Abrégé

The present invention relates to an apparatus and method for automatically managing a medical procedure for an outpatient and, more particularly, the apparatus comprising a communication interface, a memory, and a processor operably connected to the communication interface and the memory, wherein the processor is configured to: when it is detected that a patient has entered a preset area, confirm the arrival of the patient and add the patient to a list; when the patient is within a predetermined time from a predicted medical treatment time or when the patient's position in a medical treatment order falls within a predetermined range, obtain the location of the patient's terminal; when the obtained location of the patient's terminal is outside a predetermined radius, request standby for medical treatment; and when it is detected that the patient's turn in the medical treatment order has come and the patient has entered an examination room, request medical staff to perform an identity verification procedure.

Classes IPC  ?

• G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
• H04W 4/02 - Services utilisant des informations de localisation
• G08B 21/18 - Alarmes de situation
• H04W 4/80 - Services utilisant la communication de courte portée, p. ex. la communication en champ proche, l'identification par radiofréquence ou la communication à faible consommation d’énergie
• G06K 19/06 - Supports d'enregistrement pour utilisation avec des machines et avec au moins une partie prévue pour supporter des marques numériques caractérisés par le genre de marque numérique, p. ex. forme, nature, code
• G06Q 20/14 - Architectures de paiement spécialement adaptées aux systèmes de facturation

Abrégé

An embodiment of the present invention provides a device and a method for predicting viscosity by using artificial intelligence in a viscosity prediction system in order to increase accuracy and convenience for viscosity measurement. A system according to an embodiment of the present invention includes: a communication unit for receiving PPG data of a user from a wearable device; a memory; and a control unit for generating a PPG segment by preprocessing the PPG data, predicting at least one parameter of a viscosity model by reflecting the PPG segment to a pre-trained artificial intelligence model, determining the viscosity of the user by using the predicted parameter, and storing the determined viscosity in the memory.

Classes IPC  ?

• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
• G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• G06N 20/00 - Apprentissage automatique
• A61B 5/026 - Mesure du débit sanguin

Abrégé

The present invention relates to a multi-biomarker for diagnosing biliary tract cancer and a use thereof, and, more specifically, to: a composition for diagnosing biliary tract cancer, a kit and a method for diagnosing biliary tract cancer, which comprise an agent capable of measuring the levels of TAGLN2 and CA19-9 proteins or the expression levels of genes encoding same; a pharmaceutical composition for preventing or treating biliary tract cancer, comprising a TAGLN2 inhibitor and a CA19-9 inhibitor; and a method for preventing or treating biliary tract cancer. The biomarker TAGLN2 according to the present invention enables biliary tract cancer to be diagnosed with high specificity and sensitivity, and enables biliary tract cancer to be diagnosed with increased accuracy when combined with CA19-9. Furthermore, TAGLN2 expression in the stroma can predict the prognosis of biliary tract cancer patients.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet

Abrégé

An embodiment provides an industrial muscle-strength assistive robot, including: a wearing part; a pair of arm muscle-strength assistive parts connected to the upper body wearing member so as to be adjacent to the shoulders of the user and movable along an upper part of the upper body wearing member; a wire part connecting the pair of arm wearing members and the pair of arm muscle-strength assistive parts; a fixing part coupled to the upper body wearing member so as to be positioned at a bottom part of the pair of arm muscle-strength assistive parts; an auxiliary muscle strength conversion part coupled to the upper body wearing member so as to be positioned at a bottom part of the fixing part and selectively assisting one of waist muscle strength and arm muscle strength of the user; and a string twist driving part coupled to the waist wearing member.

Classes IPC  ?

• B25J 9/00 - Manipulateurs à commande programmée

Abrégé

sodCorynebacterium ammoniagenesCorynebacterium ammoniagenes, which enables regulation of gene expression and exhibits significantly stronger activity compared to conventionally used promoters, was developed, promoter variants having various strengths were identified from the developed promoter, and by using the identified improved promoters, two enzymes capable of converting a common sugar into a rare sugar were highly expressed in a single vector system, thereby enabling production of a rare sugar via a one-pot reaction. Accordingly, the promoters can be utilized for the production of a target protein or a rare sugar.

Classes IPC  ?

• C12N 15/77 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour CorynebacteriumVecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Brevibacterium
• C12N 15/67 - Méthodes générales pour favoriser l'expression

Abrégé

An embodiment may provide a metal-positive ion-MXene nanosheet hybrid composite. According to the embodiment, by providing a hybrid composite composed of metal particles/positive ions/MXene nanosheets, there is a feature that may provide a hydrogen evolution reaction catalyst having excellent electrochemical performance with a high current value and low overvoltage.

Classes IPC  ?

• C25B 11/091 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• C25B 11/031 - Électrodes poreuses

Abrégé

According to this specification, a method for providing information on hypotension implemented by a processor includes: receiving first clinical data and second clinical data for an individual; extracting a statistical value for the received first clinical data as a first feature; extracting an embedding vector for the received second clinical data as a second feature; and predicting whether the hypotension occurs in the individual within a first period by inputting the first feature and the second feature to a prediction model trained to predict whether the hypotension occurs using the first feature and the second feature as inputs.

Classes IPC  ?

• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients

Abrégé

In the present specification, as an information providing method for angiography which is implemented by a processor, an information providing method for angiography including a step of receiving a projection image of a computed tomography angiography (CTA) of an individual, a step of generating a first extraction image for a blood vessel by inputting the received CTA projection image to a first model which is trained to generate a first extraction image for the blood vessel with a CTA projection image as an input, and a step of generating a rendering image from the first extraction image.

Classes IPC  ?

• G06T 11/00 - Génération d'images bidimensionnelles [2D]
• G06T 7/00 - Analyse d'image
• G06V 10/40 - Extraction de caractéristiques d’images ou de vidéos

Abrégé

An embodiment provides a method and a computer program for predicting a parameter of a sample in an optical measurement system, and a recording medium storing the computer program for implementing the same, wherein the method includes: generating library spectral distribution data; supervising learning an artificial neural network with the library spectral distribution data; inputting measurement spectral distribution data acquired by measuring a sample; generating synthetic data by combining the measurement spectral distribution data and similar library spectral distribution data that are similar to the library spectral distribution data; inputting the synthetic data into the supervised learning artificial neural network to predict relative structural parameter coordinates; and combining similar variable measurement parameter coordinates for the similar library spectral distribution data and the predicted relative structural parameter coordinates to output actual variable parameter coordinates.

Classes IPC  ?

• G01N 21/21 - Propriétés affectant la polarisation

Abrégé

One aspect provides a pharmaceutical composition for preventing or treating ischemic heart disease, the composition comprising aspartic acid or a pharmaceutically acceptable salt thereof. The pharmaceutical composition significantly reduces the volume of infarcted areas within the myocardium, thereby exhibiting an excellent effect of preventing or treating ischemic heart disease. In addition, by further comprising ornithine or a pharmaceutically acceptable salt thereof, the composition induces a greater reduction in the volume of infarcted areas within the myocardium compared to administering aspartic acid or a pharmaceutically acceptable salt thereof alone, thereby exhibiting a superior effect of preventing or treating ischemic heart disease.

Classes IPC  ?

• A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A23L 33/125 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sirops d'hydrate de carboneModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sucresModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des alcools de sucreModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des hydrolysats d'amidon

Abrégé

A system and a method for measuring biomarkers by using a smart contact lens, according to one embodiment of the present invention, comprise: a smart contact lens worn on the eye of a subject so as to measure biomarkers in tears; and a terminal equipped with an application for collecting data of the biomarkers in tears from the smart contact lens, wherein the terminal includes a control unit for controlling that biomarkers in tears are measured after a stabilization time has elapsed from when the smart contact lens is worn on the eye of the subject.

Classes IPC  ?

• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
• G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux

Abrégé

A pneumatic energy generation device includes at least one pneumatic generation unit including a pneumatic supply member that supplies stored pneumatic energy to an actuator, a pneumatic generation member that generates the pneumatic energy by adjusting the pressure of the pneumatic supply member, and at least one pneumatic reinforcement unit including a liquid-gas chamber that receives a liquefied gas and a liquid-fluid chamber that receives a liquid fluid, thereby selectively mixing the liquid fluid into the liquefied gas according to the pressure of the pneumatic supply member to selectively gasify the liquefied gas and increasing the pneumatic energy while cooling the pneumatic generation member.

Classes IPC  ?

• F15B 21/0423 - Refroidissement
• B25J 9/14 - Manipulateurs à commande programmée caractérisés par des moyens pour régler la position des éléments manipulateurs à fluide
• F15B 15/20 - Autres parties constitutives

Abrégé

The present invention relates to an infectious disease transmission zone identification method, and an apparatus using same. The method is an infectious disease transmission zone identification method implemented by a processor, comprising the steps of: receiving at least one stay area for an infectious disease patient; receiving, from a spatial atmospheric pressure measurement sensor, measured atmospheric pressure of the stay area and a first area connected to the stay area so that air flows therebetween; determining that the stay area has either negative pressure or positive pressure on the basis of the atmospheric pressure of the stay area and the first area; and determining a transmission zone for the infectious disease according to whether the stay area has negative pressure or positive pressure.

Classes IPC  ?

• G16H 50/80 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la détection, le suivi ou la modélisation d’épidémies ou des pandémies, p. ex. de la grippe
• H04W 4/80 - Services utilisant la communication de courte portée, p. ex. la communication en champ proche, l'identification par radiofréquence ou la communication à faible consommation d’énergie
• G01L 19/08 - Moyens pour l'indication ou l'enregistrement, p. ex. pour l'indication à distance

Abrégé

Electrospun nanofiber membranes are provided. The membranes are electrospun from a suitable biocompatible and biodegradable biopolymer, e.g. gelatin, collagen, etc., to generate a membrane, which is then cross-linked. The membrane may be seeded with cells. The compositions find use tissue regeneration, particularly in repair, regeneration, and/or reconstruction of lamellar or partial defects of wounded corneal tissue.

Classes IPC  ?

• D01D 5/00 - Formation des filaments, fils ou similaires
• A61F 2/14 - Parties d'yeux, p. ex. cristallins ou implants de cornéeYeux artificiels
• A61L 27/14 - Matériaux macromoléculaires

Abrégé

The present invention provides a method for predicting ion distribution in a lithium-sulfur battery. In one embodiment, the method for predicting ion distribution in a lithium-sulfur battery may comprise: a first step of forming ion distribution image data in the battery by inputting a boundary value of the battery and an initial value of the battery into a data formation unit that includes a battery internal ion distribution prediction model based on numerical analysis; and a second step of inputting an initial battery state and the ion distribution image data obtained in the first step into an image generation unit so as to output an ion distribution prediction image through an LSTM-based artificial intelligence block.

Classes IPC  ?

• G16C 20/70 - Apprentissage automatique, exploration de données ou chimiométrie
• G16C 20/80 - Visualisation de données
• G16C 10/00 - Chimie théorique computationnelle, c.-à-d. TIC spécialement adaptées aux aspects théoriques de la chimie quantique, de la mécanique moléculaire, de la dynamique moléculaire ou similaires
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/42 - Procédés ou dispositions pour assurer le fonctionnement ou l'entretien des éléments secondaires ou des demi-éléments secondaires
• G06N 3/0442 - Réseaux récurrents, p. ex. réseaux de Hopfield caractérisés par la présence de mémoire ou de portes, p. ex. mémoire longue à court terme [LSTM] ou unités récurrentes à porte [GRU]
• G06N 7/01 - Modèles graphiques probabilistes, p. ex. réseaux probabilistes

Abrégé

The present invention relates to a method for treating cancer exhibiting high expression of SFRP4. In particular, the present invention was developed through intensive research to identify a highly reliable treatment method for stem cell-type gastric cancer that has the worst prognosis and for which effective therapeutic agents are difficult to develop. As a result, it was confirmed that the cancer stem cell properties decreased when Wnt protein was injected to the MKN1 gastric cancer cell line, which exhibits high expression of SFRP4. In addition, it was confirmed that secreted frizzled-related protein 4 (SFRP4), phosphorylated and secreted by protein kinase A (PKA) can form a complex with β-catenin and TCF4 to increase transcription of Wnt target genes, and by inhibiting PKA to prevent phosphorylation of SFRP4, a decrease in cancer stem cell properties was observed, which leads to the completion of the present invention. The invention can be advantageously used as a novel therapeutic agent for stem cell-type gastric cancer.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• A61K 31/472 - Isoquinoléines non condensées, p. ex. papavérine
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to a composition for maturation of adrenal organoids, a method for maturation of adrenal organoids using same, and a method for transplantation of organoids prepared by the method. In the present invention, the structurally and functionally mature adrenal organoids prepared under optimized culture conditions using the composition for maturation of adrenal organoids containing adrenocortical hormone and cyclic adenosine monophosphate have been structurally and functionally improved, and it was confirmed that the adrenal organoid chip having a three-dimensional vascular network structure manufactured using the same actually replaces the function of the adrenal gland without side effects after transplantation into a mouse. Accordingly, the present invention can be advantageously used for transplantation or regenerative therapy, drug screening, drug responsiveness evaluation, and the like.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains

Abrégé

An embodiment relates to a depsipeptide-based building block for inhibiting protein-protein interactions, a nanostructure including the same, and a use thereof, wherein the depsipeptide-based building block may remain in the body and cells for a long time when administered in vivo and be delivered to a target tissue with high efficiency, and a peptide for inhibiting protein-protein interactions may be gradually released over a long time to obtain a high effect.

Classes IPC  ?

• A61K 38/15 - DepsipeptidesLeurs dérivés
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Agents anticancéreux
• B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
• C07K 11/00 - Depsipeptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminéeLeurs dérivés

Abrégé

Disclosed are a VACNT transfer method, a VACNT transfer system for the entire substrate, and a VACNT device. The VACNT transfer method comprises: a first step of cooling a substrate to be transferred, to condense and cool water vapor on the surface of the substrate to be transferred, thereby forming an ice layer; and a second step of liquefying the ice layer and then cooling same again, while VACNTs are disposed on the ice layer.

Classes IPC  ?

• C01B 32/168 - Post-traitement

Abrégé

The present invention relates to a method for providing a clinical decision making support system, comprising the steps of: acquiring medical data including a diagnosis history of an object; determining a plurality of treatment guides for the object by inputting the medical data to each of a plurality of medical information providing models trained to determine a treatment guide by using medical data as an input; and providing a user interface including the plurality of treatment guides for the object.

Classes IPC  ?

• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
• G16H 70/20 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des pratiques ou des directives
• G16H 20/00 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients

Abrégé

An embodiment provides a device for measuring the obstruction of a tracheostomy tube, the trachea, and the bronchus, the device comprising an obstruction measurement unit (100) which is coupled to the entrance (11) of a tracheostomy tube where tracheostomy has been performed, and transmits a sound wave and receives a reflected sound wave to measure an obstruction site in any one of the tracheostomy tube (A), the trachea (B), and the bronchus (C).

Classes IPC  ?

• A61B 8/08 - Applications cliniques
• A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores

Abrégé

The present technology relates to a grid-forming power conversion control technology and, more specifically, to a grid-forming power conversion control device and a grid-forming power conversion control method. According to an embodiment, the output frequency of a grid-forming power conversion device can be controlled without a complicated current controller, which enables a simple structure and a high control speed.

Classes IPC  ?

• H02J 3/38 - Dispositions pour l’alimentation en parallèle d’un seul réseau, par plusieurs générateurs, convertisseurs ou transformateurs

Abrégé

A micro-electromechanical system (MEMS) electric field sensor using a resonant torsional shutter and a method of manufacturing the MEMS electric field sensor are described. A method of manufacturing a micro-electromechanical system (MEMS) electric field sensor according an embodiment includes: forming a metal layer on a wafer having a handle layer, a buried oxide layer arranged on the handle layer, and a device layer arranged on the buried oxide layer; patterning the metal layer to form a plurality of electrical pads thereon, forming a comb drive actuator on the device layer, the comb drive actuator including a sensing electrode and a torsional shutter configured to be resonant torsionally driven; forming a driving space of the torsional shutter in the handle layer; and etching and releasing the buried oxide layer.

Classes IPC  ?

• B81B 3/00 - Dispositifs comportant des éléments flexibles ou déformables, p. ex. comportant des membranes ou des lamelles élastiques
• B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat

Abrégé

An electronic device, according to various embodiments, comprises: a camera module; at least one processor; and a memory, wherein the memory may store instructions that, when executed by the at least one processor, instruct the electronic device to: acquire at least three feature coordinates from a palm image obtained via the camera module; identify a rotation angle of a palm on the basis of the at least three feature coordinates; and adjust a palm print recognition region on the basis of the rotation angle of the palm.

Classes IPC  ?

• G06V 40/12 - Empreintes digitales ou palmaires
• G06V 40/13 - Capteurs à cet effet
• G06V 10/24 - Alignement, centrage, détection de l’orientation ou correction de l’image

Abrégé

The present disclosure relates to a method of forming a thin film having excellent properties by depositing an organometallic compound (particularly, an organometallic compound containing rare earth metals) and to a thin film formed thereby.

Classes IPC  ?

• C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction
• C01B 33/20 - Silicates
• C23C 16/40 - Oxydes
• C23C 16/44 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement

Abrégé

Pseudomonas aeruginosaPseudomonas aeruginosaPseudomonas aeruginosaPseudomonas aeruginosa.

Classes IPC  ?

• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• A61K 35/76 - VirusParticules sous-viralesBactériophages
• A61P 31/04 - Agents antibactériens
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire

Abrégé

An embodiment relates to a method for producing a self-assembly polymer membrane by non-solvent induced film formation (NIFF), the method including: (a) preparing a polymer solution by mixing an ionized polymer with an organic solvent, (b) preparing a substrate on which a polymer solution coating layer is formed by coating the polymer solution on a substrate and (c) forming an ionized polymer membrane by immersing the substrate on which the polymer solution coating layer is formed in a non-solvent without going through a drying process under elevated temperature conditions. Accordingly, it is possible to produce a nonporous, dense polymer membrane in an efficient way that saves time and energy.

Classes IPC  ?

• B29C 41/00 - Façonnage par revêtement d'un moule, noyau ou autre support, c.-à-d. par dépôt de la matière à mouler et démoulage de l'objet forméAppareils à cet effet
• B29C 41/08 - Revêtement d'une forme, d'un noyau ou d'un autre support par pulvérisation ou fluidisation, p. ex. pulvérisation de poudre
• B29C 41/12 - Étalement de la matière à mouler sur un support
• B29C 41/14 - Immersion d'un noyau
• B29K 61/00 - Utilisation de polymères de condensation d'aldéhydes ou de cétones comme matière de moulage
• C09D 139/04 - Homopolymères ou copolymères de monomères contenant des hétérocycles possédant de l'azote dans le cycle
• C25B 13/08 - DiaphragmesÉléments d'espacement caractérisés par le matériau à base de matériaux organiques
• H01M 8/0221 - Résines organiquesPolymères organiques

Abrégé

The present invention provides a biocompatible three-dimensional scaffold and a composition for reconstructing lost tissue comprising the same. The scaffold of the present invention provides a mechanical support for a tissue cavity due to its strong physical strength and, at the same time, efficiently induces quantitative restoration of irreversibly lost tissue because the internal space thereof may be filled with active ingredients for tissue regeneration. In addition, when the spherical scaffold of the present invention is used, it may be efficiently inserted into a tissue cavity having any shape, and may also be degraded at an appropriate time after the completion of regeneration, indicating that it is useful as a scaffold for human transplantation for restoring various adipose tissues, including breast tissue.

Classes IPC  ?

• A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 27/24 - Collagène
• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• A61L 27/56 - Matériaux poreux ou cellulaires

Abrégé

An embodiment provides a multi-sensor and an early diagnosis system using the same, wherein the multi-sensor diagnoses a disease by using deep learning technology after obtaining a plurality of different electric signals obtained through reactions with target materials that respectively contact a plurality of sensors equipped in the multi-sensor.

Classes IPC  ?

• G01N 27/27 - Association de plusieurs systèmes ou cellules de mesure, chacun mesurant un paramètre différent, dans laquelle les résultats des mesures peuvent être, soit utilisès indépendamment, les systèmes ou les cellules étant physiquement associés, soit combinés pour produire une valeur représentative d'un autre paramètre
• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
• G01N 27/327 - Électrodes biochimiques
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques

Abrégé

A method of transmitting and receiving a signal at a terminal in a wireless communication system may be provided. A method of, at a terminal, transmitting and receiving a signal may comprise generating a first signal at transmitting end of the terminal and transmitting the generated first signal through an antenna and receiving a second signal through the antenna and transferring the second signal to a receiving end of the terminal. A differential circulator may be provided between the transmitting end and receiving end and the antenna, and the first signal may be transmitted and the second signal may be received at the same time based on the differential circulator.

Classes IPC  ?

• H04B 1/56 - Circuits utilisant la même fréquence pour la communication bilatérale avec possibilité de communication simultanée dans les deux directions
• H01P 1/38 - Circulateurs
• H04L 5/14 - Fonctionnement à double voie utilisant le même type de signal, c.-à-d. duplex

Abrégé

The present specification provides a method for providing information on ulcerative colitis by means of a processor, the method comprising: a step for receiving a Korean Ulcerative Colitis-Specific Questionnaire (K-UCSQ) score for an individual; and a step for determining an inflammatory bowel disease prognosis for the individual on the basis of the received K-UCSQ score.

Classes IPC  ?

• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients

Abrégé

The present specification provides a method for providing information on the metachronous recurrence of gastric cancer, the method comprising the steps of: measuring a level of mRNA of at least one marker gene from among CD8, CD4, and PD-L1 or a protein thereof in a biological sample isolated from a subject; and determining the possibility of metachronous gastric cancer recurrence in the subject on the basis of the measured level of mRNA of the marker gene or protein thereof.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

This server device may comprise: a transceiver for transmitting/receiving data to/from at least one robot device; and a controller for controlling the transceiver and selecting an image analysis policy for control of the robot device, wherein the controller collects at least one of state information of a wireless network connected to the robot device, meta information of the robot device, and task characteristic information of the robot device, and determines the image analysis policy on the basis of the collected information.

Classes IPC  ?

• H04L 67/125 - Protocoles spécialement adaptés aux environnements propriétaires ou de mise en réseau pour un usage spécial, p. ex. les réseaux médicaux, les réseaux de capteurs, les réseaux dans les véhicules ou les réseaux de mesure à distance en impliquant la commande des applications des terminaux par un réseau
• G06T 7/00 - Analyse d'image
• H04L 43/0888 - Débit
• H04L 43/0894 - Taux de paquets
• H04L 65/65 - Protocoles de diffusion en flux de paquets multimédias, p. ex. protocole de transport en temps réel [RTP] ou protocole de commande en temps réel [RTCP]

Abrégé

The present invention provides a method for mass-producing a thermoelectric element with a novel structure, comprising steps in which: (a) a spacer part positioned inside a mold part is filled with thermoelectric powder so that the inner and outer sides of the spacer part are encompassed; (b) a punch part presses the spacer part; (c) spark plasma is used to sinter the thermoelectric powder, thereby generating a sintered body; and (d) the sintered body is cut into predetermined sizes so as to manufacture a plurality of thermoelectric elements.

Classes IPC  ?

• H10N 10/01 - Fabrication ou traitement
• H10N 10/85 - Matériaux actifs thermoélectriques
• H10N 10/10 - Dispositifs thermoélectriques comportant une jonction de matériaux différents, c.-à-d. dispositifs présentant l'effet Seebeck ou l'effet Peltier fonctionnant exclusivement par les effets Peltier ou Seebeck

Abrégé

An embodiment provides a mass-manufacturing method of new structure thermoelectric elements, including: (a) filling a thermoelectric material powder so as to surround the inner and outer parts of a spacer portion located inside a mold portion; (b) pressurizing the spacer portion by a punch portion; (c) sintering the thermoelectric material powder using spark plasma to produce a sintered body; and (d) cutting the sintered body to a preset size to manufacture a plurality of thermoelectric elements.

Classes IPC  ?

• H10N 10/01 - Fabrication ou traitement
• H10N 10/817 - Détails structurels de la jonction la jonction étant inamovible, p. ex. obtenue par cémentation, frittage ou soudage

Abrégé

Provided in the present specification are a method for preparing an orthodontic adhesive composition, and an orthodontic adhesive composition prepared thereby, the method comprising the steps of: using white Portland cement and distilled water so as to prepare white hydrated Portland cement (hPC); mixing the prepared hPC and a silanized glass filler so as to prepare a filler mixture; and mixing the filler mixture and a resin substrate containing a resin monomer, so as to prepare the orthodontic adhesive composition.

Classes IPC  ?

• A61K 6/30 - Compositions pour fixer temporairement ou de façon permanente les dents ou les palais, p. ex. apprêts pour adhésifs dentaires
• A61K 6/70 - Préparations pour la technique dentaire comprenant des additifs inorganiques
• A61C 7/16 - BracketsFixation des brackets aux dents spécialement conçus pour être scellés aux dents

Abrégé

The present disclosure relates to a device and method for precisely measuring skin moisture, and more particularly, to a device and method for precisely measuring skin moisture in which measurement of skin moisture is not affected by pressure applied to the device. A device for precisely measuring skin moisture according to one aspect of the present disclosure may include a main body which is open toward a measurement target and has a hollow portion, a contact part slidably mounted on the main body and having a window provided thereon to come in contact with the measurement target, and a connector which includes an elastic member provided to connect the main body and the contact part and be compressed during sliding of the contact part into the main body.

Classes IPC  ?

• A61B 5/0507 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio utilisant des micro-ondes ou des ondes térahertz
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

An embodiment relates to a phenol-modified decellularized muscle tissue-derived extracellular matrix (MEM) for muscle regeneration and a method for preparing same. The phenol group-modified decellularized MEM of the embodiment is characterized by containing components similar to original proteins of muscle tissue for muscle regeneration and forming a hydrogel having a stable porous nanofiber structure through dimerization crosslinking between phenol groups, wherein the hydrogel can effectively treat muscle injury or muscle diseases by being administered or implanted into muscle tissue without causing side effects such as an immune response or liver or kidney dysfunction.

Classes IPC  ?

• A61L 27/38 - Cellules animales
• A61K 35/34 - MusclesCellules musculaires lissesCœurCellules souches cardiaquesMyoblastesMyocytesCardiomyocytes
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
• C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires

Abrégé

The present invention relates to exosomes comprising an miRNA pool based on the inhibition of TGF-β signaling involved in cancer growth and metastasis. The exosomes, which are derived from tripartite motif containing 40 (TRIM40) transformed cells treated with staurosporine, comprise a pool of miRNAs that inhibit the expression of ECM- and EMT-related genes, the miRNAs include miR-1343-3p (which inhibits the expression of TGBR1 and TGFBR2), miR-4285 (which inhibits the expression of the TGFB1 gene), and miR-194-3p (which inhibits the TGF-beta signaling pathway), which inhibit the TGF-beta signaling pathway in cancer cells, thereby comprehensively blocking the expression of EMT- and ECM-related genes by surpassing a one-dimensional method of loading one specific miRNA or a small molecule that exhibits anticancer activity so as to inhibit TGF-beta signaling pathways when the miRNAs are absorbed and delivered into cancer cells, and thus the cancer microenvironment is modulated such that strong anticancer responses can be induced in preclinical settings.

Classes IPC  ?

• A61K 35/13 - Cellules tumorales, quel que soit le tissu d’origine
• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61P 35/00 - Agents anticancéreux
• A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
• A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
• A23L 33/13 - Acides nucléiques ou leurs dérivés

Abrégé

The present specification provides a method for providing information about colorectal cancer, and a kit and a drug screening method that are based thereon, the information provision method comprising the steps of: measuring the level of mRNA of an IgA maturation (IGAM) marker gene for a biological sample isolated from an individual, or the level of protein encoded by the mRNA; and determining the prognosis of colorectal cancer of the individual on the basis of the measured level of mRNA for the marker gene or the measured level of protein encoded by the mRNA.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

An embodiment of the present invention provides a technology for configuring a switch-capacitor direct current boosting device together with a thermoelectric element, thereby allowing the connection of a capacitor to vary in each of: a case in which the capacitor stores electricity due to the production of electricity by the thermoelectric element, and a case in which an electric device operates due to the discharge of electricity from the capacitor. A wearable device capable of switch-capacitor direct current boosting for efficient use of a wearable thermoelectric power generating element according to an embodiment of the present invention comprises: a thermoelectric element for generating electricity by contacting a user's body surface; an energy storage module connected to the thermoelectric element and having multiple capacitors for storing the electricity generated by the thermoelectric element; a switch module having multiple switch units and allowing one capacitor among the multiple capacitors and another capacitor to be connected in series or in parallel with each other; and a device unit for receiving electricity from the multiple capacitors when each of the multiple capacitors is connected in series by operation of the switch units.

Classes IPC  ?

• H02J 7/00 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries
• H10N 10/80 - Détails de structure
• G06F 1/16 - Détails ou dispositions de structure

Abrégé

The present invention relates to a decellularized cancer tissue-derived extracellular matrix scaffold and a use thereof. The decellularized cancer tissue-derived extracellular matrix according to the present invention contains a large amount of a malignant tumor-related extracellular matrix and proliferation and metastasis components that are more distinct than existing mouse-derived scaffolds or decellularized normal tissue-derived scaffolds, thereby achieving a better cancer tissue-specific microenvironment. A cancer organoid cultured using the decellularized cancer tissue-derived extracellular matrix was found to have improved cancer-specific markers, proliferative capacity, size, and secretion of inflammatory cytokines, and better achieve a configuration and phenotype of cancer tissues at a level similar to the actual configuration and phenotype, and thus can be effectively used in disease modeling, drug screening, new drug toxicity evaluation, personalized drug selection, and the like.

Classes IPC  ?

• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• C12N 5/09 - Cellules tumorales
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

One embodiment of the present invention provides a technique for using a wearable device worn on a finger of a user to measure the blood pressure of the user and use same to determine whether the user is a glaucoma suspect. A wearable device for monitoring glaucoma suspect, according to one embodiment of the present invention, comprises: a housing having a ring shape and having an inner space; a sensor unit coupled to the housing and contacting the skin of a user to measure pulse waves of the user; a communication unit for receiving and processing a signal of the sensor unit to generate a transmission signal which is a transmitted signal; and an analysis unit for receiving and analyzing the transmission signal.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin

Abrégé

The present invention comprises a method for providing information about demodex mites and a device based on the method, the method comprising the steps of: extracting a first feature of the demodex mites by inputting a face image of an individual to a trained first prediction model; generating a saliency map from the first feature; acquiring regions of interest in the face as one or more patches; extracting a second feature of the demodex mites by inputting the one or more patches to a second prediction model; and predicting a final density probability of the demodex mites for the individual by inputting the first feature and the second feature to a third prediction model trained to predict the density probability of the demodex mites for the individual.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
• G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS

Abrégé

The present disclosure relates to a thermal runaway of lithium-ion battery detection and control device including: sensor modules for detecting and monitoring hydrogen concentrations of battery cells and each having a palladium-based nano sensor and a communication unit; and a battery cell controller for turning on and off charging/discharging switches of the battery cells according to the hydrogen concentrations detected through the sensor modules and variations in the hydrogen concentrations according to time, wherein the palladium-based nano sensor detects the hydrogen concentration between 20 and 400 ppm.

Classes IPC  ?

• G01N 27/12 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de l'absorption d'un fluideRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de la réaction avec un fluide
• B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
• H01M 10/42 - Procédés ou dispositions pour assurer le fonctionnement ou l'entretien des éléments secondaires ou des demi-éléments secondaires
• H01M 10/44 - Méthodes pour charger ou décharger

Abrégé

One of the most important technical problems to be solved in the present specification is that of providing a prime editor capable of exhibiting an actual therapeutic effect by selecting a prime editor exhibiting an effect of correcting c.4957dupA mutation of an EYS gene of actual human retinal cells from among numerous theoretically designable prime editors and specifying a configuration thereof. In order to solve this technical problem, the present specification provides a prime editor and a component thereof, wherein the prime editor is screened through a high-throughput screening method, is verified in actual human retinal cells, and can actually correct the c.4957dupA mutation of the EYS gene. The prime editor disclosed in the present specification acts on human retinal cells including the c.4957dupA mutation in the EYS gene, thereby being able to correct the EYS gene to a normal state. Therefore, the prime editor can be used as a therapeutic agent for retinitis pigmentosa caused by the c.4957dupA mutation in the EYS gene.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 9/22 - Ribonucléases
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61P 27/02 - Agents ophtalmiques

Abrégé

The present disclosure relates to a method for isolating, maintaining, proliferating and differentiating monoclonal cells derived from human salivary gland epithelial stem cells or progenitor cells, and a production method for extracellular vesicles for treating salivary gland diseases. More specifically, conditions for isolating monoclonal salivary gland epithelial cells through an optimized subfractionation culturing method from a small amount of major salivary gland or minor salivary gland tissue obtained during surgery or biopsy processes have been established, and culture medium conditions for enabling long-term culture of salivary gland epithelial stem cells or progenitor cells in 2D have been established. Such high-purity monoclonal cells derived from human salivary gland epithelial stem cells or precursor cells are expected to be utilized not only as cell therapy products for fundamental treatment of salivary gland dysfunction and as candidates for extracellular vesicles, but also widely throughout salivary gland studies such as disease modeling, pathology research, drug screening, toxicity evaluation, and genetic manipulation.

Classes IPC  ?

• A61K 35/38 - EstomacIntestinCellules caliciformesMuqueuse oraleSalive
• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains

Abrégé

The present invention relates to the discovery of an agent for measuring the expression level of a protein that induces the acquisition of metastatic ability by tumor cells, or a gene encoding the same, and a method for preventing or treating metastatic cancer by controlling the expression of the protein or gene. The present invention provides effective biomarkers for metastatic cancer that are capable of significantly improving the patient's survival rate when detected early, and provides a method capable of predicting with high reliability the likelihood that primary cancer will progress to metastatic cancer. Thus, the present invention may be useful for efficient prevention or treatment of metastatic cancer by inhibiting the expression of these factors.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

Embodiments include a biogas production device including a conductive support-based dynamic biofilm with improved biogas productivity by using, as a support, a conductive support having a surface on which a dynamic biofilm of an electroactive microbial community is formed, and a biogas production method using the device. The biogas production device comprises: a reaction tank for producing an organic wastewater mixture by mixing organic wastewater and anaerobic microbial community formation to produce biogas; a dynamic biofilm module for filtering the organic wastewater mixture transferred from the reaction tank using a porous conductive support having a dynamic biofilm formed on a surface thereof; and a storage tank for measuring and storing an amount of biogas produced in the reaction tank.

Classes IPC  ?

• C02F 3/28 - Procédés de digestion anaérobies
• C02F 3/00 - Traitement biologique de l'eau, des eaux résiduaires ou des eaux d'égout
• C12P 3/00 - Préparation d'éléments ou de composés inorganiques à l'exception du dioxyde de carbone

Abrégé

The present invention provides a composition for differential diagnosis of urothelial papilloma, and an information provision method using same. By using the composition and the information provision method of the present invention, urothelial papilloma can be distinguished from low-grade urothelial carcinoma, which had been difficult to distinguish by tumor morphological shape in a conventional histopathological examination.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The present invention relates to a WKYMVm peptide analog comprising an amino acid sequence of Trp (W)-Lys (K)-Tyr (Y)-Met (M)-Val (V)-D-Met (m), in which at least one amino acid residue selected from the group consisting of Lys (K), Tyr (Y), and Met (M) in the amino acid sequence is substituted with a β3-amino acid residue or a peptoid residue, and a use thereof. The WKYMVm peptide analogs of the present invention has effects of increasing stability by increasing in vivo degradation half-life and of promoting activation of innate immune responses by neutrophils through activation of formyl peptide receptors, and thus can be effectively used in preventing or treating a disease that is be prevented or treated by formyl peptide receptors, especially an infectious disease or inflammatory disease.

Classes IPC  ?

• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• C07K 7/02 - Peptides linéaires contenant au moins une liaison peptidique anormale

Abrégé

The present invention provides an endoscopic pipette and an observation system, the endoscopic pipette is configured to remove a culture medium accommodated in a culture vessel, in which spheroids are cultured, and observe the spheroids in the culture vessel, and the endoscopic pipette includes a tip unit configured to be inserted into the culture vessel to extract the culture medium, an accommodation unit configured to accommodate the culture medium extracted by the tip unit, a camera unit provided between the tip unit and the accommodation unit, disposed adjacent to the tip unit, and configured to capture an image of an interior of the culture vessel, and a power unit provided in a partial space of the accommodation unit and configured to provide power to the camera unit.

Classes IPC  ?

• B01L 3/02 - BurettesPipettes

Abrégé

The present disclosure relates to a cell obtaining method for creating NFT based on a cell image. The cell obtaining method includes the steps of separating a cell from a biological sample, obtaining a stem cell by treating the cell with a dedifferentiation inducer, differentiating the stem cell, acquiring an image of the differentiated cell; and converting the image of the differentiated cell into an NFT image, and creates the NFT using a vital image in a simple and easy way through non-invasive and non-medical procedures.

Classes IPC  ?

• C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
• C12N 5/0793 - Neurones

Abrégé

KLRB1KLRB1 mRNA or a protein encoded by the mRNA or CD161+ tissue-resident memory T cells as a marker for predicting a response to immunotherapy in HPV-induced cancer.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• C12Q 1/6881 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour le typage de tissu ou de cellule, p. ex. sondes d’antigène leucocytaire humain [HLA]
• A61P 35/00 - Agents anticancéreux
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

Disclosed are a DNA clock capable of recording long periods of time, comprising a composition for measuring or estimating elapsed time in cells, and a method of measuring or estimating elapsed time in cells using the composition.

Classes IPC  ?

• C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
• C12Q 1/6811 - Méthodes de sélection pour la production ou l’élaboration d’oligonucléotides spécifiques cibles ou de molécules de liaison
• C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p. ex. séquençage par hybridation [SBH]

Abrégé

This application relates to a tumor tissue model in which tumor tissue isolated from a patient can be cultured. The tumor tissue model uses tumor tissue isolated from a patient, and thus the tumor tissue can be cultured while maintaining the extracellular matrix of tumor cells. Since the tumor tissue is cultured in an environment similar to the actual environment inside the body, the tumor tissue model can be used for patient-tailored drug screening, drug response evaluation, radiation reactivity evaluation, tumor-related research, clinical evaluation, animal replacement tests, disease modeling, etc.

Classes IPC  ?

• C12N 5/09 - Cellules tumorales

Abrégé

The present invention relates to a method by which a processor of a Demodex folliculorum prediction device provides information about Demodex folliculorum, and provides a method for providing information about Demodex folliculorum, and a device based thereon, the method comprising the steps of: receiving a face image of an individual; acquiring, as one or more patches, regions of interest in the face from the received face image; inputting the face image and each of the patches into a plurality of first density prediction models trained to input the face image and each of the patches so as to predict the density probability of Demodex folliculorum, thereby making a first prediction about the density probability of Demodex folliculorum for the face image and each of the patches; and inputting the density probability of Demodex folliculorum for the face image and each of the patches into a single second density prediction model trained to input the density probability of a plurality of Demodex folliculorums so as to predict the density probability of Demodex folliculorum for an individual, thereby making a second prediction about the density probability of the final Demodex folliculorum.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
• G06N 20/20 - Techniques d’ensemble en apprentissage automatique

Abrégé

The present disclosure relates to a management system for generating and distributing a cell image-based NFT including a cell image generation unit that generates an image from a collected cell, an NFT issuance unit that converts the cell image into an NFT image and stores and manages the NFT image, and an NFT transaction unit that brokers an online transaction for the issued NFT, and a service providing method thereof, and may assign an asset value to a vital image to meet the demand for owning the image.

Classes IPC  ?

• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G06F 21/10 - Protection de programmes ou contenus distribués, p. ex. vente ou concession de licence de matériel soumis à droit de reproduction
• H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système

Abrégé

The present invention relates to a composition for fixative exchange, comprising an organic catalyst and a platinum-based cross-linking agent. The composition of the present invention allows site-selective binding without interfering with Watson-Crick base pairs of nucleic acids and allows nucleic acids having reacted with a fixative to be restored to the state before reacting with the fixative, thereby enabling reverse transcription efficiency to be maximized, and thus can be effectively used in the field of diagnosing diseases or discovering a target material for new drug development through transcriptome analysis or multi-omics analysis from a single cell or a single nucleus.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
• C12Q 1/6869 - Méthodes de séquençage
• G01N 1/36 - Enrobage ou montage analogue d'échantillons

Abrégé

A composition comprising a decellularized uterine tissue-derived extracellular matrix and a use thereof and, more specifically, a hydrogel composition for three-dimensional culturing an endometrial organoid, a preparation method therefor, and a use thereof are described. The hydrogel composition comprising a decellularized uterine tissue-derived extracellular matrix can be utilized to fabricate an endometrial organoid highly similar to in vivo uterine tissues and organs through the properties, components, and physical properties of the decellularized uterine tissue-derived extracellular matrix, and such endometrial organoids can be advantageously used for in-vivo implantation and in drug tests for various uterus-related diseases.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet

Abrégé

122) multiple emulsion.

Classes IPC  ?

• C11B 9/00 - Huiles essentiellesParfums
• B01J 13/02 - Fabrication de microcapsules ou de microbilles
• C08L 67/04 - Polyesters dérivés des acides hydroxycarboxyliques, p. ex. lactones

Abrégé

Provided herein are a method for providing information on recovery from acute kidney injury and a kit therefor, the method including the steps of: measuring a level of at least one amino acid of glutamine, glutamic acid, arginine, and tryptophan at a predetermined time with respect to a biological sample isolated from an individual; and determining whether there is a possibility of recovery from acute kidney injury (AKI) for the individual within a predetermined period of time on the basis of the measured level of amino acids.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/70 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir la créatine ou la créatinine

Abrégé

A voltage measurement type glucose sensor comprises a microneedle array including a flat part and a plurality of microneedles located on one surface of the flat part; an enzyme layer located on a surface of the plurality of microneedles and including glucose oxidase; a supercapacitor located on the other side of the flat part; and a wireless communication module electrically connected to the supercapacitor, and a glucose measurement method using the same. The glucose sensor is self-driving without the need to apply separate external power, improving the lifespan of the device and enabling close monitoring of accurate glucose levels in real time,

Classes IPC  ?

• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques en utilisant des électrodes enzymatiques, p. ex. avec oxydase immobilisée

Abrégé

Please enter in the present application the English translation of the abstract of the Korean language application that was filed in the USPTO on Jun. 12, 2024, as contained in the English translation of the application in Appendix B of the Translator Certificate filed herewith, and as separately filed herewith in .docx format (728_Patent_Application_ABSTRACT.docx).

Classes IPC  ?

• C12N 9/78 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5)
• C12N 9/22 - Ribonucléases
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• C12Q 1/44 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase une estérase

Abrégé

The present invention relates to a method for screening for an inhibitor against the blood-brain barrier passage of Cryptococcus neoformans, a method for screening for an antifungal agent, and an antifungal composition. The screening method of the present invention uses a novel gene that regulates the blood-brain barrier passage of Cryptococcus neoformans, and thus can effectively screen for an inhibitor against blood-brain barrier passage and an antifungal agent.

Classes IPC  ?

• C12Q 1/6851 - Amplification quantitative

Abrégé

Provided are: a peptide targeting Fusobacteria, comprising a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 77 to 83; a composition for diagnosing cancer, comprising same; and a drug delivery composition. The peptide targeting Fusobacteria accurately targets Fusobacteria, which are harmful bacteria in various diseases, including cancer, and thus can be effectively used in cancer diagnosis and drug delivery.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

Provided in one embodiment of the present invention is a polymer micelle having a micelle structure composed of an amphiphilic material with both a hydrophilic group and a hydrophobic group, wherein the hydrophilic group includes a polyglycerol functional group, and the hydrophobic group includes a phenol group having a hydrophobic substituent bonded to the end thereof and modified to be hydrophobic.

Classes IPC  ?

• C07C 41/03 - Préparation d'éthers à partir d'oxiranes par réaction d'un cycle oxirane avec un groupe hydroxyle
• C07C 43/23 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons contenant des groupes hydroxyle ou O-métal

Abrégé

The present invention relates to a system for reducing noise of a CBCT image and a method therefor, wherein the system can reduce noise of a CBCT image by applying the difference between the CBCT image and a CT image to artificial intelligence learning by using CYCLE GAN so as to convert CBCT image data such that it has the same standards as CT image data and provide same, the CBCT image data having low quality and more noise than the CT image data.

Classes IPC  ?

• A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
• A61B 6/03 - Tomographie informatisée
• A61B 6/58 - Leur essai, réglage ou étalonnage
• G06T 7/10 - DécoupageDétection de bords

Abrégé

In an embodiment, gas emitted during DRI processing and melting is collected and blown in refining, and gas emitted from the refining is collected and used in DRI processing, so that it is possible to circulate gas input to and emitted from each process in a DRI-Smelter-BOF (Basic Oxygen Furnace) scheme and achieve process optimization.

Classes IPC  ?

• C21C 7/068 - Décarburation
• C21B 13/00 - Fabrication de fer spongieux ou d'acier liquide par des procédés directs
• C21B 13/12 - Fabrication de fer spongieux ou d'acier liquide par des procédés directs dans des fours électriques

Abrégé

An embodiment provides a method and a system device for refining molten iron, wherein hydrogen reduction DRI is utilized to collect CO2 gas generated during melting and further reduction and use the gas in decarbonization refining, so as to optimize processes and achieve carbon neutrality. In addition, it is possible to predict the end point of the decarbonization refining by measuring the amount of CO gas generated in decarbonization refining.

Classes IPC  ?

• C21B 13/00 - Fabrication de fer spongieux ou d'acier liquide par des procédés directs
• C21B 13/12 - Fabrication de fer spongieux ou d'acier liquide par des procédés directs dans des fours électriques

Abrégé

Provided is a Mott-piezo memristor of an ABO3/CO composition, which has maximized piezo characteristics by using a method, such as doping, with various elements, an ABO3 material having a perovskite structure exhibiting Mott-transition characteristics, and inserting a CO interlayer. The Mott-piezo memristor may comprise: a bottom electrode; a top electrode arranged to face the bottom electrode; and a plurality of Mott layers and a plurality of piezoelectric layers, which are arranged between the bottom electrode and the top electrode, wherein the plurality of piezoelectric layers are arranged between the plurality of Mott layers

Classes IPC  ?

• H10N 70/00 - Dispositifs à l’état solide n’ayant pas de barrières de potentiel, spécialement adaptés au redressement, à l'amplification, à la production d'oscillations ou à la commutation
• G06N 3/065 - Moyens analogiques
• H10N 70/20 - Dispositifs de commutation multistables, p. ex. memristors

Abrégé

Present disclosure provides an apparatus for manufacturing an artificial tissue, comprising: a hydrogel accommodating structure which accommodates hydrogel including cells and has a bottom plate, a container and a cover; and a standing wave adding means for adding a standing wave to the hydrogel accommodated in the hydrogel accommodating structure, wherein cells in the hydrogel are aligned by the adding of a standing wave, and the position of the cells in the hydrogel is controlled by adjusting at least one of the attenuation coefficient of the container and the reflection coefficient of the cover.

Classes IPC  ?

• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus

Abrégé

The present invention relates to a composition for preventing or treating inflammatory or autoimmune skin disease. The composition of the present invention may be useful as a fundamental therapeutic composition that is able to efficiently ameliorate skin tissue damage caused by inflammation while having a minimized impact on systemic immune activity by specifically inhibiting the activity of skin-specific T cells. The present invention also provides a screening method capable of quickly and highly reliably identifying promising therapeutic candidates that are able to alleviate various autoimmune and inflammatory damages occurring in skin tissue by inhibiting the activity of skin-specific T cells.

Classes IPC  ?

• A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61Q 17/00 - Préparations protectricesPréparations employées en contact direct avec la peau pour protéger des influences extérieures, p. ex. des rayons du soleil, des rayons X ou d'autres rayons nuisibles, des matériaux corrosifs, des bactéries ou des piqûres d'insectes
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Provided is a self-powered pressure sensor which may show excellent pressure sensitivity by significantly improving transfer efficiency of charges generated by triboelectrification, the sensor including: a first electrode; a first triboelectrification unit positioned on the first electrode; a second triboelectrification unit including a pattern on which a microstructure is repeatedly positioned, the microstructure being reversibly in contact with or separated from the first triboelectrification unit by a physical external force, and having at least one surface in contact with the first triboelectrification unit to induce a change in a contact area; and a second electrode positioned inside the second triboelectrification unit and conformally positioned on a surface of the microstructure, wherein the first electrode and the second electrode are geometrically asymmetric to each other.

Classes IPC  ?

• H02N 1/04 - Générateurs à friction
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 5/0245 - Mesure du pouls ou des pulsations cardiaques utilisant des capteurs engendrant des signaux électriques
• G01H 17/00 - Mesure des vibrations mécaniques ou des ondes ultrasonores, sonores ou infrasonores non prévue dans les autres groupes de la présente sous-classe

Abrégé

The present invention pertains to: an engineered cell comprising a chloroplast-containing cell and a conductor inserted into the cell, wherein the conductor is inserted so as to contact or penetrate the thylakoid membrane of the chloroplast, whereby the engineered cell is engineered so that photosynthetic electrons can be extracted out of the cell by light; a metal catalyst using the engineered cell; and a hydrogen production method using the engineered cell. By using the metal catalyst according to the present invention, oxygen generated during photosynthesis can be catalyzed and self-regulated at a low concentration and protons can be catalyzed to provide a hydrogen production system and method that enable sustained hydrogen production. In addition, the present invention has the effect of providing an artificial photosynthesis system which can convert sunlight into fuel by consuming only CO2 and water as electron sources and is especially superior in terms of cost efficiency and the immediate availability of the produced fuel.

Classes IPC  ?

• C12P 3/00 - Préparation d'éléments ou de composés inorganiques à l'exception du dioxyde de carbone
• C12N 1/12 - Algues unicellulairesLeurs milieux de culture
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

Abrégé

The present invention relates to an autoimmune disease animal model and a method for preparing the same. The animal model of the present invention efficiently generates an autoantibody that causes autoimmune disease, by introducing an autoantigen-encoding gene through the Cre-LoxP system, which enables stable and continuous expression of the autoantigen at a desired time by treatment of Cre recombinase. Contrary to the conventional method that fails to effectively produce autoantibody due to leaky expression and immune tolerance, or requires repeated administration over several weeks, the present invention achieves sustainable expression of an effective amount of autoantigen by only one TAT-Cre recombinase treatment, thus may be utilized as an outstanding animal model reproducing various symptoms and molecular mechanisms of autoimmune diseases.

Classes IPC  ?

• A01K 67/027 - Nouvelles races ou races modifiées de vertébrés
• C07K 14/72 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des hormones
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales

Abrégé

An embodiment of the present invention provides a method for mechanochemical decomposition of polyvinyl chloride (PVC) using ball milling, the method comprising the steps of: ball milling PVC and a dechlorinating agent to obtain dechlorinated PVC; ball milling the dechlorinated PVC and an epoxidizing agent to obtain epoxidized PVC; and hydrolyzing the epoxidized PVC.

Classes IPC  ?

• C08J 11/26 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance organique par traitement avec des composés organiques contenant de l'oxygène contenant des groupes acide carboxylique, leurs anhydrides ou esters
• C08F 216/06 - Alcool polyvinylique
• C08F 236/04 - Copolymères de composés contenant plusieurs radicaux aliphatiques non saturés et l'un au moins contenant plusieurs liaisons doubles carbone-carbone le radical ne contenant que deux doubles liaisons carbone-carbone conjuguées

Abrégé

A pyrimidine derivative, a method for preparing the pyrimidine derivative, and a pharmaceutical composition comprising the pyrimidine derivative are disclosed. Also disclosed is a method for preventing or treating cancer which includes administering the pyrimidine derivative or a composition containing the pyrimidine derivative to a subject in need of cancer treatment or prevention. The pyrimidine derivative exhibits a high inhibitory ability against EGFR mutation and HER2 mutation, and thus can be effectively used in treatment of cancer in which EGFR mutation and HER2 mutation have occurred

Classes IPC  ?

• C07D 239/48 - Deux atomes d'azote
• A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
• C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons

Abrégé

The present invention relates to a conversion device for converting a treatment beam for treating a lesion of a subject, comprising: a collimator unit to which the treatment beam is incident and which has a plurality of slits; and a scattering unit that scatters the treatment beam that has passed through the collimator unit.

Classes IPC  ?

• A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules

Abrégé

A system for determining a sputum type using a respiratory sound according to an embodiment may comprise a data collection unit that collects respiratory sound data from a patient who has undergone tracheostomy; an image conversion unit that receives the respiratory sound data collected by the data collection unit and converts the received respiratory sound data into a spectrogram image; and a sputum type determination unit that determines a sputum type of the patient who has undergone tracheostomy using a deep learning model based on a pattern difference between the spectrogram images converted by the image conversion unit.

Classes IPC  ?

• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

The present invention provides an antibacterial composition including two or more strains selected from the group consisting of Anaerostipes hadrus, Collinsella aerofaciens, Blautia wexlerae and Bifidobacterium longum strains that inhibit the activity of antibiotic-resistant bacteria.

Classes IPC  ?

• A61K 35/745 - Bifidobactéries
• A61P 31/04 - Agents antibactériens

Abrégé

The present invention relates to a nucleic acid construct that can express and inhibit a gene simultaneously. The nucleic acid construct that can express and inhibit a gene simultaneously, according to the present invention, comprises both mRNA and siRNA in a single construct, and thus, mRNA and siRNA are introduced simultaneously into the same cell. Accordingly, a protein to be expressed may be expressed normally while expression of a particular gene may be specifically inhibited. The mRNA-siRNA nucleic acid construct activates an immune system by expressing a target protein in an antigen-presenting cell, and at the same time, overcomes interference of immune escape by blocking the activity of an immune checkpoint protein, and thus is expected to be remarkably useful in the fields of immunotherapy, especially in the field of cancer immunotherapy.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to nanoparticles comprising a decellularized spleen extracellular matrix and use thereof and, in particular, to: nanoparticles having a uniform size, which are obtained by producing hydrogel from a decellularized spleen extracellular matrix, and then freeze-milling the hydrogel; a method for producing same; use thereof; and the like. The nanoparticles comprising a decellularized spleen extracellular matrix, according to the present invention, have many excellent advantages such as an immunity-enhancing effect, biocompatibility, safety, biodegradability, and usability, and thus can be used as a novel adjuvant for enhancing vaccine immunity.

Classes IPC  ?

• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present invention provides a pharmaceutical composition, an antibacterial composition, a probiotic composition, and a food additive composition, which are for treating or preventing inflammatory diseases, and contain, as an active ingredient, any one from among a Lactobacillus animalis strain and a Limosilactobacillus reuteri strain, which have an ability to adjust uric acid concentration, mixed strains (accession number: KCTC 15190BP) of the Lactobacillus animalis and Limosilactobacillus reuteri strains, a culture medium of the Lactobacillus animalis strain, a culture medium of the Limosilactobacillus reuteri strain, and a culture medium of the mixed strains (accession number: KCTC 15190BP).

Classes IPC  ?

• C12N 1/20 - BactériesLeurs milieux de culture
• A61K 35/747 - Lactobacilles, p. ex. L. acidophilus ou L. brevis
• A61P 31/04 - Agents antibactériens
• A01N 63/20 - BactériesSubstances produites par des bactéries ou obtenues à partir de celles-ci
• A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
• A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
• C12R 1/225 - Lactobacillus

Abrégé

A multiple and broadband stealth structure comprises a radar absorption unit that absorbs broadband microwave, a low-frequency transmission filter unit that is stacked on an upper portion of the radar absorption unit, and an infrared radiation unit that is combined with the low-frequency transmission filter unit to selectively emit infrared ray, thereby selectively controlling the infrared emissivity of the surface to emit infrared radiation only through an atmospheric absorption window with a low infrared transmittance and to avoid the infrared detection system.

Classes IPC  ?

• F41H 3/00 - Camouflage, c.-à-d. moyens ou procédés de dissimulation ou de simulation
• B64D 7/00 - Agencement à bord aéronefs des équipements militaires, p. ex. des armes, des accessoires d'armement ou des blindages de protectionAdaptations des installations d'armement aux aéronefs

Abrégé

A hydrogel including phenol derivative-modified cellulose, a use thereof, and a preparation method therefor are described. Physical properties of the hydrogel can be modulated by adjusting concentrations of and oxidation conditions for the phenol derivative-modified cellulose. In addition, the hydrogel of the present invention can find applications in various fields due to its properties, such as hemostasis, blood coagulation acceleration, tissue adhesion, cell culture, cell transplantation, drug delivery, etc.

Classes IPC  ?

• A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
• A61K 9/06 - OnguentsExcipients pour ceux-ci
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/38 - CelluloseSes dérivés
• A61L 24/08 - Polysaccharides
• A61L 27/20 - Polysaccharides
• A61L 27/38 - Cellules animales
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• C08B 15/06 - Dérivés contenant des éléments autres que carbone, hydrogène, oxygène, halogènes ou soufre contenant de l'azote
• C08B 15/10 - Réticulation de la cellulose
• C08J 3/075 - Gels macromoléculaires
• C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
• C08L 1/08 - Dérivés de la cellulose

Abrégé

A heat flux sensor according to an embodiment of the present disclosure includes: a thermogalvanic cell; a first electrode and a second electrode which are respectively disposed on a first surface and a second surface of the thermogalvanic cell; and a processor configured to estimate heat flux by measuring a voltage, generated by a temperature difference between the first surface and the second surface, by using the first electrode and the second electrode, wherein core body temperature may be estimated based on the heat flux, estimated by the heat flux sensor, and a skin surface temperature of an object.

Classes IPC  ?

• G01K 13/20 - Thermomètres médicaux par contact pour les humains ou les animaux
• G01K 7/02 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments thermo-électriques, p. ex. des thermocouples
• G01K 17/00 - Mesure d'une quantité de chaleur

Abrégé

Disclosed are a transparent electrode for a solar cell and a method of manufacturing the same. The transparent electrode for a solar cell has a low Young's modulus, excellent elasticity, self-healing properties, an average visible-light transmittance sufficient to implement bifacial properties, and excellent power conversion efficiency (PCE). In addition, the method of manufacturing the transparent electrode for a solar cell does not require an additional deposition process, so the electrode-manufacturing time can be reduced, and the electrode-manufacturing process can be performed separately from other solar-cell-manufacturing processes, which is advantageous for mass production and large-area application.

Classes IPC  ?

• H01G 9/20 - Dispositifs photosensibles
• H01G 9/00 - Condensateurs électrolytiques, redresseurs électrolytiques, détecteurs électrolytiques, dispositifs de commutation électrolytiques, dispositifs électrolytiques photosensibles ou sensibles à la températureProcédés pour leur fabrication
• H01G 9/042 - Électrodes caractérisées par le matériau

Abrégé

The present disclosure relates to a color change dye prepared by impregnating hollow silica with a dye having a cationic dye and an anionic dye prepared using ion pairing, a sensor for detecting gas containing the above dye and a method for preparing the same, and more specifically to, a sensor that increases sensitivity and stability by increasing the area where the dye touches the gas and protecting the dye itself, since cationic dyes and anionic dyes are ion-paired to increase humidity resistance and react only with a trace amount of acetone. and the ion-paired dyes are then impregnated into hollow silica, and a method for preparing the same.

Classes IPC  ?

• G01N 21/29 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection visuelle
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes

Abrégé

A memory device accessed by circuits operating based on a first supply voltage. The memory device includes a cell array electrically connected to a plurality of word lines and a plurality of bit lines; a row driver configured to select one word line of the plurality of word lines based on a row address; a precharge circuit configured to precharge the plurality of bit lines based on the first supply voltage; a column driver configured to select at least one bit line of the plurality of bit lines based on a column address; and a read circuit configured to read data stored in the cell array through the at least one bit line. The cell array, the row driver, the column driver, and the read circuit operate based on a second supply voltage, which is higher than the first supply voltage.

Classes IPC  ?

• G11C 11/419 - Circuits de lecture-écriture [R-W]
• G11C 11/418 - Circuits d'adressage

Abrégé

The present invention relates to a facial image-based method for providing information about a headache, and an apparatus using same, wherein the facial image-based method, which is implemented by a processor, comprises the steps of: receiving facial image data from a user device; determining landmark-identified facial image data with the facial image data as input, by using a landmark identification model configured to output the landmark-identified facial image data with the facial image data as input; and determining user headache data with the landmark-identified facial image data as input, by using a headache determination model configured to output the user headache data with the landmark-identified facial image data as input.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition

Abrégé

A composition and method according to the present invention may be very effectively used to diagnose malignant gastric cancer and predict the prognosis of gastric cancer.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

A wearable electronic device is provided. The wearable electronic device includes a housing, a printed circuit board disposed inside the housing and including wireless communication circuitry and a ground part, and an antenna disposed inside the housing and electrically connected to the wireless communication circuitry, wherein the antenna includes a conductive pattern, a feeding member electrically connected to the wireless communication circuitry through a feeding point and configured to electrically connect a first point of the conductive pattern and a first point of the ground part, a short-circuit member configured to electrically connect a second point of the conductive pattern and a second point of the ground part, and a capacitive loading member disposed between the feeding member and the short-circuit member having a first part operatively coupled to a third point of the conductive pattern and a second part electrically connected to a third point of the ground part.

Classes IPC  ?

• H01Q 7/00 - Cadres ayant une distribution du courant sensiblement uniforme et un diagramme de rayonnement directif perpendiculaire au plan du cadre
• H01Q 1/22 - SupportsMoyens de montage par association structurale avec d'autres équipements ou objets
• H01Q 1/27 - Adaptation pour l'utilisation dans ou sur les corps mobiles
• H01Q 5/25 - Systèmes à ultralarge bande, p. ex. systèmes à résonnance multipleSystèmes à impulsions

Abrégé

Proposed are a phlegm suction alarm issuing apparatus and a method for a tracheostomy patient which monitor and analyze a respiratory sound of the tracheostomy patient in real time, then check congestion of phlegm, and issue a phlegm suction alarm.

Classes IPC  ?

• A61M 16/04 - Tubes trachéaux
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires

Abrégé

This vest-type speaker device comprises: a communication unit; at least one speaker positioned corresponding to the user's lung; a memory; and a processor for controlling the operation of a battery, wherein the processor is configured to receive a control signal based on user condition information from an external electronic device through the communication unit, and output sound waves and vibrations through the at least one speaker on the basis of the control signal.

Classes IPC  ?

• A61H 23/02 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement électrique ou magnétique
• A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
• H04R 1/32 - Dispositions pour obtenir la fréquence désirée ou les caractéristiques directionnelles pour obtenir la caractéristique directionnelle désirée uniquement
• G06N 3/08 - Méthodes d'apprentissage
• A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61B 6/03 - Tomographie informatisée

Abrégé

The present invention relates to a forearm fixing apparatus for a therapeutic robot for restoring and maintaining the range of motion of joints of an upper extremity, comprising: a fixing unit in which the forearm of a user is fixed to one surface thereof; a handle that is provided to be inclined on one surface of the fixing unit and gripped by a hand of the user; a plurality of frames provided at intervals on the other surface of the fixing unit; and a connector that is detachably coupled to any one of the plurality of frames and provided on a robot arm.

Classes IPC  ?

• A61H 1/02 - Appareils d'exercice extenseurs ou de ployage
• B25J 18/00 - Bras

Abrégé

The present invention relates to a method for prevention, alleviation, or treatment of cancer patients, especially epithelial mesenchymal transition (EMP)-subtype cancer patients. If PHGDH, SHMT and MTHFD2 inhibitors are co-administered to patients with cancer in which the expression level of a glutaminase (GLS) gene or a protein encoded thereby has increased, 1C metabolism is more effectively inhibited such that there is a synergistic effect on the inhibition of cancer cell proliferation in patients with refractory cancer that is difficult to treat because of recurrence, metastasis, and anticancer drug resistance, thereby enabling cancer to be very effectively treated. In addition, the expression level of the GLS gene or protein encoded thereby is measured so that information related to customized treatment methods from initial stages is provided to each patient and the success of treatment can be increased.

Classes IPC  ?

• A61K 31/501 - PyridazinesPyridazines hydrogénées non condensées et contenant d'autres hétérocycles
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61P 35/00 - Agents anticancéreux
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention relates to a composition for treating inflammatory diseases comprising germanium telluride nanosheets coated with polyvinylpyrrolidone, and the nanosheets have excellent anti-inflammatory and thus are excellent in treating inflammatory bowel disease and psoriasis.

Classes IPC  ?

• A61K 33/24 - Métaux lourdsLeurs composés
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/28 - DragéesPilules ou comprimés avec revêtements
• A61K 9/51 - Nanocapsules
• A61K 33/00 - Préparations médicinales contenant des ingrédients actifs inorganiques
• A61K 33/04 - Soufre, sélénium ou tellureLeurs composés
• A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques

Abrégé

Provided is a gold-doped nickel nanocluster having a specific number of gold atoms, nickel atoms, and organothiol-based ligands. The gold atoms, the nickel atoms, and the organothiol-based ligands are bonded in a specific structure, a method for manufacturing the same, an electrode for converting carbon dioxide including the same, and a method for converting carbon dioxide using the same.

Classes IPC  ?

• C25B 11/095 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques au moins un des composés est de type organique
• C25B 3/26 - Réduction du dioxyde de carbone

Abrégé

The present invention relates to a gas turbine blade having a shelf squealer tip, the gas turbine blade including an airfoil-shaped blade housing, and a squealer tip extending from an edge portion of a tip surface that is an end surface of the blade housing, in which the squealer tip is formed only on a part of the edge portion of the tip surface. According to the present invention, it is possible to maximize film-cooling performance on the tip surface and additionally reduce an aerodynamic loss by suppressing high-temperature main flow reattachment and swirl flow generation on the tip surface.

Classes IPC  ?

• F01D 5/20 - Extrémités de pales spécialement façonnées en vue d'obturer l'espace entre ces extrémités et le stator
• F01D 5/14 - Forme ou structure
• F01D 5/18 - Aubes creusesDispositifs de chauffage, de protection contre l'échauffement ou de refroidissement des aubes