INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Université Paris-Sud (France)
Inventeur(s)
Dore, Joël
Faivre, Jamila
Moniaux, Nicolas
Brechot, Christian
Darnaud, Marion
Abrégé
The present disclosure concerns a Reg3α polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for protecting oxygen sensitive gram-positive bacteria, compositions including the polypeptide, and their use. The disclosure shows that increasing concentration of the hReg3α lectin into the gastrointestinal tract (GIT) lumen of hReg3α-transgenic mice induced significant changes in composition of gut microbiota, and dramatically improved host resistance to intestinal inflammation. The Reg3α polypeptide may be used for preventing or treating microbiota-related diseases and/or disorders, including inflammatory bowel disease (IBD), colitis, gastrointestinal infections, irritable bowel syndrome and other gastrointestinal functional diseases, gastrointestinal tract cancer, metabolic syndrome and obesity, diabetes, liver diseases, allergic diseases, neurodegenerative diseases and psychological disorders, and the prevention and treatment methods may also include transferring to said patient fecal microbiota from a human or animal expressing the Reg3α polypeptide.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Université Paris-Sud (France)
Inventeur(s)
Dore, Joël
Faivre, Jamila
Moniaux, Nicolas
Brechot, Christian
Darnaud, Marion
Abrégé
The invention concerns a Reg3α polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for protecting oxygen sensitive gram-positive bacteria, compositions comprising the polypeptide, and their use. The inventors showed that increasing concentration of the hReg3α lectin into the gastrointestinal tract (GIT) lumen of hReg3α-transgenic mice induced significant changes in composition of gut microbiota, and dramatically improved host resistance to intestinal inflammation. hReg3α exerted a potent antioxidant activity on intestinal epithelial cells during colitis, and the ROS scavenging activity, by promoting the survival of highly oxygen sensitive bacteria. Inventors also showed that hReg3α-transgenic mice were better able to resist DSS-induced colitis after antibiotherapy. The Reg3α polypeptide may be used for preventing or treating microbiota-related diseases and/or disorders, including inflammatory bowel disease (IBD), colitis, gastrointestinal infections, irritable bowel syndrome and other gastrointestinal functional diseases, gastrointestinal tract cancer, metabolic syndrome and obesity, diabetes, liver diseases, allergic diseases, neurodegenerative diseases and psychological disorders.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
Fafournoux, Pierre
Bruhat, Alain
Jousse, Celine
Maurin, Anne-Catherine
Averous, Julien
Abrégé
An expression cassette including a gene of interest under the control of an inducible promoter, characterized in that said inducible promoter includes at least one CARE regulatory sequence (C/EBP-ATF responsive element) and a minimal promoter. Also, a vector and a host cell, as well as to a pharmaceutical composition including such a cassette, and to the use thereof for treating diseases by gene therapy.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
Association pour les Transferts de Technologies du Mans (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
THE OHIO STATE UNIVERSITY (USA)
UNIVERSITE D'ANGERS (France)
Institut National Supérieur des Sciences (France)
Inventeur(s)
Bosselut, Julien
Sakr, Soulaiman
Le Bras, Camille
Cornish, Katrina
Abrégé
The present invention concerns a method for culturing a plant, said method comprising a culture step wherein said plant is submitted to repeated thermal cycles, wherein, for each thermal cycle, cool temperature and warm temperature are alternately artificially applied to all or a part of said plant, over a period shorter than natural seasons.
The present invention concerns a method for culturing a plant, said method comprising a culture step wherein said plant is submitted to repeated thermal cycles, wherein, for each thermal cycle, cool temperature and warm temperature are alternately artificially applied to all or a part of said plant, over a period shorter than natural seasons.
The present invention also concerns a method for producing natural rubber from latex-producing plants, said method comprising the steps of (a) culturing the latex-producing plant by implementing the method of culture of the invention, (b) harvesting part or all of root part of said plant, and (c) extracting natural rubber from the root part harvested at step b).
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INSTITUT DES SCIENCES ET INDUSTRIES DU VIVANT DE L'ENVIRONNE (France)
Inventeur(s)
Fraud, Sébastien
El Youssef, Cynthia
Bonarme, Pascal
Landaud-Liataud, Sophie
Helinck, Sandra
Abrégé
A modulated protein composition is described with improved flavor properties over a vegetable protein. Methods of making a modulated protein composition including the use of a volatile modulating yeast culture to ferment a vegetable protein to produce the modulated protein composition are described. Also disclosed are a fermented vegetable composition made from a modulated protein composition, and ingredients and foods including a fermented vegetable composition or a modulated protein composition.
A23L 27/00 - ÉpicesAgents aromatiques ou condimentsÉdulcorants artificielsSels de tableSubstituts diététiques du selLeur préparation ou leur traitement
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
INSTITUT DES SCIENCES ET INDUSTRIES DU VIVANT ET DE L'ENVIRONNEMENT - AGROPARISTECH (France)
Inventeur(s)
Cordella, Christophe
Abrégé
The invention relates to the field of monitoring the state of health of bees. More specifically, it relates to a biosensor capable of detecting the qualitative and quantitative modifications in the atmosphere inside the hive in the event of intoxication or diseases within the bee colony. It also relates to a system for remotely monitoring the state of health of a bee colony using such a biosensor.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (France)
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (France)
ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (France)
ECOLE D'INGENIEURS DE PURPAN (France)
Inventeur(s)
Langella, Philippe
Miquel, Sylvie
Martin Rosique, Rebeca
Bermudez Humaran, Luis
Thomas, Muriel
Sokol, Harry
Carvalho, Frédéric
Theodorou, Vassilia
Abrégé
Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual.
The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.
A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
8.
METHOD FOR INCORPORATING FREE AMINO ACIDS INTO A PRODUCT BASED ON PLANT PROTEINS
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Le Bourgot, Cindy
Redl, Andreas
Rémond, Didier
Abrégé
The invention relates to a method for incorporating at least one amino acid within a composition comprising plant proteins. The method comprises the steps of kneading a mixture of plant proteins with at least one plasticizer and at least one free acid. The mixture is then heated, preferably by static heating at a temperature of 120 to 160 °C, then cooked in water. The invention also relates to a composition obtainable by this method and to foods comprising it.
INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE (INPT) (France)
ECOLE D'INGENIEURS DE PURPAN (France)
UNIVERSITE PAUL SABATIER TOULOUSE III (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Torre, Jean-Philippe
Pages-Homs, Marielle
Violleau, Frédéric
Manero, Marie-Hélène
Richard, Romain
Abrégé
The present invention relates to a method and a unit for preparing a solid material for storing ozone, said method comprising contacting cyclodextrins and/or derivatives of cyclodextrins in solid form with a gas comprising ozone, by means of which a solid material for storing ozone is obtained. The present invention also relates to the material thus prepared and to the uses thereof.
A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
C01B 13/00 - OxygèneOzoneOxydes ou hydroxydes en général
C02F 1/78 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par oxydation au moyen d'ozone
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITÉ DE BORDEAUX (France)
UNIVERSITÉ D'AIX MARSEILLE (France)
ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE (France)
COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA) (France)
SORBONNE UNIVERSITÉ (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Tregouet, David-Alexandre
Morange, Pierre-Emmanuel
Deleuze, Jean-François
Abrégé
PLXDC2PLXDC2PLXDC2 rs927826 polymorphism explaining ~3.7% (p 7.5 10 -15PLXDC2PLXDC2PLXDC2 gene would be suitable for identifying a subject having or at risk of having a coagulation related disorder.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
11.
POLYSACCHARIDE COMPOUNDS AND USE OF SAME FOR STIMULATING DEFENCE RESPONSES OF PLANTS AGAINST PATHOGENIC MICROORGANISMS
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA - (France)
UNIVERSITE DE PICARDIE JULES VERNE (France)
INSTITUT NATIONAL SUPERIEUR DES SCIENCES AGRONOMIQUES DE L'ALIMENTATION ET DE L'ENVIRONNEMENT (AGROSUP DIJON) (France)
Inventeur(s)
Wendehenne, David
Combier, Maud
Poinssot, Benoit
Pelloux, Jérôme
Bonnin, Estelle
Crepeau, Marie-Jeanne
Jeandroz, Sylvain
Abrégé
The present invention relates to novel oligogalacturonans having a degree of methylation of 0 and a degree of polymerisation of 1 to 10, and to the use thereof for stimulating defence responses of plants against pathogenic microorganisms.
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
UNIVERSITÉ PAUL SABATIER TOULOUSE III (France)
Inventeur(s)
Heymes, Christophe
Burcelin, Rémy
Chatel, Jean-Marc
Langella, Philippe
Abrégé
F.prausnitziiprausnitzii and were shown as deriving from a single Microbial Anti- inflammatory Molecule (MAM). The inventors shows that L-MAM treatment prevented animals from development of High-Fat Diet- induced obesity. L-MAM treated mice significantly gained less weight throughout the gavage as compared to HFD-fed control experiment. The difference in body weight between L-MAM-treated animals on a HFD and the remaining animals is largely due to a significant reduction in the percentage of fat mass and a significant increase in the percentage of lean mass. Oral glucose tolerance testing (OGTT) revealed that chronic administration of L-MAM increased glucose tolerance. Finally, all adipose tissues weights were lower in L-MAM- treated mice. Accordingly, the present invention relates to the use of MAM polypeptides for the treatment of obesity and obesity-related disorders.
INSTITUT NATIONAL DE RECHERCHE EN SCIENCES ET TECHNOLOGIES POUR L'ENVIRONNEMENT ET L'AGRICULTURE (IRSTEA) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Bergel, Alain
Bernet, Nicolas
Blanchet, Elise
Bouchez, Théodore
Erable, Benjamin
Etcheverry, Luc
Huyard, Alain
Le Quemener, Elie
Mauricrace, Pierre
Moreau, Sylvain
Tian, Jianghao
Trably, Eric
Abrégé
The invention relates to a bioelectrochemical reactor (1) which comprises: - an anode chamber (11) having at least two bioanodes (12, 13), and an anodic electrolyte (14) comprising anodic electroactive microorganisms, - a cathode chamber (21) comprising at least one biocathode (22), and a cathodic electrolyte (24) comprising cathodic electroactive microorganisms, - the anode chamber (11) being separated from the cathode chamber (21) by, running from the anode chamber to the cathode chamber, a cation exchange membrane (31) and an anion exchange membrane (32), said cation and anion exchange membranes being separated from each other by an inter-membrane chamber (30), and - means for applying a potential difference between the interconnected bioanodes and the biocathode/biocathodes, the bioanodes and biocathode/biocathodes having active surfaces such that the total active surface of the biocathode/biocathodes (22) is greater than the total active surface of the two bioanodes (12, 13). The invention also relates to a method for regenerating the activity of the bioanodes of the reactor and to the use of said reactor for the electrosynthesis of organic acids and/or alcohols from organic waste.
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITÉ DE NANTES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES (France)
Inventeur(s)
Cariou, Bertrand
Magnan, Antoine
Bouchaud, Grégory
Le May, Cédric
Abrégé
The present invention relates to allergy field. Several independent groups have recently investigated the implication of PCSK9 on inflammation and sepsis but none of them have determine its impact on allergies and/or asthma which is a global health burden. Inventors have obtained preliminary data on wild-type (PCSK9+/+) or PCSK9-deficient mice (PCSK9-/-) and shown that, under basal condition and in the absence of a particular stimulus, PCSK9 deficiency significantly increases the percentage of regulatory T cells in the spleen, the mesenteric lymph nodes and Peyer's patches. Moreover, inventors have shown the effect of allergic challenge on primary human bronchial epithelial cells on PCSK9 expression and secretion. Very interestingly, their first results obtained by Q-PCR showed that HDM and LPS increase PCSK9 mRNA levels. Accordingly, the present invention relates to inhibitors of PCSK9 for use in the treatment of asthma and/or allergic disease, such as food allergy.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
UNIVERSIDADE FEDERAL DE MINAS GERAIS (Brésil)
INSTITUT SUPÉRIEUR DES SCIENCES AGRONOMIQUES, AGROALIMENTAIRES, HORTICOLES ET DU PAYSAGE (France)
Inventeur(s)
Jan, Gwénaël
Le Loir, Yves
Valence, Florence
De Carvalho Azevedo, Vasco Ariston
Dias De Oliveira Carvalho, Rodrigo
Rosa Do Carmo, Fillipe Luiz
Cordeiro, Barbara Fernandes
Abrégé
The present invention relates to the field of probiotics. More particularly, the present invention relates to a composition comprising at least one bacterial strain pertaining to the genus Propionibacterium for use in the treatment or prevention of mucositis in a subject, preferably for the treatment or prevention of the alteration of tight junctions of epithelial tissue associated with mucositis.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
UNIVERSITE DE LORRAINE (France)
UNIVERSITE CLERMONT AUVERGNE (France)
Inventeur(s)
Dardevet, Dominique
Auzeloux, Isabelle
Jarzaguet, Marianne
David, Jérémie
Chatel, Jean-Marc
Dary-Mourot, Annie
Cherbuy, Claire
Langella, Philippe
Abrégé
Streptococcus thermophilusStreptococcus thermophilus species with reference CNRZ160 for use in the prevention and/or treatment of intestinal inflammation in an individual.
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITÉ PARIS DIDEROT - PARIS 7 (France)
ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Monteiro, Renato
Lepage, Patricia
Ben Mkaddem, Sanae
Chemouny, Jonathan
Berthelot, Laureline
Gleeson, James
Abrégé
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. IgA is mainly produced by the gut associated lymphoid tissue (GALT). Both experimental and clinical data suggest a role of the gut microbiota in this disease. The inventors aimed to determine if an intervention targeting the gut microbiota could impact disease development in a humanized mouse model of IgAN, the α1KI-CD89TG mice. Four- week old mice were divided into two groups to receive either antibiotics or vehicle-control by oral gavage twice a week for eight weeks. Antibiotic treatment efficiently depleted the faecal microbiota, impaired GALT architecture and impacted mouse IgA production. However, while hlgA1 and mIgG serum levels were unchanged, the antibiotic treatment markedly prevented hlgA1 mesangial deposition, glomerular inflammation and the development of proteinuria. This was associated with a significant decrease in circulating hlgA1-mIgG complexes. These data support that use of antibiotics would be suitable for the treatment of immunoglobulin A nephropathy.
A61K 31/43 - Composés contenant des systèmes cycliques thia-4 aza-1 bicyclo [3.2.0] heptane, c.-à-d. composés contenant un système cyclique de formule , p. ex. pénicillines, pénèmes
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
19.
METHOD FOR CRUSHING A MINERAL MATERIAL IN THE PRESENCE OF AT LEAST ONE GRINDING AID
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Mayer, Claire
Blanc, Nicolas
Delenne, Jean-Yves
Motte, Jean-Charles
Rouau, Xavier
Abrégé
The invention concerns a method for crushing a mineral material, which method comprises: -a step of providing said mineral material to be crushed and at least one grinding aid, said at least one grinding aid is chosen from organic plant materials in order to form a plant grinding aid, - a step of crushing said mineral material in the presence of said at least one grinding aid. And, according to the invention, said at least one grinding aid is composed of particles. And in the course of the crushing step, the at least one plant grinding aid is mixed with the mineral material in a proportion by mass less than 5% of the total mass.
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE BREST (France)
UNIVERSITÉ DE BRETAGNE OCCIDENTALE (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
ETABLISSEMENT FRANÇAIS DU SANG (EFS) (France)
Inventeur(s)
Hery-Arnaud, Geneviève
Mounier, Jérôme
Guilloux, Charles-Antoine
Lepage, Patricia
Mondot, Stanislas
Keravec, Marlène
Abrégé
P. aeruginosaP. aeruginosaPorphyromonas catoniaeP. aeruginosaPorphyromonas catoniaePorphyromonas catoniae in a biological sample obtained from said subject.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
21.
METHODS AND COMPOSITION FOR THE TREATMENT OF ALLERGIC ASTHMA
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
UNIVERSITÉ DE NANTES (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Bouchaud, Grégory
Magnan, Antoine
Abrégé
The present invention relates to a method of treating allergic asthma in a subject in need thereof comprising a step of administering to said subject a therapeutically effective amount of a polypeptide comprising or consisting of a biologically active fragment of the house-dust mite Dermatophagoides pteronyssinus Der p 2.1. Inventors have used a model allergy in a severe asthma allergic (mouse Balbc). They have surprisingly found that when they injected twice the polypeptide derp2.1 in the mouse model after a third asthma attack, the mouse presents a respiratory improvement, reduction of neutrophils and eosinophils in the broncho-alveolar lavage (BAL), an increase of regulators lymphocytes T and reduction of natural killer cells in the BAL. Thus, the polypeptide derp2.1 is a new tool to treat the allergic asthma by a restoration of lung function and reduction of inflammatory environment.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
Institut National de la Recherche Agronomique (INRA) (France)
Inventeur(s)
Pitiot, Christelle
Laurens, François
Abrégé
A new apple tree named ‘Inobi’ notable for its attractive fruit, favorable organoleptic qualities and resistance to apple scab. Fruit of ‘Inobi’ is highly colored and has a long shelf life.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
TERRES INOVIA (France)
AVRIL (France)
Inventeur(s)
Aouf, Chahinez
Fine, Frédéric
Abrégé
The invention relates to a method of preparing a compound of formula (I), comprising a step of reacting a mixture of at least one phenolic compound of the following formula (III), with at least one base. The invention also relates to a method of preparing polymers, and polymers obtained using this method.
C07D 303/28 - Éthers avec des composés hydroxylés contenant des cycles oxirane
C07C 43/23 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons contenant des groupes hydroxyle ou O-métal
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Cathala, Bernard
Berrin, Jean-Guy
Villares, Ana
Moreau, Céline
Abrégé
The present invention generally relates to the field of celluloses, in particular nanocelluloses, and more particularly to methods for producing cellulosic fibres and defibrillating cellulosic substrates. In particular, the invention relates to methods for defibrillating cellulosic substrates and producing celluloses, in particular nanocelluloses (NC), using a new family of fungal lytic polysaccharide monooxygenases (LPMO).
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
UNIVERSITÉ PARIS-SUD (France)
Inventeur(s)
Dore, Joël
Faivre, Jamila
Moniaux, Nicolas
Brechot, Christian
Darnaud, Marion
Abrégé
Faecalibacterium prausnitziiRoseburia intestinalisRoseburia intestinalis; pharmaceutical compositions comprising the polypeptide and their use; and the use of this polypeptide for promoting ex vivo growth of oxygen sensitive gram-positive bacteria. The Reg3α polypeptide may be used for preventing or treating microbiota-related disease and/or disorder, particularly selected from inflammatory bowel disease (IBD), colitis, gastrointestinal infections, irritable bowel syndrome and other gastrointestinal functional diseases, gastrointestinal tract cancer, metabolic syndrome and obesity, diabetes, liver diseases, allergic diseases, neurodegenerative diseases and psychological disorders.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A23L 5/00 - Préparation ou traitement des aliments ou produits alimentaires en généralAliments ou produits alimentaires ainsi obtenusLeurs matériaux
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
27.
EXTRACT OF KNOTS FROM TREES BELONGING TO THE GENUS PINUS AS FUNGICIDE AGAINST OOMYCETES INFECTIONS
ÉCOLE NATIONALE SUPÉRIEURE DES SCIENCES AGRONOMIQUES DE BORDEAUX AQUITAINE (BORDEAUX SCIENCES AGRO) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA (France)
ACTICHEM (France)
Inventeur(s)
Richard, Tristan
Merillon, Jean-Michel
Gabaston, Julien
Corio-Costet, Marie-France
Biais, Benoît
Izard, Jean-Claude
Abrégé
The present invention relates to the use of an extract of knots from trees belonging to the genus Pinus for the treatment of a pathogenic infection due to at least one oomycete. The invention also relates to the extracts obtained by extraction of knots from trees belonging to the genus Pinus, the process for obtaining same, and also the use thereof as fungicide and/or algicide and especially for the treatment of a pathogenic infection due to at least one oomycete.
A01N 65/06 - Coniferophyta [gymnospermes], p. ex. cyprès
A01N 27/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des hydrocarbures
A01N 37/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques
A61K 36/15 - Pinaceae (famille du pin), p. ex. pin ou cèdre
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INOVIAFLOW (France)
Inventeur(s)
Salon, Christophe
Jeudy, Christian
Baussart, Christophe
Chazallet, Fédéric
Lamboeuf, Mickael
Martinet, Julien
Abrégé
Apparatus to acquire an image of roots of a plant located in a target rhizotron, said apparatus comprising: a turntable (12) having a rotation axis (X) and intended to support said target rhizotron; a lightening device (14); an first camera (16) having an optical axis (O) substantially oriented toward said rotation axis (X); a focus sensor (18) arranged so as to provide a measure (M) of at least one parameter of the first camera; a control module (20), configured to receive said measure (M), compare said measure (M) to comparison data (C), and inform an operator accordingly, the comparison data comprising data related to reference rhizotrons different than said target rhizotron, and/or data related to one or several previously acquired images of the target rhizotron.
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c.-à-d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE (INSAT) (France)
Inventeur(s)
Senez, Vincent
Vlandas, Alexis
Lamant, Sébastien
Cathala, Bernard
Moreau, Céline
Veronese, Gabrielle
Bozonnet, Sophie
Laville, Elisabeth
Cleret, Mégane
Abrégé
The present invention relates to a method for detecting the sensitivity of one or more polymers and/or one or more polymer blends to a compound, comprising the steps of: exposing a plurality of individual micro-deposits comprising the polymer(s) and/or polymer blend(s) to the compound; and, with the aid of interferometry, detecting a variation in the appearance of a group of micro-deposits exposed to the compound and/or a variation in the dimensions and/or the refractive index of at least one of the micro-deposits exposed to the compound, linked to an interaction between the polymer(s) and/or polymer blend(s) and the compound.
G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique
31.
STABILIZED PROTEIN AGGREGATE PARTICLES, AND PROCESS FOR THE PREPARATION OF SAID PARTICLES
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
INSTITUT SUPÉRIEUR DES SCIENCES AGRONOMIQUES, AGROALIMENTAIRES, HORTICOLES ET DU PAYSAGE (AGRO CAMPUS OUEST) (France)
Inventeur(s)
Famelart, Marie-Hélène
Croguennec, Thomas
Schuck, Pierre
Schong, Elise
Sevrin, Thomas
Abrégé
The present invention concerns a process for the preparation of stabilized protein aggregate particles, wherein said process comprises the following steps: a) providing an aqueous solution wherein are dispersed proteins and at least one reducing sugar, b) adjusting the pH of the aqueous solution obtained in step a), to a pH above 7, c) drying the aqueous solution obtained in step b), to form powder particles comprising said proteins and said at least one reducing sugar, d) dry heating said powder particles obtained in step c), to form said stabilized protein aggregate particles.
A23C 1/14 - Concentration, évaporation ou séchage combinés avec un autre traitement
A23C 1/16 - Concentration, évaporation ou séchage combinés avec un autre traitement comportant l'emploi d'additifs
A23C 9/152 - Préparations à base de laitLait en poudre ou préparations à base de lait en poudre comportant des additifs
A23C 9/154 - Préparations à base de laitLait en poudre ou préparations à base de lait en poudre comportant des additifs contenant des substances épaississantes, des œufs ou des préparations à base de céréalesLait gélifié
A23C 9/156 - Préparations aromatisées à base de lait
A23C 9/16 - Agglomération ou granulation du lait en poudreFabrication du lait en poudre à solubilité instantanéeProduits obtenus
A23C 21/06 - Mélanges de petit-lait avec des produits laitiers ou des constituants du lait
A23C 21/08 - Petit-laitPréparations à base de petit-lait contenant d'autres additifs organiques, p. ex. des produits végétaux ou animaux
A23J 3/00 - Traitement des protéines pour l'alimentation
A23L 33/125 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sirops d'hydrate de carboneModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sucresModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des alcools de sucreModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des hydrolysats d'amidon
32.
METHOD FOR ELECTROCHEMICAL DETECTION OF MYCOBACTERIA
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA - (France)
Inventeur(s)
Rochelet, Murielle
Barbier, Élodie
Hartmann, Alain
Abrégé
The present invention relates to a novel process for biological detection of mycobacteria via electrochemical analysis methods of the catalytic activity of antigen 85.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
G01N 27/00 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques
33.
PERINATAL ADMINISTRATION OF SHORT-CHAIN FRUCTOOLIGOSACCHARIDES IN ORDER TO PREVENT METABOLIC DISORDERS LINKED TO AN UNBALANCED DIET AT ADULT AGE
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Le Bourgot, Cindy
Apper, Emmanuelle
Le Huërou-Luron, Isabelle
Blat, Sophie
Abrégé
The invention relates to a method for preventing metabolic disorders linked to an unbalanced diet at adult age in offspring or to a method for stimulating the intestinal endocrine function and for increasing the sensitivity of the pancreas with respect to glucose at adult age in a mammal, or for preventing glucose homeostasis insufficiency at adult age in a mammal or to a method for reducing sensitivity to inflammations at adult age in a mammal, by administration of ScFOS to the female animal during the gestation of said offspring and/or the breastfeeding of said offspring and/or to said offspring for at least two weeks after weaning.
A61K 31/7016 - Disaccharides, p. ex. lactose, lactulose
A61K 31/702 - Oligosaccharides, c.-à-d. ayant trois à cinq radicaux saccharide liés les uns aux autres par des liaisons glycosidiques
A61P 3/08 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose
A61P 1/18 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles pancréatiques, p. ex. enzymes pancréatiques
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
De Langre, Emmanuel
Hemon, Pascal
Penalver, Olivier
Frachisse, Jean-Marie
Moulia, Bruno
Abrégé
A device comprising: - an oscillator (16) suitable for setting in free oscillation the aerial part of a plant (P) arranged in a test location (E); - a camera (18) for acquiring a series of images of said plant; and - an analysis module (20) for analysing said images, configured to determine, for each of said images and by an analysis of all of the pixels of said image, a property of said image, then to evaluate a characteristic relating to the change over time of said property.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
G06K 9/46 - Extraction d'éléments ou de caractéristiques de l'image
35.
ANTIGENIC TRIPEPTIDES DERIVED FROM MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS S-TYPE STRAINS, DERIVATIVES AND USES THEREOF
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (USA)
Inventeur(s)
Bannantine, John P.
Etienne, Gilles
Bay, Sylvie
Biet, Franck
Abrégé
The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
C07K 5/087 - Tripeptides la chaîne latérale du premier amino-acide contenant des carbocycles, p. ex. Phe, Tyr
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
36.
MICROBIOTA COMPOSITION, AS A MARKER OF RESPONSIVENESS TO ANTI-PD1/PD-L1/PD-L2 ANTIBODIES AND USE OF MICROBIAL MODULATORS FOR IMPROVING THE EFFICACY OF AN ANTI-PD1/PD-L1/PD-L2 AB-BASED TREATMENT
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (France)
UNIVERSITE PARIS-SUD (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Zitvogel, Laurence
Routy, Bertrand
Le Chatelier, Emmanuelle
Abrégé
The invention relates to gut microbiota profiles associated with response or resistance to treatments with ICB, in particular with anti-PD1 or anti PD-L1or anti-PD-L2 antibodies. In particular, the invention pertains to a theranostic method for identifying good responders, to whom an anti-PD1 or anti PD-L1 or anti-PD-L2 can be administered, while a pre-treatment based on FMT and/or immunogenic probiotics is recommended to bad responders exhibiting a dysbiosis. In particular, the present invention pertains to Akkermansia muciniphila as the main commensal species distinguishing responders from progressors and its use alone or with E. hirae for the treatment of antibiotics or gut repertoire insufficieny-associated dysbiosis.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
37.
POLYSACCHARIDE-OXIDIZING COMPOSITION AND USES THEREOF
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
UNIVERSITE AIX MARSEILLE (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
Berrin, Jean-Guy
Couturier, Marie
Henrissat, Bernard
Rosso, Marie-Noelle
Sulzenbacher, Gerlind
Ladeveze, Simon
Abrégé
The invention relates to a polysaccharide-oxidizing composition comprising a polysaccharide-oxidizing enzyme wherein, when the said polysaccharide-oxidizing enzyme is compared to the reference polypeptide of SEQ ID NO. 1 as described in the specification by using the BLAST-P comparison method, (i) the said polysaccharide- oxidizing enzyme possesses an amino acid identity of 20 % or more with the said reference polypeptide and (ii) the BLAST-P comparison method results in an E-value of 10 e -3 or less.
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
C12P 7/14 - Fermentation en plusieurs étapesFermentation avec différents types de micro-organismes ou avec réemploi de micro-organismes
C12P 7/10 - Éthanol en tant que produit chimique et non en tant que boisson alcoolique préparé comme sous-produit, ou préparé à partir d'un substrat constitué par des déchets ou par des matières cellulosiques d'un substrat constitué par des matières cellulosiques
38.
DIET CONTROLLED EXPRESSION OF A NUCLEIC ACID ENCODING A PRO-APOPTOTIC PROTEIN
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Fafournoux, Pierre
Abrégé
The instant invention relates to a nucleic acid for the controlled expression of a nucleic acid encoding a pro-apoptotic protein in an individual, comprising: - a regulatory polynucleotide comprising a minimal promoter and at least one AARE (amino acid response element) nucleic acid, said regulatory polynucleotide being activated in an individual upon consumption of a diet deficient in at least one essential amino acid; and - a nucleic acid encoding a pro-apoptotic protein, which is placed under the control of the said regulatory polynucleotide.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
A01K 67/027 - Nouvelles races ou races modifiées de vertébrés
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
39.
FUSION PROTEIN COMPRISING THE N PROTEIN OF A VIRUS OF THE PNEUMOVIRINAE SUBFAMILY
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Eleouet, Jean-François
Riffault, Sabine
Herve, Pierre-Louis
Abrégé
The invention relates to a fusion protein comprising a N protein from a virus of the Pneumovirinae subfamily, Pneumovirinae subfamily, useful in immunization and vaccination methods.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
SORBONNE UNIVERSITE (France)
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (France)
Inventeur(s)
Langella, Philippe
Martin Rosique, Rebeca
Bermudez Humaran, Luis
Chain, Florian
Sokol, Harry
Abrégé
The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.
A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
41.
NEW PEPTIDES HAVING ANTIMICROBIAL ACTIVITY AND NEW ENZYME CAPABLE OF CONVERTING L-CONFIGURED RESIDUE IN D-CONFIGURED AMINO ACID IN A PEPTIDE
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Benjdia, Alhosna
Guillot, Alain
Berteau, Olivier
Abrégé
The present invention relates to a new class of peptides having antibacterial activity and presentin D-amino acids and their uses. It also relates to a new enzyme presenting a peptide epimeras activity in vitro and in vivo, thereby being useful for modifying peptides in order to change th amino acid configuration from L to D.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Gontard, Nathalie
Guillaume, Carole
Sorli, Brice
Abrégé
The present invention relates to the use of a biopolymer as a sensitive material in a dielectric gas sensor for water vapor, carbon dioxide, and/or ethanol.
G01N 27/22 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la capacité
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Chapot-Chartier, Marie-Pierre
Langella, Philippe
Bermudez-Humaran, Luis
Martin Rosique, Rebeca
Bernard, Elvis
Abrégé
The present invention relates to a probiotic bacterial strain into which the gene encoding for a peptidoglycan O-acetyltransferase, or oatA gene, is inactivated, for use in the treatment and/or prevention of visceral abdominal inflammatory disorders in an individual.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INSTITUT SUPÉRIEUR DES SCIENCES AGRONOMIQUES, AGROALIMENTAIRES, HORTICOLES ET DU PAYSAGE (France)
Inventeur(s)
Jeantet, Romain
Huang, Song
Jan, Gwénaël
Schuck, Pierre
Le Loir, Yves
Chen, Xiao-Dong
Abrégé
The present invention relates to a method for preparing a probiotic powder comprising at least one probiotic bacterium, said method comprising: a) providing a probiotic biomass composition comprising at least one probiotic bacterium resulting from the culture of said probiotic bacterium in a whey-containing nutrient medium having a total solid content ranging from above 25 % by weight to up to 35 % by weight, based on the total weight of the said whey- containing nutrient medium; b) spray drying or freeze drying the said probiotic biomass provided at step a) so as to obtain the said probiotic powder.
A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
A61P 29/02 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS] sans effet anti-inflammatoire
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
A61K 35/747 - Lactobacilles, p. ex. L. acidophilus ou L. brevis
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
BERGEN TEKNOLOGIOVERFORING AS (Norvège)
Inventeur(s)
Fouilloux-Meugnier, Emmanuelle
Vidal, Hubert
Ruzzin, Jérôme
Abrégé
The present invention relates to a FGF19 polypeptide for its use as an agent increasing muscle fibers size, in the prevention and/or treatment of muscle atrophy in a mammal body.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Denery, Sandra
Mameri, Hamza
Gaudin, Jean-Charles
Snegaroff, Jacques
Brossard, Chantal
Larre, Colette
Tranquet, Olivier
Abrégé
The invention concerns an immunogenic composition comprising a polypeptide or a mixture of polypeptides comprising the N-terminal domain of an a-gliadin or a γ-gliadin, or a fragment of the N-terminal domain of an α-gliadin or a γ-gliadin; and at least one physiologically acceptable adjuvant.
AGRO INDUSTRIE RECHERCHES ET DEVELOPPEMENTS A.R.D. (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA (France)
Inventeur(s)
Ghisoni, Flora
Abrégé
The invention relates to a method for propagating yeast, for use in the production of a fermentation product from lignocellulosic biomass, including the steps that consist of: a. providing a reactor; b. placing in contact in said reactor: a population of yeasts capable of metabolising pentoses and hexoses, with 0.2 to 2.0 g of yeast solids per kg of prepared complete medium, raw marc from the pretreatment of the lignocellulosic biomass, with a solids content (MS) of 8 % to 15 %, nutrients, and cellulases, with 5 to 15 mg of proteins per gram of MS; and c. incubating the mixture at a temperature of 25 ºC to 38 °C, preferably 28 ºC to 33 °C, in microaerobiosis, in which the saccharification of the raw marc and the growth of the yeast are carried out simultaneously.
C12P 7/10 - Éthanol en tant que produit chimique et non en tant que boisson alcoolique préparé comme sous-produit, ou préparé à partir d'un substrat constitué par des déchets ou par des matières cellulosiques d'un substrat constitué par des matières cellulosiques
49.
METHOD FOR PRODUCING NANOCELLULOSES FROM A CELLULOSE SUBSTRATE
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Cathala, Bernard
Villares, Ana
Berrin, Jean-Guy
Moreau, Céline
Abrégé
The invention concerns a method for producing nanocelluloses from a cellulose substrate comprising cellulose fibres, said method comprising the following sequence of steps: - a step of enzymatic treatment of said cellulose substrate, by bringing same into contact with at least one cleaving enzyme, then - a step of mechanical treatment of said cellulose substrate subjected to said step of enzymatic treatment, in order to delaminate said cellulose fibres and obtain said nanocelluloses, characterised in that said at least one cleaving enzyme is chosen from the enzymes belonging to the family of lytic polysaccharide monooxygenases (LPMOs) capable of achieving cleavage in the presence of an electron donor. The invention also relates to the nanocelluloses obtained according to said method. No figure.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Martinant, Jean-Pierre
Comadran, Jordi
Laffaire, Jean-Baptiste
Rogowsky, Peter
Widiez, Thomas
Abrégé
The present invention concerns an isolated polynucleotide responsible of haploid induction in maize plants and related processes. Additionally, the invention relates to plants that have been genetically transformed with the polynucleotide of the invention. The invention also relates to a process for screening a mutant plant population for enhanced haploid induction by using said isolated polynucleotide. The invention further relates to molecular markers associated with haploid induction in maize plants and their use in quality control for inducer lines.
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
51.
COMPOSITIONS COMPRISING YEAST CELLS AND POLYPHENOLS AND THEIR USE
INSTITUT NATIONAL D'ETUDES SUPÉRIEURES AGRONOMIQUES DE MONTPELLIER (MONTPELLIER SUPAGRO) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
DANSTAR FERMENT AG (Suisse)
Inventeur(s)
Vernhet, Aude
Mekoue Nguela, Julie
Brillouet, Jean-Marc
Sieczkowski, Nathalie
Abrégé
The present disclosure concerns a composition comprising yeast cells and at least one polyphenols having a molecular weight above 620 Da, the polyphenols are adsorbed and retained in the cytoplasm of the yeast cell. The present disclosure also concerns using the composition in cosmetic, dermatological, nutritional and / or pharmaceutical fields, as well as in winemaking to protect the wine against oxidation, therefore preserving the wine quality, color and aromas, and as an alternative to ageing of wine on lees.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Lopez, Michel
Fliss, Myriam
Marion, Didier Gilbert
Abrégé
The invention relates to the use of a cysteine endoprotease or a malt extract for preventing or reducing cloudiness in fermented or non-fermented cereal-based drinks.
A23L 2/84 - Clarification ou affinage des boissons non alcooliséesÉlimination des matières non désirées utilisant des micro-organismes ou un matériau biologique, p. ex. enzymes
C12H 1/00 - Pasteurisation, stérilisation, conservation, purification, clarification ou vieillissement des boissons alcoolisées
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
FONDS DE DÉVELOPPEMENT DES FILIÈRES DES OLÉAGINEUX ET DES PROTEAGINEUX FIDOP (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Thevenieau, France
Nicaud, Jean-Marc
Sauveplane, Vincent
Gamboa-Meléndez, Heber
Morin, Nicolas
Abrégé
The invention relates to the use of a yeast strain overexpressing at least the following genes: the ALK3 gene, at least one of genes ADH2 and ADH5 and at least one of genes FALDH3 and FALDH4, or gene FA01, for the fermentation-based production of carboxylic diacids.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
SYNCHROTRON SOLEIL (France)
Inventeur(s)
Roblin, Pierre
Perez, Javier
Abrégé
The transfer device (10) comprises a sampling needle (24), means (26) of moving the needle (24) between the sample support (12) and the analysis device (14), a selector (28) comprising at least first (28A), second (28B) and third (28C) routes, of which the central route (28A) is connected to the sampling needle (24), the selector (28) being able selectively to connect two routes to one another, a sampling syringe (30), connected to the second route (28B) of the selector (28) and a conveying syringe (32), connected to the third route (28C) of the selector (28) and intended to contain an incompressible liquid.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
55.
NOVEL METHOD FOR DETECTING THE PRESENCE OF BETA-LACTAMASE-PRODUCING BACTERIA
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE DIJON (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Dequaire-Rochelet, Murielle
Hartmann, Alain
Neuwirth, Catherine
Chantemesse, Benoit
Abrégé
The present invention relates to an electrochemical method for determining, in vitro, the presence of beta-lactamase-producing bacteria in a sample that may contain said bacteria.
G01N 27/48 - Systèmes utilisant la polarographie, c.-à-d. la mesure des variations d'intensité sous une tension qui varie lentement
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE (INSAT) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
UNIVERSITE DE BORDEAUX (France)
INSTITUT POLYTECHNIQUE DE BORDEAUX (France)
Inventeur(s)
Andre, Isabelle
Grelier, Stéphane
Guieysse, David
Lafraya, Alvaro
Monsan, Pierre
Moulis, Claire
Peruch, Frédéric
Remaud-Simeon, Magali
Vuillemin, Marlène
Abrégé
The present invention relates to a method for producing a glycosylated synthon or a monomer. Said method includes at least one step of placing at least one glycan-saccharase in the presence of at least one hydroxylated synthon and at least one saccharose. The invention also relates to a method for producing a glyco(co)polymer, including polymerizing at least two monomers separately obtained from the enzymatic glycosylation method according to the invention, and to a method for producing a glyco(co)polymer, preferably a block glyco(co)polymer, including coupling at least two monomers separately obtained from the enzymatic glycosylation method according to the invention.
C12P 19/44 - Préparation d'O-glucosides, p. ex. glucosides
C12P 19/58 - Préparation d'O-glucosides, p. ex. glucosides avec un atome d'oxygène du radical saccharide lié directement, uniquement par des atomes de carbone acycliques, à un hétérocycle autre que saccharide, p. ex. bléomycine, phléomycine
C12P 19/60 - Préparation d'O-glucosides, p. ex. glucosides avec un atome d'oxygène du radical saccharide lié directement à un hétérocycle autre que saccharide ou à un système cyclique condensé contenant un hétérocycle autre que saccharide, p. ex. coumermycine, novobiocine
C08F 120/28 - Esters contenant de l'oxygène en plus de l'oxygène de la fonction carboxyle ne contenant pas de cycles aromatiques dans la partie alcool
C08F 120/58 - Amides contenant de l'oxygène en plus de l'oxygène de la fonction carbonamide
57.
METHOD FOR MANUFACTURING A CHEESE-BASED FOOD PRODUCT, ADVANTAGEOUSLY A CHEESE, CHEESE SPECIALTY, OR CHEESE SUBSTITUTE
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
INSTITUT SUPERIEUR DES SCIENCES AGRONOMIQUES, AGROALIMENTAIRES, HORTICOLES ET DU PAYSAGE (France)
Inventeur(s)
Garric, Gilles
Leonil, Joëlle
Jeantet, Romain
Gaucheron, Frédéric
Schuck, Pierre
Lortal, Sylvie
Abrégé
The present invention relates to a method for manufacturing a cheese-based food product, advantageously a cheese, cheese specialty, or cheese substitute. Said manufacturing method is characterized in that it includes the following consecutive steps: a) a step A) of providing at least one flavoring matrix, the consistency of which ranges from liquid to pasty, said flavoring matrix resulting from a step of cultivating at least one flavor producing microorganism in a culture medium, said step A) also providing a texture matrix, the consistency of which ranges from liquid to pasty, said texture matrix being suitable for providing the texture of said food product; then b) a step B) of mixing said at least one flavoring matrix with said at least one texture matrix; then c) a texturing step C), during which the mixture from mixing step B is subjected to physiochemical texturing conditions that are adjusted according to the final texture sought for said cheese-based food product.
CENTRE DE COOPÉRATION INTERNATIONAL EN RECHERCHE AGRONOMIQUE POUR LE DÉVELOPPEMENT (CIRAD) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
TERRES INOVIA (France)
AVRIL (France)
Inventeur(s)
Aouf, Chahinez
Zago, Erika
Lecomte, Jérôme
Villeneuve, Pierre
Fulcrand, Hélène
Fine, Frédéric
Rous, Jean-François
Abrégé
The invention relates to a compound having the following Formula (I), wherein n and m are whole numbers from 0 to 6, selected independently from each other, and R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, selected independently from each other, and are each a hydrogen atom, an -OH group, or a group selected among: - straight, branched, or cyclic C1-C6 alkyl radicals; - straight, branched, or cyclic C2-C6 alkenyl radicals, optionally interrupted by one or more heteroatoms such as O or N and/or substituted by one or more -OH groups; and - ether oxide radicals having 0 to 6 saturated or unsaturated, straight, branched, or cyclic carbon atoms, optionally interrupted by one or more heteroatoms such as O, Si, or N and/or substituted by one or more -OH groups. In Formula (I), at least one R1 through R5 group is an O-methyl oxirane, at least one R6 through R10 group is an O-methyl oxirane, and at least one of the radicals R2, R4, R7, and R9 is an O-methyl. The invention also relates to a preparation method and to uses of the Formula (I) compound.
C07D 303/23 - Éthers oxiranylméthyliques de composés comportant un groupe hydroxy lié à un cycle aromatique à six chaînons, le radical oxiranylméthylique ne comportant pas d'autre substituant, c.-à-d.
A23L 35/00 - Aliments ou produits alimentaires non prévus par les groupes Leur préparation ou leur traitement
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/336 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à trois chaînons, p. ex. oxirane, fumagilline
C07D 303/28 - Éthers avec des composés hydroxylés contenant des cycles oxirane
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Aouf, Chahinez
Mayer, Claire
Barakat, Abdellatif
Hoh, Hélène
Abrégé
The invention relates to a process for obtaining a conifer bark-base composition enriched with dihydroquercetin or with tannins, comprising the following steps: a) grinding dried shavings of bark from a conifer so as to obtain a ground conifer bark particle material, and b) selecting, from the ground particle material obtained in step a), the fraction of particles:- of smallest size representing at most 40% by weight, relative to the total weight of the ground particle material obtained in step a), this fraction being enriched with tannins; or - of largest size representing at most 50% by weight, relative to the total weight of the ground particle material obtained in step a), this fraction being enriched with dihydroquercetin.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
CENTRE INTERNATIONAL D’ÉTUDES SUPÉRIEURES EN SCIENCES AGRONOMIQUES (France)
Inventeur(s)
Abecassis, Joël
Laleg, Karima
Cassan, Denis
Micard, Valérie
Abrégé
The invention relates to a process for obtaining an extruded or laminated dough intended for food for human consumption and/or animal feed, comprising at least the following steps: a) hydrating a flour and/or a semolina, or a mixture of flours and/or semolinas, comprising at least 35% by weight of leguminous plant or of a mixture of leguminous plants, relative to the total dry weight of said flour and/or semolina, or said mixture of flours and/or semolinas, at a temperature below ambient temperature, preferably at a temperature below 15°C, so as to obtain a hydrated flour and/or semolina or a hydrated mixture of flours and/or semolinas; b) kneading the hydrated flour and/or semolina, or the hydrated mixture of flours and/or semolinas, obtained in step a), at a temperature below ambient temperature, preferably at a temperature below 15°C, so as to obtain a kneaded material; and c) extruding or laminating the kneaded material obtained in step b) at a temperature below 55°C, preferably at a temperature between 35°C and 45°C, so as to obtain an extrudate, or preferably at a temperature between 28°C and 30°C, so as to obtain a laminated dough, said process being carried out under conditions appropriate for reducing and/or inhibiting enzymatic reactions, preferably oxidation enzymatic reactions, and non-enzymatic reactions, preferably free-radical non-enzymatic reactions.
A23K 10/30 - Produits alimentaires pour animaux à base de matières d’origine végétale, p. ex. de racines, de graines ou de foinProduits alimentaires pour animaux à base de matières d’origine fongique, p. ex. de champignons
A23P 20/20 - Fabrication de produits alimentaires feuilletés, multicouches, fourrés ou à corps creux, p. ex. par enveloppement dans des feuilles de pâte comestible préformée ou dans des récipients alimentaires comestibles
A23L 11/00 - Légumes secs, c.-à-d. fruits de plantes légumineuses, pour l'obtention d'alimentsProduits dérivés de légumineusesLeur préparation ou leur traitement
A23L 11/30 - Élimination des substances indésirables, p. ex. des substances amères
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (France)
INSTITUT SCIENCES INDUSTRIES VIVANT ET ENVIRONNEMENT (France)
Inventeur(s)
Dubreucq, Bertrand
Miquel, Martine
Faure, Jean-Denis
Bellec, Yannick
Abrégé
The invention relates to an extraction device comprising an extraction body (14) having a cylinder (30) and a compression piston (32) movable in the cylinder (30), the cylinder (30) and the piston (32) together defining a chamber (34) for receiving the substance, and the cylinder (30) comprising at least one liquid outflow opening ending in said receiving chamber (34). The cylinder (30) extends in a compression direction (C), and the compression piston (32) is arranged such that it slides freely along said compression direction (C) in said cylinder (30).
B30B 9/04 - Presses spécialement adaptées à des fins particulières pour exprimer les liquides des substances les contenant, p. ex. le jus des fruits, les huiles des oléagineux utilisant des pilons de presse
B04B 3/02 - Centrifugeurs à tambours rotatifs dans lesquels les particules ou les corps solides sont séparés par la force centrifuge et simultanément par tamisage ou filtration évacuant du tambour les particules solides grâce à des moyens coaxiaux à l'axe du tambour et animés d'un mouvement longitudinal alternatif, c.-à-d. centrifugeurs à tiroir
B04B 5/10 - Centrifugeurs combinés avec d'autres appareils, p. ex. avec des séparateurs électrostatiquesEnsembles ou systèmes de plusieurs centrifugeurs
B04B 5/04 - Appareils à chambre radiale pour séparer des mélanges essentiellement liquides, p. ex. butyromètres
62.
PROCESS FOR PRODUCING AT LEAST ONE METABOLITE OF INTEREST BY CONVERSION OF A PENTOSE IN A MICROORGANISM
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
INSTITUT NATIONAL DES SCIENCES APPLIQUEES - INSA (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Walther, Thomas
Cam, Yvan
Francois, Jean-Marie
Alkim, Ceren
Abrégé
The invention relates to a process for producing at least one metabolite of interest by conversion of a pentose in a microorganism, characterized in that said process comprises at least: (i) an operation of culturing a recombinant microorganism expressing a synthetic pathway for pentose assimilation which comprises at least the following steps: a) phosphorylation in position 1 of a pentose chosen from (D)-xylulose and/or (L)-ribulose, b) cleavage of the pentose-1-phosphate obtained at the end of step a), in order to obtain glycolaldehyde and dihydroxyacetone phosphate (DHAP), and (ii) an operation of recovering said at least one metabolite of interest obtained at the end of the culturing operation (i). The invention also relates to an associated microorganism.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) (France)
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP) (France)
ECOLE D'INGENIEURS DE PURPAN (France)
Inventeur(s)
Langella, Philippe
Miquel, Sylvie
Martin Rosique, Rebeca
Bermudez Humaran, Luis
Thomas, Muriel
Sokol, Harry
Carvalho, Frédéric
Theodorou, Vassilia
Abrégé
The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (France)
UNIVERSITE PARIS-SUD (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Zitvogel, Laurence
Vetizou, Marie
Lepage, Patricia
Abrégé
The present invention relates to the role of the microbiota in the efficacy of cancer treatments with a drug blocking an. immune checkpoint and provides methods and probiotics to improve the efficacy of such a treatment in patients in need thereof. More particularly, the invention pertains to the use of vancomycin or penicillin to modulate the gut microbiota to potentiate the anticancer effects of anti-CTLA4 molecules. B. fragilis or fecal microbial transplantation of a defined composition enriched in immunogenic Bacteroides spp. can also be used as a probiotic to that aim.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
SAPHINOV S.N.C. (France)
Inventeur(s)
Kapustra, Véronique
Abrégé
Abelia plant named, ‘ABENOV41’ that is characterized by its an evergreen plant habit in U.S.D.A. Zone 7, its long and floriferous bloom period, blooming from May to October in France, its large flowers that are pink-violet in color and open from deep pink-purple buds, its bracts that are reddish brown in color, and its moderate to vigorous growth habit.
A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
66.
METHOD AND DEVICE FOR STIMULATING MYELINATED AND UNMYELINATED SMALL DIAMETER VAGAL NEURONS
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Malbert, Charles-Henri
Divoux, Jean-Louis
Guiraud, David
Andreu, David
Abrégé
A method for stimulating vagal neurons as demonstrated by generation of action potentials on these same neurons, wherein electrical pulse trains are periodically applied to electrodes implanted on the anterior and posterior vagus nerve at an entrance of a diaphragm, wherein each electrical pulse train is formed by a plurality of monophasic pulses having a frequency of at least 13.0 kHz.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
67.
METHOD AND DEVICE FOR STIMULATING MYELINATED AND UNMYELINATED SMALL DIAMETER VAGAL NEURONS
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Malbert, Charles-Henri
Divoux, Jean-Louis
Guiraud, David
Andreu, David
Abrégé
A method for stimulating vagal neurons as demonstrated by generation of action potentials on these same neurons, wherein electrical pulse trains are periodically applied to electrodes implanted on the anterior and posterior vagus nerve at an entrance of a diaphragm, wherein each electrical pulse train is formed by a plurality of monophasic pulses having a frequency of at least 13.0 k Hz.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Maurel, Marie-Christine
Reiter, Eric
Gegot, Gwenhael
Durand, Guillaume
Kara, Elodie
Casteret, Sophie
Poupon, Anne
Abrégé
The present invention relates to an antibody against the follicle-stimulating hormone (FSH), said antibody being capable of potentializing FSH and CG bioactivity.
A61P 5/06 - Médicaments pour le traitement des troubles du système endocrinien des hormones de l'hypophyse antérieure, p. ex. TSH, ACTH, FSH, LH, PRL, GH
A61P 5/24 - Médicaments pour le traitement des troubles du système endocrinien des hormones sexuelles
A61P 15/08 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les troubles gonadiques ou pour augmenter la fertilité, p. ex. inducteurs d'ovulation ou de spermatogénèse
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INSTITUT SUPERIEUR DES SCIENCES AGRONOMIQUES, AGROALIMENTAIRES, HORTICOLES ET DU PAYSAGE (AGROCAMPUS OUEST) (France)
VOMM (Italie)
Inventeur(s)
Schuck, Pierre
Dolivet, Anne
Sai, Gaëlle
Mejean, Serge
Jeantet, Romain
Vezzani, Massimo
Abrégé
The present invention relates to a method for preparing a lactose-containing powder. Said method includes the consecutive steps of: a) concentrating a lactose-containing liquid so as to obtain a concentrated liquid having 55% to 65% dry matter content, said concentration Step a) having a duration between 10 and 20 minutes; b) overconcentrating the concentrate obtained from Step a) so as to obtain an overconcentrated material having 75% to 80% dry matter content, said overconcentration Step b) having a duration varying from 2 to 10 minutes; c) granulating the overconcentrate obtained from Step b) by mixing said overconcentrate with a lactose-containing powder, having at least 95% dry matter content, until a granulated powder having dry matter content with at least 85% dry extract is obtained; and d) drying the granulated powder obtained from Step c) so as to obtain a lactose-containing powder having at least 95% dry matter content.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INSTITUT PASTEUR DE LILLE (IPL) (France)
Inventeur(s)
Jan, Gwenael
Foligne, Benoit
Falentin, Hélène
Deutsch, Stéphanie-Marie
Abrégé
The present invention relates to a polypeptide comprising or consisting of the amino acid sequence SEQ id n°:1, for use in the treatment or prevention of an inflammatory disease. The invention further encompasses a nucleic acid sequence encoding a polypeptide of the invention, a vector comprising a nucleic acid of the invention and a host cell comprising a nucleic acid sequence and/or a vector of the invention, for use in the treatment or prevention of an inflammatory disease. The invention also concerns a pharmaceutical composition or a food composition comprising a polypeptide, a nucleic acid sequence, a vector or a host cell of the invention and a pharmaceutically acceptable carrier or a dairy product, for the treatment of inflammatory disease. The invention also relates a method for the screening of bacteria having immunomodulatory properties.
A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
71.
PORTABLE DEVICE FOR DETECTING THE PRESENCE OF ELEMENTS HAVING AN ICE PRODUCING ACTIVITY IN AT LEAST ONE SAMPLE
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Morris, Cindy E.
Bastien, Jean-Marc
Abrégé
The present invention relates to a portable device for detecting the presence of elements having an ice producing activity, in at least one sample (E). The portable device (1) has a refrigeration unit (2) comprising - a thermally insulated chamber (3) having at least two locations (8) which are each suitable for receiving a receptacle (M) containing one of said samples (E), - means (4) for refrigeration of said chamber (3), - means (5) for measurement of the temperature, - means (6) for regulation of a target temperature within said chamber (3), - means (7) for autonomous electrical power supply of said refrigeration unit (2), - and means (6) for signalling the attainment of said target temperature. According to the invention, said locations (8) each have dimensions suitable, allowing for clearance, for receiving said receptacle (M) consisting of a microtube (M).
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Martin, Christophe
Robert, Denis
Feron, Gilles
Abrégé
The present invention concerns a device (1) for evaluating the orosensory perception of a subject. Said evaluation device (1) comprises a body (2) made from an edible material and comprising at least one detachable part (3) which comprises at least one compound of interest that is likely to constitute an orosensory stimulus, and is designed to be separated from a residual part (21) of said body (2) in order to be deposited in the oral cavity of said subject. Said detachable part or parts (3) are arranged in said body (2), forming a monobloc assembly, and are each delimited by a peripheral edge (31), at least a portion of which is rigidly connected to a residual part (21) of the body (2) by a weakened line (32) preferably consisting of a precut line.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
B65D 75/30 - Objets ou matériaux enveloppés entre deux feuilles ou flans opposés à bords réunis, p. ex. par adhésifs à pression, pliage, thermosoudage ou soudage
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
UNIVERSITÉ PAUL SABATIER TOULOUSE III (France)
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (France)
Inventeur(s)
Oswald, Eric
Martin, Patricia
Murase, Kazunori
Abrégé
The present invention relates to ex vivo method for producing outer membrane vesicles (OMVs) by expression or overexpression of the hemolysin F gene (hlyF) in gram-negative bacterium.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
CNAM - CONSERVATOIRE NATIONAL DES ARTS ET MÉTIERS (France)
INSTITUT SCIENCES INDUSTRIES VIVANT ET ENVIRONNEMENT (France)
BRODART (France)
INSTITUT DES CORPS GRAS (France)
Inventeur(s)
Ducruet, Violette
Ruellan, Alexandre
Aichernig-Domenek, Sandra
Guinault, Alain
Sollogoub, Cyrille
Alfos, Carine
Chollet, Guillaume
Delamour, Anne-Chrystelle
Abrégé
The present invention relates to the use of a composition comprising at least one saturated free fatty acid and at least one unsaturated free fatty acid as additive, for modifying the mechanical properties of a thermoplastic polymer material. The present invention also relates to an additivated thermoplastic polymer material and to the process for producing same.
C08L 27/06 - Homopolymères ou copolymères du chlorure de vinyle
C08L 67/00 - Compositions contenant des polyesters obtenus par des réactions créant une liaison ester carboxylique dans la chaîne principaleCompositions contenant des dérivés de tels polymères
C08L 77/00 - Compositions contenant des polyamides obtenus par des réactions créant une liaison amide carboxylique dans la chaîne principaleCompositions contenant des dérivés de tels polymères
75.
METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF INFLUENZA A VIRUS INFECTION
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
UNIVERSITÉ CLAUDE BERNARD - LYON 1 (France)
UNIVERSITÉ PARIS XIII PARIS-NORD (France)
UNIVERSITÉ PARIS DIDEROT - PARIS 7 (France)
Inventeur(s)
Riteau, Béatrice
Jandrot-Perrus, Martine
Le, Ba Vuong
Abrégé
The present invention relates to methods and pharmaceutical compositions for the treatment of influenza A virus infection. In particular, the present invention relates to a method for the treatment of influenza A virus (IAV) infection in a subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one anti-platelet agent.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61K 31/416 - 1,2-Diazoles condensés avec des systèmes carbocycliques, p. ex. indazole
A61K 31/4365 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique ayant le soufre comme hétéro-atome du cycle, p. ex. ticlopidine
A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p. ex. adénosine, acide adénylique
A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Poessel, Jean-Luc
Sauge-Collet, Marie-Hélène
Rahbe, Yvan
Abrégé
The use of a polyhydroxylated polyaromatic compound, in particular of chicoric acid, for combating plant pests and phytosanitary composition comprising chicoric acid.
A01N 37/38 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant au moins un groupe carboxylique ou un thio-analogue, ou d'un de leurs dérivés, et un atome d'oxygène ou de soufre lié par une liaison simple, liés au même squelette carboné, cet atome d'oxygène ou de soufre ne faisant pas partie d'un groupe carboxylique ou d'un thio-analogue, ou d'une de leurs dérivés, p. ex. acides hydroxycarboxyliques contenant au moins un atome d'oxygène ou de soufre lié à un système cyclique aromatique
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
UNIVERSITÉ PARIS DIDEROT - PARIS 7 (France)
UNIVERSITÉ PARIS XIII PARIS-NORD (France)
HOSPICES CIVILS DE LYON (France)
CENTRE HOSPITALIER INTERCOMMUNAL TOULON-LA SEYNE-SUR-MER (France)
Inventeur(s)
Pelle, Anne
Chaunier, Laurent
Lourdin, Denis
Bizeau, Alain
Faure, Frédéric
Abrégé
The present invention relates to starch-based stents for use in the treatment of duct obstruction. In particular, the present invention relates to a method for treating a duct obstruction in a subject in need thereof comprising the step of i) removing the duct obstruction of the subject and ii) implanting a starch based stent for maintaining the open duct.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Tilloy, Valentin
Ortiz-Julien, Anne
Noble, Jessica
Dequin, Sylvie
Abrégé
The present disclosure concerns a process for obtaining a variant yeast strain capable of producing less ethanol in an alcoholic fermentation process than its corresponding ancestral strain. The variant yeast strain is obtained by culturing the ancestral strain in the presence of increasing concentrations of a salt capable of causing an hyperosmotic stress to the ancestral yeast strain. The present disclosure also concerns variant yeast strain obtained from this process (for example the variant yeast strain deposited at Institut Pasteur, on January 9, 2014, under accession number CNCM I-4832, the variant yeast strain deposited at Institut Pasteur, on October 18, 2012 under accession number CNCM I-4684, the variant yeast strain deposited at Institut Pasteur, on October 18, 2012 under accession number CNCM I-4685 and/or the variant yeast strain deposited at Institut Pasteur on January 28, 2015 under accession number CNCM I-4952) as well as processes using the variant yeast strain (wine fermentation for example).
C12P 1/02 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des champignons
C12G 1/022 - FermentationTraitement microbiologique ou enzymatique
79.
PROCESS FOR TREATING EFFLUENTS LOADED WITH AMMONIACAL NITROGEN, AND REACTOR FOR THE IMPLEMENTATION OF THE PROCESS
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Peregrina, Carlos
Renvoise, Laure
Bernet, Nicolas
Trably, Eric
Abrégé
Process for treating effluents loaded with ammoniacal nitrogen in a single-chamber reactor (R), to remove the ammoniacal nitrogen therefrom, according to which: provided in the reactor is an anode (A) on which a biofilm essentially containing autotrophic bacteria is formed, and a cathode (C), then completely anaerobic conditions are established in the reactor; a volume of effluent to be treated is introduced into the reactor; a potential difference is applied and maintained between the anode and the cathode throughout the duration of the treatment for eliminating the ammoniacal nitrogen.
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Berteau, Olivier
Nicolet, Yvain
Fontecilla-Camps, Juan
Benjdia, Alhosna
Guillot, Alain
Abrégé
The present invention relates to a new enzyme able to produce 4-hydroxybenzyl alcohol from the amino acid tyrosine and the use thereof for producing 4-hydroxybenzyl alcohol.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
ECOLE NORMALE SUPERIEURE DE LYON (France)
Inventeur(s)
Perrard, Marie-Hélène
Durand, Philippe
David, Laurent
Abrégé
The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Kascakova, Slavka
Refregiers, Matthieu
Giuliani, Alexandre
Abrégé
The present invention relates to a radioluminescent compound for radiotherapy and deep photodynamic therapy (Deep PDT), the radioluminescent compound comprising a molecular conjugate made up of a radioluminescent molecule and one photosensitiser, the radioluminescent molecule being suitable for absorbing an X-ray with energy higher than an absorption threshold and for emitting luminescent radiation in the visible domain, and the photosensitiser being suitable for absorbing said luminescent radiation and producing singlet oxygen. According to the invention, the radioluminescent compound is made up of a molecule of lanthanide chlorine (LnCl3); said photosensitiser is selected among the following photosensitisers: Al(III)phthalocyanine, m-THPC, chlorin e6 (Ce6), hypericin, hypocrellin, Nile blue, oxazine 170, oxazine 1, protoporphyrin IX, 7-methoxycoumarin-4-acetic acid, bacteriochlorophyll, and auramine; and said photosensitiser is selected such as to maximise the energy transfer between an X-ray absorbed by the radioluminescent lanthanide 2 and the photosensitiser in order to produce singlet oxygen.
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE (France)
UNIVERSITÉ PAUL SABATIER TOULOUSE III (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
Oswald, Eric
Martin, Patricia
Abrégé
The present invention relates to a method for the screening of substances that may be useful for the prevention and treatment of infections by Enterobacteriaceae family comprising a step of determining the ability of a candidate substance to inhibit the expression of the gene entD and/or clbA of the Enterobacteriaceae or to inhibit the activity of the protein encoded by the gene entD and/or the gene clbA.
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
A61K 38/00 - Préparations médicinales contenant des peptides
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Giuliani, Alexandre
Abrégé
The present invention concerns a system and method of mass spectrometry, comprising the following steps: a. ionising an analyte to form a precursor ion (A) having a mass-to-charge ratio (m/z), in which m represents the mass and z the atomic number; b. activating the precursor ion (A) by interaction with a beam of neutral species, ions, electrons or photons, having an energy chosen on the basis of the physicochemical properties of the precursor ion, said activation being suitable for producing a product ion (B, C) having the same mass m as said precursor ion (A) and an atomic number z' such that z' is a non-zero integer different from z, z' preferably being chosen from z+1, z+2, z+3, z-1, z-2, z-3, the product ion being formed by ionisation, electron detachment, electron capture or transfer without fragmentation; c. separating the product ion (B, C, E, F) having a predefined mass-to-charge ratio (m/z'); d. detecting said product ion (B, C) having the predefined mass-to-charge ratio (m/z').
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
85.
POLYPEPTIDE HAVING THE CAPACITY TO FORM ALPHA-1,3 GLUCOSYL UNIT BRANCHINGS ON AN ACCEPTOR
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
Remaud-Simeon, Magali
Vuillemin, Marlène
Moulis, Claire
Monsan, Pierre
Morel, Sandrine
Abrégé
The present invention relates to an isolated polypeptide having the capacity to specifically form alpha-1,3 glucosyl unit branchings on an acceptor comprising at least one hydroxyl group and characterized in that said polypeptide comprises i) the motif I of sequence SEQ ID No. 1, ii) the motif II of sequence SEQ ID No. 2, iii) the motif III of sequence SEQ ID NO. 3, iv) the motif IV of sequence SEQ ID No. 4 or derivatives of one or more of said domains, wherein said polypeptide also exhibits the aspartic residue (D) in position 5 of the motif II (SEQ ID No. 2), the glutamic residue (E) in position 6 of the motif III (SEQ ID No. 3) and the aspartic residue (D) in position 6 of the motif IV (SEQ ID No. 4); and to the uses thereof.
INRIA INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Harmand, Jérôme
Rapaport, Alain
Rousseau, Antoine
Abrégé
Method for treating a fluid resource (1) using a system comprising p output pump(s) (P 1, P 2), a treatment unit (2) and q input pump (s) (Ρ,, P 2, P 3) comprising: • i/ collecting current concentrations of a component near the output pumps; • ii/ a target flow rate for receipt of fluid by the treatment unit is determined as a function of the collected concentrations and of a treatment unit operating law that connects the rate of treatment of the fluid in the treatment unit and the concentration of the component in the fluid at the outlet of the treatment unit; • iii/ a target pumping flow rate for each output pump is determined as a function of the concentration of said component near said output pump and is transmitted to said output pump; and • iv/ each output pump implements the transmitted target pumping flow rate, the treatment unit implementing the determined target flow rate for receipt of the fluid. A computer program in a processing module (4) and a module for determining pumping flow rate values are also claimed.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Leotoing, Laurent
Coxam, Véronique
Wittrant, Yohann
Abrégé
The invention relates to a combination including at least (i) fisetin or one of the derivatives thereof, and (ii) docosahexaenoic acid (DHA) or one of the derivatives thereof, to be used for the treatment and/or prevention of disorders associated with bone loss and/or with an imbalance in the ratio of bone formation to resorption. The invention also relates to a composition including said combination for the use thereof as previously described.
A61K 31/202 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique ayant au moins trois doubles liaisons, p. ex. acide linolénique
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
A61P 19/08 - Médicaments pour le traitement des troubles du squelette des maladies osseuses, p. ex. rachitisme, maladie de Paget
A61P 19/10 - Médicaments pour le traitement des troubles du squelette des maladies osseuses, p. ex. rachitisme, maladie de Paget de l'ostéoporose
A23L 1/00 - Aliments ou produits alimentaires; Leur préparation ou traitement (leur conservation en général A23L 3/00)
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
UNIVERSITÉ DE MONTPELLIER 2 (France)
Inventeur(s)
Charnet, Pierre
Cens, Thierry
Rousset, Matthieu
Collet, Claude
Abrégé
The present invention relates to a calcium channel isolated from bees, comprising a Cavα channel having a sequence chosen from the group comprising the sequences SEQ ID Nos 1 to 3. The present invention also relates to a calcium channel isolated from bees, comprising a Cavα channel, a Cavα2‑δ regulatory protein having a sequence chosen from the group comprising the sequence SEQ ID Nos 6 to 8 and/or a Cavβ regulatory protein having a sequence chosen from the group comprising the sequences SEQ ID Nos 4, 5 and 107. The present invention also relates to nucleic acid sequences and to vectors comprising these coding sequences, and also to a method for producing these calcium channels and to the uses thereof. The present invention is in particular of use in the agricultural, ecological and chemistry fields and in the beekeeping field. In particular, it is of use for the analysis/identification of the toxicity or of the innocuousness of molecules, for example of chemical molecules, with respect to bees.
INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE (INPT) (France)
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Bergez-Lacoste, Manon
De Caro, Pascale
Thiebaud-Roux, Sophie
Fabre, Jean-François
Mouloungui, Zéphirin
Balastre, Marc
Marion, Philippe
Abrégé
The present invention concerns the use of a furfural derivative of formula (I) in which R represents (i) a -CH=CR'1-COR1 group, a group (ii), a group (iii), a group (iv) or a -CHO group and R' represents a hydrogen atom or a (C1-C4)alkyl group, as a chemical vehicle, as a solvent, co-solvent, coalescing agent, crystallisation inhibitor, plasticising agent, degreasing agent, etchant, cleaning agent or agent for increasing biological activity, and more particularly as a solvent. It also concerns phytosanitary formulations or resin-solubilising formulations comprising at least one such furfural derivative of formula (I).
C07D 307/46 - Atomes d'oxygène liés par des liaisons doubles ou deux atomes d'oxygène liés par des liaisons simples au même atome de carbone
C07D 307/52 - Radicaux substitués par des atomes d'azote ne faisant par partie d'un radical nitro
C07D 307/54 - Radicaux substitués par des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile
C07D 307/56 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle
A01N 25/02 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles contenant des liquides comme supports, diluants ou solvants
A01N 51/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant les séquences d'atomes O—N—S, X—O—S, N—N—S, O—N—N ou O-halogène, sans considération du nombre de liaisons de chaque atome, aucun atome de ces séquences ne faisant partie d'un hétérocycle
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Denery, Sandra
Tranquet, Olivier
Larre, Colette
Abrégé
The present invention relates to a monoclonal antibody that is capable of bonding to deamidated gluten proteins and has no cross-reaction with the non-deamidated gluten proteins.
G01N 33/577 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet faisant intervenir des anticorps monoclonaux
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Langella Philippe
Pigneur-Arnaud, Bénédicte
Chatel, Jean-Marc
Quevrain, Elodie
Seksik, Philippe
Trugnan, Germain
Chain, Florian
Bermudez-Humaran, Luis G.
Maubert, Marie-Anne
Michon, Christophe
Sokol, Harry
Abrégé
The present invention relates to a polypeptide comprising or consisting of the amino acid sequence SEQ ID NO: l, for use in the treatment or prevention of an inflammatory disease. The invention further encompasses a nucleic acid sequence encoding a polypeptide of the invention, a vector comprising a nucleic acid of the invention and a host cell comprising a nucleic acid sequence and/or a vector of the invention, for use in the treatment or prevention of an inflammatory disease. The invention also concerns a pharmaceutical composition comprising a polypeptide, a nucleic acid sequence, a vector or a host cell of the invention and a pharmaceutically acceptable carrier, for the treatment of inflammatory disease.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA (France)
ECOLE NATIONALE SUPERIEURE DES SCIENCES AGRONOMIQUES DE BORDEAUX AQUITAINE (BORDEAUX SCIENCES AGRO) (France)
Inventeur(s)
Khuong Huu, Marie
Fioramonti, Jean
Urdaci, Maria
Abrégé
The present invention pertains to a method of selecting or identifying probiotic strains capable of altering water absorption in the colon, and the use of same as medications in the treatment and/or prevention of diarrhœa. The invention particularly relates to the strain Bacillus subtilis CUl for its use in the treatment and/or prevention of diarrhœa.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
TOULOUSAINE DES FARINES (France)
ARTERRIS INNOVATION (France)
Inventeur(s)
Abecassis, Joël
Bernabe, Antoine
Chaurand, Marc
Chiron, Hubert
Duboin, Guillaume
Pellerin, Philippe
Abrégé
The invention relates to durum wheat flour wherein the particle size (D90) of at least 90 % of the grains is smaller than 200 µm and wherein the damaged starch content is higher than 8 %.
A21D 10/02 - Pâtes du type "prêt à cuire", p. ex. pâtes emballées
A23L 1/10 - contenant des produits dérivés des céréales
94.
PROCESS FOR THE PRODUCTION OF A POWDERED DRY EMULSION CONTAINING AT LEAST ONE LIPOPHILIC ACTIVE INGREDIENT, INTENDED FOR IMPROVING THE BIOAVAILABILITY OF SAID LIPOPHILIC ACTIVE INGREDIENT, AND DRY EMULSION OBTAINED BY THIS PROCESS
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Anton, Marc
Genot, Claude
Castellani, Oscar
Bretillon, Lionel
Chardigny, Jean-Michel
Abrégé
The present invention relates to a process for the production of a powdered dry emulsion containing at least one lipophilic active ingredient, intended for improving the bioavailability of said lipophilic active ingredient, which comprises the following steps: (a) a step of providing an aqueous phase containing at least one emulsifying compound which is protein in nature, chosen from whey proteins, and a lipid phase containing said lipophilic active ingredient(s), (b) a step of forming an oil-in-water emulsion, (c) a step of incorporating at least one saccharide compound into said oil-in-water emulsion resulting from step (b), and (d) a step of eliminating said aqueous phase in order to obtain said powdered dry emulsion.
A23D 9/05 - Obtention de produits à écoulement libre
A23D 7/005 - Compositions à base d'huiles ou de graisses comestibles contenant une phase aqueuse, p. ex. margarines caractérisées par des ingrédients autres que des triglycérides d'acides gras
A23D 9/007 - Autres huiles ou graisses comestibles, p. ex. huiles pour cuisson caractérisées par des ingrédients autres que des triglycérides d'acides gras
A23L 1/30 - contenant des additifs (A23L 1/308 a priorité);;
A61K 8/36 - Acides carboxyliquesLeurs sels ou anhydrides
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
Inventeur(s)
Lagella, Philippe
Bermudez Humaran, Luis G.
Chain, Florian
Kechaou, Nora
Chatel, Jean-Marc
Abrégé
The present invention relates to the field of probiotics. More particularly, the present invention relates to a probiotic Lactobacillus plantarum bacterial strain which has a positive effect on the immune system, both in terms of innate immunity and in terms of adaptive immunity. This effect is manifested in particular in the case of influenza. Even more surprisingly, this bacterial strain exhibits resistance to bile salts, which are a stress inherent in the human digestive tract and in particular in the intestines. The present invention also relates to uses of said bacterial strain. Moreover, the present invention relates to a composition containing said strain.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
Inventeur(s)
Capron, Isabelle
Bizot, Hervé
Cathala, Bernard
Abrégé
The invention relates to a composition, advantageously an emulsion or a foam, comprising an internal phase dispersed in a hydrophilic continuous phase, the percentage of the internal phase being higher than 50%. Said emulsion composition contains nanocrystals of a polysaccharide other than cellulose, advantageously chitin, that are located at the interface between said internal phase and said hydrophilic continuous phase.
C08J 9/28 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par élimination d'une phase liquide d'un objet ou d'une composition macromoléculaire, p. ex. par séchage du coagulum
C08J 9/30 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par mélange de gaz dans des compositions liquides ou des plastisols, p. ex. par fabrication de mousse à l'aide d'air
B01F 17/00 - Utilisation de substances comme agents émulsifiants, humidifiants, dispersants ou générateurs de mousse
97.
COMBINATION PRODUCT FOR TREATING EXCESS WEIGHT AND/OR FOR IMPROVING THE FIGURE
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA (France)
UNIVERSITE PARIS DESCARTES (France)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (France)
Inventeur(s)
Morio-Liondore, Béatrice
Capel, Frédéric
De Bandt, Jean-Pascal
Moinard, Christophe
Cynober, Luc
Abrégé
The invention relates to a combination product including, as active substances, at least one inhibitor of the HMG-CoA reductase enzyme and citrulline or a compound that is the bioequivalent thereof, for treating excess weight or obesity and/or the accumulation of body fat. The invention also relates to a cosmetic treatment method for improving or slimming the figure and/or stimulating the loss of excess weight and/or cellulite and/or reducing the accumulation thereof, said method including administering a combination product that includes, as active substances, at least one inhibitor of the HMG-CoA reductase enzyme or a physiologically acceptable salt thereof, and citrulline or a compound that is the bioequivalent thereof, or one of the analogs thereof, and repeating said administration until the desired cosmetic effect has been achieved. Finally, the invention relates to the use of a combination product as defined above for improving or slimming the figure and/or stimulating the loss of excess weight and/or cellulite and/or reducing the accumulation thereof.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61K 31/045 - Composés hydroxylés, p. ex. alcoolsLeurs sels, p. ex. alcoolates
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 31/366 - Lactones ayant des cycles à six chaînons, p. ex. delta-lactones
A61K 31/402 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil substitués par un groupe aryle en position 1, p. ex. pirétanide
A61K 31/473 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. acridines, phénantridines
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 8/02 - Cosmétiques ou préparations similaires pour la toilette caractérisés par une forme physique particulière
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
UNIVERSITÉ DE STRASBOURG (France)
Inventeur(s)
Baron, Olga
Reichhart, Jean-Marc
Ponchet, Michel
Coustau, Christine
Abrégé
The present invention relates to the use of LBP/BPI polypeptide to prevent and/or treat diseases caused by oomycetes. The present invention also relates to compositions containing LBP/BPI polypeptides to prevent and/or treat diseases caused by oomycetes. The present invention further relates to the preparation of transgenic plants and animals expressing the LBP/BPI polypeptide of the invention. The present invention finally relates to a method for producing the LBP/BPI polypeptide of the invention.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
VILMORIN ET CIE (France)
Inventeur(s)
Bendahmane, Abdelhafid
Troadec, Christelle
Boualem, Adnane
Hosemans, Danièle
Fauve, Julie
Abrégé
The present invention relates to plants of the Cucurbit family and seeds of such plants having an androecious phenotype even though this sex type is not natural in said plants. The invention further relates to the use of the plants and the seeds of plants of the invention. The invention further relates to the nucleic acid sequence responsible for androecy in the plants of the invention and to the polypeptide encoded by said nucleic acid sequence. Finally, the invention relates to methods of identifying the plants and seeds of the invention.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (France)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
Inventeur(s)
Farfournoux, Pierre
Bruhat, Alain
Jousse, Céline
Maurin, Anne-Catherine
Averous, Julien
Abrégé
The invention relates to an expression cassette including a gene of interest under the control of an inducible promoter, characterized in that said inducible promoter includes at least one CARE regulatory sequence (C/EBP-ATF responsive element) and a minimal promoter. The invention also relates to a vector and a host cell, as well as to a pharmaceutical composition including such a cassette, and to the use thereof for treating diseases by gene therapy.