Abrégé

The present disclosure relates to the new method of producing of the stable selenium-comprising pharmaceutical compositions with a high selenium level based on the mixing of nitric acid with therapeutically effective amounts of at least two active ingredients selected from the groups consisting of 2,2-dichlorocarboxylic acids, selenium-containing compound. As a selenium-containing compound the aqueous solution of selenious acid in the amount of no more than 20%, preferably 0.5-10.0%, is used. The group of 2,2-dichlorocarboxylic acids consists 2,2-dichloropropionic acid and their homologes The chemical process is carried out by adding of the concentrated nitric acid in amount of 1.0-5.0% into 2,2-dichlorocarboxylic acid purity of at least 98.5% and completing the redox-interaction under the isothermal conditions at a temperature not higher than 70° C., preferably at 20-30° C., and then an aqueous solution of the selenious acid in an amount of not more than 20.0% (and the other components if it is necessary) is added to form the result pharmaceutical product solution. The product can also contain additional 5-20% of dimethylsulfoxide. The claimed pharmaceutical product is useful for the treating of benign, viral, premalignant, and malignant non-metastasizing skin lesions, of dysplastic lesions of visible mucous coats, fungous and other skin diseases.

Classes IPC  ?

• A01N 59/02 - SoufreSéléniumTellureLeurs composés
• A61K 33/04 - Soufre, sélénium ou tellureLeurs composés
• A61K 31/19 - Acides carboxyliques, p. ex. acide valproïque
• A61K 31/194 - Acides carboxyliques, p. ex. acide valproïque ayant plusieurs groupes carboxyle, p. ex. acides succinique, maléique ou phtalique
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/08 - Solutions

Abrégé

−, where R=alkyl, H or Cl, x=1-2 and n=0-4, in a corresponding alpha-chlorocarboxylic acid, wherein the content of zinc in the solution is 0.25-10.0% and the content of acid is 10-90%. The preparation may additionally contain an additive perfume, for example an ethyl ester of the corresponding alpha-chlorocarboxylic acid. The treatment method consists in that 2-5 doses of the preparation, which has been precooled to 10-15° C., are applied to the affected skin portion with a delay of 1-3 mins between the first and subsequent applications of the preparation. The preparations are stable on storage.

Classes IPC  ?

• C07C 53/19 - Acides contenant au moins trois atomes de carbone
• A61K 31/315 - Composés du zinc
• C07C 53/16 - Acides acétiques halogénés
• C07F 3/06 - Composés du zinc