Abrégé

Disclosed herein are iron-chelating polymers for treatment of diseases with an iron-mediated pathology, said polymers comprising a reaction product of a first monomer unit and a second monomer units polymerized by a reversible addition-fragmentation chain transfer mechanism with the use of a suitable addition-fragmentation chain transfer agent, wherein: the first monomer unit is represented by Compound (I); Disclosed herein are iron-chelating polymers for treatment of diseases with an iron-mediated pathology, said polymers comprising a reaction product of a first monomer unit and a second monomer units polymerized by a reversible addition-fragmentation chain transfer mechanism with the use of a suitable addition-fragmentation chain transfer agent, wherein: the first monomer unit is represented by Compound (I); Disclosed herein are iron-chelating polymers for treatment of diseases with an iron-mediated pathology, said polymers comprising a reaction product of a first monomer unit and a second monomer units polymerized by a reversible addition-fragmentation chain transfer mechanism with the use of a suitable addition-fragmentation chain transfer agent, wherein: the first monomer unit is represented by Compound (I); wherein the second monomer unit is independently selected from the group consisting of 1-vinyl-2-pyrrolidone, acrylic acid, methyl methacrylate, N,N-dimethyl-acrylamide, ethyl methacrylate, N-vinyl imidazole and styrene; the iron-chelating polymer is dissolved in an aqueous medium; the iron-chelating polymer has a molecular weight prior to chelation of at least about 1500 Da; and the iron-chelating polymer comprises one or more intramolecular hexadentate ligands for chelating iron. The described polymers are useful in the treatment of diseases associates with excess reactive iron.

Classes IPC  ?

• A61K 31/79 - Polymères de vinylpyrrolidone
• A61K 31/4422 - 1,4-Dihydropyridines, p. ex. nifédipine, nicardipine
• A61P 39/04 - Agents chélateurs

Abrégé

Disclosed are compositions comprising a chelating polymer comprising a first monomer unit and a second monomer unit polymerized via a reversible addition-fragmentation chain transfer mechanism with an addition-fragmentation chain transfer agent, and an anti-infective agent. The composition can be used for treating bacterial infections or for attenuating resistance of a bacteria to the anti-infective agent in a subject.

Classes IPC  ?

• A61K 31/787 - Polymères contenant de l'azote contenant des hétérocycles ayant l'azote comme hétéro-atome d'un cycle
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61P 31/04 - Agents antibactériens
• C07D 213/69 - Au moins deux atomes d'oxygène
• C07D 215/56 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 3 avec des atomes d'oxygène en position 4
• C07D 471/04 - Systèmes condensés en ortho
• C08F 220/54 - Amides
• C08F 226/10 - N-Vinylpyrrolidone

Abrégé

Disclosed herein are iron-chelating polymers for treatment of diseases with an iron-mediated pathology, said polymers comprising a reaction product of a first monomer unit and a second monomer units polymerized by a reversible addition-fragmentation chain transfer mechanism with the use of a suitable addition-fragmentation chain transfer agent, wherein: the first monomer unit is represented by Compound (I); wherein the second monomer unit is independently selected from the group consisting of 1- vinyl-2-pyrrolidone, acrylic acid, methyl methacrylate, N,N-dimethyl-acrylamide, ethyl methacrylate, N-vinyl imidazole and styrene; the iron-chelating polymer is dissolved in an aqueous medium; the iron-chelating polymer has a molecular weight prior to chelation of at least about 1500 Da; and the iron-chelating polymer comprises one or more intramolecular hexadentate ligands for chelating iron. The described polymers are useful in the treatment of diseases associates with excess reactive iron.

Classes IPC  ?

• A61K 31/79 - Polymères de vinylpyrrolidone
• A61P 39/04 - Agents chélateurs
• C08F 220/54 - Amides
• C08F 220/60 - Amides contenant de l'azote en plus de l'azote de la fonction carbonamide
• C08F 226/10 - N-Vinylpyrrolidone

Classes IPC  ?

• A61K 31/79 - Polymères de vinylpyrrolidone
• A61P 39/04 - Agents chélateurs
• C08F 220/54 - Amides
• C08F 220/60 - Amides contenant de l'azote en plus de l'azote de la fonction carbonamide
• C08F 226/10 - N-Vinylpyrrolidone

Classes IPC  ?

• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/787 - Polymères contenant de l'azote contenant des hétérocycles ayant l'azote comme hétéro-atome d'un cycle
• A61P 31/04 - Agents antibactériens
• C07D 213/69 - Au moins deux atomes d'oxygène
• C07D 215/56 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 3 avec des atomes d'oxygène en position 4
• C07D 471/04 - Systèmes condensés en ortho
• C08F 220/54 - Amides
• C08F 226/10 - N-Vinylpyrrolidone