The present application pertains to the technical field of animal husbandry and veterinary medicine, and discloses a compound amino acid solution for an animal, a preparation method therefor, and an application thereof. The compound amino acid solution is prepared by dissolving an excipient, nine kinds of amino acids, and a B vitamin in water, adding tryptophan for dissolution, and then performing pH value regulation, dilution to a specific volume, filtration, and other steps. The solution obtained is used to remediate nutritional deficiency of an animal, and is suitable for adding to water and feeding to the animal. By adding appropriate proportions of the amino acids and the vitamin, the vitamin promotes absorption of the amino acids and the amino acids promote the effectiveness of the vitamin, so as to provide the animal with an improved nutritional supplement, improve the metabolic level of the animal, accelerate blood circulation, promote recovery, and improve the productivity of the animal, solving the problem of animal nutritional deficiency.
A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61P 3/02 - Nutriments, p. ex. vitamines, minéraux
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 15/08 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les troubles gonadiques ou pour augmenter la fertilité, p. ex. inducteurs d'ovulation ou de spermatogénèse
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61P 15/14 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les troubles de la lactation, p. ex. galactorrhée
A feed additive for preventing diarrhea and improving immunity, and a preparation method therefor and an application thereof, relating to the technical field of animal husbandry and veterinary. The feed additive is prepared by uniformly mixing compound amino acids, probiotic powder, nicotinamide, chitosan, β-cyclodextrin and fulvic acid; the prepared additive is used for adding to animal feed and is suitable for feeding animals, especially for feeding poultry animals. By adding a reasonable ratio of the compound amino acids, the probiotic powder, immunopotentiators (the chitosan and the fulvic acid), and stabilizers for keeping beneficial bacteria stable (the niacinamide and the β-cyclodextrin), the immunity of animals can be effectively improved, diarrhea can be prevented/treated, production performance can be improved, and then use of antibiotics is reduced/replaced, thereby solving the problem of poor livestock resistance when drug feed additives are not used.
A23K 10/18 - Ajout de micro-organismes ou de leurs produits d’extraction, p. ex. de protéines provenant d’organismes unicellulaires, à des compositions de produits alimentaires de micro-organismes vivants
An anti-stress feed additive, a preparation method therefor and use thereof belong to the field of animal feed processing. The anti-stress feed additive is prepared by mixing and screening three basic amino acids, i.e. arginine, lysine and histidine, as raw materials. The three basic amino acids cooperate with each other to alleviate stress response synergistically, promote growth and development of animals, and improve feed utilization rate. The preparation method is simple, the production costs are low, and the prepared anti-stress feed additive has good palatability and stability, is suitable for consumption by chickens, and is used for relieving stress response.
The present application relates to the technical field of veterinary drugs, and specifically discloses a compound amino acid enteric-coated capsule for a dog. Based on 250 parts by weight, the raw materials for preparing the capsule comprise: 5-7 parts of lysine hydrochloride, 1-4 parts of methionine, 0.5-2 parts of tryptophan, 6-9 parts of leucine, 2-5 parts of isoleucine, 1-4 parts of valine, 4-7 parts of phenylalanine, 3-6 parts of histidine hydrochloride, 4-7 parts of arginine hydrochloride, 2-5 parts of threonine, 2-5 parts of a lubricant, and the remainder being a diluent. The compound amino acid enteric-coated capsule for a dog reduces adverse reactions caused by irritation to the stomach, reduces adverse effects of the drug on the appetite of dogs, supplements amino acids needed by the dogs' bodies, ensures the stability of active ingredients and good appearance of the drug, and prolongs the shelf life of the drug; moreover, the preparation method for the capsule is simple to operate, and is suitable for preparing the compound amino acid enteric-coated capsule for a dog.
The present invention relates to the field of pharmaceutical preparations. Specifically disclosed is a compound amino acid enteric-coated tablet for dogs. Raw materials for preparing active ingredients of the tablet comprise leucine, isoleucine, valine, glycine, proline, alanine, lysine hydrochloride, arginine hydrochloride, serine, threonine, histidine hydrochloride, methionine, phenylalanine, tryptophan, starch, sodium carboxymethyl starch, magnesium stearate, sodium carboxymethyl cellulose, a suspension A, and a suspension B. The steps for preparing the compound amino acid enteric-coated tablet for dogs comprise: preparing a tablet core, preparing an isolation layer, and preparing an enteric coating layer. The compound amino acid enteric-coated tablet for dogs reduces adverse reactions caused by stimulation to the stomach and supplements the requirements of dogs for amino acids, and the preparation method thereof is simple to operate. The preparation method is suitable for preparing the compound amino acid enteric-coated tablet for dogs, and the prepared compound amino acid enteric-coated tablet for dogs is suitable for dogs.
Disclosed are a compound amino acid oral solution for dogs and a preparation method therefor. The compound amino acid oral solution for dogs is mainly composed of compound amino acids, is added with jujube and fried rice sprout components, can supplement amino acids required by dogs, and has the functions of tonifying middle-Jiao and Qi, nourishing the blood and tranquilization, promoting digestion and regulating the middle warmer, and tonifying spleen and whetting the appetite. The compound amino acid oral solution for dogs is prepared by the steps of pulverizing, sieving, mixing, sterilizing, regulating a constant volume, stirring, filtering, etc. has simple operations, low costs, and good product stability, and is suitable for mass production. The compound amino acid oral solution for dogs is suitable for consumption in frail and diseased dogs.
2222; thus, the stability of the tryptophan and the tyrosine is effectively improved and the tryptophan and the tyrosine are prevented from being oxidized; the prepared injection is suitable for disease treatment of livestock and body recovery after diseases.
A compound amino acid injection for livestock. The effective components of the injection comprise 18 amino acids and γ-aminobutyric acid needed by animal bodies. By adjusting the dosage of leucine and using arginine hydrochloride, histidine hydrochloride, lysine hydrochloride and cysteine hydrochloride, the contents of various amino acids in the amino acid injection for livestock are increased; thus products are stabler, production cost is saved, a better curative effect is achieved, and the problem that existing compound amino acid injections for livestock are low in content is solved. A preparation method for the compound amino acid injection for livestock uses a step-by-step feeding manner, improving the stability and solubility of tryptophan, tyrosine and γ-aminobutyric acid and preventing oxidation thereof, and solving the problem of poor stability of existing compound amino acid injections for livestock. The compound amino acid injection for livestock is suitable for body repair in a disease treatment period and a post-disease recovery period of livestock animals.
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 31/4172 - Acides imidazole-alkanecarboxyliques, p. ex. histidine
A61K 31/401 - ProlineSes dérivés, p. ex. captopril
A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
A61P 3/02 - Nutriments, p. ex. vitamines, minéraux
9.
METHOD FOR PREPARING COMPOUND AMINO ACID INJECTION FOR LIVESTOCK
A method for preparing a compound amino acid injection for livestock, comprising the steps of adding an antioxidant under the protection of nitrogen; and adding 18 kinds of amino acids at one time at 60 to 70℃ under the protection of nitrogen, then adding γ-aminobutyric acid at 20 to 35 °C under the protection of nitrogen, and performing decoloration, thus solving the problem of high preparation costs of injections for livestock. Switching to nitrogen protection reduces the production costs. Further, adding 18 kinds of amino acids at one time under the condition of 60 to 70℃ reduces the operation process and labor intensity. Further, as the content of tyrosine and tryptophan in a solution is relatively high at 60 to 70 ℃, dissolving each amino acid at 60 to 70 ℃ can effectively increase the content of each amino acid in the injection. The prepared compound amino acid injection for livestock is suitable for body repair during the treatment of diseases and the recovery period after the diseases of livestock.
Disclosed is a method for determining the content of a compound amino acid injection. The method comprises the steps of solution preparation, separation and determination, and calculation etc. The content of each amino acid component in a tryptophan-containing compound amino acid injection is determined by means of one-time sample injection and separation. By means of the method for determining the content of a compound amino acid injection, the number of operation steps in a process for determining the amino acid content is reduced and the problem that the amino acid content is determined by means of repeated sample injection is solved. The method has the advantages of simplicity in operation, a visible process, rapidness, high precision, high accuracy, good repeatability, and low costs, and can be used for directly detecting a sample, so that the analysis time is greatly shortened and the method is suitable for rapid industrial analysis. The method is suitable for determining the content of each amino acid component in the compound amino acid injection.
Provided in the present invention are a gene tsh-Ser for preventing colibacillosis, a protein encoded thereby and the preparation method thereof. The method comprises: using 5'-atgaacagaatttatt-3' as an upstream primer zxl, 5'-gaatgaataacgaa-3' as a downstream primer zx2, and the plasmid DNA of a O78 serotype Escherichia coli as a template, and using a PCR amplification method to obtain the gene tsh-Ser for preventing colibacillosis, and then using the gene to obtain the protein encoded thereby.
The present invention discloses a method of preparing a broad spectrum vaccine for preventing avian colibacillosis, including recombining the tsh gene, which has an adhesive attraction effect, with E.coli BL21 (DE3); the resulting vaccine may preferentially bind to the corresponding receptors on avian body cells, resulting in there being no receptors to bind to the pathogenic E.coli, thus decreasing morbidity rates among avians.
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