Polycationic ingredients for use in improving the efficacy of known organic acid compositions at neutral to basic pH, and/or reducing the amount of organic acids needed for antimicrobial activity. Methods of boosting antimicrobial activity of organic acid compositions is achieved through adding a polycationic compound. Use of the antimicrobial compositions in products is also described.
Polycationic ingredients for use in improving the efficacy of known organic acid compositions at neutral to basic pH, and/or reducing the amount of organic acids needed for antimicrobial activity. Methods of boosting antimicrobial activity of organic acid compositions is achieved through adding a polycationic compound. Use of the antimicrobial compositions in products is also described.
Polycationic ingredients for use in improving the antimicrobial efficacy of known organic acid compositions at neutral to basic pH, and/or reducing the amount of organic acids needed for antimicrobial activity. Methods of boosting antimicrobial activity of organic acid compositions is achieved through adding a polycationic compound. Use of the antimicrobial compositions in products is also described.
A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
A01N 37/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant au moins un groupe carboxylique ou un thio-analogue, ou d'un de leurs dérivés, et un atome d'oxygène ou de soufre lié par une liaison simple, liés au même squelette carboné, cet atome d'oxygène ou de soufre ne faisant pas partie d'un groupe carboxylique ou d'un thio-analogue, ou d'une de leurs dérivés, p. ex. acides hydroxycarboxyliques contenant au moins un atome d'oxygène ou de soufre lié à un système cyclique aromatique contenant au moins un groupe carboxylique ou un thio-analogue, ou un de leurs dérivés, et un atome d'oxygène ou de soufre liés au même système cyclique aromatique
A01N 37/44 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant au moins un groupe carboxylique ou un thio-analogue, ou un de leurs dérivés, et un atome d'azote lié au même squelette carboné par une liaison simple ou double, cet atome d'azote ne faisant pas partie d'un dérivé ou d'un thio-analogue d'un groupe carboxylique, p. ex. acides aminocarboxyliques
5.
Preservative Compositions and Methods of Use Thereof
Antimicrobial preservative compositions that can be incorporated in products to be preserved are disclosed herein. The disclosed compositions include immobilized biocidal enzymes, such as cross-linking enzymes or active enzymes falling into the zymogen-class, for the purpose of modifying amino acid residues on a protein or binding a molecule of interest to a protein. The compositions include enzymes that are immobilized on a polymeric solid support, which improve the shelf life of the enzyme and protect the enzyme from auto-cross-linking or other deterioration over extended storage periods. Also disclosed are methods of increasing the self-like of products, such as personal care, household and industrial products, by incorporating an effective amount of the disclosed compositions into the product.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Chemical preservative compositions for use in the manufacture of personal care products, household products, and food; Chemical preservatives for use in the production of a wide variety of chemicals
7.
SUNSCREEN COMPOSITIONS COMPRISING IMINE ANALOGS OF A SUNSCREEN COMPRISING A KETONE
Sunscreen compositions and sunscreen active ingredients are disclosed herein which comprise at least one ketone-containing UV filter and at least one primary or secondary amine wherein at least one ketone-containing UV filter and at least one primary or secondary amine react to form an imine analog of the ketone-containing UV filter wherein the imine analog has at least one property selected from the group consisting of a) is capable of extending UV protection into a visible region equal to or greater than 400 nm, b) is water resistant, and/or c) prevents or decreases skin penetration. This imine analog may be further modified to provide a substrate capable of reacting with transglutaminase or any variant thereof and/or a lysyl oxidase to bind the sunscreen composition or sunscreen active ingredient to a target of interest. Also disclosed are cosmetic or pharmaceutical preparations comprising any of the sunscreen compositions or sunscreen ingredients along with a cosmetically or pharmaceutically acceptable carrier.
Transglutaminase variants with, inter alia, improved chemostability and/or productivity are disclosed herein. Uses of wild-type transglutaminase and transglutaminase variants are also disclosed herein.
A61Q 5/00 - Préparations pour les soins des cheveux
C07K 14/36 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant d'ActinomycesPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Streptomyces (G)
C14C 9/00 - Imprégnation du cuir en vue de sa conservation, de son imperméabilisation, pour le rendre résistant à la chaleur ou en vue de buts similaires
D06M 16/00 - Traitement biochimique des fibres, fils, filés, tissus ou articles fibreux faits de ces matières, p. ex. enzymatique
D06P 5/00 - Autres caractéristiques de la teinture ou de l'impression des textiles ou de la teinture du cuir, des fourrures ou des substances macromoléculaires de toutes formes
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
17 - Produits en caoutchouc ou en matières plastiques; matières à calfeutrer et à isoler
Produits et services
Enzyme and formulations of enzymes for industrial purposes and in the manufacture of commercial and industrial goods; enzymes for use in leather and textile industry, namely, bonding blends of chemicals and hydrolyzed proteins and/or peptides; enzymes for scientific and research purposes; enzymes derived from biotechnological processes for use in industry; adhesives, namely, protein or peptide-based adhesives for use in industry, namely, for use in manufacture of carpet backing; plastics, unprocessed Adhesives, namely, protein or peptide-based adhesives for use in packaging, other than stationery and not for medical or household purposes
10.
IMMOBILIZED PROTEASES FOR ACTIVATION OF THE ZYMOGEN FORM OF TRANSGLUTAMINASE
H01M 8/1062 - Matériaux d’électrolyte polymère caractérisés par un support poreux n’ayant pas de propriétés conductrices ioniques caractérisés par les propriétés physiques du support poreux, p. ex. sa porosité ou son épaisseur
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Enzyme preparations for use in the manufacture of cosmetics and personal care products; enzymes and polymer formulations of enzymes for industrial purposes and in the manufacture of commercial and industrial goods; enzymes for use in the manufacture of cosmetics; enzymes for use in the manufacture of personal care products, sunscreens, soaps, shampoos, cleansers, body wash preparations, skin moisturizers and lotions; enzymes for bonding of dyes and pigments to skin, hair, nails; enzymes for scientific and research purposes; enzymes for hair styling protection
Enzyme-based compositions for broad spectrum microbial control and/or preservation are disclosed herein. The disclosed compositions include crosslinking enzymes, optionally, in the form of a zymogen, and include antimicrobial peptides, proteins, polymers, and optionally may include chemical preservatives.
Variants of the transglutaminase enzyme of Streptomyces mobaraensis are provided. The disclosed variants exhibit at least about 2-fold increased enzymatic activity versus the wild-type enzyme. Methods and compositions are provided for biocidal applications of use and for covalently binding small organic molecules to a protein or material of interest. Methods are provided for increasing the self-life of products, such as personal care, household and industrial products, by incorporating an effective amount of the disclosed variant enzymes into the product. The transglutaminase variants may also be used to covalently bind functional ingredients, such as UV-blocking molecules, dyes, or pigments to proteins. The transglutaminase enzymes and functional ingredients may be incorporated into a cosmetic formulation for modifying skin, hair, or nail proteins or skin-derived proteins, such as collagen, keratin, and/or elastin.
Transglutaminase variants are disclosed. Applications of use for the variants, including use as preservatives, biocidal agents, and for modification of proteins, are disclosed.
Sunscreen compositions and sunscreen active ingredients are disclosed herein which comprise at least one ketone-containing UV filter and at least one primary or secondary amine wherein at least one ketone-containing UV filter and at least one primary or secondary amine react to form an imine analog of the ketone-containing UV filter wherein the imine analog has at least one property selected from the group consisting of a) is capable of extending UV protection into a visible region equal to or greater than 400 nm, b) is water resistant, and/or c) prevents or decreases skin penetration. This imine analog may be further modified to provide a substrate capable of reacting with transglutaminase or any variant thereof and/or a lysyl oxidase to bind the sunscreen composition or sunscreen active ingredient to a target of interest. Also disclosed are cosmetic or pharmaceutical preparations comprising any of the sunscreen compositions or sunscreen ingredients along with a cosmetically or pharmaceutically acceptable carrier.
A61K 8/46 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du soufre
A61Q 17/04 - Préparations topiques pour faire écran au soleil ou aux radiationsPréparations topiques pour bronzer
High throughput cell free protein synthesis methods and systems are provided for expression of active, mature enzymes and proteins derived from zymogens and proproteins. Zymogens and proproteins are expressed in their mature, active form in a cell free expression system, without cleavage of a pro-sequence to produce the active polypeptide.
Methods for activating zymogens of transglutaminases involving the use of at least one immobilized protease are disclosed as well as activated transglutaminases made by such methods.
Sunscreen compositions and sunscreen active ingredients are disclosed herein which comprise at least one ketone-containing UV filter and at least one primary or secondary amine wherein at least one ketone-containing UV filter and at least one primary or secondary amine react to form an imine analog of the ketone-containing UV filter wherein the imine analog has at least one property selected from the group consisting of a) is capable of extending UV protection into a visible region equal to or greater than 400 nm, b) is water resistant, and/or c) prevents or decreases skin penetration. This imine analog may be further modified to provide a substrate capable of reacting with transglutaminase or any variant thereof and/or a lysyl oxidase to bind the sunscreen composition or sunscreen active ingredient to a target of interest. Also disclosed are cosmetic or pharmaceutical preparations comprising any of the sunscreen compositions or sunscreen ingredients along with a cosmetically or pharmaceutically acceptable carrier.
A61K 8/40 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant de l'azote
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
A61K 8/46 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du soufre
A61Q 17/04 - Préparations topiques pour faire écran au soleil ou aux radiationsPréparations topiques pour bronzer
Antimicrobial preservative compositions that can be incorporated in products to be preserved are disclosed herein. The disclosed compositions include immobilized biocidal enzymes, such as cross-linking enzymes or active enzymes falling into the zymogen-class, for the purpose of modifying amino acid residues on a protein or binding a molecule of interest to a protein. The compositions include enzymes that are immobilized on a polymeric solid support, which improve the shelf life of the enzyme and protect the enzyme from auto-cross-linking or other deterioration over extended storage periods. Also disclosed are methods of increasing the self-like of products, such as personal care, household and industrial products, by incorporating an effective amount of the disclosed compositions into the product.
Enzyme-based compositions for broad spectrum microbial control and/or preservation are disclosed herein. The disclosed compositions include crosslinking enzymes, optionally, in the form of a zymogen, and include antimicrobial peptides, proteins, polymers, and optionally may include chemical preservatives.
Variants of the transglutaminase enzyme of Streptomyces mobaraensis are provided. The disclosed variants exhibit at least about 2-fold increased enzymatic activity versus the wild-type enzyme. Methods and compositions are provided for biocidal applications of use and for covalently binding small organic molecules to a protein or material of interest. Methods are provided for increasing the self-life of products, such as personal care, household and industrial products, by incorporating an effective amount of the disclosed variant enzymes into the product. The transglutaminase variants may also be used to covalently bind functional ingredients, such as UV-blocking molecules, dyes, or pigments to proteins. The transglutaminase enzymes and functional ingredients may be incorporated into a cosmetic formulation for modifying skin, hair, or nail proteins or skin-derived proteins, such as collagen, keratin, and/or elastin.
Transglutaminase variants are disclosed. Applications of use for the variants, including use as preservatives, biocidal agents, and for modification of proteins, are disclosed.
High throughput cell free protein synthesis methods and systems are provided for expression of active, mature enzymes and proteins derived from zymogens and proproteins. Zymogens and proproteins are expressed in their mature, active form in a cell free expression system, without cleavage of a pro-sequence to produce the active polypeptide.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Enzymes and polymer formulations of enzymes for industrial purposes and in the manufacture of commercial and industrial goods; enzymes for use in the food industry; food preservatives; enzymes for use in replacing chemical biocidal, preservative, anti-bacterial, anti-fungal, and anti-viral preparations for industrial purposes and in the manufacture of commercial and industrial goods; enzymes for use in the manufacture of cosmetics; enzymes for use in the manufacture of personal care products, sunscreens, soaps, shampoos, cleansers, body wash preparations, skin moisturizers and lotions, mouthwashes, and toothpastes; enzymes for use in the textile industry and for tanning of leather; enzymes for bonding of dyes and pigments to skin, hair, nails, textiles, and leather; enzymes for scientific and research purposes; enzymes for manufacture of hair styling protection preparations; enzymes derived from biotechnological processes for use in industry; enzymes for use in agricultural products; preservatives for use in the manufacture of personal care products, sunscreens, soaps, shampoos, cleansers, body wash preparations, skin moisturizers and lotions, mouthwashes, and toothpastes; polymer compositions for use in the manufacture of commercial and industrial goods, and in the manufacture of food, cosmetic, sunscreen, personal care, soap, shampoo, cleanser, body wash, skin moisturizer and lotion, mouthwash, and toothpaste products; adhesives, namely, industrial adhesives and adhesives for use in manufacturing; latex adhesives for use in the manufacture of packaging and carpet backing; plastics, unprocessed
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Enzymes and polymer formulations of enzymes for industrial purposes and in the manufacture of commercial and industrial goods; enzymes for use in the food industry; food preservatives; enzymes for use in replacing chemical biocidal, preservative, anti-bacterial, anti-fungal, and anti-viral preparations for industrial purposes and in the manufacture of commercial and industrial goods; enzymes for use in the manufacture of cosmetics; enzymes for use in the manufacture of personal care products, sunscreens, soaps, shampoos, cleansers, body wash preparations, skin moisturizers and lotions, mouthwashes, and toothpastes; enzymes for use in the textile industry and for tanning of leather; enzymes for bonding of dyes and pigments to skin, hair, nails, textiles, and leather; enzymes for scientific and research purposes; enzymes for manufacture of hair styling protection preparations; enzymes derived from biotechnological processes for use in industry; enzymes for use in agricultural products; preservatives for use in the manufacture of personal care products, sunscreens, soaps, shampoos, cleansers, body wash preparations, skin moisturizers and lotions, mouthwashes, and toothpastes; polymer compositions for use in the manufacture of commercial and industrial goods, and in the manufacture of food, cosmetic, sunscreen, personal care, soap, shampoo, cleanser, body wash, skin moisturizer and lotion, mouthwash, and toothpaste products; adhesives, namely, industrial adhesives and adhesives for use in manufacturing; latex adhesives for use in the manufacture of packaging and carpet backing; plastics, unprocessed
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Enzymes and polymer formulations of enzymes for industrial purposes and in the manufacture of commercial and industrial goods; enzymes for use in the food industry; food preservatives; enzymes for use in replacing chemical biocidal, preservative, anti-bacterial, anti-fungal, and anti-viral preparations for industrial purposes and in the manufacture of commercial and industrial goods; enzymes for use in the manufacture of cosmetics; enzymes for use in the manufacture of personal care products, sunscreens, soaps, shampoos, cleansers, body wash preparations, skin moisturizers and lotions, mouthwashes, and toothpastes; enzymes for use in the textile industry and for tanning of leather; enzymes for bonding of dyes and pigments to skin, hair, nails, textiles, and leather; enzymes for scientific and research purposes; enzymes for manufacture of hair styling protection preparations; enzymes derived from biotechnological processes for use in industry; enzymes for use in agricultural products; preservatives for use in the manufacture of personal care products, sunscreens, soaps, shampoos, cleansers, body wash preparations, skin moisturizers and lotions, mouthwashes, and toothpastes; polymer compositions for use in the manufacture of commercial and industrial goods, and in the manufacture of food, cosmetic, sunscreen, personal care, soap, shampoo, cleanser, body wash, skin moisturizer and lotion, mouthwash, and toothpaste products; adhesives, namely, industrial adhesives and adhesives for use in manufacturing; latex adhesives for use in the manufacture of packaging and carpet backing; plastics, unprocessed Scientific research in the field of biotechnology, protein engineering, enzyme engineering, and enzyme formulations for commercial, industrial, pharmaceutical, biocidal, antimicrobial, antibacterial, antiviral, and antifungal uses and for the manufacture of commercial, industrial, pharmaceutical, biocidal, antimicrobial, antibacterial, antiviral, and antifungal products; scientific research in the field of enzymes for incorporation into preservative, cosmetic, food, sunscreen, and personal care products
31.
PRESERVATIVE COMPOSITIONS AND METHODS OF USE THEREOF
Antimicrobial preservative compositions that can be incorporated in products to be preserved are disclosed herein. The disclosed compositions include immobilized biocidal enzymes, such as cross-linking enzymes or active enzymes falling into the zymogen-class, for the purpose of modifying amino acid residues on a protein or binding a molecule of interest to a protein. The compositions include enzymes that are immobilized on a polymeric solid support, which improve the shelf life of the enzyme and protect the enzyme from auto-cross-linking or other deterioration over extended storage periods. Also disclosed are methods of increasing the self-like of products, such as personal care, household and industrial products, by incorporating an effective amount of the disclosed compositions into the product.
A01N 25/22 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles contenant des ingrédients stabilisant les ingrédients actifs
