Hanall Pharmaceutical Company, Ltd.

République de Corée

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Classe IPC
A61K 9/22 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue 7
A61K 31/155 - Amidines (), p. ex. guanidine (H2N-C(=NH)-NH2), isourée (HN=C(OH)NH2), isothiourée (HN=C(SH)-NH2) 4
A61K 9/26 - Particules distinctes dans une matrice support 3
A61K 9/52 - Préparations en capsules, p. ex. de gélatine, de chocolat du type à libération prolongée ou discontinue 3
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques 2
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Résultats pour  brevets

1.

PHARMACEUTICAL FORMULATION FOR TREATING CARDIOVASCULAR DISEASE

      
Numéro d'application IB2009006277
Numéro de publication 2009/127974
Statut Délivré - en vigueur
Date de dépôt 2009-02-23
Date de publication 2009-10-22
Propriétaire HANALL PHARMACEUTICAL CO., LTD. (République de Corée)
Inventeur(s)
  • Kim, Sung, Wuk
  • Jun, Sung, Soo
  • Koo, Ja, Seong
  • Kim, Jin, Wook
  • Park, Sun, Woo
  • Jang, Seok, Young
  • Lee, Sang, Ju
  • Jo, Young, Gwan
  • Lee, Jun, Young

Abrégé

The present invention provides a pharmaceutical formulation comprising: an early release portion comprising as a pharmaceutical active ingredient a statin-based hypolipidic agent, an isomer thereof, or a pharmaceutically acceptable salt thereof; and a slow release portion comprising as a pharmaceutical active ingredient a dihydropyridine-based calcium channel blocking agent, an isomer thereof, or a pharmaceutically acceptable salt thereof. When compared with a single formulation of each of the drugs or a simple combination formulation of the drugs, the pharmaceutical formulation according to the present invention comprising an early release portion comprising a statin-based hypolipidic agent and a slow release portion comprising a dihydropyridine-based calcium channel blocking agent is pharmaceutically, scientifically, and economically very useful in preventing or treating cardiovascular disease, pulmonary heart disease, pulmonary disease, or kidney disease of patients who have a metabolic syndrome, insulin resistance, diabetes, or prediabetes. The formulation of the present invention is effective in preventing antagonistic and side effects between the drugs by making the dissolution rate of the statin-based hypolipidic agent different from that of the dihydropyridine-based calcium channel blocking agent, and in facilitating patient compliance in taking the drugs by administering the two different drugs simultaneously.

Classes IPC  ?

  • A61K 9/52 - Préparations en capsules, p. ex. de gélatine, de chocolat du type à libération prolongée ou discontinue
  • A61K 9/28 - DragéesPilules ou comprimés avec revêtements
  • A61K 9/22 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue
  • A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
  • A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
  • A61K 47/38 - CelluloseSes dérivés
  • A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
  • A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins

2.

PHARMACEUTICAL FORMULATION FOR TREATING CARDIOVASCULAR DISEASE

      
Numéro d'application IB2009000331
Numéro de publication 2009/127922
Statut Délivré - en vigueur
Date de dépôt 2009-02-23
Date de publication 2009-10-22
Propriétaire HANALL PHARMACEUTICAL CO., LTD. (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Koo, Ja Seong
  • Kim, Jin, Wook
  • Park, Sun Woo
  • Jang, Seok Young
  • Lee, Sang Ju
  • Jo, Young Gwan
  • Lee, Jun Young

Abrégé

The present invention provides a pharmaceutical formulation containing an immediate-release compartment and an extended-release compartment. The immediate-release compartment comprises a statin lipid-lowering drug, its isomer, or its pharmaceutically acceptable salt as a pharmacologically active ingredient and the extended-release compartment contains a dihydropyridine calcium channel blocker, its isomer, or its pharmaceutically acceptable salt as a pharmacologically active ingredient. The combined formulation of immediate-release, statin lipid-lowering drug and extended-release dihydropyridine calcium channel blocker, is pharmacologically, clinically, scientifically, and economically more useful than the single formulation of each of the drugs or a simple combination of the drugs, in preventing and treating cardiovascular disease, cardiopulmonary disease, pulmonary disease, or kidney disease in patients with metabolic syndrome and insulin resistance and patients with diabetes or suspected prediabetes. médicamentsThe formulation of the present invention allows different release times for the statin lipid-lowering drug and the dihydropyridine calcium channel blocker, and thus prevents mutual antagonism and side effects between the two drugs, and provides easy administration for patients simultaneously taking the two drugs simultaneously.

Classes IPC  ?

  • A61K 9/52 - Préparations en capsules, p. ex. de gélatine, de chocolat du type à libération prolongée ou discontinue
  • A61K 9/22 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue
  • A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
  • A61K 9/28 - DragéesPilules ou comprimés avec revêtements
  • A61K 47/38 - CelluloseSes dérivés
  • A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire

3.

PHARMACEUTICAL COMPOSITION FOR TREATING HEPATITIS C VIRUS INFECTION COMPRISING HMG-COA REDUCTASE INHIBITOR AND BILE ACID

      
Numéro d'application KR2008005965
Numéro de publication 2009/048289
Statut Délivré - en vigueur
Date de dépôt 2008-10-10
Date de publication 2009-04-16
Propriétaire HANALL PHARMACEUTICAL COMPANY. LTD (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja Seong
  • Lee, Jun Young

Abrégé

Disclosed herein is a pharmaceutical composition for treating hepatitis C virus infection comprising an HMG-CoA reductase inhibitor and bile acid. More specifically, disclosed are a pharmaceutical composition for treating hepatitis C vims infection comprising fluvastatin or a pharmaceutically acceptable salt thereof along with ursodeoxycholic acid and a preparation method thereof.

Classes IPC  ?

  • A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
  • A61K 31/231 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone ayant une ou deux doubles liaisons
  • A61K 31/57 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone
  • C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
  • A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
  • A61P 31/12 - Antiviraux

4.

N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE DICARBOXYLATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

      
Numéro d'application KR2008005574
Numéro de publication 2009/038396
Statut Délivré - en vigueur
Date de dépôt 2008-09-19
Date de publication 2009-03-26
Propriétaire HANALL PHARMACEUTICAL COMPANY. LTD (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja Seong
  • Kim, Young Woong
  • Kim, Byoung Ha
  • Kim, Duck

Abrégé

Disclosed herein are a novel dicarboxylic acid salt of N,N- dimethylimidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are a novel dicarboxylic acid salt of N,N- dimethylimidodicarbonimidic diamide, a crystalline acid addition salt prepared by allowing N,N-dimethylimidodicarbonimidic diamide to react with a specific dicarboxylic acid, which has improved physical and chemical properties including solubility, stability, non-hygroscopicity and anti-adhesive properties, and low toxicity, and thus is very effective in the prevention and treatment of not only diabetes and its complications in patients with so-called metabolic syndromes, in which diabetes, obesity, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndromes, etc. appear in combination, but also p53 gene-deficient cancers, muscular pain, muscle cytotoxicity and rhabdomyolysis, as well as a preparation method thereof and a pharmaceutical composition comprising the same.

Classes IPC  ?

  • C07C 279/26 - X et Y étant des atomes d'azote, c.-à-d. biguanides

5.

1,3,5-TRIAZINE-2,4,6-TRIAMINE COMPOUND OR PHARMACEUTICAL ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

      
Numéro d'application KR2008005062
Numéro de publication 2009/028891
Statut Délivré - en vigueur
Date de dépôt 2008-08-28
Date de publication 2009-03-05
Propriétaire
  • HANALL PHARMACEUTICAL COMPANY. LTD (République de Corée)
  • KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (République de Corée)
Inventeur(s)
  • Cheon, Hyae Gyeong
  • Kim, Kwang-Rok
  • Rhee, Sang Dal
  • Jung, Won Hoon
  • Lee, Jong-Cheol
  • Kim, Sung Wuk
  • Jun, Sung Soo

Abrégé

Disclosed herein are a 1,3,5-triazine-2,4,6-triamine compound or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for preventing or treating metabolic syndromes, diabetes, or cancers with deletion of P53 gene, which comprises the same.

Classes IPC  ?

6.

ORAL ADMINISTRATION DRUG COMPRISING CLOPIDOGREL BESYLATE

      
Numéro d'application KR2008005079
Numéro de publication 2009/028900
Statut Délivré - en vigueur
Date de dépôt 2008-08-29
Date de publication 2009-03-05
Propriétaire HANALL PHARMACEUTICAL CO., LTD. (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja Seong
  • Sun, Sang Ouk
  • Yu, Jin Hee

Abrégé

The present invention relates to clopidogrel besylate, and more specifically to a pharmaceutical drug for oral administration containing clopidogrel besylate as an active ingredient, which has superior therapeutic effects from the aspects of pharmacokinetics and pharmacodynamics and storage stability while eliminating difficulty in tableting step by wet granulation method adding a binding solution containing a low-grade alcohol during its manufacturing process, and a method of its preparation.

Classes IPC  ?

  • A61K 9/26 - Particules distinctes dans une matrice support
  • A61K 9/20 - Pilules, pastilles ou comprimés
  • A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
  • C07D 495/04 - Systèmes condensés en ortho
  • A61K 31/4743 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant le soufre comme hétéro-atome d'un cycle

7.

COMBINATION PREPARATION COMPRISING INHIBITOR OF HMG-COA REDUCTASE AND ASPIRIN AND METHOD FOR MANUFACTURING THE SAME

      
Numéro d'application KR2008004623
Numéro de publication 2009/022821
Statut Délivré - en vigueur
Date de dépôt 2008-08-08
Date de publication 2009-02-19
Propriétaire HANALL PHARMACEUTICAL COMPANY. LTD (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja Seong
  • Sun, Sang Ouk

Abrégé

The present invention relates to a chronotherapeutically combined pharmaceutical formulation for preventing and treating cardiovascular diseases, which is based on the principle of administering a plurality of drugs at certain time intervals (chronotherapy). Specifically, the combined pharmaceutical formulation comprises a HMG-CoA reductase inhibitor, such as simvastatin, and aspirin. Because the combined pharmaceutical formulation was developed based on the principle of administering drugs at certain time intervals, so-called chronotherapy, it shows an excellent effect of preventing or treating cardiovascular disease compared to those of the individual administration and simultaneous administration of the single preparations. Also, it is a once-daily dosage form which increases the medication compliance of patients. Particularly, even though the content of aspirin in the combined pharmaceutical formulation is reduced, the platelet aggregation inhibitory effect of aspirin in the combined pharmaceutical formulation is equal to that of the amount of aspirin used in the prior art, while the aspirin in the combined pharmaceutical formulation shows a antihypertensive effect. In addition, the chronotherapeutically combined pharmaceutical formulation allows the two drugs, which interact with each other, to be stored for a long period of time, and the combined pharmaceutical formulation ensures the human body-safety and efficacy of the two drugs.

Classes IPC  ?

  • A61K 31/35 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle

8.

N, N- DIMETHYL IMIDODICARBONIMIDIC DIAMIDE ACETATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

      
Numéro d'application KR2008000529
Numéro de publication 2008/093984
Statut Délivré - en vigueur
Date de dépôt 2008-01-29
Date de publication 2008-08-07
Propriétaire HANALL PHARMACEUTICAL COMPANY. LTD (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja Seong
  • Kim, Young Woong

Abrégé

The present invention relates to N,N -dimethyl imidodicarbonimidic diamide acetate, a method of preparing the same and a pharmaceutical composition comprising the same, and more particularly, to N,N-dimethyl imidodicarbonimidic diamide acetate which is a crystalline acid addition salt prepared by reacting N,N-dimethyl imidodicarbonimidic diamide with acetic acid, and which is very effective as a therapeutic agent for treating metabolic syndromes that glycosuria and diabetes mellitus, obesity, hyperlipidemia, fatty liver, coronary heart disease, osteoporosis, polycystic ovarian syndrome, a cancer depleted of gene P53, etc. are complexly occurred; treating diabetes mellitus and preventing its complication; and treating a cancer and preventing myalgia, muscle cell cytotoxicity and rhabdomyolysis, etc. since the acid addition salt is excellent in physicochemical properties such as solubility, stability, non-hygroscopicity, anti-adhering property, etc., and low toxicity, a method of preparing the same and a pharmaceutical composition comprising the same.

Classes IPC  ?

  • A61K 31/155 - Amidines (), p. ex. guanidine (H2N-C(=NH)-NH2), isourée (HN=C(OH)NH2), isothiourée (HN=C(SH)-NH2)

9.

CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION CONTAINING THIAZIDES AND ANGIOTENSIN-II-RECEPTOR BLOCKERS

      
Numéro d'application KR2007005403
Numéro de publication 2008/054121
Statut Délivré - en vigueur
Date de dépôt 2007-10-30
Date de publication 2008-05-08
Propriétaire HANALL PHARMACEUTICAL COMPANY. LTD (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja Seong
  • Kim, Jin Wook
  • Son, Jae Woon

Abrégé

Disclosed herein is a pharmaceutical composition, containing a thiazide compound and an angiotensin-II-receptor blocker, and a technology for formulating the same. More particularly, disclosed is a pharmaceutical combination formulation of thiazide compound and angiotensin-II-receptor blocker, which maximizes the pharmacological and clinical antihypertensive effects and complication preventive effects of the drugs and reduces the side effects of the drugs, compared to when single-component formulations of the drugs are administered simultaneously.

Classes IPC  ?

  • A61K 9/22 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue
  • A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
  • A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat

10.

CONTROLLED RELEASE COMPLEX COMPOSITION COMPRISING ANGIOTENSIN-II-RECEPTOR BLOCKERS AND HMG-COA REDUCTASE INHIBITORS

      
Numéro d'application KR2007005405
Numéro de publication 2008/054123
Statut Délivré - en vigueur
Date de dépôt 2007-10-30
Date de publication 2008-05-08
Propriétaire HANALL PHARMACEUTICAL COMPANY, LTD. (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja Seong
  • Son, Jae Woon

Abrégé

Disclosed herein is a lag time delayed-release combination pharmaceutical composition comprising of an angiotensin-II-receptor blocker and an HMG-CoA reductase inhibitor, as well as a preparation method thereof. The composition is designed based on chronotherapy in which active ingredients are administered to have different onset times, such that the release of each active ingredient of the composition in body can be lag time delayed to a specific rate. Also, the composition is very effective for the treatment of hypertension and the prevention of complications in patients having metabolic syndromes which show diabetes, obesity, hyperlipidemia, coronary artery diseases and the like. More specifically, the composition is a drug delivery system designed such that the release of each drug is controlled to a specific rate, and it can show the most ideal effect, when it is absorbed in body.

Classes IPC  ?

  • A61K 9/22 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue
  • A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
  • A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat

11.

COMBINATION FORMULATION WITH CONTROLLED RELEASE COMPRISING METFORMIN AND GLIMEPIRIDE

      
Numéro d'application KR2007005197
Numéro de publication 2008/050987
Statut Délivré - en vigueur
Date de dépôt 2007-10-23
Date de publication 2008-05-02
Propriétaire HANALL PHARMACEUTICAL CO., LTD. (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja-Seong
  • Jun, Yoon-Sik

Abrégé

The present invention relates to a controlled-release metformin-glimepiride combination formulation, and particularly to a controlled-release metformin- glimepiride combination formulation for oral administration, where a controlled- release layer is constructed so that the release of metformin having high water solubility and high unit dose may be maintained for 24 hours by selectively designing a release-controlling material and an immediate-release layer is constructed so that the content of glimepiride having low water solubility and low unit dose may be maintained uniform and it may also be immediately released. In particular, a controlled-release metformin-glimepiride combination formulation herein may be embodied into a multi-layered tablet, where a controlled-release layer and an immediate-release layer are separated to completely separate metformin and glimepiride so that excipients constructing the controlled-release layer may not affect an rapid release of glimepiride, thereby minimizing the interaction of drugs and maintaining the complementary activities of the drugs, thus being efficacious for especially type 2 diabetes.

Classes IPC  ?

  • A61K 9/24 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue en doses unitaires constituées de couches ou feuilletées
  • A61K 9/22 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue
  • A61K 31/155 - Amidines (), p. ex. guanidine (H2N-C(=NH)-NH2), isourée (HN=C(OH)NH2), isothiourée (HN=C(SH)-NH2)
  • A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques

12.

COMBINED PREPARATION FOR THE TREATMENT OF CARDIOVASCULAR DISEASES BASED ON CHRONOTHERAPY THEORY

      
Numéro d'application KR2007004929
Numéro de publication 2008/044862
Statut Délivré - en vigueur
Date de dépôt 2007-10-10
Date de publication 2008-04-17
Propriétaire HANALL PHARMACEUTICAL CO., LTD. (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja-Seong
  • Sun, Sang Ouk

Abrégé

The present invention relates to a functional combination preparation comprising a dihydropyridine-based calcium channel blocker such as amlodipine and an ARB (Angiotensin-2 receptor blocker) such as losartan. In particular, the present invention relates to a chronotherapeutical combination pharmaceutical formulations with controlled-release for the prevention or treatment of cardiovascular disease, which is formulated in accordance with xenobiotics and chronotherapy for enabling the two drugs to be chronotherapeutically released, thereby improving the therapeutic activity as compared to the co-administration of each drug in the form of a single pill, while reducing side effects and maintaining the therapeutic activity as high as possible at the time of day when the risk of a complication of cardiovascular disease is highest.

Classes IPC  ?

  • A61K 9/22 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue
  • A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
  • A61K 9/12 - AérosolsMousses
  • A61P 9/12 - Antihypertenseurs

13.

COMBINED PHARMECEUTICAL FORMULATION WITH CONTROLLED-RELEASE COMPRISING DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS AND HMG-COA REDUCTASE INHIBITORS

      
Numéro d'application KR2007000518
Numéro de publication 2008/023869
Statut Délivré - en vigueur
Date de dépôt 2007-01-30
Date de publication 2008-02-28
Propriétaire HANALL PHARMACEUTICAL CO., LTD. (République de Corée)
Inventeur(s)
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja-Seong
  • Kim, Jin Wook
  • Yim, Ju-Bin

Abrégé

The present invention relates to a combined pharmeceutical formulation, which is such designed that the release of each ingredient may be controlled to a predetermined release rate by applying the principle of the so-called chronotherapy, where drugs are administered in such a way that the activities of the drugs are expressed at intervals. The formulation of the present invention comprises statin-based lipid-lowering agent and dihydropyridine-based calcium channel blocker that affects cytochrome P450 enzyme as active ingredients, and is such constituted that the release rates of the aforementioned ingredients are different, thus preventing antagonism and side effects, while maintaining the synergistic effect, which leads to the convenience in medication.

Classes IPC  ?

  • A61K 31/4422 - 1,4-Dihydropyridines, p. ex. nifédipine, nicardipine
  • A61K 31/20 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique
  • A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil

14.

COMBINED PHARMACEUTICAL FORMULATION WITH CONTROLLED-RELEASE COMPRISING DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS AND HMG-COA REDUCTASE INHIBITORS

      
Numéro d'application KR2007004079
Numéro de publication 2008/023958
Statut Délivré - en vigueur
Date de dépôt 2007-08-24
Date de publication 2008-02-28
Propriétaire HANALL PHARMACEUTICAL CO., LTD. (République de Corée)
Inventeur(s)
  • Kim, Sung Wuk
  • Jun, Sung Soo
  • Jo, Young Gwan
  • Koo, Ja-Seong
  • Kim, Jin Wook

Abrégé

The present invention relates to a chronotherapeutic combination pharmaceutical formulation, which is designed to control the release of each ingredient of the combined drug in a predetermined rate based on the principle of the so-called chronotherapy, where drugs are administered to exhibit pharmacological activities at predetermined time intervals. The formulation of the present invention comprises a dihydropyridine, calcium channel blocker that affects cytochrome P450 enzyme, and a statin, lipid-lowering agent, as active ingredients. Further, it is prepared in such a manner that the respective release rate of the above ingredients can be controlled, thereby preventing antagonistic effects and side effects resulting from the interaction of the above ingredients, while maintaining the synergistic effect, and providing easy medication.

Classes IPC  ?

  • A61K 9/22 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue
  • A61K 9/20 - Pilules, pastilles ou comprimés
  • A61K 9/52 - Préparations en capsules, p. ex. de gélatine, de chocolat du type à libération prolongée ou discontinue

15.

FURAN-2-CARBOXYLIC ACID DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF

      
Numéro d'application KR2007003744
Numéro de publication 2008/016278
Statut Délivré - en vigueur
Date de dépôt 2007-08-03
Date de publication 2008-02-07
Propriétaire
  • KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (République de Corée)
  • HANALL PHARMACEUTICAL COMPANY LTD. (République de Corée)
Inventeur(s)
  • Cheon, Hyae-Gyeong
  • Kim, Kwang-Rok
  • Rhee, Sang-Dal
  • Jung, Won-Hoon
  • Kim, Hee-Youn
  • Lee, Jong-Cheol
  • Lee, Jung-Hwa
  • Lee, Kyung
  • Kim, Sung-Wuk
  • Jun, Sung-Soo

Abrégé

This invention relates to a furan-2-carboxylic acid derivative capable of activating AMP-activated protein kinase (AMPK), which is useful for the prevention and treatment of metabolic syndromes including diabete, obesity, hyperlipidemia, hypercholesterolemia, fatty liver and steatohepatitis factors.

Classes IPC  ?

  • C07D 307/68 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène

16.

MATRIX TABLETS PROVIDING AN EXTENDED RELEASE OF METFORMIN

      
Numéro d'application KR2006003739
Numéro de publication 2007/136151
Statut Délivré - en vigueur
Date de dépôt 2006-09-20
Date de publication 2007-11-29
Propriétaire HANALL Pharmaceutical Co., Ltd. (République de Corée)
Inventeur(s)
  • Jo, Young Gwan
  • Koo, Ja-Seong
  • Yim, Ju-Bin
  • Jun, Yoon-Sik

Abrégé

The present invention relates to a metformin extended release tablet, which is effective in treating noninsulin dependent diabetes mellitus, metformin is dispersed in a matrix in which hydrophilic polymers and hydrophobic materials are mixed at a specific proportion. The hydrophilie polymers -enable controlling of the pore size of the gel layer formed by water swelling, thereby enabling primary control of drug release rate. And, the hydrophobic materials block the pores of the gel layer, thereby enabling secondary control of drug release rate. Therefore, the metformin extended release tablet of the present invention has better dissolution properties than conventional extended tablets and, thus, enables extended drug release at constant rate even with less matrix. A constant blood level can be maintained with one administration a day and the tablet can be made smaller, which makes the administration easier and the production simplier.

Classes IPC  ?

  • A61K 31/155 - Amidines (), p. ex. guanidine (H2N-C(=NH)-NH2), isourée (HN=C(OH)NH2), isothiourée (HN=C(SH)-NH2)
  • A61K 9/26 - Particules distinctes dans une matrice support

17.

COMPOSITIONS FOR EXTERNAL APPLICATION, CONTAINING ADENOSYL COBALAMIN FOR IMPROVEMENT OF SKIN DISEASES

      
Numéro d'application KR2006004233
Numéro de publication 2007/066889
Statut Délivré - en vigueur
Date de dépôt 2006-10-18
Date de publication 2007-06-14
Propriétaire
  • KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (République de Corée)
  • HANALL PHARMACEUTICAL CO., LTD. (République de Corée)
Inventeur(s)
  • Shin, Byung Cheol
  • Seong, Hasoo
  • Lee, Aeri
  • Kong, Jae Yang
  • Cheon, Hyae Gyeong
  • Cho, Young Sik
  • Jun, Sung Soo
  • Jo, Young Gwan

Abrégé

The present invention relates to a composition for external application for improving a skin disease (e.g. psoriasis). Said composition contains adenosyl cobalamin (coenzyme B12), opt. in admixture with other cobalamins. Preferable said composition is present in the form of liposomal preparations, which are made of a phospholipid and cholesterol.

Classes IPC  ?

  • A61K 31/714 - Cobalamines, p. ex. cyanocobalamine, vitamine B12
  • A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
  • A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
  • A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques

18.

METFORMIN TABLET WITH SUSTAINED RELEASE AND METHOD FOR PREPARING THE SAME

      
Numéro d'application KR2006002360
Numéro de publication 2007/021072
Statut Délivré - en vigueur
Date de dépôt 2006-06-20
Date de publication 2007-02-22
Propriétaire HANALL Pharmaceutical Co., Ltd. (République de Corée)
Inventeur(s)
  • Jo, Young Gwan
  • Koo, Ja-Seong
  • Yim, Ju-Bin
  • Jun, Yoon-Sik

Abrégé

The present invention relates to a metformin tablet with sustained release and a method for preparing the same. Said method comprises the conversion of a pharmaceutical composition comprising metformin or a pharmaceutical acceptable salt thereof and a matrix into a slug, the granulation of said slug and the compaction of said granules into tablet cores. Optionally said cores may be coated by an appropriate film material.

Classes IPC  ?

  • A61K 31/155 - Amidines (), p. ex. guanidine (H2N-C(=NH)-NH2), isourée (HN=C(OH)NH2), isothiourée (HN=C(SH)-NH2)
  • A61K 9/26 - Particules distinctes dans une matrice support