Abrégé

Disclosures herein relate to methods of producing oral powdered compositions for fecal microbiota transplant and related methods of treatment. Procedures for producing the powdered composition may include filtering a fecal sample with a filter medium to generate a filtrate, separating particulate matter of the filtrate to obtain a first sediment and a first supernatant, repeatedly resuspending the first sediment and separating particulate matter of the resuspended first sediment to obtain a second sediment and a second supernatant, diluting the second supernatant and repeatedly separating particulate matter out of the second supernatant to obtain a third sediment and a third supernatant, resuspending the third sediment in a cryoprotectant to obtain a mixture, and freeze-drying the mixture to obtain a freeze-dried, powdered composition, wherein the powdered composition may be substantially tasteless, odorless, and colorless.

Classes IPC  ?

• A61K 35/24 - MucusGlandes des muqueusesBoursesLiquide synovialLiquide articulaireExcretaLiquide céphalorachidien
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées

Abrégé

Disclosures herein relate to methods of producing oral powdered compositions for fecal microbiota transplant including desired microbes and related methods of treatment. Procedures for producing the powdered composition may include filtering a fecal sample, separating particulate matter of the filtrate, repeatedly resuspending the sediment and separating particulate matter, diluting the supernatant and repeatedly separating particulate matter out of the supernatant, resuspending the sediment in a cryoprotectant to obtain a mixture, and freeze-drying the mixture to obtain a freeze-dried, powdered composition, wherein the powdered composition may be substantially tasteless, odorless, and colorless. The FMT composition has an odor as evaluated with a confidence of 95% to be odorless for more than 50% of the population using a triangular test and a flavor as evaluated with a confidence of 80% to be flavorless for more than 50% of the population using the triangular test.

Classes IPC  ?

• A61K 35/74 - Bactéries
• A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
• A61K 35/38 - EstomacIntestinCellules caliciformesMuqueuse oraleSalive
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• A61P 31/04 - Agents antibactériens
• C12N 1/04 - Conservation des micro-organismes à l'état viable
• C12N 1/20 - BactériesLeurs milieux de culture

Abrégé

Disclosures herein relate to methods of producing oral powdered compositions for fecal microbiota transplant and related methods of treatment. Procedures for producing the powdered composition may include filtering a fecal sample with a filter medium to generate a filtrate, separating particulate matter of the filtrate to obtain a first sediment and a first supernatant, repeatedly resuspending the first sediment and separating particulate matter of the resuspended first sediment to obtain a second sediment and a second supernatant, diluting the second supernatant and repeatedly separating particulate matter out of the second supernatant to obtain a third sediment and a third supernatant, resuspending the third sediment in a cryoprotectant to obtain a mixture, and freeze-drying the mixture to obtain a freeze-dried, powdered composition, wherein the powdered composition may be substantially tasteless, odorless, and colorless.

Classes IPC  ?

• A61K 35/24 - MucusGlandes des muqueusesBoursesLiquide synovialLiquide articulaireExcretaLiquide céphalorachidien
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées

Abrégé

Disclosures herein relate to a fecal microbiota transplant (FMT) composition for oral delivery, the FMT composition comprising an FMT including desired fecal microbes, wherein the FMT has an odor as evaluated with a confidence of 95% to be odorless for more than 50% of the population using a triangular test, wherein the FMT has a flavor as evaluated with a confidence of 80% to be flavorless for more than 50% of the population using the triangular test.

Classes IPC  ?

• A61K 35/24 - MucusGlandes des muqueusesBoursesLiquide synovialLiquide articulaireExcretaLiquide céphalorachidien
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

Disclosures herein relate to a fecal microbiota transplant (FMT) composition for oral delivery, the FMT composition comprising an FMT including desired fecal microbes, wherein the FMT has an odor as evaluated with a confidence of 95% to be odorless for more than 50% of the population using a triangular test, wherein the FMT has a flavor as evaluated with a confidence of 80% to be flavorless for more than 50% of the population using the triangular test.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 35/24 - MucusGlandes des muqueusesBoursesLiquide synovialLiquide articulaireExcretaLiquide céphalorachidien
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées