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Résultats pour
 brevets
1.
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HYDRAZIDOMYCINS
| Numéro d'application |
EP2012002203 |
| Numéro de publication |
2012/159751 |
| Statut |
Délivré - en vigueur |
| Date de dépôt |
2012-05-23 |
| Date de publication |
2012-11-29 |
| Propriétaire |
- ONCOTEST GMBH (Allemagne)
- LEIBNIZ - INSTITUT FÜR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE (Allemagne)
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| Inventeur(s) |
- Fiebig, Heinz Herbert
- Kelter, Gerhard
- Maier, Armin
- Ueberschaar, Nico
- Tchize Ndejounong, Basile Le Sage
- Ding, Ling
- Hertweck, Christian
- Meyer, Florian
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Abrégé
The present invention relates to pharmaceutical formulations comprising specific hydrazidomycin compounds. Since said hydrazidomycin compounds show cytotoxic activities, the present invention further relates to said hydrazidomycin compounds for use in medicine, in particular in the treatment of proliferative disorders.
Classes IPC ?
- A61K 31/16 - Amides, p. ex. acides hydroxamiques
- C07C 243/30 - Hydrazines ayant des atomes d'azote de groupes hydrazine acylés par des acides carboxyliques avec des groupes carboxyle acylants liés à des atomes d'hydrogène ou à des atomes de carbone acycliques à des atomes de carbone d'un squelette carboné non saturé
- A61P 35/00 - Agents anticancéreux
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2.
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DI PEPTIDE DERIVATIVE FOR THE TREATMENT OF CANCER
| Numéro d'application |
IB2011053502 |
| Numéro de publication |
2012/020364 |
| Statut |
Délivré - en vigueur |
| Date de dépôt |
2011-08-05 |
| Date de publication |
2012-02-16 |
| Propriétaire |
- PIRAMAL ENTERPRISES LIMITED (Inde)
- ONCOTEST GMBH (Allemagne)
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| Inventeur(s) |
- Deshmukh, Sunil Kumar Jaiwant Rao
- Verekar, Shilpa Amit
- Mishra, Prabhu Dutt
- Eyyammadichiyil, Sreekumar Sankaranarayanan
- Joshi, Kalpana Sanjay
- Fiebig, Heinz-Herbert
- Kelter, Gerhard
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Abrégé
This invention relates to purified compound of formula (1). The invention includes all isomeric forms and all tautomeric forms of the compound of formula (1) and pharmaceutically acceptable salts thereof. The present invention further relates to processes for the production of the compound of formula (1) by fermentation of the fungal strain of sterile mycelium (PM0509732/MTCC5544) and to pharmaceutical compositions containing the compound as active ingredient and its use in medicines for treatment of cancer.
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3.
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MACROCYCLIC LACTONE DERIVATIVES FOR THE TREATMENT OF CANCER
| Numéro d'application |
IB2010055161 |
| Numéro de publication |
2011/061666 |
| Statut |
Délivré - en vigueur |
| Date de dépôt |
2010-11-15 |
| Date de publication |
2011-05-26 |
| Propriétaire |
- PIRAMAL LIFE SCIENCES LIMITED (Inde)
- ONCOTEST GMBH (Allemagne)
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| Inventeur(s) |
- Mohammed Abdul, Shafee
- Mishra, Prabhu Dutt
- Vishwakarma, Ram
- Fiebig, Heinz-Herbert
- Kelter, Gerhard
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Abrégé
The present invention provides compounds represented by formula (1): wherein, R1, R2, R3 and R4 are as defined in the specification, in all their stereoisomeric and tautomeric forms and mixtures thereof in all ratios, and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable polymorphs and prodrugs. The invention also relates to processes for the manufacture of compounds of formula (1) and pharmaceutical compositions containing them. The compounds and the pharmaceutical compositions of the present invention are useful for the treatment of cancer. The present invention further provides a method of treatment of cancer by administering a therapeutically effective amount of the said compound of formula (1) or its pharmaceutical composition, to a mammal in need thereof.
Classes IPC ?
- C07D 313/00 - Composés hétérocycliques contenant des cycles de plus de six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle
- A61K 31/365 - Lactones
- A61P 35/00 - Agents anticancéreux
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