Disclosed are a compound as shown by formula I or a pharmaceutically acceptable salt or a nano micelle thereof, and a preparation method and use thereof. The structure of the compound comprises an amphipathic block polymer and a Tanshinone I compound. Also disclosed is a use of the compound or a pharmaceutically acceptable salt or a nano micelle thereof in the preparation of an antitumor drug.
C08G 65/30 - Traitement de post-polymérisation, p. ex. obtention, purification, séchage
C08F 283/02 - Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères prévus par la sous-classe sur des polycarbonates ou des polyesters saturés
The invention belongs to the field of medicine and pharmaceutical chemistry, and particularly relates to a novel anti-tumor drug composition, especially a drug composition of bisbenzylisoquinoline alkaloids (such as, berbamine and tetrandrine) and anthracycline compounds (such as, Aclacinomycin A), and its use for treating tumors.
A61K 31/4748 - QuinoléinesIsoquinoléines formant une partie de systèmes cycliques pontés
A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine liés à un système carbocyclique condensé, p. ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
The invention belongs to the field of medicine and pharmaceutical chemistry, and particularly relates to a novel anti-tumor drug composition, especially a drug composition of bisbenzylisoquinoline alkaloids (such as, berbamine and tetrandrine) and imatinib mesylate, and its use for treating tumors.
The present invention belongs to the field of natural medicine and pharmaceutical chemistry. Provided are novel derivatives of paridis saponins I with 5'-acylated arabinofuranosyl group, or pharmaceutically acceptable salts thereof. Also provided are the method for preparing the compounds, the pharmaceutical composition comprising these compounds, and their application for preparing anti-tumor medicament.
C07J 71/00 - Stéroïdes ayant le squelette du cyclopenta[a]hydrophénanthrène condensé avec un hétérocycle
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
The present invention belongs to the fields of natural medicine and medicinal chemistry, and in particular relates to a new-type 7-substituted Hanfangichin B derivative of general formula (I) or pharmaceutically acceptable adducts, composites and salts thereof, a method of preparing the compounds, a pharmaceutical composition containing same and the use thereof in preparing anti-tumour medicines.
The present invention relates to the fields of natural medicine and medicinal chemistry, and more particularly to a 1-oxo/acylation-14-acylated oridonin derivative of a general formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the compounds, a pharmaceutical composition comprising the compounds, and application thereof in preparation of antitumor drugs.
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
The present invention relates to the field of natural drugs and pharmaceutical chemistry, and more particularly to novel 2-aminated methylene or 2-esterified methylene tanshinone I derivatives of a general formula I or pharmaceutically acceptable salts thereof, a method for preparing such compounds, a pharmaceutical composition containing the compound, and a use thereof in preparation of antitumor drugs. In the formula I, when X is nitrogen, the derivative is 2-aminated methylene tanshinone I. When X is oxygen, the derivative is 2-esterified methylene tanshinone I.
C07D 307/77 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle condensés en ortho ou en péri avec des carbocycles ou avec des systèmes carbocycliques
A61K 31/343 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à cinq chaînons avec un oxygène comme seul hétéro-atome d'un cycle, p. ex. isosorbide condensés avec un carbocycle, p. ex. coumarane, bufaralol, béfunolol, clobenfurol, amiodarone
The present invention belongs to the fields of natural medicine and medicinal chemistry, and relates particularly to new oleanolic acid amidate derivatives of general formula I or pharmaceutically acceptable salts thereof, preparation methods of these compounds, compositions including these compounds and uses for preparing antitumor medicine.
The present invention relates to the field of natural drugs and pharmaceutical chemistry, and more particularly to novel 2-alkyl-or-aryl-substituted tanshinone I derivatives of a general formula I or pharmaceutically acceptable salts thereof, a method for preparing such compounds, a pharmaceutical composition containing the compound, and a use thereof in preparation of antitumor drugs. When Z=R, the derivative is 2-alkyl-substituted tanshinone I. When Z=Ar, the derivative is 2-aryl-substituted tanshinone I. When Z=Het, the derivative is 2-heteroaryl-or-heterocyclyl-substituted tanshinone I.
C07D 307/77 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle condensés en ortho ou en péri avec des carbocycles ou avec des systèmes carbocycliques
A61K 31/343 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à cinq chaînons avec un oxygène comme seul hétéro-atome d'un cycle, p. ex. isosorbide condensés avec un carbocycle, p. ex. coumarane, bufaralol, béfunolol, clobenfurol, amiodarone
The present invention relates to the fields of natural medicaments and pharmaceutical chemistry, and relates specifically to, as represented by formula (I), a novel 2-substituted oleanolic acid derivative or a pharmaceutically acceptable salt thereof, a method for preparing the compounds, a pharmaceutical composition comprising the compounds, and use thereof in preparing an antitumor medicament.
The present invention relates to uses of berbamine or a pharmaceutically acceptable salt thereof as a pharmaceutical composition to treat chronic myeloid leukemia, in particular to the Imatinib tolerant chronic myeloid leukemia.
The present invention belongs to the field of natural medicine and medicinal chemistry, in particular relating to novel tetrandrine derivatives with substituted 5-carbon of general formula (I) or pharmaceutically acceptable adducts, complexes and salts thereof, to preparation methods therefor, to pharmaceutical compositions containing the compound, and to use thereof in preparing antitumour drugs.
The present invention relates to the fields of medicines and medicinal chemistry, and relates specifically to, as represented by Formula (I), a novel aminated derivative of homoharringtonine or a pharmaceutically acceptable salt thereof, a method for preparing said compounds, a pharmaceutical composition comprising the compound, and an application thereof in preparing an antitumor medicament.
C07D 491/02 - Composés hétérocycliques contenant dans le système cyclique condensé, à la fois un ou plusieurs cycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle, et un ou plusieurs cycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus dans les groupes , , ou dans lesquels le système condensé contient deux hétérocycles
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
The present invention relates to the fields of natural medicine and medicinal chemistry, and relates to, as represented by Formula (I) and Formula (II), a novel acylated derivative of homoharringtonine or a pharmaceutically acceptable salt thereof, a method for preparing said compounds, a pharmaceutical composition comprising the compound, and an application thereof in preparing an antitumor medicament.
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
Heterocyclic amino berbamine derivatives having formula (I) or their pharmaceutically acceptable salts, processes for preparing them, pharmaceutical compositions comprising them, and their use in manufacture of antitumor medicaments are provided.
The present invention relates to a novel diimidated derivative of berbamine of General Formula I, comprising, but not limited to, a phthalimidated derivative of berbamine, an aromatic heterocyclic dicarboximidated derivative of berbamine, or a pharmaceutically acceptable salt thereof, a method for preparing the compounds, a pharmaceutical composition comprising the compounds, and a use of the compounds in preparation of anti-tumor drugs.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
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