Methods of depositing high-quality conformal silicon oxycarbonitride (SiOCN) films in the formation of semiconductor devices are described. The methods include a first deposition cycle comprising exposing a semiconductor substrate in a semiconductor processing chamber to a first precursor, a first purge gas, a second precursor, and a second purge gas to deposit a conformal silicon carbonitride (SiCN) film, wherein the first precursor is a silicon- and carbon-containing precursor, and the second precursor comprises one or more of ammonia (NH3), a diamine (NH2—R—NH2 wherein R is an alkyl group), hydrazine (N2H4), and diazene (N2H2). The conformal silicon carbonitride (SiCN) film is then oxidized to form a conformal silicon oxycarbonitride (SiOCN) film, and the conformal silicon oxycarbonitride (SiOCN) film is thermally annealed to form a high-quality conformal silicon oxycarbonitride (SiOCN) film.
Disclosed is a method of generating midbrain dopamine progenitors (mDAPs) from human pluripotent stem cells (hPSCs), comprising: (a) treating hPSCs with a Wnt agonist and a Wnt antagonist, to generate midbrain floor plate progenitors (mFPPs); (b) treating the mFPPs with Activin A and a sonic hedgehog (SHH) agonist to restrict the mFPPs to medial mFPPs; and (c) removing the SHH agonist and adding the Wnt agonist to differentiate medial mFPPs to mDAPs. Also disclosed is a plurality of midbrain dopamine progenitors (mDAPs) or midbrain dopamine neurons (mDANs) generated by the method as disclosed herein, and a pharmaceutical composition comprising the plurality of mDAPs. Further disclosed is a method of treating a neurological disease of a subject, comprising administering the plurality of mDAPs or the pharmaceutical composition as disclosed herein into a neurological disease site of the subject.
Agents capable of inhibiting interleukin 7 receptor (IL-7R)-mediated signalling and their use in methods of treating or preventing diseases or conditions characterised by fibrosis and/or inflammation are disclosed herein.
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
4.
METHODS OF FORMING CONFORMAL SILICON OXYCARBONITRIDE THIN FILMS ON HIGH ASPECT RATIO SEMICONDUCTOR STRUCTURES
32224222). The conformal silicon carbonitride (SiCN) film is then oxidized to form a conformal silicon oxycarbonitride (SiOCN) film, and the conformal silicon oxycarbonitride (SiOCN) film is thermally annealed to form a high-quality conformal silicon oxycarbonitride (SiOCN) film.
A sensor for detecting a target polynucleotide is described. In an embodiment, the sensor comprising: at least one oligonucleotide probe, wherein the at least one oligonucleotide probe comprises a target-specific oligonucleotide complementary to a portion of the target polynucleotide, a shorter oligonucleotide anchored to an electrode, one end portion of the target-specific oligonucleotide is complementary to, and forms a duplex with, the shorter oligonucleotide, and a redox molecule attached to the target- specific oligonucleotide, wherein the target-specific oligonucleotide destabilises upon binding to the portion of the target polynucleotide and is released from the shorter oligonucleotide anchored to the electrode, modulating a distance between the redox molecule and a surface of the electrode to cause a change in electrochemical potential detected by the electrode for detecting the target polynucleotide. Embodiments in relation to a sensing platform, system and method for detecting a target polynucleotide are also described.
C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
6.
APTAMERS AND RIBOSWITCHES OF LUTEOLIN AND OTHER NARINGENIN DERIVED FLAVONOIDS FOR IN VITRO AND IN VIVO SENSING
Disclosed is an aptamer capable of binding to luteolin and other naringenin derived flavonoids, wherein the aptamer is: an RNA aptamer having a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO: 2; or a DNA aptamer having a nucleotide sequence selected from the group consisting of SEQ ID NO: 3 and SEQ ID NO: 4; wherein for SEQ ID NO: 1 and 2, N is one nucleotide selected from the group consisting of A, G, C and U, and wherein for SEQ ID NO: 3 and 4, N is one nucleotide selected from the group consisting of A, G, C and T. Also disclosed is a riboswitch and a DNA expression cassette comprising the aptamer, a composition thereof, and a microbe containing the riboswitch or DNA expression cassette. Further disclosed is a method of detecting luteolin and other naringenin derived flavonoids produced in a microbe using the aptamer or riboswitch as disclosed herein.
This disclosure concerns compositions and methods for replicating DNA containing a T7 origin of replication (T7 or/). Compositions and methods herein use a set of proteins that includes a DNA polymerase (DNAP), an RNA polymerase (RNAP), a single-strand binding protein (SSBP) and a helicase-primase (HP), along with one or more linearising proteins and linearising protein-binding nucleic acid sequences to maintain the replicated DNA in a linear conformation. In one example, the addition of a protelomerase recognition sequence (TeIRL) as the linearising protein-binding nucleic acid sequence to a T7 or/ plasmid, in combination with the use of a protelomerase (TelN) as the linearising protein during DNA replication, enabled linearisation, replication and maintenance of a T7 or/ plasmid in E. coli. The DNAP may be a mutagenic polymerase, so that methods herein may also be used for DNA mutagenesis and evolution of target DNA sequences.
NATIONAL UNIVERSITY OF SINGAPORE CHONGQING RESEARCH INSTITUTE (Chine)
Inventeur(s)
Teo, Chung Piaw
Liu, Changchun
Liu, Ju
Abrégé
Disclosed is a method for generating tickets, such as lottery tickets, to approximate an unknown reference ticket, e.g., winning numbers. After receiving a request for tickets, seed tickets are acquired that bear random numbers from a set of numbers. The seed tickets are generated using a mixed-integer programming model that ensures a near-identical pairwise similarity measure among the tickets while minimising total similarity measures for all pairs by uniformly distributing the numbers. The tickets are generated from the seed ticket using a one-to-one number mapping module, by replacing numbers from respective seed tickets with other ones of the numbers, to maintain identical structure between generated tickets and seed tickets, and avoid repetition between the tickets and further tickets that have previously been issued in response to respective further requests for tickets.
G06F 7/58 - Générateurs de nombres aléatoires ou pseudo-aléatoires
G06F 17/12 - Opérations mathématiques complexes pour la résolution d'équations d'équations simultanées
G07F 17/32 - Appareils déclenchés par pièces de monnaie pour la location d'articlesInstallations ou services déclenchés par pièces de monnaie pour jeux, jouets, sports ou distractions
9.
A MOLECULAR MOTOR AND AN OPTICAL METHOD OF CONTROLLING
The invention relates to a molecular motor and a method of driving the molecular motor step-by-step on a track under bi-colour light irradiations. The molecular motor comprising a hairpin leg and a non-hairpin leg. The molecular motor can be instructed to move to specific states or positions on the track by illumination of alternate lights, such as ultraviolet light and visible light, presenting a translational molecular motor with capability of top-down control by selecting the irradiation wavelengths.
C07H 21/00 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques
B82B 1/00 - Nanostructures formées par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles
B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
10.
HEATRICH-BS: HEAT ENRICHMENT OF CPG-RICH REGIONS FOR BISULFITE SEQUENCING
The present invention is directed to a method using heat denaturation of DNA fragments having low GC content to enrich for CpG regions that can be enriched by adapter-ligation, subjected to bisulfite conversion, sequenced and analysed, for example, to detect cancer.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p. ex. séquençage par hybridation [SBH]
Agency for Science, Technology and Research (Singapour)
Inventeur(s)
Zhang, Dewen
Yuan, Zifeng
Danner, Aaron James
Lim, Soon Thor
Hoang, Thanh Xuan
Abrégé
An optical, programmable Ising machine uses a master laser for injection locking one or both of the optical frequency and polarization state of slave beams from a plurality of slave lasers—the slave lasers represent Ising bits. The slave beams are split into two or more coupling beams. Some of the coupling beams are rotated (e.g., by) 90°, so that the coupling beams can represent both positive and negative coupling terms between the Ising bits. The coupling beams are then combined and directed back into the optical cavities of the slave lasers, to provided optical feedback, to evolve the state of the Ising machine.
This disclosure concerns a method of imparting and/or enhancing an olfactory perception of a meat flavour in a food, comprising a step of adding iron chlorophyllin at about 0.002 %w/w to about 5 %w/w relative to the food, wherein when heated, the iron chlorophyllin is configured to interact with a component in the food in order to generate volatiles which replicate the meat flavour. The disclosure also concerns an iron chlorophyllin composition.
C07D 487/22 - Composés hétérocycliques contenant des atomes d'azote comme uniques hétéro-atomes dans le système condensé, non prévus par les groupes dans lesquels le système condensé contient au moins quatre hétérocycles
This disclosure concerns methods of treating cardiometabolic diseases and conditions, in particular cardiovascular diseases conditions associated with metabolic disorders, using extracellular vesicles derived from milk.
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
14.
INORGANIC MEMBRANES AND METHODS OF FABRICATION THEREOF
This disclosure concerns a method of fabricating an inorganic membrane, comprising coalescing inorganic particles at an air-liquid interface of a vessel in order to form the inorganic membrane, wherein inner walls of the vessel is configured to repel the inorganic nanoparticles.
Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.
C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
C07K 14/715 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des cytokinesRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des lymphokinesRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des interférons
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
The invention provides a gas sensor comprising an optically transparent substrate (100); an array of nanoantennae (200) being disposed on the optically transparent substrate (100); and a metal-organic framework hybridised with a polymer being integrated into the gas sensor; wherein the nanoantennae (200) are configured as dark-bright mode coupling antennae with one or more nanogaps being formed adjacent to one or more hotspots of the nanoantennae (200) in bright mode.
G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
The present invention relates to an itch relief device which comprises a spherical roller having an insert and an external layer overmoulded over the insert, the insert being heavier than the external layer, and a housing. The housing further comprises a cavity for retaining the spherical roller and shaped to prevent displacement of the spherical roller within the housing, and an aperture having a maximum dimension smaller than an outer diameter of the spherical roller, a portion of the spherical roller protruding through the aperture to contact skin of a user, wherein the external layer comprises a plurality of regularly spaced protrusions extending outwardly, away from the insert, and wherein, as the housing is moved over the skin, contact with the skin induces the spherical roller to roll, thereby bringing successive ones of the protrusions against the skin.
A device measures nanoscale displacements of an object positioned in an optical cavity aligned with each dimension sought to be measured. Each optical cavity receives light from a direction corresponding to a respective dimension, and includes an optical absorber for increasing sensitivity of the optical cavity.
G01B 9/02018 - Interféromètres à passages multiples, p. ex. à double passage
G01B 11/14 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la distance ou la marge entre des objets ou des ouvertures espacés
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
Inventeur(s)
Foo, Chuan Yao
Rai, Bina
Manohara, Ruben
Abrégé
This disclosure describes an apparatus for positioning a central guide pin into a glenoid cavity. The apparatus (100,100a,200,200a) is made up of: a base plate (110,210,210a); a handle mountable on the base plate; a plurality of barbs projecting (113,213,213a) from a bottom surface of the base plate; a guide tube (170,270,270a) threadedly connected to a lock tube (180,280,280a), wherein a longitudinal bore (d) extends along longitudinal bores of both the guide tube and lock tube, with the lock tube having an anti-rotation collar (185,285); a first protractor mechanism for adjusting an angle of inclination (α) of the guide tube from a vertical X-axis to the base plate; and a second protractor mechanism with a plane of adjustment being perpendicular to a plane of adjusting the first protractor mechanism, so that trajectory of the central guide pin inserted in through the guide tube (170,270,270a) is defined by these two perpendicular planes.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapour)
Singapore Health Services Pte Ltd (Singapour)
NATIONAL UNIVERSITY OF SINGAPORE (Singapour)
Inventeur(s)
Sabapathy, Tr Kanaga
Lane, David Philip
Hwang, Le-Ann
Koh, Xin Yu
Wah, Liew Oi
Abrégé
The invention relates to methods for producing an antibody which is specific for a mutant p53 polypeptide over wildtype p53 polypeptide, comprising using as an immunogen a peptide or polypeptide comprising: (i) an antigen sequence, comprising an amino acid sequence of the mutant p53 polypeptide including the mutation and at least one amino acid immediately adjacent to the mutation, and (ii) a scaffold sequence for providing the antigen sequence in a solvent-accessible configuration. Also provided are antibodies produced by such methods, and uses thereof.
Various embodiments may relate to a method of forming a two-dimensional (2D) material based structure. The method may include forming a self-assembled monolayer (SAM) on an underlying structure. The method may also include forming a two-dimensional material (2DM) film. The 2DM film may be suspended over the self-assembled monolayer (SAM), the two-dimensional (2DM) film separated from the self-assembled monolayer (SAM) by a solvent or a fluid. The method may further include bringing the two-dimensional material (2DM) film and the self-assembled monolayer (SAM) in contact with each other.
C23C 16/22 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le dépôt de matériaux inorganiques, autres que des matériaux métalliques
C23C 16/06 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le dépôt d'un matériau métallique
Imaging systems and methods are described An imaging system comprises: a pixel array having a plurality of pixels, each pixel comprising a light sensor configured to generate a pixel signal in response to light incident on the pixel; a saliency detection circuit configured to detect salient events from the pixel signals; and a segmentation circuit configured to segment salient pixels by performing erosion and dilation operations on pixels corresponding to the salient events.
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
H04N 25/47 - Capteurs d'images avec sortie d'adresse de pixelCapteurs d'images commandés par événementSélection des pixels à lire en fonction des données d'image
G06T 7/155 - DécoupageDétection de bords impliquant des opérateurs morphologiques
G06T 7/194 - DécoupageDétection de bords impliquant une segmentation premier plan-arrière-plan
The present invention relates generally to health and fitness. In particular, the present invention relates to a computer-implemented method for optimising a health plan to promote health and fitness and/or weight loss in a subject. The health plan involves monitoring the level of glucose and ketone of the subject over a multi-day time period to provide an indication on whether metabolic switch and/or ketosis is achieved in each day of the multi-day period. Also provided are devices and computer program products as defined herein.
G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapour)
Inventeur(s)
Ong, Sin Tiong
Nacro, Kassoum
Chennamaneni, Lohitha Rao
Abrégé
Targeting Metabolic Pathways with MNK Inhibitors The invention belongs to the field of medicine and concerns the treatment of diseases related to aberrant upregulated de novo lipid biosynthesis using a MAPK interacting kinase (MNK) inhibitor, especially for the prophylaxis or treatment of breast cancers, prostate cancers, obesity, atherosclerosis, diabetes mellitus, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, chronic kidney disease, and neurological disorders. An aspect of the invention relates to the use of an MNK inhibitor designated (4-(3-((2- (dimethylamino)pyridin-4-yl)ethynyl)pyrazolo[1,5-a]pyrimidin-5-yl)phenyl)(morpholino) methanone, for the prophylaxis or treatment of triple-negative breast cancer and brain metastases therefrom.
The invention provides a composite material comprising a porous substrate, a polycrystalline material layer disposed on a surface of the porous substrate, wherein the polycrystalline material layer comprises a plurality of intergrown crystals formed from a UiO-66 metal- organic framework (MOF), or derivative thereof and wherein the plurality of intergrown crystals are characterized by a powder X-ray diffractogram with characteristic peaks indicative of reo-structured regions within the UiO-66 MOF, or derivative thereof. The invention also provides a method of preparing the composite material comprising the steps of providing the porous substrate and a reaction mixture comprising an organic solvent, BDC or derivative thereof, a Zr salt, and a Zn salt and immersing the porous substrate in the reaction mixture from step (a) and heating the resulting mixture at a temperature of from about 150 °C to about 250 °C for a period of time to provide the composite material.
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01J 20/22 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance organique
26.
CORE-SHELL NANOPARTICLES AND METHODS OF FABRICATION THEREOF
The present disclosure concerns core-shell nanoparticles, each comprising a core comprising Nb and NbS2; preferably NbS2 and a shell of Formula NbSxOy·zH2O, wherein x is a number from 0 to 5; y is a number from 0 to 3; and z is a number from 0 to 10. The present disclosure also concerns a method of synthesising core-shell nanoparticles.
A1A2A3nB1B2B3A1A2A3B1B2B3A1B1A2B2B3B1B3nn is an amide bond or 1 to 3 amino acid residue; and wherein the polypeptide optionally comprises a further 3-residue motif.
There is provided a method for model-based video compression (MBVC) and data transmission, which includes generating a 3D model of an area of interest based on a first video sequence of the area of interest captured by a camera and a pose of the camera, generating a refined camera pose for a second video sequence of the area of interest, generating a synthesized image of the area of interest based on the generated 3D model of the area of interest and the refined camera pose, comparing the synthesized image with a corresponding image captured by the camera and computing a residual, and transmitting a latent representation of the synthesized image and the residual to a receiving end.
H04N 19/20 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage d'objets vidéo
H04N 7/12 - Systèmes dans lesquels le signal de télévision est transmis par un canal ou une pluralité de canaux parallèles, la bande passante de chaque canal étant inférieure à la largeur de bande du signal de télévision
B63C 11/52 - Outillage spécialement adapté au travail sous l'eau, non prévu ailleurs
The present disclosure provides a lipid nanoparticle comprising a helper lipid at about 5 mol% to about 80 mol% relative to a total lipid content; an ionisable lipid at about 20 mol% to about 95 mol% relative to the total lipid content; a conjugated oligoelectrolyte at about 0.005 mol% to about 5 mol% relative to the total lipid content, wherein the conjugated oligoelectrolyte is configured to interact with at least the helper lipid in order 10 to stabilise the lipid nanoparticle. The present disclosure also provides methods of fabricating the lipid nanoparticle and methods of use thereof.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
30.
A SYSTEM AND METHOD FOR DETERMINING A TREATMENT TO BE APPLIED TO THE BRAIN
QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE (Australie)
Inventeur(s)
Yeo, Boon Thye Thomas
Kong, Ru
Asplund, Christopher Lee
Xue, Aihuiping
Tor, Phern Chern
Tan, Xiaowei
Siddiqi, Shan H.
Fox, Michael D.
Cocchi, Luca
Burgher, Bjorn
Abrégé
Disclosed is a method for determining a treatment to be applied to a brain of a patient, such as determining a transcranial magnetic stimulation (TMS) treatment location(s) and treatment strength to be applied to a brain of a patient suffering from depression. A search of the brain, based on coarse-scale parcellations, treatment metric and one or more anatomical metrics, is conducted to select the treatment location(s). In one embodiment, this involves progressively varying a value of a parameter associated with a gyrus threshold and for each value, identifying candidate treatment locations based on a functional connectivity of a subgenual anterior cingulate cortex during resting-state functional magnetic resonance imaging (fMRI) recorded over a plurality of multimodal brain imaging sessions, and selecting as the respective treatment location the candidate location that is closest to all other candidate treatment locations.
G16H 20/00 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients
A61N 2/04 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants utilisant des champs variables, p. ex. des champs basse fréquence ou des champs pulsés
31.
A HIGH-ENTROPY GEL COMPOSITION AND METHOD OF PRODUCING THEREOF
The present invention describes a high-entropy gel (HEG) composition derived from organic raw materials and method of producing thereof. Particularly, the composition comprises a high-entropy gel composition derived from organic materials, the composition comprising at least a semi-crystalline polymeric backbone and at least four different crystalline components in a non-equimolar ratio, wherein the at least four crystalline components interact with one another via reversible physical bonds of hydrogen bonds, ionic interactions and ion-dipole interactions hence forming a homogeneous, free-standing gel. The high-entropy gel composition provides enhanced ionic conductivity and high dielectric permittivity, thus enabling it to be used to fabricate self-healing sensors, for use in green electronics, soft robotics, environmental and healthcare industries. HEG is self- healing, reusable and biodegradable and can be used to make a tough packaging material, for example, to keep fruits and vegetables fresh.
C08L 101/14 - Compositions contenant des composés macromoléculaires non spécifiés caractérisées par des propriétés physiques, p. ex. anisotropie, viscosité ou conductivité électrique les composés macromoléculaires étant solubles dans l'eau ou gonflables dans l'eau, p. ex. gels aqueux
There is provided a method of forming a fiber, the method comprising preparing a dope comprising a metal ion coordination polymer; and forming a precursor fiber from the dope in air, wherein the precursor fiber undergoes a phase transition from a liquid or semi-liquid state to the fiber in a solid state in air. There is also provided a fiber comprising a metal ion coordination polymer, said metal ion coordination polymer comprising, a plurality of metal ions acting as nodes; and a plurality of organic ligands acting as linkers, wherein the metal ions are linked to the organic ligands via coordination bonds to form a network structure of the metal ion coordination polymer. There is further provided an article comprising one or more strands of fibers formed by the method as disclosed herein, or one or more strands of fibers as disclosed herein.
D01F 1/09 - Addition de substances à la solution de filage ou à la masse fondue pour fabriquer des filaments électroconducteurs ou antistatiques
C08J 3/11 - Production de solutions, dispersions, latex ou gel par d'autres procédés que ceux utilisant les techniques de polymérisation en solution, en émulsion ou en suspension dans des liquides organiques à partir de polymères solides
C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
D01F 6/18 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiquesLeur fabrication à partir d'homopolymères obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone à partir de polymères de nitriles non saturés, p. ex. à partir de polyacrylonitrile, de cyanure de polyvinylidène
The present disclosure concerns an imaging sensor comprising an optical encoder comprising a layer of at least four transducers stochastically arrayed on a substrate, the four transducers configured to each independently absorb a different wavelength of electromagnetic wave; and a charge-coupled device (CCD) in electromagnetic communication with the optical encoder for receiving visible light from the at least four transducers and outputting a combined image.
G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
H10F 39/15 - Capteurs d’images à couplage de charge [CCD]
H04N 23/10 - Caméras ou modules de caméras comprenant des capteurs d'images électroniquesLeur commande pour générer des signaux d'image à partir de différentes longueurs d'onde
An imaging system is provided. The imaging system includes a beamsplitter, a first optical arm, a second optical arm and or more detectors arranged to receive an image from the beamsplitter. The first optical arm includes a first objective lens, a first phase plate and a first mirror. The first mirror is arranged to direct emission from the first objective lens through the first phase plate towards the beamsplitter. The second optical arm includes a second objective lens, a second phase plate and a second mirror. The second mirror is arranged to direct emission from the second objective lens through the second phase plate towards the beamsplitter. The first and second objective lenses and are in an opposing relationship.
5 This invention provides an apparatus for monitoring chemical reactions, the apparatus comprising at least one layer adapted to excite surface phonon polariton, at least one layer adapted to excite localized surface plasmon polariton, and a substrate, wherein the layers are stacked alternately on the substrate, and are further adapted to exhibit a plasmon-10 phonon coupling mode upon exposure to radiation for vibrational fingerprinting of molecules from the monitored chemical reactions based on their refractive index. The invention further provides a system and method involving the apparatus. 1 for publication. 15
G01N 21/3577 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de liquides, p. ex. l'eau polluée
G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
G01N 21/41 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique
B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
This disclosure concerns methods for predicting treatment outcome to a cancer therapy (in particular combination therapy with CHOP or R-CHOP) by detecting the level of macrophage immunometabolism regulator (MACIR) expression in a subject, wherein an increased MACIR expression indicates likely non-responsiveness to the cancer therapy. Also provided are methods of treating refractory cancer using MACIR inhibitors.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
The present invention relates to a polymer electrolyte comprising a co-polymer and alkali metal ions, the co-polymer comprising a first, a second and optionally a third constitutional unit, wherein, the first constitutional unit is formed from a first monomer selected from the group consisting of a 5 to 8 membered cyclic carbonate and a 5 to 8 membered cyclic ether, wherein said cyclic carbonate or cyclic ether comprises an unsaturated carbon-carbon bond or is substituted by a methylidene, vinyl or allyl group, and is unsubstituted or substituted by one or two C1-6alkyl or phenyl groups; the second constitutional unit is formed from a second monomer selected from the group consisting of a C1-6alkyl acrylate and a C1-6alkyl methacrylate, said C1-6alkyl of the C1-6alkyl acrylate or C1-6alkyl methacrylate substituted by one or more halogen atoms; and the third constitutional unit is formed from a third monomer selected from the group consisting of a poly(ethylene glycol) acrylate and poly(ethylene glycol) methacrylate Also disclosed herein is a method of preparing the polymer electrolyte of the present invention and a battery comprising the polymer electrolyte of the present invention.
C08F 224/00 - Copolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un hétérocycle contenant de l'oxygène
C08F 234/02 - Copolymères de composés cycliques ne contenant pas de radicaux aliphatiques non saturés dans une chaîne latérale et contenant une ou plusieurs liaisons doubles carbone-carbone dans un hétérocycle dans un cycle contenant de l'oxygène
H01M 10/0565 - Matériaux polymères, p. ex. du type gel ou du type solide
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
An optical Ising machine and a method of applying an optical Ising machine for solving a combinatorial optimization problem. The method comprises the steps of splitting a reference optical signal into M beams and at least one reference beam; encoding an input vector of size M by respective amplitudes and/or phases of the M beams; performing multiplication of the input vector of size M and a matrix of size M×M to generate an output vector of size M encoded on the M beams; extracting respective amplitudes and phases of the M beams after the optical matrix processing unit using the reference beam for determining components of the output vector of size M; and applying new phase biases in the encoding of respective ones of the M beams based on the components of the output vector of size M for a next iteration of the optical Ising machine.
G06E 1/04 - Dispositions pour traiter exclusivement des données numériques agissant sur l'ordre ou le contenu des données maniées pour effectuer des calculs en utilisant exclusivement une représentation numérique codée, p. ex. représentation binaire, ternaire, décimale
G06N 7/01 - Modèles graphiques probabilistes, p. ex. réseaux probabilistes
39.
METHODS OF TREATING CANCER USING ENGINEERED LACTOBACILLUS BACTERIA
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
CLEGG, Richard (Royaume‑Uni)
Inventeur(s)
Chang, Matthew Wook
Shen, Haosheng
Hwang, In Young
Lee, Yung Seng
Abrégé
The present invention relates to engineered Lactobacillus. In particular, engineered Lactobacillus carrying a prodrug presented on their surface. A cleavable linker within the prodrug allows the targeted release of the drug. Methods of treating cancer, compositions and kits are also described herein.
C07K 14/335 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Lactobacillus (G)
C07K 14/36 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant d'ActinomycesPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Streptomyces (G)
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
Inventeur(s)
Chiong, Edmund
Wu, Qing Hui
Wang, Ziting
Law, Yu Xi Terence
Phee, Soo Jay Louis
Miyasaka, Muneaki
Liu, Jiajun
Lai, Wenjie
Abrégé
Disclosed herein is a transurethral resection device. The device comprising: a housing defining a channel, the channel extending along an axial direction; a grasper assembly disposed in the channel, the grasper assembly being movable relative to the channel along the axial direction, the grasper assembly including: a grasper; a first elongated body; and a first continuum joint coupled between the first elongated body and the grasper; and a cutter assembly disposed in the channel, the cutter assembly being movable relative to the channel along the axial direction, the cutter assembly including: a cutter; a second elongated body; and a second continuum joint coupled between the second elongated body and the cutter, the second continuum joint being actuatable to displace the cutter in relative to the second elongated body, wherein the first continuum joint and the second continuum joint are actuatable independently of one another.
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
This invention describes a data-driven bunker planner system (11) for optimising refuel costs for a marine vessel (1). The bunker planner system (11) operates on a computing system (10) located on the vessel (1) and includes a data acquisition module (111), a fuel-price forecasting module (112) and a data optimisation module (113). The fuel-price forecasting module (112) forecasts the future fuel prices and/or fuel indexes in the long-term or the short-term. The data optimisation module (113) determines an optimal time to fulfil a refuel term contract or combinations of contracts based on the forecasted fuel prices and/or fuel indexes. The forecasted fuel prices and/or fuel indexes, the optimised fuel term contracts and a bunkering plan are outputted through a notification generation module (114) and a human-machine interface system (18). The bunker planner system outputs have been verified using real-life data trained on various customized machine learning and optimization models.
G06Q 10/04 - Prévision ou optimisation spécialement adaptées à des fins administratives ou de gestion, p. ex. programmation linéaire ou "problème d’optimisation des stocks"
G06Q 30/0283 - Estimation ou détermination de prix
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
CLEGG, Richard (Royaume‑Uni)
Inventeur(s)
Chang, Matthew Wook
Shen, Haosheng
Hwang, In Young
Lee, Yung Seng
Abrégé
The present invention relates to engineered Lactobacillus. In particular, engineered Lactobacillus for the delivery of drugs to the central nervous system (CNS) by traversing the olfactory epithelium. Methods of treating a disease or disorder of the CNS, pharmaceutical compositions and kits are also described herein.
C07K 14/335 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Lactobacillus (G)
Disclosed herein are a metal-air fuel cell metal source material, a composite material comprising a metal selected from an alkali metal, an alkaline earth metal, aluminium, zinc, or iron, a conductive carbon material, and a binder, a redox-mediated metal-air fuel cell cartridge comprising a cartridge housing, and a composite material comprising a metal selected from an alkali metal, an alkaline earth metal, aluminium, zinc, or iron, a conductive carbon material, and a binder, and a redox-mediated metal-air fuel cell system comprising a redox flow cell and a first tank suitable to house an anolyte and a redox-mediated metal-air fuel cell cartridge. Also disclosed herein is a method of feeding a metal in a redox-mediated metal-air fuel cell system.
A classifying sensing system, a classifying method performed using a sensing system, a tactile sensor, and a method of fabricating a tactile sensor. The classifying sensing system comprises a first spiking neural network, SNN, encoder configured for encoding an event-based output of a vision sensor into individual vision modality spiking representations with a first output size; a second SNN encoder configured for encoding an event-based output of a tactile sensor into individual tactile modality spiking representations with a second output size; a combination layer configured for merging the vision modality spiking representations and the tactile modality spiking representations; and a task SNN configured to receive the merged vision modality spiking representations and tactile modality spiking representations and output vision-tactile modality spiking representations with a third output size for classification.
Provided herein is a redox flow battery, comprising:
a catholyte compartment, comprising a catholyte, and a cathode;
an anolyte compartment, comprising an anolyte, and an anode comprising a first metal; and
an ion selective membrane disposed between the cathode compartment and anode compartment,
wherein:
the first metal is selected from the group consisting of an alkali metal, an alkaline earth metal, a Group III metal, and a transition metal;
the anolyte comprises an anodic redox mediator; and
the anodic redox mediator has a redox potential versus a standard hydrogen electrode that is more positive than a redox potential of the first metal versus a standard hydrogen electrode.
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
Inventeur(s)
Panengad, Pradeep Paul
Unniyampurath, Unnikrishnan
Wang, Linfa
Dharmaraj, Rajesh Babu
Nambiar, Ajay Purushothaman
Anantharajan, Senthil Kumar
Naduparambil, Manoj Krishnan
Abrégé
A device for debriding tissue is described. In an embodiment, the device comprises an electrolysis unit 300 having two electrodes 306, 310. The electrolysis unit 300 is configured to receive an electrolyte for electrically connecting the two electrodes 306, 310. The two electrodes 306, 310 are adapted to connect to a power supply 314 to receive an electric current for electrolysis of the electrolyte, where in use, one of the two electrodes 306, 310 is adapted to provide an acidic region or an alkaline region to the tissue during electrolysis of the electrolyte for debriding the tissue. A method for debriding tissue using the aforementioned device is also described.
Provided in the embodiments of the present application are a blood pressure sensor, a wearable device, and a blood pressure measurement method. The blood pressure sensor comprises a magnetic source and a magnetic sensor. A buffer is arranged between the magnetic sensor and a skin and used for weakening vibration of the magnetic sensor when an artery vibrates, or a buffer is arranged between the magnetic source and the skin and used for weakening vibration of the magnetic source when an artery vibrates. The magnetic sensor is used for collecting magnetic field change data. The magnetic field change data is used for generating blood pressure data, and the magnetic field change is generated based on relative displacement between the magnetic source and the magnetic sensor caused by the artery vibration. By adopting the means, the generation of accurate blood pressure data is facilitated. Moreover, the scheme requires no other additional user operations, thereby improving the convenience and comfort of the user.
Methods of depositing silicon-containing layers in the formation of semiconductor devices are described. The methods include a thermal chemical vapor deposition (CVD) process or a thermal atomic layer deposition (ALD) process without the use of plasma. Some methods include exposing a semiconductor substrate to a silicon-containing precursor, an oxygen-containing reactant, and an initiator compound to deposit a silicon oxide layer. Some methods include exposing a semiconductor substrate to a silicon-containing precursor, a nitrogen-containing reactant, and an initiator compound to deposit a silicon nitride layer. Some methods include exposing a semiconductor substrate to a silicon-containing precursor, an oxygen-containing reactant, a nitrogen-containing reactant, and an initiator compound to deposit a silicon oxynitride layer.
Disclosed herein is an acoustic barrier. The acoustic barrier comprises a frame defining a plurality of receiving positions and an acoustic axis; a plurality of first acoustic metablocks detachably coupled to respective first ones of the plurality of receiving positions; and a plurality of second acoustic metablocks detachably coupled to respective second ones of the plurality of receiving positions, wherein each of the plurality of first acoustic metablocks defines a first acoustic transmission loss spectrum, and each of the plurality of second acoustic metablocks defines a second acoustic transmission loss spectrum, wherein the first acoustic transmission loss spectrum is distinct from the second acoustic transmission loss spectrum.
Disclosed herein are probes for detecting the presence of one or more target proteins, the probe comprising a structure I1 and a structure I2. Also disclosed herein are methods of using the same.
This document describes a resistive random-access memory (RRAM) device and a method for manufacturing the same. This application also relates to a one-transistor and one-resistor array circuit that includes a plurality of RRAM device and transistor pairs, and a method for manufacturing the array circuit.
A graphene oxide-thermoresponsive polymer composite film There is provided a two-dimensional (2D) graphene oxide-thermoresponsive polymer composite film comprising: at least two graphene oxide (GO) layers: and a thermoresponsive polymer layer between each GO layer, wherein the thermoresponsive polymer layer switches between being aligned and being disoriented between the at least two GO layers when temperature of the composite film changes from being below lower critical solution temperature (LCST) of the thermoresponsive polymer comprised in the composite film to being above the LCST of the thermoresponsive polymer. There is also provided a method of forming the composite film.
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapour)
NATIONAL UNIVERSITY OF SINGAPORE (Singapour)
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
TAN TOCK SENG HOSPITAL PTE LTD (Singapour)
Inventeur(s)
Zhong, Liang
Baskaran, Lohendran
Leng, Shuang
Tan, Eddy
Lee, Hwee Kuan
Cheng, Nicholas
Singh, Malay
Roperos Go, Mary Chris
Huang, Weimin
Chan, Yan Yee Mark
Ngiam, Kee Yuan
Teo, Li San Lynette
Yew, Min Sen
Abrégé
Disclosed herein is a system for analysing arterial calcium. The system identifies calcium lesions, within an organ boundary, from Non-Contrast Computed Tomography (NCCT) images. A feature learning model is then used to generate a set of images based on an origin of each calcium lesion in the NCCT images and orthogonal axes through that origin and to learn, for each image in the set, calcium image features, inferring detection or otherwise of a calcium lesion in the respective image. A feature vector comprising the calcium image features is then formed for each image, and the feature vectors are concatenated to facilitate generation of a prediction for each calcium lesion, of an artery in which the respective calcium lesion is located. Finally, a scorer predicts a calcium score based on the predictions generated from each calcium lesion.
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapour)
NATIONAL UNIVERSITY OF SINGAPORE (Singapour)
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
TAN TOCK SENG HOSPITAL PTE LTD (Singapour)
Inventeur(s)
Zhong, Liang
Baskaran, Lohendran
Leng, Shuang
Huang, Su
Huang, Weimin
Lu, Zhongkang
Wang, Xiaohong
Lee, Beng Hai
Lee, Hwee Kuan
Chan, Yan Yee Mark
Ngiam, Kee Yuan
Teo, Li San Lynette
Yew, Min Sen
Abrégé
Disclosed herein are systems and methods for extracting, from an image, a centreline for each of one or more vessels of a vasculature, the system comprising memory, and at least one processor, the memory storing instructions that, when executed by the at least one processor, cause the system to receive, at a receiver system, a first mask of a portion of the vasculature, identify seed points in the image, using a shape analysis model, based on a shape of the vasculature in the first mask, generate, using a centreline tracing model, the centreline for each of the one or more vessels by tracing a traced centreline from each seed point, selecting a candidate centreline from the traced centrelines, based on an anatomical feature of the portion of the vasculature, and filtering the candidate centrelines using one or more geometric shape filters to generate the centreline for each vessel. Finally, a centreline for each vessel is provided as an output.
Methods of depositing silicon-containing layers in the formation of semiconductor devices are described. The methods include a thermal chemical vapor deposition (CVD) process or a thermal atomic layer deposition (ALD) process without the use of plasma. Some methods include exposing a semiconductor substrate to a silicon-containing precursor, an oxygen-containing reactant, and an initiator compound to deposit a silicon oxide layer. Some methods include exposing a semiconductor substrate to a silicon-containing precursor, a nitrogen-containing reactant, and an initiator compound to deposit a silicon nitride layer. Some methods include exposing a semiconductor substrate to a silicon-containing precursor, an oxygen-containing reactant, a nitrogen-containing reactant, and an initiator compound to deposit a silicon oxynitride layer.
C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction
The present invention describes heat sinks (100) in which fins (120) are hybrid 3D printed using laser powder-bed fusing (LPBF) or selective laser melting (SLM) (200) of a fin powder (122) deposited directly over a substrate (140). The fin powder (122) forms a powder-bed, which height is increased, layer by layer, and the fins (120) are being built up, layer by layer, by laser melting and fusing the fin powder (122). The fin powder (122) may be copper, copper alloy, aluminium or aluminium alloy, whilst the associated substrate (140) is copper-based or aluminium-based. The substrate (140) is prepared by conventional machining, hence, the process (200) is called hybrid LPBF or SLM. The heat sinks (100) obtained have excellent heat dissipation and temperature stability performances.
B33Y 80/00 - Produits obtenus par fabrication additive
F28F 3/04 - Éléments ou leurs ensembles avec moyens pour augmenter la surface de transfert de chaleur, p. ex. avec des ailettes, avec des évidements, avec des ondulations les moyens faisant partie intégrante de l'élément
57.
METHODS OF DEPOSITING SILICON-CONTAINING DIELECTRIC LAYERS FOR SEMICONDUCTOR DEVICES
Methods of depositing silicon-containing layers in the formation of semiconductor devices are described. The methods include a thermal chemical vapor deposition (CVD) process or a thermal atomic layer deposition (ALD) process without the use of plasma. Some methods include exposing a semiconductor substrate to a silicon-containing precursor, an oxygen-containing reactant, and an initiator compound to deposit a silicon oxide layer. Some methods include exposing a semiconductor substrate to a silicon-containing precursor, a nitrogen-containing reactant, and an initiator compound to deposit a silicon nitride layer. Some methods include exposing a semiconductor substrate to a silicon-containing precursor, an oxygen-containing reactant, a nitrogen-containing reactant, and an initiator compound to deposit a silicon oxynitride layer.
C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapour)
Inventeur(s)
Schwarz, Herbert Josef
Sun, Rui
Wang, Cheng-I
Huang, Ching-Wen
Ngoh, Eve Zi Xian
Abrégé
Disclosed is an antibody or an antigen binding fragment thereof comprising a heavy chain 5 variable region comprising CDR-H1 of SEQ ID NO:1, CDR-H2 of SEQ ID NO:2, CDR- H3 of SEQ ID NO:3, and a light chain variable region comprising CDR-L1 of SEQ ID NO:4, CDR-L2 of SEQ ID NO:5, CDR-L3 of SEQ ID NO:6, or an amino acid sequence having at least 80% sequence identity with these sequences, wherein the antibody or antigen binding fragment binds to CD137 antagonistically. Also disclosed is a method of 0 treating a cancer or a non-malignant disease in a subject in need thereof, comprising administering to the subject the antibody or antigen binding fragment thereof as disclosed herein.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (Singapour)
NATIONAL UNIVERSITY OF SINGAPORE (Singapour)
Inventeur(s)
Keng, Choong Tat
Chu, Jang Hann
Chew, Wei Leong
Lee, Ching Hua
Abrégé
Disclosed herein are molecular systems comprising an RNA-guided RNA-targeting effector protein, and one or more guide RNA molecule (gRNA). Also disclosed herein are guide RNA molecules for use in the systems disclosed herein, as well as the use of the described systems in the treatment or prevention of disease.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
Southern University of Science and Technology (Chine)
Inventeur(s)
Lim, Zhi Shiuh
Li, Changjian
Abrégé
A magnetic device includes a magnetic layer having a ferromagnetic phase to support magnetic skyrmions and an antiferromagnetic phase to annihilate magnetic skyrmions. The magnetic layer transmits between the ferromagnetic and antiferromagnetic phases. A ferroelectric layer is adapted to magnetoelectrically couple with the magnetic layer causing the magnetic layer to transit between the ferromagnetic and antiferromagnetic phases in response to a polarization state of the ferroelectric layer. The polarization state includes a first polarization state corresponding to the ferromagnetic state and a second polarization state corresponding to the antiferromagnetic state. First and second electrodes can be configured to sandwich the magnetic and ferroelectric layers. The first and second electrodes can be adapted to receive applied voltage for switching the polarization state of the ferroelectric layer to control a phase transition of the magnetic layer between the ferromagnetic and antiferromagnetic phases to create or annihilate magnetic skyrmions in the magnetic layer.
G11C 11/16 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments magnétiques utilisant des éléments dans lesquels l'effet d'emmagasinage est basé sur l'effet de spin
A device for weight adjustment in an optical neural network is provided. The device includes a first waveguide configured to receive and transmit an input optical signal. The input optical signal is defined by an amplitude and a first wavelength. The device further includes an optical resonator in optical communication with the first waveguide. The optical resonator has a first refractive index and is defined by a first resonance frequency. The amplitude of the input optical signal is modulated by the optical resonator based on the first resonance frequency to obtain a first weighted input optical signal. The device further includes a second waveguide optically coupled with the optical resonator. The second waveguide is configured to transmit a backpropagation optical signal that is defined by a second wavelength. The backpropagation optical signal is partially coupled into the optical resonator to adjust the first resonance frequency to a second resonance frequency. An amplitude of a subsequent input optical signal is modulated by the optical resonator based on the second resonance frequency to obtain a second weighted input optical signal.
G06N 3/067 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens optiques
G02F 1/21 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur par interférence
G02F 1/225 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur par interférence dans une structure de guide d'ondes optique
G06N 3/084 - Rétropropagation, p. ex. suivant l’algorithme du gradient
Disclosed is a construct for preventing antibody-dependent enhancement of dengue virus infection, comprising: (a) a ribonucleic acid encoding a non-structural protein of a dengue virus wherein each of the uridine residues of the ribonucleic acid encoding a non-structural protein of a dengue virus is replaced with pseudouridine; (b) a 7-methylguanylate cap; (c) a 5' untranscribed region preferably comprising a kozak consensus ribonucleic acid sequence; (d) a 3' untranscribed region; and (e) a poly A tail and a method for using the construct to prevent antibody-dependent enhancement of dengue virus infection
Disclosed is a multi-layer contact structure comprising a semiconductor substrate, a terminal electrode, and a contact layer structure. The contact layer structure comprises a metal-containing carrier selective (MCS) layer, the contact layer structure being in intimate contact with the semiconductor substrate and the terminal electrode.
Disclosed is a synthetic β-hairpin antimicrobial peptide (AMP) comprising (a) a recognition module comprising a hairpin turn for interacting with a bacterial membrane component to initiate amyloid nucleation; and (b) a structural module comprising a first side strand and a second side strand for β-sheet formation and molecular stacking during fibrillation; wherein the synthetic β-hairpin AMP comprises the sequence of SEQ ID NO: 1 or SEQ ID NO: 2; and wherein the synthetic β-hairpin AMP self-assembles into nanonets in the presence of the bacterial membrane component or a bacterium. Also disclosed is a pharmaceutical or adjuvant composition comprising the AMP. Also disclosed is a method for treating a condition associated with a bacterial infection, or an immune-related disease, or for delaying the development of antibiotic resistance in a subject in need thereof using the AMP or composition.
Methods and systems for decomposing a quantum circuit are described A method of decomposing a quantum circuit comprises: dividing the quantum circuit into a first sub- circuit and second sub-circuit; determining a pre-processing unitary operator and a post-processing unitary operator which approximate local evolutions on the first sub- circuit and second sub-circuit; determining gate decompositions of the pre-processing unitary operator and the post-processing unitary operator; and using the gate decompositions of the pre-processing unitary operator and the post-processing unitary operator to determine a gate decomposition of the quantum circuit.
This disclosure concerns near infrared organic fluorescence compounds, synthesis methods and applications thereof. The near infrared organic fluorescence compounds may be used for treating a disease or disorder associated with bacteria.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
A61K 31/4425 - Dérivés de pyridinium, p. ex. pralidoxime, pyridostigmine
This disclosure concerns organic fluorescent compounds, synthesis methods and applications thereof. The compounds may be used for treating a microbial disease or disorder.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
A61K 31/4425 - Dérivés de pyridinium, p. ex. pralidoxime, pyridostigmine
A homojunction device and a method of fabricating a homojunction device. The homojunction device comprises a programming electrode, a dielectric stack on the programming electrode, the dielectric stack comprising a ferroelectric material and a dielectric layer disposed between the ferroelectric material and the programming electrode; an ambipolar material on the dielectric stack on an opposite side thereof compared to the programming electrode; and a first electrode and a second electrode each electrically connected to the ambipolar material; wherein the ambipolar material extends beyond the ferroelectric material to be in contact with the dielectric layer in a first area of the ambipolar material; wherein the first electrode is electrically connected to the first area of the ambipolar material and the second electrode is electrically connected to a second area of the ambipolar material overlapping the ferroelectric material; and wherein, in the second area, the ambipolar material is programmable to be either p-type or n-type through application of a voltage pulse to the programming electrode for forming a homojunction comprising the first area and the second area of the ambipolar material. 3A
H10F 30/221 - Dispositifs individuels à semi-conducteurs sensibles au rayonnement dans lesquels le rayonnement commande le flux de courant à travers les dispositifs, p. ex. photodétecteurs les dispositifs ayant des barrières de potentiel, p. ex. phototransistors les dispositifs étant sensibles au rayonnement infrarouge, visible ou ultraviolet les dispositifs ayant une seule barrière de potentiel, p. ex. photodiodes la barrière de potentiel étant une homojunction PN
H10F 71/00 - Fabrication ou traitement des dispositifs couverts par la présente sous-classe
This disclosure concerns photosensitiser compounds, synthesis methods and applications thereof. The compounds may be used for treating a disease or disorder associated with bacteria.
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61K 31/538 - 1,4-Oxazines, p. ex. morpholine condensées en ortho ou en péri avec des systèmes carbocycliques
A61K 31/5415 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame condensés en ortho ou en péri avec des systèmes carbocycliques, p. ex. phénothiazine, chlorpromazine, piroxicam
A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
xyy, wherein A is a transition metal and B is a chalcogenide, and wherein 0 < x < 2 and 0 < y < 2. Also provided are a proton exchange membrane (PEM) water electrolyser, a method of water electrolysis, use of a transition metal oxychalcogenide as a catalyst in an oxygen evolution reaction under acidic conditions, and a method of manufacturing an anode for an electrolyser.
C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
C25B 11/052 - Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques
C25B 11/075 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’un seul élément catalytique ou composé catalytique
71.
DIGITAL ASSET RISK INFORMATION PROCESSING METHOD AND SYSTEM
NATIONAL UNIVERSITY OF SINGAPORE CHONGQING RESEARCH INSTITUTE (Chine)
Inventeur(s)
Pang, Yan
Yan, Ran
Abrégé
The present invention provides a digital asset risk information processing method and system. The method comprises: acquiring web2 multimodal source data (including but not limited to various modalities such as text, images, speech, and videos) and web3 source data; converting web2 non-text source data into web2 text processing data; filtering web2 text source data and the web2 text processing data to obtain web2-related risk information involving a digital asset; acquiring web2 statistical information from the web2 text source data and the web2 text processing data; extracting from the web3 source data web3-related risk information involving the digital asset; inputting the web2 statistical information and the web3-related risk information into a first machine learning model to obtain a risk score involving the digital asset and a corresponding risk information feature; and inputting the filtered web2 text data and the web3-related risk information into a second machine learning model to obtain a risk analysis and prevention and control strategy involving the digital asset.
Described herein are receptor configurations that allow ligation of multiple targets expressed in cancer cells via two main mechanisms: direct binding via an antibody-derived single chain variable fragment (scFv), and indirect binding through the high-affinity engagement of the Fc component of an antibody. When expressed in human T lymphocytes, these receptors (CARFcR) can trigger powerful CAR-T cell activity as well as antibody- dependent cell cytotoxicity (ADCC), either simultaneously or sequentially. CARFcR T cells are not affected by soluble antibodies, but they can be redirected and activated by antibodies bound to target cells. Therefore, such T cells can be used to redirect adoptive T cell therapy towards another tumor-associated antigen "on the fly" using clinically available antibodies. They also provide a practical way to target multiple antigens simultaneously with a single receptor, a feature that should be useful in cell therapies directed against phenotypically heterogeneous tumors.
A61K 40/11 - Lymphocytes T, p. ex. lymphocytes infiltrant les tumeurs [TIL] ou lymphocytes T régulateurs [Treg]Cellules tueuses activées par les lymphokines [LAK]
The present disclosure relates to a catalyst composition comprising a first metal complex and optionally a second metal complex dispersed throughout a matrix of an inorganic material. The present disclosure also relates to a method for preparing the catalyst composition, a catalyst comprising the catalyst composition, use of the catalyst composition as a catalyst or the catalyst for converting natural gas to syngas and a method for converting natural gas to syngas using the catalyst composition as a catalyst or the catalyst.
B01J 31/18 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination contenant de l'azote, du phosphore, de l'arsenic ou de l'antimoine
C01B 3/40 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés organiques gazeux ou liquides avec des agents gazéifiants, p. ex. de l'eau, du gaz carbonique, de l'air par réaction d'hydrocarbures avec des agents gazéifiants avec des catalyseurs caractérisée par le catalyseur
74.
POLYMER COMPOSITES FOR HARVESTING MOISTURE AND METHODS OF FABRICATION THEREOF
The present disclosure concerns polymer composites for harvesting moisture and their uses thereof. The polymer composite comprises a hydrophilic polymer network and a hygroscopic salt intercalated within the polymer network. The weight ratio of the polymer network to the salt is about 0.1:1 to about 15:1. The present disclosure also concerns methods of fabricating the polymer composites.
B01D 53/02 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p. ex. chromatographie préparatoire en phase gazeuse
B01D 53/28 - Emploi de substances spécifiées comme agents desséchants
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
The present invention relates to a WOx-based hole-selective contact layer designed for use in photovoltaic cells. This WOx-based hole-selective contact layer comprises at least one WOx layer with a thickness ranging from 1 to 200 nm, and may be configured as multiple layers, featuring an inner layer in direct contact with a silicon wafer substrate and an outer layer in contact with an electrode. The present invention is designed to minimize interface resistance between the layers and their respective contacts, thereby enhancing the efficiency of photovoltaic cells. Furthermore, the present invention provides a method for manufacturing the WOx-based contact layer using a plasma- enhanced chemical vapor deposition (PECVD) process with optimized gas ratios, and the method can be applied to various types of silicon wafer substrates in solar cells, including tandem solar cells.
H10F 10/164 - Cellules photovoltaïques ayant uniquement des barrières de potentiel du type à hétérojonction PN comprenant des hétérojonctions avec des matériaux du groupe IV, p. ex. cellules photovoltaïques ITO/Si ou GaAs/SiGe
The invention relates to a SiCx-based carrier-selective contact layer, which comprises at least one i-aSi layer and at least one conductive film layer stacked sequentially, with a front contact layer arranged between them. The front contact layer comprises at least one SiCx layer, which can be P-type, N-type, or intrinsic, with a total thickness of 2-80 nm. The invention also describes a method for manufacturing this contact layer using a PECVD method, with specific gas ratios for deposition. Additionally, the invention discloses a photovoltaic cell comprising a silicon wafer substrate with at least one SiCx- based carrier-selective contact layer on either the front or back side, or both.
H10F 10/17 - Cellules photovoltaïques ayant uniquement des barrières de potentiel du type jonction PIN
H10F 10/19 - Cellules photovoltaïques ayant plusieurs barrières de potentiel de type différent, p. ex. cellules dites "tandem" comprenant à la fois des jonctions PN et des jonctions PIN
H10F 71/10 - Fabrication ou traitement des dispositifs couverts par la présente sous-classe les dispositifs comprenant des matériaux semi-conducteurs amorphes
H10F 77/1226 - Matériaux actifs comportant uniquement des matériaux du groupe IV comportant plusieurs éléments du groupe IV, p. ex. SiC
Various embodiments may relate to a transistor including a channel, a source and a drain in contact with opposite ends of the channel. The transistor may also include a first gate, and a first gate dielectric layer including a portion between the first gate and the channel. The transistor may also include a second gate, and a second gate dielectric layer including a portion between the second gate and the channel. The channel may include a first oxide-semiconductor layer including a first oxide-semiconductor material, a second oxide-semiconductor layer including a second oxide-semiconductor material, and a middle oxide-semiconductor layer between the first oxide-semiconductor layer and the second oxide-semiconductor layer, the middle oxide-semiconductor layer including a third oxide-semiconductor material. The third oxide-semiconductor material may have a bond dissociation energy lower than a bond dissociation energy of the first oxide-semiconductor material and a bond dissociation energy of the second oxide-semiconductor material.
H01L 29/66 - Types de dispositifs semi-conducteurs
H01L 21/28 - Fabrication des électrodes sur les corps semi-conducteurs par emploi de procédés ou d'appareils non couverts par les groupes
H01L 29/51 - Matériaux isolants associés à ces électrodes
H01L 29/78 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée
H10B 51/20 - Dispositifs de RAM ferro-électrique [FeRAM] comprenant des transistors ferro-électriques de mémoire caractérisés par les agencements tridimensionnels, p. ex. avec des cellules à des niveaux différents de hauteur
78.
SOY WHEY-BASED PRODUCT ENRICHED WITH VITAMIN B12 AND METHOD OF PRODUCING THE SAME
The present invention relates to a sodium alginate-based composite aerogel and a method of preparing the sodium alginate-based composite aerogel The composite comprises a cross-linked sodium alginate and carbon nanotubes (SA/CNTs) composite aerogel, impregnated with a magnesium complex or a metal-ethanolamine complex. The composite of the present invention provides a sustainable and energy-efficient material for desiccants and freshwater production.
C08J 3/02 - Production de solutions, dispersions, latex ou gel par d'autres procédés que ceux utilisant les techniques de polymérisation en solution, en émulsion ou en suspension
The disclosure concerns conjugated oligoelectrolytes as represented by Formula (I) and their methods of use thereof. The conjugated oligoelectrolytes are suitable for use to stain mitochondria.
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
C07D 233/58 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes d'azote du cycle
The present disclosure concerns a method of converting carbon dioxide to a multi-carbon compound, comprising contacting a working electrode with an electrolyte; and applying a voltage or current to the working electrode; wherein the working electrode comprises a pre-catalyst; wherein the pre-catalyst comprises at least partially etched Cu based Prussian Blue Analogue and CuO as an etched product; and wherein under the applied voltage or current, the pre-catalyst is convertible into a catalyst in order to convert carbon dioxide to a multi-carbon compound. The present disclosure also concerns an electrode having a surface thereof; wherein the surface comprises a pre- catalyst; wherein the pre-catalyst comprises at least partially etched Cu based Prussian Blue Analogue and CuO as an etched product; and wherein under a voltage or current, the pre-catalyst is convertible into a catalyst in order to convert carbon dioxide to a multi-carbon compound.
C25B 11/091 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques
Disclosed is a method for fabricating a solar module. The method involves providing a single processing tool (which may be a system) a plurality of tandem solar cells, electrically conductive adhesive (ECA) and a protective assembly. The tool produces an assembled lay-up of protected, interconnected, partially cured cells by forming a string by aligning the cells and applying ECA to both sides of the cells, placing the string on the protective assembly, and pre-curing the ECA at low temperature (80° C.-150° C.). Thereafter, external connections are formed, a protective assembly is applied to a second side of each cell, opposite the first side, and the lay-up is laminated to produce a solar module
H10F 71/00 - Fabrication ou traitement des dispositifs couverts par la présente sous-classe
H01L 21/677 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitementAppareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants pour le transport, p. ex. entre différents postes de travail
H01L 21/68 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitementAppareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants pour le positionnement, l'orientation ou l'alignement
H10F 10/172 - Cellules photovoltaïques ayant uniquement des barrières de potentiel du type jonction PIN comprenant plusieurs jonctions PIN, p. ex. cellules dites "tandem"
H10F 19/90 - Structures pour la connexion des cellules photovoltaïques, p. ex. interconnexions ou espaceurs isolants
The present invention provides a method of recovering one or more metals from at least two active materials obtained from an alkali metal ion battery, the method comprising (a) providing a first active material and a second active material, each of the active materials comprising alkali metal ions, the first active material having a reduction potential greater than the reduction potential of the second active material; (b) adding the first and second active materials to a redox mediator solution that comprises a solvent and a redox mediator to form a redox mediator solution comprising alkali metal ions in a first tank, wherein the redox mediator has a reduction potential that is less than the reduction potential of the first active material and greater than the reduction potential of the second active material, such that the redox mediator reduces the first active material and oxidises the second active material, thereby releasing the alkali metal ions from the first and second active materials The redox mediator solution from step (b) of the method is then processed to allow capture of the alkali metal ions as an alkali metal hydroxide according to steps (c) to (e) as disclosed herein.
The present disclosure relates to a composition comprising an active agent and a drug carrier, wherein the drug carrier at least partially encapsulates the active agent, and wherein the molar ratio of the active agent to the drug carrier is between about 1:20 to about 1:40. The present disclosure also relates to a method of forming the composition as defined herein. There is also provided a method of of delivering the composition, a method of treating using the composition and medical uses of the composition as defined herein.
A61K 9/1271 - Liposomes non conventionnels, p. ex. liposomes modifiés par un PEG ou liposomes enduits de ou greffés avec des polymères
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
Trans-splicing RNA (tsRNA) The invention concerns a trans-splicing RNA (tsRNA) molecule comprising at least one or multiple unstructured target binding domains complementary to at least one or multiple precursor messenger RNA (pre-mRNA) targets and adapted to prevent off-target trans-splicing by the inclusion of a safety domain; a cell or vector or therapeutic or composition or pharmaceutical composition comprising said tsRNA; and a method for killing cells or treating a disease or for imaging or for a cosmetic application using said tsRNA. The invention has use in the medical, cosmetic, and veterinary field.
Various embodiments may relate to a cement mortar composition. The cement mortar composition may include cement, sand, and water. The cement mortar composition may also include iron phosphate dominated waste (FPW) mixed with the cement, the sand and the water. The iron phosphate dominated waste (FPW) may include iron oxide (Fe2O3) and phosphorus pentoxide (P2O5).
The present disclosure concerns a method of electrochemically halogenating an alkane and/or cycloalkane, comprising contacting a working electrode with an electrolyte; and applying a voltage or current to the working electrode; wherein the electrolyte is an emulsion comprising the alkane and/or cycloalkane in an oil phase and a halogen salt in an aqueous phase; wherein the working electrode comprises a catalyst, the catalyst comprises at least iridium.
C25B 3/11 - Composés contenant au moins un atome d’halogènes
C25B 11/091 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques
A spectrometer for detecting an electromagnetic (EM) wave spectrum having one or more wavelength components within a spectral band of interest, a method of detecting an electromagnetic (EM) wave spectrum having one or more wavelength components within a spectral band of interest, and a method of constructing the spectrometer. The method comprises the steps of creating dispersed images of an entrance aperture on a plane of an exit aperture, such that respective images at the different wavelength components are offset by different amounts of displacements along a direction of dispersion; gathering a first EM wave energy incident on the entrance aperture to an EM detector; gathering a second EM wave energy that exits the exit aperture to the at least one single-pixel detector; and measuring the output of the EM detector and the output of the at least one single pixel detector for reconstructing the EM wave spectrum taking into account an intensity distribution of an incident EM wave on the entrance aperture.
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
Inventeur(s)
Chew, Tec Kuan Paul
Koh, Teck Chang Victor
Aquino, Maria Cecilia Domingo
Abrégé
Described are optical probes for application of laser light to at least the pars plana and optionally other regions, such as the trabecular meshwork, pars plicata, and/or ciliary sulcus, of an eye, such as for treatment of glaucoma, to reduce intraocular pressure (IOP), to improve outflow of aqueous humor from the eye, and/or reduce buildup of aqueous humor within the eye. The optical probes can be adapted for simultaneously treating multiple different regions, tissues, or bodies of the eye, or for sequentially treating multiple different regions, tissues, or bodies of the eye.
A61F 9/009 - Dispositifs auxiliaires destinés à réaliser un contact avec le globe oculaire et un couplage de la lumière laser
A61B 18/22 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet
A61F 9/008 - Procédés ou dispositifs pour la chirurgie de l'œil utilisant un laser
90.
SYSTEMS AND METHODS FOR PRODUCING RETINAL PROGENITORS
Retinal progenitors and mature photoreceptor cells can be produced by differentiating human embryonic stem cells on a surface having a laminin matrix thereon made of two laminins. One laminin is laminin-521, and the other laminin is either laminin-323 or laminin-523. Stem cells plated on this substrate can be differentiated using various cell culture mediums to obtain the retinal progenitors and mature photoreceptor cells.
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
Inventeur(s)
Chew, Tec Kuan Paul
Koh, Teck Chang Victor
Aquino, Maria Cecilia Domingo
Abrégé
Described are optical probes for application of laser light to at least the pars plana and optionally other regions, such as the trabecular meshwork, pars plicata, and/or ciliary sulcus, of an eye, such as for treatment of glaucoma, to reduce intraocular pressure (IOP), to improve outflow of aqueous humor from the eye, and/or reduce buildup of aqueous humor within the eye. The optical probes can be adapted for simultaneously treating multiple different regions, tissues, or bodies of the eye, or for sequentially treating multiple different regions, tissues, or bodies of the eye.
A61F 9/009 - Dispositifs auxiliaires destinés à réaliser un contact avec le globe oculaire et un couplage de la lumière laser
A61F 9/008 - Procédés ou dispositifs pour la chirurgie de l'œil utilisant un laser
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
92.
MODULE AND METHOD FOR GENERATING A CONTROL INPUT FOR A NONLINEAR SYSTEM
This disclosure describes a computing module for reducing communication burden between a controller and a physical system comprising a non-linear system by which only a m-length string is transmitted between the controller and the physical system. Further, the computing module introduces a self-adjustable performance mechanism that flexibly adjusts symmetric or asymmetric performance boundaries of the nonlinear system to accommodate various type of initial conditions, providing a solution to an underlying tracking problem.
G05B 13/00 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé
G05B 15/00 - Systèmes commandés par un calculateur
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
Inventeur(s)
Panengad, Pradeep Paul
Unniyampurath, Unnikrishnan
Wang, Linfa
Dharmaraj, Rajesh Babu
Nambiar, Ajay Purushothaman
Anantharajan, Senthil Kumar
Naduparambil, Manoj Krishnan
Abrégé
The present disclosure concerns a wound debridement device, comprising scraping means, wherein at least a portion of the scraping means is configured to act as a first electrode; and a reservoir for containing a second electrode and an electrolyte, wherein the reservoir is configured to elute electrolyte onto a wound; wherein when in use, the first electrode is electrically connected to the eluted electrolyte on the wound, and the eluted electrolyte adjacent to the portion of the scraping means is ionised. The scraping means may be a blade, a brush, a mesh, a perforated disc or a wire loop.
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD (Singapour)
Inventeur(s)
Liau, Glen Zi Qiang
Ng, Matthew Song Peng
Abrégé
A system is described for a joint replacement procedure between bones. The 5 location and shape of the first bone and the second bone are determined in in three-dimensional space, movements of the joint are analysed to extract a set of maximum spacing parameters, and a set of initial parameters and a set of target gap parameters are obtained. The initial parameters are then iteratively changes between a minimum value and the corresponding maximum spacing 10 parameter, and all other initial parameters are calculated to produce a candidate set of parameters. The candidate set of parameters is then outputting if it complies with the set of target gap parameters. If desired, a robotic assistance device can then be controlled in accordance with the candidate parameters to support the joint replacement procedure.
Methods and systems for luminescence characterisation of semiconductor devices are provided herein In an embodiment, the method 300 for luminescence characterisation of a perovskite material 224 comprises a step 302 of exciting at least part of the perovskite material 224 with a modulated optical beam 210 to emit a modulated photoluminescence signal 226, the modulated optical beam 210 having a modulation frequency that is selected based on an estimated lifetime of the perovskite material 224 to be characterised; a step 304 of capturing the emitted modulated photoluminescence signal 226; and a step 306 of analysing a phase and/or modulation change between the modulated optical beam 210 and the modulated photoluminescence signal 226 for characterising the perovskite material 224.
This disclosure relates to methods of promoting infiltration of a nanoparticle-based anti-cancer drug into a solid tumor of a subject using mechanical stimulation. Devices for performing such a method are also disclosed. In one embodiment, the mechanical stimulation is a compressive force applied to the tumor or to a tissue surrounding the tumor, or to a tissue in the vicinity of the tumor. In another embodiment, the device comprises an actuator capable of providing mechanical stimulation to the solid tumor or to the tissue in the vicinity of the solid tumor when positioned at a proximate location from the tumor on an external skin surface.
A61H 23/04 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement hydraulique ou pneumatique
This disclosure relates to nucleic acid inhibitors, specifically small interfering RNA (siRNAs), of serine palmitoyltransferase long chain base subunit 2 (SPTLC2) and use thereof for treating fatty liver diseases. A lipid nanoparticle composition comprising the nucleic acid inhibitor and a pharmaceutically acceptable carrier is also provided.
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
There is provided a method of profiling a microbiotic composition of a sample comprising the nucleic acid molecules of the microbiotic composition, the method comprising a) partitioning the sample in a sufficient number of partitions such that at least a portion of the partitions comprises no more than one nucleic acid molecule of the microbiotic composition; b) contacting the partitions of the sample to a plurality of mismatch-tolerant probes that are capable of binding to the nucleic acid molecules or parts thereof under suitable conditions; c) determining signals generated by each of the plurality of mismatch-tolerant probes in each partition; and d) establishing the microbiotic composition in the sample based on the signals. Also disclosed is a method of determining a health and kits for uses in the methods as described herein.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
Disclosed is a method of treating LMNA Dilated Cardiomyopathy (DCM) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a first recombinant Adeno-associated virus (rAAV) encoding Lamin C (rAAV-Lamin C) and/or a second rAAV encoding Lamin A (rAAV-Lamin A), wherein the rAAV- Lamin C comprises a nucleotide sequence of SEQ ID NO:2 or SEQ ID NO: 4, and the rAAV-Lamin A comprises a nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
100.
SYSTEM AND METHOD OF TRIAGING SEPSIS PATIENTS USING HEART RATE N-VARIABILITY (HRnV)
Systems and methods for triaging sepsis patients by receiving a heart rate signal comprising a plurality of heartbeats from a patient, determining a value for each of a plurality of heart rate variability (HRV) parameters and each of a plurality of heart rate n-variability (HRnV) parameters from the heart rate signal and applying the predictive model to the values to determine a sepsis risk category for the patient from a plurality of sepsis risk categories.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/352 - Détection des crêtes de l'onde R, p. ex. pour la synchronisation d'appareils de diagnosticEstimation de l’intervalle entre crêtes R
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
