A high-shear mixing chamber is provided having a single wide slot microchannel that enables a higher throughput, less plugging, and a longer life (e.g., less wear). The provided mixing chamber may include an inlet and an outlet in fluid communication with a single wide slot microchannel (e.g., via an inlet and outlet plenum). In some aspects, the wide slot microchannel may have a stepped interior such that the wide slot microchannel has portions with different depths. The wide slot microchannel has a first surface opposite a second surface and one or more steps may be formed with the first surface, the second surface, or with both the first surface and second surface.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Laboratory apparatus and instruments, namely, homogenizers; Cell disrupter machines in the nature of laboratory chemical reactors and particle accelerators; Pumper Machines in the nature of laboratory homogenizers; Micro-processors for cell disruption
A new and innovative high-pressure priming valve is provided for use in high-pressure fluid systems that require a high level of fluid purity. The priming valve includes at least three ports, some of which are angled. The priming valve also includes a needle that variably blocks and unblocks a pathway to one of the ports between normal operation and a priming operation, respectively. The priming valve includes a sealing insert positioned below a stack of washers that maintain the needle's alignment in response to high fluid pressures exerted on the needle. The sealing insert helps prevent fluid from contacting the stack of washers, which helps prevent biological growth within the valve. The angled ports help facilitate priming valve drainage to further help prevent biological growth. By helping prevent biological growth, the sealing insert helps prevent fluid contamination and enables the priming valve to be utilized for high-purity fluid applications.
F16K 31/50 - Moyens mécaniques d'actionnement à tige-guide filetée
F16K 41/02 - Joints d'étanchéité pour tiges avec un presse-étoupe
F16D 9/02 - Accouplements avec organe de sécurité pour le désaccouplement par des moyens thermiques, p. ex. un élément fusible
F16K 1/12 - Soupapes ou clapets, c.-à-d. dispositifs obturateurs dont l'élément de fermeture possède au moins une composante du mouvement d'ouverture ou de fermeture perpendiculaire à la surface d'obturation à corps de soupape profilé autour duquel le fluide s'écoule quand la soupape est ouverte
F04D 9/06 - Utilisation de pompes d'amorçageUtilisation de pompes de surpression pour éviter le blocage par la vapeur du type à jet
F04D 9/04 - Utilisation de pompes d'amorçageUtilisation de pompes de surpression pour éviter le blocage par la vapeur
F16K 24/04 - Dispositifs, p. ex. soupapes, pour la mise à l'air libre ou l'aération d'enceintes pour la mise à l'air libre uniquement
The present application provides new and innovative high-pressure fluid systems for preventing seal burning due to gas auto-ignition. The provided systems include an o-ring disposed within a seal cavity of a cup seal to decrease the dead volume in the seal cavity. By reducing the dead volume, the o-ring decreases the volume of gas that is able to accumulate and thus helps prevent the gas from auto-igniting as the gas is compressed. By preventing the gas from auto-igniting, the provided system helps prevent seal burning, which helps prevent premature cup seal failure and prevent fluid contamination.
F04B 19/02 - "Machines" ou pompes ayant des caractéristiques particulières non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes ayant des cylindres mobiles
F04B 37/20 - Pompes spécialement adaptées aux fluides compressibles et ayant des caractéristiques pertinentes non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes pour utilisation particulière pour fluides élastiques particuliers pour gaz humides, p. ex. de l'air
F04B 47/12 - Pompes ou installations de pompage spécialement adaptées pour élever un fluide à partir d'une grande profondeur, p. ex. pompes de puits élevant le fluide à pomper jusqu'à la surface au moyen d'un piston libre
09 - Appareils et instruments scientifiques et électriques
Produits et services
Chromatography apparatus for laboratory use; Scientific apparatus, namely, pressure relief valves, micro chemical reactors and microarrays for laboratory and industrial use; Solid phase extraction cartridges for laboratory and industrial use; Scientific apparatus, namely, homogenizers, particle accelerators and particle extractors for use in the laboratory, research, science and industrial use
09 - Appareils et instruments scientifiques et électriques
Produits et services
Chromatography apparatus for laboratory use; Scientific apparatus, namely, back pressure valves, micro chemical reactors and microarrays for laboratory and industrial use; Solid phase extraction cartridges for laboratory and industrial use; Scientific apparatus, namely, homogenizers, particle accelerators and particle extractors for use in the laboratory, research, science and industrial use
09 - Appareils et instruments scientifiques et électriques
Produits et services
Chromatography apparatus for laboratory use; Scientific apparatus, namely, pressure relief valves, micro chemical reactors and microarrays for laboratory and industrial use; Solid phase extraction cartridges for laboratory and industrial use; Scientific apparatus, namely, homogenizers and particle extractors for use in the science and research industry; Laboratory and scientific apparatus and instruments, namely, homogenizers and particle accelerators
09 - Appareils et instruments scientifiques et électriques
Produits et services
Chromatography apparatus for laboratory use; Scientific apparatus, namely, pressure relief valves, micro chemical reactors and microarrays for laboratory and industrial use; Solid phase extraction cartridges for laboratory and industrial use; Scientific apparatus, namely, homogenizers and particle extractors for use in the science and research industry; Laboratory and scientific apparatus and instruments, namely, homogenizers and particle accelerators
09 - Appareils et instruments scientifiques et électriques
Produits et services
Chromatography apparatus for laboratory use; Scientific apparatus, namely, pressure relief valves, micro chemical reactors and microarrays for laboratory and industrial use; Solid phase extraction cartridges for laboratory and industrial use; Scientific apparatus, namely, homogenizers and particle extractors for use in the science and research industry; Laboratory and scientific apparatus and instruments, namely, homogenizers and particle accelerators
10.
APPARATUSES AND METHODS USING HIGH PRESSURE DUAL CHECK VALVE
Apparatuses and methods related to a high pressure fluid processing device having a dual check valve setup that can be quickly and easily maintained with replacement parts are disclosed herein. In a general example embodiment, a high pressure processing device includes a body including a first surface having a first recess, a second surface having a second recess, and a third surface having a third recess, a first subassembly including a first check valve at least partially inserted into the first recess, a second subassembly including a second check valve at least partially inserted into the second recess, and a third subassembly coupling the body to a fluid driving mechanism at least partially inserted into the third recess, wherein the first subassembly, second subassembly and third subassembly are configured to be independently attachable to and detachable from the first recess, second recess and third recess, respectively.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Laboratory equipment for mixing, emulsification, homogenization, chemical process reaction, control and acceleration, controlled crystallization, cell disruption and nanoparticle manufacture.
12.
HIGH-PRESSURE FLUID PROCESSING DEVICE CONFIGURED FOR BATCH PROCESSING
The present disclosure provides apparatuses and methods related to a high pressure processing device that is configured to simplify batch processing. In an embodiment, a high pressure processing device includes a processing module configured to reduce a particle size of a material or achieve a desired liquid processing result for the material, a pump configured to pump the material to an inlet of the processing module, a recirculation pathway configured to recirculate the material from an outlet of the processing module back to the pump, an input device configured to receive at least one user input variable, and a controller configured to (i) determine a number of pump strokes for the pump based on the user input variable, and (ii) control the pump according to the determined number of pump strokes so that the material makes a plurality of passes through the processing module.
F04B 49/20 - Commande des "machines", pompes ou installations de pompage ou mesures de sécurité les concernant non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes en modifiant la vitesse d'entraînement
F04B 49/24 - Commande des "machines", pompes ou installations de pompage ou mesures de sécurité les concernant non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes par clapets de dérivation
F04C 14/06 - Commande, surveillance ou dispositions de sécurité pour "machines" ou pompes ou installations de pompage spécialement adaptées pour arrêter, pour démarrer, pour le ralenti ou pour un fonctionnement à charge nulle
F04C 14/08 - Commande, surveillance ou dispositions de sécurité pour "machines" ou pompes ou installations de pompage caractérisées par une variation de la vitesse de rotation
F04C 28/06 - Commande, surveillance ou dispositions de sécurité pour les pompes ou les installations de pompage spécialement adaptées pour les fluides compressibles spécialement adaptées pour arrêter, pour démarrer, pour le ralenti ou pour un fonctionnement à charge nulle
F04C 28/08 - Commande, surveillance ou dispositions de sécurité pour les pompes ou les installations de pompage spécialement adaptées pour les fluides compressibles caractérisées par une variation de la vitesse de rotation
G01F 11/02 - Appareils qu'il faut actionner de l'extérieur, adaptés à chaque opération répétée et identique, pour mesurer et séparer le volume prédéterminé d'un fluide ou d'un matériau solide fluent à partir d'une alimentation ou d'un récipient sans tenir compte du poids, et pour fournir ce volume avec chambres de mesure qui se dilatent ou se contractent au cours du mesurage
B01J 4/00 - Dispositifs d'alimentationDispositifs de commande d'alimentation ou d'évacuation
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Laboratory equipment for mixing, emulsification, homogenization, chemical process reaction, control and acceleration, controlled crystallization, cell disruption and nanoparticle manufacture (1) Consulting services in the fields of chemical research and development, chemical engineering and process development, biotechnology process development; pharmaceutical manufacture, nanoparticle manufacture
Apparatuses and methods that reduce cavitation in interaction chambers are described herein. In an embodiment, for a fluid processor or fluid homogenizer, preferably a high shear processor or a high pressure homogenizer, includes an inlet chamber, preferably an inlet cylinder, and an outlet cylinder, wherein an entrance to the microchannel from the inlet chamber is offset a distance from the bottom end of the inlet chamber, and at least one of: (i) at least one tapered fillet located on at least one side wall of the microchannel at the microchannel entrance; (ii) at least one side wall of the microchannel converging inwardly from the inlet chamber to the outlet chamber; (iii) at least one of a top wall and a bottom wall of the microchannel angled from the inlet chamber to the outlet chamber; and (iv) a top fillet that extends around a diameter of inlet chamber.
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
[Chromatography apparatus for laboratory use;] laboratory apparatus, namely, [centrifuges,] chemical reactors, [spectroscopes and microarrays; solid phase extraction cartridges for laboratory use; scientific apparatus, namely, cellular mixed ester membranes for use in the science and research industry;] laboratory apparatus and instruments, namely, homogenizers; particle accelerators Chemical analysis, engineering and research; research and development in the pharmaceutical and biotechnology fields; consulting services in the fields of biotechnology, pharmaceutical research and development, laboratory testing and pharmacogenetics
(1) Emulsifier units, namely processors for particle size reduction used to make liposomes and emulsions for use in various applications through the interaction of liquid streams in defined microchannels.
17.
COMPACT INTERACTION CHAMBER WITH MULTIPLE CROSS MICRO IMPINGING JETS
A mixing assembly includes an inlet, an outlet and a mixing chamber, the inlet is fluidly connected to the outlet through a plurality of micro fluid flow paths in a direction perpendicular from the inlet. The micro fluid flow paths fluidly connect to the perpendicular inlet via a transition portion. The micro fluid flow paths are constructed radially inwardly to a concentration area in the mixing chamber. By directing multiple fluid flows to a concentrated area within the mixing chamber at high speeds, the energy dissipated at the point of collision is maximized, which helps to increase consistency and quality of mixing, and to reduce particle size of the fluid in the mixing chamber.
A mixing assembly includes an inlet, an outlet and a mixing chamber, the inlet is fluidly connected to the outlet through a plurality of micro fluid flow paths in a direction perpendicular from the inlet. The micro fluid flow paths fluidly connect to the perpendicular inlet via a curved transition portion. The curved transition portion provides a more efficient flow path for the fluid to travel from the inlet to the micro fluid flow paths to the mixing chamber. By transitioning the direction change, flow resistance is decreased, and the fluid flow rate and shear rate is increased. Increased fluid flow rate and shear rate helps to increase consistency and quality of mixing, and to reduce particle size of the fluid in the mixing chamber.
A compact interaction chamber is used to cause high shear, impact forces, and cavitation to reduce particle size and mix fluids while reducing waste and holdup volume. A first housing made of stainless steel holds an inlet mixing chamber element and an outlet mixing chamber element in a female bore using thermal expansion. The inlet and outlet mixing chamber elements are manufactured so that the diameter of the cooled female bore is slightly smaller than the diameter of the mixing chamber elements. The first housing is heated, expanding the diameter of the female bore enough to allow the inlet and outlet mixing chamber elements to be inserted. After the mixing chamber elements are inserted and aligned within the female bore, the first housing is allowed to cool. Once cooled, the female bore contracts and applies sufficient hoop stress to securely hold the mixing chamber elements during high shear force mixing.
Apparatus, systems and methods are provided that utilize microreactor technology to achieve desired mixing and interaction at a micro and/or molecular level between and among feed stream constituents. Feed streams are fed to an intensifier pump at individually controlled rates, e.g., based on operation of individually controlled feed pumps. The time during which first and second feed streams are combined/mixed prior to introduction to the microreactor is generally minimized, thereby avoiding potential reactions and other constituent interactions prior to micro- and/or nano-scale interactions within the microreactor. Various microreactor designs/geometries may be employed, e.g., "Z" type single or multi-slot geometries and "Y" type single or multi-slot geometries. Various applications benefit from the disclosure, including emulsion, crystallization, encapsulation and reaction processes.
B82B 3/00 - Fabrication ou traitement des nanostructures par manipulation d’atomes ou de molécules, ou d’ensembles limités d’atomes ou de molécules un à un comme des unités individuelles
21.
APPARATUSES AND METHODS USING HIGH PRESSURE DUAL CHECK VALVE
Apparatuses and methods related to a high pressure fluid processing device having a dual check valve setup that can be quickly and easily maintained with replacement parts are disclosed herein. In a general example embodiment, a high pressure processing device includes a body including a first surface having a first recess, a second surface having a second recess, and a third surface having a third recess, a first subassembly including a first check valve at least partially inserted into the first recess, a second subassembly including a second check valve at least partially inserted into the second recess, and a third subassembly coupling the body to a fluid driving mechanism at least partially inserted into the third recess, wherein the first subassembly, second subassembly and third subassembly are configured to be independently attachable to and detachable from the first recess, second recess and third recess, respectively.
(57) Abstract: The present disclosure provides apparatuses and methods related to a high pressure processing device that is configured to simplify batch processing. In an embodiment, a high pressure processing device includes a processing module configured to reduce a particle size of a material or achieve a desired liquid processing result for the material, a pump configured to pump the material to an inlet of the processing module, a recirculation pathway configured to recirculate the material from an outlet of the processing module back to the pump, an input device configured to receive at least one user input variable, and a controller configured to (i) determine a number of pump strokes for the pump based on the user input variable, and (ii) control the pump according to the determined number of pump strokes so that the material makes a plurality of passes through the processing module.
F04B 49/20 - Commande des "machines", pompes ou installations de pompage ou mesures de sécurité les concernant non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes en modifiant la vitesse d'entraînement
F04B 49/24 - Commande des "machines", pompes ou installations de pompage ou mesures de sécurité les concernant non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes par clapets de dérivation
F04C 14/06 - Commande, surveillance ou dispositions de sécurité pour "machines" ou pompes ou installations de pompage spécialement adaptées pour arrêter, pour démarrer, pour le ralenti ou pour un fonctionnement à charge nulle
F04C 14/08 - Commande, surveillance ou dispositions de sécurité pour "machines" ou pompes ou installations de pompage caractérisées par une variation de la vitesse de rotation
F04C 28/06 - Commande, surveillance ou dispositions de sécurité pour les pompes ou les installations de pompage spécialement adaptées pour les fluides compressibles spécialement adaptées pour arrêter, pour démarrer, pour le ralenti ou pour un fonctionnement à charge nulle
F04C 28/08 - Commande, surveillance ou dispositions de sécurité pour les pompes ou les installations de pompage spécialement adaptées pour les fluides compressibles caractérisées par une variation de la vitesse de rotation
G01F 11/02 - Appareils qu'il faut actionner de l'extérieur, adaptés à chaque opération répétée et identique, pour mesurer et séparer le volume prédéterminé d'un fluide ou d'un matériau solide fluent à partir d'une alimentation ou d'un récipient sans tenir compte du poids, et pour fournir ce volume avec chambres de mesure qui se dilatent ou se contractent au cours du mesurage
23.
APPARATUS AND METHODS FOR NANOPARTICLE GENERATION AND PROCESS INTENSIFICATION OF TRANSPORT AND REACTION SYSTEMS
Apparatus, systems and methods are provided that utilize microreactor technology to achieve desired mixing and interaction at a micro and/or molecular level between and among feed stream constituents. Feed streams are fed to an intensifier pump at individually controlled rates, e.g., based on operation of individually controlled feed pumps. The time during which first and second feed streams are combined/mixed prior to introduction to the microreactor is generally minimized, thereby avoiding potential reactions and other constituent interactions prior to micro- and/or nano-scale interactions within the microreactor. Vari-ous microreactor designs/geometries may be employed, e.g., "Z" type single or multi-slot geometries and "Y" type single or multi--slot geometries. Various applications benefit from the disclosure, including emulsion, crystallization, encapsulation and reaction processes.
The present application provides new and innovative high-pressure fluid systems for preventing seal burning due to gas auto-ignition. The provided systems include an o-ring disposed within a seal cavity of a cup seal to decrease the dead volume in the seal cavity. By reducing the dead volume, the o-ring decreases the volume of gas that is able to accumulate and thus helps prevent the gas from auto-igniting as the gas is compressed. By preventing the gas from auto-igniting, the provided system helps prevent seal burning, which helps prevent premature cup seal failure and prevent fluid contamination.
F04B 19/02 - "Machines" ou pompes ayant des caractéristiques particulières non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes ayant des cylindres mobiles
F04B 37/20 - Pompes spécialement adaptées aux fluides compressibles et ayant des caractéristiques pertinentes non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes pour utilisation particulière pour fluides élastiques particuliers pour gaz humides, p. ex. de l'air
F04B 47/12 - Pompes ou installations de pompage spécialement adaptées pour élever un fluide à partir d'une grande profondeur, p. ex. pompes de puits élevant le fluide à pomper jusqu'à la surface au moyen d'un piston libre
Apparatuses and methods that reduce cavitation in interaction chambers are described herein. In an embodiment, for a fluid processor or fluid homogenizer, preferably a high shear processor or a high pressure homogenizer, includes an inlet chamber, preferably an inlet cylinder, and an outlet cylinder, wherein an entrance to the microchannel from the inlet chamber is offset a distance from the bottom end of the inlet chamber, and at least one of: (i) at least one tapered fillet located on at least one side wall of the microchannel at the microchannel entrance; (ii) at least one side wall of the microchannel converging inwardly from the inlet chamber to the outlet chamber; (iii) at least one of a top wall and a bottom wall of the microchannel angled from the inlet chamber to the outlet chamber; and (iv) a top fillet that extends around a diameter of inlet chamber.
A new and innovative high-pressure priming valve is provided for use in high-pressure fluid systems that require a high level of fluid purity. The priming valve includes at least three ports, some of which are angled. The priming valve also includes a needle that variably blocks and unblocks a pathway to one of the ports between normal operation and a priming operation, respectively. The priming valve includes a sealing insert positioned below a stack of washers that maintain the needle's alignment in response to high fluid pressures exerted on the needle. The sealing insert helps prevent fluid from contacting the stack of washers, which helps prevent biological growth within the valve. The angled ports help facilitate priming valve drainage to further help prevent biological growth. By helping prevent biological growth, the sealing insert helps prevent fluid contamination and enables the priming valve to be utilized for high-purity fluid applications.
F04D 9/04 - Utilisation de pompes d'amorçageUtilisation de pompes de surpression pour éviter le blocage par la vapeur
F04D 9/06 - Utilisation de pompes d'amorçageUtilisation de pompes de surpression pour éviter le blocage par la vapeur du type à jet
F16D 9/02 - Accouplements avec organe de sécurité pour le désaccouplement par des moyens thermiques, p. ex. un élément fusible
F16K 1/12 - Soupapes ou clapets, c.-à-d. dispositifs obturateurs dont l'élément de fermeture possède au moins une composante du mouvement d'ouverture ou de fermeture perpendiculaire à la surface d'obturation à corps de soupape profilé autour duquel le fluide s'écoule quand la soupape est ouverte
F16K 24/04 - Dispositifs, p. ex. soupapes, pour la mise à l'air libre ou l'aération d'enceintes pour la mise à l'air libre uniquement
F16K 31/50 - Moyens mécaniques d'actionnement à tige-guide filetée
F16K 41/02 - Joints d'étanchéité pour tiges avec un presse-étoupe
