A system for managing liver disease including an electronic medical record system comprising a plurality of patient records. The system includes a patient management platform configured to access the electronic medical record (EMR) system to retrieve medical records of one or more patients, analyze the medical records to selectively identify data relating to liver condition(s), interface with one or more data analytics platform(s), the data analytics platform(s) configured to receive and analyze the data relating to liver-conditions. Based on the analyzing by the patient management interface and/or the data analytics platform(s), generating a display including specific liver-related patient attributes and conditions, and at least one of a liver-health prognosis or recommended treatment for addressing the liver condition(s) respective to the one or more patients. The liver conditions may include one or more of: cancer, cirrhosis, liver failure, fatty liver disease, steatosis, ischemia, and/or hepatitis.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 20/00 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
2.
Compositions and Methods for Detecting Carbapenem Resistant Acinetobacter calcoaceticus -Acinetobacter baumannii (CRAB)
The present invention relates to compositions and methods to detect the Acinetobacter calcoaceticus-Acinetobacter baumannii complex species and to identify the most prevalent carbapenemases found in carbapenem resistant Acinetobacter calcoaceticus-baumannii (CRAB) such as blaOXA-23-like, blaOXA-24-like, blaOXA-58-like and blaNDM-like by a multiplex real-time PCR assay.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
The present invention provides compositions and methods relating to novel digital PCR (dPCR) assay designs (droplet digital or other systems) for the detection and quantitation of multiple hepatitis B virus (HBV) gene targets. The compositions and method can further include non-extendible blocker oligonucleotides for reduction of non-specific inter-amplicon extension.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
Disclosed are novel modified DNA polymerases having improved reverse transcriptase efficiency, improved specificity, increased mismatch tolerance, increased extension rate, and increased tolerance of inhibitors of reverse transcription (RT) and polymerase, relative to a corresponding, unmodified polymerase. These novel modified polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the novel modified DNA polymerases.
The present disclosure provides efficient methods for production, purification and deprotection of RNA molecules, as well as compositions relating thereto. A method for removing 2'-O protecting groups from RNA molecules is disclosed, comprising removing the 2'-O protecting groups by exposure to a composition comprising tetrabutylammonium fluoride (TBAF) hydrate in DMSO. In this context, the disclosure provides means for precipitating 2'-O protected RNA molecules, as well as means for 2'-O deprotection of RNA molecules, using amine scavengers if necessary to reduce RNA cross-links arising from deprotection.
C07H 1/00 - Procédés de préparation des dérivés du sucre
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
C07H 23/00 - Composés contenant du bore, du silicium ou un métal, p. ex. chélates ou vitamine B12
A navigable directed graph interface representing a medical guideline, wherein the medical guideline includes a decision tree including a plurality of clinical decisions and preconditions. The navigation interface presents a portion of the directed graph based on a sequence of recorded preconditions and/or clinical decisions of the medical guideline and a portion of the directed graph diverging from the sequence of recorded preconditions and/or clinical decisions. The diverging portion of the directed graph is graphically distinguished from the portion of the directed graph based on the recorded preconditions and/or clinical decisions. In response to receiving a selection of an alternate node from the diverging portion of the directed graph, the graphical representation of the directed graph displays one or more child nodes of the selected alternate node.
G16H 70/20 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des pratiques ou des directives
G06F 3/0482 - Interaction avec des listes d’éléments sélectionnables, p. ex. des menus
G06F 3/04845 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] pour la commande de fonctions ou d’opérations spécifiques, p. ex. sélection ou transformation d’un objet, d’une image ou d’un élément de texte affiché, détermination d’une valeur de paramètre ou sélection d’une plage de valeurs pour la transformation d’images, p. ex. glissement, rotation, agrandissement ou changement de couleur
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
7.
SYSTEMS AND METHODS FOR ASSESSING BAYS ON DIAGNOSTIC DEVICES
Disclosed are methods, systems and apparatuses in which a diagnostic instrument analyzes data collected over time, and based on that information, disables a bay, suggests a bay, puts a bay on standby or combinations thereof. In some embodiments, the method, system and apparatus allows the diagnostic instrument to have higher validity rates in the field and allows the provider to set up service calls, schedule maintenance and perform remote maintenance, as well as other functions based on the data collected over time.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p. ex. pour planifier la maintenance ou les mises à jour
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
8.
PROGNOSIS PREDICTION FOR ST-SEGMENT-ELEVATION MYOCARDIAL INFARCTION (STEMI) PATIENTS
Methods of providing a prognosis for a patient who has been treated for ST-segment-elevation myocardial infarction (STEMI) are provided The methods comprise: receiving the values of a plurality of predetermined features associated with the patient, the predetermined features comprising: one or more patient demographic features, one or more hospital admission history features, one or more clinical history features, one or more vital signs features and/or one or more laboratory tests features; and predicting, using the values of said plurality of features, a prognosis for the patient, wherein said predicting comprises using one or more machine learning models to predict a risk of the patient experiencing one or more respective post-treatment complications.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
The present disclosure provides for devices, compositions, and methods for improving signal variability in electrochemical detection, such as electrochemical detection with a biochip, such as a biochip including a gold electrode.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
10.
TANDEM ISOTHERMAL AMPLIFICATION AND POLYMERASE CHAIN REACTION
The present disclosure is directed to methods of amplifying one or more nucleic acid molecules. In particular, the methods of the present disclosure utilize a combination of (i) one or more isothermal amplification techniques, and (ii) polymerase chain reaction. The methods of the present disclosure comprise performing an isothermal amplification for a predetermined amount of time at a predetermined temperature; and subsequently performing a predetermined number of PCR cycles.
The present disclosure relates, in general, to a method of detecting at least one viral target in a sample and, more particularly, to improved methods and compositions for single and multiplex detection by PCR of one or more arthropod-borne virus.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
12.
DEVICES AND APPLICATIONS OF COUPLED NUCLEIC ACID AMPLIFICATION TESTS AND CRISPR SYSTEMS
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
13.
UTILIZATION OF dITP FOR PREFERENTIAL/SELECTIVE AMPLIFICATION OF RNA VERSUS DNA TARGETS BASED ON STRAND-SEPARATION TEMPERATURE
Methods for preferentially and/or selectively detecting and/or quantitating target RNA, over DNA, in a biological or non-biological sample are described. The methods include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, the reaction mixture includes dNTPs, that include dITP. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the preferential and/or selective amplification and detection and/or quantitation of target RNA (over DNA), in the presence of dITP. The methods, kits, and reaction mixtures are for the preferential and/or selective detection and/or quantitation of RNA, over DNA, and are particularly useful with samples that comprise a number of different types of nucleic acids (e.g., DNA and RNA).
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable software for use therewith sold as a unit
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for testing body fluids to determine fetal chromosomal abnormalities; chemical reagents, preparations and test kits for fetal nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis
16.
COMPOSITIONS AND METHODS FOR DETECTING LYMPHOGRANULOMA VENEREUM (LGV) SEROVARS OF CHLAMYDIA TRACHOMATIS
The present disclosure relates, in general, to the methods for the rapid detection of the presence or absence of Lymphogranuloma Venereum (LGV)-causing serovars of Chlamydia trachomatis in a biological or non-biological sample. The methods can include performing an amplification step, a hybridization step, and a detection step. Furthermore, oligonucleotide primers and probes targeting the pmpH gene for the L serovars of Chlamydia trachomatis, along with kits are provided that are designed for the detection of L serovars.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
Methods of identifying an immunophenotype for a tumour are described, using one or more whole slide images of a sample of the tumour that has been stained using at least a CD8 label Related methods and systems are also described.
G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
The present disclosure relates, in general, to novel and easily accessible fluorescent compounds with improved fluorescence properties for expanding the multiplexing capabilities of fluorescence-based nucleic acid detection technologies, as well as to novel methods of producing the same. Moreover, conjugates, PCR probes and FRET pairs comprising these fluorescent compounds as well as methods for amplification and detection of a target nucleic acid utilizing these fluorescent compounds and methods of labeling are also provided.
C09B 11/06 - Dérivés hydroxylés de triarylméthanes dans lesquels un groupe —OH au moins est lié à un noyau aryle
C09B 23/01 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
A slide imaging apparatus includes: at least one imaging device configured to generate an image of a sample mounted on a slide, wherein the imaging device comprises an operating button; a storage device loadable with a plurality of slides and configured to store the slides; and a supply device configured to supply the slides from the storage device to the imaging device, wherein the supply device is configured to press the operating button.
Methods for the rapid detection of the presence or absence of Monkeypox Virus (MPXV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the MPXV F3L gene and the MPXV B21R gene, along with kits are provided that are designed for the detection of MPXV.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
A system for managing heart disease, the system including a patient management platform for managing heart disease in patients, the patient management platform connected with one or more mobile and remote patient monitoring device(s) configured to remotely obtain patient physiological attributes outside of a clinic or hospital setting. The patient management platform is configured to receive patient data through electronic patient data systems (e g., an EMR) and compare the physiological attributes and patient data with at least one heart disease treatment protocol. Based on the analyzing, the platform determines one or more recommended action(s) to be taken according to at least one heart disease treatment protocol and generates a notification of the recommended action(s).
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
The present invention relates to methods to improve detection of amplification products from Loop-mediated Amplification (LAMP) reactions by the use of nucleotide analogs that form duplex structures that nucleic acid polymerase enzymes do not recognize efficiently.
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
The present disclosure relates, in general, to novel and easily accessible fluorescent compounds with large Stokes shift (LSS) and thermostable fluorescence for expanding the multiplexing capabilities of fluorescence-based nucleic acid detection technologies. Moreover, conjugates, probes and FRET pairs comprising these fluorescent compounds as well as methods for amplification and detection of a target nucleic acid utilizing these fluorescent compounds and methods of labeling are also provided.
C09B 11/24 - Phtaléines contenant des groupes amine
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
25.
FERROCENE LABELLED PRIMERS FOR ELECTROCHEMICAL DETECTION
The present invention provides novel primers in which a ferrocene label is attached to the primer. The ferrocene label is incorporated into the amplification product. When the amplification product incorporating the ferrocene label is denatured, it can bind to a capture probe and the presence or absence of the ferrocene label can be detected via electrochemical detection. The system avoids the use of a signal probe in a sandwich assay as historically used during electrochemical detection.
C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
C12Q 1/6853 - Réactions d’amplification d’acides nucléiques utilisant des amorces ou des matrices modifiées
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
The present disclosure is directed to compositions, kits, and methods for identifying one or more immunotherapy resistant mutations in a nucleic acid sample obtained from a subject, such as a subject in need of treatment with one or more targeted immunotherapeutic agents. In some embodiments, the present disclosure is directed to compositions, kits, and methods of target enrichment by unidirectional primer extension, whereby the compositions, kits, and methods include one or more target capture primers designed for the selective enrichment of one or more genes encoding one or more proteins targeted or capable of being targeted with an immunotherapeutic agent.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
e.g.e.g. a bacteriophage) in a sample, to determine a host range of a bacteriophage of interest, and to determine a phagogram of a bacterium of interest.
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
29.
MULTI-MODAL MACHINE LEARNING APPROACHES FOR PREDICTING CANCER TYPE AND GLEASON GRADE LEVERAGING PUBLIC TCGA DATA
The invention relates to a method of diagnosing or determining the prognosis of cancer in a patient, the method comprising processing, using RNA-sequencing and a first machine learning model, the genomic data of the patient to determine at least one of a first cancer type or degree of cancer and processing, using histopathology and a second machine learning model, the biopsy image data of the patient to determine at least one of a second cancer type or degree of cancer and comparing the determined first type or degree of cancer with the determined second type or degree of cancer and correlating the two.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
A method for autonomous teach-in of at least one target position of a supply device (120) of a slide imaging apparatus (110) is disclosed. The slide imaging apparatus (110) comprises at least one imaging device (126, 128) configured to generate an image of a sample mounted on a slide (140). The target position is a position on the imaging device (126, 128). The slide imaging apparatus (110) comprises at least one operating system (170) configured for controlling operation of the supply device (120). The method comprises the following steps
i) (186) providing at least six pre-defined positions by using the operating system (170);
ii) (188) driving the supply device (120) to the six pre-defined positions until colliding with the imaging device (126, 128) by using the operating system (170) and detecting collisions with the imaging device (126, 128);
iii) (190) evaluating the detected collisions by using the operating system (170), thereby determining the target position.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
31.
MUTANT DNA POLYMERASE(S) WITH IMPROVED STRAND DISPLACEMENT ABILITY
Disclosed are DNA polymerases having increased 5′-3′ strand displacement activity and substantially reduced 5′-3′ exonuclease and endonuclease activity relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
Described herein are methods for pipetting liquids using a pipet comprising a disposable pipet tip having a filter using pressure data calibration for improved pipetting surveillance sensitivity and/or identifying defective pipets.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
33.
METHOD OF INCREASING THE NUMBER OF USABLE CHANNELS IN MULTIPLEX PCR
Methods and systems are disclosed for performing a multiplex PCR to determine first and second target polynucleotides in a sample. The method includes (i) contacting the sample in a single container with a first probe oligonucleotide for the first target and with a second probe oligonucleotide for the second target. The first probe is labeled with a first label emitting a first label signal in a first channel, a first crosstalk signal in a second channel, and a second crosstalk signal in a third channel. The second probe is labeled with a second label emitting a second label signal in the third channel. The method further includes (ii) amplifying target polynucleotides by PCR, (iii) measuring a multitude of values in the second and third channels 10 over at least part of the amplification in step (ii), and (iv) determining the first target polynucleotide based on the values measured in step (iii).
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
G16B 25/20 - Réaction en chaîne par polyméraseConception d’amorces ou de sondesOptimisation de la sonde
34.
GRIPPING DEVICE CONFIGURED FOR GRIPPING AT LEAST ONE SLIDE
A gripping device configured for gripping at least one includes: at least one first gripping element including at least one first contact surface for gripping the slide; at least one second gripping element, wherein the second gripping element comprises at least one second contact surface for gripping the slide, wherein the second gripping element further comprises at least two protrusions which respectively extend essentially perpendicular to the second contact surface, wherein the at least two protrusions are located on opposing ends of the second contact surface, wherein the at least two protrusions are configured for centering the slide during gripping the slide via the gripping device; wherein the first gripping element and the second gripping element are linearly movable relative to one another, wherein the first contact surface of the first gripping element and the second contact surface of the second gripping element face each other.
B01L 9/00 - Dispositifs de supportDispositifs de serrage
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
e.g..i.e.e.g.e.g., inhibited signaling enzyme activity. When a target is present in the reaction mix, the Cas/guideRNA system becomes activated and preferentially collaterally cleave(s) all nucleic acids in the solution, including the aptamer. Once aptamer gets cleaved, the signaling enzyme is free to produce a signal. In the presence of a substrate, such signaling enzyme activity produces a robust signal that significantly improves the limit-of-detection of other techniques in the art.
The present disclosure relates to enzymatic cascade reactions for achieving better sensitivity in detecting a target nucleic acid sequence. Several aspects of the disclosure relate to a reaction master mix comprising four major components: a CRISPR enzyme, a guide RNA (gRNA), an aptamer (e.g., an inhibiting aptamer or an activating aptamer) and a “signaling” (i.e., reporter) enzyme. The aptamer interacts with the signaling enzyme and forms a complex, resulting in, e.g., inhibited signaling enzyme activity. When a target is present in the reaction mix, the Cas/guideRNA system becomes activated and preferentially collaterally cleave(s) all nucleic acids in the solution, including the aptamer. Once aptamer gets cleaved, the signaling enzyme is free to produce a signal. In the presence of a substrate, such signaling enzyme activity produces a robust signal that significantly improves the limit-of-detection of other techniques in the art.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/28 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une oxydoréductase une peroxydase
C12Q 1/44 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase une estérase
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
The present disclosure is directed to a thermal unit for a device for thermal cycling, also referred to as thermocycling, of a plurality of biological samples simultaneously, to such device itself, and also to a method for thermal cycling a plurality of biological samples simultaneously using such device and thermal unit.
A system for quality control of a medical device or software product including a plurality of quality control (QC) modules, each QC module configured for one or more QC task(s) of a QC process and configured for access by a plurality of users assigned roles and responsibilities for the respective QC task(s), the quality control library configured to store a plurality of QC records including information associated with the QC task(s) and governmental rule(s) or regulation(s) applicable to the respective QC module and medical device product.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
G06Q 10/0639 - Analyse des performances des employésAnalyse des performances des opérations d’une entreprise ou d’une organisation
G06Q 30/018 - Certification d’entreprises ou de produits
42.
SYSTEMS AND METHODS OF NOVEL CRISPR-CAS PROTEINS FOR IN-VITRO APPLICATIONS
The present disclosure relates to novel CRISPR enzymes, reaction mixtures, methods of using the same in the detection of microorganisms, such as FluA, FluB, amongst others. The disclosure particularly relates to the discovery of novel functional CRISPR enzyme complexes, particularly systems displaying trans cleavage activity.
Methods for the rapid detection of the presence or absence of SARS-CoV-2, influenza A and influenza B in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting SARS-CoV-2, influenza A, and influenza B and kits are provided that are designed for the detection of SARS-CoV-2, influenza A and influenza B.
C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
The present disclosure relates to performing endpoint genotyping based on a Gaussian mixture model (GMM). As one example, a method includes: obtaining, using a processor, cross-talk corrected fluorescent PCR data for an assay; determining, using the processor, a plurality of values based on the cross-talk corrected fluorescent PCR data; generating, using the processor, an assay based on the plurality of values; determining, using the processor, a genotype of a sample based on one or more gray-zones and at least one value associated with the sample; and displaying the genotype determination on a user display.
The present disclosure relates to novel CRISPR enzymes, reaction mixtures, methods of using the same in the detection of microorganisms, such as FluA, FluB, amongst others. The disclosure particularly relates to the discovery of novel functional CRISPR enzyme complexes, particularly systems displaying trans cleavage activity.
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; medical instruments being quantitative polymerase chain reaction (PCR) instrument for scientific use; scientific equipment, apparatus and instruments, namely, genome sequencers for scientific, pharmaceutical and medical research purpose being detecting genetic sequences; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, all for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Scientific research in the field of genome sequence analysis and reporting; medical research in the field of genome sequence analysis and reporting; dna screening for scientific research purposes; providing reagent sample testing services for others in the fields of science and scientific research; computer services, namely, hosting an interactive web site that allows users to store, analyze and share data in the field of life science; technical support services, namely, infrastructure management services for monitoring, administration and management of cloud computing it and application systems in the field of life science; providing temporary use of online non-downloadable software for the custom design and ordering of assays and reagents; installation and maintenance of computer software and database systems used in the field of analysis of biomolecules; consultancy, information and advisory services in the field of scientific analysis of biomolecules; clinical diagnostic services in preparing, amplifying, labeling, detecting, analyzing and sequencing nucleic acids and other biological molecules from human beings or animals for scientific and medical research purposes; scientific consulting and research services and clinical laboratory testing services in the fields of amplification, detection, sequencing and analysis of nucleic acids and the preparation of nucleic acid libraries; nucleic acid sequencing services for scientific research purposes; scientific research, namely, computational analysis of nucleic acid sequences and development of computational technologies for the analysis of nucleic acid sequences
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for genetic testing; chemical reagents, preparations and test kits for nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable software for recording, processing and transmitting medical data, for use therewith, sold as a unit
48.
SYSTEMS AND METHODS FOR ANALYZING A MULTI-WELL PLATE
The disclosure is related to analyzing multi-well plates. The method includes analyzing, using a machine learning model, a sample inserted in an analyzer to determine whether a plate insert matches a multi-well plate (MWP). The method further includes, in response to the machine learning model a mismatch between the plate insert and MWP, generating an alert on the analyzer to notify a user indicating the mismatch. The method also includes, in response to the machine learning model determining that the plate insert matches the MWP, analyzing, using the machine learning model, the sample to determine whether the MWP is sealed with a foil. The method includes, in response to the machine learning model determining that the MWP is not sealed with foil, generating the alert on the analyzer, and otherwise, enabling the analyzer to perform its analysis of the sample.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
A collaboration platform is provided to analyze one or more biomedical data sets. The collaboration platform may include a project management engine, a data ingestion engine, and a data analysis engine. The project management engine may generate a plurality of project environments for analyzing biomedical data sets of interest, and designate a set of authorized users with access to given project environments. The data ingestion engine may process data sets and store them in a central data storage system for access within the project environments. The data analysis engine may perform analyses and special computing on the ingested data and generate updated output data that may be re-ingested for further analyses in the project environments.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
G06F 21/62 - Protection de l’accès à des données via une plate-forme, p. ex. par clés ou règles de contrôle de l’accès
50.
STRUCTURED DATA CAPTURE, AGGREGATION, AND ANALYSIS OF CLINICAL CHARACTERISTICS OF PATIENTS IN A LIVER DISEASE DIAGNOSTIC SETTING
A system for managing liver disease including an electronic medical record system comprising a plurality of patient records. The system includes a patient management platform configured to access the electronic medical record (EMR) system to retrieve medical records of one or more patients, analyze the medical records to selectively identify data relating to liver condition(s), interface with one or more data analytics platform(s), the data analytics platform(s) configured to receive and analyze the data relating to liver-conditions. Based on the analyzing by the patient management interface and/or the data analytics platform(s), generating a display including specific liver-related patient attributes and conditions, and at least one of a liver-health prognosis or recommended treatment for addressing the liver condition(s) respective to the one or more patients. The liver conditions may include one or more of: cancer, cirrhosis, liver failure, fatty liver disease, steatosis, ischemia, and/or hepatitis.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
51.
COMPUTER IMPLEMENTED METHOD FOR PERFORMANCE VERIFICATION OF A THERMAL BLOCK CYCLER UNIT
A computer-implemented method for performance verification of a thermal block cycler unit for automated thermal treatment of at least one sample is described. The thermal block cycler unit includes at least one thermal block configured for receiving at least one sample vessel, and a plurality of hardware modules. The hardware modules include a plurality of heating and/or cooling elements and at least one temperature sensor. The method includes consecutively functional testing the hardware modules, and defining the order of tests by using a thermal energy of its preceding test and/or a status of the thermal block cycler unit of its preceding test, and balancing energy consumption between the steps to minimize a difference between an input temperature before consecutively testing the hardware modules and an output temperature after consecutively testing the hardware modules.
A federated analytics (FA)/federated learning (FL) system configured to implement a federated learning pipeline or a federated analytics pipeline comprises: a centralized FA/FL platform comprising a client environment interface module; and a plurality of local environments, each local environment comprising a respective local memory configured to store local raw data and/or local pre-processed data. The local environments are configured to obtain data from data sources, and to generate local statistical models which are aggregated at the centralized platform to generate a global statistical model, thereby fulfilling a client request.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Chemical, biological and biochemical preparations for scientific purposes and for research purposes; in vitro diagnostic reagents for use in research and science; chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; chemical reagents for diagnostic tests and test kits for the determination of genetic information for scientific or research purposes; assays and reagents for use in genetic research; reagents and nucleotides for the sequencing of nucleic acids for scientific or research purposes
54.
AUTOMATED INFORMATION EXTRACTION AND ENRICHMENT IN PATHOLOGY REPORT USING NATURAL LANGUAGE PROCESSING
In one example, a method being performed by a computer system comprises: receiving an image file containing a pathology report; performing an image recognition operation on the image file to extract input text strings; detecting, using a natural language processing (NLP) model, entities from the input text strings, each entity including a label and a value; extracting, using the NLP model, the values of the entities from the input text strings; converting, based on a mapping table that maps entities and values to pre-determined terminologies, the values of at least some of the entities to the corresponding pre-determined terminologies; and generating a post-processed pathology report including the entities detected from the input text strings and the corresponding pre-determined terminologies.
G06V 30/30 - Reconnaissance de caractères fondée sur le type de données
G06V 30/416 - Extraction de la structure logique, p. ex. chapitres, sections ou numéros de pageIdentification des éléments de document, p. ex. des auteurs
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
55.
METHODS AND DEVICES FOR MANAGING INFORMATION DEALING WITH A MEDICAL TEST FOR ASSESSING A PREDETERMINED MEDICAL CONDITION
The invention relates to a method for managing information dealing with a medical test for assessing a predetermined medical condition by means of a distributed system (100) comprising a plurality of communication devices (210, 312, 322, 410), the method comprising obtaining by a user communication device (210) information on an access code provided in a test-kit for assessing a predetermined medical condition, the user communication device (210) being configured for receiving and displaying messages addressed to a unique identifier. Further, the method comprises providing instructions relating to analysis of the medical sample. A negative analysis result is communicated to the user communication device (210) of the user. In case of a positive analysis result, consultation by a medical entity is established. Further aspects relate to a user communication device, a computer program product, a central server and a medical test-kit for use with the proposed method.
G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 50/80 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la détection, le suivi ou la modélisation d’épidémies ou des pandémies, p. ex. de la grippe
A navigable directed graph interface representing a medical guideline, wherein the medical guideline includes a decision tree including a plurality of clinical decisions and preconditions. The navigation interface presents a portion of the directed graph based on a sequence of recorded preconditions and/or clinical decisions of the medical guideline and a portion of the directed graph diverging from the sequence of recorded preconditions and/or clinical decisions. The diverging portion of the directed graph is graphically distinguished from the portion of the directed graph based on the recorded preconditions and/or clinical decisions. In response to receiving a selection of an alternate node from the diverging portion of the directed graph, the graphical representation of the directed graph displays one or more child nodes of the selected alternate node.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 15/00 - TIC spécialement adaptées aux rapports médicaux, p. ex. leur création ou leur transmission
G16H 70/20 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des pratiques ou des directives
57.
METHOD FOR CLUSTERING MELTING CURVES TO IDENTIFY GENOTYPES
Automated methods for genotyping melting curves are described. Melting curves are processed and difference matrices are compiled based on the processed matrices. The difference matrices are used to compile a cluster matrix and the cluster matrix is filtered to determine clusters that are used for genotyping the melting curves.
The present invention provides for novel methods and compositions for nucleic acid sequence detection. Unique, identifying positively charged tags from oligonucleotide probes, bound to target nucleic acids, are produced during PCR by the 5′-nuclease activity of the polymerase. The identity of the targets can be determined by identifying the unique positively charged tags.
Provided is a method and apparatus for communicating with Laboratory Information Systems (LIS). Specifically disclosed is a method and apparatus having unique message formatting for different laboratory areas. To accomplish this, the diagnostic instrument can form multiple connections with a single LIS. Each connection is customized with a set of configuration parameters, which can include a communication protocol, connection method, relevant information, and/or result formatting. Thus, disclosed is a diagnostic instrument that can communicate results to multiple different LIS Environments. Thus, disclosed is a diagnostic instrument comprising a LIS Interchange Manager (LIM).
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 15/00 - TIC spécialement adaptées aux rapports médicaux, p. ex. leur création ou leur transmission
61.
CELL CLASSIFICATION USING CENTER EMPHASIS OF A FEATURE MAP
Techniques described herein include, for example, generating a feature map for an input image, generating a plurality of concentric crops of the feature map, and generating an output vector that represents a characteristic of a structure depicted in a center region of the input image using the plurality of concentric crops. Generating the output vector may include, for example, aggregating sets of output features generated from the plurality of concentric crops, and several methods of aggregating are described. Applications to classification of a structure depicted in the center region of the input image are also described.
G06V 10/77 - Traitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source
G06V 10/80 - Fusion, c.-à-d. combinaison des données de diverses sources au niveau du capteur, du prétraitement, de l’extraction des caractéristiques ou de la classification
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
62.
COMPUTER-IMPLEMENTED METHOD FOR PERFORMING A CLINICAL PREDICTION
A computer-implemented method for performing a clinical prediction is disclosed. The method comprises the following steps: i) (110) retrieving input data via at least one communication interface (164) of a processing device (166), wherein the input data comprises multiple different modalities of a patient: ii) (114) processing the input data by using the processing device (166), wherein the processing comprises generating embedding modality representations from the input data by using at least one trainable data embedder, wherein the processing comprises combining the embedding modality representations using at least one aggregation network thereby generating the clinical prediction, wherein the aggregation network comprises at least one attention layer and/or at least one transformer layer; and iii) (118) generating an output of the clinical prediction by using the processing device (166).
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
63.
LABORATORY SYSTEM WITH INCREASED CONTROLS HANDLING AND METHOD FOR INCREASING CONTROLS HANDLING IN A LABORATORY SYSTEM OR DEVICE
A laboratory system or device comprising a control unit for controlling operation of the system or device, and a storage unit connected to the control unit and containing instruction for each assay type of the control type to be used when running said assay type, and, for each control type, an allocation rule for the control type. The control unit receiving at least one assay order comprising instructions to run at least one assay type on the system or device, determining for the at least one assay type comprised in the at least one assay order, the control type to be used, and the corresponding allocation rule for said control type, scheduling an assay run comprising instructions to include the determined control type based on the determined allocation rule, and controlling the system or device to perform the scheduled assay run.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
64.
MATERIALS AND METHODS FOR DETERMINING GAIN OR LOSS OF MRNA TRANSCRIPTS
Methods of evaluating mRNA or cDNA are provided. Instead of evaluating the mRNA or cDNA as a whole, multiple distinct portions of the mRNA or cDNA (such as different exons or untranslated regions) are separately quantified. The separate quantities are then evaluated by a trained classifier, which converts the separate quantities to a composite score indicative of the expression level of the mRNA or corresponding cDNA.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
G16B 25/00 - TIC spécialement adaptées à l’hybridationTIC spécialement adaptées à l’expression de gènes ou de protéines
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
65.
METHOD FOR CONTROLLING AN ANTI DROPLET SYSTEM OF A PIPETTOR AND PIPETTOR WITH ANTI DROPLET SYSTEM CONTROL
A method for controlling a laboratory system or device comprising at least one pipettor with a pressure sensor, at least one humidity sensor, at least one temperature sensor, and a control unit. The control unit receiving a humidity value from the humidity sensor and a temperature value from the temperature sensor, comparing the pair of humidity and temperature values with a threshold database connected to the control unit, the threshold database comprising, for different pairs of humidity and temperature values, instructions to activate or deactivate an anti droplet control system of the pipettor, determining if the anti droplet system of the pipettor has to be activated or deactivated, activating or deactivating said anti droplet system of the pipettor.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
Disclosed herein are techniques for facilitating a clinical decision for a patient based on identifying a group of patients having similar attributes as the patient. The group of patients can be identified using information from a predictive machine learning model that performs a clinical prediction for the patient. At least some of the attributes of the group of patients can be output to support a clinical decision. The attributes may include, for example, biography data of the patient, results of one or more laboratory tests of the patient, biopsy image data of the patient, molecular biomarkers of the patient, a tumor site of the patient, and a tumor stage of the patient.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
67.
LABORATORY SYSTEM OR DEVICE WITH IMPROVED SECURITY FEATURES AND METHOD FOR IMPROVING SECURITY IN A LABORATORY SYSTEM OR DEVICE
A method for increasing operational security of a laboratory system or device comprising: a reagent storage area (1) comprising at least two reagent drawers (2, 3) mounted slidably along a first axis Y between an open position (O) and a closed position (C) and arranged stacked with respect to a second axis Z perpendicular to the first axis Y, and having each a position sensor (P2, P3) for determining the closed position (C) of the respective reagent drawer (2, 3), at least one robotic handler head (4) movably arranged in the reagent storage area at least along the first axis Y and the second axis Z a control unit (5) configured to control the operation of the robotic handler head (4) and connected to the position sensors (P2, P3), the method comprising the steps of defining for each reagent drawer (2, 3) a first forbidden zone along the first axis Y (Y) and a second forbidden along the second axis Z (Z2, Z3), determining by means of the position sensors (P2, P3) if the reagent storage drawers (2, 3) are in the closed position (C), and control the operation of the handler head (4).
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
68.
Compositions and Methods for Detecting vanA and/or vanB Genes Associated with Multidrug Resistance
Methods for the rapid detection of the presence or absence of bacteria having the vanA and/or vanB resistance mechanisms in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the genes for vanA and vanB, along with kits are provided that are designed for the detection of vanA and vanB.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
A computer implemented method for designing a complex part of an in-vitro diagnostic instrument is disclosed. The method includes retrieving at least one target constraint, retrieving at least one set of input parameters, determining at least one design solution of the complex part by using at least one iterative algorithm considering the input parameters, comparing the candidate complex part to the target constraint, and rating the candidate complex part depending on the comparison.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G06F 30/23 - Optimisation, vérification ou simulation de l’objet conçu utilisant les méthodes des éléments finis [MEF] ou les méthodes à différences finies [MDF]
G06F 111/06 - Optimisation multi-objectif, p. ex. optimisation de Pareto utilisant le recuit simulé, les algorithmes de colonies de fourmis ou les algorithmes génétiques
A machine learning and/or deep learning framework forecasts epidemic or pandemic cases and deaths. Multiple open data sources relevant for the pandemic or epidemic evolution in a geographic area, such as the United States or another country or region, can be processed to extract a plurality of features, such as localized (i.e., county level, city level, regional level, province level, etc.) cases and deaths, demographics and socioeconomic factors, non-medical interventions, and mobility (i.e., from cell phone and/or GPS data). The learning can be used to predict future cases and deaths at localized levels and to recommend healthcare resources that may be needed.
G16H 50/80 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la détection, le suivi ou la modélisation d’épidémies ou des pandémies, p. ex. de la grippe
A method for controlling an anti droplet system of a laboratory system or device comprising at least one air displacement pipettor with a pressure sensor and a control unit for controlling operation of the pipettor, the method comprising the following steps controlling the pipettor to be moved such that the pipettor tip is immerged in a fluid to be aspirated, aspirate a predetermined volume of fluid, move the pipettor such that the pipettor tip is emerged from the fluid, continuously monitoring the pressure above the fluid column in the pipettor tip and generating pressure curve over time, and determining if a pressure increase above the fluid column has been detected.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
72.
LABORATORY SYSTEM OR DEVICE WITH IMPROVED REAGENT HANDLING AND METHOD FOR IMPROVING REAGENT HANDLING IN A LABORATORY SYSTEM OR DEVICE
A laboratory system or device, comprising a reagent storage area (1) comprising at least two reagent drawers (2, 3) mounted slidably between an open position (O) and a closed position (C), each of the reagent drawers comprising receptacles for a plurality of reagent cartridges (RC1, RC2), and at least two locking mechanisms (4, 5) for respectively locking/unlocking the at least two reagent drawers (2, 3) when in the closed position (C), at least one robotic handler (6) and a control unit (7), wherein the reagent storage area (1) is subdivided in a loading zone (LZ), a storage zone (SZ) and a pipetting zone (PZ), and the reagent storage area (1) further comprises a handling zone (HZ).
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
Methods for the rapid detection of the presence or absence of Malaria parasites (including Plasmodium) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Additionally, the assay can be a multiplex assay, to amplify and detect a plurality of Plasmodium targets simultaneously, which offers advantages over singleplex assays. Furthermore, primers and probes targeting Malaria parasites (including Plasmodium) and kits are provided that are designed for the detection of Plasmodium, including, but not limited to, the Plasmodium species of P. falciparum, P. vivax, P. ovale, P. knowlesi, and P. malariae. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of Malaria parasites (including Plasmodium).
C12Q 1/6893 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les protozoaires
74.
Tube tray for secondary tubes, secondary tube handling module, and method of handling secondary tubes in an automated processing system
The present invention describes a secondary tube tray for use in an automated processing system, the tray comprising a base module and a secondary tube insert. Furthermore, the present invention describes a secondary tube handling module of an automated processing system for automatically processing biological sample, and a method of handling secondary tubes for use in automatically processing biological sample in an automated processing system.
The present disclosure is concerned with data evaluation tools, methods for analyzing a dataset, and a computer readable medium comprising a computer program code that when run on a data processing device carries out the method of the disclosure as well as a device for carrying out the method of the disclosure. The methods and devices disclosed herein are used in analytical systems that analyze biological samples.
G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase
G06F 16/28 - Bases de données caractérisées par leurs modèles, p. ex. des modèles relationnels ou objet
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
A microfluidic device for thermocycling of a reaction mixture is provided. The device comprises an inlet opening, an outlet opening, a flow channel connecting the inlet opening and the outlet opening and defining a flow direction from the inlet opening through the flow channel to the outlet opening, wherein the flow channel comprises a first flow channel surface and a second flow channel surface opposite to the first flow channel surface, and an array of wells provided in the first flow channel surface for fluidic communication with the inlet opening and the outlet opening. Further, the first flow channel surface provides a first hydrophilicity and at least a part of the second flow channel surface provides a second hydrophilicity, wherein the first hydrophilicity is greater than the second hydrophilicity.
Disclosed is a dual-labeled signal probe comprising an electron transfer moiety (ETM) and an optical signaling moiety (OSM). Upon binding of a target analyte to the signal probe, the composition is transported to an electrode surface. In some embodiments, the ETM and OSM are then each excited by applying an electrical voltage to the electrode. In some embodiments, the ETM signal and OSM signal are then detected using a single detector (or more than one detector), allowing the presence or absence of the target analyte to be determined. In some embodiments, the ETM signal and OSM signal are correlated before determining the presence or absence of the target analyte. In some embodiments, the dual-labeled signal probe permits real-time detection using an end-point electrochemical detection system. In some embodiments, the dual-labeled signal probe may be used to assess the location and density of capture probes on an electrode.
Techniques for patient data management include obtaining medical history data of patients from a database, the medical history data including a history of one or more diagnosis events, one or more treatment events, and a clinical outcome event for each patient of the patients. For each patient, based on the medical history data, a computing system generates a patient pathway that includes a graph including nodes of one or more diagnosis events, the one or more treatment events, and the clinical outcome event. The computing system receives, via an interface, one or more criteria to select a subset of the patient pathways of the patients. The computing system selects, based on the one or more criteria, graphs representing the subset of the patient pathways. The computing system aggregates the subset of the patient pathways into a merged graph. The computing system displays the merged graph in the interface.
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
G16B 45/00 - TIC spécialement adaptées à la visualisation de données liées à la bio-informatique, p. ex. affichage de cartes ou de réseaux
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
84.
INSTRUMENT FOR PROCESSING CARTRIDGE FOR PERFORMING ASSAYS IN A CLOSED SAMPLE PREPARATION AND REACTION SYSTEM
In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 7/00 - Appareils de chauffage ou de refroidissementDispositifs d'isolation thermique
C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
The present disclosure relates to a method for isolating a biological target material from a liquid sample in a multiwell plate using magnetic particles, wherein high efficiency and low elution volumes are achieved by specific movements of the multiwell plate and a magnetic separation plate in relation to each other. Also disclosed is a pre-analytical system suitable for carrying out the method.
A machine learning model for traversing a decision tree, the machine learning model trained from a structured data set including a first set of key-value pairs and subject-specific criteria using the key-value pairs. The first set of key-value pairs is transformed into a second set of key-value pairs, which are projected to a subject-specific point within a multi-dimensional space. The decision tree includes decision and leaf nodes. Each leaf node is connected to a root node via a leaf-node-specific trajectory. Each decision node corresponds to a criterion using a value in the second set of key-value pairs. For each leaf node, a leaf-node-specific point within the multi-dimensional space is determined using the leaf-node-specific trajectory, and a similarity score is determined using the leaf-node-specific and subject-specific points. A subset of the leaf nodes is identified using the scores. State or protocol information for each leaf node in the subset is retrieved.
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
88.
METHODS FOR PERFORMING TEMPERATURE MULTIPLEXED PCR WITH INCREASED SENSITIVITY
The present invention describes methods for temperature multiplexed PCR for detection and quantitation of target nucleic acids with increased sensitivity. The methods are performed by contacting the sample with probes designed for temperature multiplexed PCR, measuring the fluorescence at multiple temperatures, subtracting signals to obtain calculated signals for each target of interest. Furthermore, the methods comprise obtaining a baseline of the first fluorescent signal, and adjusting the calculated signals using the obtained baseline of the first fluorescent signal to obtain a baseline shifted calculated signals.
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
In some embodiments, methods, systems, software and uses are provided for synchronizing medical images displays. An input identifying a region of interest in a first medical image is received. A second region of interest in a second medical image is determined based the first region. The first medical image and a first indication of the first region are displayed in a first viewport of a GUI. The second medical image and a second indication of the second region are displayed in a second viewport of the GUI. A display adjustment input is received to adjust the displaying of one of the first or second region of interest. Based on the display adjustment input and the correspondence information, an adjustment of the displaying of the first region of interest in the first viewport and an adjustment of the displaying of the second region of interest in the second viewport is implemented.
A61B 6/46 - Agencements pour l’interface avec l’opérateur ou avec le patient
G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
91.
INSTRUMENT FOR AUTOMATICALLY DISSECTING A BIOLOGICAL SPECIMEN ON A SLIDE
An instrument for automatically dissecting a biological specimen on a slide. The instrument comprises at least one imaging system. The imaging system comprises at least one camera configured for sequentially imaging at least one image of the slide at a plurality of slide positions. The imaging system comprises a relay lens system having a fixed focal length. The relay lens system is configured for relaying an impinging light beam from the slide to the camera. The instrument further comprises a movable xy-stage configured for setting the slide position. The instrument further comprises at least one processing unit configured for generating a full slide image by stitching the sequentially imaged images of the slide. Further, a method for automatically dissecting a biological specimen on a slide is proposed.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for genetic testing; chemical reagents, preparations and test kits for nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable software for use therewith sold as a unit
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; quantitative polymerase chain reaction (PCR) instrument for scientific use; scientific equipment, apparatus and instruments, namely, genome sequencers for scientific, pharmaceutical and medical research purpose; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, all for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Scientific research in the field of genome sequence analysis and reporting; medical research in the field of genome sequence analysis and reporting; dna screening for scientific research purposes; providing reagent sample testing services for others in the fields of science and scientific research; computer services, namely, cloud hosting provider services for storing, analyzing and sharing biological information; computer services, namely, hosting an interactive web site that allows users to store, analyze and share data in the field of life science; technical support services, namely, infrastructure management services for monitoring, administration and management of cloud computing it and application systems in the field of life science; consulting services in the field of cloud computing in the field of life science; providing temporary use of online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory apparatus, instruments and computer systems for use in analysis of biomolecules; installation and maintenance of computer software and database systems used in the field of analysis of biomolecules; consultancy, information and advisory services in the field of scientific analysis of biomolecules; product development, namely, developing equipment for use in preparing, detecting, analyzing and sequencing nucleic acids and other biological molecules, and automated laboratory equipment and systems, and computer systems for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data to the order and specification of others, all the foregoing in the fields of scientific and clinical research; clinical diagnostic services in preparing, amplifying, labeling, detecting, analyzing and sequencing nucleic acids and other biological molecules from human beings or animals for scientific and medical research purposes; design and development of medical diagnostic apparatus and instruments and computer systems for use in analysis of biomolecules; scientific consulting and research services and clinical laboratory testing services in the fields of amplification, detection, sequencing and analysis of nucleic acids and the preparation of nucleic acid libraries; nucleic acid sequencing services for scientific research purposes; scientific research, namely, computational analysis of nucleic acid sequences and development of computational technologies for the analysis of nucleic acid sequences
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for genetic testing; chemical reagents, preparations and test kits for nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable software for use therewith sold as a unit
95.
Display screen or portion thereof with graphical user interface for patient pathway reconstruction and aggregation
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; quantitative polymerase chain reaction (PCR) instrument for scientific use; scientific equipment, apparatus and instruments, namely, genome sequencers for scientific, pharmaceutical and medical research purpose; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, all for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Scientific research in the field of genome sequence analysis and reporting; medical research in the field of genome sequence analysis and reporting; dna screening for scientific research purposes; providing reagent sample testing services for others in the fields of science and scientific research; computer services, namely, cloud hosting provider services for storing, analyzing and sharing biological information; computer services, namely, hosting an interactive web site that allows users to store, analyze and share data in the field of life science; technical support services, namely, infrastructure management services for monitoring, administration and management of cloud computing it and application systems in the field of life science; consulting services in the field of cloud computing in the field of life science; providing temporary use of online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory apparatus, instruments and computer systems for use in analysis of biomolecules; installation and maintenance of computer software and database systems used in the field of analysis of biomolecules; consultancy, information and advisory services in the field of scientific analysis of biomolecules; product development, namely, developing equipment for use in preparing, detecting, analyzing and sequencing nucleic acids and other biological molecules, and automated laboratory equipment and systems, and computer systems for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data to the order and specification of others, all the foregoing in the fields of scientific and clinical research; clinical diagnostic services in preparing, amplifying, labeling, detecting, analyzing and sequencing nucleic acids and other biological molecules from human beings or animals for scientific and medical research purposes; design and development of medical diagnostic apparatus and instruments and computer systems for use in analysis of biomolecules; scientific consulting and research services and clinical laboratory testing services in the fields of amplification, detection, sequencing and analysis of nucleic acids and the preparation of nucleic acid libraries; nucleic acid sequencing services for scientific research purposes; scientific research, namely, computational analysis of nucleic acid sequences and development of computational technologies for the analysis of nucleic acid sequences
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
In vitro diagnostic agents, namely, reagents and control solutions for analysis of biological samples, all for medical diagnostic purposes; reagents for medical diagnostic use; medical diagnostic assays and reagents for testing of biological samples; reagent kits consisting of enzymes, oligonucleotides, nucleic acids, natural and modified nucleotides, buffers, labels, and substrates for medical diagnostic purposes; medical diagnostic test kits comprising reagents for genetic testing; chemical reagents, preparations and test kits for nucleic acid analysis for medical use; diagnostic kits consisting primarily of reagents for nucleic acid detection and analysis for medical diagnostic purposes; reagents for medical diagnostic use and diagnostic kits comprised of medical diagnostic reagents and assays for use in connection with dna sequencing and genetic analysis Clinical or medical diagnostic apparatus and instruments, namely, nucleic acid sequencers, imaging devices and analyzers; medical diagnostic apparatus and instruments for the amplification and analysis of nucleic acids and the preparation of nucleic acid libraries sold together in the form of kit; medical equipment, namely, devices for analyzing nucleic acids and for dna sequencing for the purpose of rendering medical treatment and diagnosis, and downloadable software for use therewith sold as a unit
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
In vitro diagnostic agents, namely, chemical control solutions for calibrating and monitoring the accuracy and function of instruments and test results, chemical additives, enzymes, reagents, organisms and proteins for use in science, research and industry; reagents for cell separation for scientific or research purposes; labeling reagents for scientific or research purposes; reagents for the processing, separation, isolation, enrichment, depletion, detection, screening, cultivation, analysis and counting of material, in particular of chemicals and biological material, all for scientific or research purposes; reagents featuring magnetic beads for scientific or research purposes; antibody reagents for scientific or research purposes; buffer solutions and reagents for use with laboratory apparatus, namely, separation apparatus and analysis apparatus, for scientific or research purposes; reagents for processing biological material, namely, tissue, bone marrow, cells, blood and components thereof for scientific or research purposes; reagents, enzymes, and nucleotides for nucleic acid sequencing for scientific or research purposes; diagnostic tests comprised of reagents and chemical test kits for determination of genetic information for scientific or research purposes; reagents for scientific or medical research use for analyzing cells, proteins, nucleic acids, sequencing dna, genotyping, gene expression profiling and high through-put screening; reagent kits composed primarily of oligonucleotides, enzymes and buffers for nucleic acid detection in the fields of scientific, pharmaceutical and medical research; nucleic acids, enzymes, buffers and chemical reagents for use in genotyping and gene expression test kits for detecting and analyzing nucleic acids for scientific or research purposes; assays and reagents for scientific or medical research use; diagnostic tests and test kits primarily composed of reagents and nucleotides for determination of genetic information for scientific or research purposes; reagents and chemical test kits for scientific and research use in connection with dna sequencing and genetic analysis Laboratory apparatus for sample preparation, amplification, mixing, hybridization, incubation, and washing, namely, arrays, beads, bead sets and flow cells; automated laboratory apparatus and systems, namely, sample loaders and bar code readers; quantitative polymerase chain reaction (PCR) instrument for scientific use; scientific equipment, apparatus and instruments, namely, genome sequencers for scientific, pharmaceutical and medical research purpose; downloadable computer software used for genotyping and gene expression microarrays for scientific, pharmaceutical and medical research purposes; downloadable computer software used in analyzing, managing and visualizing dna sequencing data; downloadable computer software used for preparation of nucleic acids libraries; computer hardware and downloadable computer software for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data, all for use in the fields of scientific, diagnostic and clinical research and for clinical diagnostic purposes Scientific research in the field of genome sequence analysis and reporting; medical research in the field of genome sequence analysis and reporting; dna screening for scientific research purposes; providing reagent sample testing services for others in the fields of science and scientific research; computer services, namely, cloud hosting provider services for storing, analyzing and sharing biological information; computer services, namely, hosting an interactive web site that allows users to store, analyze and share data in the field of life science; technical support services, namely, infrastructure management services for monitoring, administration and management of cloud computing it and application systems in the field of life science; consulting services in the field of cloud computing in the field of life science; providing temporary use of online non-downloadable software for the custom design and ordering of assays and reagents; design and development of laboratory apparatus, instruments and computer systems for use in analysis of biomolecules; installation and maintenance of computer software and database systems used in the field of analysis of biomolecules; consultancy, information and advisory services in the field of scientific analysis of biomolecules; product development, namely, developing equipment for use in preparing, detecting, analyzing and sequencing nucleic acids and other biological molecules, and automated laboratory equipment and systems, and computer systems for collecting, storing, analyzing and reporting biological information, and for sample tracking and managing projects, laboratory workflow and data to the order and specification of others, all the foregoing in the fields of scientific and clinical research; clinical diagnostic services in preparing, amplifying, labeling, detecting, analyzing and sequencing nucleic acids and other biological molecules from human beings or animals for scientific and medical research purposes; design and development of medical diagnostic apparatus and instruments and computer systems for use in analysis of biomolecules; scientific consulting and research services and clinical laboratory testing services in the fields of amplification, detection, sequencing and analysis of nucleic acids and the preparation of nucleic acid libraries; nucleic acid sequencing services for scientific research purposes; scientific research, namely, computational analysis of nucleic acid sequences and development of computational technologies for the analysis of nucleic acid sequences
99.
Compositions and Methods for Detecting Hepatitis Delta Virus by a Dual-Target Assay
Methods for the rapid detection of the presence or absence of Hepatitis Delta Virus (HDV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the HDV Ribozyme domain and the HDV Hepatitis Delta Antigen (HDAg) gene, along with kits are provided that are designed for the detection of HDV.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
