A method and system provide the ability to compile computer code. Human readable text in a programming language is optimized in a compiler, into a processor specific language. The optimization includes determining a set of two or more optimization routines, randomly selecting a selected optimization routine from the set of two or more optimization routines, and applying the selected optimization routine to each segment of the human readable text. Binary code is then output based on the optimized human readable text and has improved resistance to subversion.
Computational refocusing-assisted deep learning methods, apparatus, and systems are described. In certain pathology examples, a representative image is generated using a machine learning model trained with uniformly focused training images generated by a Fourier ptychographic digital refocusing procedure and abnormalities are automatedly identified and/or enumerated based on the representative image.
A measurement device includes: a processing device and multiple sensors that capture tomographic information of a physiological structure. The sensors include a first sensor including a first transducer having a first frequency response with a first resonant frequency, and a second sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits a signal that is reflected by the physiological structure to create a reflected signal, the first transducer generates a first received signal from the reflected signal, the second transducer generates a second received signal from the reflected signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.
Methods and systems are described of a stochastic quantitative approach (StochQuant) that uses molecular counts obtained from a testing measurement, an absolute anchoring measurement of a reference molecule, and possibly additional physical parameters such as quantitatively measurable amounts of a sample, to identify a probability distribution, a confidence interval and/or a confidence level in outcome of a testing measurement of a target molecule, thus improving reliability and accuracy of quantitative detection of the target molecule performed by the testing measurement.
A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.
H01G 11/14 - Arrangements or processes for adjusting or protecting hybrid or EDL capacitors
H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte
6.
REDOX-ACTIVE COMPOUNDS AND RELATED COMPOUNDS, COMPOSITIONS, METHODS AND SYSTEMS
Compounds able to affect production and/or activity of a redox active compound, which include candidate therapeutic compounds and candidate compounds for enhancing power output of a microbial fuel cell, and related compositions, methods and systems.
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
7.
GAS VESICLE EXPRESSION SYSTEMS, GAS VESICLE CONSTRUCTS AND RELATED GENETIC CIRCUITS, VECTORS, MAMMALIAN CELLS, HOSTS, COMPOSITIONS, METHODS AND SYSTEMS
Provided herein are genetically engineered gas vesicle expression systems (GVES) that are configured to express gas vesicles (GVs) in a mammalian cell, related gas vesicle polynucleotide constructs, gas vesicle reporting genetic circuits, vectors, genetically engineered mammalian cells, non-human mammalian hosts, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging techniques to detect and report biological events in an imaging target site comprising a mammalian cell and/or organism.
A device including a photonic integrated circuit comprising one or more OPOs each comprising: an input configured to receive a pump wave comprising pulses or a frequency comb with a pump repetition rate, one or a plurality of nonlinear sections as part of a resonator or coupled to a resonator having a free spectral range, where at least one of the free spectral range or one of its harmonics is matched to the pump repetition rate or its harmonics, and one or a plurality of outputs configured to extract a portion of the waves generated by the OPO in response to the pump wave and/or the pump wave.
The present invention uses tunable or broadband integrated OPO with active or passive beam steering devices for high-speed ranging on a compact, low-cost platform. Examples of beam steering devices include grating couplers, optical phased arrays, arrayed waveguide delay lines, nanophotonic antennas, metasurfaces, etc. The beam steering device can be inside or outside of the OPO structure. Under broadband operation, the angular information is encoded in the spectral domain and vice versa, and the detector may have multiple spectral filters corresponding to different angles or a single tunable filter. The tunable filter can be electro-optic (EO) based or piezoelectric (PZT)-based. This invention can be realized across multiple material platforms with application specific parameters to optimize performance, such as bandwidth, tuning range, tuning speed, spatial/temporal resolution, polarization, field of view (FOV), etc. Scanning can be done in 1D and 2D. Multiple OPOs can be fabricated on chip with multiple beam steering devices.
G01S 17/10 - Systems determining position data of a target for measuring distance only using transmission of interrupted, pulse-modulated waves
G01S 17/34 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated using transmission of continuous, frequency-modulated waves while heterodyning the received signal, or a signal derived therefrom, with a locally-generated signal related to the contemporaneously transmitted signal
G02B 6/00 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
10.
BIPEDAL ROBOT WITH INTEGRATED THRUSTER-ASSISTED LOCOMOTION
A bipedal robot having a legged assembly and an aerial assembly is described. The legged assembly includes two legs, each leg having a hip frontal joint, a hip sagittal joint, and a knee joint. The aerial assembly includes two thrusters mounted on a carbon fiber-aluminum composite mount. Actuators for the joints include 3D printed housings with embedded components. A controller generates walking trajectories and controls the thrusters to assist with stabilization and obstacle traversal. The robot is capable of dynamic multimodal locomotion, combining legged movement with thruster-assisted stabilization and jumping to navigate challenging terrain.
B60F 5/02 - Other vehicles capable of travelling in or on different media convertible into aircraft
B62D 57/032 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted supporting base and legVehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted feet or skid
Systems and methods are provided for a wearable mask that analyzes exhaled breath condensate (EBC) for health monitoring. Specifically, the wearable mask is a smart mask designed to harvest and analyze EBC in real- or near-real-time, and provide insights into the wearer's respiratory and metabolic health. The smart mask incorporates tandem passive cooling technologies, automated microfluidics, selective electrochemical biosensing, and wireless communication within the mask's framework. This integration allows for non-invasive, continuous monitoring of various biomarkers present in the EBC across different environments, enabling personalized health surveillance during regular daily activities. The smart mask is capable of detecting a broad spectrum of biomarkers, including volatile organic compounds (VOCs), nitric oxide, cytokines, and pathogens indicative of respiratory conditions.
The present invention uses tunable or broadband integrated OPO with active or passive beam steering devices for high-speed ranging on a compact, low-cost platform. Examples of beam steering devices include grating couplers, optical phased arrays, arrayed waveguide delay lines, nanophotonic antennas, metasurfaces, etc. The beam steering device can be inside or outside of the OPO structure. Under broadband operation, the angular information is encoded in the spectral domain and vice versa, and the detector may have multiple spectral filters corresponding to different angles or a single tunable filter. The tunable filter can be electro-optic (EO) based or piezoelectric (PZT)-based. This invention can be realized across multiple material platforms with application specific parameters to optimize performance, such as bandwidth, tuning range, tuning speed, spatial/temporal resolution, polarization, field of view (FOV), etc. The scanning can be done in 1D and 2D. Multiple OPOs can be fabricated on the same chip along with multiple beam steering devices, to extend the wavelength tuning range and subsequent FOV in 1D and 2D scanning.
G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves
G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection
H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
G01S 17/34 - Systems determining position data of a target for measuring distance only using transmission of continuous waves, whether amplitude-, frequency-, or phase-modulated, or unmodulated using transmission of continuous, frequency-modulated waves while heterodyning the received signal, or a signal derived therefrom, with a locally-generated signal related to the contemporaneously transmitted signal
G01S 7/481 - Constructional features, e.g. arrangements of optical elements
13.
A SMART MASK FOR EXHALED BREATH CONDENSATE HARVESTING AND ANALYSIS
Systems and methods are provided for a wearable mask that analyzes exhaled breath condensate (EBC) for health monitoring. Specifically, the wearable mask is a smart mask designed to harvest and analyze EBC in real- or near-real-time, and provide insights into the wearer's respiratory and metabolic health. The smart mask incorporates tandem passive cooling technologies, automated microfluidics, selective electrochemical biosensing, and wireless communication within the mask's framework. This integration allows for non-invasive, continuous monitoring of various biomarkers present in the EBC across different environments, enabling personalized health surveillance during regular daily activities. The smart mask is capable of detecting a broad spectrum of biomarkers, including volatile organic compounds (VOCs), nitric oxide, cytokines, and pathogens indicative of respiratory conditions.
A system of a multi-rotor aircraft that capitalizes on the advantages of fixed wing elements combined with rotary wing structures. The fixed wing elements can help to generate lift once the aircraft is airborne and can thus reduce the need for larger lifting rotors which can allow for longer flight times and distances. Additionally, the systems disclosed herein take advantage of a partial in-wing configuration with a number of rotors to reduce the overall footprint of the vehicle while maintaining the flight efficiency that comes with combining features of fixed and rotary wing elements, and increasing operator safety by shrouding rotating parts. The unique configurations allow for a decoupling of the pitch, yaw and roll authority to reduce the complexity in control systems and improve the flight efficiency of the aircraft. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque.
Described herein are systems for determining an absence, or presence and size of particles in a liquid pharmaceutical product. The systems may comprise a Mie-scattering-based light sheet (MSLS) liquid particle analyzer. Described herein are method for determining an absence, or presence and size of particles in a liquid pharmaceutical product.
A high-power density electric propulsion (EP) system is presented. High-power density functionality of the EP system is provided via thermal management structures that separately manage heat from a discharge chamber with electrically conductive inner/outer walls and an electromagnetic circuit of the EP system. The thermal management structures include separate radiators for rejection of heat from the discharge chamber and the electromagnetic circuit, the heat coupled to the radiators via respective thermal shunts. The thermal shunts include radially inwardly and/or outwardly projecting heat conducting structures that are thermally coupled to the discharge chamber and the electromagnetic circuit. Openings formed in annular structures of the electromagnetic circuit allow radial projection of the thermal shunts.
Nonlinear ultrasound imaging techniques that send ultrasound transmissions with multiple frequency or phase cycles for exciting and imaging nonlinear scatterers such as acoustic biomolecules. an ultrasound imaging system includes an arrangement of transducer elements (e.g., an ultrasound probe) and a plurality of apertures of different sets of transducer elements in the arrangement of transducer elements. Each transducer element of each aperture is configured to generate an acoustic wave when activated by a transmission signal having a plurality of cycles. The acoustic waves generated by each set of transducer elements of each aperture form an acoustic beam along an axis.
Some aspects of the present disclosure relate to methods and devices for identifying soil bacteria-enriching agents that selectively enrich a desired species of bacteria in a soil microbiome. In some embodiments, the soil bacteria-enriching agent comprises a carbon substrate and/or a chemoeffector. Some aspects of the present disclosure relate to methods of enriching a desired species of bacteria in a soil microbiome using one or more soil bacteria-enriching agents.
Nonlinear ultrasound imaging techniques that send ultrasound transmissions with multiple frequency or phase cycles for exciting and imaging nonlinear scatterers such as acoustic biomolecules.
An entertainment system generates a tone mark in response to a tone mark generating operation performed by a first player, move the tone mark toward a second player area, generates a tone mark in response to a tone mark generating operation performed by a second player, and moves the tone mark toward a first player area. When the tone mark generated by the second player arrives at the first player area, whether the first player performs a tone output operation is determined. When the tone mark generated by the first player arrives at the second player area, whether the second player performs a tone output operation is determined. Communication points are calculated based on the tone mark generating operation and the tone output operation by the first player and the tone mark generating operation and the tone output operation by the second player.
Disclosed herein include method and systems suitable for use in detection and/or prediction of microorganisms in a sample using sequencing data. In some embodiments, the method comprises converting reference sequences and sample sequences to comma-free sample codes; and detecting the presence of microbes in the sample based on alignment of the comma-free codes. In some embodiments, the method comprises detecting and/or predicting viral presence in host cell, by identifying and analyzing signature host genes. In some embodiments, the system suitable for performing the methods disclosed herein.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
Disclosed herein include method and systems suitable for use in detection and/or prediction of microorganisms in a sample using sequencing data. In some embodiments, the method comprises converting reference sequences and sample sequences to comma-free sample codes; and detecting the presence of microbes in the sample based on alignment of the comma-free codes. In some embodiments, the method comprises detecting and/or predicting viral presence in host cell, by identifying and analyzing signature host genes. In some embodiments, the system suitable for performing the methods disclosed herein.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
Described herein are compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms showing increased specificity and efficiency of viral transduction in targeted cell-types, for e.g., the brain, and lung. The rAAV compositions described herein also have tropisms showing decreased specificity and decreased efficiency of viral transduction in an off-target cell type, for e.g., the liver. The rAAV compositions described herein encapsidate a transgene, such a therapeutic nucleic acid. Upon systemic delivery to a subject, the rAAV is capable of increased specificity and increased transduction of the transgene in a target cell-type, as compared to a parental or reference AAV.
A device useful as a spectrometer or a sensor, comprising a source of a short electromagnetic pulses at a first wavelength and having a full width at half maximum in a range of 1 femtosecond-1 nanosecond; a sample holder in which the short pulses interact with the sample in the sample holder so as to form an output signal comprising a background residual of the short pulses and a sample response signal in the time domain, and an amplifier comprising nonlinear medium. The nonlinear medium comprises an input for receiving the output signal and a pump pulse at a second wavelength, and a second-order nonlinearity configured for a nonlinear process selectively amplifying the sample response signal, for example by temporally overlapping the pump pulse and the sample response signal.
Improved prosthetic valves, their methods of manufacture, and systems and devices for manufacturing the valves are described. The prosthetic valves can be configured for transcatheter implantation. The prosthetic valves can have artificial leaflets. The prosthetic valves can be manufactured in numerous ways, such as by polymeric dipping processes and/or electrospinning. Sponge-like polymers for valves and other medical devices are also disclosed.
The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
C07H 15/04 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical
A01N 37/36 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio-analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
A01N 43/38 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/7028 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
C07H 15/10 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical containing unsaturated carbon-to-carbon bonds
C07H 15/18 - Acyclic radicals, substituted by carbocyclic rings
C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
28.
ULTRASENSITIVE MOLECULAR DETECTION VIA HYBRIDIZATION CHAIN REACTION
The present application relates to hybridization chain reaction (HCR). In particular, compositions and methods are presented for ultrasensitive molecular detection using HCR signal amplification. Some embodiments and methods involve cooperative probe junctions, reporter-labeled probes, and nonlinear HCR signal amplification.
ELECTRON-DEFICIENT PHOSPHINE-PHOSPHONIUM-PHENOL SUPPORTED NICKEL(II) AND PALLADIUM(II) CATALYSTS FOR THE COPOLYMERIZATION OF ETHYLENE AND ACRYLATE COMONOMERS
Processes of polymerizing olefin monomers, including polar comonomers, using catalyst systems and catalysts systems that include a procatalyst having a structure according to formula (I).
C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
C08F 4/80 - MetalsMetal hydridesMetallo-organic compoundsUse thereof as catalyst precursors selected from metals not provided for in group selected from iron group metals or platinum group metals
30.
SYSTEMS AND METHODS FOR CO-DISCOVERING GRAPHICAL STRUCTURE AND FUNCTIONAL RELATIONSHIPS WITHIN DATA
Systems and methods for hypergraph discovery in accordance with embodiments of the invention include a method of processing input data, comprising receiving input data at a data processing system, providing the input data to a discovered hypergraph, and generating an output using the discovered hypergraph, wherein the discovered hypergraph is characterized by a plurality of relationships between a plurality of nodes that each represent a variable of a plurality of variables, where the plurality of relationships were discovered by selection of a kernel for a relationship between at least one node of the plurality of nodes and a set of candidate ancestors, and pruning of the set of candidate ancestors to identify a set of minimal ancestors.
A device useful as a spectrometer or a sensor, comprising a source of a short electromagnetic pulses at a first wavelength and having a full width at half maximum in a range of 1 femtosecond- 1 nanosecond; a sample holder in which the short pulses interact with the sample in the sample holder so as to form an output signal comprising a background residual of the short pulses and a sample response signal in the time domain, and an amplifier comprising nonlinear medium. The nonlinear medium comprises an input for receiving the output signal and a pump pulse at a second wavelength, and a second-order nonlinearity configured for a nonlinear process selectively amplifying the sample response signal, for example by temporally overlapping the pump pulse and the sample response signal.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
Systems and methods for hypergraph discovery in accordance with embodiments of the invention include a method of processing input data, comprising receiving input data at a data processing system, providing the input data to a discovered hypergraph, and generating an output using the discovered hypergraph, wherein the discovered hypergraph is characterized by a plurality of relationships between a plurality of nodes that each represent a variable of a plurality of variables, where the plurality of relationships were discovered by selection of a kernel for a relationship between at least one node of the plurality of nodes and a set of candidate ancestors, and pruning of the set of candidate ancestors to identify a set of minimal ancestors.
Quantum Phased Array(s) of emitters and receivers that generate, modulate, emit, receive, and detect any quantum field. Quantum phased arrays include particle source(s) sourcing any quantum field, transmit modulator element(s) modulating any quantum observable and the associated quantum field, emitting elements radiating one or more quantum fields spatiotemporally, a propagation medium with one or more modulator elements for complete control of the quantum field, receiver(s) receiving one or more quantum fields, receive modulator element(s) modulating any quantum observable and the associated quantum field, detector(s) resolving one or more received quantum fields. Quantum metrology, communication and computing systems including quantum phased arrays are detailed for leveraging quantum field engineering functionality (complete control of one or more wavefunctions of one or more particles in any one or more orthonormal bases) of quantum phased arrays for quantum metrology, communication and computing applications.
Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros.
Automated evaluation of RAP via machine learning is described herein. In one implementation, a method includes: obtaining first video scan data including multiple first video frames of an IVC of a subject, the multiple first video frames including a first video frame of the IVC while the subject is at rest, and a second video frame of the IVC while the subject is inhaling; determining, using a first trained model, based at least on the multiple first video frames, that the first video scan data corresponds to a sniff test of the IVC of the subject; and predicting, using a second trained model, based at least on the multiple first video frames, a RAP of the subject.
Disclosed herein include methods, compositions, and kits suitable for use in programmable cell death control. Compositions (e.g., nucleic acid compositions, synthetic protein circuits) provided herein can comprise one or more apoptosis polypeptides; and/or one or more pyroptosis polypeptides; and/or one or more input polypeptides. In some embodiments, expression of a synthetic protein circuit of the disclosure can induce, e.g., apoptosis and/or pyroptosis in a cell.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C12N 9/48 - Hydrolases (3.) acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
37.
AUTOMATED EVALUATION OF RIGHT ATRIAL PRESSURE VIA MACHINE LEARNING
Automated evaluation of RAP via machine learning is described herein. In one implementation, a method includes: obtaining first video scan data including multiple first video frames of an IVC of a subject, the multiple first video frames including a first video frame of the IVC while the subject is at rest, and a second video frame of the IVC while the subject is inhaling; determining, using a first trained model, based at least on the multiple first video frames, that the first video scan data corresponds to a sniff test of the IVC of the subject; and predicting, using a second trained model, based at least on the multiple first video frames, a RAP of the subject.
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Systems and methods disclosed herein relate to the detection of irregular particles in a blood flow based on a determined relative speed of a particle suspended in a blood flow and/or other properties of a particle suspended in a blood flow including a particle's relative position within a blood vessel and a particles tendency to cluster with other particles suspended in a blood flow. Based on a determined relative speed and/or other relevant factors, the properties of irregular particles may also be measured, including the size, shape, and frequency of irregular particles in a blood flow. Machine learning techniques may be employed to determine patterns for the behavior of irregular particles suspended in a blood flow. These patterns may correspond to particular health risks and conditions.
Disclosed herein include methods, compositions, and kits suitable for use in programmable cell death control. Compositions (e.g., nucleic acid compositions, synthetic protein circuits) provided herein can comprise one or more apoptosis polypeptides; and/or one or more pyroptosis polypeptides; and/or one or more input polypeptides. In some embodiments, expression of a synthetic protein circuit of the disclosure can induce, e.g., apoptosis and/or pyroptosis in a cell.
Disclosed herein include methods and compositions suitable for use in modulation of aversive taste tolerance. In some embodiments, ingestion of sodium and/or aversive substances is reduced. Also disclosed include methods for identifying modulators for aversive taste tolerance.
A method of growing a transition metal dichalcogenide includes providing a substrate and positioning the substrate in a furnace. The method also includes reducing a transition metal compound to produce a plurality of reduced transition metal compounds. The plurality of reduced transition metal compounds is electrostatically aligned on the substrate. The method further includes reacting the plurality of reduced transition metal compounds with a chalcogen precursor to form one or more layers of a transition metal dichalcogenide.
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
A new class of weakly coordinating anions (WCA) based on silicates is disclosed. Facile tuning of sterics and solubility of the disclosed WCA may be achieved via variation of R groups. The anions support a range of cations employed in chemical reactivity, including ether-free alkali cations, Ag+, Ph3C+, Fc+, [NiI(COD)2]+. In one aspect, [Pd(dppe)(NCMe)Me]+ may be generated by salt metathesis or protonation of a metal-alkyl bond, showcasing the ability of the anions to support applications in coordination chemistry and catalysis. Electrochemical studies on the [Bu4N]+ variant show an exceptionally wide stability window for the MeSiF24− anion of 7.5 V in MeCN. CV experiments demonstrate reversible Mg deposition and stripping.
This disclosure provides HIV immunogens and use thereof for generating an immune response in a subject. Also disclosed is a method of isolating anti-HIV antibodies and use thereof. This disclosure further provides a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject using the disclosed HIV immunogens and/or antibodies.
On-chip generation of coherent radiation, i.e. laser-like radiation, can be tuned over broad and/or hard-to-access wavelength regions in an integrated platform. Target spectral coverage is beyond what could be achieved with existing integrated laser systems.
Techniques for monitoring cerebral blood metrics such as cerebral blood flow, cerebral blood volume and/or heart rate are provided. In some embodiments, techniques involve a headset with at least one laser configured to emit light into the brain and one or more light detectors such as CMOS sensors that generate information indicative of light reflected from one or more structures within the brain, which can be used to determine the cerebral blood metrics. Each light detector may be positioned within 5 mm of the scalp in some cases.
Techniques for determining stroke risk are provided. In some embodiments, the techniques may involve causing, using one or more light sources disposed on a headset worn by a user, light to be emitted into the head of the user. The techniques may involve obtaining, using one or more light detectors disposed on the headset, information indicative of light reflected from one more structures within the head, wherein a portion of the obtained information spans a time period during which the user was holding their breath. The techniques may involve based on the obtained information, determining one or more cerebral blood metrics. The techniques may involve providing a representation of the one or more cerebral blood metrics as input to a trained machine learning model, and determining a likelihood the user will experience a stroke over a predetermined future time period based on an output of the trained machine learning model.
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
Techniques for monitoring cerebral blood metrics such as cerebral blood flow, cerebral blood volume and/or heart rate are provided. In some embodiments, techniques involve a headset with at least one laser configured to emit light into the brain and one or more light detectors such as CMOS sensors that generate information indicative of light reflected from one or more structures within the brain, which can be used to determine the cerebral blood metrics. Each light detector may be positioned within 5mm of the scalp in some cases.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
Techniques for determining stroke risk are provided. In some embodiments, the techniques may involve causing, using one or more light sources disposed on a headset worn by a user, light to be emitted into the head of the user. The techniques may involve obtaining, using one or more light detectors disposed on the headset, information indicative of light reflected from one more structures within the head, wherein a portion of the obtained information spans a time period during which the user was holding their breath. The techniques may involve based on the obtained information, determining one or more cerebral blood metrics. The techniques may involve providing a representation of the one or more cerebral blood metrics as input to a trained machine learning model, and determining a likelihood the user will experience a stroke over a predetermined future time period based on an output of the trained machine learning model.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
49.
LIQUID ACCOMMODATING INTRAOCULAR LENS WITH AN ASYMMETRIC CHAMBER
An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.
An apparatus including a source of electromagnetic radiation comprising one or more first frequencies; a source of an input signal comprising an alternating (AC) electric field comprising one or more second frequencies; a control circuit synchronizing application of the electromagnetic radiation and the AC electric field applied to a sample, so that an output signal comprising a modulation of the AC electric field is outputted from the sample in response to (1) the one or more second frequencies tuned to drive hopping of ions between ion sites in the sample, and the one or more first frequencies tuned to drive excitations in the sample that interact with the ions. The apparatus further includes a detection system measuring and/or detecting a change in the output signal in response to the electromagnetic radiation; and a computer determining at least one of a conductivity or impedance of the sample from the output signal and as a function of the first frequencies and the second frequencies.
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
51.
Liquid Accommodating Intraocular Lens with Suspended Central Lens
An intraocular lens (IOL) has a small, central lens suspended within a pliable housing and, when the housing is filled with liquid, is coaxially aligned with a second small lens embedded in the wall of the housing. The suspension is on a dome- or other-shaped webbing attached to an inner circumference of the wall. When filled with liquid, forces squeezing or pulling the equator of the housing, as with ciliary muscles in the eye, adjust a distance between the lenses in order to adjust focus. Optional haptics may project from points on or above and below the equator. A recess in the posterior hemisphere of the housing can keep cell growth away from an optical axis of the lens system. A third small lens can be embedded in an opposite wall of the housing and coaxially aligned with the other lenses to form a three-lens, ultra-zoom system.
An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.
Methods and systems for the electrochemical epoxidation of alkenes to generate an epoxide are described herein. Said methods and systems comprise: contacting an anode comprising an oxygen atom transfer electrocatalyst with an alkene in the presence of an electrolyte comprising water; applying a voltage to the anode and a cathode to generate the epoxide; wherein the oxygen atom transfer electrocatalyst comprises an at least partially oxidized palladium-platinum alloy characterized by the formula FX1: PdyPtzOx; wherein y is greater than 0 and less than 1; z is greater than 0 and less than 1; wherein the sum of y and z is equal to 1; and x is selected from the range of 0 to 2. The methods and systems disclosed herein comprise a significant advancement in the electrocatalytic epoxidation of alkenes in aqueous and mixed electrolytes using water as the oxygen atom transfer source.
C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound
54.
PALLADIUM-PLATINUM OXIDE CATALYST FOR AQUEOUS ELECTROCHEMICAL DIRECT EPOXIDATION
yzxx; wherein y is greater than 0 and less than 1; z is greater than 0 and less than 1; wherein the sum of y and z is equal to 1; and x is selected from the range of 0 to 2. The methods and systems disclosed herein comprise a significant advancement in the electrocatalytic epoxidation of alkenes in aqueous and mixed electrolytes using water as the oxygen atom transfer source.
C25B 11/097 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds comprising two or more noble metals or noble metal alloys
The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
56.
AUXILIARY GYROSCOPE APPROACH FOR BALANCED PERFORMANCE VIA GYRO SELF-CALIBRATION
Methods and devices for bias gyroscopes self-calibration are disclosed. The described teachings can be applied to inertial measurement units implementing one or more auxiliary Coriolis Vibratory Gyroscope (CVG) in conjunction with one or more primary gyroscopes. The auxiliary CVG, capable of mode-switching, enables continuous bias estimation for both its own operation and those of the primary gyroscopes without relying on external aiding sensors. The disclosed methods implement a Kalman filter for bias estimation and can update estimates either at every measurement time step or at mode switching intervals. By combining the good noise performance of primary gyroscopes with the bias stability improvement from the auxiliary CVG, an enhanced overall performance can be achieved.
Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.
An intraocular lens (IOL) has a small, central lens suspended within a pliable housing and, when the housing is filled with liquid, is coaxially aligned with a second small lens embedded in the wall of the housing. The suspension is on a dome- or other-shaped webbing attached to an inner circumference of the wall. When filled with liquid, forces squeezing or pulling the equator of the housing, as with ciliary muscles in the eye, adjust a distance between the lenses in order to adjust focus. Optional haptics may project from points on or above and below the equator. A recess in the posterior hemisphere of the housing can keep cell growth away from an optical axis of the lens system. A third small lens can be embedded in an opposite wall of the housing and coaxially aligned with the other lenses to form a three-lens, ultra-zoom system.
A method for etching a surface including obtaining a substrate comprising a material; reacting a surface of a substrate with a reactant, comprising a gas or a plasma, to form a reactive layer on the substrate, the reactive layer comprising a chemical compound including the reactant and the material; and wet etching or dissolving the reactive layer with a liquid wet etchant of solvent that selectively etches or dissolves the reactive layer but not the substrate.
H01L 21/67 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components
H01L 21/677 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for conveying, e.g. between different work stations
60.
CLEAVE AND RESCUE GAMETE KILLERS FOR GENE DRIVE IN PLANTS
Described herein are embodiments relating to manipulation of the composition, numbers and sex ratio in plant populations through DNA sequence modifications.
Described herein are embodiments relating to manipulation of the composition, numbers and sex ratio in plant populations through DNA sequence modifications.
Lithium niobate (LiNbO3, LN) is a ferroelectric crystal of interest for integrated photonics owing to its large second-order optical nonlinearity and the ability to impart periodic poling via an external electric field. However, on-chip device performance based on thin-film lithium niobate (TFLN) is presently limited by propagation losses arising from surface roughness on the nano- and microscale. Atomic layer etching (ALE) can smooth these features and thereby increase photonic performance. In one embodiment disclosed herein, an isotropic ALE process for x-cut MgO-doped LN uses sequential exposures of H2 and SF6/Ar plasmas. We observed an etch rate of 1.59±0.02 nm/cycle with a synergy of 96.9%. ALE can be achieved with SF6/O2 or Cl2/BCl3 plasma exposures in place of the SF6/Ar plasma step with synergies of 99.5% and 91.5% respectively. The process decreased the sidewall surface roughness of TFLN waveguides etched by physical Ar+ milling by 30% without additional wet processing.
H10N 30/082 - Shaping or machining of piezoelectric or electrostrictive bodies by etching, e.g. lithography
H01L 21/67 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components
63.
Systems and Methods for Communicating by Modulating Data on Zeros in the Presence of Channel Impairments
Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol remitting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.
Bistable devices are constructed using a polynucleotide platform for the sensing of molecular events such as binding or conformational changes of target molecules. Uses include measurement of target concentration, measuring the effect of environmental condition (such as heat, light, or pH) on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices comprise three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Devices carry DNA tags to enable separation of open and closed devices, as well as barcoding for multiplexed detection.
The present invention relates to broadly neutralizing anti-HIV-1 antibodies and isolated antigens. Also disclosed are related methods and compositions.
In many embodiments of the invention, a space-based data center includes orbital server modules configured to be deployed in space, each module including a communication subsystem for module-to-module communications to form a data center, tiles arranged in a planar array, where each tile has a layered structure including solar cells forming a layer across a first surface, thermal radiator panels forming a layer across a second surface, electronic components distributed laterally in a layer between the layer of solar cells and the layer of thermal radiator panels, where each electronic component receives power locally from solar cells and rejects heat to the thermal radiator panel beneath it, where a first subset of tiles are compute tiles in which the electronic components include one or more computing processors and memory, and where a second subset of tiles are support tiles in which the electronics components include network switches and energy storage.
Disclosed herein include methods, compositions, and kits suitable for use in tuned dosage-invariant expression of a payload protein. Compositions (e.g., nucleic acid compositions, one or more cells) provided herein can comprise a first promoter sequence operably linked to a first polynucleotide comprising one or more miRNA cassettes, and a second promoter sequence operably linked to a second polynucleotide comprising a payload gene. In some embodiments, the first promoter sequence is capable of inducing transcription of the first polynucleotide to generate a first transcript, and the first transcript is capable of being processed to generate said miRNA. The payload gene can comprise a miRNA target region comprising one or more miRNA target sequences.
A circuit comprising a first Fourier Transform block operable to perform a Fourier Transform and having a first input configured for receiving an I signal and a second input configured for receiving a Q signal; a first plurality of n of outputs for I channels and Q channels each comprising a different frequency bin output from the Fourier Transform; I and Q summing blocks comprising a set of connector lines connecting an ith one of I channels with an ith one of the Q channels; an inverse Fourier Transform block connected to the summing blocks and operable to perform an inverse Fourier Transform; a correlator for correlating the outputs of the inverse Fourier Transform; a Fourier Transform block for Fourier Transforming the correlator output; a comparator for comparing the correlation term to zero; and an error correction circuit for tuning the magnitude and phase of the I and Q channels using the comparator output as feedback.
Devices for the assembly of structures are described. More specifically, devices designed for the assembly of structures in space are described, with a particular focus on antenna structures and methods for their assembly and deployment in space. Even more specifically, it addresses the construction of mesh reflector antennas in space. The invention includes devices, systems, and methods designed to facilitate the creation and deployment of these antennas in a space environment by leveraging advanced assembly techniques.
Disclosed herein are analogs and derivatives of aleutianamine and methods of making the same. Also disclosed herein are methods of treating pancreatic cancer comprising administration of aleutianamine or its analogs.
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
Disclosed herein include methods, compositions, and kits suitable for use in tuned dosage-invariant expression of a payload protein. Compositions (e.g., nucleic acid compositions, one or more cells) provided herein can comprise a first promoter sequence operably linked to a first polynucleotide comprising one or more miRNA cassettes, and a second promoter sequence operably linked to a second polynucleotide comprising a payload gene. In some embodiments, the first promoter sequence is capable of inducing transcription of the first polynucleotide to generate a first transcript, and the first transcript is capable of being processed to generate said miRNA. The payload gene can comprise a miRNA target region comprising one or more miRNA target sequences.
Described herein are compositions having an eight-membered monocyclic unsaturated hydrocarbon, methods and system to separate the eight-membered monocyclic unsaturated hydrocarbon at from a hydrocarbon mixture including additional nonlinear unsaturated C8H2m hydrocarbons with 4≤m≤8, by contacting the hydrocarbon mixture with a 10-ring pore molecular sieve having a sieving channel with a 10-ring sieving aperture with a minimum crystallographic free diameter greater than 3 Å and a ratio of the maximum crystallographic free diameter to the minimum crystallographic free diameter between 1 and 2, the molecular sieve having a T1/T2 ratio ≥20:1 wherein T1 is an element independently selected from Si and Ge, and T2 is an element independently selected from Al, B and Ga, the 10-ring pore molecular sieve further having a counterion selected from NH4+, Li+, Na+, K+ and Ca++.
C07C 7/13 - Purification, separation or stabilisation of hydrocarbonsUse of additives by adsorption, i.e. purification or separation of hydrocarbons with the aid of solids, e.g. with ion-exchangers by molecular-sieve technique
C07C 13/263 - Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with an eight-membered ring with a cyclo-octene or cyclo-octadiene ring
C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
73.
OPTICAL FIBER-BASED TSUNAMI WARNING SYSTEM USING SUBMARINE TELECOMMUNICATION CABLES
The invention describes a tsunami warning system utilizing properties of light in optical fibers within submarine telecommunication cables. Enhanced by microwave frequency modulation and High-Loss Loop Back (HLLB) techniques, this system measures photoelastic changes for more stable, long-period tsunami wave detection.
G01L 11/02 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by means not provided for in group or by optical means
G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
G01V 1/38 - SeismologySeismic or acoustic prospecting or detecting specially adapted for water-covered areas
G01H 9/00 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by using radiation-sensitive means, e.g. optical means
Hyper-Heisenberg scaling quantum imaging techniques that pass an idler photon of each entangled photon pair three times through an idler objective pair and pass a signal photon of each entangled photon pair at least once through a signal objective pair and use measurements of coincidence detection to yield a coincidence image with spatial resolution of about four times that of classical imaging.
The present invention relates to methods of treating breast cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein. In some embodiments the subject can be receiving chemotherapy with a conventional chemotherapy drug and/or a therapeutic monoclonal antibody or drug conjugate thereof.
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/7072 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
C07H 1/00 - Processes for the preparation of sugar derivatives
An on-chip pulse synthesizer including an integrated photonic chip that temporally and spectrally shapes pulses of light using primarily quadratic optical nonlinearities. Through this synthesis, the light pulses undergo temporal shortening or reshaping, spectral broadening, wavelength conversion, or a combination thereof. A key aspect of this synthesis is the mode engineering of the waveguides, which includes converting the pump source mode to the relevant mode in the nonlinear optical region and tailoring the waveguide geometry and material stack to enable dispersion-engineering as well as engineering of the phase matching for various nonlinear processes.
G02F 1/365 - Non-linear optics in an optical waveguide structure
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves
77.
METHOD FOR TRANSFERRING A PRESSURE WAVE FROM PERIPHERAL SITE TO CENTRAL SITE
The disclosure relates to techniques for transferring a pulse pressure waveform signal of a peripheral vascular site to a central vascular site. In some implementations, a method includes: obtaining a time-domain representation of a first pulse pressure waveform signal of a brachial artery of a subject; converting the time-domain representation of the first pulse pressure waveform signal to a frequency-domain representation of the first pulse pressure waveform signal; selecting a first plurality of frequency components of the frequency-domain representation of the first pulse pressure waveform signal; predicting, using a non-linear mapping, based on the first plurality of frequency components, a second plurality of frequency components of a frequency-domain representation of a second pulse pressure waveform signal of an ascending aorta or left ventricle of the subject; and converting the frequency-domain representation of the second pulse pressure waveform signal to a time-domain representation of the second pulse pressure waveform signal.
The invention describes a tsunami warning system utilizing properties of light in optical fibers within submarine telecommunication cables. Enhanced by microwave frequency modulation and High-Loss Loop Back (HLLB) techniques, this system measures photoelastic changes for more stable, long-period tsunami wave detection.
This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
G06F 17/11 - Complex mathematical operations for solving equations
G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
G16B 25/00 - ICT specially adapted for hybridisationICT specially adapted for gene or protein expression
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G16B 40/10 - Signal processing, e.g. from mass spectrometry [MS] or from PCR
80.
COMPOSITIONS FOR TRANSPORT OF THERAPEUTIC CARGOS USING ANTIBODY BINDERS TARGETING CA-IV
The present invention provides compositions and methods comprising antibodies as shuttles for the BBB-crossing, for example through the receptor carbonic anhydrase IV (CA-IV).
A61K 47/66 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
A61P 25/00 - Drugs for disorders of the nervous system
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
The present invention provides compositions and methods comprising brinzolamide and brinzolamide derivates as shuttles for the BBB-crossing, for example through the receptor carbonic anhydrase IV (CA-IV).
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
82.
COMPOSITIONS FOR TRANSPORT OF THERAPEUTIC CARGOS USING MINIPROTEIN BINDERS TARGETING CA-IV
The present invention provides compositions and methods comprising miniproteins as shuttles inducing transcytosis across target tissues, for example through an astrocyte-specific receptor, neuron-specific receptor, carbonic anhydrase IV (CA-IV), low density lipoprotein receptor related protein 6 (LRP6), or lymphocyte antigen 6 complex, locus A (LY6A).
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Disclosed herein include methods, compositions, and kits suitable for use in capturing lineage relationships in dividing cell populations. Disclosed herein include compact phylogenetic recording systems for high resolution lineage reconstruction over long time scales. In some embodiments, the system comprises one or more hypercascade array(s) each comprising p hypercascade units, n layer guide RNAs, and an editor. In some embodiments, the system comprises one or more target array(s) comprising n editable target sites, n guide RNAs gRNAs, and a base editor capable of adenine (A)-to-guanine (G) base editing.
Imaging methods and apparatus for localizing biopsy needles coupled to an ultrasonic transmitter and/or monitoring ablation of an ablation probe connected to a microwave source, which include an arbitrary waveform generator for generating a chirp signal that excites the ultrasonic transmitter to generate an ultrasonic signal or modulates the microwave signal.
Systems and methods for a wearable system that monitors various biomarkers with a 3D-printed wearable electronic skin. Specifically, the wearable system is a 3D-printed epidermal wearable microfluidic electronic skin that may be composed of a combination of multidimensional nanomaterials, polymers, and hydrogels. The epidermal wearable microfluidic electronic skin may be integrated with sensors, electrodes, microfluidics, and a processor to collect and analyze molecular biomarkers of biofluid samples on the user's skin, while simultaneously analyzing the user's physiological biomarkers to conduct a health status assessment or gather health monitoring/surveillance metric.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
Methods and systems are described of a stochastic quantitative approach (StochQuant) that uses molecular counts obtained from a testing measurement, an absolute anchoring measurement of a reference molecule, and possibly additional physical parameters such as quantitatively measurable amounts of a sample, to identify a probability distribution, a confidence interval and/or a confidence level in outcome of a testing measurement of a target molecule, thus improving reliability and accuracy of quantitative detection of the target molecule performed by the testing measurement.
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
87.
3D-Printed Epidermal Wearable Microfluidic Electronic Skin for Machine Learning-Powered Multimodal Health Surveillance
Systems and methods for a wearable system that monitors various biomarkers with a 3D-printed wearable electronic skin. Specifically, the wearable system is a 3D-printed epidermal wearable microfluidic electronic skin that may be composed of a combination of multidimensional nanomaterials, polymers, and hydrogels. The epidermal wearable microfluidic electronic skin may be integrated with sensors, electrodes, microfluidics, and a processor to collect and analyze molecular biomarkers of biofluid samples on the user's skin, while simultaneously analyzing the user's physiological biomarkers to conduct a health status assessment or gather health monitoring/surveillance metric.
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition.
Provided herein are methods and systems and related devices and compositions for electrochemical control of viability of redox active bacteria. The electrochemical control is performed by applying to a working electrode contacting a medium known or suspected to comprise the redox active bacteria, a reducing potential which is lower of the midpoint potential of a redox active compound produced by the redox active bacteria.
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
Disclosed herein is a composition for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples. Also disclosed herein, is a kit for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples. Also disclosed herein, is a method for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples.
In some embodiments, methods of inhibiting, ameliorating, reducing the severity of, treating, reducing the likelihood of, or preventing social isolation stress or symptoms thereof in a subject in need thereof are described. In some embodiments, methods of determining a risk of social isolation stress in a subject are described.
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61P 43/00 - Drugs for specific purposes, not provided for in groups
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
This present disclosure provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The present disclosure also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
C12Q 1/6837 - Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
TIMED AND/OR TARGETED CHLORATE ADMINISTRATION, AND RELATED MATRICES, COMPOSITIONS, IMPLANTS, METHODS AND SYSTEMS FOR PREVENTION AND/OR TREATMENT OF INFECTIONS
Methods and systems and related compositions, matrices and devices, for timed and/or targeted administration of chlorate for treatment and/or prevention of infections of a biological environment and related compositions, devices, matrices and implants. Chlorate administration can be performed alone or in combination with an antibiotic in a location and/or time targeted manner, the concentration and use of the chlorate and/or the antibiotic agents depending on the oxic/hypoxic/anoxic condition of the area being treated.
The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci.
A system and method for joint dynamic interest request forwarding and dynamic cache placement and eviction and provided within the context of the Named Data Networking (NDN) architecture. The system and method employ a virtual control plane that operates on the user demand rate for data objects in the network, and an actual plane that handles Interest Packets and Data Packets. Distributed algorithms within the virtual plane achieve network load balancing through dynamic forwarding and caching, thereby maximizing the user demand rate that the NDN network can satisfy. A method of congestion control is also provided to achieve optimal network fairness using the VIP framework.
Disclosed herein arc methods that can be used to improve, treat and/or inhibit neurodevelopmental disorders in subjects in need, for example subjects suffering from Parkinson's disease. Some embodiments include administering an effective amount of fecal microbiota to the subject in need thereof, wherein the fecal microbiota is derived from healthy donors who are younger in age as compared to the subjects suffering from Parkinson's disease. Upon treatment, one or more symptoms of neurodevelopmental disorders can be improved in the subject.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
G01N 33/554 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
97.
MINIMAL STATE AUGMENTATION ALGORITHM FOR STEREO-VISION-BASED NAVIGATION
A method to perform vision based navigation on a moving vehicle. An image processor receives reference images with associated depth information as base frames or search frames. 2D features are detected in base frames and tracked in subsequent search frames. A new base frame is triggered when a number of features or a spatial distribution fall under thresholds. A depth processor reconstructs the depth and 3D position of each of the 2D features. A track manager manages a feature list database mapping the 2D coordinates of each tracked 2D feature with the 3D coordinate of that feature. A state manager constructs a filter state vector with 15 error states propagated at an IMU rate and 6 additional error states corresponding to clones of pose states. A visual updater utilizes the tracked 2D feature coordinates to update the filter state vector. A filter forms residuals and corrects inertial error drift.
G01C 21/28 - NavigationNavigational instruments not provided for in groups specially adapted for navigation in a road network with correlation of data from several navigational instruments
G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
G06T 7/593 - Depth or shape recovery from multiple images from stereo images
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
98.
INVERTING EARTHQUAKE FOCAL MECHANISMS WITH DISTRIBUTED ACOUSTIC SENSING
The present invention infers the first-motion polarities using the relative polarities measured from cross-correlations. We demonstrate two real-world applications on two DAS arrays in the manuscript to illustrate the effectiveness of our method and improvements to the focal mechanism inversion.
G01V 1/22 - Transmitting seismic signals to recording or processing apparatus
E21B 41/00 - Equipment or details not covered by groups
G01D 5/353 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells influencing the transmission properties of an optical fibre
Disclosed herein include methods, compositions, and kits suitable for use in the measurement of the states of living cells across time and for use in the delivery of polyribonucleotides and circuits. There are provided, in some embodiments, RNA exporter proteins comprising an RNA-binding domain, a membrane-binding domain, and an interaction domain capable of nucleating self-assembly. Disclosed herein include polynucleotides encoding reporter RNA molecule(s) or cargo RNA molecule(s). In some embodiments, a plurality of RNA exporter proteins are capable of self-assembling into lipid-enveloped nanoparticles (LNs) secreted from a cell in which the RNA exporter proteins are expressed, thereby generating a population of LNs comprising exported reporter RNA molecule(s) or a fusogen and exported cargo RNA molecule(s). Disclosed herein include export modulator proteins capable of, e.g., enhancing or suppressing LN export.
Disclosed herein are methods that can be used to improve, treat and/or inhibit neurodevelopmental disorders in subjects in need, for example subjects suffering from Parkinson's disease. Some embodiments include administering an effective amount of fecal microbiota to the subject in need thereof, wherein the fecal microbiota is derived from healthy donors who are younger in age as compared to the subjects suffering from Parkinson's disease. Upon treatment, one or more symptoms of neurodevelopmental disorders can be improved in the subject.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
