According to an aspect of the present invention, there is provided an apparatus for ultrasonic welding of a removal thread (1) of an intrauterine system (2). The apparatus comprises a welding jig (3) comprising a welding groove (4), the welding groove having a length Lg, a width Wg and a depth Dg and a bottom (5) with concave shape. The apparatus further comprises a sonotrode (6) having a length Ls that is 150-220% of Lg, a width Ws of a welding tip (7) of the sonotrode that is 80-98% of Wg and a depth Ds. Further, the welding tip of the sonotrode has a concave shape.
The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).
The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material.
The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material.
A further object of the invention is to fabricate drug-containing T-intrauterine systems (IUS) with the drug incorporated within the entire backbone of the medical device by using 3D printing technique, based on fused deposition modelling (FDM™). Indomethacin was used to prepare drug-loaded poly-caprolactone (PCL)-based filaments with different drug contents 5-40 wt %, namely 5%, 15% and 30% wt %:of Indomethacin.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
B33Y 80/00 - Produits obtenus par fabrication additive
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
A61K 31/567 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en position 17 alpha, p. ex. mestranol, noréthandrolone
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
4.
AN INSERTER FOR AN INTRAUTERINE SYSTEM WITH A LOCKING PART
Disclosed is an inserter (1100, 1300, 1400, 1500) for an intrauterine system (1102, 1336, 1402, 1502), comprising a handle body (1104, 1306, 1416, 1504), a measurement tube (1110, 1328, 1406, 1510), a plunger (1132, 1202, 1362, 1450, 1532), a flange (1122, 1404, 1522), a finger holder (1124, 1314, 1446, 1524), and a means (1126, 1526) for reversibly locking removal thread (1128, 1358, 1414) of the intrauterine system. A proximal end (1106, 1440, 1506) of the measurement tube is movably attached to a distal end (1108, 1330, 1454, 1508) of the handle body, and the measurement tube is arranged to remain outside a cervix channel during insertion. The plunger is movably arranged inside the handle body and the measurement tube. The present disclosure also provides a kit comprising the inserter and the intrauterine system.
Disclosed is an intrauterine system (100, 300, 400, 500, 600) comprising a frame (102, 302, 402, 502, 602), a removal thread (218, 326, 436, 626) and at least one pharmaceutically active agent. The frame has a first end (104, 304, 404, 504, 604), a second end (106, 306, 406, 506, 606) and a length L. The first end of the frame comprises a first locking part (108, 308, 408, 508, 608) and the second end of the frame comprises a second locking part (110, 310, 410, 510, 610), the first locking part and the second locking part being arranged to form a lock (202, 312, 432). The removal thread is attached to the first end of the frame. The removal thread is configured to guide the first locking part to the second locking part. Further, disclosed is a kit comprising the aforementioned intrauterine system and an inserter.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Contraceptive pharmaceutical preparations contained in and released from a sub dermal implant An unfilled contraceptive implant to be inserted under the skin for releasing hormones
According to an aspect of the present invention, there is provided an apparatus for ultrasonic welding of a removal thread (1) of an intrauterine system (2). The apparatus comprises a welding jig (3) comprising a welding groove (4), the welding groove having a length Lg, a width Wg and a depth Dg and a bottom (5) with concave shape. The apparatus 5 further comprises a sonotrode (6) having a length Ls that is 150-220 % of Lg, a width Ws of a welding tip (7) of the sonotrode that is 80-98 % of Wg and a depth Ds. Further, the welding tip of the sonotrode has a concave shape.
The invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a moveable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunder (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunder (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).
b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunger (2) having a first end and a second end, with its second end attached to the slider (5). The inserter further includes a lock that reversibly locks the intrauterine system in relation to the plunger (2) via a removal string of the intrauterine system, the lock being controllable by the slider (5) and/or the insertion tube (6).
b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunger (2) having a first end and a second end, with its second end attached to the slider (5). The inserter further includes a lock that reversibly locks locking the intrauterine system in relation to the plunger (2) via a removal string of the intrauterine system, the lock being controllable by the slider (5) and/or the insertion tube (6).
The present invention relates to ultrasonically detectable intrauterine systems and to a method for enhancing ultra-sound detection of these systems. An intrauterine sys-tem having an inert metal coating on at least part of the body of the intrauterine system or at least one inert metal clip, pin, ring or sleeve fixedly positioned on the body of the intrauterine system is described.
The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence.
The invention furthermore relates to a drug delivery device with reduced initial burst containing two different drugs in different segments.
The invention further relates to a delivery device manufactured according to the a.m. method and its use in contraception and gynecological therapies.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/565 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol
A61K 31/567 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en position 17 alpha, p. ex. mestranol, noréthandrolone
An inserter for an intrauterine system can include a handle having an opening, a slider arranged in the opening, a plunger attached to the handle, an insertion tube attached to the slider and arranged around the plunger, and a lock adapted to reversibly lock at least one removal string of the intrauterine system. The lock can include a main part with an opening, the main part being rotatably mounted on a shaft or axle, an extension of the main part, and a counterpart. The removal string passes through the opening of the main part and is immobilized between the main part and the counterpart when the lock is in a locking position. The slider is configured to press against the extension of the main part and turn the main part around the shaft or axle to release the removal string as the slider is moved backwards.
The present invention relates to a method for marking a removal thread (4, 8, 12, 14, 16) of an intrauterine system (3), the removal thread having a length L, the method comprising using laser marking. The invention also relates to use of laser marking for marking a removal thread of an intrauterine system, as well as to the intrauterine system itself.
Disclosed is an intrauterine system (100, 300, 400, 500, 600) comprising a frame (102, 302, 402, 502, 602), a removal thread (218, 326, 436, 626) and at least one pharmaceutically active agent. The frame has a first end (104, 304, 404, 504, 604), a second end (106, 306, 406, 506, 606) and a length L. The first end of the frame comprises a first locking part (108, 308, 408, 508, 608) and the second end of the frame comprises a second locking part (110, 310, 410, 510, 610), the first locking part and the second locking part being arranged to form a lock (202, 312, 432). The removal thread is attached to the first end of the frame. The removal thread is configured to guide the first locking part to the second locking part. Further, disclosed is a kit comprising the aforementioned intrauterine system and an inserter.
Disclosed is an inserter (1100, 1300, 1400, 1500) for an intrauterine system (1102, 1336, 1402, 1502), comprising a handle body (1104, 1306, 1416, 1504), a measurement tube (1110, 1328, 1406, 1510), a plunger (1132, 1202, 1362, 1450, 1532), a flange (1122, 1404, 1522), a finger holder (1124, 1314, 1446, 1524), and a means (1126, 1526) for reversibly locking removal thread (1128, 1358, 1414) of the intrauterine system. A proximal end (1106, 1440, 1506) of the measurement tube is movably attached to a distal end (1108, 1330, 1454, 1508) of the handle body, and the measurement tube is arranged to remain outside a cervix channel during insertion. The plunger is movably arranged inside the handle body and the measurement tube. The present disclosure also provides a kit comprising the inserter and the intrauterine system.
Disclosed is an intrauterine system (100, 500, 700, 800, 900) comprising a frame (102, 502, 702, 802, 902, 1020), at least one sleeve (104, 508, 602, 704, 706, 804, 806, 808, 1016) and at least one capsule (106, 504, 506, 708, 710, 810, 812, 814, 904, 906, 1018). The frame has a first 5 end (108, 512, 714, 818, 914) and a second end (110, 516, 718, 822, 918). The sleeve having a first end (522, 604, 724, 728, 830, 834, 1022) and a second end (122, 524, 606, 726, 730, 832, 1024) is arranged to movably surround a part (1028) of the frame. The capsule comprises a pharmaceutically active agent. The capsule having a first end (126, 924, 10 928) and a second end (128, 926, 930) is arranged to surround the sleeve. Furthermore, disclosed is a kit comprising the aforementioned intrauterine system and an inserter.
Disclosed is an inserter (1100, 1400, 1500) for an intrauterine system (1402, 1522), comprising a handle (1102, 1418, 1502), an inner tube (1122, 1300, 1438, 1506), a measurement tube (1110, 1406, 1504), a plunger (1128, 1448, 1540), a flange (1118, 1404, 1530), a tip cover (1116, 1422, 1520), and means (1120, 1420, 1514) for moving the plunger. A proximal end (1112, 1516) of the measurement tube is movably connected to a distal end (1106, 1426, 1510) of the handle. The measurement tube is movably arranged to surround the inner tube. The plunger is movably arranged inside the inner tube and has a proximal end (1130, 1538) and a distal end (1132), and its distal end is configured to cooperate with the intrauterine system. The present disclosure also provides a kit comprising the inserter and the intrauterine system.
The present invention relates to an inserter for an intrauterine system, comprising a handle (1,11), an insertion tube (4) having a longitudinal direction and connected to the handle, and a plunger (3) arranged inside the insertion tube. The inserter also comprises a force sensor (6, 5 9) arranged between the insertion tube and the handle. The insertion tube is partially arranged inside the force sensor in such a manner that when force is exerted on the insertion tube along its longitudinal direction, the insertion tube is arranged to move with respect to the force sensor.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical publications in the nature of brochures, magazines and booklets in the field of gynecology Conducting scientific studies in the field of gynecology Medical services in the field of gynecology
Disclosed is a sound applicator (100, 1000, 1100, 1200, 1300, 1400) comprising a handle (102, 1002, 1102, 1202, 1302, 1402) and a sound tube (116, 602, 1004, 1104, 1204, 1304, 1404). The handle has a proximal end (104, 1210) and a distal end (106, 1212), and comprises a container (108, 1020, 1312, 1406) for an anaesthetic product (814) and a means (110, 1018, 1106, 1206) for discharging the anaesthetic product from the container. The sound tube has a proximal end (118) and a distal end (120), having length L. The proximal end of the sound tube is attachable to the distal end of the handle for allowing the anaesthetic product to enter the sound tube. The sound tube comprises openings (122) arranged along a distance D from its distal end. The present disclosure also provides a kit for a sound applicator.
the filler is selected from silica, titanium dioxide, barium sulphate, carbon and mixtures thereof; the elastomer comprised in the core and the elastomer comprised in the coating solution are independently selected from poly(dimethyl) siloxanes, polyethylene vinyl acetates (EVAs), polyurethanes (PUs), polyhydroxyethyl methacrylates (PHEMAs) and polymethyl methacrylates (PMMAs).
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61K 31/5415 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame condensés en ortho ou en péri avec des systèmes carbocycliques, p. ex. phénothiazine, chlorpromazine, piroxicam
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2). The invention is characterised in that it further comprises a flange (4) arranged on the insertion tube (6) at its first end, and means for locking the slider (5) into a position showing the correct insertion depth for the intrauterine system, said means being adjustable with respect to the opening (8) of the handle.
The present invention relates to a tenaculum comprising a suction head (1) and a handle part (3) connected to each other by a suction tube (2), the handle part comprising a vacuum pump. The vacuum pump comprises a vacuum tank (12) comprising a first opening at its first end and a second opening at its second end, wherein the suction tube is connected to the first opening; a spring (16); means for compressing the spring (4); and a piston. The piston comprises a piston head (13) moveably arranged within the vacuum tank; an axle (15) having a first end and a second end, its first end being connected to the piston head (13) and its second end being connected to the means for compressing the spring (4); and a pressure seal (14) arranged on the piston head to isolate a vacuum space of the vacuum tank from the second opening. The spring (16) is arranged to move the piston head (13).
A61B 17/42 - Instruments ou procédés de gynécologie ou d'obstétrique
A61M 1/00 - Dispositifs de succion ou de pompage à usage médicalDispositifs pour retirer, traiter ou transporter les liquides du corpsSystèmes de drainage
The present invention relates to a method for modifying release of a therapeutically active agent from an elastomeric matrix, comprising providing a core comprising an elastomeric matrix and a therapeutically active agent; dipping the core to a coating solution of an elastomer, wherein the elastomer comprises 20-35 wt-% of a filler, calculated from the total amount of filler and elastomer; curing the dipped core to provide a coated core. In this method the dipping is provided as a continuous process by pulling the core through the coating solution, using a pulling speed suitable for providing a coating thickness of δ-ΙΟΟμιΐη; the filler is selected from silica, titanium dioxide, barium sulphate, carbon and mixtures thereof; the elastomer comprised in the core and the elastomer comprised in the coating solution are independently selected from poly(dimethyl) siloxanes, polyethylene vinyl acetates (EVAs), polyurethanes (PUs), polyhydroxyethyl methacrylates (PHEMAs) and polymethyl methacrylates (PMMAs).
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
A61K 31/5415 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame condensés en ortho ou en péri avec des systèmes carbocycliques, p. ex. phénothiazine, chlorpromazine, piroxicam
The present invention relates to an inserter for an intrauterine system, comprising a handle (1,11), an insertion tube (4) having a longitudinal direction and connected to the handle, and a plunger (3) arranged inside the insertion tube. The inserter also comprises a force sensor (6, 5 9) arranged between the insertion tube and the handle. The insertion tube is partially arranged inside the force sensor in such a manner that when force is exerted on the insertion tube along its longitudinal direction, the insertion tube is arranged to move with respect to the force sensor.
The invention relates to a method for producing a drug delivery device, which has a body comprising a siloxane-based elastomer and at least one active agent. The method comprises applying adhesive material, which comprises non-cured siloxane based elastomer, into a contact with the body and curing the said adhesive material by subjecting it to radiation energy from a laser source. The invention relates also to a drug delivery device manufactured according to the method.
A61K 31/567 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en position 17 alpha, p. ex. mestranol, noréthandrolone
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
37.
INTRAVAGINAL DRUG DELIVERY SYSTEM, METHOD FOR MANUFACTURING SUCH SYSTEM AND ITS USE IN GYNECOLOGICAL THERAPIES AND CONTRACEPTION
The invention relates to an intravaginal ring consisting of an inert carrier material (A) embedding at least on drug containing insert, wherein the insert(s) are made of a biocompatible polymer material (B) which is enclosed with a cylinder wall (sleeve) made of an inert material impermeable to the drag to reduce the amount of unused drag substance at the end of the wearing period and thus reducing the environmental burden when the IVR is disposed.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/195 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61K 31/565 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol
A61K 31/567 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en position 17 alpha, p. ex. mestranol, noréthandrolone
A61K 31/57 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 31/569 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en positions 10 et 13 par une chaîne ayant au moins un atome de carbone, p. ex. androstane, testostérone substitués en position 17 alpha, p. ex. œthistérone
The present invention relates to an inserter for an eye implant, comprising a hollow cover (31) having a first end and a second end and at least one cover slot (35) along its longitudinal direction; a slider (37) movably arranged inside the cover, having a first end and a second end; sliding means (36) movably arranged in the cover slot and attached to the slider, for moving the slider; a needle (32) having a first end and a second end, attached to the slider; and a plunger (34) arranged inside the cover and partially inside the slider at the second end of the slider, and partially inside the needle; wherein the plunger is arranged to move together with the slider when the slider is moved in a first direction, and the plunger is arranged to remain stationary when the slider is moved in a second direction opposite the first direction.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
The present invention relates to an inserter for an eye implant, comprising a hollow cover (31) having a first end and a second end; a slider (35) movably arranged inside the cover, having a first end and a second end; sliding means (36) movably arranged on the cover and attached to the slider, for moving the slider; a needle (32) having a first end and a second end, arranged to move within the slider; and a plunger (38) arranged inside the slider, partially inside the needle and attached to the cover; wherein the slider is arranged to move in relation to the plunger.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
The present invention relates to an inserter for an eye implant, comprising a hollow cover (31) having a first end (31a) and a second end (31b) and at least one cover slot (35) along its longitudinal direction; a slider (37) movably arranged inside the cover, having a first end (37a) and a second end (37b); sliding means (36) movably arranged in the cover slot and releasably attached to the slider; a needle (32) having a first end (32a) and a second end, arranged to move within the slider; a plunger (34) arranged inside the slider, partially inside the needle and attached to the cover; and a first elastic element (40) arranged inside the cover to move the slider when the sliding means is released from the slider; wherein the slider is arranged to move in relation to the plunger.
A61F 9/00 - Procédés ou dispositifs pour le traitement des yeuxDispositifs pour mettre en place des verres de contactDispositifs pour corriger le strabismeAppareils pour guider les aveuglesDispositifs protecteurs pour les yeux, portés sur le corps ou dans la main
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
43.
Long acting drug delivery device and its use in contraception
The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence. The invention furthermore relates to a drug delivery device with reduced initial burst containing two different drugs in different segments. The invention further relates to a delivery device manufactured according to the a.m. method and its use in contraception and gynecological therapies.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/565 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol
A61K 31/567 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en position 17 alpha, p. ex. mestranol, noréthandrolone
Disclosed are an inserter and an inserter kit for an intrauterine system. The inserter comprises an insertion tube having a first end and an opposite second end, wherein the first end is operable to removably receive the intrauterine system and a handle having a first end portion and an opposite second end portion, the first end portion of the handle is coupled to the second end of the insertion tube. The handle comprises a handling mechanism for controlling movement of the insertion tube with respect to the intrauterine system. The inserter also comprises an indicating mechanism operatively arranged in connection with the insertion tube and the handle, the indicating mechanism is communicably coupled to the handling mechanism and is operable to provide indicative signals corresponding to operational stages of the inserter. The indicative signals comprise at least one light signal and the indicating mechanism comprises a power source.
A61F 6/14 - Dispositifs de contraceptionPessairesDispositifs pour les introduire à usage féminin du type intra-utérin
A61F 6/18 - Dispositifs pour les introduire ou les enlever
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
An intelligent medical implant and monitoring system includes an implant with a communication device, an inserter for inserting the implant, a reader that operates to broadcast a signal specific to the particular communication device that causes the communication device to respond with a unique identifier, and an external database for storing and providing access to information keyed to the unique identifier of the communication device.
A61F 6/20 - Obturateurs du canal déférentObturateurs des trompes de Fallope
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61B 1/05 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments combinés avec des dispositifs photographiques ou de télévision caractérisés par le fait que le capteur d'images, p. ex. l'appareil photographique, est placé dans la partie de l'extrémité distale
A61B 1/06 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments avec dispositifs d'éclairement
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
A61B 90/98 - Moyens d’identification pour les patients ou les instruments, p. ex. étiquettes utilisant des moyens électromagnétiques, p. ex. transpondeurs
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61F 2/82 - Dispositifs maintenant le passage ou évitant l’affaissement de structures tubulaires du corps, p. ex. stents
G06F 17/30 - Recherche documentaire; Structures de bases de données à cet effet
H04L 29/08 - Procédure de commande de la transmission, p.ex. procédure de commande du niveau de la liaison
46.
AN ARRANGEMENT FOR AN INTRAUTERINE SYSTEM AND ITS INSERTER
The present invention relates to an arrangement comprising an intrauterine system, an inserter for the intrauterine system and a package for the inserter, wherein the inserter comprises a handle having a first end and a second end, an insertion tube having a first end and a second end, first handling means for withdrawing the intrauterine system inside the insertion tube and second handling means for expulsing the intrauterine system from the insertion tube; and the package comprises a container, a cover arranged to close the container and means for actioning the first handling means of the inserter.
b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2). The invention is characterised in that it further comprises a flange (4) arranged on the insertion tube (6) at its first end, and means for locking the slider (5) into a position showing the correct insertion depth for the intrauterine system, said means being adjustable with respect to the opening (8) of the handle.
The present invention relates to a novel thermoplastic polyurethane (TPU) elastomer, T-frames made thereof as well as the use of the new TPU in manufacturing of T-frames for intrauterine systems for contraception and therapy.
C08G 18/73 - Polyisocyanates ou polyisothiocyanates acycliques
C08G 18/22 - Catalyseurs contenant des composés métalliques
C08G 18/24 - Catalyseurs contenant des composés métalliques de l'étain
C08G 18/28 - Polymérisats d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs caractérisés par l'emploi de composés spécifiés contenant un hydrogène actif
b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunger (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunger (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).
The present invention relates to a method of manufacturing a vaginal ring, wherein the vaginal ring comprises at least one therapeutically active agent and a body comprising a crosslinked siloxane elastomer. The method comprises manufacturing the body in the form of a rod having a first end and a second end and forming the body into a ring by arranging an attachment part between the first end of the body and the second end of the body, wherein the attachment part comprises a non-crosslinked siloxane elastomer having a weight average molecular weight of 650-850 g/mol and a cross-linking catalyst, and curing the attachment part for a period of time of 1-30 second using a temperature of 125-220°.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
53.
METHOD FOR MANUFACTURING A DRUG DELIVERY DEVICE AND A DRUG DELIVERY DEVICE MANUFACTURED ACCORDING TO THE METHOD
The invention relates to a method for producing a drug delivery device, which has a body comprising a siloxane-based elastomer and at least one active agent. The method comprises applying adhesive material, which comprises non-cured siloxane based elastomer, into a contact with the body and curing the said adhesive material by subjecting it to radiation energy from a laser source. The invention relates also to a drug delivery device manufactured according to the method.
The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence. The invention furthermore relates to a drug delivery device with reduced initial burst containing two different drugs in different segments. The invention further relates to a delivery device manufactured according to the a.m. method and its use in contraception and gynecological therapies.
A61K 31/565 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol
A61K 31/567 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes non substitués en position 17 bêta par un atome de carbone, p. ex. œstrane, œstradiol substitués en position 17 alpha, p. ex. mestranol, noréthandrolone
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical Publications in the field of gynecology such as brochures, magazines and booklets. Conducting scientific studies in the field of gynecology. Medical services in the field of gynecology.
The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material. A further object of the invention is to fabricate drug-containing T-intrauterine systems (I US) with the drug incorporated within the entire backbone of the medical device by using 3D printing technique, based on fused deposition modelling (FDM™). Indomethacin was used to prepare drug-loaded poly-caprolactone (PCL)-based filaments with different drug contents 5—40 wt%, namely 5%, 15% and 30% wt%:of Indomethacin.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
B29C 67/00 - Techniques de façonnage non couvertes par les groupes , ou
67.
NOVEL THERMOPLASTIC POLYURETHANES, USE OF THESE MATERIAL FOR THE PREPARATION OF T-FRAMES FOR INTRAUTERINE SYSTEMS AND T-FRAMES MADE OUT OF THIS MATERIAL
The present invention relates to a novel thermoplastic polyurethane (TPU) elastomer, T-frames made thereof as well as the use of the new TPU in manufacturing of T-frames for intrauterine systems for contraception and therapy.
C08G 18/22 - Catalyseurs contenant des composés métalliques
C08G 18/24 - Catalyseurs contenant des composés métalliques de l'étain
C08G 18/28 - Polymérisats d'isocyanates ou d'isothiocyanates avec des composés contenant des hydrogènes actifs caractérisés par l'emploi de composés spécifiés contenant un hydrogène actif
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61F 6/14 - Dispositifs de contraceptionPessairesDispositifs pour les introduire à usage féminin du type intra-utérin
C08K 3/30 - Composés contenant du soufre, du sélénium ou du tellure
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical preparations, namely hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical preparations, namely, hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical preparations, namely, hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical preparations, namely, hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical preparations, namely, hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical preparations, namely, hormonal preparations for contraceptive use
(2) Medical devices, namely, intrauterine devices for contraceptive use
b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2). The invention is characterized in that it further comprises a flange (4) arranged on the insertion tube (6) at its first end, and means for locking the slider (5) into a position showing the correct insertion depth for the intrauterine system, said means being adjustable with respect to the opening (8) of the handle.
A61F 6/18 - Dispositifs pour les introduire ou les enlever
A61F 6/14 - Dispositifs de contraceptionPessairesDispositifs pour les introduire à usage féminin du type intra-utérin
90.
INTRAVAGINAL USE OF 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, INTRAVAGINAL RINGS COMPRISING 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, AND USE THEREOF IN CONTRACEPTION
The present invention relates to intravaginal use of 18-methyl-15ß,16ß-methylene-19-nor-20-spirox-4-en-3-ones of the general formula (I), to an intravaginal ring comprising 18-methyl-15ß,16ß-methylene-19-nor-20-spirox-4-en-3-ones of the general formula (I) and its use in contraception.
The present invention relates to an improved method of contraception which addresses the problems of initial bleeding and spotting associated with the use of intrauterine delivery systems, and to an improved intrauterine delivery system.
A61K 31/57 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
The invention relates to a training inserter (1) for an intrauterine system, said intrauterine system comprising a body (11) and removal strings (17), the training inserter comprising a handle (2) having a first end (3) and a second end (4), an insertion tube (5) having a first end (6) and a second end (7), and being arranged in connection with the handle (2), for receiving the intrauterine system, a plunger arranged inside the insertion tube (5), and first means for moving the insertion tube (5) with respect to the plunger for pushing out the intrauterine system. The training inserter further comprises second means (14, 18) that perform the following functions: attaching the removal strings to the inserter, pulling back the intrauterine system via the removal strings, and storing the removal strings.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
16 - Papier, carton et produits en ces matières
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceuticals, namely, hormonal preparations Medical device, namely, an intrauterine device for contraception Printed matter, namely, brochures and information cards, all in the field of women's health, birth control and reproductive options Providing a website featuring general and educational information in the field of women's health, birth control and reproductive options; providing general and educational information in the field of women's health, birth control and reproductive options
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
16 - Papier, carton et produits en ces matières
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceuticals, namely, hormonal preparations comprised in whole or significant part of levonorgestrel Medical device, namely, an intrauterine device for contraception Printed matter, namely, brochures and information cards, all in the field of women's health, birth control and reproductive options Providing a website featuring general and educational information in the field of women's health, birth control and reproductive options; providing general and educational information in the field of women's health, birth control and reproductive options
