05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Taurolidine containing pharmaceutical and veterinary preparations and substances for prevention or treatment of periodontitis or peritonitis; sanitary preparations for medical purposes; hemostatics for medical purposes; wound dressing material; wound sponges; medical adhesives for binding internal tissue; medical plasters; pharmaceutical products; material for filling teeth and materials for dental impressions; ceramics and cement for teeth and bones for orthopedic and surgical use; disinfectants; membrane and non-collagen tissues Surgical, medical, dental and veterinary apparatus and instruments in the nature of resorbable implants; orthopedic articles in the nature of resorbable implants; filling and implant materials of artificial origin for use in the dental, maxillofacial and orthopedic surgery, in particular for the regeneration of bone and soft tissue filling and implant materials derived from natural substances for dental, maxillofacial and orthopedic surgery, especially for the regeneration of bone and soft tissue; biocompatible collagen-material, in particular biocompatible collagen membranes, biocompatible collagen-matrixes or biocompatible collagen-sponge for use in dental, maxillofacial and orthopedic surgery, especially for the regeneration of bone and soft tissue, or for use as a hemostatic agent in the surgery and dressing; surgical collagen-implants, surgical collagen-adhesives; artificial teeth; artificial jaws; dentures; sets of artificial teeth; prosthesis; rings for dentition; surgical implants (artificial materials); dental drills; dental appliances; electrical, dental appliances and instruments; drills; mills; contra-angles; surgical engines; custom dentures; implant stability gauges; bone graft; biomaterials; dental equipment; prosthetic components, surgical instruments; materials for bone implants; natural bone implant materials Organization of seminars, workshops, training and continuing education courses in the fields of application of taurolidine, sanitary preparations, wound dressing material, wound sponges, medical adhesives, filling and implant materials, medical plasters, biocompatible collagen-material, in particular biocompatible collagen-membranes, biocompatible collagen-matrixes or biocompatible collagen-sponge, surgical collagen-implants, surgical collagen-adhesives, resorbable implants for use in dental, maxillofacial, orthopedic or visceral surgery
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Pharmaceutical and veterinary preparations and substances; Pharmaceutical products; sanitary products for medical use; hemostatic products; dressings, compresses; vulnerary sponges; tissue adhesives for medical purposes; filling and implant materials of natural origin for dental, maxillofacial and orthopedic surgery, especially for the regeneration of bone and soft tissue; adhesive plasters and dressings; Material for filling teeth and materials for dental impressions; Ceramics and cement for teeth and bones for orthopedic and surgical use; disinfectants; Membrane and non-collagen tissues. Surgical, medical, dental and veterinary apparatus and instruments; orthopedic articles; filling and implant materials of artificial origin for use in dental, maxillofacial and orthopedic surgery, in particular for the regeneration of bone and soft tissue; Materials of artificial origin for filling and implantation for use in dental, maxillofacial and orthopedic surgery; biocompatible collagen-material, in particular biocompatible collagen-membranes, biocompatible collagen-matrixes or biocompatible collagen-sponge for use in dental, maxillofacial and orthopedic surgery, especially for the regeneration of bone and soft tissue, or for use as a hemostatic agent in surgery, all the aforesaid goods included in this class; surgical collagen-implants included in this class; surgical collagen-sponges; artificial teeth; artificial jaws; Dentures; Sets of articifial teeth; implants [prosthesis]; rings for dentition; Surgical implants [artificial materials]; dental drills; dental appliances; electrical dental appliances and instruments; mills; contra-angle; surgical engines; custom dentures; Implant stability gauges; Bone graft; biomaterials; Dental equipment; prosthetic components, surgical instruments; materials for bone implants; natural bone implant materials. Organization of seminars, workshops, training and continuing education courses.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Materials for dentistry and dental repair, namely rubber for dental purposes, dental wax and molding wax for dentists, adhesives for dental and dentistry use, dental sealants and tooth filling materials for dental and dental technical purposes and tooth materials for repairing teeth Surgical, medical, dental, and veterinary instruments and apparatus, namely, surgical apparatus and instruments for medical, dental, or veterinary use; instruments for use in dental prosthetics; dental protection for medical purposes, namely, teeth protectors for dental purposes; lip and cheek retractors; lip and cheek holders being dental instruments
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Materials for dentistry, materials for dental repair, and dental prostheses. Surgical, medical, dental, and veterinary instruments and apparatus; instruments for use in dental prosthetics; dental protection for medical purposes; lip and cheek retractors; lip and cheek holders.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and veterinary preparations and substances for treating skin disorders, tooth loss, trauma or tumor resection, bone defect or loss, cartilage defects, chondral and osteochondral lesions, meniscal lesions, diabetes; hemostatic products, namely, dental hemostatic paste, medical hemostatic paste, hemostatic pencils; wound dressing material, namely, hemostatic gel matrix preparations for treating wounds, pharmaceutical preparations for treating wounds, liquid bandages for skin wounds; vulnerary sponges; tissue adhesives for medical purposes, namely, medical adhesives for binding internal tissue, medical adhesives tapes for binding wounds; filling and implant materials of natural origin for dental, maxillofacial and orthopedic surgery, especially for the regeneration of soft tissue, namely, skin grafts, processed human donor skin for the replacement of soft tissue; medical plasters and medical dressings; collagen for medical purposes, namely, biocompatible collagen-material, in particular biocompatible collagen-membranes, biocompatible collagen-matrixes or biocompatible collagen-sponge for use in dental, maxillofacial and orthopedic surgery, especially for the regeneration of soft tissue, or for use as a hemostatic agent in surgery Surgical, medical, dental and veterinary apparatus and instruments for use in orthopedic surgery, oral surgery, maxillofacial surgery; biocompatible collagen-material, in particular biocompatible collagen-membranes, biocompatible collagen-matrixes or biocompatible collagen-sponge, namely, collagen barrier membranes for oral, maxillofacial and orthopedic surgical procedures, especially for the regeneration of soft tissue, or for use as a hemostatic agent in surgery; surgical implants and surgical sponges comprised of synthetic collagen materials for use in soft tissue repair or the reconstruction of soft tissue deficiencies
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and veterinary preparations and substances for bone diseases, bone defects, bone deficiencies, peri-implant infections, periodontal disease, tooth loss, trauma or tumor resection, tumors; Materials for dental fillings; Materials for artificial teeth; Bone fillers consisting of living materials for dental, maxillofacial and orthopedic surgery, especially for the regeneration of bone Surgical, medical, dental and veterinary apparatus and instruments for use in orthopedic surgery and oral surgery; Bone void fillers consisting of artificial materials for surgical, medical and dental use; Implants comprising natural, non-living materials for surgical, medical and dental use; Artificial bone parts to be implanted in natural bones for surgical, medical and dental use; Prosthetic and filling materials, namely artificial materials for use in the replacement of bones and artificial bone growth media for maxillofacial and orthopedic surgery, especially for the regeneration of bone
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and veterinary preparations and substances for bone diseases, bone defects, bone deficiencies, peri-implant infections, periodontal disease, tooth loss, trauma or tumor resection, tumors; Materials for dental fillings; Materials for artificial teeth; Bone fillers consisting of living materials for dental, maxillofacial and orthopedic surgery, especially for the regeneration of bone Surgical, medical, dental and veterinary apparatus and instruments for use in orthopedic surgery and oral surgery; Bone void fillers consisting of artificial materials for surgical, medical and dental use; Implants comprising natural, non-living materials for surgical, medical and dental use; Artificial bone parts to be implanted in natural bones for surgical, medical and dental use; Prosthetic and filling materials, namely artificial materials for use in the replacement of bones and artificial bone growth media for maxillofacial and orthopedic surgery, especially for the regeneration of bone
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and veterinary preparations and substances for treating skin disorders, tooth loss, trauma or tumor resection, bone defect or loss, cartilage defects, chondral and osteochondral lesions, meniscal lesions, diabetes; hemostatic products, namely, dental hemostatic paste, medical hemostatic paste, hemostatic pencils; wound dressing material, namely, hemostatic gel matrix preparations for treating wounds, pharmaceutical preparations for treating wounds, liquid bandages for skin wounds; vulnerary sponges; tissue adhesives for medical purposes, namely, medical adhesives for binding internal tissue, medical adhesives tapes for binding wounds; filling and implant materials of natural origin for dental, maxillofacial and orthopedic surgery, especially for the regeneration of soft tissue, namely skin grafts, processed human donor skin for the replacement of soft tissue; medical plasters and medical dressings; collagen for medical purposes, namely, biocompatible collagen-material, in particular biocompatible collagen-membranes, biocompatible collagen-matrixes or biocompatible collagen-sponge for use in dental, maxillofacial and orthopedic surgery, especially for the regeneration of soft tissue, or for use as a hemostatic agent in surgery Surgical, medical, dental and veterinary apparatus and instruments for use in orthopedic surgery, oral surgery, maxillofacial surgery; biocompatible collagen-material, in particular biocompatible collagen-membranes, biocompatible collagen-matrixes or biocompatible collagen-sponge, namely, collagen barrier membranes for oral, maxillofacial and orthopedic surgical procedures, especially for the regeneration of soft tissue, or for use as a hemostatic agent in surgery; surgical implants and surgical sponges comprised of synthetic collagen materials for use in soft tissue repair or the reconstruction of soft tissue deficiencies
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and veterinary preparations and substances; filling and implant materials of natural origin for dental, maxillofacial and orthopedic surgery, especially for the regeneration of bone; natural implant materials and natural bone materials for surgical, medical and dental use. Surgical, medical, dental and veterinary apparatus and instruments; filling and implant materials of artificial origin for use in dental, maxillofacial and orthopedic surgery, in particular for the regeneration of bone.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and veterinary preparations and substances; hemostatic for medical purposes; wound dressing material; vulnerary sponges; tissue adhesives for medical purposes; filling and implant materials of natural origin for dental, maxillofacial and orthopedic surgery, especially for the regeneration of soft tissue; plasters and dressings; biocompatible collagen-material, in particular biocompatible collagen-membranes, biocompatible collagen-matrixes or biocompatible collagen-sponge for use in dental, maxillofacial and orthopedic surgery, especially for the regeneration of soft tissue, or for use as a hemostatic agent in surgery. Surgical, medical, dental and veterinary apparatus and instruments; surgical collagen-implants; surgical collagen-sponges.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and veterinary preparations and substances; filling and implant materials of natural origin for dental, maxillofacial and orthopedic surgery, especially for the regeneration of bone; natural implant materials and natural bone materials for surgical, medical and dental use. Surgical, medical, dental and veterinary apparatus and instruments; filling and implant materials of artificial origin for use in dental, maxillofacial and orthopedic surgery, in particular for the regeneration of bone.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and veterinary preparations and substances; Hemostatics for medical purposes; wound dressing material; vulnerary sponges; tissue adhesives for medical purposes; filling and implant materials of natural origin for dental, maxillofacial and orthopedic surgery, especially for the regeneration of soft tissue; plasters and dressings; biocompatible collagen-material, in particular biocompatible collagen-membranes, biocompatible collagen-matrixes or biocompatible collagen-sponge for use in dental, maxillofacial and orthopedic surgery, especially for the regeneration of soft tissue, or for use as a hemostatic agent in surgery; surgical collagen-implants; surgical collagen-sponges. Surgical, medical, dental and veterinary apparatus and instruments.
Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes of treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed. These compounds were found to have significantly longer half-life compared to taurolidine and taurultam.
C07D 419/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote, d'oxygène et de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
Compounds of formula (I) useful as antineoplastic and antimicrobial agents are disclosed Compositions and methods of using antineoplastic and antimicrobial compounds are disclosed.
Compounds of formula (I) useful as antineoplastic and antimicrobial agents are disclosed Compositions and methods of using antineoplastic and antimicrobial compounds are disclosed.
A61K 31/549 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame ayant plusieurs atomes d'azote dans le même cycle, p. ex. hydrochlorothiazide
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 31/54 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame
A61K 31/39 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des atomes d'oxygène dans le même cycle
A61K 31/541 - Thiazines non condensées contenant d'autres hétérocycles
A61K 31/549 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame ayant plusieurs atomes d'azote dans le même cycle, p. ex. hydrochlorothiazide
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 31/166 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome de carbone d'un groupe carboxamide lié directement au cycle aromatique, p. ex. procaïnamide, procarbazine, métoclopramide, labétalol
A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/502 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. cinnoline, phtalazine
A61K 31/5025 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 31/54 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 31/541 - Thiazines non condensées contenant d'autres hétérocycles
A61K 31/549 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame ayant plusieurs atomes d'azote dans le même cycle, p. ex. hydrochlorothiazide
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Cleansing solution for medical use, namely, catheter lock solution for installation in intra-corporal catheters between treatments for the prevention of catheter sepsis
19.
APPLICATOR OF A SPONGEOUS COLLAGEN MEMBRANE AND KIT COMPRISING SUCH APPLICATOR AND MEMBRANE
The invention provides an applicator of a spongeous collagen membrane and a kit comprising such applicator and such membrane. The applicator comprises an applicator body having a guide extending in a direction from the proximal end to the distal end of the applicator body and a sliding element slidably comprising a shaft portion movable along the guide. The sliding element is provided at its distal end with a contact portion for contacting the spongeous collagen membrane, and the contact portion of the sliding element comprises mechanical fixation means configured to releasably hold the spongeous collagen membrane without substantially generating forces acting in the distal direction on the spongeous collagen membrane over its area extension. The distal end of the applicator body comprises a release surface configured to apply a release force to the spongeous collagen membrane releasing it from the mechanical fixation means for application to the wound site. In this way, it is possible to prevent compression of the fragile membrane and maintain its properties during handling and placement onto the wound site.
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Surgical implants made of artificial materials for use in regenerative dentistry and oral surgery screws, in particular tenting screws, self-drilling screws and screw systems. Providing instructional and training services and educational seminars in the field of regenerative dentistry and oral surgery. Therapeutic treatment services in dental and maxillofacial surgery.
Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes of treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed. These compounds were found to have significantly longer half-life compared to taurolidine and taurultam.
C07D 419/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote, d'oxygène et de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Surgical implants made of artificial materials for use in regenerative dentistry and oral surgery screws, in particular tenting screws, self-drilling screws and screw systems Providing instructional and training services and educational seminars in the field of regenerative dentistry and oral surgery Therapeutic treatment services in dental and maxillofacial surgery
Compounds of formula (I) useful as antineoplastic and antimicrobial agents are disclosed Compositions and methods of using antineoplastic and antimicrobial compounds are disclosed.
A61K 31/54 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame
24.
OXATHIAZIN_DIOXIDE FOR TREATING, PREVENTING, INHIBITING OR REDUCING CYTOKINE RELEASE
A method of preventing, inhibiting or reducing cytokine release and the incidence of a cytokine release syndrome (CRS) or a cytokine storm in a subject with certain oxathiazin-like compounds and/or related compounds.
A61K 31/436 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'oxygène comme hétéro-atome du cycle, p. ex. rapamycine
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 31/4365 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique ayant le soufre comme hétéro-atome du cycle, p. ex. ticlopidine
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61K 31/549 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame ayant plusieurs atomes d'azote dans le même cycle, p. ex. hydrochlorothiazide
A61K 31/4166 - 1,3-Diazoles ayant des groupes oxo liés directement à l'hétérocycle, p. ex. phénytoïne
A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
A61K 31/17 - Amides, p. ex. acides hydroxamiques ayant le groupe N-C(O)-N ou N-C(S)-N, p. ex. urée, thiourée, carmustine
A61K 31/205 - Sels d'addition d'acides organiques avec des aminesSels d'ammonium quaternaire internes, p. ex. bétaïne, carnitine
A61K 31/54 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame
A61K 31/39 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des atomes d'oxygène dans le même cycle
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Collagen for use in dental medicine and in oral maxillofacial surgery, in the form of biocompatible gels and membranes for covering and regeneration of bone defects, used in laparoscopic surgery; surgical collagen-implants, used in laparoscopic surgery
Biocompatible membrane consisting of natural non-living material of porcine origin for covering and regeneration of cartilage defects in surgery in the nature of artificial cartilage; implants for dental and orthopedic surgery consisting of natural non-living material of porcine origin
Resorbable synthetic bone substitute material implants for use in human or veterinary medicine, in particular surgery and orthopedics, in particular biphasic bone substitute material based on calcium phosphate and hydroxylapatite; resorbable synthetic bone substitute material implants for use in human or veterinary medicine, in particular surgery and orthopedics
30.
APPLICATOR OF A SPONGEOUS COLLAGEN MEMBRANE AND KIT COMPRISING SUCH APPLICATOR AND MEMBRANE
The invention provides an applicator of a spongeous collagen membrane and a kit comprising such applicator and such membrane. The applicator comprises an applicator body having a guide extending in a direction from the proximal end to the distal end of the applicator body and a sliding element slidably comprising a shaft portion movable along the guide. The sliding element is provided at its distal end with a contact portion for contacting the spongeous collagen membrane, and the contact portion of the sliding element comprises mechanical fixation means configured to releasably hold the spongeous collagen membrane without substantially generating forces acting in the distal direction on the spongeous collagen membrane over its area extension. The distal end of the applicator body comprises a release surface configured to apply a release force to the spongeous collagen membrane releasing it from the mechanical fixation means for application to the wound site. In this way, it is possible to prevent compression of the fragile membrane and maintain its properties during handling and placement onto the wound site.
A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.
A61L 27/44 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Instructional and teaching material, namely, printed manuals and handbooks for therapeutic treatments. Treatment of biopharmaceutical materials. Educational and training services, namely, practical trainings, live workshops and online lectures in the field of therapeutic treatment.
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Online learning modules recorded and downloadable on computer media. Providing online trainings and educational modules for Healthcare Professionals. Software as a Service [SaaS] for user-defined information and programs in the field of regenerative dentistry.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Instructional and teaching material, namely, printed manuals and handbooks in the field of therapeutic treatments Educational and training services, namely, practical trainings, namely, teaching, practical training seminars, featuring hands-on exercises with flyers and leaflets with instructions, live and online workshops and online lectures presented via video-on-demand in the field of therapeutic treatment
09 - Appareils et instruments scientifiques et électriques
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Downloadable educational simulation software featuring instruction in the field of regenerative dentistry, organized into learning modules; Recorded educational simulation software featuring instruction in the field of regenerative dentistry, organized into learning modules Blended educational services for healthcare professionals, namely, providing online and onsite classes, seminars, trainings, workshops, arranging and conducting of colloquiums and seminars, teaching, tutoring, coaching, arranging and conducting of in-person educational forums, all in the field of dental training, all the foregoing organized into learning modules and featuring training activities Software as a service (SAAS) services featuring software for teaching healthcare professionals using user-defined information in the field of regenerative dentistry
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Biological bone tissue intended for subsequent implantation, namely, natural bone substitute for surgical use consisting of a mixture of a resorbable bovine bone derived deproteinized mineral implant material and a human bone tissue derived particulate allograft implant material, for use in human surgery, namely, in dental, oral and maxillofacial surgery Bone substitute for surgical use, namely, biochemical preparations consisting of a resorbable bovine bone derived deproteinized mineral implant material and a resorbable human bone derived particulate allograft implant material, namely, an artificial resorbable human bone demineralized particulate allograft implant material, for use in human surgery, namely, in dental, oral and maxillofacial surgery
Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes of treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed. These compounds were found to have significantly longer half-life compared to taurolidine and taurultam.
C07D 419/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote, d'oxygène et de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Surgical implants (made of artificial materials) for use in
regenerative dentistry or in oral surgery; bone screws,
especially umbrella screws. Instruction services, education, training, seminars in
regenerative dentistry and oral surgery. Therapeutic treatment services in dental and maxillofacial
surgery.
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Surgical implants made of artificial materials for use in regenerative dentistry and oral surgery screws, in particular umbrella screws Providing instructional and training services and educational seminars in the field of regenerative dentistry and oral surgery Therapeutic treatment services in dental and maxillofacial surgery
An injectable aqueous implant formulation, and processes for making and using the formulation, wherein the injectable aqueous implant formulation has been sterilized by gamma-ray or X-ray-irradiation and can be extruded through a tapering system and an 18 gauge (0.838 mm inner diameter) 25.4 mm long cannula with a force not exceeding 60 N, which comprises 25-45 w/w % of a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 μm as determined by sieving and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve, whereby the w/w ratio of nanocrystalline hydroxyapatite to collagen is from 1.8 to 4.5, which contains at least 0.05% (w/w) ascorbic acid.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 33/06 - Aluminium, calcium ou magnésiumLeurs composés
A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
A61K 31/375 - Acide ascorbique, c.-à-d. vitamine CSes sels
A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
The invention relates to: An injectable aqueous implant formulation for use in oral tissue regeneration which has been sterilized by gamma-ray or X-ray- irradiation and can be extruded through a tapering system and an 18 gauge (0.838 mm inner diameter) 25.4 mm long cannula with a force not exceeding 60 N, which comprises 25-45 w/w % of a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 pm as determined by sieving and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve, whereby the w/w ratio of nanocrystalline hydroxyapatite to collagen is from 1.8 to 4.5, which contains at least 0.05 % (w/w) ascorbic acid, and a process for preparing the above injectable aqueous implant formulation
The invention concerns: - A collagen matrix, in particular for use as a putty, a strip or a plug, comprising particles of a biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and at least one closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a non-homogeneous external surface comprising individual clusters of flat crystal platelets consisting of epitactically grown HAP nanocrystals and coarse areas between the individual clusters, whereby the percentage of the coarse areas between the individual clusters as measured by SEM is at least 20% of the total surface, - a process for preparing that collagen matrix, and - a granulate blend comprising particles of such a biphasic bone material.
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
44.
Collagen matrix or granulate blend of bone substitute material
Collagen matrix granulate blend, and process for making and using a collagen matrix or granulate blend including collagen and particles of a biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and having its total external surface covered by at least one closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP is transformed from the CAP on the external surface of the sintered CAP core has a non-homogeneous external surface comprising individual clusters of flat crystal platelets consisting of epitactically grown HAP nanocrystals and coarse areas between the individual clusters, whereby the percentage of the coarse areas between the individual clusters as measured by SEM is at least 20% of the total surface.
A61L 27/32 - Matériaux contenant du phosphore, p. ex. apatite
A61L 27/40 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
45.
Collagen matrix or granulate blend of bone substitute material
A collagen matrix, granulate blend, and process for making and using a collagen matrix or granulate blend including collagen and particles or granules of a biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material comprising a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a homogeneous coarse external surface comprising flat crystal platelets.
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
46.
COLLAGEN MATRIX OR GRANULATE BLEND OF BONE SUBSTITUTE MATERIAL
The invention concerns: - A collagen matrix, in particular for use as a putty, a strip or a plug, comprising particles of a biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material comprising a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a homogeneous coarse external surface comprising flat crystal platelets, - a process for preparing that collagen matrix, and - a granulate blend comprising particles of such a biphasic bone material.
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A61L 31/12 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61K 31/553 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant au moins un azote et au moins un oxygène comme hétéro-atomes d'un cycle, p. ex. loxapine, staurosporine
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A method of preventing, inhibiting or reducing cytokine release and the incidence of a cytokine release syndrome (CRS) or a cytokine storm in a subject with certain oxathiazin-like compounds and/or related compounds.
A61K 31/553 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant au moins un azote et au moins un oxygène comme hétéro-atomes d'un cycle, p. ex. loxapine, staurosporine
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A method of preventing, inhibiting or reducing cytokine release and the incidence of a cytokine release syndrome (CRS) or a cytokine storm in a subject with certain N-methylol transfer agents and/or related compounds.
A61K 31/549 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame ayant plusieurs atomes d'azote dans le même cycle, p. ex. hydrochlorothiazide
A61K 31/17 - Amides, p. ex. acides hydroxamiques ayant le groupe N-C(O)-N ou N-C(S)-N, p. ex. urée, thiourée, carmustine
(1) Bone substitute for surgical use, namely, biochemical preparations consisting of a resorbable bovine bone derived deproteinized mineral implant material and a resorbable human bone derived allograft implant material, in particular, an artificial resorbable human bone demineralized implant material, for use in human surgery, in particular in dental and maxillofacial surgery
52.
Dried implant composition and injectable aqueous implant formulation
A dried implant composition for preparing an injectable aqueous implant formulation that is extrudable through a tapering system and a gauge 18 cannula, including a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 μm and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve; an injectable aqueous implant formulation, wherein the injectable aqueous implant formulation is obtainable by hydration and homogeneous mixing; a process for preparing the injectable aqueous implant formulation; and a kit for preparing the injectable aqueous implant formulation.
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
53.
Method for treating subjects suffering from chronic ulcers
A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.
A61L 27/44 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Biocompatible collagen membrane for medical purposes made of
natural, non-living material, of animal origin, in
particular for covering menisci. Artificial biocompatible collagen implant made from
processed natural material, of animal origin, in particular
for covering menisci.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Collagen preparations for medical purposes, namely,
biocompatible collagen membrane made of natural, non-living
material, of animal origin, in particular for covering
cartilage defects, especially in the meniscus. Medical implants made of artificial materials, namely,
artificial biocompatible collagen implants made of processed
natural material, of animal origin, in particular for
covering cartilage defects, especially in the meniscus. Organization of seminars, workshops, training and ongoing
training in orthopedic surgery.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Biocompatible collagen membrane for medical purposes made of
natural, non-living material, of animal origin, in
particular for covering tendons, ligaments and joints. Artificial biocompatible collagen implant made from
processed natural material, of animal origin, in particular
for covering tendons, ligaments and joints.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
(1) Collagen preparations for medical purposes, namely, biocompatible collagen membrane made of natural, non-living material, of animal origin, in particular for covering cartilage defects, especially in the meniscus
(2) Medical implants made of artificial material, namely, artificial biocompatible collagen implants made of processed natural material, of animal origin, in particular for covering cartilage defects, especially in the meniscus (1) Organization of seminars, workshops, training and ongoing education in orthopedic surgery
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Collagen preparations for medical purposes, namely, biocompatible collagen membrane made of natural, non-living material, of animal origin, in particular for covering cartilage defects, especially in the meniscus Medical implants made of artificial material, namely, artificial biocompatible collagen implants made of processed natural material, of animal origin, in particular for covering cartilage defects, especially in the meniscus Organization of seminars, workshops, training and ongoing continuing education courses in orthopedic surgery
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Surgical implants, namely, a biocompatible, naturally resorbable porcine collagen membrane made of natural, non-living material inserted over damaged tendons, ligaments and joints for use in guided tissue regeneration
(2) Artificial biocompatible collagen implants for surgical use made from processed natural material, of animal origin, inserted over damaged tendons, ligaments and joints for use in guided tissue regeneration
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Collagen preparations for medical purposes, namely, biocompatible collagen membrane made of natural, non-living material, of animal origin, in particular for covering cartilage defects, especially in the meniscus. Medical implants made of artificial materials, namely, artificial biocompatible collagen implants made of processed natural material, of animal origin, in particular for covering cartilage defects, especially in the meniscus. Organization of seminars, workshops, training and ongoing education in orthopedic surgery.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Biocompatible collagen membrane for medical purposes made of natural, non-living material, of animal origin, in particular for covering tendons, ligaments and joints Artificial biocompatible collagen implant made from processed natural material, of animal origin, in particular for covering tendons, ligaments and joints
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Biocompatible collagen membrane for medical purposes made of natural, non-living material, of animal origin, in particular for covering menisci Artificial biocompatible collagen implant made from processed natural material, of animal origin, in particular for covering menisci
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Biocompatible collagen membrane for medical purposes made of natural, non-living material, of animal origin, in particular for covering menisci. Artificial biocompatible collagen implant made from processed natural material, of animal origin, in particular for covering menisci.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Biocompatible collagen membrane for medical purposes made of natural, non-living material, of animal origin, in particular for covering menisci. Artificial biocompatible collagen implant made from processed natural material, of animal origin, in particular for covering tendons, ligaments and joints.
A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a homogeneous coarse external surface comprising flat crystal platelets, which shows an enhanced osteogenic response, a method of promoting bone formation, bone regeneration and/or bone repair by implanting the biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material, and a process of preparation thereof.
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
A61L 27/42 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice inorganique
B33Y 80/00 - Produits obtenus par fabrication additive
Methods for producing compounds useful in reactions to produce oxathiazin-like compounds are disclosed including a process of adding sodium 2-bromoethanesulfonate to a solution of benzyl alcohol and sodium benzyloxide to for mixture, boiling the mixture to reflux four times, concentrating under vacuum until dry, boiling with ethyl alcohol, filtering the ethyl alcohol, and concentrating to dryness to obtain solid sodium 2-benzyletherethanesulfonate.
C07D 419/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote, d'oxygène et de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Biochemical preparations consisting of a resorbable natural
bone derived implant material and a resorbable synthetic
bone substitute material, in particular trichlorophosphate
TCP or biphasic bone substitute based on calcium
phosphate/hydroxyapatite for use in human or veterinary
surgery, in particular in dental surgery.
71.
Dried implant composition and injectable aqueous implant formulation
A dried implant composition for preparing an injectable aqueous implant formulation that is extrudable through a tapering system and a gauge 18 cannula, including a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 μm and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve; an injectable aqueous implant formulation for use in a method of oral tissue regeneration, wherein the injectable aqueous implant formulation is obtainable by hydration and homogeneous mixing; a process for preparing the injectable aqueous implant formulation; and a kit for preparing the injectable aqueous implant formulation for use in oral tissue regeneration.
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Injectable medical preparations consisting of a mixture of
biocompatible collagen and particles of a resorbable natural
bone-derived implant material for use in human or veterinary
surgery, in particular in dental surgery.
A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and at least one closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a non-homogeneous external surface comprising individual clusters of flat crystal platelets consisting of epitactically grown HAP nanocrystals and coarse areas between the individual clusters, whereby the percentage of the coarse areas between the individual clusters as measured by SEM is at least 20% of the total surface, which material shows an increased capacity to induce bone formation, and a process of preparation thereof.
The invention relates to: - A dried implant composition consisting essentially of a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 µm and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve, whereby the w/w ratio of hydroxyapatite to collagen is from 1.8 to 4.5; - the use of that dried implant composition for preparing an injectable aqueous implant formulation for use in oral tissue regeneration that is extrudable through a tapering system and a gauge 18 (0.838 mm inner diameter) 25.4 mm long cannula; - an injectable aqueous implant formulation for use in oral tissue regeneration, wherein the injectable aqueous implant formulation is obtainable by rehydration and homogeneous mixing of 25-45 w/w % of the above dried implant composition with sterile water or a sterile isotonic saline solution, which can be extruded through a tapering system and an 8 gauge (0.838 mm inner diameter) 25.4 mm long cannula with a force not exceeding 60 N; - a process for preparing the above injectable aqueous implant formulation comprising rehydrating and homogeneously mixing 25-45 w/w % of a 20 dried implant composition as defined above in sterile water or a sterile isotonic saline solution; - a kit for preparing the above injectable aqueous implant formulation for use in oral tissue regeneration, which comprises: - a syringe equipped with a mixing device which contains a dried implant 2 composition as defined above, a tapering system and a gauge 18 (0.838 mm inner diameter) 25.4 mm long cannula; - a container filled with an appropriate amount of sterile water or a sterile isotonic solution.
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
75.
DRIED IMPLANT COMPOSITION AND INJECTABLE AQUEOUS IMPLANT FORMULATION
The invention relates to: An injectable aqueous implant formulation for use in oral tissue regeneration which can be extruded through a tapering system and an (18) gauge (0.838 mm inner diameter) (25.4) mm long cannula with a force not exceeding (60) N, which comprises (25-45) w/w % of a dried implant composition consisting essentially of a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of (50) to (200) µm and fragments of naturally crosslinked fibrouscollagen material that pass through a (0.5) mm sieve, whereby the w/w ratio of nanocrystalline hydroxyapatite to collagen is from (1.8) to (4.5), rehydrated and homogeneously mixed with sterile water or a sterile isotonic saline solution; -aprocess for preparing the aboveinjectable aqueous implant formulation comprising rehydrating and homogeneously mixing (25-45) w/w % of a dried implant composition as defined abovein sterile water or a sterile isotonic saline solution; - a kit for preparing the above injectable aqueous implant formulation for use in oral tissue regeneration, which comprises: - a syringe equipped with a mixing device which contains a dried implant composition as defined above, a tapering system and a gauge (18) (0.838 mm inner diameter) (25.4) mm long cannula - a container filled with an appropriate amount of sterile water or a sterile isotonic solution.
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
The invention relates to: -a biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material comprising a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a homogeneous coarse external surface comprising flat crystal platelets, which shows an enhanced osteogenic response, and -a process of preparation thereof comprising the steps of a)preparing a sintered CAP core material, b)immersing the sintered CAP core material in a buffer solution containing to 90 % of a short-chain aliphatic alcohol at a temperature between 10°C and 0°C to start the transformation process of CAP to HAP whereby a closed epitactically grown layer of nanocrystalline hydroxyapatite will be formed on the sintered CAP core material surface,whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP formed on the sintered CAP core material surface has a homogeneous coarse external surface comprising flat crystal platelets, c)stopping the transformation by separating solid material from the aqueous solution at a time when a closed coating of at least one nanocrystalline layer of HAP is present but before the transformation process is finished completely, and d) optionally sterilizing the separated material coming from step c).
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Injectable medical preparations consisting of a mixture of biocompatible collagen and particles of a resorbable natural bone-derived implant material for use in human or veterinary surgery, in particular in dental surgery
Bone substitutes for surgical use, namely, biochemical preparations consisting of a resorbable natural bone derived implant material and a resorbable synthetic bone substitute material, in particular trichlorophosphate TCP or biphasic bone substitute based on calcium phosphate/hydroxyapatite for use in human or veterinary surgery, in particular in dental surgery
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Injectable medical preparations consisting of a mixture of biocompatible collagen and particles of a resorbable natural bone-derived implant material for use in human or veterinary surgery, in particular in dental surgery
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Injectable medical preparations consisting of a mixture of biocompatible collagen and particles of a resorbable natural bone-derived implant material for use in human or veterinary surgery, in particular in dental surgery.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Biochemical preparations consisting of a resorbable natural bone derived implant material and a resorbable synthetic bone substitute material, in particular trichlorophosphate TCP or biphasic bone substitute based on calcium phosphate/hydroxyapatite for use in human or veterinary surgery, in particular in dental surgery.
A method of treating a patient suffering from TNBC by a multidisciplinary method involving treating the patient with a plurality of the following treatments: i) one or more checkpoint inhibitors; ii) hyperthermia treatment; iii) low dose chemotherapy; iv) Interleukin-2 (IL-2); and v) a compound selected from the group consisting of taurolidine, taurultam, oxathiazin-like compounds, and combinations thereof.
A61K 31/54 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 31/549 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame ayant plusieurs atomes d'azote dans le même cycle, p. ex. hydrochlorothiazide
A61K 31/541 - Thiazines non condensées contenant d'autres hétérocycles
Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes for efficient and safe manufacture of compounds useful for making oxathiazin-like compounds useful for treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed.
C07D 303/22 - Éthers avec des composés hydroxyles ne contenant pas de cycles oxirane avec des composés monohydroxylés
C07D 303/32 - Composés contenant des cycles oxirane avec des radicaux hydrocarbonés, substitués par des atomes d'oxygène liés par des liaisons simples ou doubles par des radicaux aldéhydiques ou cétoniques
C07C 303/22 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides d'acides sulfoniques ou de leurs halogénures à partir d'acides sulfoniques par des réactions n'impliquant pas la formation de groupes sulfo ou halogénosulfonyle
C07C 303/32 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides de sels d'acides sulfoniques
Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes of treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed. These compounds were found to have significantly longer half-life compared to taurolidine and taurultam.
C07D 419/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote, d'oxygène et de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
85.
Resorbable crosslinked form stable membrane for use outside the oral cavity
The invention relates to resorbable crosslinked form stable membrane which comprises a composite layer of collagen material and inorganic ceramic particles containing 1.5 to 3.5 weight parts of inorganic ceramic for 1 weight part of collagen material, sandwiched between two layers of elastic pretensed collagen material (collagen material that has been stretched such as to be in the linear/elastic region of the stress-strain curve), the collagen material comprising 50-100% (w/w) collagen and 0-50% (w/w) elastin, and has shape and dimensions suitable for use in human tissue regeneration outside the oral cavity in rhinoplasty, postlateral spinal fusion or orbital reconstruction.
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A61L 27/44 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
A61F 2/18 - Parties internes de l'oreille ou du nez, p. ex. tympans
The invention relates to resorbable crosslinked form stable membrane which comprises a composite layer of collagen material and inorganic ceramic particles containing 1.5 to 3.5 weight parts of inorganic ceramic for 1 weight part of collagen material, sandwiched between two layers of elastic pretensed collagen material (collagen material that has been stretched such as to be in the linear/elastic region of the stress-strain curve), the collagen material comprising 50-100 % (w/w) collagen and 0-50 % (w/w) elastin, and has shape and dimensions suitable for use in human tissue regeneration outside the oral cavity in rhinoplasty, postlateral spinal fusion or orbital reconstruction.
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A resorbable crosslinked form stable membrane containing a composite layer of collagen material and inorganic ceramic particles containing 1.5 to 3.5 weight parts of inorganic ceramic for 1 weight part of collagen material, sandwiched between two layers of elastic pretensed collagen material, wherein the elastic pretensed collagen material is collagen material that has been stretched such as to be in the linear/elastic region of the stress-strain curve, the collagen material comprising 50-100% (w/w) collagen and 0-50% (w/w) elastin.
A61C 8/02 - Moyens pour la transfixation des dents naturelles
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes for efficient and safe manufacture of compounds useful for making oxathiazin-like compounds useful for treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed.
C07C 303/22 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides d'acides sulfoniques ou de leurs halogénures à partir d'acides sulfoniques par des réactions n'impliquant pas la formation de groupes sulfo ou halogénosulfonyle
C07C 303/32 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides de sels d'acides sulfoniques
C07C 303/38 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides d'amides d'acides sulfoniques par réaction d'ammoniac ou d'amines avec des acides sulfoniques ou avec leurs esters, leurs anhydrides ou leurs halogénures
C07C 303/40 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides d'amides d'acides sulfoniques par des réactions n'impliquant pas la formation de groupes sulfonamide
A method of treating a patient suffering from TNBC by a multidisciplinary method involving treating the patient with a plurality of the following treatments: i) one or more checkpoint inhibitors; ii) hyperthermia treatment; iii) low dose chemotherapy; iv) lnterleukin-2 (IL-2); and v) a compound selected from the group consisting of taurolidine, taurultam, oxathiazin-like compounds, and combinations thereof.
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
A61K 31/54 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame
A61K 31/541 - Thiazines non condensées contenant d'autres hétérocycles
New oxathiazin-like compounds and their derivatives are useful as antineoplastic and antimicrobial agents. Compositions and methods of using oxathiazin-like compounds and their derivatives are disclosed.
C07D 419/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote, d'oxygène et de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
C07D 327/10 - Composés hétérocycliques contenant des cycles comportant des atomes de soufre et d'oxygène comme uniques hétéro-atomes du cycle deux atomes d'oxygène et un atome de soufre, p. ex. sulfates cycliques
A61K 31/39 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des atomes d'oxygène dans le même cycle
A61K 31/54 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 31/549 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame ayant plusieurs atomes d'azote dans le même cycle, p. ex. hydrochlorothiazide
A61K 31/541 - Thiazines non condensées contenant d'autres hétérocycles
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The invention relates to: -A resorbable crosslinked form stable membrane which comprises a composite layer of collagen material and inorganic ceramic particles containing 1.5 to 3.5 weight parts of inorganic ceramic for 1 weight part of collagen material, sandwiched between two layers of elastic pretensed collagen material, the collagen material comprising 50-100 % (w/w) collagen and 0-50 % (w/w) elastin, -the above crosslinked resorbable crosslinked form stable membrane for use as an implant to support bone formation, bone regeneration, bone repair and/or bone replacement at a non-containing dental bony defect site in a human or animal, -a process for preparing the above crosslinked resorbable crosslinked form stable membrane comprising the steps of: (a) Preparing a composite layer of inorganic ceramic particles and collagen material, optionally crosslinking that composite layer, (b) Assembling and glueing the composite layer of collagen material and inorganic ceramic particles between two layers of collagen material submitted to tensioning leading to a stretching of the collagen material in the linear region of the stress-strain curve, thereby giving a composite layer of collagen material and inorganic ceramic particles sandwiched between two layers of elastic pretensed collagen material, and (c) Crosslinking that composite layer of collagen material and inorganic ceramic particles sandwiched between two layers of elastic pretensed collagen material, followed by a hydrophilic making treatment.
A61L 27/46 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire avec des charges inorganiques contenant du phosphore
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps