Abrégé

The present invention relates to a microorganism genetically modified for the production of leucine and/or isoleucine, wherein said microorganism comprises the expression of a heterologous gapN gene coding an NADP-dependent glyceralde-O hyde-3-phosphate dehydrogenase, and the attenuation of the expression of gapA and gltA genes as compared to an unmodified microorganism. The present invention also relates to a method for the production of leucine and/or isoleucine using said microorganism.

Classes IPC  ?

• C12N 1/20 - BactériesLeurs milieux de culture
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12R 1/19 - Escherichia coli

Abrégé

The present invention relates to a process for the extraction and purification of ectoine from a fermentation broth, comprising at least the successive steps of: a) Passing said fermentation broth through a cation exchange resin able to capture ectoine, and eluting ectoine, to obtain an ectoine aqueous solution; b) Concentrating said ectoine aqueous solution and then drying it, to obtain raw crystals of ectoine; c) Dissolving said raw crystals of ectoine into hot methanol; d) Hot filtrating said methanol-ectoine mixture; e) Crystallizing ectoine by cooling of the filtered methanol-ectoine mixture and recovering high purity ectoine crystals.

Classes IPC  ?

• C12P 13/04 - Alpha- ou bêta-amino-acides
• C07C 227/40 - SéparationPurification
• C07C 227/42 - Cristallisation
• C12P 17/12 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'azote comme unique hétéro-atome du cycle contenant un hétérocycle à six chaînons
• C07D 239/06 - Composés hétérocycliques contenant des cycles diazine-1, 3 ou diazine-1, 3 hydrogéné non condensés avec d'autres cycles comportant une liaison double entre chaînons cycliques ou entre chaînon cyclique et chaînon non cyclique

Abrégé

The present invention relates to a microorganism genetically modified for improved production of valine, wherein the microorganism overexpresses a ilvA gene coding a threonine deaminase and/or exhibits an increased threonine deaminase activity and comprises a mutated argP gene coding DNA-binding transcriptional dual regulator. The present invention also relates to a method for the production of valine using said microorganism.

Classes IPC  ?

• C12P 13/08 - LysineAcide diaminopiméliqueThréonineValine
• C07K 14/245 - Escherichia (G)
• C12N 9/88 - Lyases (4.)

Abrégé

The invention relates to OTM of amino acid and minerals, the unique structure of rendering them useful in human and animal feed so as to improve in vivo bioavailability and assimilation of mineral sources.

Classes IPC  ?

• C07C 229/26 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant plus d'un groupe amino lié au squelette carboné, p. ex. lysine
• A23K 20/142 - Acides aminésLeurs dérivés
• A23K 50/75 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les oiseaux pour la volaille
• A23K 20/24 - Composés de métaux alcalino-terreux, p. ex. de magnesium
• A23K 50/30 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les porcs
• A23K 50/80 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les animaux aquatiques, p. ex. pour les poissons, les crustacés ou les mollusques
• A23K 20/20 - Substances inorganiques, p. ex. oligo-éléments

Abrégé

The invention relates to encapsulated amino acid(s) for their use in promoting health, in particular digestive health, in monogastric farm animals.

Classes IPC  ?

• A23K 20/142 - Acides aminésLeurs dérivés
• A23K 20/158 - Acides grasGraissesProduits contenant des huiles ou des graisses
• A23K 40/30 - Mise en forme ou traitement des produits alimentaires pour animaux par encapsulationMise en forme ou traitement des produits alimentaires pour animaux par revêtement
• A23K 50/75 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les oiseaux pour la volaille

Abrégé

gapNsdaAsdaBsdaB gene(s) as compared to an unmodified microorganism. The present invention also relates to a method for the production of serine and/or cysteine using said microorganism.

Classes IPC  ?

• C07K 14/245 - Escherichia (G)

Abrégé

The present invention relates to a microorganism genetically modified for improved production of alanine, wherein the microorganism expresses a heterologous alaD gene coding an alanine dehydrogenase and has reduced Lrp transcription factor activity and/or expression. The present invention also relates to a method for the production of alanine using said microorganism.

Classes IPC  ?

• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• C12P 13/06 - AlanineLeucineIsoleucineSérineHomosérine

Abrégé

gapNgapAgltAgltA genes as compared to an unmodified microorganism. The present invention also relates to a method for the production of leucine and/or isoleucine using said microorganism.

Classes IPC  ?

• C07K 14/34 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Corynebacterium (G)

Produits et services

Chemical products for use in industry, science as well as in agriculture, horticulture and forestry; composts, manures, fertilizers; biological preparations for use in industry and science; all the aforesaid goods predominantly containing amino acids or organic acids obtained by fermentation or derivatives thereof. Medical and veterinary preparations; dietetic substances and foodstuffs for medical or veterinary use, food for babies; dietary supplements for humans and animals; all the aforesaid goods predominantly containing amino acids or organic acids obtained by fermentation. Foodstuffs and beverages for animals containing amino acids or organic acids obtained by fermentation.

Produits et services

Chemical products for use in industry, science as well as in agriculture, horticulture and forestry; composts, manures, fertilizers; biological preparations for use in industry and science; all the aforesaid goods predominantly containing amino acids or organic acids obtained by fermentation or derivatives thereof. Veterinary preparations; dietetic substances and foods for veterinary use; food supplements for animals; all the aforesaid goods predominantly containing amino acids or organic acids obtained by fermentation. Foodstuffs and beverages for animals containing amino acids or organic acids obtained by fermentation.

Produits et services

Chemical products for use in industry, science as well as in agriculture, horticulture and forestry; composts, manures, fertilizers; biological preparations for use in industry and science; all the aforesaid goods predominantly containing amino acids or organic acids obtained by fermentation or derivatives thereof. Veterinary preparations; dietetic substances and foods for veterinary use; food supplements for animals; all the aforesaid goods predominantly containing amino acids or organic acids obtained by fermentation. Foodstuffs and beverages for animals containing amino acids or organic acids obtained by fermentation.

Produits et services

(1) Produits chimiques sous forme de préparations chimiques destinées à l'industrie, à la science ainsi qu'à l'agriculture, l'horticulture et la sylviculture destinés à la préparation d'aliments pour animaux et à la préparation de compléments alimentaires et diététiques pour animaux ; composts, engrais, fertilisants; préparations biologiques destinées à l'industrie et aux sciences à base de lysine et de minéraux destinés à la préparation d'aliments pour animaux et à la préparation de compléments alimentaires et diététiques pour animaux ; tous les produits précités contenant majoritairement des acides aminés ou des acides organiques obtenus par fermentation ou leurs dérivés. (2) Préparations à base d'acides aminés à usage vétérinaire; aliments et substances diététiques à usage vétérinaire, nommément acide aminés à base de lysine et de minéraux destinés à la préparation d'aliments pour animaux et à la préparation de compléments alimentaires et diététiques pour animaux ; compléments alimentaires pour animaux de rente à base de lysine et de minéraux destinés à la préparation d'aliments pour animaux; tous les produits précités contenant majoritairement des acides aminés ou des acides organiques obtenus par fermentation. (3) Produits alimentaires et boissons pour animaux contenant des acides aminés ou acides organiques obtenus par fermentation.

Produits et services

Chemical products in the nature of chemical preparations for use in industry, science as well as in agriculture, horticulture and forestry; composts, manures, fertilizers; biological preparations for use in industry and science; all the aforesaid goods predominantly containing amino acids or organic acids obtained by fermentation or derivatives thereof Veterinary preparations, for pets, poultry, cattle; dietetic substances and foods being dietary supplement for pets, poultry, cattle for veterinary use; dietary food supplements for animals; all the aforesaid goods predominantly containing amino acids or organic acids obtained by fermentation Foodstuffs and beverages for animals containing amino acids or organic acids obtained by fermentation

Abrégé

ilvAargPargP gene coding DNA-binding transcriptional dual regulator. The present invention also relates to a method for the production of valine using said microorganism.

Classes IPC  ?

• C12P 13/08 - LysineAcide diaminopiméliqueThréonineValine
• C12N 9/88 - Lyases (4.)
• C12R 1/19 - Escherichia coli
• C07K 14/245 - Escherichia (G)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes

Abrégé

The present invention relates to a microorganism genetically modified for production of ectoine, wherein said microorganism comprises the following modifications: expression of a heterologous gene ectA encoding a diaminobutyric acid acetyltransferase having at least 90% similarity with SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or SEQ ID NO: 5, a heterologous gene ectB encoding a diaminobutyric acid aminotransferase having at least 90% similarity with SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9 or SEQ ID NO: 10, a heterologous gene ectC encoding an ectoine synthase having at least 90% similarity with SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14 or SEQ ID NO: 15 and deletion of pykA and pykF genes. The present invention also relates to a method for the production of ectoine using said microorganism.

Classes IPC  ?

• C12P 17/12 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'azote comme unique hétéro-atome du cycle contenant un hétérocycle à six chaînons
• C12N 9/10 - Transférases (2.)

Produits et services

Preparations based on amino acids for nutritional use for animals, food additives based on amino acids as food supplements [not for medical use]; food supplements for animals based on amino acids; food supplements based on amino acids for livestock; food additives based on amino acids for livestock for supplementing animal food; food additives based on amino acids for livestock for veterinary use.

Abrégé

The present invention relates to a modified dehydrogenase, wherein one or more amino acid residues of the dehydrogenase are modified as compared to an unmodified dehydrogenase, and wherein the modified dehydrogenase has an increased ratio of leucine dehydrogenase or isoleucine dehydrogenase activity to valine dehydrogenase activity as compared to the unmodified dehydrogenase, and applications thereof.

Classes IPC  ?

• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• C12P 13/04 - Alpha- ou bêta-amino-acides

Produits et services

Chemical products in the nature of chemical preparations for use in industry, science as well as in agriculture, horticulture and forestry; composts, manures, fertilizers; biological preparations for use in industry and science; all the aforesaid goods predominantly containing amino acids or organic acids obtained by fermentation or derivatives thereof Veterinary preparations, for pets, poultry, cattle; dietetic substances and foods being dietary supplement for pets, poultry, cattle for veterinary use; dietary food supplements for animals; all the aforesaid goods predominantly containing amino acids or organic acids obtained by fermentation Foodstuffs and beverages for animals containing amino acids or organic acids obtained by fermentation

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastic materials; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use. Scientific and technological services as well as research and design services relating thereto; analysis and research and development services; scientific and technical research; design of goods for third parties; research and reports in the fields of science and technology, scientific concepts.

Produits et services

Chemicals used in industry, science and Chemical additives for use in industry, science and Chemicals used in agriculture, horticulture and forestry and Chemical adjuvants for use in agriculture, horticulture and forestry In particular basic organic chemicals, industrial fermentation chemicals, biochemicals, Bio sourced chemicals Other than the following goods: fungicides, herbicides, insecticides and Parasiticides; Chemicals and Chemical additives Not for medical or veterinary use For the manufacture of polymers, cosmetics, perfumes, food flavourings, food; Synthetic resins, unprocessed; Polymer resins, unprocessed; Unprocessed plastics; Adhesives for use in industry; Compost, manures, fertilizers; Biological preparations for use in industry and science Not for medical or veterinary use. Scientific and technological services and research and design relating thereto; Industrial analysis, research and development services; Scientific and technical research; Design of goods, for others; Research and reports in relation to the following fields: Provision of teaching classes, technology and Scientific design services.

Produits et services

Advertising; dissemination of advertising material (flyers, prospectuses, printed matter, samples) on paper media or digital media; marketing on the Internet; advertising via electronic means and particularly via the Internet; organization of exhibitions for commercial or advertising purposes; public relations. Education; training; information with respect to education; publication of books; organization of competitions (education or entertainment); organization and conducting of colloquiums, conferences or congresses; organization of exhibitions for cultural or educational purposes; electronic publication of books and journals online; teaching. Scientific and technological services and research and design relating thereto; analysis and research and development services; scientific and technical research; product designs for others; research and reports in the fields of science and technology, scientific concepts relating to amino acids and food for humans and animals.

Abrégé

The present invention relates to a microorganism genetically modified for improved production of alanine, wherein the microorganism expresses a heterologous alaD gene coding an alanine dehydrogenase and has reduced Lrp transcription factor activity and/or expression. The present invention also relates to a method for the production of alanine using said microorganism.

Classes IPC  ?

• C12R 1/145 - Clostridium
• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• C12P 13/06 - AlanineLeucineIsoleucineSérineHomosérine
• C12R 1/15 - Corynebacterium
• C12R 1/19 - Escherichia coli

Produits et services

Preparations based on amino acids for nutritional use for animals, food additives based on amino acids as food supplements [not for medical use]; food supplements for animals based on amino acids; food supplements based on amino acids for livestock; food additives based on amino acids for livestock for supplementing animal food; food additives based on amino acids for livestock for veterinary use.

Produits et services

Food additives as food supplements [not for medical use]; food supplements for animals; feed supplements for livestock (production animals); livestock feed additives to supplement animal food; feed additives for livestock for veterinary use. Protein-enriched food for animal consumption; animal foodstuffs; animal fattening products; grains for animal consumption; yeast for animal consumption; salt for cattle. Processing of food and processing of food additives for animals.

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastic materials; adhesives for use in industry; compost, manures, fertilizing products; biological preparations for industrial and scientific use other than for medical or veterinary use. Non-medicated cosmetic preparations and cosmetic products; non-medicated toilet preparations; non-medicated dentifrices; perfumery products and perfumes, essential oils; bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations. Pharmaceutical products, medical and veterinary preparations; dietetic food and substances for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use; products for destroying vermin; fungicides, herbicides. Food flavorings, other than essential oils. Food products and beverages for animals.

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastic materials; adhesives for use in industry; compost, manures, fertilizing products; biological preparations for industrial and scientific use other than for medical or veterinary use. Non-medicated cosmetic preparations and cosmetic products; non-medicated toilet preparations; non-medicated dentifrices; perfumery products and perfumes, essential oils; bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations. Pharmaceutical products, medical and veterinary preparations; dietetic food and substances for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use; products for destroying vermin; fungicides, herbicides. Food flavorings, other than essential oils. Food products and beverages for animals.

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastic materials; adhesives for use in industry; compost, manures, fertilizing products; biological preparations for industrial and scientific use other than for medical or veterinary use. Non-medicated cosmetic preparations and cosmetic products; non-medicated toilet preparations; non-medicated dentifrices; perfumery products and perfumes, essential oils; bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations. Pharmaceutical products, medical and veterinary preparations; dietetic food and substances for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use; products for destroying vermin; fungicides, herbicides. Food flavorings, other than essential oils. Food products and beverages for animals.

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastic materials; adhesives for use in industry; compost, manures, fertilizing products; biological preparations for industrial and scientific use other than for medical or veterinary use. Non-medicated cosmetic preparations and cosmetic products; non-medicated toilet preparations; non-medicated dentifrices; perfumery products and perfumes, essential oils; bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations. Pharmaceutical products, medical and veterinary preparations; dietetic food and substances for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use; products for destroying vermin; fungicides, herbicides. Food flavorings, other than essential oils. Food products and beverages for animals.

Produits et services

(1) Arômes alimentaires, autres qu'huiles essentielles, composés d'acides organiques, de produits chimiques, produits par la fermentation. (2) Aliments pour animaux d'élevage, boissons pour animaux d'élevage; aliments pour animaux de compagnie, boissons pour animaux de compagnie.

Produits et services

Food flavorings, other than essential oils Foodstuffs and beverages for animals

Produits et services

(1) Produits chimiques à usage industriel, agents biochimiques à usage industriel, produits chimiques pour la science, agents biochimiques pour la science, produits chimiques agricoles, agents biochimiques agricoles, produits chimiques horticoles, agents biochimiques horticoles, produits chimiques pour la sylviculture, agents biochimiques pour la sylviculture nommément produits chimiques de fermentation industrielle et produits chimiques biosourcés, nommément constituants de produits phytosanitaires, des engrais, des produits agrochimiques tels que des fertilisants, produits chimiques organiques de base et produits chimiques d'origine biologique, nommément acides aminés, molécules linéaires, molécules cycliques, molécules aromatiques comprenant au moins une fonction choisie parmi acide carboxylique, anhydride d'acide, ester, halogénure d'acide, amide, nitrile, aldéhyde, cétone, alcool, amine, ether oxyde, alcène, alcane ou organométallique; produits chimiques ou additifs chimiques pour la fabrication de polymères; produits chimiques ou additifs chimiques pour la fabrication de cosmétiques; produits chimiques ou additifs chimiques pour la fabrication de parfums; produits chimiques ou additifs chimiques pour la fabrication d'arômes alimentaires; produits chimiques ou additifs chimiques pour la fabrication de produits alimentaires; résines artificielles à l'état brut; résines polymères à l'état brut; matières plastiques à l'état brut; adhésifs pour utilisation dans l'industrie textile; adhésifs pour utilisation dans le domaine de la biochimie industrielle; composts, engrais, fertilisants. (2) Produits cosmétiques et préparations cosmétiques non médicamenteux, nommément produits de parfumerie et parfums, huiles essentielles à usage cosmétique, préparations pour blanchir à usage cosmétique, crème nettoyante à usage cosmétique, préparations dégraissantes pour utilisation sur la peau, abrasifs pour la peau, préparations de toilette non médicamenteuses, nommément dentifrices; poudre de blanchissage pour la lessive; préparations pour polir les ongles. (3) Préparations médicales, vétérinaires contenant des acides aminés ou des acides organiques à activité prébiotique, probiotique ou postbiotique; suppléments diététiques à base d'acides aminés, d'acides organiques employés chez les animaux d'élevage; compléments alimentaires pour êtres humains, pour animaux enrichis en acides aminés, en acides organiques; produits alimentaires enrichis en acides aminés, en acides organiques à usage médical, à usage vétérinaire; produits pour la destruction d'animaux nuisibles; fongicides, herbicides. (4) Arômes alimentaires, autres qu'huiles essentielles, composés d'acides organiques, de produits chimiques, produits par la fermentation. (5) Aliments pour animaux d'élevage, boissons pour animaux d'élevage; aliments pour animaux de compagnie, boissons pour animaux de compagnie.

Produits et services

Chemicals and chemical additives for use in industry, science as well as agriculture, horticulture and forestry, namely, basicorganic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourcedproducts excluding fungicides, herbicides, insecticides and parasiticides; chemicals and chemical additives other than for medicalor veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins;unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biologicalpreparations for industrial and scientific use other than for medical or veterinary use Non-medicated cosmetic preparations and cosmetics; non-medicated toilet preparations, namely, toilet water; non-medicateddentifrices; perfumery and perfumes, essential oils; bleaching preparations and other substances for laundry use, namely, laundrydetergents; cleaning, polishing, degreasing and abrasive preparations Pharmaceutical, medical and veterinary preparations for use in the treatment of metabolic, hormonal, cutaneous, dermatological,endocrine, cardiovascular, pulmonary, ophthalmic, gastrointestinal, infectious, viral, genetic, neurological, cancerous,musculoskeletal, hepatological, respiratory, psychiatric and immune system related diseases, disorders and conditions; dieteticfood and beverages adapted for medical or veterinary use; food supplements for humans and animals; dietetic foods enrichedwith nutritional elements adapted for medical or veterinary use; preparations for destroying vermin, fungicides, herbicides Food flavorings, other than essential oils Foodstuffs and beverages for animals

Produits et services

(1) Produits chimiques à usage industriel, agents biochimiques à usage industriel, produits chimiques pour la science, agents biochimiques pour la science, produits chimiques agricoles, agents biochimiques agricoles, produits chimiques horticoles, agents biochimiques horticoles, produits chimiques pour la sylviculture, agents biochimiques pour la sylviculture nommément produits chimiques de fermentation industrielle et produits chimiques biosourcés, nommément constituants de produits phytosanitaires, des engrais, des produits agrochimiques tels que des fertilisants, produits chimiques organiques de base et produits chimiques d'origine biologique, nommément acides aminés, molécules linéaires, molécules cycliques, molécules aromatiques comprenant au moins une fonction choisie parmi acide carboxylique, anhydride d'acide, ester, halogénure d'acide, amide, nitrile, aldéhyde, cétone, alcool, amine, ether oxyde, alcène, alcane ou organométallique; produits chimiques ou additifs chimiques pour la fabrication de polymères; produits chimiques ou additifs chimiques pour la fabrication de cosmétiques; produits chimiques ou additifs chimiques pour la fabrication de parfums; produits chimiques ou additifs chimiques pour la fabrication d'arômes alimentaires; produits chimiques ou additifs chimiques pour la fabrication de produits alimentaires; résines artificielles à l'état brut; résines polymères à l'état brut; matières plastiques à l'état brut; adhésifs pour utilisation dans l'industrie textile; adhésifs pour utilisation dans le domaine de la biochimie industrielle; composts, engrais, fertilisants. (2) Produits cosmétiques et préparations cosmétiques non médicamenteux, nommément produits de parfumerie et parfums, huiles essentielles à usage cosmétique, préparations pour blanchir à usage cosmétique, crème nettoyante à usage cosmétique, préparations dégraissantes pour utilisation sur la peau, abrasifs pour la peau, préparations de toilette non médicamenteuses, nommément dentifrices; poudre de blanchissage pour la lessive; préparations pour polir les ongles. (3) Préparations médicales, vétérinaires contenant des acides aminés ou des acides organiques à activité prébiotique, probiotique ou postbiotique; suppléments diététiques à base d'acides aminés, d'acides organiques employés chez les animaux d'élevage; compléments alimentaires pour êtres humains, pour animaux enrichis en acides aminés, en acides organiques; produits alimentaires enrichis en acides aminés, en acides organiques à usage médical, à usage vétérinaire; produits pour la destruction d'animaux nuisibles; fongicides, herbicides. (4) Arômes alimentaires, autres qu'huiles essentielles, composés d'acides organiques, de produits chimiques, produits par la fermentation. (5) Aliments pour animaux d'élevage, boissons pour animaux d'élevage; aliments pour animaux de compagnie, boissons pour animaux de compagnie.

Produits et services

Chemicals and chemical additives for use in industry, science as well as agriculture, horticulture and forestry, namely, basicorganic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourcedproducts excluding fungicides, herbicides, insecticides and parasiticides; chemicals and chemical additives other than for medicalor veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins;unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biologicalpreparations for industrial and scientific use other than for medical or veterinary use Non-medicated cosmetic preparations and cosmetics; non-medicated toilet preparations, namely, toilet water; non-medicateddentifrices; perfumery and perfumes, essential oils; bleaching preparations and other substances for laundry use, namely, laundrydetergents; cleaning, polishing, degreasing and abrasive preparations Pharmaceutical, medical and veterinary preparations for use in the treatment of metabolic, hormonal, cutaneous, dermatological,endocrine, cardiovascular, pulmonary, ophthalmic, gastrointestinal, infectious, viral, genetic, neurological, cancerous,musculoskeletal, hepatological, respiratory, psychiatric and immune system related diseases, disorders and conditions; dietetic food and beverages adapted for medical or veterinary use; food supplements for humans and animals; dietetic foods enriched with nutritional elements adapted for medical or veterinary use; preparations for destroying vermin, fungicides, herbicides Food flavorings, other than essential oils Foodstuffs and beverages for animals

Produits et services

Chemicals and chemical additives for use in industry, science as well as agriculture, horticulture and forestry namely basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemicals and chemical additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use Non-medicated cosmetic preparations and cosmetics; non-medicated toilet preparations namely toilet water; non-medicated dentifrices; perfumery and perfumes, essential oils; bleaching preparations and other substances for laundry use namely laundry detergents; cleaning, polishing, degreasing and abrasive preparations Pharmaceutical medical and veterinary preparations namely for treating metabolic, hormonal, cutaneous, dermatological, endocrine, cardiovascular, pulmonary, ophthalmic, gastrointestinal, infectious, viral, genetic, neurological, cancerous, musculoskeletal, hepatological, respiratory, psychiatric and immune system related diseases, disorders and conditions; dietetic food and beverages adapted for medical or veterinary use; food supplements for humans and animals; dietetic foods enriched with nutritional elements adapted for medical or veterinary use; preparations for destroying vermin; fungicides, herbicides Food flavorings, other than essential oils Foodstuffs and beverages for animals

Abrégé

C. sphenoides. As this modified strain may be adapted for growth and for the production of 1,3-propanediol in an appropriate culture medium with high glycerol content, the invention also relates to a method for the production of 1,3-propanediolandbutyric acid, by culturing at least this mutant strain in an appropriate culture medium.

Classes IPC  ?

• C12P 7/52 - Acide propioniqueAcides butyriques
• C07K 14/33 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Clostridium (G)
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C12P 7/18 - Polyols
• C12N 1/20 - BactériesLeurs milieux de culture

Abrégé

ectBectCpykApykFpykF genes. The present invention also relates to a method for the production of ectoine using said microorganism.

Classes IPC  ?

• C12P 17/12 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'azote comme unique hétéro-atome du cycle contenant un hétérocycle à six chaînons
• C12N 9/10 - Transférases (2.)
• C12N 9/88 - Lyases (4.)

Abrégé

Provided is a genetically modified microorganism for the production of a derivative of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3-propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,4-dihydroxybutyrate, the microorganism further having a gene coding for a mutant phosphoserine aminotransferase having an improved L-homoserine aminotransferase activity converting by transamination L-homoserine into 4-hydroxy-2-ketobutyrate. Also provided is a method for the production of derivatives of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3-propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,4-dihydroxybutyrate by culturing the genetically modified microorganism in a culture medium and recovering the desired derivative.

Classes IPC  ?

• C12N 15/20 - Interférons
• C12N 9/10 - Transférases (2.)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12P 7/18 - Polyols
• C12P 7/24 - Préparation de composés organiques contenant de l'oxygène contenant un groupe carbonyle
• C12P 7/42 - Acides hydroxycarboxyliques

Abrégé

The present invention concerns a new method for the production of 1,3-propanediol comprising culturing a recombinant microorganism converting glycerol into 1,3-propanediol and overexpressing the hcpR and/or frdX gene on a medium comprising glycerine. A recombinant microorganism for the production of 1,3 propanediol from glycerol, wherein said microorganism converts glycerol into 1,3-propanediol and 10 overexpresses the hcpR and/or the frdX gene.

Classes IPC  ?

• C12P 7/18 - Polyols
• C12N 1/20 - BactériesLeurs milieux de culture
• C12R 1/22 - Klebsiella
• C12R 1/145 - Clostridium

Abrégé

The invention relates to a method for producing salts of butyric acid, lactic acid, propionic acid, valeric acid, acetic acid, glycolic acid, sorbic acid, fumaric acid, formic acid, malic acid, tartaric acid, citric acid, derivatives of said organic acids and mixtures thereof, comprising at least the successive steps of: •i) culturing a microorganism in an appropriate culture medium comprising a carbon source and a nitrogen source, during a sufficient time to obtain a fermentation broth comprising the organic acid(s); •ii) pre-treating said fermentation broth comprising at least clarification of the fermentation broth and separation of organic acids by evaporation of the clarified fermentation broth and then condensation of the volatile fraction containing organic acids (CVAF); •v) adding inorganic bases to said CVAF •vii) eliminating the remaining water of the CVAF, and recovering the organic acid salts.

Classes IPC  ?

• C12P 7/54 - Acide acétique
• C12P 7/42 - Acides hydroxycarboxyliques
• C12P 7/52 - Acide propioniqueAcides butyriques
• C12P 7/56 - Acide lactique

Abrégé

The present invention relates to new methylglyoxal reductase (MGR) enzymes which are useful for efficiently converting methylglyoxal into hydroxyacetone. The invention more particularly relates to a method for efficiently converting methylglyoxal into hydroxyacetone using said enzymes, to a method for producing 1,2-propanediol using a microorganism overexpressing said enzymes, and to said microorganism.

Classes IPC  ?

• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12P 7/18 - Polyols
• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 9/88 - Lyases (4.)
• C12P 7/28 - Produits contenant de l'acétone

Produits et services

(1) Produits chimiques à usage industriel, agents biochimiques à usage industriel, produits chimiques pour la science, agents biochimiques pour la science, produits chimiques agricoles, agents biochimiques agricoles, produits chimiques horticoles, agents biochimiques horticoles, produits chimiques pour la sylviculture, agents biochimiques pour la sylviculture nommément produits chimiques de fermentation industrielle et produits chimiques biosourcés, nommément constituants de produits phytosanitaires, des engrais, des produits agrochimiques tels que des fertilisants, produits chimiques organiques de base et produits chimiques d'origine biologique, nommément acides aminés, molécules linéaires, molécules cycliques, molécules aromatiques comprenant au moins une fonction choisie parmi acide carboxylique, anhydride d'acide, ester, halogénure d'acide, amide, nitrile, aldéhyde, cétone, alcool, amine, ether oxyde, alcène, alcane ou organométallique; produits chimiques ou additifs chimiques pour la fabrication de polymères; produits chimiques ou additifs chimiques pour la fabrication de cosmétiques; produits chimiques ou additifs chimiques pour la fabrication de parfums; produits chimiques ou additifs chimiques pour la fabrication d'arômes alimentaires; produits chimiques ou additifs chimiques pour la fabrication de produits alimentaires; résines artificielles à l'état brut; résines polymères à l'état brut; matières plastiques à l'état brut; adhésifs pour utilisation dans l'industrie textile; adhésifs pour utilisation dans le domaine de la biochimie industrielle; composts, engrais, fertilisants; acide butyrique; propanediol. (2) Produits cosmétiques et préparations cosmétiques non médicamenteux, nommément produits de parfumerie, huiles essentielles à usage cosmétique, préparations pour blanchir à usage cosmétique, crème nettoyante à usage cosmétique, préparations dégraissantes pour utilisation sur la peau, abrasifs pour la peau, préparations de toilette non médicamenteuses, nommément dentifrices; huiles essentielles à usage alimentaire; poudre de blanchissage pour la lessive; préparations pour polir les ongles. (3) Préparations médicales, vétérinaires contenant des acides aminés ou des acides organiques à activité prébiotique, probiotique ou postbiotique; suppléments diététiques à base d'acides aminés, d'acides organiques employés chez les animaux d'élevage; compléments alimentaires pour êtres humains, pour animaux enrichis en acides aminés, en acides organiques; produits alimentaires enrichis en acides aminés, en acides organiques à usage médical, à usage vétérinaire; produits pour la destruction d'animaux nuisibles; fongicides, herbicides.

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; composts, manure, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; organic acids for scientific and industrial purposes, namely, butyric acid; glycols for scientific and industrial purposes namely, propanediol Non-medicated cosmetic preparations and cosmetic products, namely, cosmetic masks, cosmetic soaps, lotions for cosmetic purposes; non-medicated toiletry preparations; non-medicated dentifrices; perfumery products, namely, perfume, cologne, fragrances; essential oils; food flavorings being essential oils; bleaching preparations for laundry use and other substances for laundry use, namely, laundry detergents, laundry soap, laundry starch; cleaning, polishing, degreasing for household purposes and abrasive preparations Pharmaceutical products, medical and veterinary preparations for the treatment of metabolic, hormonal, cutaneous, dermatological, endocrine, cardiovascular, pulmonary, ophthalmic, gastrointestinal, infections, viral, genetic, neurological, cancerous, musculoskeletal, hepatological, respiratory, psychiatric and immune system related diseases, disorders and conditions; dietetic food and substances in the nature of preparations and infusions for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use, namely, food supplements; preparations for destroying vermin; fungicides; herbicides

Abrégé

The present invention concerns a new mutant strain of Clostridium acetobutylicum comprising attenuated glycerol kinase activity. In addition, the present invention concerns a consortium of Clostridium comprising at least said mutant strain and at least one other species of Clostridium chosen among C. sporogenes and C. sphenoides.As this modified strain may be adapted for growth and for the production of 1,3-propanediol in an appropriate culture medium with high glycerol content, the invention also relates to a method for the production of 1,3-propanediolandbutyric acid, by culturing at least this mutant strain in an appropriate culture medium.

Classes IPC  ?

• C12P 7/18 - Polyols
• C12P 7/52 - Acide propioniqueAcides butyriques
• C07K 14/33 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Clostridium (G)
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)

Abrégé

The present invention relates to methods and recombinant microorganisms useful for the production of glycolic acid and/or glyoxylic acid. The methods of the invention involve either only one step of fermentation of the modified microorganisms of the invention or one step of fermentation of the modified microorganisms of the invention and one step of either biological or chemical conversion of the glycolic acid or of the glyoxylic acid, the microorganism of the invention over expressing a phosphoketolase gene.

Classes IPC  ?

• C12P 7/42 - Acides hydroxycarboxyliques
• C12N 9/88 - Lyases (4.)
• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12P 7/40 - Préparation de composés organiques contenant de l'oxygène contenant un groupe carboxyle

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use. Pharmaceutical products, medical and veterinary preparations; dietetic food and substances for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use; products for destroying vermin; fungicides, herbicides. Scientific and technological services, research and design services relating thereto; chemical and biochemical laboratory services; scientific research and engineering in the fields of chemistry, biology and biotechnology; chemical analysis; technical, scientific and technological research and development of products, from idea to industrial production, obtained by fermentation of microorganisms for use in the chemical, pharmaceutical, biotechnological industries and in the field of food for human and animal consumption, cosmetics and polymers.

Abrégé

C. sphenoides. The invention also relates to a method for the production of 1,3-propanediol by culturing this microbial consortium resulting in a co-culture of these particular different microorganisms.

Classes IPC  ?

• C12P 7/18 - Polyols
• C12N 1/20 - BactériesLeurs milieux de culture

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical bio-sourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use Pharmaceutical products, medical and veterinary preparations, namely, for treating metabolic, hormonal, cutaneous, dermatological, endocrine, cardiovascular, pulmonary, ophthalmic, gastrointestinal, infectious, viral, genetic, neurological, cancerous, musculoskeletal, hepatological, respiratory, psychiatric and immune system related diseases, disorders and conditions; dietetic food and substances for medical and veterinary use; food supplements for humans and animals; food products in the nature of food supplements, dietetic foods enriched with nutritional elements for medical and veterinary use; products for destroying, namely, in particular vermin destroying preparations; fungicides, herbicides Scientific and technological services, research and design services relating thereto, namely, scientific research; chemical and biochemical laboratory services; scientific research and engineering in the fields of chemistry, biology and biotechnology; chemical analysis; technical, scientific and technological research and development of products, from idea to industrial production, obtained by fermentation of microorganisms for use in the chemical, pharmaceutical, biotechnological industries and in the field of food for human and animal consumption, cosmetics and polymers

Abrégé

The present invention relates to a new method for the production of a molecule of interest by conversion of a source of carbon in a fermentative process comprising culturing a microorganism genetically modified for the production of molecule of interest, wherein said microorganism comprises functional genes coding PTS carbohydrate utilization system and wherein the expression of proteins regulated the expression of phosphoenolpyruvate synthase (PPS) is down-regulated. The present invention also relates to the genetically modified microorganism used in the method of the invention.

Classes IPC  ?

• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12N 1/20 - BactériesLeurs milieux de culture
• C12N 1/16 - LevuresLeurs milieux de culture
• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• C07K 14/245 - Escherichia (G)
• C12P 7/18 - Polyols
• C12P 7/42 - Acides hydroxycarboxyliques
• C12R 1/19 - Escherichia coli
• C12P 7/06 - Éthanol en tant que produit chimique et non en tant que boisson alcoolique
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes

Abrégé

The present invention concerns a genetically modified microorganism for the production of a derivative of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3- propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,4-dihydroxybutyrate, said microorganism further comprising a gene coding for a mutant phosphoserine aminotransferase having an improved L-homoserine aminotransferase activity converting by transamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3-propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,4- dihydroxybutyrate by culturing said genetically modified microorganism in a culture medium and recovering the desired derivative.

Classes IPC  ?

• C12N 9/10 - Transférases (2.)
• C07C 31/20 - Alcools dihydroxyliques
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12P 7/18 - Polyols

Abrégé

The invention relates to a method for producing salts of butyric acid, lactic acid, propionic acid, valeric acid, acetic acid, glycolic acid, sorbic acid, fumaric acid, formic acid, malic acid, tartaric acid, citric acid, derivatives of said organic acids and mixtures thereof, comprising at least the successive steps of: • i) culturing a microorganism in an appropriate culture medium comprising a carbon source and a nitrogen source, during a sufficient time to obtain a fermentation broth comprising the organic acid(s); • ii) pre-treating said fermentation broth comprising at least clarification of the fermentation broth and separation of organic acids by evaporation of the clarified fermentation broth and then condensation of the volatile fraction containing organic acids (CVAF); • v) adding inorganic bases to said CVAF • vii) eliminating the remaining water of the CVAF, and recovering the organic acid salts.

Classes IPC  ?

• C12P 7/40 - Préparation de composés organiques contenant de l'oxygène contenant un groupe carboxyle
• C12P 7/42 - Acides hydroxycarboxyliques
• C12P 7/52 - Acide propioniqueAcides butyriques
• C12P 7/54 - Acide acétique
• C12P 7/56 - Acide lactique

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; butyric acid; propanediol.

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; butyric acid; propanediol. Non-medicated cosmetic preparations and cosmetic products; non-medicated toilet preparations; non-medicated dentifrices; perfumery products and perfumes, essential oils; bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations.

Produits et services

Pharmaceutical products, medical and veterinary preparations; dietetic food and substances for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use; products for destroying vermin; fungicides, herbicides. Food products and beverages for animals.

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; butyric acid; propanediol. Non-medicated cosmetic preparations and cosmetic products; non-medicated toilet preparations; non-medicated dentifrices; perfumery products and perfumes, essential oils; bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations. Pharmaceutical products, medical and veterinary preparations; dietetic food and substances for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use; products for destroying vermin; fungicides, herbicides. Food flavorings, other than essential oils. Food products and beverages for animals.

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; butyric acid; propanediol. Non-medicated cosmetic preparations and cosmetic products; non-medicated toilet preparations; non-medicated dentifrices; perfumery products and perfumes, essential oils; bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations. Pharmaceutical products, medical and veterinary preparations; dietetic food and substances for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use; products for destroying vermin; fungicides, herbicides. Food flavorings, other than essential oils. Food products and beverages for animals.

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; butyric acid; propanediol. Non-medicated cosmetic preparations and cosmetic products; non-medicated toilet preparations; non-medicated dentifrices; perfumery products and perfumes, essential oils; bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations. Pharmaceutical products, medical and veterinary preparations; dietetic food and substances for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use; products for destroying vermin; fungicides, herbicides. Food flavorings, other than essential oils. Food products and beverages for animals.

Produits et services

Non-medicated cosmetic preparations and cosmetic products; non-medicated toilet preparations; non-medicated dentifrices; perfumery products and perfumes, essential oils; bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations. Food flavorings, other than essential oils.

Abrégé

hcpRfrdXhcpRfrdXfrdX gene.

Classes IPC  ?

• C12P 7/18 - Polyols
• C12R 1/145 - Clostridium
• C12N 1/36 - Adaptation ou atténuation de cellules

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; organic acids for scientific and industrial purposes, namely, butyric acid; diols for scientific and industrial purposes, namely, propanediol

Produits et services

Pharmaceutical products, medical and veterinary preparations for treating metabolic, hormonal, cutaneous, dermatological, endocrine, cardiovascular, pulmonary, ophthalmic, gastrointestinal, infectious, viral, genetic, neurological, cancerous, musculoskeletal, hepatological, respiratory, psychiatric and immune system related diseases, disorders and conditions; dietetic food and substances adapted for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use, in particular food supplements; products for destroying vermin, in particular Vermin destroying preparations; fungicides, herbicides * ; all the aforesaid goods not related to sports * Food products and beverages for animals

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; organic acids for scientific and industrial purposes, namely, butyric acid; diols for scientific and industrial purposes, namely, propanediol Non-medicated cosmetic preparations and cosmetic products, namely, cosmetic preparations, chemicals sold as components of cosmetics, plant and herb extracts sold as components of cosmetics, collagen preparations for cosmetic purposes, cosmetics in the form of milks, lotions, emulsions, gels, creams, oils, greases, masks, pomades, body powders, sprays for use on the body, cosmetic hair filling fibers for covering bald and thinning spots on the scalp, and soaps; non-medicated toiletry preparations; non-medicated dentifrices; perfumery products namely, perfumes, essential oils; bleaching preparations and other substances for laundry use, namely, laundry bleaching preparations and laundry starch; cleaning, polishing, degreasing for household purposes, and abrasive preparations Pharmaceutical products, medical and veterinary preparations for treating metabolic, hormonal, cutaneous, dermatological, endocrine, cardiovascular, pulmonary, ophthalmic, gastrointestinal, infectious, viral, genetic, neurological, cancerous, musculoskeletal, hepatological, respiratory, psychiatric and immune system related diseases, disorders and conditions; dietetic food and substances adapted for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use, in particular food supplements; products for destroying vermin, in particular Vermin destroying preparations; fungicides, herbicides * ; all the aforesaid goods not related to sports nutrition * Food flavorings, other than essential oils * ; all the aforesaid goods not related to sports nutrition * Food products and beverages for animals

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; organic acids for scientific and industrial purposes, namely, butyric acid; diols for scientific and industrial purposes, namely, propanediol Non-medicated cosmetic preparations and cosmetic products, namely, cosmetic preparations, chemicals sold as components of cosmetics, plant and herb extracts sold as components of cosmetics, collagen preparations for cosmetic purposes, cosmetics in the form of milks, lotions, emulsions, gels, creams, oils, greases, masks, pomades, body powders, sprays for use on the body, cosmetic hair filling fibers for covering bald and thinning spots on the scalp, and soaps; non-medicated toiletry preparations; non-medicated dentifrices; perfumery products namely, perfumes, essential oils; bleaching preparations and other substances for laundry use, namely, laundry bleaching preparations and laundry starch; cleaning, polishing, degreasing for household purposes, and abrasive preparations Pharmaceutical products, medical and veterinary preparations for treating metabolic, hormonal, cutaneous, dermatological, endocrine, cardiovascular, pulmonary, ophthalmic, gastrointestinal, infectious, viral, genetic, neurological, cancerous, musculoskeletal, hepatological, respiratory, psychiatric and immune system related diseases, disorders and conditions; dietetic food and substances adapted for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use, in particular food supplements; products for destroying vermin, in particular Vermin destroying preparations; fungicides, herbicides* ; all the aforesaid goods not related to sports nutrition * Food flavorings, other than essential oils * ; all the aforesaid goods not related to sports nutrition * Food products and beverages for animals

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; organic acids for scientific and industrial purposes, namely, butyric acid; diols for scientific and industrial purposes, namely, propanediol Non-medicated cosmetic preparations and cosmetic products, namely cosmetic preparations, chemicals sold as components of cosmetics, plant and herb extracts sold as components of cosmetics, collagen preparations for cosmetic purposes, cosmetics in the form of milks, lotions, emulsions, gels, creams, oils, greases, masks, pomades, body powders, sprays for use on the body, cosmetic hair filling fibers for covering bald and thinning spots on the scalp and soaps; non-medicated toiletry preparations; non-medicated dentifrices; perfumery products namely, perfumes, essential oils; bleaching preparations and other substances for laundry use, namely laundry bleaching preparations and laundry starch; cleaning, polishing, degreasing for household purposes, and abrasive preparations

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; compost, manures, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; organic acids for scientific and industrial purposes, namely, butyric acid; diols for scientific and industrial purposes, namely, propanediol Non-medicated cosmetic preparations and cosmetic products, namely, cosmetic preparations, chemicals sold as components of cosmetics, plant and herb extracts sold as components of cosmetics, collagen preparations for cosmetic purposes, cosmetics in the form of milks, lotions, emulsions, gels, creams, oils, greases, masks, pomades, body powders, sprays for use on the body, cosmetic hair filling fibers for covering bald and thinning spots on the scalp and soaps; non-medicated toiletry preparations; non-medicated dentifrices; perfumery products, namely, perfumes, essential oils; bleaching preparations and other substances for laundry use, namely, laundry bleaching preparations and laundry starch; cleaning, polishing, degreasing for household purposes, and abrasive preparations Pharmaceutical products, medical and veterinary preparations for treating metabolic, hormonal, cutaneous, dermatological, endocrine, cardiovascular, pulmonary, ophthalmic, gastrointestinal, infectious, viral, genetic, neurological, cancerous, musculoskeletal, hepatological, respiratory, psychiatric and immune system related diseases, disorders and conditions; dietetic food and substances adapted for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use, in particular food supplements; products for destroying vermin, in particular Vermin destroying preparations; fungicides, herbicides * ; all the aforesaid goods not related to sports nutrition * Food flavorings, other than essential oils * ; all the aforesaid goods not related to sports nutrition * Food products and beverages for animals

Produits et services

Non-medicated cosmetic preparations and cosmetic products, namely cosmetic preparations, chemicals sold as components of cosmetics, plant and herb extracts sold as components of cosmetics, collagen preparations for cosmetic purposes, cosmetics in the form of milks, lotions, emulsions, gels, creams, oils, greases, masks, pomades, body powders, sprays for use on the body, cosmetic hair filling fibers for covering bald and thinning spots on the scalp and soaps; non-medicated toiletry preparations; non-medicated dentifrices; perfumery products namely, perfumes, essential oils; bleaching preparations and other substances for laundry use, namely laundry bleaching preparations and laundry starch; cleaning, polishing, degreasing for household purposes, and abrasive preparations Food flavorings, other than essential oils * ; all the aforesaid goods not related to sports nutrition *

Produits et services

(1) Produits chimiques à usage industriel, agents biochimiques à usage industriel, produits chimiques pour la science, agents biochimiques pour la science, à savoir produits chimiques agricoles, agents biochimiques agricoles, produits chimiques horticoles, agents biochimiques horticoles, produits chimiques pour la sylviculture, agents biochimiques pour la sylviculture nommément produits chimiques de fermentation industrielle et produits chimiques biosourcés, nommément constituants de produits phytosanitaires, des engrais, des produits agrochimiques à savoir des fertilisants, produits chimiques organiques de base et produits chimiques d'origine biologique, nommément acides aminés, molécules linéaires, cycliques, aromatiques comprenant au moins une fonction choisie parmi acide carboxylique, anhydride d'acide, ester, halogénure d'acide, amide, nitrile, aldéhyde, cétone, alcool, amine, ether oxyde, alcène, alcane, organométallique; produits chimiques pour la fabrication de polymères, additifs chimiques pour la fabrication de polymères; produits chimiques pour la fabrication de cosmétiques, additifs chimiques pour la fabrication de cosmétiques; produits chimiques pour la fabrication de parfums, additifs chimiques pour la fabrication de parfums; produits chimiques pour la fabrication d'arômes alimentaires, additifs chimiques pour la fabrication d'arômes alimentaires; produits chimiques pour la fabrication de produits alimentaires, additifs chimiques pour la fabrication de produits alimentaires; résines artificielles à l'état brut; résines polymères à l'état brut; matières plastiques à l'état brut; adhésifs pour utilisation dans l'industrie textile; adhésifs à usage général dans le domaine de la biochimie industrielle; composts, engrais, fertilisants ; acide butyrique; propanediol. (2) Produits cosmétiques et préparations cosmétiques non médicamenteux, nommément : produits de parfumerie et parfums, huiles essentielles à usage cosmétique, préparations pour blanchir à usage cosmétique, poudre de blanchissage pour la lessive, crème nettoyante à usage cosmétique, préparations pour polir les ongles, préparations dégraissantes pour utilisation sur la peau, abrasifs pour la peau; préparations de toilette non médicamenteuses, nommément dentifrices non médicamenteux; arômes alimentaires en tant qu'huiles essentielles. (3) Préparation médicales et vétérinaires à activité prébiotique, probiotique, postbiotique contenant des acides aminés, des acides organiques; supplément diététique à base d'acides aminés, d'acides organiques employés chez les animaux d'élevage; compléments alimentaires pour êtres humains ou animaux enrichis en acides aminés, acides organiques; produits alimentaires enrichis en acides aminés, en acides organiques à usage médical, vétérinaire; produits pour la destruction d'animaux nuisibles; fongicides, herbicides; tous les produits précités étant non liés à la nutrition sportive. (4) Additifs issus de fermentation composés d'acides aminés, d'acides organiques utilisés comme arômes alimentaires; tous les produits précités étant non liés à la nutrition sportive. (5) Aliments pour animaux, boissons pour animaux de compagnie.

Produits et services

Chemical products and additives for use in industry, science as well as agriculture, horticulture and forestry particularly basic organic chemicals, chemical products for industrial fermentation, chemical products of biological origin, chemical biosourced products excluding fungicides, herbicides, insecticides and parasiticides; chemical products and additives other than for medical or veterinary use for the manufacture of polymers, cosmetics, perfumes, food flavorings, foodstuffs; unprocessed artificial resins; unprocessed polymer resins; unprocessed plastics; adhesives for use in industry; composts, manure, fertilizers; biological preparations for industrial and scientific use other than for medical or veterinary use; butyric acid; propanediol. Non-medicated cosmetic preparations and cosmetic products; non-medicated toilet preparations; non-medicated dentifrices; perfumery products, essential oils; food flavorings [essential oils]; bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations. Pharmaceutical products, medical and veterinary preparations; dietetic food and substances for medical or veterinary use; food supplements for humans and animals; food products enriched with nutritional elements for medical or veterinary use; products for destroying vermin; fungicides, herbicides. Food products and beverages for animals.

Abrégé

The present invention relates to a genetically modified microorganism for the fermentative conversion of levulinic acid into propionyl-CoA and acetyl-CoA, and to a fermentation process for performing said conversion.

Classes IPC  ?

• C12P 17/18 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, p. ex. rifamycine
• C12P 7/04 - Préparation de composés organiques contenant de l'oxygène contenant un groupe hydroxyle acycliques
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 9/10 - Transférases (2.)
• C12P 7/06 - Éthanol en tant que produit chimique et non en tant que boisson alcoolique
• C12P 7/42 - Acides hydroxycarboxyliques
• C12P 7/18 - Polyols
• C12P 7/16 - Butanols
• C12P 7/46 - Acides dicarboxyliques ayant au plus quatre atomes de carbone, p. ex. acide fumarique, acide maléique
• C12P 13/08 - LysineAcide diaminopiméliqueThréonineValine
• C12P 13/12 - MéthionineCystéineCystine
• C12N 1/16 - LevuresLeurs milieux de culture
• C12N 1/20 - BactériesLeurs milieux de culture
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
• C12N 15/81 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour champignons pour levures

Abrégé

The present invention relates to new lactaldehyde reductase (LAR) enzymes useful for the production of 1,2-propanediol and to microorganisms overexpressing said enzymes. The invention also relates to a method for producing 1,2-propanediol by converting lactaldehyde into 1,2-propanediol with said enzymes.

Classes IPC  ?

• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12P 7/18 - Polyols
• C12R 1/19 - Escherichia coli

Abrégé

The present invention relates to a microbial consortium, especially adapted for growth and production of 1,3-propanediol from a culture medium with high glycerinecontent and specifically with a high concentration of industrial glycerine. More particularly, this microbial consortium comprises at least one strain C. acetobutylicum and at least one strain chosen among strains of C. sporogenes and/or strains of C. sphenoides. The invention also relates to a method for the production of 1,3-propanediol by culturing this microbial consortium resulting in a co-culture of these particular different microorganisms.

Classes IPC  ?

• C12P 7/18 - Polyols
• C12N 1/20 - BactériesLeurs milieux de culture

Abrégé

The present invention relates to methods and recombinant microorganisms useful for the production of glycolic acid and/or glyoxylic acid. The methods of the invention involve either only one step of fermentation of the modified microorganisms of the invention or one step of fermentation of the modified microorganisms of the invention and one step of either biological or chemical conversion of the glycolic acid or of the glyoxylic acid, the microorganism of the invention over expressing a phosphoketolase gene.

Classes IPC  ?

• C12P 7/24 - Préparation de composés organiques contenant de l'oxygène contenant un groupe carbonyle
• C12P 7/42 - Acides hydroxycarboxyliques
• C12N 9/88 - Lyases (4.)

Abrégé

The present invention relates to new methylglyoxal reductase (MGR) enzymes which are useful for efficiently converting methylglyoxal into hydroxyacetone. The invention more particularly relates to a method for efficiently converting methylglyoxal into hydroxyacetone using said enzymes, to a method for producing 1,2-propanediol using a microorganism overexpressing said enzymes, and to said microorganism.

Classes IPC  ?

• C12P 7/18 - Polyols
• C12P 7/26 - Cétones

Abrégé

The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized production of 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.

Classes IPC  ?

• C12P 7/42 - Acides hydroxycarboxyliques
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C07K 14/245 - Escherichia (G)
• C07K 14/39 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de champignons provenant de levures
• C07K 14/395 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de champignons provenant de levures provenant de Saccharomyces
• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 9/18 - Hydrolases agissant sur les esters d'acides carboxyliques

Abrégé

The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via the 1,2,4-butanetriol intermediate. The invention also relates to a method for the production of 2,4-dihydroxybutyrate by culturing said genetically modified microorganism in a fermentation medium and recovering 2,4-DHB from said medium.

Classes IPC  ?

• C12P 7/42 - Acides hydroxycarboxyliques
• C07C 31/22 - Alcools trihydroxyliques, p. ex. glycérol
• C07C 47/19 - Composés saturés comportant des groupes —CHO liés à des atomes de carbone acycliques ou à de l'hydrogène contenant des groupes hydroxyle
• C07C 59/10 - Acides polyhydroxycarboxyliques
• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12P 7/18 - Polyols
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci
• C12N 1/00 - Micro-organismes, p. ex. protozoairesCompositions les contenantProcédés de culture ou de conservation de micro-organismes, ou de compositions les contenantProcédés de préparation ou d'isolement d'une composition contenant un micro-organismeLeurs milieux de culture
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C12R 1/19 - Escherichia coli
• C12R 1/07 - Bacillus
• C12R 1/145 - Clostridium

Abrégé

The present invention relates to a new method for the production of a molecule of interest by conversion of a source of carbon in a fermentative process comprising culturing a microorganism genetically modified for the production of molecule of interest, wherein said microorganism comprises functional genes coding PTS carbohydrate utilization system and wherein the expression of proteins regulated the expression of phosphoenolpyruvate synthase (PPS) is down -regulated. The present invention also relates to the genetically modified microorganism used in the method of the invention.

Classes IPC  ?

• C07K 14/245 - Escherichia (G)
• C12P 7/00 - Préparation de composés organiques contenant de l'oxygène
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12R 1/00 - Micro-organismes

Produits et services

Scientific and technological research, research and design services relating thereto; chemical and biochemical laboratory services; scientific research and engineering in the fields of chemistry, biology and biotechnology; chemical analysis; technical, scientific and technological research and development services for new products obtained by fermentation of microorganisms intended for the chemical, pharmaceutical, biotechnological industries and the field of food for humans and animals, cosmetics and polymers, none of the above-mentioned services related to software for the development and planning of assembly systems for photovoltaic installations.

Produits et services

Scientific and technological services, research and design services relating thereto; chemical and biochemical laboratory services; scientific research and engineering in the fields of chemistry, biology and biotechnology; chemical analysis; technical, scientific and technological research and development services regarding new products obtained by fermentation of microorganisms for use in the chemical, pharmaceutical, biotechnological industries and in the field of food for human and animal consumption, cosmetics and polymers.

Abrégé

The present invention concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate chosen among 1,3-propanediol or 2,4-dihydroxybutyrate by culturing a genetically modified microorganism for the production of the desired derivative of 4-hydroxy-2-ketobutyrate, the microorganism further comprising a gene coding for a mutant glutamate dehydrogenase converting by deamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns said genetically modified microorganism.

Classes IPC  ?

• C12N 1/20 - BactériesLeurs milieux de culture
• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• C12P 7/18 - Polyols
• C12P 7/42 - Acides hydroxycarboxyliques

Abrégé

The present invention relates to a recombinant microorganism useful for the production of 1,2-propanediol and process for the preparation of 1,2-propanediol. The microorganism of the invention is modified in a way that the 1,2-propanediol production is improved by enhancing NADPH dependent HAR activity.

Classes IPC  ?

• C12P 7/18 - Polyols
• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora

Abrégé

The present invention relates to a genetically modified microorganism for the fermentative conversion of levulinic acid into propionyl-CoA and acetyl-CoA, and to a fermentation process for performing said conversion.

Classes IPC  ?

• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 9/10 - Transférases (2.)
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12P 7/52 - Acide propioniqueAcides butyriques

Abrégé

The present invention relates to new lactaldehyde reductase (LAR) enzymes useful for the production of 1,2-propanediol and to microorganisms overexpressing said enzymes. The invention also relates to a method for producing 1,2-propanediol by converting lactaldehyde into 1,2-propanediol with said enzymes.

Classes IPC  ?

• C12P 7/18 - Polyols
• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)

Produits et services

Soil fertilizers; bacterial preparations other than for medical and veterinary use; agricultural chemicals except fungicides, herbicides, insecticides and parasiticides; cultures of microorganisms other than for medical and veterinary use; nitrogen fertilizer; fertilizers for agriculture; fertilizing products; preparations of microorganisms other than for medical or veterinary use; vitamins for the manufacture of food supplements; proteins for the manufacture of food supplements. Dietetic substances and foodstuffs for veterinary use; food supplements as normal diet supplements or as contributions for health; anti-parasitic products; bacteriological preparations for veterinary use; nutritional supplements; food supplements for animals; protein dietary supplements; protein supplements for animals. Foodstuffs for animals; strengthening animal forage; strengthening fodder; food products for animals; animal fattening products; foodstuffs for animals containing in particular micro-organisms.

Abrégé

The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized productionof 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.

Classes IPC  ?

• C12N 1/00 - Micro-organismes, p. ex. protozoairesCompositions les contenantProcédés de culture ou de conservation de micro-organismes, ou de compositions les contenantProcédés de préparation ou d'isolement d'une composition contenant un micro-organismeLeurs milieux de culture
• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12P 7/16 - Butanols
• C12P 7/42 - Acides hydroxycarboxyliques

Abrégé

The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via the 1,2,4- butanetriol intermediate. The invention also relates to a method for the production of 2,4- dihydroxybutyrate by culturing said genetically modified microorganism in a fermentation medium and recovering 2,4-DHB from said medium.

Classes IPC  ?

• C07C 59/10 - Acides polyhydroxycarboxyliques
• C12P 7/42 - Acides hydroxycarboxyliques

Produits et services

(1) Engrais pour les terres; engrais azoté; engrais pour l'agriculture; fertilisants; préparations de micro-organismes pour la fabrication et la conservation d'aliments pour animaux, à utiliser comme additifs alimentaires; vitamines pour la fabrication de compléments alimentaires; protéines pour la fabrication de compléments alimentaires (2) Aliments diététiques pour animaux; produits antiparasitaires; préparations bactériologiques pour contribuer à l'équilibre de la flore intestinale et au maintien général d'une bonne santé des animaux; compléments alimentaires pour animaux; compléments de protéine pour animaux (3) Aliments pour animaux; substances alimentaires fortifiantes pour animaux; fourrages fortifiants; aliments pour animaux contenant notamment des micro-organismes

Produits et services

(1) Aliments diététiques pour animaux; produits vétérinaires, nommément produits antiparasitaires et des préparations bactériologiques pour animaux; compléments alimentaires pour animaux; préparations de vitamines à usage vétérinaire.. (2) Aliments pour animaux ; substances alimentaires fortifiantes pour animaux ; fourrages fortifiants ; aliments pour animaux contenant notamment des microorganismes

Abrégé

The present invention concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate chosen among 1,3-propanediol or 2,4-dihydroxybutyrate by culturing a genetically modified microorganism for the production of the desired derivative of 4-hydroxy-2-ketobutyrate, the microorganism further comprising a gene coding for a mutant glutamate dehydrogenase converting by deamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns said genetically modified microorganism.

Classes IPC  ?

• C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
• C12P 7/18 - Polyols
• C12P 7/42 - Acides hydroxycarboxyliques
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 15/53 - Oxydoréductases (1)

Abrégé

The present invention is related to a recombinant microorganism optimised for the fermentative production of methionine and/or its derivatives, wherein in said recombinant strain, the methionine efflux is enhanced by overexpressing the homologous genes of ygaZ and ygaH genes from Escherichia coli. It is also related to a method for optimising the fermentative production of methionine or its derivatives comprising the steps of: a. culturing a recombinant microorganism wherein in said microorganism, the methionine efflux is enhanced by overexpressing the ygaZH homologous genes of ygaZ and ygaH genes from Escherichia coli, in an appropriate culture medium comprising a fermentable source of carbon and a source of sulphur, and b. recovering methionine and/or its derivatives from the culture medium.

Classes IPC  ?

• C12P 13/12 - MéthionineCystéineCystine
• C07K 14/24 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant d'Entérobacteriaceae (F), p. ex. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
• C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli

Abrégé

The present invention relates to a recombinant microorganism useful for the production of 1,2-propanediol and process for the preparation of 1,2-propanediol. The microorganism of the invention is modified in a way that the 1,2-propanediol production is improved by enhancing NADPH dependent HAR activity.

Classes IPC  ?

• C12P 7/18 - Polyols

Abrégé

The present invention is relative to a method for producing 1,2-propanediol by fermentation, comprising: cultivating a microorganism producing 1,2-propanediol in an appropriate medium comprising a source of sucrose, and recovering the 1,2-propanediol being produced, wherein the microorganism is able to utilize sucrose as sole carbon source for the production of 1,2-propanediol. In a preferred aspect of the invention, the source of sucrose is obtained from plant biomass, and is in particular sugar cane juice.

Classes IPC  ?

• C12P 7/18 - Polyols

Abrégé

The present application is related to a recombinant microorganism optimised for the fermentative production of methionine and/or its derivatives, wherein in said recombinant microorganism, the cobalamin-dependent methionine synthase activity and the methionine efflux are enhanced. The application is also related to a method for optimizing the fermentative production of methionine and/or its derivatives comprising the steps of: c. culturing a recombinant microorganism wherein in said microorganism, the cobalamin-dependent methionine synthase activity and the methionine efflux are enhanced, in an appropriate culture medium comprising a fermentable source of carbon and a source of sulphur, and d. recovering methionine and/or its derivatives from the culture medium.

Classes IPC  ?

• C12P 13/12 - MéthionineCystéineCystine
• C12N 9/10 - Transférases (2.)

Abrégé

The present invention is related to arecombinant Escherichia coli(E. coli) strain optimised for the fermentative production of methionine and/or its derivatives, wherein in said recombinant strain, the methionine import is attenuated and the methionine efflux is enhanced. It is also related to a method for optimising the fermentative production of methionine or its derivatives comprising the steps of: a. culturing a recombinant microorganism wherein in said microorganism, the methionine import is attenuated and the methionine efflux is enhanced,in an appropriate culture medium comprising a fermentable source of carbon and a source of sulphur, and b. recovering methionine and/or its derivatives from the culture medium.

Classes IPC  ?

• C12N 1/00 - Micro-organismes, p. ex. protozoairesCompositions les contenantProcédés de culture ou de conservation de micro-organismes, ou de compositions les contenantProcédés de préparation ou d'isolement d'une composition contenant un micro-organismeLeurs milieux de culture
• C12N 1/36 - Adaptation ou atténuation de cellules

Abrégé

The present invention concerns a method for the biological preparation of prenol comprising culturing a microorganism genetically modified for the bioproduction of prenol, wherein the microorganism comprises a metabolic pathway for conversion of 3-methylcrotonyl-CoA into prenol by the action of an alcohol dehydrogenase enzyme and of an aldehyde dehydrogenase enzyme.

Classes IPC  ?

• C12P 7/16 - Butanols
• C12P 7/04 - Préparation de composés organiques contenant de l'oxygène contenant un groupe hydroxyle acycliques

Abrégé

The invention relates to a method for the fermentative production of neopentyl glycol comprising culturing a recombinant microorganism in an appropriate culture medium comprising a source of carbon, wherein in said microorganism, the neopentyl glycol biosynthesis pathway comprises 2-dehydropantoate as intermediate product that is converted into neopentyl glycol by two or three successive steps including a decarboxylation and an aldehyde reduction.

Classes IPC  ?

• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes

Abrégé

The invention relates to a method for the fermentative production of ethylenediamine comprising culturing a microorganism in an appropriate culture medium comprising a simple source of carbon and of nitrogen, wherein the microorganism comprises a metabolic pathway for conversion of serine into ethylenediamine.

Classes IPC  ?

• C12P 13/00 - Préparation de composés organiques contenant de l'azote
• C12N 9/10 - Transférases (2.)
• C12N 9/88 - Lyases (4.)
• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 9/80 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5) agissant sur les liaisons amides des amides aliphatiques

Abrégé

The present invention is related to a recombinant microorganism optimised for the fermentative production of methionine, wherein the activity of the cobalamin-independent methionine synthase MetE is attenuated in said microorganism. The invention is also related to a method for producing methionine by fermentation.

Classes IPC  ?

• C12N 9/10 - Transférases (2.)
• C12P 13/12 - MéthionineCystéineCystine

Abrégé

genes enabling the microorganism to utilize sucrose as sole carbon source. A method for the biological preparation of 1,3-propanediol by fermentation, including cultivating said microorganism genetically modified, wherein the culture is performed in an appropriate medium including a source of sucrose, and recovering the 1,3-propanediol being produced.

Classes IPC  ?

• C12P 7/18 - Polyols
• C12N 1/21 - BactériesLeurs milieux de culture modifiés par l'introduction de matériel génétique étranger
• C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
• C12N 9/10 - Transférases (2.)
• C12N 9/88 - Lyases (4.)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12N 1/20 - BactériesLeurs milieux de culture

Abrégé

This invention comprises a process for the bioconversion of a fermentable carbon source to n-butanol by a microorganism, wherein the microorganism is deficient in at least one gene or protein involved in the four-carbon compounds pathway regulation to improve the four- carbon compounds pathway, particularly by inactivation of the transcriptional repressor rex.

Classes IPC  ?

• C12N 15/74 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome
• C12P 7/16 - Butanols

Abrégé

The present invention is related to a recombinant microorganism engineered for the production of 2,3-butanediol (BDO), wherein said microorganism overexpresses at least one gene encoding a polypeptide involved in the conversion of pyruvate into 2,3- butanediol. The invention is also related to a method of production of 2,3-butanediol comprising the following steps: - providing a recombinant microorganism as described above, - cultivating the recombinant microorganism in a culture medium containing a source of carbon, and - recovering the 2,3-butanediol.

Classes IPC  ?

• C12P 7/16 - Butanols