An aerosol generation and delivery system and method for generating a respirable aerosol from a liquid solution or liquid suspension. A liquid solution or liquid suspension is supplied at a liquid pressure, and a pressurized aerosolizing gas is supplied at a pressurized aerosolizing gas pressure to an aerosol generating nozzle having an aerosol exit orifice through which the liquid solution or liquid suspension is released into an aerosolizing space. Controlling the pressure of an aerosolizing gas by a controller modulating a gas pressure of the pressurized aerosolizing gas in the aerosolizing space to exceed and decreases below a liquid pressure at the fluid exit in an alternating fashion, controlling an aerosol generation duration by the period of time the pressurized aerosolizing gas pressure is maintained by the controller below the liquid pressure at the fluid exit.
A61M 16/10 - Préparation de gaz ou vapeurs à respirer
A61M 11/02 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression d'air sur les liquides à pulvériser ou vaporiser
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
A61M 16/20 - Valves spécialement adaptées aux dispositifs respiratoires médicaux
An aerosol concentrator dividing an input aerosol into a respirable aerosol of an increased particle concentration and an exhaust aerosol of a lower particle concentration. The concentrator comprises a cross-slit of an input tube and output tube with a gap between the cross-slits of input tube and the output tube. A housing encompasses a plenum which encompasses the gap and is connected to an exhaust port through which an exhaust aerosol exits the plenum.
A system and a method for generating a respirable aerosol from a liquid solution or liquid suspension. A liquid solution or liquid suspension is supplied at a liquid pressure, and a pressurized aerosolizing gas is supplied at a pressurized aerosolizing gas pressure to an aerosol generating nozzle having an aerosol exit orifice through which the liquid solution or liquid suspension is released into an aerosolizing space. Controlling the pressure of an aerosolizing gas by a controller modulates a gas pressure of the pressurized aerosolizing gas in the aerosolizing space to alternatingly exceed above and drop below a fluid pressure at the fluid exit, controlling an aerosol generation duration by the time the pressurized aerosolizing gas pressure is kept by the controller below the fluid pressure at the fluid exit.
A61M 16/14 - Préparation de gaz ou vapeurs à respirer par mélange de fluides différents, l'un d'entre eux étant en phase liquide
A61M 11/02 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression d'air sur les liquides à pulvériser ou vaporiser
A61M 16/20 - Valves spécialement adaptées aux dispositifs respiratoires médicaux
An aerosol concentrator dividing an input aerosol into a respirable aerosol of an increased particle concentration and an exhaust aerosol of a lower particle concentration. The concentrator comprises a cross-slit of an input tube and output tube with a gap between the cross-slits of input tube and the output tube. A housing encompasses a plenum which encompasses the gap and is connected to an exhaust port through which an exhaust aerosol exits the plenum. A radial size of the plenum is can be significantly larger than the length of the slits in the cross-slit.
An aerosol generating system for generating a respirable dry powder aerosol from a liquid solution or liquid suspension, having: a liquid aerosol generating nozzle having a nozzle input end designed to receive the liquid solution or liquid suspension, and having a nozzle heliox supply designed to receive nozzle heliox, the liquid aerosol generating nozzle further having a nozzle output end for outputting a liquid aerosol suspended in the nozzle heliox; and a cylindrical evaporation chamber having a cylindrical evaporation chamber input end that is connected to the nozzle output end and connected to a dilution heliox supply for receiving both the liquid aerosol suspended in the nozzle heliox and for receiving the dilution heliox, and the cylindrical evaporation chamber having a cylindrical evaporation chamber output end outputting a first intermediate dry powder aerosol at a first intermediate dry powder aerosol volume flow of a specific concentration.
A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
A61M 11/02 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression d'air sur les liquides à pulvériser ou vaporiser
A61M 16/12 - Préparation de gaz ou vapeurs à respirer par mélange de gaz différents
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
A61M 11/06 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux du type injecteur
F26B 3/12 - Procédés de séchage d'un matériau solide ou d'objets impliquant l'utilisation de chaleur par convection, c.-à-d. la chaleur étant transférée d'une source de chaleur au matériau ou aux objets à sécher par un gaz ou par une vapeur, p. ex. l'air le gaz ou la vapeur entraînant le matériau ou les objets à sécher sous forme d'une pulvérisation
6.
Apparatus and method for generating particle aerosols with heliox
A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated. The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.
A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
A61M 11/02 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression d'air sur les liquides à pulvériser ou vaporiser
A61M 16/12 - Préparation de gaz ou vapeurs à respirer par mélange de gaz différents
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
A61M 11/06 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux du type injecteur
F26B 3/12 - Procédés de séchage d'un matériau solide ou d'objets impliquant l'utilisation de chaleur par convection, c.-à-d. la chaleur étant transférée d'une source de chaleur au matériau ou aux objets à sécher par un gaz ou par une vapeur, p. ex. l'air le gaz ou la vapeur entraînant le matériau ou les objets à sécher sous forme d'une pulvérisation
7.
APPARATUS AND METHOD FOR GENERATING AND CONCENTRATING FINE PARTICLE AEROSOLS
A61M 11/04 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression de la vapeur des liquides à pulvériser ou vaporiser
A61M 16/10 - Préparation de gaz ou vapeurs à respirer
A61M 16/14 - Préparation de gaz ou vapeurs à respirer par mélange de fluides différents, l'un d'entre eux étant en phase liquide
A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
8.
Apparatus and method for generating and concentrating fine particle aerosols
A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated by a cylindrical single linear slit aerosol concentrator (9). The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.
A61M 11/02 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression d'air sur les liquides à pulvériser ou vaporiser
A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
A61M 16/14 - Préparation de gaz ou vapeurs à respirer par mélange de fluides différents, l'un d'entre eux étant en phase liquide
A61M 11/04 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression de la vapeur des liquides à pulvériser ou vaporiser
A61M 11/06 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux du type injecteur
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
9.
Two-stage apparatus and method for generating and concentrating fine particle aerosols
A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated by a cylindrical single linear slit aerosol concentrator (9). The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
A61M 11/02 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression d'air sur les liquides à pulvériser ou vaporiser
A61M 16/12 - Préparation de gaz ou vapeurs à respirer par mélange de gaz différents
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
10.
Aerosolizing nozzle and method of operating such aerosolizing nozzle
A nozzle and a method of generating an inhalable aerosol from a liquid solution or liquid suspension and a gas by operating the nozzle. A column-like aerosol plume is generated having fluid particles within a particle free sheath of gas, the aerosol plume being generated from a compressed gas interacting within the aerosolizing space with a fluid ejected along the central axis, and generates a Venturi effect entraining gas that flows over the convex outer nozzle surface that together with the particle free sheath keeps the circumferential edge and the outer nozzle surface free of particle deposition. An aerosol exit orifice diameter is at least 1.3 times larger than the fluid exit orifice diameter; and a converging annular pressurized gas channel extending at an acute gas flow angle of 10-30° with respect to a central axis.
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B05B 1/02 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour produire un jet, un pulvérisat ou tout autre écoulement de forme ou de nature particulière, p. ex. sous forme de gouttes individuelles
B05B 7/12 - Pistolets pulvérisateursAppareillages pour l'évacuation agencés pour commander le volume débité, p. ex. à l'aide de passages réglables
B05B 7/10 - Pistolets pulvérisateursAppareillages pour l'évacuation produisant une turbulence à la sortie
B05B 7/06 - Pistolets pulvérisateursAppareillages pour l'évacuation avec un orifice de sortie en entourant un autre situé approximativement dans le même plan
A61M 11/06 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux du type injecteur
A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
11.
AEROSOLIZING NOZZLE AND METHOD OF OPERATING SUCH AEROSOLIZING NOZZLE
A nozzle and a method of generating an aerosol from a fluid and a gas by operating the nozzle. The nozzle has an aerosol exit orifice of a larger diameter and a fluid exit orifice of a smaller diameter aligned on a common central axis. A pressurized gas from a pressurized gas exit in close proximity to the fluid exit orifice intersects a fluid jet exiting from the fluid exit orifice at that acute angle and in a distance from the aerosol exit orifice. The method includes aerosolizing a fluid with a viscosity exceeding 4 cSt delivering an inhalable medication at a rate of more than 1 ml/minute, thereby delivering a medication at a mass flow rate of at least 30 mg/minute in form of the fluid particles having a mass median aerodynamic diameter (MMAD) of 6 μιη or less.
A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
B05B 7/00 - Appareillages de pulvérisation pour débiter des liquides ou d'autres matériaux fluides provenant de plusieurs sources, p. ex. un liquide et de l'air, une poudre et un gaz
12.
Aerosolizing nozzle and method of operating such aerosolizing nozzle
A nozzle and a method of generating an aerosol from a fluid and a gas by operating the nozzle. The nozzle has an aerosol exit orifice of a larger diameter and a fluid exit orifice of a smaller diameter aligned on a common central axis. A pressurized gas from a pressurized gas exit in close proximity to the fluid exit orifice intersects a fluid jet exiting from the fluid exit orifice at that acute angle and in a distance from the aerosol exit orifice. The method includes aerosolizing a fluid with a viscosity exceeding 4 cSt delivering an inhalable medication at a rate of more than 1 ml/minute, thereby delivering a medication at a mass flow rate of at least 30 mg/minute in form of the fluid particles having a mass median aerodynamic diameter (MMAD) of 6 μm or less.
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B05B 1/02 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour produire un jet, un pulvérisat ou tout autre écoulement de forme ou de nature particulière, p. ex. sous forme de gouttes individuelles
A61M 11/06 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux du type injecteur
A61M 11/00 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux
B05B 7/12 - Pistolets pulvérisateursAppareillages pour l'évacuation agencés pour commander le volume débité, p. ex. à l'aide de passages réglables
B05B 7/10 - Pistolets pulvérisateursAppareillages pour l'évacuation produisant une turbulence à la sortie
Machine for the generation and delivery of aerosols and vapors for non-medical purposes, specifically for generation and delivery of drugs, toxins, nano-particles, biologics, polymers, sols, large molecules, solutions of such molecules as well as viscous solutions of large molecules and vapors derives from fluids. Device for the generation and delivery of aerosolized drugs and other agents, specifically for generation and delivery of aerosols, nano-particles and vapors of respirable biologics, polymers, sols, large molecules, solutions of such molecules as well as viscous solutions of large molecules; inhalers sold empty. Apparatus for use in vaporizing for medical and non-medical purposes, specifically for generation of delivery of drugs, toxins, nano-particles, biologics, polymers, sols, large molecules, solutions of such molecules as well as viscous solutions of large molecules and vapors derives from fluids.
Machine for the generation and delivery of aerosols and vapors for non-medical purposes, specifically for generation and delivery of drugs, toxins, nano-particles, biologics, polymers, sols, large molecules, solutions of such molecules as well as viscous solutions of large molecules and vapors derived from fluids. Aerosol inhalers for medical purposes, specifically for generation and delivery of drugs, toxins, nano-particles, biologics, polymers, sols, large molecules, solutions of such molecules as well as viscous solutions of large molecules and vapors derived from fluids; inhalers sold empty. Apparatus for use in vaporizing for medical and non-medical purposes, specifically for generation and delivery of drugs, toxins, nano-particles, biologics, polymers, sols, large molecules, solutions of such molecules as well as viscous solutions of large molecules and vapors derived from fluids.
15.
Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery
A method and system is disclosed which is capable of delivering at a high dose rate, respirable solid aerosols derived from aqueous- or nonaqueous-based solutions containing the desired therapeutic agent(s). The method and system comprises the integration of an aerosol generator, an aerosol evaporator, an aerosol concentrator, and an aerosol flow regulator. The aerosol generator generates 10-30 μm droplets, with a narrow size distribution. The aerosol jet is arrested by a coaxial counter-flow heated air jet, and evaporated rapidly by annular swirling heated air. Most of the air, together with the unwanted solvent vapor, is removed from the aerosol stream during the process of aerosol concentration. The output aerosol carries the dry particles to be inhaled by the patient. The respiratory-governed control of aerosol fluid generation system delivers fluid containing the test agent of interest (drug or toxin) to the aerosol generator throughout inhalation.
