more particles in any one or more orthonormal bases) of quantum phased arrays for quantum metrology, communication and computing applications.
Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros.
Automated evaluation of RAP via machine learning is described herein. In one implementation, a method includes: obtaining first video scan data including multiple first video frames of an IVC of a subject, the multiple first video frames including a first video frame of the IVC while the subject is at rest, and a second video frame of the IVC while the subject is inhaling; determining, using a first trained model, based at least on the multiple first video frames, that the first video scan data corresponds to a sniff test of the IVC of the subject; and predicting, using a second trained model, based at least on the multiple first video frames, a RAP of the subject.
Disclosed herein include methods, compositions, and kits suitable for use in programmable cell death control. Compositions (e.g., nucleic acid compositions, synthetic protein circuits) provided herein can comprise one or more apoptosis polypeptides; and/or one or more pyroptosis polypeptides; and/or one or more input polypeptides. In some embodiments, expression of a synthetic protein circuit of the disclosure can induce, e.g., apoptosis and/or pyroptosis in a cell.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12N 9/48 - Hydrolases (3.) agissant sur les liaisons peptidiques, p. ex. thromboplastine, aminopeptidase de la leucine (3.4)
49.
AUTOMATED EVALUATION OF RIGHT ATRIAL PRESSURE VIA MACHINE LEARNING
Automated evaluation of RAP via machine learning is described herein. In one implementation, a method includes: obtaining first video scan data including multiple first video frames of an IVC of a subject, the multiple first video frames including a first video frame of the IVC while the subject is at rest, and a second video frame of the IVC while the subject is inhaling; determining, using a first trained model, based at least on the multiple first video frames, that the first video scan data corresponds to a sniff test of the IVC of the subject; and predicting, using a second trained model, based at least on the multiple first video frames, a RAP of the subject.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
Systems and methods disclosed herein relate to the detection of irregular particles in a blood flow based on a determined relative speed of a particle suspended in a blood flow and/or other properties of a particle suspended in a blood flow including a particle's relative position within a blood vessel and a particles tendency to cluster with other particles suspended in a blood flow. Based on a determined relative speed and/or other relevant factors, the properties of irregular particles may also be measured, including the size, shape, and frequency of irregular particles in a blood flow. Machine learning techniques may be employed to determine patterns for the behavior of irregular particles suspended in a blood flow. These patterns may correspond to particular health risks and conditions.
Disclosed herein include methods, compositions, and kits suitable for use in programmable cell death control. Compositions (e.g., nucleic acid compositions, synthetic protein circuits) provided herein can comprise one or more apoptosis polypeptides; and/or one or more pyroptosis polypeptides; and/or one or more input polypeptides. In some embodiments, expression of a synthetic protein circuit of the disclosure can induce, e.g., apoptosis and/or pyroptosis in a cell.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
Disclosed herein include methods and compositions suitable for use in modulation of aversive taste tolerance. In some embodiments, ingestion of sodium and/or aversive substances is reduced. Also disclosed include methods for identifying modulators for aversive taste tolerance.
A61K 31/5513 - 1,4-Benzodiazépines, p. ex. diazépam
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61P 27/00 - Médicaments pour traiter les troubles des sens
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
53.
SYNTHESIS OF MONOLAYER TRANSITION METAL DICHALCOGENIDES BY ELECTROSTATIC SELF-ASSEMBLY
A method of growing a transition metal dichalcogenide includes providing a substrate and positioning the substrate in a furnace. The method also includes reducing a transition metal compound to produce a plurality of reduced transition metal compounds. The plurality of reduced transition metal compounds is electrostatically aligned on the substrate. The method further includes reacting the plurality of reduced transition metal compounds with a chalcogen precursor to form one or more layers of a transition metal dichalcogenide.
H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
H01M 4/58 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés inorganiques autres que les oxydes ou les hydroxydes, p. ex. sulfures, séléniures, tellurures, halogénures ou LiCoFyEmploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de structures polyanioniques, p. ex. phosphates, silicates ou borates
This disclosure provides HIV immunogens and use thereof for generating an immune response in a subject. Also disclosed is a method of isolating anti-HIV antibodies and use thereof. This disclosure further provides a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject using the disclosed HIV immunogens and/or antibodies.
A new class of weakly coordinating anions (WCA) based on silicates is disclosed. Facile tuning of sterics and solubility of the disclosed WCA may be achieved via variation of R groups. The anions support a range of cations employed in chemical reactivity, including ether-free alkali cations, Ag+, Ph3C+, Fc+, [NiI(COD)2]+. In one aspect, [Pd(dppe)(NCMe)Me]+ may be generated by salt metathesis or protonation of a metal-alkyl bond, showcasing the ability of the anions to support applications in coordination chemistry and catalysis. Electrochemical studies on the [Bu4N]+ variant show an exceptionally wide stability window for the MeSiF24− anion of 7.5 V in MeCN. CV experiments demonstrate reversible Mg deposition and stripping.
A device comprises a photonic integrated circuit comprising an optical parametric oscillator (OPO) outputting at least one of a signal or an idler in response to a pump; and at least one of source for the pump, an external injection locking input, or an auxiliary resonator coupled to the OPO. On-chip generation of coherent radiation, i.e. laser-like radiation, can be tuned over broad and/or hard-to-access wavelength regions in an integrated platform. Target spectral coverage is beyond what could be achieved with existing integrated laser systems.
Techniques for determining stroke risk are provided. In some embodiments, the techniques may involve causing, using one or more light sources disposed on a headset worn by a user, light to be emitted into the head of the user. The techniques may involve obtaining, using one or more light detectors disposed on the headset, information indicative of light reflected from one more structures within the head, wherein a portion of the obtained information spans a time period during which the user was holding their breath. The techniques may involve based on the obtained information, determining one or more cerebral blood metrics. The techniques may involve providing a representation of the one or more cerebral blood metrics as input to a trained machine learning model, and determining a likelihood the user will experience a stroke over a predetermined future time period based on an output of the trained machine learning model.
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
Techniques for monitoring cerebral blood metrics such as cerebral blood flow, cerebral blood volume and/or heart rate are provided. In some embodiments, techniques involve a headset with at least one laser configured to emit light into the brain and one or more light detectors such as CMOS sensors that generate information indicative of light reflected from one or more structures within the brain, which can be used to determine the cerebral blood metrics. Each light detector may be positioned within 5 mm of the scalp in some cases.
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/0255 - Instruments d'enregistrement spécialement adaptés à cet effet
Techniques for monitoring cerebral blood metrics such as cerebral blood flow, cerebral blood volume and/or heart rate are provided. In some embodiments, techniques involve a headset with at least one laser configured to emit light into the brain and one or more light detectors such as CMOS sensors that generate information indicative of light reflected from one or more structures within the brain, which can be used to determine the cerebral blood metrics. Each light detector may be positioned within 5mm of the scalp in some cases.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
Techniques for determining stroke risk are provided. In some embodiments, the techniques may involve causing, using one or more light sources disposed on a headset worn by a user, light to be emitted into the head of the user. The techniques may involve obtaining, using one or more light detectors disposed on the headset, information indicative of light reflected from one more structures within the head, wherein a portion of the obtained information spans a time period during which the user was holding their breath. The techniques may involve based on the obtained information, determining one or more cerebral blood metrics. The techniques may involve providing a representation of the one or more cerebral blood metrics as input to a trained machine learning model, and determining a likelihood the user will experience a stroke over a predetermined future time period based on an output of the trained machine learning model.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
61.
LIQUID ACCOMMODATING INTRAOCULAR LENS WITH AN ASYMMETRIC CHAMBER
An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.
An apparatus including a source of electromagnetic radiation comprising one or more first frequencies; a source of an input signal comprising an alternating (AC) electric field comprising one or more second frequencies; a control circuit synchronizing application of the electromagnetic radiation and the AC electric field applied to a sample, so that an output signal comprising a modulation of the AC electric field is outputted from the sample in response to (1) the one or more second frequencies tuned to drive hopping of ions between ion sites in the sample, and the one or more first frequencies tuned to drive excitations in the sample that interact with the ions. The apparatus further includes a detection system measuring and/or detecting a change in the output signal in response to the electromagnetic radiation; and a computer determining at least one of a conductivity or impedance of the sample from the output signal and as a function of the first frequencies and the second frequencies.
G01N 27/04 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance
63.
Liquid Accommodating Intraocular Lens with Suspended Central Lens
An intraocular lens (IOL) has a small, central lens suspended within a pliable housing and, when the housing is filled with liquid, is coaxially aligned with a second small lens embedded in the wall of the housing. The suspension is on a dome- or other-shaped webbing attached to an inner circumference of the wall. When filled with liquid, forces squeezing or pulling the equator of the housing, as with ciliary muscles in the eye, adjust a distance between the lenses in order to adjust focus. Optional haptics may project from points on or above and below the equator. A recess in the posterior hemisphere of the housing can keep cell growth away from an optical axis of the lens system. A third small lens can be embedded in an opposite wall of the housing and coaxially aligned with the other lenses to form a three-lens, ultra-zoom system.
An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.
Methods and systems for the electrochemical epoxidation of alkenes to generate an epoxide are described herein. Said methods and systems comprise: contacting an anode comprising an oxygen atom transfer electrocatalyst with an alkene in the presence of an electrolyte comprising water; applying a voltage to the anode and a cathode to generate the epoxide; wherein the oxygen atom transfer electrocatalyst comprises an at least partially oxidized palladium-platinum alloy characterized by the formula FX1: PdyPtzOx; wherein y is greater than 0 and less than 1; z is greater than 0 and less than 1; wherein the sum of y and z is equal to 1; and x is selected from the range of 0 to 2. The methods and systems disclosed herein comprise a significant advancement in the electrocatalytic epoxidation of alkenes in aqueous and mixed electrolytes using water as the oxygen atom transfer source.
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
C25B 11/075 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’un seul élément catalytique ou composé catalytique
66.
PALLADIUM-PLATINUM OXIDE CATALYST FOR AQUEOUS ELECTROCHEMICAL DIRECT EPOXIDATION
yzxx; wherein y is greater than 0 and less than 1; z is greater than 0 and less than 1; wherein the sum of y and z is equal to 1; and x is selected from the range of 0 to 2. The methods and systems disclosed herein comprise a significant advancement in the electrocatalytic epoxidation of alkenes in aqueous and mixed electrolytes using water as the oxygen atom transfer source.
Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.
An intraocular lens (IOL) has a small, central lens suspended within a pliable housing and, when the housing is filled with liquid, is coaxially aligned with a second small lens embedded in the wall of the housing. The suspension is on a dome- or other-shaped webbing attached to an inner circumference of the wall. When filled with liquid, forces squeezing or pulling the equator of the housing, as with ciliary muscles in the eye, adjust a distance between the lenses in order to adjust focus. Optional haptics may project from points on or above and below the equator. A recess in the posterior hemisphere of the housing can keep cell growth away from an optical axis of the lens system. A third small lens can be embedded in an opposite wall of the housing and coaxially aligned with the other lenses to form a three-lens, ultra-zoom system.
The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
70.
AUXILIARY GYROSCOPE APPROACH FOR BALANCED PERFORMANCE VIA GYRO SELF-CALIBRATION
Methods and devices for bias gyroscopes self-calibration are disclosed. The described teachings can be applied to inertial measurement units implementing one or more auxiliary Coriolis Vibratory Gyroscope (CVG) in conjunction with one or more primary gyroscopes. The auxiliary CVG, capable of mode-switching, enables continuous bias estimation for both its own operation and those of the primary gyroscopes without relying on external aiding sensors. The disclosed methods implement a Kalman filter for bias estimation and can update estimates either at every measurement time step or at mode switching intervals. By combining the good noise performance of primary gyroscopes with the bias stability improvement from the auxiliary CVG, an enhanced overall performance can be achieved.
G01C 19/5776 - Traitement de signal non spécifique à l'un des dispositifs couverts par les groupes
G01C 25/00 - Fabrication, étalonnage, nettoyage ou réparation des instruments ou des dispositifs mentionnés dans les autres groupes de la présente sous-classe
71.
ATOMIC LAYER ETCHING FOR SMOOTHING OF ARBITRARY SURFACES
A method for etching a surface including obtaining a substrate comprising a material; reacting a surface of a substrate with a reactant, comprising a gas or a plasma, to form a reactive layer on the substrate, the reactive layer comprising a chemical compound including the reactant and the material; and wet etching or dissolving the reactive layer with a liquid wet etchant of solvent that selectively etches or dissolves the reactive layer but not the substrate.
H01L 21/67 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitementAppareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants
H01L 21/677 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitementAppareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants pour le transport, p. ex. entre différents postes de travail
72.
CLEAVE AND RESCUE GAMETE KILLERS FOR GENE DRIVE IN PLANTS
Described herein are embodiments relating to manipulation of the composition, numbers and sex ratio in plant populations through DNA sequence modifications.
Described herein are embodiments relating to manipulation of the composition, numbers and sex ratio in plant populations through DNA sequence modifications.
Lithium niobate (LiNbO3, LN) is a ferroelectric crystal of interest for integrated photonics owing to its large second-order optical nonlinearity and the ability to impart periodic poling via an external electric field. However, on-chip device performance based on thin-film lithium niobate (TFLN) is presently limited by propagation losses arising from surface roughness on the nano- and microscale. Atomic layer etching (ALE) can smooth these features and thereby increase photonic performance. In one embodiment disclosed herein, an isotropic ALE process for x-cut MgO-doped LN uses sequential exposures of H2 and SF6/Ar plasmas. We observed an etch rate of 1.59±0.02 nm/cycle with a synergy of 96.9%. ALE can be achieved with SF6/O2 or Cl2/BCl3 plasma exposures in place of the SF6/Ar plasma step with synergies of 99.5% and 91.5% respectively. The process decreased the sidewall surface roughness of TFLN waveguides etched by physical Ar+ milling by 30% without additional wet processing.
H10N 30/082 - Mise en forme ou usinage de corps piézo-électriques ou électrostrictifs par gravure, p. ex. par lithographie
H01L 21/67 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitementAppareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants
75.
Systems and Methods for Communicating by Modulating Data on Zeros in the Presence of Channel Impairments
Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol remitting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.
Bistable devices are constructed using a polynucleotide platform for the sensing of molecular events such as binding or conformational changes of target molecules. Uses include measurement of target concentration, measuring the effect of environmental condition (such as heat, light, or pH) on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices comprise three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Devices carry DNA tags to enable separation of open and closed devices, as well as barcoding for multiplexed detection.
The present invention relates to broadly neutralizing anti-HIV-1 antibodies and isolated antigens. Also disclosed are related methods and compositions.
C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
A61K 39/21 - Retroviridae, p. ex. virus de l'anémie infectieuse équine
A61K 39/42 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire viraux
A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
In many embodiments of the invention, a space-based data center includes orbital server modules configured to be deployed in space, each module including a communication subsystem for module-to-module communications to form a data center, tiles arranged in a planar array, where each tile has a layered structure including solar cells forming a layer across a first surface, thermal radiator panels forming a layer across a second surface, electronic components distributed laterally in a layer between the layer of solar cells and the layer of thermal radiator panels, where each electronic component receives power locally from solar cells and rejects heat to the thermal radiator panel beneath it, where a first subset of tiles are compute tiles in which the electronic components include one or more computing processors and memory, and where a second subset of tiles are support tiles in which the electronics components include network switches and energy storage.
Disclosed herein include methods, compositions, and kits suitable for use in tuned dosage-invariant expression of a payload protein. Compositions (e.g., nucleic acid compositions, one or more cells) provided herein can comprise a first promoter sequence operably linked to a first polynucleotide comprising one or more miRNA cassettes, and a second promoter sequence operably linked to a second polynucleotide comprising a payload gene. In some embodiments, the first promoter sequence is capable of inducing transcription of the first polynucleotide to generate a first transcript, and the first transcript is capable of being processed to generate said miRNA. The payload gene can comprise a miRNA target region comprising one or more miRNA target sequences.
A circuit comprising a first Fourier Transform block operable to perform a Fourier Transform and having a first input configured for receiving an I signal and a second input configured for receiving a Q signal; a first plurality of n of outputs for I channels and Q channels each comprising a different frequency bin output from the Fourier Transform; I and Q summing blocks comprising a set of connector lines connecting an ith one of I channels with an ith one of the Q channels; an inverse Fourier Transform block connected to the summing blocks and operable to perform an inverse Fourier Transform; a correlator for correlating the outputs of the inverse Fourier Transform; a Fourier Transform block for Fourier Transforming the correlator output; a comparator for comparing the correlation term to zero; and an error correction circuit for tuning the magnitude and phase of the I and Q channels using the comparator output as feedback.
Devices for the assembly of structures are described. More specifically, devices designed for the assembly of structures in space are described, with a particular focus on antenna structures and methods for their assembly and deployment in space. Even more specifically, it addresses the construction of mesh reflector antennas in space. The invention includes devices, systems, and methods designed to facilitate the creation and deployment of these antennas in a space environment by leveraging advanced assembly techniques.
Disclosed herein are analogs and derivatives of aleutianamine and methods of making the same. Also disclosed herein are methods of treating pancreatic cancer comprising administration of aleutianamine or its analogs.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
Disclosed herein include methods, compositions, and kits suitable for use in tuned dosage-invariant expression of a payload protein. Compositions (e.g., nucleic acid compositions, one or more cells) provided herein can comprise a first promoter sequence operably linked to a first polynucleotide comprising one or more miRNA cassettes, and a second promoter sequence operably linked to a second polynucleotide comprising a payload gene. In some embodiments, the first promoter sequence is capable of inducing transcription of the first polynucleotide to generate a first transcript, and the first transcript is capable of being processed to generate said miRNA. The payload gene can comprise a miRNA target region comprising one or more miRNA target sequences.
Described herein are compositions having an eight-membered monocyclic unsaturated hydrocarbon, methods and system to separate the eight-membered monocyclic unsaturated hydrocarbon at from a hydrocarbon mixture including additional nonlinear unsaturated C8H2m hydrocarbons with 4≤m≤8, by contacting the hydrocarbon mixture with a 10-ring pore molecular sieve having a sieving channel with a 10-ring sieving aperture with a minimum crystallographic free diameter greater than 3 Å and a ratio of the maximum crystallographic free diameter to the minimum crystallographic free diameter between 1 and 2, the molecular sieve having a T1/T2 ratio ≥20:1 wherein T1 is an element independently selected from Si and Ge, and T2 is an element independently selected from Al, B and Ga, the 10-ring pore molecular sieve further having a counterion selected from NH4+, Li+, Na+, K+ and Ca++.
C07C 7/13 - Purification, séparation ou stabilisation d'hydrocarburesEmploi d'additifs par adsorption, c.-à-d. purification ou séparation d'hydrocarbures à l'aide de solides, p. ex. à l'aide d'échangeurs d'ions par la technique du tamis moléculaire
C07C 13/263 - Hydrocarbures monocycliques ou leurs dérivés hydrocarbonés acycliques à cycle octogonal à cycle du cyclo-octène ou du cyclo-octadiène
C08G 61/08 - Composés macromoléculaires contenant uniquement des atomes de carbone dans la chaîne principale de la molécule, p. ex. polyxylylènes uniquement des atomes de carbone aliphatiques préparés par ouverture du cycle des composés carbocycliques des composés carbocycliques contenant une ou plusieurs doubles liaisons carbone-carbone dans le cycle
85.
OPTICAL FIBER-BASED TSUNAMI WARNING SYSTEM USING SUBMARINE TELECOMMUNICATION CABLES
The invention describes a tsunami warning system utilizing properties of light in optical fibers within submarine telecommunication cables. Enhanced by microwave frequency modulation and High-Loss Loop Back (HLLB) techniques, this system measures photoelastic changes for more stable, long-period tsunami wave detection.
G01L 11/02 - Mesure de la pression permanente, ou quasi permanente d'un fluide ou d'un matériau solide fluent par des moyens non prévus dans les groupes ou par des moyens optiques
G01L 1/24 - Mesure des forces ou des contraintes, en général en mesurant les variations des propriétés optiques du matériau quand il est soumis à une contrainte, p. ex. par l'analyse des contraintes par photo-élasticité
G01V 1/38 - SéismologieProspection ou détection sismique ou acoustique spécialement adaptées aux zones recouvertes d'eau
G01H 9/00 - Mesure des vibrations mécaniques ou des ondes ultrasonores, sonores ou infrasonores en utilisant des moyens sensibles aux radiations, p. ex. des moyens optiques
Hyper-Heisenberg scaling quantum imaging techniques that pass an idler photon of each entangled photon pair three times through an idler objective pair and pass a signal photon of each entangled photon pair at least once through a signal objective pair and use measurements of coincidence detection to yield a coincidence image with spatial resolution of about four times that of classical imaging.
The present invention relates to methods of treating breast cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein. In some embodiments the subject can be receiving chemotherapy with a conventional chemotherapy drug and/or a therapeutic monoclonal antibody or drug conjugate thereof.
A61K 31/337 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à quatre chaînons, p. ex. taxol
A61K 31/7072 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique ayant deux groupes oxo liés directement au cycle pyrimidine, p. ex. uridine, acide uridylique, thymidine, zidovudine
C07H 1/00 - Procédés de préparation des dérivés du sucre
An on-chip pulse synthesizer including an integrated photonic chip that temporally and spectrally shapes pulses of light using primarily quadratic optical nonlinearities. Through this synthesis, the light pulses undergo temporal shortening or reshaping, spectral broadening, wavelength conversion, or a combination thereof. A key aspect of this synthesis is the mode engineering of the waveguides, which includes converting the pump source mode to the relevant mode in the nonlinear optical region and tailoring the waveguide geometry and material stack to enable dispersion-engineering as well as engineering of the phase matching for various nonlinear processes.
G02F 1/365 - Optique non linéaire dans une structure de guide d'ondes optique
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
G02F 1/39 - Optique non linéaire pour la génération ou l'amplification paramétrique de la lumière, des infrarouges ou des ultraviolets
89.
METHOD FOR TRANSFERRING A PRESSURE WAVE FROM PERIPHERAL SITE TO CENTRAL SITE
The disclosure relates to techniques for transferring a pulse pressure waveform signal of a peripheral vascular site to a central vascular site. In some implementations, a method includes: obtaining a time-domain representation of a first pulse pressure waveform signal of a brachial artery of a subject; converting the time-domain representation of the first pulse pressure waveform signal to a frequency-domain representation of the first pulse pressure waveform signal; selecting a first plurality of frequency components of the frequency-domain representation of the first pulse pressure waveform signal; predicting, using a non-linear mapping, based on the first plurality of frequency components, a second plurality of frequency components of a frequency-domain representation of a second pulse pressure waveform signal of an ascending aorta or left ventricle of the subject; and converting the frequency-domain representation of the second pulse pressure waveform signal to a time-domain representation of the second pulse pressure waveform signal.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/025 - Mesure du pouls ou des pulsations cardiaques utilisant des capteurs engendrant des signaux électriques à l'intérieur de dispositifs d'occlusion, p. ex. en réponse à des bruits de Korotkoff
90.
OPTICAL FIBER-BASED TSUNAMI WARNING SYSTEM USING SUBMARINE TELECOMMUNICATION CABLES
The invention describes a tsunami warning system utilizing properties of light in optical fibers within submarine telecommunication cables. Enhanced by microwave frequency modulation and High-Loss Loop Back (HLLB) techniques, this system measures photoelastic changes for more stable, long-period tsunami wave detection.
G08B 21/10 - Alarmes pour assurer la sécurité des personnes réagissant aux événements désastreux, p. ex. les tornades ou les tremblements de terre
G01L 11/02 - Mesure de la pression permanente, ou quasi permanente d'un fluide ou d'un matériau solide fluent par des moyens non prévus dans les groupes ou par des moyens optiques
This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G06F 17/11 - Opérations mathématiques complexes pour la résolution d'équations
G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
G16B 25/00 - TIC spécialement adaptées à l’hybridationTIC spécialement adaptées à l’expression de gènes ou de protéines
G16B 25/20 - Réaction en chaîne par polyméraseConception d’amorces ou de sondesOptimisation de la sonde
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase
92.
COMPOSITIONS FOR TRANSPORT OF THERAPEUTIC CARGOS USING ANTIBODY BINDERS TARGETING CA-IV
The present invention provides compositions and methods comprising antibodies as shuttles for the BBB-crossing, for example through the receptor carbonic anhydrase IV (CA-IV).
A61K 47/66 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant une protéine, un peptide ou un acide polyaminé l’agent de modification étant un système de pré-ciblage impliquant un peptide ou une protéine pour cibler des cellules spécifiques
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
The present invention provides compositions and methods comprising brinzolamide and brinzolamide derivates as shuttles for the BBB-crossing, for example through the receptor carbonic anhydrase IV (CA-IV).
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
94.
COMPOSITIONS FOR TRANSPORT OF THERAPEUTIC CARGOS USING MINIPROTEIN BINDERS TARGETING CA-IV
The present invention provides compositions and methods comprising miniproteins as shuttles inducing transcytosis across target tissues, for example through an astrocyte-specific receptor, neuron-specific receptor, carbonic anhydrase IV (CA-IV), low density lipoprotein receptor related protein 6 (LRP6), or lymphocyte antigen 6 complex, locus A (LY6A).
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
95.
MOLECULAR RECORDING METHODS AND SYSTEMS TO CAPTURE LINEAGE RELATIONSHIPS IN DIFFERENTIATING STEM CELLS
Disclosed herein include methods, compositions, and kits suitable for use in capturing lineage relationships in dividing cell populations. Disclosed herein include compact phylogenetic recording systems for high resolution lineage reconstruction over long time scales. In some embodiments, the system comprises one or more hypercascade array(s) each comprising p hypercascade units, n layer guide RNAs, and an editor. In some embodiments, the system comprises one or more target array(s) comprising n editable target sites, n guide RNAs gRNAs, and a base editor capable of adenine (A)-to-guanine (G) base editing.
Imaging methods and apparatus for localizing biopsy needles coupled to an ultrasonic transmitter and/or monitoring ablation of an ablation probe connected to a microwave source, which include an arbitrary waveform generator for generating a chirp signal that excites the ultrasonic transmitter to generate an ultrasonic signal or modulates the microwave signal.
Systems and methods for a wearable system that monitors various biomarkers with a 3D-printed wearable electronic skin. Specifically, the wearable system is a 3D-printed epidermal wearable microfluidic electronic skin that may be composed of a combination of multidimensional nanomaterials, polymers, and hydrogels. The epidermal wearable microfluidic electronic skin may be integrated with sensors, electrodes, microfluidics, and a processor to collect and analyze molecular biomarkers of biofluid samples on the user's skin, while simultaneously analyzing the user's physiological biomarkers to conduct a health status assessment or gather health monitoring/surveillance metric.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
Methods and systems are described of a stochastic quantitative approach (StochQuant) that uses molecular counts obtained from a testing measurement, an absolute anchoring measurement of a reference molecule, and possibly additional physical parameters such as quantitatively measurable amounts of a sample, to identify a probability distribution, a confidence interval and/or a confidence level in outcome of a testing measurement of a target molecule, thus improving reliability and accuracy of quantitative detection of the target molecule performed by the testing measurement.
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
G16B 45/00 - TIC spécialement adaptées à la visualisation de données liées à la bio-informatique, p. ex. affichage de cartes ou de réseaux
G16B 50/00 - TIC pour la programmation d’outils ou de systèmes de bases de données spécialement adaptées à la bio-informatique
G16B 20/00 - TIC spécialement adaptées à la génomique ou protéomique fonctionnelle, p. ex. corrélations génotype-phénotype
99.
3D-Printed Epidermal Wearable Microfluidic Electronic Skin for Machine Learning-Powered Multimodal Health Surveillance
Systems and methods for a wearable system that monitors various biomarkers with a 3D-printed wearable electronic skin. Specifically, the wearable system is a 3D-printed epidermal wearable microfluidic electronic skin that may be composed of a combination of multidimensional nanomaterials, polymers, and hydrogels. The epidermal wearable microfluidic electronic skin may be integrated with sensors, electrodes, microfluidics, and a processor to collect and analyze molecular biomarkers of biofluid samples on the user's skin, while simultaneously analyzing the user's physiological biomarkers to conduct a health status assessment or gather health monitoring/surveillance metric.
G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
B29C 48/00 - Moulage par extrusion, c.-à-d. en exprimant la matière à mouler dans une matrice ou une filière qui lui donne la forme désiréeAppareils à cet effet
B33Y 80/00 - Produits obtenus par fabrication additive
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition.
