A fluid injector system includes at least one fluid reservoir having a first fluid reservoir configured for injecting a radiopharmaceutical and a radiation filter in fluid communication with the at least one fluid reservoir. The radiation filter is configured for retaining radioactive particles from the radiopharmaceutical passing though the radiation filter. The system further includes at least one sensor configured to detect radioactivity in at least one of the first fluid reservoir, the radiation filter, and a fluid path element in fluid communication with the radiation filter; and a controller in operative communication with the at least one sensor. The controller is programmed or configured to receive a radioactivity measurement from the at least one sensor and determine, based on the radioactivity measurement, that an amount of radioactive particles in at least one of the first fluid reservoir, the radiation filter, and the fluid path set satisfies a predetermined threshold.
A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/165 - Accessoires de filtrage, p. ex. filtres pour le sang, pour les liquides de perfusion
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
3.
SYSTEM, METHOD AND DEVICE FOR DELIVERY OF A THERAPEUTIC OR DIAGNOSTIC AGENT
A fluid injector system includes at least one fluid reservoir having a first fluid reservoir configured for injecting a radiopharmaceutical and a radiation filter in fluid communication with the at least one fluid reservoir. The radiation filter is configured for retaining radioactive particles from the radiopharmaceutical passing though the radiation filter. The system further includes at least one sensor configured to detect radioactivity in at least one of the first fluid reservoir, the radiation filter, and a fluid path element in fluid communication with the radiation filter; and a controller in operative communication with the at least one sensor. The controller is programmed or configured to receive a radioactivity measurement from the at least one sensor and determine, based on the radioactivity measurement, that an amount of radioactive particles in at least one of the first fluid reservoir, the radiation filter, and the fluid path set satisfies a predetermined threshold.
A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/165 - Accessoires de filtrage, p. ex. filtres pour le sang, pour les liquides de perfusion
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
4.
NOVEL RNA-PROGRAMMABLE ENDONUCLEASE SYSTEMS AND USES THEREOF
Aspects of this invention, inter alia, relate to novel systems for targeting, editing or manipulating DNA in a cell, using novel synthetic RNA-guided nucleases (sRGNs). The sRGNs are derived from wildtype or parental small type II CRISPR Cas9 endonucleases.
Provided is a disinfecting cap for a fluid path element having an inner lumen and an outer cylindrical wall surrounding the inner lumen. The disinfecting cap includes a housing configured to receive the inner lumen and the outer cylindrical wall of the fluid path element. The housing has an open proximal end, a closed distal end, and a sidewall extending between the open proximal end and the closed distal end to define an interior volume. A sleeve protrudes proximally from an inner surface of the closed distal end and defines an opening configured to receive the inner lumen of the fluid path element. A compressible absorbent material at least partially saturated with a disinfecting fluid is disposed within the interior volume of the housing and surrounding at least a portion of the sleeve.
A61M 39/16 - Raccords ou accouplements pour tubes avec des dispositions pour la désinfection ou la stérilisation
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
Disclosed herein are system, method, and computer program product embodiments for associating injector and imager protocols. For example, the method may include: receiving, from an imaging system including an imager configured to image a patient, imager protocol data associated with an imager protocol according to which the imaging system is configured to control imaging of the patient with the imager, the imaging system being in communication with an injection system including an injector configured to deliver fluid and/or imaging agent to the patient; receiving, via at least one user interface, at least one of a selection, a programming, a modification, or any combination thereof of an injector protocol according to which the injection system is configured to control delivery of at least one fluid and/or imaging agent to the patient with the injector; and associating, in at least one database, the imager protocol with the injector protocol.
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
7.
EFFERVESCENT COMPOSITION AND METHOD FOR DETERMINING BITTERNESS PERCEPTION
An effervescent composition is provided herein that includes an effervescent combination including sodium bicarbonate and citric acid to taste mask the bitter taste perception of various molecules or compositions, such as an active pharmaceutical ingredient or a composition including an active pharmaceutical ingredient. Also provided is a method of reducing bitterness perception of a molecule or composition by adding the effervescent combination; and a method of determining bitterness perception of a molecule or a composition by measuring electric potential and optionally adjusting the bitterness perception of the molecule or composition by adding the effervescent combination.
A system, method, and computer program product for implementing a remote console for use in diagnostic imaging may include a user interface and/or at least one processor programmed and/or configured to: receive, from at least one of an injection system including an injector configured to deliver fluid to a patient and an imaging system including a scanner configured to scan the patient, procedure data associated with a procedure for the patient, at least one of the injection system and the imaging system including at least one further user interface different than the user interface, and the injection system being in communication with the imaging system; provide, via the user interface, a display, the display being generated based on the procedure data; receive, via the user interface, user input; and control, based on the user input, an operation of at least one of the injection system and the imaging system.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
9.
EFFERVESCENT COMPOSITION AND METHOD FOR DETERMINING BITTERNESS PERCEPTION
An effervescent composition is provided herein that includes an effervescent combination including sodium bicarbonate and citric acid to taste mask the bitter taste perception of various molecules or compositions, such as an active pharmaceutical ingredient or a composition including an active pharmaceutical ingredient. Also provided is a method of reducing bitterness perception of a molecule or composition by adding the effervescent combination; and a method of determining bitterness perception of a molecule or a composition by measuring electric potential and optionally adjusting the bitterness perception of the molecule or composition by adding the effervescent combination.
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 31/485 - Dérivés du morphinane, p. ex. morphine, codéine
The present invention relates to safe pharmaceutical formulations to stabilize a therapeutic anti-CCR8 antibody. The pharmaceutical formulation is provided as a liquid, such as a frozen liquid, or in a lyophilized from, and may be in a ready-to-use form or may be further diluted for intravenous or subcutaneous administration.
A fluid path connector assembly for a medical fluid delivery system includes a connector element having a body, a lumen extending through the body, and a pair of flexible legs connected to the body, each of the flexible legs having a flange. The connector assembly further includes a dust cap removably connected to the connector element. The dust cap includes a dust cap body positioned between the flexible legs to enclose the lumen, and an engagement element at a distal end of the dust cap body. The engagement element is in contact with the flanges of the flexible legs to prevent disengagement of the dust cap from the connector element while allowing ready removal of the dust cap by medical personnel. A removable/disconnectable tamper resistant and/or tamper-evident and/or tamper resistant feature connecting the dust cap to the connector element is also disclosed.
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/50 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour empêcher la réutilisation ou pour indiquer si le dispositif est défectueux, usagé, non stérile ou si l'on a tenté de l'utiliser
12.
SYSTEM, METHOD AND COMPUTER PROGRAM FOR GUIDED WORKFLOW FEATURES FOR OPERATING A FLUID INJECTOR SYSTEM
Methods for providing one or more guided workflow features with regard to a fluid injector system, may include receiving data associated with the fluid injector system, displaying a first graphical user interface (GUI) screen associated with a guided workflow for operation of the fluid injector system on one or more display devices based on the data associated with one or more components of the fluid injector system, receiving a first user input, displaying a second GUI screen associated with the guided workflow on the one or more display devices based on receiving the first user input, executing a first operation of the fluid injector system, and receiving a second user input, where the second GUI screen provides information that is sequential to the first GUI screen with regard to the guided workflow for operation of the fluid injector system. Systems and computer program products are also disclosed.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
G16H 70/20 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des pratiques ou des directives
The present invention relates to liquid chemical formulations that are useful as domestic laundry additives for deactivating and/or denaturing one or more allergens and/or killing dust mites on textiles. The present invention also relates to processes for preparing such formulations and methods for the use of the formulations to deactivate and/or denature one or more allergens and/or kill dust mites on textiles.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Analgesics; Antihistamines; Cough treatment preparations; Cough suppressants; Decongestants; Pain relief medication; Preparation for the relief of pain; Antipyretics; Preparations for treating colds and flu
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Analgesics; Antihistamines; Antipyretics; Cough treatment preparations; Cough suppressants; Decongestants; Pain relief medication; Preparation for the relief of pain; Preparations for treating colds and flu
Provided are child-proof stick packs comprising: a single sheet of film comprising two or more layers, wherein at least one layer comprises polyethylene terephthalate and faces an environment exterior to the stick pack; a laser-scored design on the film comprising a plurality of scores, wherein each score of the plurality of scores comprises an area in which the polyethylene terephthalate layer is weakened or removed from the film, wherein the stick pack comprises a bottom seal, a top seal, and a rear seal extending between the top seal and the bottom seal, is configured to contain one or more of an active pharmaceutical ingredient, therapeutic agent, or supplement and cannot be opened by more than 20% of children under the age of 5 years using only two hands.
Provided is a system for managing automated healthcare data applications using artificial intelligence (AI) that includes at least one processor programmed or configured to receive healthcare data from a data source, determine a classification of the healthcare data using a machine learning model, wherein the machine learning model is configured to provide a predicted classification of an automated healthcare data analysis application of a plurality of automated healthcare data analysis applications based on an input, and provide the healthcare data to an automated healthcare data analysis application based on the classification of the healthcare data. Methods and computer program products are also disclosed.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 15/00 - TIC spécialement adaptées aux rapports médicaux, p. ex. leur création ou leur transmission
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
Devices, kits, and methods for heating a drug formulation in an injection device are disclosed. An embodiment of the device includes a housing enclosure having a first housing shell and a second housing shell, and a plurality of bladders adjacent to an inner surface of the first housing shell and adjacent to an inner surface of the second housing shell. The housing enclosure is designed to receive the injection device. When an edge of the first housing shell and an edge of the second housing shell couple, the bladders contact a portion of the injection device and heat the drug formulation in the injection device. An embodiment of the kit includes this device and the injection device.
A61M 5/44 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour refroidir ou pour chauffer les dispositifs ou les agents
A syringe for delivery of liquid to a container has a body with proximal end, a frustoconical distal end, and a cylindrical sidewall extending a longitudinal axis. The syringe includes a nozzle at a distal portion of the syringe, the nozzle having a throughbore providing fluid communication between an interior volume of the syringe and a medical connector configured to be connected to the nozzle. The nozzle includes a plurality of longitudinal ribs formed on an inner surface of the nozzle. The plurality of longitudinal ribs directs a flow of a medical fluid along an inner surface of the frustoconical distal end and along an interior surface of the cylindrical sidewall of the syringe under a Coandă effect. Syringe and methods for reducing a number of bubbles formed in a medical fluid during a syringe filling procedure are described.
Implementations relate to a container fitment that includes a rotatable restrictor. In some implementations, a fitment for a container includes a plug and a collar. The plug is coupled to an aperture of the container and includes one or more plug dispensing apertures and a plug air aperture. The collar is rotatably coupled to the plug and includes one or more collar dispensing apertures and a collar air aperture. A spring is positioned between the plug and the collar. The collar is rotatable to a restricted orientation and an unrestricted orientation. In the restricted orientation, the collar dispensing apertures are unaligned with the plug dispensing apertures to prevent product in the container from dispensing through the dispensing apertures. In the unrestricted orientation, the collar and plug dispensing apertures are aligned to allow the product to dispense. The spring provides a spring force that biases the collar toward the restricted orientation.
B65D 47/26 - Fermetures avec dispositifs de décharge autres que des pompes comportant des éléments fonctionnant à la main pour commander l'évacuation avec soupapes coulissantes, p. ex. sous forme de becs d'évacuation coulissants
B65D 47/32 - Fermetures avec dispositifs de décharge autres que des pompes comportant des évents
Systems and methods for distribution, storage, transport, administration and/or disposal of one or more therapeutic or diagnostic agents are disclosed. A storage device configured to connect to a delivery system for delivering the therapeutic or diagnostic agent has a housing with a chamber, a vessel having an access port positioned within the chamber. The door is movable relative to the housing between a closed position and an open position. In the closed position, the door covers an opening in the housing to enclose the chamber, and, in the open position, the door reveals the opening for accessing the access port of the vessel. The door is moveable between the closed position and the open position in response to actuation by an access mechanism of the delivery system.
A61J 1/05 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques pour recueillir, stocker ou administrer du sang, du plasma ou des liquides à usage médical
A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques DétailsAccessoires à cet effet
G21F 5/04 - Moyens pour commander l'exposition, p. ex. la durée, la dimension de l'ouverture
An administration line for use with a fluid injector system includes a fluid verification module configured to be in operative communication with a housing of the fluid injector system such that the fluid injector system can determine a status of the administration line. The fluid verification module includes a body defining an inlet port, an outlet port, and a fluid channel extending from the inlet port to the outlet port; a first tubing section connected to the inlet port; and a second tubing section connected to the outlet port.
A61M 5/50 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour empêcher la réutilisation ou pour indiquer si le dispositif est défectueux, usagé, non stérile ou si l'on a tenté de l'utiliser
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
25.
System, Method and Device for Delivery of a Therapeutic or Diagnostic Agent
A fluid injector system includes at least one fluid reservoir having a first fluid reservoir configured for injecting a radiopharmaceutical and a radiation filter in fluid communication with the at least one fluid reservoir. The radiation filter is configured for retaining radioactive particles from the radiopharmaceutical passing though the radiation filter. The system further includes at least one sensor configured to detect radioactivity in at least one of the first fluid reservoir, the radiation filter, and a fluid path element in fluid communication with the radiation filter; and a controller in operative communication with the at least one sensor. The controller is programmed or configured to receive a radioactivity measurement from the at least one sensor and determine, based on the radioactivity measurement, that an amount of radioactive particles in at least one of the first fluid reservoir, the radiation filter, and the fluid path set satisfies a predetermined threshold.
A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/165 - Accessoires de filtrage, p. ex. filtres pour le sang, pour les liquides de perfusion
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
26.
SYSTEM AND METHOD FOR DETECTING FLUID TYPE IN TUBING FOR FLUID INJECTOR APPARATUS
A fluid injector system includes at least one injector for pressurizing and delivering at least one fluid from at least one fluid reservoir, at least one fluid path section providing fluid communication between a bulk fluid reservoir and a syringe, and at least one sensor arranged along the at least one fluid path section. The sensor includes an emitter configured to emit light through the at least one fluid path section, and a detector configured to receive the light emitted from the emitter and generate a signal based on a property of the received light. The fluid injector system further includes at least one processor programmed or configured to determine, based on the electrical signal, an identity of the fluid present in the fluid path section, a concentration of the fluid in the fluid path section, and/or a property of the fluid path section.
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/36 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour éliminer l'air ou pour empêcher l'injection ou l'introduction d'air dans le corps
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for treating allergies; Antihistamines; Decongestants; Nasal spray preparations; Medicated moisturizers; Nasal sprays for medical purposes; Saline solution for sinus and nasal irrigation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for treating allergies; Antihistamines; Decongestants; Nasal spray preparations; Medicated moisturizers; Nasal sprays for medical purposes; Saline solution for sinus and nasal irrigation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for treating allergies; Antihistamines; Decongestants; Nasal spray preparations; Medicated moisturizers; Nasal sprays for medical purposes; Saline solution for sinus and nasal irrigation
A fluid injector system includes a multi-use disposable set (MUDS) connectable to a powered fluid injector. The MUDS includes a syringe having a proximal end and a distal end and a reciprocally movable plunger; a manifold in fluid communication with the distal end of the syringe; a rotatable valve in fluid communication with the syringe interior, the at least rotatable valve operable between a filling position for filling the syringe with fluid and a delivery position for delivering the fluid from the syringe; and at least one connection port in fluid communication with the manifold and the syringe interior when the at least one valve is in the delivery position. The injector system further includes a coupling mechanism for operating the at least one valve between the filling position and the delivery position.
A61J 3/00 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/19 - Seringues avec plusieurs compartiments
An injector system for delivering a medical fluid may include at least one syringe defining a reservoir operatively connected to a piston; and at least one processor programmed or configured to, based on an air check protocol for detecting air in the reservoir, determine a baseline value comprising baseline compressibility data for the at least one syringe of the injector system, deliver the first amount of the medical fluid from the reservoir; refill the reservoir with a second amount of the medical fluid; based on the air check protocol, perform an air check pressurization sequence by gathering air check compressibility data for the at least one syringe of the injector system; and based on the air check protocol, compare the air check compressibility data with the baseline compressibility data to determine a volume of air present in the reservoir.
A61M 5/36 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour éliminer l'air ou pour empêcher l'injection ou l'introduction d'air dans le corps
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A system for sensing at least one pressure jacket on a fluid injector includes at least one first magnetic component connected to a proximal end of the at least one pressure jacket, at least one second magnetic component associated with a front end of the fluid injector and configured to magnetically interact with the first magnetic component on the proximal end of the at least one pressure jacket, and at least one sensor associated with the front end of the fluid injector and configured for detecting at least one property of a magnetic field. A change in the at least one property of the magnetic field detected by the at least one sensor is configured to indicate a presence or an absence of the at least one pressure jacket.
A balancing system for a fluid injector system may include abase arm; the fluid injector system rotatably mounted to the base arm at a pivot point; and a gas spring disposed at least partially within the base arm and mounted to the fluid injector system. The fluid injector system has a weight that may create an injector moment about the pivot point, and the gas spring may be configured to apply a spring force to the fluid injector system, and the spring force may create a spring moment about the pivot point. The spring moment may act in a direction opposing the injector moment to at least partially offset the injector moment.
A fluid injector system and computer program product on a control device of the fluid injector system is described. The control device has at least one processor programmed or configured to actuate a second drive component to pressurize and inject the second fluid through the fluid conduit, and while the second drive component is actuated, actuate a first drive component to introduce intermittent pulses of the first fluid to create a flow front interface between the first fluid and the second fluid in the fluid conduit to prevent backflow of the second fluid through the fluid conduit into the first fluid reservoir.
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
A medical connector for providing a sterile connection between a multi-use portion and a single-use portion of a fluid delivery system is provided. The medical connector includes a fluid inlet port configured for removable engagement with a connection port of a multi-use disposable set (MUDS) to establish a fluid connection therewith and a waste outlet port configured for removable engagement with a waste inlet port of the MUDS to establish a fluid connection therewith. A patient fluid line is connected, at a first end, to the fluid inlet port and connected, at a second end, to the waste outlet port. Fluid flow through the patient fluid line is unidirectional from the first end to the second end. The patient fluid line is configured for being disconnected from the waste outlet port for delivering fluid to a patient. A multi-fluid delivery system having the medical connector and MUDS is also provided.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
42.
SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR PREDICTIVE MAINTENANCE
A method, system, and computer program product for predictive maintenance. A method may include receiving operation data associated with one or more injection systems, wherein the operation data includes one or more operation parameters associated with one or more operations of the one or more injection systems; determining one or more prediction scores for the one or more injection systems based on the operation data, wherein the one or more prediction scores include one or more predictions of one or more operation failures or misuses for the one or more injection systems; and providing maintenance data associated with the one or more operation failures or misuses, wherein the maintenance data is based on the one or more prediction scores.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p. ex. pour planifier la maintenance ou les mises à jour
G06Q 10/20 - Administration de la réparation ou de la maintenance des produits
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
43.
COMPOSITIONS AND METHODS FOR GENE EDITING BY TARGETING TRANSFERRIN
Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., Hemophilia A, employing ex vivo and/or in vivo genome editing.
The present application provides materials and methods for treating a patient with one or more of Usher Syndrome Type 2A and ARRP, both ex vivo and in vivo; materials and methods for editing an USH2A gene containing a guanine deletion at nucleotide position c.2299. In addition, the present application provides one or more gRNAs or sgRNAs for editing an USH2A gene containing a guanine deletion at nucleotide position c.2299; a therapeutic comprising at least one or more gRNAs or sgRNAs for editing an USH2A gene containing a guanine deletion at nucleotide position c.2299; and a therapeutic for treating a patient with one or more of Usher Syndrome Type 2A and ARRP. The present application also provides a kit for treating a patient with one or more of Usher Syndrome Type 2A and ARRP.
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
Systems for providing machine learning analytics of healthcare information may include at least one processor to: receive healthcare data associated with a patient from a plurality of data sources including at least one of an electronic medical record system, a patient procedure tracking system, a hospital information system, a radiology information system, a radiology analytics system, a laboratory information system, a digital pathology system, a picture archive and communication system, or any combination thereof; determine a medical finding for the patient using a machine learning model based on the healthcare data associated with the patient, wherein the medical finding includes at least one of a proposed diagnosis for the patient or a recommendation to perform one or more tests on the patient: and provide data associated with the medical finding for the patient to a device associated with the patient for display. Methods and computer program products are also disclosed.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
The present application provides materials and methods for controlling gene editing. The present application also provides materials and methods for controlling transcriptional expression of guide RNAs and/or post-transcriptional expression of Cas nuclease.
C12N 15/64 - Méthodes générales pour la préparation du vecteur, pour son introduction dans la cellule ou pour la sélection de l'hôte contenant le vecteur
The present embodiments relate to alternate potency targeting manufacturing. Subject matter of the present embodiments provides computer-implemented methods, computer systems and computer-readable storage media for predicting the results of alternate potency targeting manufacturing methods.
G06Q 10/0639 - Analyse des performances des employésAnalyse des performances des opérations d’une entreprise ou d’une organisation
G16C 20/30 - Prévision des propriétés des composés, des compositions ou des mélanges chimiques
G16H 70/40 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des médicaments, p. ex. leurs effets secondaires ou leur usage prévu
50.
MULTI-USE AND SINGLE-USE DEVICES FOR INJECTOR INTERFACES
A connection system may include an interface having a housing and a sensor disposed within the housing and configured to be displaced between a first position, a second position, and a third position; a multi-use fitting having at least one engaging surface and a slot and being configured to be secured within the housing so that the at least one engaging surface displaces the sensor between the first position and the second position; and a single-use fitting having a flange and being configured to be secured within the multi-use fitting such that the flange is received within and extends through the slot and displaces the sensor between the second position and the third position. The sensor may be configured to detect displacement between the first, second, and third positions, thereby sensing engagement between the multi-use fitting and the interface and engagement between the single-use fitting and the multi-use fitting.
A fluid injector system for use in administering to a patient a fluid in an injection protocol in connection with a diagnostic imaging procedure includes at least one display and a control device. The control device is programmed to determine, for each of the injection protocols performed by the fluid injector system, a component status for the at least one disposable component. The component status indicates whether use of the at least one disposable component was compliant with instructions for use applicable to the at least one disposable component. The control device is further programmed to enable the at least one display to display a compliance report. The compliance report includes one or more visual indicators providing visual feedback about compliance with the instructions for use based on the component status determined for each of the injection protocols performed using the fluid injector system.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
52.
AMMONIUM SULFATE TREATED SYRINGE FOR INCREASED PHARMACEUTICAL COMPOSITION STABILITY
Ammonium sulfate treated prefilled syringes, and kits that include an ammonium sulfate treated prefilled syringe and a pharmaceutical composition comprising an aluminum-sensitive active agent, are described herein. Treating the inner surface of a glass syringe barrel with ammonium sulfate prior to filling the syringe with a desired aqueous diluent, such as water for injection, can limit the amount of aluminum that leach into the aqueous diluent during storage.
An exemplary method for assessing performance of an instance of a chemical process having a series of consecutive phases includes: obtaining data related to the instance of the chemical process; and evaluating, based on the data related to the instance of the chemical process, the performance of the instance of the chemical process using a plurality of performance thresholds, wherein the plurality of performance thresholds is obtained by training a hierarchical model based on one or more historical instances of the chemical process, and wherein the hierarchical model includes: a plurality of batch-evolution models (BEMs) at a first level of a hierarchy; a plurality of batch-level models (BLMs) at a second level above the first level of the hierarchy; and an overall performance model at a third level at a third level above the second level of the hierarchy.
G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
54.
NOBLE GAS DELIVERY DEVICE, CARTRIDGE, AND TRIGGERING SYSTEM FOR LUNG FUNCTIONAL AND STRUCTURAL IMAGING
Delivery devices, cartridges, and triggering systems are provided for lung functional and structural imaging using a noble gas. An example cartridge (10) configured for connection to a delivery device (112) for delivery of an inhalation contrast agent to a patient (124) via inhalation for lung functional and structural imaging may include a reservoir (12) containing at least one dose of the inhalation contrast agent for delivery to the patient and a closure (14) sealing the at least one dose of the inhalation contrast agent in the reservoir. The closure may be configured to open when the cartridge is inserted into the delivery device. A delivery device for delivery of the noble gas contrast agent contained in a cartridge to a patient via inhalation for lung functional and structural imaging, a lung functional and structural imaging system, and method for imaging a lung of a patient are also provided.
A fluid delivery system and method for determining whether the correct fluid is being drawn into and/or dispensed from a syringe. The system includes a syringe, a fluid injector for drawing fluid into and dispensing fluid from the syringe, one or more sensors adapted to measure a force required to draw the fluid into and/or dispense the fluid from the syringe, a processor in communication with the one or more sensors, and a non-transitory, computer-readable storage medium in operable communication with the processor. The computer-readable storage medium contains one or more programming instructions that, when executed, cause the processor to receive from the one or more sensors one or more measurements of the force required to draw the fluid into and/or dispense the fluid from the syringe and determine from the one or more measurements whether a correct fluid is being drawn into and/or dispensed from the syringe.
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
56.
SYSTEM AND METHOD FOR SYRINGE PLUNGER ENGAGEMENT WITH AN INJECTOR
A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engageable with the piston regardless of a rotational orientation of the piston relative to the plunger.
Systems for providing a medical procedure plan may include a fluid injector and at least one processor to select a specific dosage amount of a contrast agent from a plurality of dosage amounts of the contrast agent that is to be administered by a fluid injection system during an injection procedure for a patient; automatically execute an injection protocol for the injection procedure based on selecting the specific dosage amount of the contrast agent from the plurality of dosage amounts of contrast agent where the injection protocol includes the specific dosage amount; generate an image of an area of a body of the patient based on automatically executing the injection protocol; generate an image analysis result of the image of the area of the body of the patient; and determine whether the image analysis result satisfies a threshold of image quality. Methods, fluid injectors, and components thereof are also disclosed.
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
58.
EXTENDED, HIGH DOSE VEGF ANTAGONIST REGIMENS FOR TREATMENT OF ANGIOGENIC EYE DISORDERS
The present invention relates to regimens for the treatment of angiogenic eye disorders such as nAMD, DR and DME characterized by high doses of aflibercept extended periods between doses.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C07K 14/71 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des facteurs de croissanceRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des régulateurs de croissance
59.
GENE EDITING FOR HEMOPHILIA A WITH IMPROVED FACTOR VIII EXPRESSION
Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
60.
SYSTEM AND METHOD FOR FLUID DELIVERY USING PRESSURE-BASED MOTOR CONTROL FOR FLUID INJECTOR DEVICES
A system, method, and computer program product are disclosed for a flow rate algorithm that utilizes changes in fluid pressure over a set time interval to calculate a true flow rate compared to a programmed flow rate, determine any over-delivery or under-delivery in the amount of fluid delivered over the set time interval, compensate for any determined over-delivery or under-delivery in the fluid flow rate over a subsequent set time interval, and repeat the flow rate algorithm for a series of subsequent set time intervals over the duration of a fluid injection procedure.
A fluid mixing device for mixing a first injection fluid and a second injection fluid includes a first fluid inlet, a second fluid inlet, a mixing chamber in fluid communication with the first and second fluid inlets, and an outlet port in fluid communication with the mixing chamber. The first fluid inlet is configured to conduct the first injection fluid in a first direction and has a first redirecting surface. The second fluid inlet is configured to conduct the second injection fluid in a second direction along a different axis from the first direction and has a second redirecting surface. The mixing chamber is configured to mix the first injection fluid and the second fluid together. The mixture of the first injection fluid and the second injection fluid exits the fluid mixing device via the outlet port.
A prime tube for use with a fluid injector includes a patient tube connector and a connection interface for removably connecting a distal end of the patient tube connector to a proximal end of the prime cap. The connection interface includes a first connector at the proximal end of the prime cap, and a second connector at the distal end of the patient tube connector. The prime cap is removably engageable with a prime tube housing having a sensing arrangement for sensing the presence of the prime cap and for sensing whether the prime cap is filled with air or filled with a liquid for monitoring the progress of a priming operation.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/50 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour empêcher la réutilisation ou pour indiquer si le dispositif est défectueux, usagé, non stérile ou si l'on a tenté de l'utiliser
63.
SYSTEM AND METHOD FOR SYRINGE PLUNGER ENGAGEMENT WITH AN INJECTOR
A plunger for use with a syringe includes a plunger body defining a central longitudinal axis and having a proximal end, a distal end, and a circumferential sidewall connecting the proximal end and the distal end. The plunger further includes at least one retaining member associated with and extending proximally from the plunger body. The at least one retaining member has a first end connected to the plunger body, a second end proximal to the first end and radially and resiliently deflectable relative to the first end, and at least one catch on the second end. A fluid injector system includes a piston having a plunger engagement mechanism configured for interacting with the at least one retaining element of the plunger to releasably engage the plunger for reciprocally driving the plunger within a barrel of the syringe.
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
A61M 5/36 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour éliminer l'air ou pour empêcher l'injection ou l'introduction d'air dans le corps
Provided is a system for generation of artificial intelligence (Al) based automated healthcare applications that includes an Al medical device platform that comprises at least one processor in communication with a data repository system, the at least one processor configured to receive formatted data associated with a plurality of medical procedures for generation of one or more machine learning models, receive data associated with one or more regulatory guidance and approval processes, generate one or more machine learning models configured to predict one or more aspects associated with a medical procedure based on the data associated with the plurality of medical procedures and the data associated with the regulatory guidance and approval process, and deploy the one or more machine learning models to a production environment based on generating the one or more machine learning models. Methods and computer program products are also disclosed.
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
A syringe including a proximal end, a distal end, and a cylindrical sidewall extending between the proximal end and the distal end, wherein the distal end comprises a conical distal end wall and a fluid nozzle at a distal end of the conical distal end wall; a cylindrical load bearing wall extending axially from the cylindrical sidewall past a proximal end of the conical distal end wall; and a plurality of radial ribs positioned around a periphery of the conical distal end wall, wherein a longitudinal axis of the plurality of radial ribs extends radially inward from the cylindrical load bearing wall towards the fluid nozzle over at least a portion of the conical distal end wall.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
85.
PACKAGING, STORAGE, AND PROTECTIVE TECHNIQUES FOR MEDICAL SYRINGES AND FLUID PATH COMPONENTS
A syringe packaging system and associated methods are described. The syringe packaging system may include a dividing wall arrangement defining a plurality of spaces; and a container configured to receive the dividing wall arrangement and a plurality of syringes therein. At least a portion of the plurality of spaces may be configured to receive individual syringes of the plurality of syringes therein. The syringes are received in an upright, substantially parallel configuration and the dividing wall arrangement divides each individual syringe from one or more adjacent syringes. The syringe packaging system allows for reduced medical waste, improved recyclability, and a minimized carbon footprint. Methods for sterilizing a plurality of syringes contained in a packaging system is disclosed.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
B65D 43/16 - Couvercles ou chapeaux inamovibles s'ouvrant à charnières vers le haut ou vers le bas
B01L 9/00 - Dispositifs de supportDispositifs de serrage
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
86.
SYSTEM AND METHOD FOR SYRINGE FLUID FILL VERIFICATION AND IMAGE RECOGNITION OF POWER INJECTOR SYSTEM FEATURES
A fluid injection system and a fluid verification system for determining the operating status of the fluid injection system, for example by confirming that a fluid reservoir, containing a fluid for injection, is fully filled with fluid and has free space (i.e., air) near the distal end thereof when the syringe is provided in an upright position nor contains air bubbles. Imaging processing techniques, methods, and systems are also provided to determine various injection parameters and to verify the type and certain properties of fluid that is present within the fluid reservoir.
A61M 5/36 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour éliminer l'air ou pour empêcher l'injection ou l'introduction d'air dans le corps
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
A61M 5/44 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour refroidir ou pour chauffer les dispositifs ou les agents
G01F 23/02 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p. ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme par tubes de niveau ou autres appareils impliquant une fenêtre ou un tube transparent pour observer directement le niveau à mesurer ou celui d'une colonne de liquide de communication libre avec la cuve principale du liquide
87.
FLUID INJECTOR SYSTEM WITH DUAL DISPLAY ARRANGEMENT
A fluid injector system having a dual display arrangement is described. The fluid injector system includes a primary display device located inside a sterile field in an angiography suite and an overlay display device positioned in proximity to a fluid injector of the fluid injector system and located outside of the sterile field. The primary display device includes a primary user interface that provides certain control functionality for a fluid injector and is operable by a user within the sterile field, and the overlay display device is associated with the primary display device and includes an overlay user interface that provides control functionality for the fluid injector and is operable by a user outside of the sterile field.
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
88.
CASSETTE FOR RETENTION OF FLUID PATH COMPONENTS FOR FLUID INJECTOR SYSTEM
A cassette for holding fluid path components for a fluid injector may include a body defining at least one feature for holding at least one fluid path component for the fluid injector; and a connecting member for removably connecting the body of the cassette to the fluid injector, the connecting member operatively connected to the body, wherein the connecting member comprises at least one pivotable connecting feature protruding from the body, and wherein each of the at least one pivotable connecting feature is configured for removably connecting to a corresponding connecting feature receiver on the fluid injector such that the body is pivotally movable relative to the fluid injector between a first, unlatched position and a second, latched position in which the at least one fluid path component on the body of the cassette is positioned for operative connection to a corresponding feature of the fluid injector.
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/36 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour éliminer l'air ou pour empêcher l'injection ou l'introduction d'air dans le corps
89.
SYSTEMS AND METHODS FOR USE IN DELIVERY OF FLUID USING TUBING TO HOLD CONTRAST MEDIA PRIOR TO SALINE FLUSH
A system for use in delivery of precise, small volumes of medical fluid to a patient is described. The system includes a first tubing set having a first length of tubing and a second length of tubing, a first connector member positioned at the proximal end of the first length of tubing configured to connect to a syringe, and a valve assembly positioned at the distal end of the first length of tubing. The system utilizes a section of the first length of tubing to measure and contain the small volumes of medical fluid for flushing into a patient through the valve assembly and second length of tubing.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
90.
CONVENIENT SINGLE DOSE MR CONTRAST AGENT PACKAGE AND ACCURATE DELIVERY SYSTEM
A fluid injector system configured to perform an injection procedure in connection with a diagnostic imaging procedure includes an administration line having a cartridge defining an internal chamber. The cartridge includes an inlet port in fluid communication with the internal chamber, an outlet port in fluid communication with the internal chamber, a medical fluid contained within the internal chamber, and a plunger movable within the internal chamber. The administration line further includes an inlet tube in fluid communication with the inlet port and configured for connection to a fluid injector and an outlet tube in fluid communication with the outlet port. The fluid injector system may also include a controller configured to actuate the fluid injector.
Systems for operating a fluid injection system may include at least one processor to receive patient data associated with a patient undergoing a fluid injection procedure, automatically generate at least one parameter of an injection protocol for the fluid injection procedure based on the patient data and independent of an input associated with a dosage of a medical fluid for the fluid injection procedure received via a user interface associated with a fluid injection system that is to execute the fluid injection procedure, wherein, when automatically generating the at least one parameter, the at least one processor is to determine the dosage of the medical fluid for the fluid injection procedure, and provide the at least one parameter of the injection protocol to the fluid injection system. Methods and computer program products are also disclosed.
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
92.
ORALLY DISINTEGRATING TABLET AND METHODS OF MAKING THEREOF
Provided are orally-disintegrating tablets (ODTs) and methods of making ODTs that include introducing air into a liquid tableting composition to form a foam tableting composition, dosing the foam tableting composition to form a dosed tableting composition, and drying the dosed tableting composition to form the ODTs.
Systems for artificial intelligence based event management may include at least one processor to receive data associated with an event involving a medical device via a user interface (Ul) associated with the medical device; receive data associated with an identification characteristic of the medical device; generate an event message; wherein the event message comprises the data associated with the event involving the medical device and the data associated with the identification characteristic of the medical device; provide a response message via the Ul associated with the medical device based on the data associated with the event involving the medical device; where the response message includes information based on an output of a generative and conversational artificial intelligence (Al) platform; determine a category of the event message; and perform an action based on the category of the event message. Methods and computer program products are also disclosed.
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p. ex. pour planifier la maintenance ou les mises à jour
G06Q 30/016 - Fourniture d’une assistance aux clients, p. ex. pour assister un client dans un lieu commercial ou par un service d’assistance après-vente
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
H04L 51/02 - Messagerie d'utilisateur à utilisateur dans des réseaux à commutation de paquets, transmise selon des protocoles de stockage et de retransmission ou en temps réel, p. ex. courriel en utilisant des réactions automatiques ou la délégation par l’utilisateur, p. ex. des réponses automatiques ou des messages générés par un agent conversationnel
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
H04L 67/12 - Protocoles spécialement adaptés aux environnements propriétaires ou de mise en réseau pour un usage spécial, p. ex. les réseaux médicaux, les réseaux de capteurs, les réseaux dans les véhicules ou les réseaux de mesure à distance
94.
SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR AUTOMATED DIAGNOSTIC IMAGING PROCEDURES
Systems, methods, and computer program products are provided for automated diagnostic imaging procedures. An example system includes at least one processor configured to: communicate, with a fluid injection system including a fluid injector, an imaging system including an imager, a sensor system including at least one sensor, and a user device, procedure data associated with a patient and a patient procedure associated with the patient; determine, based on the procedure data, whether a threshold for performing a next portion of the patient procedure is satisfied; and enable, based on a determination that the threshold for performing the next portion of the patient procedure is satisfied, at least one of the fluid injection system including the fluid injector, the imaging system including the imager, the sensor system including the at least one sensor, and the user device, to perform the next portion of the patient procedure.
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/172 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte électriques ou électroniques
G16H 20/17 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients administrés par perfusion ou injection
95.
Fluid mixing device and fluid delivery tube set including same
A fluid mixing device for mixing a first injection fluid and a second injection fluid includes a first fluid inlet, a second fluid inlet, a mixing chamber in fluid communication with the first and second fluid inlets, and an outlet port in fluid communication with the mixing chamber. The first fluid inlet is configured to conduct the first injection fluid in a first direction and has a first redirecting surface. The second fluid inlet is configured to conduct the second injection fluid in a second direction along a different axis from the first direction and has a second redirecting surface. The mixing chamber is configured to mix the first injection fluid and the second fluid together. The mixture of the first injection fluid and the second injection fluid exits the fluid mixing device via the outlet port.
A plunger, a syringe, system, and a method for increasing a seal between a sidewall of a plunger and a sidewall of a syringe are disclosed. The plunger includes a support ring and a cover disposed over and coupled to the support ring. A cavity defining a predetermined volume is defined between the support ring and the cover. The syringe includes a barrel defining an inner wall and the plunger inserted therein.
What is described herein relates to a method for separating host cell proteins from proteins of interest, comprising the following steps
a) subjecting a mixture of host cell proteins and proteins of interest to at least a Protein A chromatography followed by a cation exchange chromatography (CEX) and up to two ion exchange chromatography (IEX) steps wherein one of the two ion exchange chromatography steps is a mixed mode chromatography (MM AEX/CEX) and the other one is an anion exchange membrane adsorber (MA AEX) in flow through mode OR
b) subjecting a mixture of host cell proteins and proteins of interest to non-ionic detergent during a Protein A chromatography wash step.
A fluid path connector for a medical fluid delivery system, the fluid path connector including a first connector element comprising a body, a first lumen, a first flexible leg, and a second flexible leg, and a second connector element comprising a body defining an undercut, a second lumen, a channel defined in the body, and at least one sealing element positioned within the channel, in which the first flexible leg comprises a first flange and the second flexible leg comprises a second flange, and in which, upon engagement of the first connector element with the second connector element, the first flange and the second flange engage with the undercut of the body of the second connector element to prevent disengagement of the first connector element and the second connector element.
Provided are liquid, solid, and semi-solid oral pharmaceutical compositions comprising a multi-component taste-masking physical barrier. The oral pharmaceutical compositions comprise an active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable excipients, a pH modifying agent, and the multi-component taste-masking physical barrier comprising one or more of an ion exchange resin, a cyclodextrin, and a hydrocolloid.
A powered fluid injector including an assembly for retaining a pressure jacket and a syringe on a fluid injector is provided. The assembly includes a base plate comprising a body; a first retaining arm and a second retaining arm operatively mounted on the body of the base plate, wherein the first retaining arm have a first retaining surface and the second retaining arm having a second retaining surface. The first retaining surface and the second retaining surface abut a distal surface of at least one of the pressure jacket and the syringe. The assembly also includes a linkage assembly connected to at least one of the first retaining arm and/or the second retaining arm to move the retaining arms between at least a first open position and a closed position.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
