The present invention relates to a cefoperazone magnesium compound, a preparation method therefor and an application thereof. A synergistic effect can be achieved by combining cefoperazone with magnesium; cefoperazone can inhibit the synthesis of pathogenic bacterium cell walls, has a strong effect on gram-negative bacteria, and significantly inhibits the synthesis of bacterial cell walls after being combined with magnesium elements; the use effect is remarkably enhanced. In the present invention, the cefoperazone magnesium compound is generated by reacting cefoperazone acid with magnesium ions, thereby improving the stability of a cefoperazone drug, and also providing a choice for patients who are clinically unsuitable for sodium salt. The cefoperazone magnesium compound in the present invention is a magnesium-containing antibiotic, has an antibacterial treatment effect and a magnesium supplement effect, has benefits to some inflammations, and has a synergistic effect. The preparation method for the cefoperazone magnesium is simple to operate, does not use organic solvents, does not generate toxic and harmful substances, has high product purity and is convenient for industrial production.
C07D 501/36 - Radicaux méthylène, substitués par des atomes de soufre
C07D 501/04 - Préparation à partir de composés contenant déjà les systèmes cycliques ou cycliques condensés, p. ex. par déshydrogénation du cycle, par introduction, élimination ou modification de substituants
A61K 33/06 - Aluminium, calcium ou magnésiumLeurs composés
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
Disclosed in the present invention are a cefuroxime magnesium compound, a composition, a preparation method therefor and the use thereof. The preparation method comprises: providing a cefuroxime-containing compound, and providing a magnesium compound; carrying out a chemical reaction on the cefuroxime-containing compound and the magnesium compound; and obtaining the product of the cefuroxime magnesium compound obtained by means of the chemical reaction. In this way, the present invention can provide technical support for realizing large-scale industrial production, and can improve the stability of a cefuroxime salt.
C07D 501/34 - Radicaux méthylène substitués par des atomes d'oxygèneLeurs lactones avec le groupe carboxyle-2 avec le radical amino-7 acylé par des acides carboxyliques contenant des hétérocycles
C07D 501/04 - Préparation à partir de composés contenant déjà les systèmes cycliques ou cycliques condensés, p. ex. par déshydrogénation du cycle, par introduction, élimination ou modification de substituants
A61K 31/546 - Composés contenant des systèmes cycliques thia-5 aza-1 bicyclo [4.2.0] octane, c.-à-d. composés contenant un système cyclique de formule , p. ex. céphalosporines, céfaclor, céphalexine contenant d'autres hétérocycles, p. ex. céphalotine
Disclosed in the present invention are a piperacillin magnesium compound, a composition, a preparation method and use. The preparation method comprises: providing a piperacillin-containing reactant, and providing a magnesium compound; performing a chemical reaction on the piperacillin-containing reactant and the magnesium compound; and harvesting a product of the piperacillin magnesium compound obtained by the chemical reaction. In this way, the present invention can provide technical support for achieving large-scale industrial production, and can improve the stability of piperacillin salts.
C07D 499/68 - Composés avec un radical amino acylé par des acides carboxyliques, lié en position 6 avec une chaîne carbonée, substituée par des hétéro-atomes ou par des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, liée au radical carboxamido substituée en position alpha du radical carboxamido par des atomes d'azote avec des cycles aromatiques en tant que substituants additionnels dans la chaîne carbonée
The present invention relates to a cefotaxime-magnesium compound, a preparation method therefor, and an application thereof. Cefotaxime is combined with magnesium so as to achieve a synergistic effect. Cefotaxime inhibits the cell wall synthesis of pathogenic bacteria and is highly effective against gram-negative bacteria, and combining cefotaxime with magnesium can significantly inhibit the cell wall synthesis of bacteria, further enhancing effectiveness. The present invention reacts cefotaxime acid with magnesium ions to generate a cefotaxime-magnesium compound, improves the stability of a cefotaxime drug, and provides a further option for treatment when sodium salts are clinically unsuitable for patients. The cefotaxime-magnesium compound of the present invention is an antibiotic containing magnesium, which has both an antibacterial treatment effect and a magnesium supplementation effect. The combination of magnesium and cefotaxime is beneficial against various types of inflammation and achieves a synergistic effect. The preparation method of the cefotaxime-magnesium compound is simple, does not use organic solvents, does not generate toxic or harmful substances, has high product purity, and is convenient for industrial production.
C07D 501/34 - Radicaux méthylène substitués par des atomes d'oxygèneLeurs lactones avec le groupe carboxyle-2 avec le radical amino-7 acylé par des acides carboxyliques contenant des hétérocycles
A61K 31/545 - Composés contenant des systèmes cycliques thia-5 aza-1 bicyclo [4.2.0] octane, c.-à-d. composés contenant un système cyclique de formule , p. ex. céphalosporines, céfaclor, céphalexine
The present invention relates to a baicalin magnesium and further relates to a preparation method and extraction method of the baicalin magnesium. The preparation method comprises the steps of preparing a suspension of a baicalin, preparing a suspension containing a magnesium ion, reacting, and drying. The extraction method comprises the steps of pre-processing with a macroporous adsorption resin, extracting, adsorbing and eluting, concentrating and drying, and purifying. The baicalin magnesium preparation restores the baicalin to an original form found in the Scutellaria baicalensis plant, and can be used as a substitute for the baicalin in pharmaceutical applications. Compared with the baicalin, the baicalin magnesium has greatly increased solubility, faster oral absorption rate and higher bioavailability. The baicalin magnesium can also be easily formulated as a water-soluble agent or powder agent for injection. Pharmacological experiments showed that the baicalin magnesium is more pharmacologically active than baicalin.
C07H 23/00 - Composés contenant du bore, du silicium ou un métal, p. ex. chélates ou vitamine B12
C07H 1/00 - Procédés de préparation des dérivés du sucre
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
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