The invention discloses a complex of 3-hydroxybutyric acid and sodium 3-hydroxybutyrate and a preparation method thereof. The complex provided by the invention effectively solves the acid/salt load and gastrointestinal side effects associated with the existing products, has good taste comfort, and has a good ketogenic effect, and can be better used as a dietary or nutritional supplement.
The present invention provides methods, compositions (e.g., cycdrop or spongarion composition or food or supplement), and uses for alleviating and preventing age-associated lens degeneration in a subject, comprising administrating to the subject in need thereof an effective amount of ergothioneine, or a physiologically acceptable salt, acid, ester, polymer, analog or derivative thereof.
The present invention discloses a method and composition for improving hair follicle, scalp or hair health in a mammal and the related application thereof in preparing personal care product, cosmetic or medicine for improving hair follicle, scalp or hair health of a mammal. The method and composition of the invention inhibits the growth of a microorganism related to hair follicle, scalp or hair health, and/or eliminates inflammation, and/or inhibits folliculitis, scalp itching, dandruff, scalp oiliness, rashes, skin itching, scalp flaking, hair loss, tinea capitis, hypotrichosis, oligotrichosis, and lichen planopilaris.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61Q 5/00 - Préparations pour les soins des cheveux
A61Q 7/00 - Préparations pour modifier la pousse des cheveux ou des poils
A61Q 17/00 - Préparations protectricesPréparations employées en contact direct avec la peau pour protéger des influences extérieures, p. ex. des rayons du soleil, des rayons X ou d'autres rayons nuisibles, des matériaux corrosifs, des bactéries ou des piqûres d'insectes
Disclosed in the present invention are a physiologically acceptable salt of ergothioneine and a preparation method therefor. The method provided by the present invention can efficiently and stably produce the salt of ergothioneine. The salt of ergothioneine of the present invention solves the problems of peculiar odor, etc., of ergothioneine, and thus has wide application prospects in the field of dietary supplements, food products or cosmetics.
Disclosed are a method and composition for improving or maintaining the skin, hair follicle, scalp or hair health of a subject and related use thereof in preparing a personal care product and cosmetic product for improving or maintaining the skin, hair follicle, scalp or hair health of a subject. The method and composition of the present invention can inhibit the growth of microorganisms that cause skin problems, and/or promote the growth of microorganisms beneficial to the skin, and/or eliminate or mitigate skin problems, and/or inhibit the growth of hair follicle, scalp or hair health-related microorganisms, and/or eliminate or mitigate hair follicle, scalp or hair problems.
A61K 31/4172 - Acides imidazole-alkanecarboxyliques, p. ex. histidine
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A paraxanthine coffee and a preparation method therefor. The coffee comprises 0.1-10% (w/w) of paraxanthine, and less than 1% (w/w) of theobromine and/or theophylline. The preparation method for the coffee comprises: soaking and boiling coffee beans, weighing paraxanthine and preparing same into a suspension or a solution, roasting the coffee beans, spraying and applying the paraxanthine, and drying. The coffee has the effects of refreshing, improving sports performance and reducing weight.
A moisture-proof acetyl L-carnitine, comprising not less than 10% of acetyl L-carnitine by weight, or a hydrochloride thereof, or a mixture of both. A preparation method therefor comprises: mixing the following components according to a formula amount: acetyl L-carnitine, or a hydrochloride thereof or a mixture of both; one or more auxiliary materials selected from microcrystalline cellulose, compressible starch, lactose or mannitol; and one or more auxiliary materials selected from silicon dioxide, magnesium stearate, calcium hydrophosphate, calcium silicate and micronized silica gel; and granulating same to obtain a moisture-proof acetyl L-carnitine. The moisture-proof acetyl L-carnitine is formulated into a nutritional supplement, a food, a beverage or an animal feed.
A61K 31/221 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine avec des composés ayant un groupe amino, p. ex. acétylcholine, acétylcarnitine
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
8.
METHOD AND COMPOSITION FOR IMPROVING INTESTINAL MICROFLORA
The invention discloses a method and a composition for improving intestinal microflora, and the use thereof in preparing medicines, nutritional products, health care products, foods and beverages for regulating intestinal microflora. The tributyrin composition of the invention can significantly increase the level of a first intestinal microflora, and at the same time reduce the level of a second intestinal microflora in a mammal, thereby improving the intestinal health.
A moisture-proof anti-caking α-lipoic acid and a preparation method therefor. The moisture-proof anti-caking α-lipoic acid comprises not less than 20% by weight of α-lipoic acid, and may also comprise other auxiliary materials. By means of auxiliary material selection and treatment with a formulation method on the α-lipoic acid raw material, the problem of α-lipoic acid easily caking is solved, thereby improving the stability of the α-lipoic acid, meeting the requirement for high content, and facilitating transportation, storage and application scenarios.
The invention discloses a method for improving lipid metabolism in a subject, which comprises administering to the subject a composition comprising: an effective amount of beta-aminoisobutyric acid or a pharmaceutically acceptable salt, acid, ester or derivative thereof; as well as an effective amount of Grains of Paradise or Aframomum melegueta. The invention also discloses the composition and use thereof in preparing a nutritional supplement, food, beverage, animal feed or medicine for improving lipid metabolism in a subject. The method and composition of the invention may reduce body weight, reduce body fat mass, improve glucose tolerance and insulin sensitivity, decrease triglyceride and total cholesterol levels, or decrease leptin level; thereby reducing obesity epidemic and obesity-related metabolic disorders worldwide and improving health status.
A61K 36/906 - Zingiberaceae (famille du gingembre)
A61K 31/165 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
A61K 31/205 - Sels d'addition d'acides organiques avec des aminesSels d'ammonium quaternaire internes, p. ex. bétaïne, carnitine
A61K 35/60 - Poissons, p. ex. hippocampesŒufs de poisson
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
The present invention provides novel compositions and methods for preventing or alleviating fatigue, enhancing concentration, refreshing and awakening mind, improving energy, regulating or improving moods in a subject. The composition may comprise dihydroberberine (DHB), or a pharmaceutically acceptable salt, polymer, ester, acid, or an analog or derivative thereof.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
12.
ALITRETINOIN TO REDUCE OR INHIBIT ADVANCED GLYCATION END-PRODUCTS
Methods for reducing or inhibiting advanced glycation end products (AGEs) in a subject, comprising administration to the subject a composition comprising an effective amount of alitretinoin or a pharmaceutically acceptable salt, hydrate, ester, analog or derivative thereof. A composition comprising an effective amount of alitretinoin or a pharmaceutically acceptable salt, hydrate, ester, analog or derivative thereof, for reducing or inhibiting advanced glycation end products (AGEs) in a subject.
A method for preventing or delaying skin aging and maintaining or improving skin conditions. The method comprises: administering to a subject a composition comprising alitretinoin or a pharmaceutically acceptable salt, hydrate, ester, analog or derivative thereof. The method can effectively relieve skin photoaging, reduce fine lines and wrinkles on the skin, improve skin elasticity, skin firmness and skin glossiness, and whiten the skin and the like.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
antioxidants for use in the manufacture of food supplements; Antioxidants for use in the manufacture of food products; Antioxidants for use in the manufacture of food and beverages; Plant extracts to be used in the manufacture of food; Vitamins for use in the manufacture of food supplements; Plant extracts for the food industry; Tea extracts for the food industry. Dietary supplements for human beings; Food supplements for non-medical purposes; Dietary and nutritional preparations; Food supplements consisting of trace elements; Anti-oxidant food supplements; Food supplements for dietetic use; Dietetic foods adapted for medical purposes; Vitamin preparations in the nature of food supplements; Food supplements for sportsmen.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
antioxidants for use in the manufacture of food supplements; Antioxidants for use in the manufacture of food products; Chemical substances for use as food ingredients; Chemical additives for food; Chemical additives for use in the manufacture of food; Lecithin for the food industry; Phosphatides; Phosphatidylserine. Dietary supplements for human beings; Food supplements for non-medical purposes; Dietary and nutritional preparations; Fitness and endurance supplements; Food supplements for sportsmen; Food supplements for dietetic use.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
antioxidants for use in the manufacture of food supplements; Antioxidants for use in the manufacture of food products; Chemical substances for use as food ingredients; Chemical additives for food; Chemical additives for use in the manufacture of food; casein for the food industry; L- L-Tyrosine. Dietary supplements for human beings; Food supplements for non-medical purposes; Dietary and nutritional preparations; Fitness and endurance supplements; Food supplements for sportsmen; Food supplements for dietetic use.
17.
APPROACH TO REDUCE OR INHIBIT ADVANCED GLYCATION END-PRODUCTS
It provides novel methods for reducing or inhibiting advanced glycation end products (AGEs) in a subject, comprising administration to the subject a composition comprising an effective amount of ergothioneine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof; and an effective amount of another component or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof.It also provides a composition comprising ergothioneine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof; and another component or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, for reducing or inhibiting advanced glycation end products (AGEs) in a subject.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
The present invention relates to a method for suppressing deleterious effects of senescence in a mammal. The method includes administration to the mammal of a composition comprising therapeutically effective amount of ergothioneine, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. In some embodiments, the composition suppressing deleterious effects of senescence is by down-regulation of p21 and/or SAβG.
Moisture-proof L-α-glycerylphosphorylcholine and a preparation method therefor. For raw materials of L-α-glycerylphosphorylcholine, auxiliary materials are selected and treatment is carried out according to a formulation method, thereby solving the problem of strong hygroscopicity and deliquescent properties when L-α-glycerylphosphorylcholine is exposed to air, achieving excellent moisture-proof and anti-deliquescent effects, improving the stability of L-α-glycerylphosphorylcholine, and providing high applicability for a user.
The present invention provides a process for chemical synthesis of different optical forms of ergothioneine (e.g., L-form or D-form or any mixture thereof). Another aspect of the invention relates to a composition comprising a non-racemic mixture of L-ergothioneine and D-ergothioneine.
The present invention provides methods, compositions (e.g., eyedrop or spongarion composition), and uses for alleviating and preventing age-associated vitreous degeneration in a mammal, comprising administrating to the mammal in need thereof a therapeutically effective amount of L-ergothioneine, an analog or derivative thereof, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof, as an active ingredient. In particular, L-ergothioneine is capable of scavenging chronic reactive oxygen species directly and radically to mitigate and prevent HA depolymerization and HA decreasing-viscosity in the mammal's vitreous body; and/or improving vitreous liquefaction in the mammal.
Disclosed in the present invention are a method and composition for regulating or increasing intestinal microbiota, and the use thereof in the preparation of drugs, nutritional products, healthcare products, food products and beverages for regulating intestinal flora. The dehydrozingerone-containing composition of the present invention can significantly regulate or increase the level of the intestinal flora in a subject, and increase dopamine in the brain by means of regulating or increasing the level of the intestinal flora in a subject, thus enhancing the athletic performance.
A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
A61K 31/7034 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine
C07C 49/255 - Composés non saturés comportant des groupes cétone liés à des atomes de carbone acycliques contenant des groupes éther, des groupes , des groupes ou des groupes
A01N 65/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux contenant du matériel provenant d'algues, de lichens, de bryophytes, de champignons multicellulaires ou de plantes, ou leurs extraits
24.
COMPOSITIONS AND METHODS FOR PROMOTING GLYCOGEN SYNTHASE ACTIVITY AND AUGMENTING GLYCOGEN STORAGE CAPABILITY
The present invention provides compositions and methods for promoting glycogen synthase activity and augmenting glycogen storage capability in muscle tissue and/or liver tissue in a mammal, relating to administration to the mammal of an effective amount of β-aminoisobutyric acid (BAIBA), an analog or derivative thereof, or a pharmaceutically acceptable salt, ester, acid, polymer, analog or derivative thereof.
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
25.
METHOD AND COMPOSITION FOR PROTECTING OR IMPROVING OVARIAN FUNCTION IN MAMMALS
A method and composition for protecting or improving ovarian function in mammals, and the related use of the composition in the preparation of a food, beverage, nutritional supplement and animal feed for the improvement of ovarian function in mammals. The method and composition can increase the number of follicles, improve the quality of follicles, improve the ovarian function, and delay aging.
A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
A61P 15/08 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les troubles gonadiques ou pour augmenter la fertilité, p. ex. inducteurs d'ovulation ou de spermatogénèse
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
Disclosed in the present invention are a crystal form of ergothioneine and a preparation method therefor. The method provided in the present invention can efficiently and stably prepare an anhydrous crystal form of ergothioneine; and the crystal form of ergothioneine of the present invention has a high purity, a high mass fraction, a low moisture content and a high crystallization yield, and thus has wide application prospects in the fields of dietary supplements, food or cosmetics.
C07D 233/66 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle
C07D 233/54 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
27.
METHOD AND COMPOSITION TO REDUCE OR INHIBIT ADVANCED GLYCATION END-PRODUCTS
Novel methods for reducing or inhibiting advanced glycation end products (AGEs) in a subject, comprising administration to the subject a composition comprising an effective amount of tetrahydrocurcumin or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof; and an effective amount of ergothioneine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. A composition comprising an effective amount of tetrahydrocurcumin or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof; and an effective amount of ergothioneine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, for reducing or inhibiting advanced glycation end products (AGEs) in a subject.
The methods for improving a benefit of an exercise experienced by a subject,comprising administration to the subject a composition comprising an effective amount of Grains of Paradise,analog or derivative thereof.
The invention provides a topical composition for preventing or treating skin aging, comprising at least one compound selected from the group consisting of ergothioneine, an analog or derivative thereof, or a dermatologically acceptable salt thereof. This topical composition improves skin's radiance, luminosity or texture, and rarely produces skin irritation. In another aspect, this invention provides a method for preventing or treating photoaging in a subject, comprising topical application of the composition of the invention.
A61K 31/4172 - Acides imidazole-alkanecarboxyliques, p. ex. histidine
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A skin care composition, containing a first active component and a second auxiliary component. The first active component is selected from one or more of tetrahydrocurcumin, ergothioneine, phloretin, arbutin, resveratrol, vitamin C, dipotassium glycyrrhizinate, a ceramide, an Aloe vera polysaccharide, an Opuntia dilenil polysaccharide, an Astragali radix polysaccharide, a Dendrobii caulis polysaccharide, a Rhei radix et rhizoma polysaccharide, fucoidan, small-molecule hyaluronic acid, pearl powder, collagen, tea tree essential oil, thearubigins, salicylic acid, retinol, glycoxyl and carnosine; and the second auxiliary component is selected from one or more of tetrahydropiperine, laurocapram, PEG-75 shea butter glycerides, hydrogenated castor oil, glycerol, lauric acid, sucrose laurate, butanediol, a polysorbate, hydroxyethyl cellulose, 1,2-pentanediol and ethoxydiglycol. The skin care composition can be used for whitening, anti-inflammation, anti-sugar, moisturizing, skin tightening, anti-bacteria and/or anti-aging.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
A61Q 19/08 - Préparations contre le vieillissement
Disclosed in the present invention is a solid beverage composition, containing, by weight, 10-60% of carbohydrate, 5-20% of glycerol, 10-80% of electrolytes, and 0-8% of vitamins. The osmotic pressure molar concentration of the brewed solid beverage composition of the present invention is 280-320 mosmol/kg, realizing ideal moisture retention and loss prevention and rapid electrolyte replenishment functions.
Disclosed in the present invention is an arachidonyl ethanolamide composition. The arachidonyl ethanolamide composition comprises, by weight, 30-75 parts of arachidonyl ethanolamide, 5-15 parts of linoleyl ethanolamide, and 2-18 parts of oleoyl ethanolamide. The arachidonyl ethanolamide composition of the present invention can achieve a good anti-depressant effect.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Chemical additives for use in the manufacture of food supplements; Phosphatides; Antioxidants for use in the manufacture of food supplements; Phosphatidylserine
34.
COMBINATION OF DIHYDROBERBERINE AND ERGOTHIONEINE TO REDUCE OR INHIBIT ADVANCED GLYCATION END-PRODUCTS
It provides methods for reducing or inhibiting advanced glycation end products (AGEs) in a subject, comprising administration to the subject a composition comprising an effective amount of Dihydroberberine or its pharmaceutically acceptable salt, acid, ester, analog or derivative thereof; and an effective amount of Ergothioneine or its pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. It also provides a composition comprising an effective amount of Dihydroberberine or its pharmaceutically acceptable salt, acid, ester, analog or derivative thereof; and an effective amount of Ergothioneine or its pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, for reducing or inhibiting advanced glycation end products (AGEs) in a subject.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
The disclosure provides L-ergothioneine, novel forms of L-ergothioneine, and uses thereof, particularly for immune support and nutrient supplementation. In particular, the disclosure provides a method of improving a mammal's immune response to a microbial infection; an orally administered unit dosage form; and a method of inducing the production of reactive oxygen species in polymorphonuclear leukocytes in a mammal.
Provided herein are novel methods for promoting recruitment and activation of brown adipose tissues (BAT) or arousing browning of white adipose tissues (WAT) in a mammal, comprising administration to the mammal a composition comprising an effective amount of dihydroberberine or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof. It also provides a composition comprising an effective amount of dihydroberberine or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof, for promoting recruitment and activation of brown adipose tissues (BAT) or arousing browning of white adipose tissues (WAT) in a mammal.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
A61P 5/50 - Médicaments pour le traitement des troubles du système endocrinien des hormones pancréatiques pour augmenter ou potentialiser l'activité de l'insuline
A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
It provides methods for increasing a benefit of losing weight of a mammal treated with every-other-day fasting (EODF), comprising administrating to the mammal an effective amount of Dihydroberberine, an analog or derivative thereof, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
A61P 5/50 - Médicaments pour le traitement des troubles du système endocrinien des hormones pancréatiques pour augmenter ou potentialiser l'activité de l'insuline
30 - Aliments de base, thé, café, pâtisseries et confiseries
Produits et services
Extracts used as food flavoring; Flavorings for beverages, other than essential oils; Flavourings, other than essential oils, for cakes; Food flavourings, other than essential oils; Natural sweetener; Stevia extracts for use as a food flavoring
40.
COMPOSITIONS AND METHODS FOR IMPROVING EXERCISE PERFORMANCE OR PREVENTING OR RELIEVING FATIGUE
The present invention provides a method for improving exercise performance or preventing or relieving fatigue in mammal, including administration to the mammal a composition including: (i) an effective amount of BAIBA, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof; and (ii) an effective amount of creatine. The present invention also provides a composition, including (i) an effective amount of BAIBA, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof; and (ii) an effective amount of creatine, for improving exercise performance or preventing or relieving fatigue in a mammal. The methods and compositions of the invention can be used for enhancing muscle strength, increasing muscle content, improving muscle endurance; preventing body fatigue after exercise, accelerating recovery after exercise.
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
A61P 3/02 - Nutriments, p. ex. vitamines, minéraux
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Antioxidants for use in the manufacture of food supplements; Antioxidants for use in the manufacture of pharmaceuticals; Plant extracts, other than essential oils, for the food industry; Plant extracts, other than essential oils, for use in the manufacture of pharmaceuticals
42.
Method and Composition for Mimicking Caloric Restriction by Administration of Ergothioneine
Among others, the present invention provides methods and compositions for mimicking one or more biological benefits of caloric restriction in a mammal, including administering to the mammal an effective amount of Ergothioneine, an analog or derivative thereof, or a pharmaceutically acceptable salt, ester, polymer, acid, analog or derivative thereof.
The uses of a composition containing N-arachidonoyl ethanolamine anandamide or a derivative thereof for in preparation ofpreparing nutritional supplements and health-care products, foods and beverages used for regulating the intestinal flora. The composition can remarkably improve the level of a first intestinal microflora microbiota in a subjects and also reduce the level of a second intestinal microflora in the subjects, thereby improving the intestinal health. The first intestinal microflora microbiota is selected from one or more of the following groups: Roseburias, Bacteroides and Prevotellas, and the second intestinal microflora is Salmonella or Escherichia coli.
Disclosed in the present invention are a complex of 3-hydroxy-3-methylbutyric acid and a salt thereof, and a preparation method therefor. The complex provided in the present invention effectively solves the problems of low solubility, poor stability, acid/salt load, excessive intake of calcium and gastrointestinal side effects caused by existing products, has a good taste comfort, has an improved flavor, has better effects in terms of increasing muscle weight, improving muscle performance, joint functions, body components or enhancing health, etc., and can be better used as a dietary or nutritional supplement.
C07C 59/01 - Composés saturés ne comportant qu'un groupe carboxyle et contenant des groupes hydroxyle ou O-métal
C07C 51/41 - Préparation de sels d'acides carboxyliques par conversion de ces acides ou de leurs sels en sels ayant la même partie acide carboxylique
C07C 227/18 - Préparation de composés contenant des groupes amino et carboxyle liés au même squelette carboné à partir de composés contenant déjà des groupes amino et carboxyle ou leurs dérivés par des réactions impliquant des groupes amino ou carboxyle, p. ex. hydrolyse d'esters ou d'amides, par formation d'halogénures, de sels ou d'esters
A61K 31/19 - Acides carboxyliques, p. ex. acide valproïque
A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
A method for regulating emotions in a mammal, comprising: administering a composition to a mammal, wherein the composition contains an effective amount of hydrolyzed vegetable protein, the hydrolyzed vegetable protein is hydrolyzed soy protein, and the emotion regulation comprises relieving anxiety, pressure, or depression. The present invention further relates to a composition, containing an effective amount of hydrolyzed vegetable protein and used for regulating emotions in a mammal. In addition, the present invention further relates to a use of the composition in preparation of food, drinks, nutritional supplements, and animal feed for regulating emotions in a mammal.
Provided are a method and composition for improving or maintaining the skin health of mammals and related use thereof in preparing personal care products, cosmetics or drugs for improving or maintaining the skin health of mammals. The method or composition can inhibit the growth of microorganisms that cause skin problems, and/or promote the growth of microorganisms beneficial to the skin, and/or eliminate or mitigate skin problems.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
Among others, the present invention provides low-lead and low-arsenic beta-hydroxybutyrate (BHB) salts, comprising lead ranging from 10 to 50 parts per billion (ppb) and arsenic ranging from 10 to 150 ppb. The present invention also provides methods for preparing low-lead and low-arsenic beta-hydroxybutyrate (BHB) salts, which may include (a) synthesizing, (b) adsorbing (e.g., by adsorbent and solvent), (c) concentrating under reduced pressure, and (d) spray drying.
A sustained-release formulation of β-hydroxybutyrate or salts thereof, comprising the following components in percentage by weight: 40%-50% of β-hydroxybutyrate or salts thereof, 40%-60% of a sustained-release framework matrix material, and 1%-3% of an excipient. The sustained-release formulation has excellent dispersion properties in water, can realize the sustained release of β-hydroxybutyrate or the salts thereof at the same time, and can maintain a stable and effective plasma concentration in vivo for a long time, which has very important significance for practical application of β-hydroxybutyrate or the salts thereof.
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A61K 31/19 - Acides carboxyliques, p. ex. acide valproïque
The present invention provides methods and compounds for enhancing mitochondrial biogenesis in a mammal or for activating PGC-1α in a mammal, comprising administrating to the mammal in need thereof a therapeutically effective amount of L-Ergothioneine, an analog or derivative thereof, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof (e.g., as an active ingredient). Such administration of L-Ergothioneine is also capable of alleviating mitochondrial dysfunction and boosting cellular function by enhancing mitochondrial biogenesis, and/or promoting health and longevity by improving mitochondrial biogenesis.
A plant-derived composition, comprising, by weight, 30%-50% of a first plant component, 37%-57% of a second plant component, and 5%-20% of a third plant component. The first plant component is selected from one or more of quercetin, a green tea extract, a broccoli bud extract, an onion extract, an apple extract, a tomato extract, a broccoli extract, a Camu Camu fruit extract, an Acerola cherry extract, a blueberry extract, a Prunus avium extract, a raspberry extract, a spinach extract, an aronia melanocarpa extract, a kale extract, a blackberry extract and a cowberry extract; the second plant component is selected from one or more of an olive extract, a clove extract and resveratrol; and the third plant component is selected from one or more of a Rosmarinus officinalis extract and a grape seed extract. The plant-derived composition is used for preparing foods, beverages, nutraceuticals, dietary supplements and cosmetics.
Disclosed herein is a method for improving muscle performance of a mammal, which comprises administering a composition to the mammal, the composition comprising an effective amount of a plant protein hydrolysate. Also disclosed is a composition comprising an effective amount of a plant protein hydrolysate and used for improving muscle performance of a mammal. The method and the composition of the present invention can ameliorate motion capability reduction caused by muscle injury, relieve muscular soreness, relieve or resist muscle injury, or reduce inflammatory response.
The present invention provides a preparation method for a light-colored water-soluble vegetable protein. The method comprises: adding protease and glucose oxidase into a vegetable protein solution for enzymolysis to obtain a water-soluble vegetable protein. The method effectively reduces browning reactions in the enzymolysis process, not only diminishing pigmentation but also ensuring that the yield of peptide products remains undiminished.
Among others, the present invention provides beta-hydroxybutyrate (BHB) salt granules, comprising BHB salts and fillers. The present invention also provides methods for producing BHB salt granules, wherein the BHB salt granules are prepared by granulation process. The production methods may include (a) wet granulation; (b) extrusion; (c) spheronization; and (d) drying.
Provided herein are novel methods for anti-aging, especially ameliorating or preventing vascular endothelial damage induced by progerinin a mammal, comprising administration to the mammal a composition comprising an effective amount of ergothioneine (EGT) or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. Also provided is a composition comprising an effective amount of ergothioneine (EGT) or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, for anti-aging, especially ameliorating or preventing vascular endothelial damage induced by progerinin a mammal.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
(1) Dihydroberberine
(2) Antioxidants for use in the manufacture of food supplements; chemical additives for use in the manufacture of food; chemical additives for use in the manufacture of pharmaceuticals
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Glycerol; Chemical additives for use in the manufacture of food; Chemical additives; Chemical preparations for use in the food industry; Chemical compositions and materials for use in the manufacture of cosmetics; Esters of polyols for use as ingredients in foodstuffs; Chemical substances for use as food ingredients.
58.
Method for Preparing Moisture-Proof Amino Acid Materials
The present invention provides novel methods for preparing a moisture-proof amino acid material. The present invention also provides novel compositions or nutritional supplements comprising the moisture-proof amino acid materials prepared by the methods of this invention.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Fruit extracts for use in the manufacture of food; Plant extracts, other than essential oils, for use in the manufacture of food; Tea extracts for the food industry; Tea extracts for use in the manufacture of pharmaceuticals
60.
Use of L-ergothioneine to ameliorate and prevent age-related vitreous degeneration
The present invention provides methods, compositions (e.g., eyedrop or spongarion composition), and uses for alleviating and preventing age-associated vitreous degeneration in a mammal, comprising administrating to the mammal in need thereof a therapeutically effective amount of L-ergothioneine, an analog or derivative thereof, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof, as an active ingredient. In particular, L-ergothioneine is capable of scavenging chronic reactive oxygen species directly and radically to mitigate and prevent HA depolymerization and HA decreasing-viscosity in the mammal's vitreous body; and/or improving vitreous liquefaction in the mammal.
The present invention provides methods and compositions for alleviating and preventing age-associated visual degeneration in a mammal, comprising administrating to the mammal in need thereof an effective amount of L-Ergothioneine, an analog or derivative thereof, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof, as an active ingredient. In particular, the administration of L-Ergothioneine is capable of controlling subretinal choroidal neovascularization (CNV) level in the mammal's retina; activating Nrf2-mediated antioxidant genes to scavenge chronic reactive oxygen species and decrease vascular endothelial growth factor (VEGF) level in the mammal's retinal pigment epithelium (RPE); activating Nrf2-mediated antioxidant genes by lowering the damage induced by oxidative stress (OS) in the mammal's RPE; and/or inhibiting oxidation-induced epithelial-to-mesenchymal transition (EMT) to prevent epithelial fibrosis in RPE in mammals' RPE.
The present invention provides methods for providing a mammal with a benefit associated with every-other-day fasting (EODF), or increasing a benefit of losing weight of a mammal treated with every-other-day fasting (EODF), comprising administrating to the mammal a therapeutically effective amount of β-aminoisobutyric acid (BAIBA), an analog or derivative thereof, or a pharmaceutically acceptable salt, acid, ester, polymer, analog or derivative thereof. The benefit may include reducing a body fat percentage of the mammal, reducing the weight of the mammal, lowering a blood glucose of the mammal, decreasing a blood triglyceride level of the mammal, decreasing a blood total cholesterol level of the mammal, decreasing a blood low-density lipoprotein level of the mammal, decreasing a blood very low-density lipoprotein level of the mammal, improving leptin resistance of the mammal, and/or improving insulin resistance of the mammal.
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
A complex, comprising 3-hydroxybutyric acid and sodium 3-hydroxybutyrate. The 3-hydroxybutyric acid and sodium 3-hydroxybutyrate are in a ratio of 1: 10 to 10: 1. The preparation method therefor comprises: (1) obtaining substance A by means of one of the following methods: mixing 3-hydroxybutyric acid and sodium 3-hydroxybutyrate; or adding 3-hydroxybutyric acid to an aqueous solution of alkaline Na compound, stirring the mixture, and carrying out distillation to remove the water until the product is nearly dry; or heating the alkyl 3-hydroxybutyrate and water in the presence of a catalyst for a reaction, carrying out cooling and filtering, adding an aqueous solution of alkaline Na compound to the filtrate, and carrying out distillation under reduced pressure to remove the water until the product is nearly dry; (2) adding one or more solvents selected from the following materials to the substance A obtained in step (1): water, THF, DMF, DMSO, DMAC, alcohols, halogenated hydrocarbons, ketones and esters, stirring and cooling the mixture to precipitate out a solid; and (3) filtering out the solid and drying same to obtain the complex. The use of the complex in the preparation of a ketogenic substance for raising or maintaining the blood ketone level in a subject.
A composite, comprising: 3-hydroxybutyric acid; and one or more of potassium 3-hydroxybutyrate, or calcium 3-hydroxybutyrate, or magnesium 3-hydroxybutyrate. A composite, wherein the anion comprises 3-hydroxyvaleric acid, and the cation comprises sodium and hydrogen. The composite has suitable hygroscopicity and stability. At a suitable dosage, the composite has a relatively good ketogenic effect.
A composition of a sunflower seed protein or an isolated protein, protein hydrolysate or concentrated protein thereof, and the use thereof in the preparation of a drug, nutritional product, health-care product, food product, beverage and animal feed for regulating intestinal flora. The composition of the sunflower seed protein or the isolated protein, protein hydrolysate or concentrated protein thereof can significantly increase the level of first intestinal microflora in a subject, and simultaneously reduce the level of second intestinal microflora in the subject so as to improve the intestinal health, thereby improving overall health. The first intestinal microflora is Lactobacillus acidophilus or Bifidobacterium, and the second intestinal microflora is Escherichia coli or Staphylococcus aureus.
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
A23K 10/30 - Produits alimentaires pour animaux à base de matières d’origine végétale, p. ex. de racines, de graines ou de foinProduits alimentaires pour animaux à base de matières d’origine fongique, p. ex. de champignons
66.
BETA-HYDROXYBUTYRATE WITH PURE BIOBASED CARBON CONTENT AND METHODS FOR PRODUCING THE SAME
Among others, the present invention provides for beta-hydroxybutyrate (e.g., R—BHB) acids and/or salts with pure biobased carbon content (e.g., 100% as measured by Carbon-14 analysis). The present invention also provides methods for preparing beta-hydroxybutyrate (e.g., R—BHB) acid and salt with pure biobased carbon content, comprising chemical synthesis and/or biosynthesis process. For instance, the method may include biological fermentation, and/or bioenzymatic process.
A composition of a pumpkin seed protein or an isolated protein, protein hydrolysate or concentrated protein thereof, and the use thereof in the preparation of a drug, nutritional product, health-care product, food product, beverage and animal feed for regulating intestinal flora. The intestinal flora is selected from one or more of the following: Lactobacillus acidophilus, Streptococcus thermophilus, Bifidobacterium longum and Bifidobacterium lactis.
A23K 10/18 - Ajout de micro-organismes ou de leurs produits d’extraction, p. ex. de protéines provenant d’organismes unicellulaires, à des compositions de produits alimentaires de micro-organismes vivants
Among others, the present invention provides methods for ameliorating and preventing age-associated muscle degeneration in a mammal, comprising administrating to the mammal in need thereof a therapeutically effective amount of L-Ergothioneine, an analog or derivative thereof, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, as an active ingredient. In particular, the administration of L-Ergothioneine is capable of attenuating the loss of muscle mass and/or strength in the mammal, and is capable of improving adenosine triphosphate (ATP) production, improving the P/O ratio (ATP produced per O2 consumed), and/or scavenging and blocking chronic reactive oxygen species (ROS) in the mammal.
Disclosed are a method and composition for improving the health of hair follicles, scalp or hair of mammals and related use thereof in the preparation of personal care products, cosmetics or medicaments for improving the health of hair follicles, scalp or hair of mammals. The method and composition of the present invention can inhibit the growth of microorganisms related to the health of hair follicles, scalp or hair and/or eliminate inflammation, and/or inhibit folliculitis, itching in head, dandruff, hair oil, rash, skin itching, scalp exfoliation, hair loss, tinea capitis, hypotrichosis, oligotrichosis, and lichen planopilaris.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61Q 7/00 - Préparations pour modifier la pousse des cheveux ou des poils
A61Q 5/00 - Préparations pour les soins des cheveux
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
Disclosed herein are a dihydroberberine composition and use thereof in the preparation of medicaments, nutritional products, health-care products, foods and beverages for regulating the intestinal flora. The dihydroberberine composition of the present invention can significantly increase the level of a first intestinal microbiota in a subject, while reducing the level of a second intestinal microbiota in the subject, thereby improving the intestinal health.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
Disclosed is a method for improving a lipid metabolism function of a subject, comprising administering to the subject a composition comprising an effective amount of β-aminoisobutyric acid or a pharmaceutically acceptable salt, an acid, an ester or a derivative thereof, and an effective amount of grains of paradise or Aframomum melegueta. Further disclosed are the composition and the use thereof in the preparation of nutritional supplements, foods, beverages, animal feed, or drugs for improving the lipid metabolism function of the subject. The method and the composition of the present invention can reduce weight, reduce body fat mass, improve sugar tolerance and insulin sensitivity, lower the levels of triglyceride and total cholesterol, and reduce the level of leptin, thereby reducing the global obesity epidemic and metabolic disorders related to obesity, and improving the health condition.
A61P 3/08 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose
A61P 5/50 - Médicaments pour le traitement des troubles du système endocrinien des hormones pancréatiques pour augmenter ou potentialiser l'activité de l'insuline
A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
A23K 10/30 - Produits alimentaires pour animaux à base de matières d’origine végétale, p. ex. de racines, de graines ou de foinProduits alimentaires pour animaux à base de matières d’origine fongique, p. ex. de champignons
The present invention provides compositions and methods for promoting glycogen synthase activity and augmenting glycogen storage capability in muscle tissue and/or liver tissue in a mammal, relating to administration to the mammal of an effective amount of β-aminoisobutyric acid (BAIBA), an analog or derivative thereof, or a pharmaceutically acceptable salt, ester, acid, polymer, analog or derivative thereof.
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
73.
METHOD AND COMPOSITION FOR IMPROVING INTESTINAL MICROBIOTA
Disclosed are a method and a composition for improving intestinal microbiota and use thereof for preparing drugs, nutritional products, health-care products, foods, and beverages for regulating intestinal flora. The tributyrin composition of the present invention can significantly increase the level of a first intestinal microbiota in mammals while reducing the level of a second intestinal microbiota in mammals to improve intestinal health.
Coated beta-hydroxybutyrate (BHB) free acid crystal pellets/granules are provided, which comprise BHB free acid crystal, fillers, and coating material. Methods for producing coated BHB free acid crystal pellets/granules are provided, which may include (a) wet granulation, (b) extrusion, (c) spheronization, and (d) coating, such as coating material spray embedding through Wurster bottom spray coating device.
Among others, the present invention provides a liposome comprising an active ingredient and one membrane or one inner membrane and one outer membrane. Each membrane comprises a plurality of lipid molecules, and the active ingredient is entrapped inside the interior space defined by the membrane or the inner membrane, or embodied in the membrane or membranes and form a part of the membrane(s).
A61K 31/19 - Acides carboxyliques, p. ex. acide valproïque
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Amino acids for laboratory or research use; Antioxidants and proteins used in the manufacture of cosmetics, beverages, food products and food supplements; Casein for the food industry; Protein in raw material form for scientific and medical research; Proteins for use in the manufacture of food supplements
77.
USE OF ERGOTHIONEINE TO SUPPRESS DELETERIOUS EFFECTS OF SENESCENCE
The present invention relates to a method for suppressing deleterious effects of senescence in a mammal. The method includes administration to the mammal of a composition comprising therapeutically effective amount of ergothioneine, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. In some embodiments, the composition suppressing deleterious effects of senescence is by down-regulation of p21 and/or SAβG.
Compositions of β-aminoisobutyric acid (BAIBA), and methods of using the same to achieve a physiological objective, are provided. Compositions of BAIBA having enantiomeric purity, in which a selected proportion of the BAIBA is L-β-aminoisobutyric acid (L-BAIBA) and/or a selected proportion of the BAIBA is D-β-aminoisobutyric acid (D-BAIBA), are also provided.
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
The present invention provides a process for chemical synthesis of different optical forms of ergothioneine (e.g., L-form or D-form or any mixture thereof). Another aspect of the invention relates to a composition comprising a non-racemic mixture of L-ergothioneine and D-ergothioneine.
Among others, this invention provides a soft capsule comprising β-hydroxybutyric acid (BHB) or a pharmaceutically acceptable salt, ester, liposome, or mixture thereof as active ingredient, as well as method of making such soft capsule.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Active chemical ingredients for use in the manufacture of pharmaceuticals for treating joint disease; Antioxidants and proteins used in the manufacture of cosmetics, beverages, food products and food supplements; Chemical additives for use in the manufacture of food
82.
USE OF ERGOTHIONEINE FOR EXTENDING LIFESPAN OR IMPROVING HEALTHSPAN
The present invention provides methods for extending lifespan or improving healthspan in a mammal, which includes administration to the mammal of a composition containing an effective amount of ergothioneine, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof.
Among others, the invention provides a topical composition for preventing or treating skin aging, comprising at least one compound selected from the group consisting of ergothioneine, an analog or derivative thereof, or a dermatologically acceptable salt thereof. This topical composition improves skin's radiance, luminosity or texture, and rarely produces skin irritation. In another aspect, this invention provides a method for preventing or treating photoaging in a subject, comprising topical application of the composition of the invention.
Among others, the present disclosure provides methods for extending lifespan or improving healthspan in a mammal, which includes administration to the mammal of a composition containing an effective amount of ergothioneine, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof.
Provided are methods for improving exercise performance and endurance of a mammal, comprising administering to the mammal in need thereof a composition comprising dihydroberberine (DHB), or an analog or derivative thereof, and a physiologically acceptable carrier. DHB in the composition can serve as an antioxidant to defend red blood cells against oxidative stress damage, by scavenging reactive oxygen species generated during to increase the deformability and the survival of red blood cells.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Antioxidants for use in the manufacture of cosmetics, beverages, food products and food supplements; Carbohydrates used as an ingredient in the manufacture of nutraceuticals; Enzymes for use in the manufacture of nutraceuticals; Fatty acids for use in dietary supplements field; Glycerine for use in the manufacture of food, pharmaceuticals, cosmetics; Lipids used in the manufacture of cosmetics, beverages, food products and food supplements; Microbes for use in the manufacture of probiotic supplements and food for humans; Probiotic bacteria for use in the manufacture of food supplements, food, cosmetics; Proteins for use in the manufacture of cosmetics, beverages, food products and food supplements; Vitamins for use in the manufacture of food supplements
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
Produits et services
Cosmetic ingredient complex composed of antioxidants and humectants sold as an integral component of non-medicated skincare preparations; Cosmetic preparations for skin renewal; Cosmetic sunscreen preparations; Cosmetics and cosmetic preparations; Facial creams; Non-medicated herbal body care products, namely, sunscreen cream; Non-medicated preparations all for the care of skin, hair and scalp; Skin conditioners; Suntanning preparations; face, body, hand moisturizers
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Calcium montmorillonite clay for therapeutic purposes used to enhance the production of enzymes in living beings or as a mineral supplement; Dietary beverage supplements for human consumption in liquid and dry mix form for therapeutic purposes; Dietary food supplements; Dietary supplement for eliminating toxins from the intestinal tract; Lecithin dietary supplements; Liquid nutritional supplement; Natural herbal supplements; Nutritional supplement in the nature of a nutrient-dense, protein-based drink mix; Probiotic supplements; Soy protein dietary supplements
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Biotechnology research; Conducting early evaluations in the field of new pharmaceuticals; Development of new technology for others in the field of genomics, biotechnology; Pharmaceutical product evaluation; Scientific consulting and research services relating to foods and dietary supplements; Scientific research and development; Scientific study and research in the field(s) of medicine, the prevention, treatment and management of illness, health care delivery; Technical consultancy in relation to research services relating to foods and dietary supplements; Technical research in the field of pharmaceutical studies; Testing, inspection or research of pharmaceuticals, cosmetics or foodstuff
Arranging and conducting of fairs and exhibitions for business and advertising purposes; Online retail services through direct solicitation by salespersons directed to end-users featuring dietary supplement field; Organizing business networking events in the field of dietary supplements ingredients industry; Promoting awareness of the benefits of making health, wellness and nutritional changes in daily living to enable businesses to increase productivity and lower health care costs; Providing information about commercial business and commercial information via the global computer network; Provision of an online marketplace for buyers and sellers of goods and services; Retail on-line ordering services featuring dietary supplement ingredients also accessible by telephone, facsimile and mail order; Retail services through direct solicitation by salespersons directed to end-users featuring dietary supplement industry; Web-based catalog services featuring dietary supplement ingredients; Wholesale services through direct solicitation by salespersons directed to end-users featuring dietary supplement field
94.
METHOD FOR PREPARINGMOISTURE‐PROOF AMINO ACID MATERIALS
The present invention provides novel methods for preparing a moisture‐proof amino acid material. The present invention also provides novelcompositionsor nutritional supplementscomprising the moisture‐proof amino acid materials prepared by the methods of this invention.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Development and establishment of testing specifications and procedures for the dietary supplement industry; Development of new technology for others in the field of biotechnology; Product development in the field of dietary supplement; Product research and development; Research and development of technology in the field of dietary supplement; Research on food; Testing, analysis and evaluation of collagen, vegan protein such as pea protein, mung bean protein and rice protein to determine conformity with established accreditation standards; Testing, analysis, and evaluation of the goods of others to assure compliance with industry standards
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Design and testing of new products, namely, new dietary supplement, for others; Product development; Testing, inspection or research of pharmaceuticals, cosmetics or foodstuff
97.
USE OF DIHYDROBERBERINE OR ITS DERIVATIVES FOR ANTI-GLYCATION
The present invention provides novel methods for anti-glycation, especially mitigating or preventing skin aging in a mammal, the method includes administration to the mammal of a composition including an effective amount of dihydroberberine (DHB) or its analog or its derivatives. The present invention also provides a composition including an effective amount of dihydroberberine (DHB) or its analog or its derivatives, for mitigating or preventing “Maillard reaction” in a mammal by controlling blood glucose, scavenging chronic ROS, reducing a level of MDA and expression of MMP-1. In addition, the present invention provides method for preparing any compositions disclosed herein.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61P 3/08 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose
98.
USE OF DIHYDROBERBERINE OR ITS DERIVATIVES FOR ANTI-AGING
The present invention provides novel methods for anti-aging, especially ameliorating or preventing skin aging, cellular senescence, or photoaging through inhibiting progerin in a mammal. The method includes administration to the mammal a composition including an effective amount of dihydroberberine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. The present invention also provides a composition including an effective amount of dihydroberberine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, for anti-aging, especially ameliorating or preventing skin aging, cellular senescence, or photoaging through inhibiting progerin in a mammal.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61Q 19/08 - Préparations contre le vieillissement
A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
99.
Use of dihydroberberine or its derivatives to enhance muscle function
The present invention provides novel methods for enhancing muscle function in a mammal, the method includes administration to the mammal of a composition comprising therapeutically effective amount of dihydroberberine (DHB) or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. The present invention also provides a composition including therapeutically effective amount of dihydroberberine (DHB) or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, for enhancing muscle function. In addition, the present invention provides methods for preparing any compositions disclosed herein.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Chemical additives for use in the manufacture of dietary supplements; Glycerine for use in the manufacture of dietary supplements; Glycerol for use in the manufacture of dietary supplements; Vitamins for the food industry; Vitamins for use in the manufacture of food supplements.
