Abrégé

The present invention provides a natural product-derived substance having an anti-inflammatory effect. It was found that a composition extracted from watermelon staminate flowers has the ability to suppress production of nitric oxide by macrophages, leading to the conception of an anti-inflammatory composition extracted from watermelon staminate flowers according to the present invention. An anti-inflammatory composition extracted from watermelon staminate flowers according to the present invention was confirmed to reduce the concentration of nitric oxide in cells in a concentration-dependent manner, and is expected to be suitably used in therapeutic agents against sepsis and autoimmune diseases. In addition, the anti-inflammatory composition is considered to have few side effects because of being derived from watermelon. Further, the anti-inflammatory composition can be expected to serve as an alleviation agent for some autoimmune diseases since the anti-inflammatory composition is considered to suppress iNOS induction and TNF-α production by inhibiting the activation of NF-κB.

Classes IPC  ?

• A61K 36/42 - Cucurbitaceae (famille du concombre)
• A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 31/04 - Agents antibactériens
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• A61K 133/00 - Parties de plantes contenant des fleurs ou obtenues à partir de fleurs

Abrégé

It is known that phytol contained in watermelon sprouts has a cancer cell growth inhibiting effect. However, there is a problem that the amount to be ingested for exerting a cancer cell growth inhibiting effect is large.　A cancer cell growth inhibiting composition containing at least one component selected from a compound having a structure represented by formula (123) and pharmaceutically acceptable salts thereof as an active ingredient has a higher cancer cell growth inhibiting effect and a lower normal cell growth inhibiting effect than those of phytol and therefore can be used as an anticancer agent having excellent selectivity to cancer cells. R represents a C1-C3 alkyl group.

Classes IPC  ?

• C07C 381/12 - Composés sulfonium
• A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
• A61K 31/10 - SulfuresSulfoxydesSulfones
• A61P 35/00 - Agents anticancéreux
• C07C 317/08 - SulfonesSulfoxydes ayant des groupes sulfone ou sulfoxyde liés à des atomes de carbone acycliques d'un squelette carboné acyclique non saturé

Abrégé

Phytol contained in watermelon sprouts is known to have an antiproliferative effect on cancer cell. However, there has been a problem in that a high dose is required to exert the antiproliferative effect on cancer cell. Phytol contained in watermelon sprouts is known to have an antiproliferative effect on cancer cell. However, there has been a problem in that a high dose is required to exert the antiproliferative effect on cancer cell. A cancer cell growth-inhibiting composition including a substance having structures represented by formulas (1) to (6) has a higher antiproliferative effect on cancer cell than phytol by order of one or more magnitudes. Further, it is expected that these substances do not affect normal cells similarly to phytol. Thus, they are expected to provide an anticancer drug with less side effects. Phytol contained in watermelon sprouts is known to have an antiproliferative effect on cancer cell. However, there has been a problem in that a high dose is required to exert the antiproliferative effect on cancer cell. A cancer cell growth-inhibiting composition including a substance having structures represented by formulas (1) to (6) has a higher antiproliferative effect on cancer cell than phytol by order of one or more magnitudes. Further, it is expected that these substances do not affect normal cells similarly to phytol. Thus, they are expected to provide an anticancer drug with less side effects.

Classes IPC  ?

• A61K 31/131 - Amines, p. ex. amantadine acycliques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/14 - Composés d'ammonium quaternaire, p. ex. édrophonium, choline
• A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention provides an anti-inflammatory agent containing a compound having an anti-inflammatory effect and contained in juvenile citrullus.　The anti-inflammatory agent comprises a compound represented by formula (1) or formula (2) as an active ingredient.

Classes IPC  ?

• A61K 31/7034 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine
• A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
• A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
• A61K 8/60 - SucresLeurs dérivés
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61Q 13/00 - Formulations ou additifs pour les préparations de parfums
• A61Q 19/00 - Préparations pour les soins de la peau

Abrégé

Provided is a novel compound that is contained in a young watermelon fruit and has an antioxidative effect. Provided is a novel compound that is contained in a young watermelon fruit and has an antioxidative effect. The novel compound that is contained in a young watermelon fruit and is represented by the formula (1) or formula (2) has an antioxidative effect and further has a skin anti-aging effect. Since these compounds are extracts from plants that are naturally edible, they are very safe for human bodies. Therefore, an antioxidative pharmaceutical composition, an antioxidative processed food composition, and an anti-skin aging composition, which contain these compounds as active ingredients, have high utility value as highly safe compositions. Provided is a novel compound that is contained in a young watermelon fruit and has an antioxidative effect. The novel compound that is contained in a young watermelon fruit and is represented by the formula (1) or formula (2) has an antioxidative effect and further has a skin anti-aging effect. Since these compounds are extracts from plants that are naturally edible, they are very safe for human bodies. Therefore, an antioxidative pharmaceutical composition, an antioxidative processed food composition, and an anti-skin aging composition, which contain these compounds as active ingredients, have high utility value as highly safe compositions.

Classes IPC  ?

• C07H 15/203 - Carbocycles monocycliques autres que des cycles cyclohexaneSystèmes carbocycliques bicycliques
• A61Q 19/08 - Préparations contre le vieillissement
• A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
• A61K 8/60 - SucresLeurs dérivés

Abrégé

The phytol contained in watermelon sprouts is known to have a cancer cell growth inhibiting effect. The problem, however, is the amount ingested to inhibit cancer cell growth is large.　A cancer cell growth inhibiting composition having a substance having a structure represented by formulas (1) through (6) as the main component has a cancer cell growth inhibiting effect one or more orders of magnitude greater than that of phytol. Like phytol, these substances are expected to have no effect on normal cells. Provision of an anticancer agent with few side effects can therefore be expected.

Classes IPC  ?

• A61K 31/131 - Amines, p. ex. amantadine acycliques
• A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
• A61K 31/14 - Composés d'ammonium quaternaire, p. ex. édrophonium, choline
• A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
• A61P 35/00 - Agents anticancéreux
• A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie

Abrégé

Phytol contained in watermelon sprouts is known to have a cancer cell growth inhibiting effect. However, there is a problem that an amount of phytol to be taken for exhibiting cancer cell growth inhibition is large. A cancer cell growth inhibiting composition comprising at least one of compounds having a structure represented by Formula (1), Formula (2), Formula (6), Formula (7) or Formula (8), or a pharmaceutically acceptable salt thereof as main components has a higher cancer cell growth inhibiting effect than phytol.

Classes IPC  ?

• C07C 233/09 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec des atomes de carbone de groupes carboxamide liés à des atomes de carbone d'un squelette carboné acyclique non saturé
• A23L 33/175 - Acides aminés
• A61P 35/00 - Agents anticancéreux
• C07C 211/21 - Monoamines
• C07C 233/05 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec des atomes de carbone de groupes carboxamide liés à des atomes de carbone d'un squelette carboné saturé acyclique ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques

Abrégé

Provided is a novel compound which is contained in a watermelon young fruit and has an antioxidative effect.　A novel compound which is contained in a watermelon young fruit and is represented by formula (1) or (2) has an antioxidative effect, and also has an anti-skin-aging effect. The compound is an extract from a plant that has been traditionally eaten, and is therefore very highly safe for human bodies. Therefore, an antioxidative pharmaceutical composition, an antioxidative processed food composition and an anti-skin-aging composition each containing the compound as an active ingredient have high utility value as highly safe compositions.

Classes IPC  ?

• A61P 39/06 - Antiradicaux libres ou antioxydants
• C07H 15/203 - Carbocycles monocycliques autres que des cycles cyclohexaneSystèmes carbocycliques bicycliques
• A61K 31/7034 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine

Abrégé

The phytol contained in watermelon sprouts is known to have a cancer cell growth inhibiting effect. The problem, however, is the amount ingested to inhibit cancer cell growth is large.　A cancer cell growth inhibiting composition having as the main ingredient at least one among compounds having structures represented by formula (1), formula (2), formula (6), formula (7), or formula (8) or pharmaceutically acceptable salts thereof has a higher cancer cell growth inhibiting effect than phytol.

Classes IPC  ?

• A61K 31/131 - Amines, p. ex. amantadine acycliques
• A61K 31/16 - Amides, p. ex. acides hydroxamiques
• A61P 35/00 - Agents anticancéreux
• C07C 211/21 - Monoamines
• C07C 233/05 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec des atomes de carbone de groupes carboxamide liés à des atomes de carbone d'un squelette carboné saturé acyclique ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques
• C07C 233/09 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec des atomes de carbone de groupes carboxamide liés à des atomes de carbone d'un squelette carboné acyclique non saturé
• A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs

Abrégé

A so-called molecular-targeted drug acting on a signal transduction pathway in a cell has been developed. However, a side effect of the molecular-targeted drug is not negligible for a patient. Thus, there has been a demand for a substance that exhibits a significant growth inhibitory effect on a cancer cell with fewer side effects as a health food and a pharmaceutical composition. It has been found that a hexane extract fraction of a watermelon sprout has an effect of specifically inhibiting the cell growth of the cancer cell and such an effect is primarily caused by phytol and lutein. A processed food and pharmaceutical composition having these substances as main components can exert an anticancer action without causing side effects.

Classes IPC  ?

• A61K 36/42 - Cucurbitaceae (famille du concombre)
• A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
• A61P 35/00 - Agents anticancéreux

Abrégé

Drugs called molecularly targeted agents are being developed which act on signal transmission pathways in cells. However, the side effects cannot be said to be a low burden on patients. Accordingly, there is still demand for substances which exhibit a significant cancer cell growth-inhibiting effect, and few side effects, as health foods and pharmaceutical compositions. The hexane extraction fraction of watermelon sprouts has an effect of specifically inhibiting cancer cell growth. The main causes of this effect are understood to be phytol and lutein. Accordingly, a processed food and a pharmaceutical composition which have these as main ingredients can provide anticancer action with no side effects.

Classes IPC  ?

• A61K 31/045 - Composés hydroxylés, p. ex. alcoolsLeurs sels, p. ex. alcoolates
• A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
• A61K 31/047 - Composés hydroxylés, p. ex. alcoolsLeurs sels, p. ex. alcoolates ayant plusieurs groupes hydroxyle, p. ex. sorbitol
• A61K 36/42 - Cucurbitaceae (famille du concombre)
• A61P 35/00 - Agents anticancéreux