Produits et services

Immunoassay reagents for medical use; diagnostic preparations for medical purposes; diagnostic reagents for medical use; diagnostic substances for medical use; reagents for blood grouping [for medical purposes].

Produits et services

Immunoassay reagents for medical use, diagnostic agents for medical use, diagnostic reagents for medical use, diagnostic substances for medical use, Reagents for blood grouping [for medical purposes

Produits et services

Immunoassay reagents for medical use, Serums for medical purposes, Reagents for medical use, Diagnostic preparations for medical purposes, Diagnostic reagents for medical use, Biochemical preparations for medical use, Biological reagents for medical use, Diagnostic substances for medical use, Reagents for blood grouping [for medical purposes]. Immunodetection services for medical purposes.

Abrégé

Tissue for use as a transplant, which tissue is allogeneic or xenogeneic and respectively the tissue may express an MHC I molecule that is immunologically incompatible to the transplant recipient and/or may express an MHC II molecule immunologically incompatible to the transplant recipient. The tissue suitable for use as a transplant and the method for its production include a genetic alteration of the tissue that provides for immunologic compatibility of the tissue with a transplant recipient. In the tissue for use as a transplant, which tissue expresses allogeneic or xenogeneic MHC I and/or allogeneic or xenogeneic MHC II molecules, the expression of the allogeneic or xenogeneic MHC I is downregulated by at least 50% to up to 90%, preferably the expression of the allogeneic or xenogeneic MHC I is downregulated by at least 60%.

Classes IPC  ?

• A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

Modified MHC I molecules that can be expressed in cell culture and can be more stable than natural MHC I molecules. An analytical process uses the modified MHC I molecules, e.g. for determination of antibodies in a serum sample directed against these MHC I molecules. MHC I is provided which has at least one covalent bond formed between a Cystein in the alpha chain and a Cystein in the β2-microglobulin.

Classes IPC  ?

• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]

Produits et services

Biological reagents for medical use; Biotechnological preparations for medical use; Diagnostic chemical reagents for medical use; Chemical reagents for medical or veterinary purposes; Chemical reagents for medical use; Chemical test reagents [medical]; Diagnostic preparations for medical or veterinary purposes; Diagnostic preparations for medical purposes; Diagnostic biomarker reagents for medical purposes; Diagnostic testing materials for medical use; Diagnostic reagents for medical use; Diagnostic substances for medical use; Albuminous preparations for medical purposes; Immunoassay reagents for medical use; In vitro diagnostic preparations for medical use; Indicators for medical diagnosis; Clinical medical reagents; Medical diagnostic test strips. Consultancy relating to biotechnology; Research relating to biotechnology; Research and development in the field of biotechnology. Medical diagnostic services.

Abrégé

The invention provides two newly identified blood group antigens (BGA), analytical processes for identifying the presence of the nucleotide sequence encoding these BGA and analytical processes for identifying these BGA proteins and an analytical process for identifying the presence of antibody directed against these BGA in a blood serum sample. The invention provides two allelic variants of SEQ ID NO: 1, also termed DACY and YCAD. These variants have been found to be BGA, which are epitopes that are recognized by serum antibodies, the BGA, or epitopes. These epitopes have been found to be functional, e.g. found to be recognized by serum antibodies which also recognize full-length CR1 protein in soluble form, e.g. lacking the transmembrane domain, as well as natural full-length CR1 membrane- bound on RBC or RBC membrane fragments.

Classes IPC  ?

• C07K 16/34 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des antigènes de groupes sanguins
• C12N 5/078 - Cellules du sang ou du système immunitaire
• G01N 33/80 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les groupes ou les types sanguins
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire

Abrégé

The present invention relates to modified MHC I molecules that can be expressed in cell culture and can be more stable than natural MHC I molecules. Further, the invention relates to analytical processes using the modified MHC I molecules, e.g. for determination of antibodies in a serum sample directed against these MHC I molecules. The invention provides MHC I which has at least one covalent bond formed between a Cystein in the alpha chain and a Cystein in the β2-microglobulin.

Classes IPC  ?

• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]

Produits et services

Biological reagents for medical use; Biotechnological preparations for medical use, namely, for genetic modification of cells, tissues and organs; Albuminous preparations for medical purposes; Clinical medical reagents for therapeutical use

Produits et services

Biological reagents for medical use; Biotechnological preparations for medical use; Diagnostic chemical reagents for medical use; Diagnostic chemical reagents for medical use; Chemical reagents for medical or veterinary purposes; Chemical reagents for medical use; Chemical test reagents [medical]; Diagnostic preparations for medical or veterinary purposes; Diagnostic preparations; Diagnostic biomarker reagents for medical purposes; Diagnostic testing materials for medical use; Diagnostic reagents for medical use; Diagnostic substances for medical use; Albuminous preparations for medical purposes; Immunoassay reagents for medical use; In vitro diagnostic preparations for medical use; Indicators for medical diagnosis; Clinical medical reagents; Medical diagnostic test strips. Consultancy relating to biotechnology; Research relating to biotechnology; Research and development in the field of biotechnology. Medical diagnostic services.

Abrégé

An analytical process for detecting antibody in human blood serum, which antibody is directed against blood group antigen, wherein the serum contains an additional antibody directed against a surface antigen, by contacting the serum to be analysed with blood cell membranes, which naturally bear surface blood group antigens, followed by detection of agglutination which indicated the presence of antibody directed against at least one surface antigen of the blood cell membranes. The agglutination reaction caused by the additional antibody is prevented, allowing the detection of anti-blood group antibody.

Classes IPC  ?

• G01N 33/80 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les groupes ou les types sanguins
• G01N 33/555 - Globule rouge
• G01N 33/541 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec séparation du complexe immunologique de l'antigène ou de l'anticorps non liés faisant intervenir un réactif de précipitation faisant intervenir un double ou un deuxième anticorps
• G01N 33/563 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet faisant intervenir des fragments d'anticorps
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

An analytical process for detecting antibody in human blood serum, which antibody is directed against blood group antigen, wherein the serum contains an additional antibody directed against a surface antigen, by contacting the serum to be analysed with blood cell membranes, which naturally bear surface blood group antigens, followed by detection of agglutination which indicated the presence of antibody directed against at least one surface antigen of the blood cell membranes. The agglutination reaction caused by the additional antibody is prevented, allowing the detection of anti-blood group antibody.

Classes IPC  ?

• G01N 33/80 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les groupes ou les types sanguins