The application relates to recombinant polypeptides having berberine bridge enzyme (BBE) activity that are derived from microorganisms, such as Phytohabitans sufuscus, Streptomyces sp. AJS327, Streptomyces varsoviensis, Actinomadura pelletieri, Streptomyces flaveolus, Streptomyces sp. Ru71. or Streptomyces sp. CNH287, and the use of these recombinant polypeptides in compositions and methods for the oxidative cyclization of prenylated compounds, such as CBGA, in carrying out the biosynthesis, including cell-free biosynthesis, of cyclized cannabinoid compounds, such as CBCA, THCA, and CBDA.
C07D 311/70 - Benzo [b] pyrannes non hydrogénés dans le carbocycle avec des substituants autres que des atomes d'oxygène ou de soufre en position 2 ou 4 avec deux radicaux hydrocarbonés liés en position 2 et des éléments autres que le carbone et l'hydrogène en position 6
C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12P 17/06 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'oxygène comme unique hétéro-atome du cycle contenant un hétérocycle à six chaînons, p. ex. fluorescéine
2.
BIOSYNTHESIS OF CYCLOLAVANDULYL DERIVATIVES OF AROMATIC COMPOUNDS
The present disclosure relates to compositions comprising cyclolavandulyl derivatives of aromatic compounds, such as cannabinoids, flavonoids, and alkaloids, and methods for preparing and using the compositions.
C12P 17/06 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'oxygène comme unique hétéro-atome du cycle contenant un hétérocycle à six chaînons, p. ex. fluorescéine
3.
IN SITU NADP BIOSYNTHESIS PROCESS FOR BIOBASED CHEMICAL PRODUCTION
The present disclosure relates to multi-enzyme pathways for the in situ generation of the cofactor NADP from lower-cost reagents, such as nicotinate, NMN (nicotinamide mononucleotide), and NAD (nicotinamide adenine dinucleotide), and the use of these pathways in NADP-dependent cell-free systems for the biobased production of chemicals, such as isobutanol.
Systems and methods for prenylation and recombinant pathways for the production of compounds, cannabinoids, cannabinoid precursors, and other prenylated chemicals in a cell free system. The present invention further includes enzymes and recombinant microorganisms that catalyze the reaction. The compounds, cannabinoids, cannabinoid precursors, and other prenylated chemicals are operable to be substituted with at least one deuterium, at least one tritium, at least one halogen, at least one hydroxyl group, and/or at least one additional isotope.
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
C12P 17/18 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, p. ex. rifamycine
6.
BIOSYNTHESIS OF SUBSTITUTED COMPOUNDS AND CANNABINOIDS
Systems and methods for prenylation and recombinant pathways for the production of compounds, cannabinoids, cannabinoid precursors, and other prenylated chemicals in a cell free system. The present invention further includes enzymes and recombinant microorganisms that catalyze the reaction. The compounds, cannabinoids, cannabinoid precursors, and other prenylated chemicals are operable to be substituted with at least one deuterium, at least one tritium, at least one halogen, at least one hydroxyl group, and/or at least one additional isotope.
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
C12P 17/18 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, p. ex. rifamycine
7.
BIOSYNTHESIS OF CYCLOLAVANDULYL DERIVATIVES OF AROMATIC COMPOUNDS
The present disclosure relates to compositions comprising cyclolavandulyl derivatives of aromatic compounds, such as cannabinoids, flavonoids, and alkaloids, and methods for preparing and using the compositions.
The present disclosure relates to compositions comprising cyclolavandulyl derivatives of aromatic compounds, such as cannabinoids, flavonoids, and alkaloids, and methods for preparing and using the compositions.
The application relates to recombinant polypeptides having berberine bridge enzyme (BBE) activity that are derived from microorganisms, such as Phytohabitans sujfuscus,Streptomyces sp. AJS327, Streptomyces varsoviensis, Actinomadura pelletieri, Streptomyces flaveolus, Streptomyces sp. Ru71, or Streptomyces sp. CNH287, and the use of these recombinant polypeptides in com¬ positions and methods for the oxidative cyclization of prenylated compounds, such as CBGA, in carrying out the biosynthesis, including cell-free biosynthesis, of cyclized cannabinoid compounds, such as CBCA, THCA, and CBDA.
C07C 39/19 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons monocycliques avec une insaturation autre que celle du cycle aromatique contenant des liaisons doubles carbone-carbone sans liaison triple carbone-carbone
C07D 311/58 - Benzo [b] pyrannes non hydrogénés dans le carbocycle avec des substituants autres que des atomes d'oxygène ou de soufre en position 2 ou 4
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
C12Q 1/26 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une oxydoréductase
10.
RECOMBINANT POLYPEPTIDES WITH BERBERINE BRIDGE ENZYME ACTIVITY USEFUL FOR THE BIOSYNTHESIS OF CANNABINOIDS
, Phytohabitans suffuscusStreptomyces sp.Streptomyces varsoviensisActinomadura pelletieriStreptomyces flaveolusStreptomyces sp.Streptomyces sp.Streptomyces sp. CNH287, and the use of these recombinant polypeptides in compositions and methods for the oxidative cyclization of prenylated compounds, such as CBGA, in carrying out the biosynthesis, including cell-free biosynthesis, of cyclized cannabinoid compounds, such as CBCA, THCA, and CBDA.
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12Q 1/26 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une oxydoréductase
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
C07D 311/58 - Benzo [b] pyrannes non hydrogénés dans le carbocycle avec des substituants autres que des atomes d'oxygène ou de soufre en position 2 ou 4
C07C 39/19 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons monocycliques avec une insaturation autre que celle du cycle aromatique contenant des liaisons doubles carbone-carbone sans liaison triple carbone-carbone
11.
Prenyltransferase variants with increased thermostability
The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids.
The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids.
The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids.
The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
04 - Huiles et graisses industrielles; lubrifiants; combustibles
05 - Produits pharmaceutiques, vétérinaires et hygièniques
30 - Aliments de base, thé, café, pâtisseries et confiseries
Produits et services
Fragrances; terpenes for use in essential oils Biofuels; fuels, biofuels and biodiesels based on energy-producing organic compounds, namely, terpenes, isoprenoids, alcohols, fatty acids, esters, alkanes, and alkenes Pharmaceuticals, namely, alcohols, esters, alkaloids, polyketides, steroids, isoprenoids, and non-ribosomal peptides, for use the treatment of pain, neuropathic pain, cancer pain, oncology, cancer symptoms, psychiatric illnesses, neurodegenerative diseases, multiple sclerosis, spinal cord injury, bladder disfunction, peripheral neuropathy, spasticity, perioperative pain, rheumatoid arthritis, inflammatory bowel disease, ulcerative colitis, hypoxic-ischaemic encephalopathy, symptoms of neurogenic disorders, movement disorders, essential tremors, psychotic disorders, diseases of the central nervous system, stroke and head injuries, motion sickness and chemically induced sickness, post-traumatic stress disorder, obesity, obesity associated with Type II Diabetes, bulimia, schizophrenia, Crohn's disease, Alzheimer's disease, bone disorders, inflammatory disorders, sleep and sleep disorders, and drug, alcohol, and nicotine abuse, epilepsy, convulsions, seizures, Dravet syndrome, Lennox-Gastaut syndrome, intractable childhood epilepsy with generalized tonic-clonic seizures, generalized epilepsy with febrile seizures plus, Doose syndrome, chromosome disorders, and metabolic disorders; anti-inflammatories; analgesics; nutraceuticals for use as a dietary supplement; dietary and nutritional supplements; none of the foregoing containing CBD, cannabinoids or tryptamines Flavor enhancers for use in food and beverage products
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Organic compounds for use in biotechnological and manufacturing processes and product development; organic compounds for use in the biochemical and chemical industries; organic compounds, namely, alcohols, fatty acids, esters, alkanes, alkenes, organic acids, indoles, flavonoids, flavonoids, polyketides, carotenoids, non-ribosomal peptides, lactones, aldehydes, alkaloids, isoprenoids, insect hormones, and plant hormones, for use in biotechnological manufacturing processes; organic compounds for use in biochemical and chemical industries, namely, pharmaceutical, energy, biofuel, food, beverage, dietary, nutritional, nutraceutical, flavor, fragrance, insect control, and agrochemical industries; organic compounds for use in the manufacture of biofuels; organic compounds for use in the manufacture of dietary and nutritional supplements; organic compounds for use in the manufacture of food and beverage products; none of the foregoing containing CBD, cannabinoids or tryptamines
